KRT8P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)9.80998345
2desmosome organization (GO:0002934)8.85914176
3keratinization (GO:0031424)7.94348986
4establishment of skin barrier (GO:0061436)7.22349968
5keratinocyte differentiation (GO:0030216)7.18928337
6regulation of water loss via skin (GO:0033561)6.56948341
7peptide cross-linking (GO:0018149)6.50054948
8keratinocyte proliferation (GO:0043616)6.20716739
9ectoderm development (GO:0007398)6.09296220
10establishment of planar polarity (GO:0001736)5.92492492
11establishment of tissue polarity (GO:0007164)5.92492492
12epidermal cell differentiation (GO:0009913)5.88659179
13eyelid development in camera-type eye (GO:0061029)5.78878311
14keratinocyte development (GO:0003334)5.69819989
15hemidesmosome assembly (GO:0031581)5.38717498
16membrane protein ectodomain proteolysis (GO:0006509)5.13148410
17gap junction assembly (GO:0016264)4.97400257
18artery smooth muscle contraction (GO:0014824)4.83662945
19multicellular organismal water homeostasis (GO:0050891)4.61917573
20atrioventricular valve morphogenesis (GO:0003181)4.60157429
21negative regulation of keratinocyte proliferation (GO:0010839)4.55392642
22negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.52059719
23regulation of heart rate by cardiac conduction (GO:0086091)4.48832598
24positive regulation of p38MAPK cascade (GO:1900745)4.46587000
25regulation of keratinocyte proliferation (GO:0010837)4.43339349
26intestinal epithelial cell development (GO:0060576)4.40520654
27epidermis development (GO:0008544)4.28631681
28planar cell polarity pathway involved in neural tube closure (GO:0090179)4.22895646
29hair cycle (GO:0042633)4.16645246
30molting cycle (GO:0042303)4.16645246
31tonic smooth muscle contraction (GO:0014820)4.07519974
32lateral sprouting from an epithelium (GO:0060601)4.00460425
33interferon-gamma secretion (GO:0072643)3.97639620
34regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.92283490
35water homeostasis (GO:0030104)3.83165228
36branching involved in labyrinthine layer morphogenesis (GO:0060670)3.81761790
37regulation of keratinocyte differentiation (GO:0045616)3.79813297
38prostaglandin biosynthetic process (GO:0001516)3.79699772
39prostanoid biosynthetic process (GO:0046457)3.79699772
40positive regulation of epidermal cell differentiation (GO:0045606)3.74844199
41wound healing, spreading of epidermal cells (GO:0035313)3.69937374
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.69781723
43regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.66379553
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.60835541
45transepithelial transport (GO:0070633)3.57801818
46negative regulation of epidermis development (GO:0045683)3.57763382
47negative regulation of epidermal cell differentiation (GO:0045605)3.53923464
48ventricular cardiac muscle cell action potential (GO:0086005)3.48761487
49hepatocyte differentiation (GO:0070365)3.46563758
50inositol phosphate-mediated signaling (GO:0048016)3.46248991
51cardiac muscle cell action potential involved in contraction (GO:0086002)3.45722189
52energy homeostasis (GO:0097009)3.44803144
53cardiac conduction (GO:0061337)3.43464385
54cell adhesion mediated by integrin (GO:0033627)3.43144108
55cellular potassium ion homeostasis (GO:0030007)3.41189454
56response to lipoprotein particle (GO:0055094)3.41134504
57activation of Rac GTPase activity (GO:0032863)3.37596401
58cellular protein complex localization (GO:0034629)3.34345090
59response to UV-B (GO:0010224)3.32885455
60membrane repolarization during action potential (GO:0086011)3.28749942
61polarized epithelial cell differentiation (GO:0030859)3.26647252
62regulation of cardioblast differentiation (GO:0051890)3.25927470
63membrane protein proteolysis (GO:0033619)3.25745575
64cardiac muscle cell action potential (GO:0086001)3.24617961
65surfactant homeostasis (GO:0043129)3.21419778
66DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16388859
67regulation of somitogenesis (GO:0014807)3.16145660
68regulation of p38MAPK cascade (GO:1900744)3.09509619
69regulation of epidermal cell differentiation (GO:0045604)3.07775602
