

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 9.80998345 |
| 2 | desmosome organization (GO:0002934) | 8.85914176 |
| 3 | keratinization (GO:0031424) | 7.94348986 |
| 4 | establishment of skin barrier (GO:0061436) | 7.22349968 |
| 5 | keratinocyte differentiation (GO:0030216) | 7.18928337 |
| 6 | regulation of water loss via skin (GO:0033561) | 6.56948341 |
| 7 | peptide cross-linking (GO:0018149) | 6.50054948 |
| 8 | keratinocyte proliferation (GO:0043616) | 6.20716739 |
| 9 | ectoderm development (GO:0007398) | 6.09296220 |
| 10 | establishment of planar polarity (GO:0001736) | 5.92492492 |
| 11 | establishment of tissue polarity (GO:0007164) | 5.92492492 |
| 12 | epidermal cell differentiation (GO:0009913) | 5.88659179 |
| 13 | eyelid development in camera-type eye (GO:0061029) | 5.78878311 |
| 14 | keratinocyte development (GO:0003334) | 5.69819989 |
| 15 | hemidesmosome assembly (GO:0031581) | 5.38717498 |
| 16 | membrane protein ectodomain proteolysis (GO:0006509) | 5.13148410 |
| 17 | gap junction assembly (GO:0016264) | 4.97400257 |
| 18 | artery smooth muscle contraction (GO:0014824) | 4.83662945 |
| 19 | multicellular organismal water homeostasis (GO:0050891) | 4.61917573 |
| 20 | atrioventricular valve morphogenesis (GO:0003181) | 4.60157429 |
| 21 | negative regulation of keratinocyte proliferation (GO:0010839) | 4.55392642 |
| 22 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 4.52059719 |
| 23 | regulation of heart rate by cardiac conduction (GO:0086091) | 4.48832598 |
| 24 | positive regulation of p38MAPK cascade (GO:1900745) | 4.46587000 |
| 25 | regulation of keratinocyte proliferation (GO:0010837) | 4.43339349 |
| 26 | intestinal epithelial cell development (GO:0060576) | 4.40520654 |
| 27 | epidermis development (GO:0008544) | 4.28631681 |
| 28 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 4.22895646 |
| 29 | hair cycle (GO:0042633) | 4.16645246 |
| 30 | molting cycle (GO:0042303) | 4.16645246 |
| 31 | tonic smooth muscle contraction (GO:0014820) | 4.07519974 |
| 32 | lateral sprouting from an epithelium (GO:0060601) | 4.00460425 |
| 33 | interferon-gamma secretion (GO:0072643) | 3.97639620 |
| 34 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.92283490 |
| 35 | water homeostasis (GO:0030104) | 3.83165228 |
| 36 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 3.81761790 |
| 37 | regulation of keratinocyte differentiation (GO:0045616) | 3.79813297 |
| 38 | prostaglandin biosynthetic process (GO:0001516) | 3.79699772 |
| 39 | prostanoid biosynthetic process (GO:0046457) | 3.79699772 |
| 40 | positive regulation of epidermal cell differentiation (GO:0045606) | 3.74844199 |
| 41 | wound healing, spreading of epidermal cells (GO:0035313) | 3.69937374 |
| 42 | epithelial cell differentiation involved in prostate gland development (GO:0060742) | 3.69781723 |
| 43 | regulation of Wnt signaling pathway involved in heart development (GO:0003307) | 3.66379553 |
| 44 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 3.60835541 |
| 45 | transepithelial transport (GO:0070633) | 3.57801818 |
| 46 | negative regulation of epidermis development (GO:0045683) | 3.57763382 |
| 47 | negative regulation of epidermal cell differentiation (GO:0045605) | 3.53923464 |
| 48 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.48761487 |
| 49 | hepatocyte differentiation (GO:0070365) | 3.46563758 |
| 50 | inositol phosphate-mediated signaling (GO:0048016) | 3.46248991 |
| 51 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.45722189 |
| 52 | energy homeostasis (GO:0097009) | 3.44803144 |
| 53 | cardiac conduction (GO:0061337) | 3.43464385 |
| 54 | cell adhesion mediated by integrin (GO:0033627) | 3.43144108 |
| 55 | cellular potassium ion homeostasis (GO:0030007) | 3.41189454 |
| 56 | response to lipoprotein particle (GO:0055094) | 3.41134504 |
| 57 | activation of Rac GTPase activity (GO:0032863) | 3.37596401 |
| 58 | cellular protein complex localization (GO:0034629) | 3.34345090 |
| 59 | response to UV-B (GO:0010224) | 3.32885455 |
| 60 | membrane repolarization during action potential (GO:0086011) | 3.28749942 |
| 61 | polarized epithelial cell differentiation (GO:0030859) | 3.26647252 |
| 62 | regulation of cardioblast differentiation (GO:0051890) | 3.25927470 |
| 63 | membrane protein proteolysis (GO:0033619) | 3.25745575 |
| 64 | cardiac muscle cell action potential (GO:0086001) | 3.24617961 |
| 65 | surfactant homeostasis (GO:0043129) | 3.21419778 |
| 66 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 3.16388859 |
| 67 | regulation of somitogenesis (GO:0014807) | 3.16145660 |
| 68 | regulation of p38MAPK cascade (GO:1900744) | 3.09509619 |
| 69 | regulation of epidermal cell differentiation (GO:0045604) | 3.07775602 |
| 70 | positive regulation of Cdc42 GTPase activity (GO:0043089) | 3.04041684 |
| 71 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338) | 3.00178062 |
| 72 | regulation of cholesterol homeostasis (GO:2000188) | 2.99654091 |
| 73 | morphogenesis of an epithelial fold (GO:0060571) | 2.99362397 |
| 74 | positive regulation of epidermis development (GO:0045684) | 2.99309022 |
| 75 | negative regulation of protein localization to cell surface (GO:2000009) | 2.97153135 |
| 76 | prostanoid metabolic process (GO:0006692) | 2.94742405 |
| 77 | prostaglandin metabolic process (GO:0006693) | 2.94742405 |
| 78 | daunorubicin metabolic process (GO:0044597) | 2.94657279 |
| 79 | polyketide metabolic process (GO:0030638) | 2.94657279 |
| 80 | doxorubicin metabolic process (GO:0044598) | 2.94657279 |
| 81 | membrane protein intracellular domain proteolysis (GO:0031293) | 2.94001157 |
| 82 | chemical homeostasis within a tissue (GO:0048875) | 2.93844159 |
| 83 | mammary gland epithelial cell proliferation (GO:0033598) | 2.91463464 |
| 84 | cardiac right ventricle morphogenesis (GO:0003215) | 2.90866442 |
| 85 | glandular epithelial cell differentiation (GO:0002067) | 2.88383082 |
| 86 | epithelial cell-cell adhesion (GO:0090136) | 2.86463211 |
| 87 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.85463228 |
| 88 | regulation of protein localization to cell surface (GO:2000008) | 2.85155386 |
| 89 | negative regulation of protein tyrosine kinase activity (GO:0061099) | 2.79549958 |
| 90 | regulation of skeletal muscle contraction (GO:0014819) | 2.78604621 |
| 91 | regulation of epidermis development (GO:0045682) | 2.77973787 |
| 92 | nuclear envelope reassembly (GO:0031468) | 2.77669130 |
| 93 | mitotic nuclear envelope reassembly (GO:0007084) | 2.77669130 |
| 94 | intermediate filament cytoskeleton organization (GO:0045104) | 2.76928911 |
| 95 | post-anal tail morphogenesis (GO:0036342) | 2.73704797 |
| 96 | positive regulation of keratinocyte differentiation (GO:0045618) | 2.73413688 |
| 97 | intermediate filament organization (GO:0045109) | 2.72230258 |
| 98 | prostate gland epithelium morphogenesis (GO:0060740) | 2.67923271 |
| 99 | intermediate filament-based process (GO:0045103) | 2.65460297 |
| 100 | morphogenesis of embryonic epithelium (GO:0016331) | 2.63861605 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 8.77377875 |
| 2 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 7.80377585 |
| 3 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 5.16416765 |
| 4 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 4.79309319 |
| 5 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 4.01286606 |
| 6 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 3.25702314 |
| 7 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 3.23227591 |
| 8 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 3.20986793 |
| 9 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 3.20986793 |
| 10 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.06002472 |
| 11 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.91526513 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.67526320 |