70positive regulation of Cdc42 GTPase activity (GO:0043089)3.04041684
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.00178062
72regulation of cholesterol homeostasis (GO:2000188)2.99654091
73morphogenesis of an epithelial fold (GO:0060571)2.99362397
74positive regulation of epidermis development (GO:0045684)2.99309022
75negative regulation of protein localization to cell surface (GO:2000009)2.97153135
76prostanoid metabolic process (GO:0006692)2.94742405
77prostaglandin metabolic process (GO:0006693)2.94742405
78daunorubicin metabolic process (GO:0044597)2.94657279
79polyketide metabolic process (GO:0030638)2.94657279
80doxorubicin metabolic process (GO:0044598)2.94657279
81membrane protein intracellular domain proteolysis (GO:0031293)2.94001157
82chemical homeostasis within a tissue (GO:0048875)2.93844159
83mammary gland epithelial cell proliferation (GO:0033598)2.91463464
84cardiac right ventricle morphogenesis (GO:0003215)2.90866442
85glandular epithelial cell differentiation (GO:0002067)2.88383082
86epithelial cell-cell adhesion (GO:0090136)2.86463211
87DNA damage response, signal transduction resulting in transcription (GO:0042772)2.85463228
88regulation of protein localization to cell surface (GO:2000008)2.85155386
89negative regulation of protein tyrosine kinase activity (GO:0061099)2.79549958
90regulation of skeletal muscle contraction (GO:0014819)2.78604621
91regulation of epidermis development (GO:0045682)2.77973787
92nuclear envelope reassembly (GO:0031468)2.77669130
93mitotic nuclear envelope reassembly (GO:0007084)2.77669130
94intermediate filament cytoskeleton organization (GO:0045104)2.76928911
95post-anal tail morphogenesis (GO:0036342)2.73704797
96positive regulation of keratinocyte differentiation (GO:0045618)2.73413688
97intermediate filament organization (GO:0045109)2.72230258
98prostate gland epithelium morphogenesis (GO:0060740)2.67923271
99intermediate filament-based process (GO:0045103)2.65460297
100morphogenesis of embryonic epithelium (GO:0016331)2.63861605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.77377875
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.80377585
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.16416765
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.79309319
5ESR1_21235772_ChIP-Seq_MCF-7_Human4.01286606
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.25702314
7HIF1A_21447827_ChIP-Seq_MCF-7_Human3.23227591
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.20986793
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.20986793
10E2F7_22180533_ChIP-Seq_HELA_Human3.06002472
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91526513
12AR_21909140_ChIP-Seq_LNCAP_Human2.67526320
13KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.51569547
14P63_26484246_Chip-Seq_KERATINOCYTES_Human2.50421261
15KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.49457809
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.30186870
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.18116137
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07748198
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.98584825
20ATF3_27146783_Chip-Seq_COLON_Human1.90106324
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88105648
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.87251844
23GATA6_25053715_ChIP-Seq_YYC3_Human1.85365129
24RUNX1_27514584_Chip-Seq_MCF-7_Human1.62570745
25FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62477349
26GATA4_25053715_ChIP-Seq_YYC3_Human1.61056083
27SOX2_20726797_ChIP-Seq_SW620_Human1.59215482
28RACK7_27058665_Chip-Seq_MCF-7_Human1.57496987
29ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.56495912
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53693590
31EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.53069145
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48497704
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48278625
34KLF5_25053715_ChIP-Seq_YYC3_Human1.48263042
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47650567
36CLOCK_20551151_ChIP-Seq_293T_Human1.46828819
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45159701
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.42409529
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41531019
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40964155
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39960358
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35575776
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34080601
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.32029050
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31956471
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.31622468
47CJUN_26792858_Chip-Seq_BT549_Human1.30521046
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28450040
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23339442
50AHR_22903824_ChIP-Seq_MCF-7_Human1.22646775
51TP63_23658742_ChIP-Seq_EP156T_Human1.20733207
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18279905
53CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14065092
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10911694
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08651599
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06727600
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06726365
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04165982
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02934062
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.02787516
61ZNF263_19887448_ChIP-Seq_K562_Human1.01723476
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00206593
63FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97652212
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96914007
65GATA6_21074721_ChIP-Seq_CACO-2_Human0.94288574
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93427718
67ELF5_23300383_ChIP-Seq_T47D_Human0.93147790
68KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93005921
69RXR_22108803_ChIP-Seq_LS180_Human0.92101093
70TP63_22573176_ChIP-Seq_HFKS_Human0.91631507
71PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90862211
72HNFA_21074721_ChIP-Seq_CACO-2_Human0.87424138
73UBF1/2_26484160_Chip-Seq_HMECs_Human0.85975690
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85542707
75E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82272073
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82173167
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79864666
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78829032
79FOXM1_23109430_ChIP-Seq_U2OS_Human0.78816008
80MYC_18555785_ChIP-Seq_MESCs_Mouse0.77634733
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77587650
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77152426
83DCP1A_22483619_ChIP-Seq_HELA_Human0.76973582
84RBPJ_21746931_ChIP-Seq_IB4_Human0.76697786
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.75892468
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75770913
87PHF8_20622853_ChIP-Seq_HELA_Human0.74942731
88NFYB_21822215_ChIP-Seq_K562_Human0.73086389
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.72390755
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70104952
91CHD1_26751641_Chip-Seq_LNCaP_Human0.67988091
92TP53_18474530_ChIP-ChIP_U2OS_Human0.66477535
93ETV1_20927104_ChIP-Seq_GIST48_Human0.66106988
94HTT_18923047_ChIP-ChIP_STHdh_Human0.65944441
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65510162
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65280338
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.65179232
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65047594
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.64409040
100ELK3_25401928_ChIP-Seq_HUVEC_Human0.64369842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.94481592
2MP0010234_abnormal_vibrissa_follicle6.02857175
3MP0003453_abnormal_keratinocyte_physiol4.10065031
4MP0005501_abnormal_skin_physiology4.01931163
5MP0000579_abnormal_nail_morphology3.98432985
6MP0005377_hearing/vestibular/ear_phenot3.62946512
7MP0003878_abnormal_ear_physiology3.62946512
8MP0010678_abnormal_skin_adnexa3.49916924
9MP0004264_abnormal_extraembryonic_tissu3.24986733
10MP0000383_abnormal_hair_follicle3.21298106