| 13 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 2.51569547 |
| 14 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 2.50421261 |
| 15 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 2.49457809 |
| 16 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 2.30186870 |
| 17 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 2.18116137 |
| 18 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 2.07748198 |
| 19 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.98584825 |
| 20 | ATF3_27146783_Chip-Seq_COLON_Human | 1.90106324 |
| 21 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.88105648 |
| 22 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.87251844 |
| 23 | GATA6_25053715_ChIP-Seq_YYC3_Human | 1.85365129 |
| 24 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.62570745 |
| 25 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.62477349 |
| 26 | GATA4_25053715_ChIP-Seq_YYC3_Human | 1.61056083 |
| 27 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.59215482 |
| 28 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.57496987 |
| 29 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.56495912 |
| 30 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.53693590 |
| 31 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.53069145 |
| 32 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.48497704 |
| 33 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.48278625 |
| 34 | KLF5_25053715_ChIP-Seq_YYC3_Human | 1.48263042 |
| 35 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.47650567 |
| 36 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.46828819 |
| 37 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.45159701 |
| 38 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.42409529 |
| 39 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.41531019 |
| 40 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.40964155 |
| 41 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.39960358 |
| 42 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.35575776 |
| 43 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.34080601 |
| 44 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 1.32029050 |
| 45 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.31956471 |
| 46 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.31622468 |
| 47 | CJUN_26792858_Chip-Seq_BT549_Human | 1.30521046 |
| 48 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.28450040 |
| 49 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.23339442 |
| 50 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.22646775 |
| 51 | TP63_23658742_ChIP-Seq_EP156T_Human | 1.20733207 |
| 52 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.18279905 |
| 53 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.14065092 |
| 54 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.10911694 |
| 55 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.08651599 |
| 56 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.06727600 |
| 57 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.06726365 |
| 58 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.04165982 |
| 59 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.02934062 |
| 60 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.02787516 |
| 61 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.01723476 |
| 62 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.00206593 |
| 63 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.97652212 |
| 64 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 0.96914007 |
| 65 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.94288574 |
| 66 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.93427718 |
| 67 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.93147790 |
| 68 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.93005921 |