11MP0003941_abnormal_skin_development3.04208306
12MP0001216_abnormal_epidermal_layer2.97715060
13MP0003693_abnormal_embryo_hatching2.75054143
14MP0002060_abnormal_skin_morphology2.64244223
15MP0010771_integument_phenotype2.46888551
16MP0009053_abnormal_anal_canal2.37698471
17MP0000566_synostosis2.37596646
18MP0003315_abnormal_perineum_morphology2.36744814
19MP0002098_abnormal_vibrissa_morphology2.28679621
20MP0000467_abnormal_esophagus_morphology2.22793937
21MP0004885_abnormal_endolymph2.14368198
22MP0003566_abnormal_cell_adhesion2.13902238
23MP0003950_abnormal_plasma_membrane2.05472824
24MP0004043_abnormal_pH_regulation2.02991326
25MP0004185_abnormal_adipocyte_glucose1.90858943
26MP0000465_gastrointestinal_hemorrhage1.88745073
27MP0000537_abnormal_urethra_morphology1.88730444
28MP0003191_abnormal_cellular_cholesterol1.84894285
29MP0010352_gastrointestinal_tract_polyps1.83296550
30MP0004782_abnormal_surfactant_physiolog1.69279470
31MP0005670_abnormal_white_adipose1.68285930
32MP0005409_darkened_coat_color1.67334565
33MP0001849_ear_inflammation1.62977974
34MP0002877_abnormal_melanocyte_morpholog1.59872346
35MP0000377_abnormal_hair_follicle1.56347781
36MP0009780_abnormal_chondrocyte_physiolo1.53097771
37MP0005275_abnormal_skin_tensile1.52681958
38MP0004957_abnormal_blastocyst_morpholog1.43941979
39MP0003806_abnormal_nucleotide_metabolis1.40115435
40MP0000762_abnormal_tongue_morphology1.35114258
41MP0000427_abnormal_hair_cycle1.23047379
42MP0010030_abnormal_orbit_morphology1.15522106
43MP0001666_abnormal_nutrient_absorption1.15088913
44MP0001485_abnormal_pinna_reflex1.15026185
45MP0009840_abnormal_foam_cell1.12073047
46MP0009931_abnormal_skin_appearance1.10885031
47MP0004272_abnormal_basement_membrane1.07351497
48MP0002111_abnormal_tail_morphology1.06404340
49MP0008260_abnormal_autophagy1.06052815
50MP0002009_preneoplasia1.03973757
51MP0000627_abnormal_mammary_gland0.96105188
52MP0004381_abnormal_hair_follicle0.90153560
53MP0003705_abnormal_hypodermis_morpholog0.87440492
54MP0005076_abnormal_cell_differentiation0.84418479
55MP0005666_abnormal_adipose_tissue0.83853895
56MP0000647_abnormal_sebaceous_gland0.83478643
57MP0005023_abnormal_wound_healing0.83181543
58MP0005451_abnormal_body_composition0.82151752
59MP0001340_abnormal_eyelid_morphology0.79928557
60MP0002282_abnormal_trachea_morphology0.79195964
61MP0001851_eye_inflammation0.78557898
62MP0000367_abnormal_coat/_hair0.78532564
63MP0001191_abnormal_skin_condition0.76952900
64MP0000470_abnormal_stomach_morphology0.76529157
65MP0004019_abnormal_vitamin_homeostasis0.74565341
66MP0000477_abnormal_intestine_morphology0.71889046
67MP0005360_urolithiasis0.67911084
68MP0004947_skin_inflammation0.67857559
69MP0004197_abnormal_fetal_growth/weight/0.66282820
70MP0000858_altered_metastatic_potential0.62763908
71MP0001697_abnormal_embryo_size0.62528017
72MP0000516_abnormal_urinary_system0.60965408
73MP0005367_renal/urinary_system_phenotyp0.60965408
74MP0002086_abnormal_extraembryonic_tissu0.60703124
75MP0000613_abnormal_salivary_gland0.57200129
76MP0000013_abnormal_adipose_tissue0.57015381
77MP0001765_abnormal_ion_homeostasis0.55728865
78MP0003937_abnormal_limbs/digits/tail_de0.54482182
79MP0001730_embryonic_growth_arrest0.52438146
80MP0005197_abnormal_uvea_morphology0.51496707
81MP0000678_abnormal_parathyroid_gland0.50176699
82MP0003119_abnormal_digestive_system0.49754686
83MP0002006_tumorigenesis0.49069951
84MP0010094_abnormal_chromosome_stability0.48456697
85MP0001784_abnormal_fluid_regulation0.48428382
86MP0003718_maternal_effect0.46005634
87MP0001672_abnormal_embryogenesis/_devel0.45176106
88MP0005380_embryogenesis_phenotype0.45176106
89MP0000350_abnormal_cell_proliferation0.45067141
90MP0002084_abnormal_developmental_patter0.44484092
91MP0003936_abnormal_reproductive_system0.41513402
92MP0005083_abnormal_biliary_tract0.40558444
93MP0005365_abnormal_bile_salt0.39630561
94MP0002088_abnormal_embryonic_growth/wei0.38191053
95MP0003984_embryonic_growth_retardation0.38094785
96MP0000490_abnormal_crypts_of0.37871225
97MP0001661_extended_life_span0.37662361
98MP0003755_abnormal_palate_morphology0.37441851
99MP0002080_prenatal_lethality0.36009587