| 69 | RXR_22108803_ChIP-Seq_LS180_Human | 0.92101093 |
| 70 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.91631507 |
| 71 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.90862211 |
| 72 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.87424138 |
| 73 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.85975690 |
| 74 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.85542707 |
| 75 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 0.82272073 |
| 76 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.82173167 |
| 77 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.79864666 |
| 78 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.78829032 |
| 79 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.78816008 |
| 80 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.77634733 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.77587650 |
| 82 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.77152426 |
| 83 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.76973582 |
| 84 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.76697786 |
| 85 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.75892468 |
| 86 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.75770913 |
| 87 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.74942731 |
| 88 | NFYB_21822215_ChIP-Seq_K562_Human | 0.73086389 |
| 89 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.72390755 |
| 90 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.70104952 |
| 91 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.67988091 |
| 92 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.66477535 |
| 93 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.66106988 |
| 94 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.65944441 |
| 95 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.65510162 |
| 96 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.65280338 |
| 97 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 0.65179232 |
| 98 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.65047594 |
| 99 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.64409040 |
| 100 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.64369842 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002796_impaired_skin_barrier | 6.94481592 |
| 2 | MP0010234_abnormal_vibrissa_follicle | 6.02857175 |
| 3 | MP0003453_abnormal_keratinocyte_physiol | 4.10065031 |
| 4 | MP0005501_abnormal_skin_physiology | 4.01931163 |
| 5 | MP0000579_abnormal_nail_morphology | 3.98432985 |
| 6 | MP0005377_hearing/vestibular/ear_phenot | 3.62946512 |
| 7 | MP0003878_abnormal_ear_physiology | 3.62946512 |
| 8 | MP0010678_abnormal_skin_adnexa | 3.49916924 |
| 9 | MP0004264_abnormal_extraembryonic_tissu | 3.24986733 |
| 10 | MP0000383_abnormal_hair_follicle | 3.21298106 |
| 11 | MP0003941_abnormal_skin_development | 3.04208306 |
| 12 | MP0001216_abnormal_epidermal_layer | 2.97715060 |
| 13 | MP0003693_abnormal_embryo_hatching | 2.75054143 |
| 14 | MP0002060_abnormal_skin_morphology | 2.64244223 |
| 15 | MP0010771_integument_phenotype | 2.46888551 |
| 16 | MP0009053_abnormal_anal_canal | 2.37698471 |
| 17 | MP0000566_synostosis | 2.37596646 |
| 18 | MP0003315_abnormal_perineum_morphology | 2.36744814 |
| 19 | MP0002098_abnormal_vibrissa_morphology | 2.28679621 |
| 20 | MP0000467_abnormal_esophagus_morphology | 2.22793937 |
| 21 | MP0004885_abnormal_endolymph | 2.14368198 |
| 22 | MP0003566_abnormal_cell_adhesion | 2.13902238 |
| 23 | MP0003950_abnormal_plasma_membrane | 2.05472824 |
| 24 | MP0004043_abnormal_pH_regulation | 2.02991326 |
| 25 | MP0004185_abnormal_adipocyte_glucose | 1.90858943 |
| 26 | MP0000465_gastrointestinal_hemorrhage | 1.88745073 |
| 27 | MP0000537_abnormal_urethra_morphology | 1.88730444 |
| 28 | MP0003191_abnormal_cellular_cholesterol | 1.84894285 |
| 29 | MP0010352_gastrointestinal_tract_polyps | 1.83296550 |
| 30 | MP0004782_abnormal_surfactant_physiolog | 1.69279470 |
| 31 | MP0005670_abnormal_white_adipose | 1.68285930 |
| 32 | MP0005409_darkened_coat_color | 1.67334565 |
| 33 | MP0001849_ear_inflammation | 1.62977974 |
| 34 | MP0002877_abnormal_melanocyte_morpholog | 1.59872346 |
| 35 | MP0000377_abnormal_hair_follicle | 1.56347781 |
| 36 | MP0009780_abnormal_chondrocyte_physiolo | 1.53097771 |
| 37 | MP0005275_abnormal_skin_tensile | 1.52681958 |
| 38 | MP0004957_abnormal_blastocyst_morpholog | 1.43941979 |
| 39 | MP0003806_abnormal_nucleotide_metabolis | 1.40115435 |
| 40 | MP0000762_abnormal_tongue_morphology | 1.35114258 |
| 41 | MP0000427_abnormal_hair_cycle | 1.23047379 |
| 42 | MP0010030_abnormal_orbit_morphology | 1.15522106 |
| 43 | MP0001666_abnormal_nutrient_absorption | 1.15088913 |
| 44 | MP0001485_abnormal_pinna_reflex | 1.15026185 |
| 45 | MP0009840_abnormal_foam_cell | 1.12073047 |
| 46 | MP0009931_abnormal_skin_appearance | 1.10885031 |
| 47 | MP0004272_abnormal_basement_membrane | 1.07351497 |
| 48 | MP0002111_abnormal_tail_morphology | 1.06404340 |
| 49 | MP0008260_abnormal_autophagy | 1.06052815 |
| 50 | MP0002009_preneoplasia | 1.03973757 |
| 51 | MP0000627_abnormal_mammary_gland | 0.96105188 |
| 52 | MP0004381_abnormal_hair_follicle | 0.90153560 |
| 53 | MP0003705_abnormal_hypodermis_morpholog | 0.87440492 |
| 54 | MP0005076_abnormal_cell_differentiation | 0.84418479 |
| 55 | MP0005666_abnormal_adipose_tissue | 0.83853895 |
| 56 | MP0000647_abnormal_sebaceous_gland | 0.83478643 |
| 57 | MP0005023_abnormal_wound_healing | 0.83181543 |
| 58 | MP0005451_abnormal_body_composition | 0.82151752 |
| 59 | MP0001340_abnormal_eyelid_morphology | 0.79928557 |
| 60 | MP0002282_abnormal_trachea_morphology | 0.79195964 |
| 61 | MP0001851_eye_inflammation | 0.78557898 |
| 62 | MP0000367_abnormal_coat/_hair | 0.78532564 |
| 63 | MP0001191_abnormal_skin_condition | 0.76952900 |
| 64 | MP0000470_abnormal_stomach_morphology | 0.76529157 |
| 65 | MP0004019_abnormal_vitamin_homeostasis | 0.74565341 |
| 66 | MP0000477_abnormal_intestine_morphology | 0.71889046 |
| 67 | MP0005360_urolithiasis | 0.67911084 |
| 68 | MP0004947_skin_inflammation | 0.67857559 |
| 69 | MP0004197_abnormal_fetal_growth/weight/ | 0.66282820 |
| 70 | MP0000858_altered_metastatic_potential | 0.62763908 |
| 71 | MP0001697_abnormal_embryo_size | 0.62528017 |
| 72 | MP0000516_abnormal_urinary_system | 0.60965408 |
| 73 | MP0005367_renal/urinary_system_phenotyp | 0.60965408 |
| 74 | MP0002086_abnormal_extraembryonic_tissu | 0.60703124 |
| 75 | MP0000613_abnormal_salivary_gland | 0.57200129 |
| 76 | MP0000013_abnormal_adipose_tissue | 0.57015381 |
| 77 | MP0001765_abnormal_ion_homeostasis | 0.55728865 |
| 78 | MP0003937_abnormal_limbs/digits/tail_de | 0.54482182 |
| 79 | MP0001730_embryonic_growth_arrest | 0.52438146 |
| 80 | MP0005197_abnormal_uvea_morphology | 0.51496707 |
| 81 | MP0000678_abnormal_parathyroid_gland | 0.50176699 |
| 82 | MP0003119_abnormal_digestive_system | 0.49754686 |
| 83 | MP0002006_tumorigenesis | 0.49069951 |
| 84 | MP0010094_abnormal_chromosome_stability | 0.48456697 |
| 85 | MP0001784_abnormal_fluid_regulation | 0.48428382 |
| 86 | MP0003718_maternal_effect | 0.46005634 |
| 87 | MP0001672_abnormal_embryogenesis/_devel | 0.45176106 |
| 88 | MP0005380_embryogenesis_phenotype | 0.45176106 |
| 89 | MP0000350_abnormal_cell_proliferation | 0.45067141 |
| 90 | MP0002084_abnormal_developmental_patter | 0.44484092 |
| 91 | MP0003936_abnormal_reproductive_system | 0.41513402 |
| 92 | MP0005083_abnormal_biliary_tract | 0.40558444 |
| 93 | MP0005365_abnormal_bile_salt | 0.39630561 |
| 94 | MP0002088_abnormal_embryonic_growth/wei | 0.38191053 |
| 95 | MP0003984_embryonic_growth_retardation | 0.38094785 |
| 96 | MP0000490_abnormal_crypts_of | 0.37871225 |
| 97 | MP0001661_extended_life_span | 0.37662361 |
| 98 | MP0003755_abnormal_palate_morphology | 0.37441851 |
| 99 | MP0002080_prenatal_lethality | 0.36009587 |