100MP0001243_abnormal_dermal_layer0.35550224

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.05398160
2Lip pit (HP:0100267)6.30068652
3Abnormality of secondary sexual hair (HP:0009888)6.14322661
4Abnormality of the axillary hair (HP:0100134)6.14322661
5Oral leukoplakia (HP:0002745)5.94309675
6Onycholysis (HP:0001806)5.82970310
7Alopecia of scalp (HP:0002293)5.55544300
8Congenital ichthyosiform erythroderma (HP:0007431)5.54916313
9Right ventricular cardiomyopathy (HP:0011663)5.53198583
10Erythroderma (HP:0001019)5.27258679
11Corneal erosion (HP:0200020)5.19870572
12Abnormality of the salivary glands (HP:0010286)5.12878427
13Palmoplantar hyperkeratosis (HP:0000972)4.90466175
14Plantar hyperkeratosis (HP:0007556)4.80012520
15Hypotrichosis (HP:0001006)4.76009787
16Palmar hyperkeratosis (HP:0010765)4.68488838
17Thick nail (HP:0001805)4.57571248
18Nail dystrophy (HP:0008404)4.55714166
19Sparse eyelashes (HP:0000653)4.19229983
20Amniotic constriction ring (HP:0009775)4.18922582
21Abnormality of placental membranes (HP:0011409)4.18922582
22Absent eyelashes (HP:0000561)4.06259634
23Ectropion (HP:0000656)3.94117786
24Hypohidrosis (HP:0000966)3.61383780
25Absent hair (HP:0002298)3.58625807
26Woolly hair (HP:0002224)3.58361096
27Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.42679928
28Oligodontia (HP:0000677)3.32247617
29Duplicated collecting system (HP:0000081)3.27998078
30Blepharitis (HP:0000498)3.26556166
31Abnormality of the distal phalanges of the toes (HP:0010182)3.13554051
32Parakeratosis (HP:0001036)3.12780069
33Abnormal hair laboratory examination (HP:0003328)3.04486245
34Popliteal pterygium (HP:0009756)3.01665545
35Abnormality of the renal collecting system (HP:0004742)2.97054794
36Hypoplastic labia majora (HP:0000059)2.93686862
37Palpitations (HP:0001962)2.93587580
38Pili torti (HP:0003777)2.90928723
39Selective tooth agenesis (HP:0001592)2.90564928
40Skin pits (HP:0100276)2.75987661
41Ureteral duplication (HP:0000073)2.74889705
42Abnormality of the labia majora (HP:0012881)2.72157344
43Milia (HP:0001056)2.68857894
44Paralysis (HP:0003470)2.67363730
45Multifactorial inheritance (HP:0001426)2.66643111
46Palmoplantar keratoderma (HP:0000982)2.65053977
47Xerostomia (HP:0000217)2.60702366
48Ridged nail (HP:0001807)2.57212517
49Pustule (HP:0200039)2.53400083
50Fragile nails (HP:0001808)2.49411509
51Trismus (HP:0000211)2.48534834
52Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.48084305
53Short 1st metacarpal (HP:0010034)2.48084305
54Septate vagina (HP:0001153)2.43414849
55Sparse scalp hair (HP:0002209)2.33174700
56Hypoplasia of dental enamel (HP:0006297)2.26720569
57Abnormalities of placenta or umbilical cord (HP:0001194)2.25143813
58Abnormality of the 1st metacarpal (HP:0010009)2.22482393
59Tongue fasciculations (HP:0001308)2.22451711
60Syncope (HP:0001279)2.19921676
61Stenosis of the external auditory canal (HP:0000402)2.18280250
62Reduced subcutaneous adipose tissue (HP:0003758)2.17560662
63Hypoplastic toenails (HP:0001800)2.16219161
64Abnormal blistering of the skin (HP:0008066)2.15308803
65Fragile skin (HP:0001030)2.11878254
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10747216
67Persistence of primary teeth (HP:0006335)2.10471451
68Autoamputation (HP:0001218)2.06040102
69Dehydration (HP:0001944)2.01612768
70Gangrene (HP:0100758)2.00140518
71Ankyloglossia (HP:0010296)1.99977180
72Breast hypoplasia (HP:0003187)1.97347763
73Hypoalphalipoproteinemia (HP:0003233)1.94738172
74Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90975917
75Muscle fibrillation (HP:0010546)1.90492528
76Vascular calcification (HP:0004934)1.88701837
77Polygenic inheritance (HP:0010982)1.88669698
78Acanthosis nigricans (HP:0000956)1.87796449
79Furrowed tongue (HP:0000221)1.86534919
80Atrophic scars (HP:0001075)1.86497815
81Pterygium (HP:0001059)1.85685042
82Recurrent corneal erosions (HP:0000495)1.85138855
83Wide intermamillary distance (HP:0006610)1.84334715
84Lack of skin elasticity (HP:0100679)1.82439673
85Pruritus (HP:0000989)1.81871511
86Brittle hair (HP:0002299)1.78866941
87Carious teeth (HP:0000670)1.77786559
88Abnormality of the preputium (HP:0100587)1.75270885