| 100 | MP0001243_abnormal_dermal_layer | 0.35550224 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of nail color (HP:0100643) | 9.05398160 |
| 2 | Lip pit (HP:0100267) | 6.30068652 |
| 3 | Abnormality of secondary sexual hair (HP:0009888) | 6.14322661 |
| 4 | Abnormality of the axillary hair (HP:0100134) | 6.14322661 |
| 5 | Oral leukoplakia (HP:0002745) | 5.94309675 |
| 6 | Onycholysis (HP:0001806) | 5.82970310 |
| 7 | Alopecia of scalp (HP:0002293) | 5.55544300 |
| 8 | Congenital ichthyosiform erythroderma (HP:0007431) | 5.54916313 |
| 9 | Right ventricular cardiomyopathy (HP:0011663) | 5.53198583 |
| 10 | Erythroderma (HP:0001019) | 5.27258679 |
| 11 | Corneal erosion (HP:0200020) | 5.19870572 |
| 12 | Abnormality of the salivary glands (HP:0010286) | 5.12878427 |
| 13 | Palmoplantar hyperkeratosis (HP:0000972) | 4.90466175 |
| 14 | Plantar hyperkeratosis (HP:0007556) | 4.80012520 |
| 15 | Hypotrichosis (HP:0001006) | 4.76009787 |
| 16 | Palmar hyperkeratosis (HP:0010765) | 4.68488838 |
| 17 | Thick nail (HP:0001805) | 4.57571248 |
| 18 | Nail dystrophy (HP:0008404) | 4.55714166 |
| 19 | Sparse eyelashes (HP:0000653) | 4.19229983 |
| 20 | Amniotic constriction ring (HP:0009775) | 4.18922582 |
| 21 | Abnormality of placental membranes (HP:0011409) | 4.18922582 |
| 22 | Absent eyelashes (HP:0000561) | 4.06259634 |
| 23 | Ectropion (HP:0000656) | 3.94117786 |
| 24 | Hypohidrosis (HP:0000966) | 3.61383780 |
| 25 | Absent hair (HP:0002298) | 3.58625807 |
| 26 | Woolly hair (HP:0002224) | 3.58361096 |
| 27 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 3.42679928 |
| 28 | Oligodontia (HP:0000677) | 3.32247617 |
| 29 | Duplicated collecting system (HP:0000081) | 3.27998078 |
| 30 | Blepharitis (HP:0000498) | 3.26556166 |
| 31 | Abnormality of the distal phalanges of the toes (HP:0010182) | 3.13554051 |
| 32 | Parakeratosis (HP:0001036) | 3.12780069 |
| 33 | Abnormal hair laboratory examination (HP:0003328) | 3.04486245 |
| 34 | Popliteal pterygium (HP:0009756) | 3.01665545 |
| 35 | Abnormality of the renal collecting system (HP:0004742) | 2.97054794 |
| 36 | Hypoplastic labia majora (HP:0000059) | 2.93686862 |
| 37 | Palpitations (HP:0001962) | 2.93587580 |
| 38 | Pili torti (HP:0003777) | 2.90928723 |
| 39 | Selective tooth agenesis (HP:0001592) | 2.90564928 |
| 40 | Skin pits (HP:0100276) | 2.75987661 |
| 41 | Ureteral duplication (HP:0000073) | 2.74889705 |
| 42 | Abnormality of the labia majora (HP:0012881) | 2.72157344 |
| 43 | Milia (HP:0001056) | 2.68857894 |
| 44 | Paralysis (HP:0003470) | 2.67363730 |
| 45 | Multifactorial inheritance (HP:0001426) | 2.66643111 |
| 46 | Palmoplantar keratoderma (HP:0000982) | 2.65053977 |
| 47 | Xerostomia (HP:0000217) | 2.60702366 |
| 48 | Ridged nail (HP:0001807) | 2.57212517 |
| 49 | Pustule (HP:0200039) | 2.53400083 |
| 50 | Fragile nails (HP:0001808) | 2.49411509 |
| 51 | Trismus (HP:0000211) | 2.48534834 |
| 52 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 2.48084305 |
| 53 | Short 1st metacarpal (HP:0010034) | 2.48084305 |
| 54 | Septate vagina (HP:0001153) | 2.43414849 |
| 55 | Sparse scalp hair (HP:0002209) | 2.33174700 |
| 56 | Hypoplasia of dental enamel (HP:0006297) | 2.26720569 |
| 57 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.25143813 |
| 58 | Abnormality of the 1st metacarpal (HP:0010009) | 2.22482393 |
| 59 | Tongue fasciculations (HP:0001308) | 2.22451711 |
| 60 | Syncope (HP:0001279) | 2.19921676 |
| 61 | Stenosis of the external auditory canal (HP:0000402) | 2.18280250 |
| 62 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.17560662 |
| 63 | Hypoplastic toenails (HP:0001800) | 2.16219161 |
| 64 | Abnormal blistering of the skin (HP:0008066) | 2.15308803 |
| 65 | Fragile skin (HP:0001030) | 2.11878254 |
| 66 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.10747216 |
| 67 | Persistence of primary teeth (HP:0006335) | 2.10471451 |
| 68 | Autoamputation (HP:0001218) | 2.06040102 |