89Amelogenesis imperfecta (HP:0000705)1.72991730
90Hypoplastic female external genitalia (HP:0012815)1.72227702
91Anonychia (HP:0001798)1.70813004
92Labial hypoplasia (HP:0000066)1.70076283
93Fused cervical vertebrae (HP:0002949)1.68735634
94Abnormality of the dental root (HP:0006486)1.66982598
95Taurodontia (HP:0000679)1.66982598
96Abnormality of permanent molar morphology (HP:0011071)1.66982598
97Chromsome breakage (HP:0040012)1.65110276
98Slow-growing hair (HP:0002217)1.64951904
99Abnormality of hair growth rate (HP:0011363)1.64951904
100Cardiovascular calcification (HP:0011915)1.62826287

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA29.97620723
2BLK6.83877375
3MAP3K95.42703210
4MAP3K63.14207188
5PBK2.78339948
6STK242.69563993
7MST1R2.48456903
8PDK22.24480233
9MAP3K32.11997856
10MAP3K21.86650893
11MST41.64913837
12MAP3K121.54229450
13TGFBR11.48413253
14RIPK11.42655486
15CDK91.42407600
16SMG11.37241126
17FER1.29240676
18SCYL21.27749352
19BUB11.21499326
20MAPKAPK31.19118112
21TLK11.15132415
22RPS6KB21.14882114
23IRAK31.00539224
24VRK20.95445846
25STK38L0.92010554
26TESK10.89079848
27STK30.84847397
28MET0.84244566
29PTK20.78422513
30PAK40.77771094
31FGFR40.74559824
32TAOK10.70215962
33WEE10.68498949
34NME10.65683838
35MAP2K10.62300479
36TRIM280.62165337
37LATS10.61571433
38CDK120.59605799
39GRK10.59066527
40EIF2AK10.58591287
41CDC70.58100353
42FGFR10.58059272
43AURKB0.57901023
44DAPK30.57821823
45NME20.54611607
46IKBKB0.51708546
47PTK60.50275396
48EPHB10.48181921
49MELK0.46594632
50MAP3K10.46263225
51AURKA0.45543464
52CDK70.45416025
53ARAF0.45332886
54LMTK20.45100329
55ABL20.44115382
56EGFR0.43940585
57STK390.43273932
58VRK10.40966549
59ZAK0.37622552
60MAP2K60.35745860
61LATS20.35321486
62AKT20.33861004
63TAF10.32653702
64MAP2K20.31928387
65LIMK10.31320654
66CAMK2G0.31185744
67CDK60.30528170
68NEK10.30217995
69ERBB40.28483053
70PLK10.27975059
71FGFR30.26823861
72TESK20.26285921
73TSSK60.25195424
74RPS6KA40.23792550
75MAP3K80.22428960
76EPHB20.21810430
77CAMK2D0.21420929
78CSNK1A1L0.21266024
79EPHA30.20752499
80PIM20.20508978
81TBK10.19883899
82RPS6KB10.19298274
83DAPK10.18960171
84CSNK1G30.18775494
85STK100.17774248
86TTK0.17193753
87SGK2230.16923964
88SGK4940.16923964
89CAMK2B0.16773113
90ERN10.16706152
91RPS6KA50.16473130
92BRAF0.16108606
93ERBB30.15858677
94PAK10.14564901
95STK160.14125785
96MYLK0.13711752
97NEK20.13610679
98GRK60.13538690
99TAOK20.13200156
100BCR0.12891650

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.95544660
2Sulfur metabolism_Homo sapiens_hsa009203.65539955
3Galactose metabolism_Homo sapiens_hsa000523.16263433
4Fat digestion and absorption_Homo sapiens_hsa049752.73750473
5Proteasome_Homo sapiens_hsa030502.54742917
6Fructose and mannose metabolism_Homo sapiens_hsa000512.50490351
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48903618
8Pancreatic secretion_Homo sapiens_hsa049722.32502911
9Thyroid cancer_Homo sapiens_hsa052162.17725476
10Systemic lupus erythematosus_Homo sapiens_hsa053222.15516438
11Starch and sucrose metabolism_Homo sapiens_hsa005001.98415941
12DNA replication_Homo sapiens_hsa030301.92170548
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89433082
14Bladder cancer_Homo sapiens_hsa052191.88275792
15Sphingolipid metabolism_Homo sapiens_hsa006001.76737984
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70038875
17Protein digestion and absorption_Homo sapiens_hsa049741.68791043
18Vitamin digestion and absorption_Homo sapiens_hsa049771.62973749
19Pentose phosphate pathway_Homo sapiens_hsa000301.49717612
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43137627
21Tight junction_Homo sapiens_hsa045301.41330831
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39441840
23Glutathione metabolism_Homo sapiens_hsa004801.35982804
24Vibrio cholerae infection_Homo sapiens_hsa051101.31883877
25p53 signaling pathway_Homo sapiens_hsa041151.27005398
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24566720
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.24425145
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22771646
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18794909