| 69 | Dehydration (HP:0001944) | 2.01612768 |
| 70 | Gangrene (HP:0100758) | 2.00140518 |
| 71 | Ankyloglossia (HP:0010296) | 1.99977180 |
| 72 | Breast hypoplasia (HP:0003187) | 1.97347763 |
| 73 | Hypoalphalipoproteinemia (HP:0003233) | 1.94738172 |
| 74 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.90975917 |
| 75 | Muscle fibrillation (HP:0010546) | 1.90492528 |
| 76 | Vascular calcification (HP:0004934) | 1.88701837 |
| 77 | Polygenic inheritance (HP:0010982) | 1.88669698 |
| 78 | Acanthosis nigricans (HP:0000956) | 1.87796449 |
| 79 | Furrowed tongue (HP:0000221) | 1.86534919 |
| 80 | Atrophic scars (HP:0001075) | 1.86497815 |
| 81 | Pterygium (HP:0001059) | 1.85685042 |
| 82 | Recurrent corneal erosions (HP:0000495) | 1.85138855 |
| 83 | Wide intermamillary distance (HP:0006610) | 1.84334715 |
| 84 | Lack of skin elasticity (HP:0100679) | 1.82439673 |
| 85 | Pruritus (HP:0000989) | 1.81871511 |
| 86 | Brittle hair (HP:0002299) | 1.78866941 |
| 87 | Carious teeth (HP:0000670) | 1.77786559 |
| 88 | Abnormality of the preputium (HP:0100587) | 1.75270885 |
| 89 | Amelogenesis imperfecta (HP:0000705) | 1.72991730 |
| 90 | Hypoplastic female external genitalia (HP:0012815) | 1.72227702 |
| 91 | Anonychia (HP:0001798) | 1.70813004 |
| 92 | Labial hypoplasia (HP:0000066) | 1.70076283 |
| 93 | Fused cervical vertebrae (HP:0002949) | 1.68735634 |
| 94 | Abnormality of the dental root (HP:0006486) | 1.66982598 |
| 95 | Taurodontia (HP:0000679) | 1.66982598 |
| 96 | Abnormality of permanent molar morphology (HP:0011071) | 1.66982598 |
| 97 | Chromsome breakage (HP:0040012) | 1.65110276 |
| 98 | Slow-growing hair (HP:0002217) | 1.64951904 |
| 99 | Abnormality of hair growth rate (HP:0011363) | 1.64951904 |
| 100 | Cardiovascular calcification (HP:0011915) | 1.62826287 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA2 | 9.97620723 |
| 2 | BLK | 6.83877375 |
| 3 | MAP3K9 | 5.42703210 |
| 4 | MAP3K6 | 3.14207188 |
| 5 | PBK | 2.78339948 |
| 6 | STK24 | 2.69563993 |
| 7 | MST1R | 2.48456903 |
| 8 | PDK2 | 2.24480233 |
| 9 | MAP3K3 | 2.11997856 |
| 10 | MAP3K2 | 1.86650893 |
| 11 | MST4 | 1.64913837 |
| 12 | MAP3K12 | 1.54229450 |
| 13 | TGFBR1 | 1.48413253 |
| 14 | RIPK1 | 1.42655486 |
| 15 | CDK9 | 1.42407600 |
| 16 | SMG1 | 1.37241126 |
| 17 | FER | 1.29240676 |
| 18 | SCYL2 | 1.27749352 |
| 19 | BUB1 | 1.21499326 |
| 20 | MAPKAPK3 | 1.19118112 |
| 21 | TLK1 | 1.15132415 |
| 22 | RPS6KB2 | 1.14882114 |
| 23 | IRAK3 | 1.00539224 |
| 24 | VRK2 | 0.95445846 |
| 25 | STK38L | 0.92010554 |
| 26 | TESK1 | 0.89079848 |
| 27 | STK3 | 0.84847397 |
| 28 | MET | 0.84244566 |
| 29 | PTK2 | 0.78422513 |
| 30 | PAK4 | 0.77771094 |
| 31 | FGFR4 | 0.74559824 |
| 32 | TAOK1 | 0.70215962 |
| 33 | WEE1 | 0.68498949 |
| 34 | NME1 | 0.65683838 |
| 35 | MAP2K1 | 0.62300479 |
| 36 | TRIM28 | 0.62165337 |
| 37 | LATS1 | 0.61571433 |
| 38 | CDK12 | 0.59605799 |
| 39 | GRK1 | 0.59066527 |
| 40 | EIF2AK1 | 0.58591287 |
| 41 | CDC7 | 0.58100353 |
| 42 | FGFR1 | 0.58059272 |
| 43 | AURKB | 0.57901023 |
| 44 | DAPK3 | 0.57821823 |
| 45 | NME2 | 0.54611607 |
| 46 | IKBKB | 0.51708546 |
| 47 | PTK6 | 0.50275396 |
| 48 | EPHB1 | 0.48181921 |
| 49 | MELK | 0.46594632 |
| 50 | MAP3K1 | 0.46263225 |
| 51 | AURKA | 0.45543464 |
| 52 | CDK7 | 0.45416025 |
| 53 | ARAF | 0.45332886 |
| 54 | LMTK2 | 0.45100329 |
| 55 | ABL2 | 0.44115382 |
| 56 | EGFR | 0.43940585 |
| 57 | STK39 | 0.43273932 |
| 58 | VRK1 | 0.40966549 |
| 59 | ZAK | 0.37622552 |
| 60 | MAP2K6 | 0.35745860 |
| 61 | LATS2 | 0.35321486 |
| 62 | AKT2 | 0.33861004 |
| 63 | TAF1 | 0.32653702 |
| 64 | MAP2K2 | 0.31928387 |
| 65 | LIMK1 | 0.31320654 |
| 66 | CAMK2G | 0.31185744 |
| 67 | CDK6 | 0.30528170 |
| 68 | NEK1 | 0.30217995 |
| 69 | ERBB4 | 0.28483053 |
| 70 | PLK1 | 0.27975059 |
| 71 | FGFR3 | 0.26823861 |
| 72 | TESK2 | 0.26285921 |
| 73 | TSSK6 | 0.25195424 |
| 74 | RPS6KA4 | 0.23792550 |
| 75 | MAP3K8 | 0.22428960 |