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17910348
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.15127961
32TGF-beta signaling pathway_Homo sapiens_hsa043501.15108192
33Hippo signaling pathway_Homo sapiens_hsa043901.14558894
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12892422
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11749946
36Arachidonic acid metabolism_Homo sapiens_hsa005901.04526395
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.04221746
38Renin-angiotensin system_Homo sapiens_hsa046141.01359184
39Linoleic acid metabolism_Homo sapiens_hsa005910.97595550
40Folate biosynthesis_Homo sapiens_hsa007900.96623195
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96313420
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95847186
43Cell cycle_Homo sapiens_hsa041100.95005799
44Alcoholism_Homo sapiens_hsa050340.92011709
45Glycerolipid metabolism_Homo sapiens_hsa005610.89391796
46Steroid biosynthesis_Homo sapiens_hsa001000.88234326
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84555306
48Mismatch repair_Homo sapiens_hsa034300.82715092
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81422480
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80915489
51Shigellosis_Homo sapiens_hsa051310.80272922
52Ether lipid metabolism_Homo sapiens_hsa005650.79751397
53Carbon metabolism_Homo sapiens_hsa012000.79416149
54Hepatitis C_Homo sapiens_hsa051600.77334114
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77254647
56Fatty acid elongation_Homo sapiens_hsa000620.75367994
57ECM-receptor interaction_Homo sapiens_hsa045120.72415688
58Biosynthesis of amino acids_Homo sapiens_hsa012300.72197240
59Small cell lung cancer_Homo sapiens_hsa052220.71275519
60Chemical carcinogenesis_Homo sapiens_hsa052040.70755708
61Ovarian steroidogenesis_Homo sapiens_hsa049130.69649819
62Pyrimidine metabolism_Homo sapiens_hsa002400.67276254
63Inositol phosphate metabolism_Homo sapiens_hsa005620.66726155
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64697478
65Caffeine metabolism_Homo sapiens_hsa002320.64175920
66RNA transport_Homo sapiens_hsa030130.63722092
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.63491778
68Sulfur relay system_Homo sapiens_hsa041220.62472921
69Phenylalanine metabolism_Homo sapiens_hsa003600.60868383
70HIF-1 signaling pathway_Homo sapiens_hsa040660.59175069
71GnRH signaling pathway_Homo sapiens_hsa049120.56096570
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54233941
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.53406378
74Retinol metabolism_Homo sapiens_hsa008300.53236946
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53174077
76Viral carcinogenesis_Homo sapiens_hsa052030.53089718
77Adherens junction_Homo sapiens_hsa045200.53028311
78PPAR signaling pathway_Homo sapiens_hsa033200.52444573
79Histidine metabolism_Homo sapiens_hsa003400.50774625
80MicroRNAs in cancer_Homo sapiens_hsa052060.50001770
81Gastric acid secretion_Homo sapiens_hsa049710.49735216
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49321036
83Bile secretion_Homo sapiens_hsa049760.48595777
84Spliceosome_Homo sapiens_hsa030400.45731478
85Amoebiasis_Homo sapiens_hsa051460.45551216
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.44738811
87Proteoglycans in cancer_Homo sapiens_hsa052050.43748388
88Arginine and proline metabolism_Homo sapiens_hsa003300.43156108
89Collecting duct acid secretion_Homo sapiens_hsa049660.43016088
90Base excision repair_Homo sapiens_hsa034100.41617000
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41342262
92Oocyte meiosis_Homo sapiens_hsa041140.40868365
93Endocytosis_Homo sapiens_hsa041440.37564876
94Pyruvate metabolism_Homo sapiens_hsa006200.37227449
95Metabolic pathways_Homo sapiens_hsa011000.36824595
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36697406
97Arginine biosynthesis_Homo sapiens_hsa002200.33692333
98Tyrosine metabolism_Homo sapiens_hsa003500.33665859
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33400881
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32843173

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