| 76 | EPHB2 | 0.21810430 |
| 77 | CAMK2D | 0.21420929 |
| 78 | CSNK1A1L | 0.21266024 |
| 79 | EPHA3 | 0.20752499 |
| 80 | PIM2 | 0.20508978 |
| 81 | TBK1 | 0.19883899 |
| 82 | RPS6KB1 | 0.19298274 |
| 83 | DAPK1 | 0.18960171 |
| 84 | CSNK1G3 | 0.18775494 |
| 85 | STK10 | 0.17774248 |
| 86 | TTK | 0.17193753 |
| 87 | SGK223 | 0.16923964 |
| 88 | SGK494 | 0.16923964 |
| 89 | CAMK2B | 0.16773113 |
| 90 | ERN1 | 0.16706152 |
| 91 | RPS6KA5 | 0.16473130 |
| 92 | BRAF | 0.16108606 |
| 93 | ERBB3 | 0.15858677 |
| 94 | PAK1 | 0.14564901 |
| 95 | STK16 | 0.14125785 |
| 96 | MYLK | 0.13711752 |
| 97 | NEK2 | 0.13610679 |
| 98 | GRK6 | 0.13538690 |
| 99 | TAOK2 | 0.13200156 |
| 100 | BCR | 0.12891650 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 4.95544660 |
| 2 | Sulfur metabolism_Homo sapiens_hsa00920 | 3.65539955 |
| 3 | Galactose metabolism_Homo sapiens_hsa00052 | 3.16263433 |
| 4 | Fat digestion and absorption_Homo sapiens_hsa04975 | 2.73750473 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 2.54742917 |
| 6 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 2.50490351 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.48903618 |
| 8 | Pancreatic secretion_Homo sapiens_hsa04972 | 2.32502911 |
| 9 | Thyroid cancer_Homo sapiens_hsa05216 | 2.17725476 |
| 10 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.15516438 |
| 11 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.98415941 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 1.92170548 |
| 13 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.89433082 |
| 14 | Bladder cancer_Homo sapiens_hsa05219 | 1.88275792 |
| 15 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.76737984 |
| 16 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.70038875 |
| 17 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.68791043 |
| 18 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.62973749 |
| 19 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.49717612 |
| 20 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.43137627 |
| 21 | Tight junction_Homo sapiens_hsa04530 | 1.41330831 |
| 22 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.39441840 |
| 23 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.35982804 |
| 24 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.31883877 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.27005398 |
| 26 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.24566720 |
| 27 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.24425145 |
| 28 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.22771646 |
| 29 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.18794909 |
| 30 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.17910348 |
| 31 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.15127961 |
| 32 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.15108192 |
| 33 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.14558894 |
| 34 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.12892422 |
| 35 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.11749946 |
| 36 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.04526395 |
| 37 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.04221746 |
| 38 | Renin-angiotensin system_Homo sapiens_hsa04614 | 1.01359184 |
| 39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.97595550 |
| 40 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.96623195 |
| 41 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.96313420 |
| 42 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.95847186 |
| 43 | Cell cycle_Homo sapiens_hsa04110 | 0.95005799 |
| 44 | Alcoholism_Homo sapiens_hsa05034 | 0.92011709 |
| 45 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.89391796 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.88234326 |
| 47 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.84555306 |
| 48 | Mismatch repair_Homo sapiens_hsa03430 | 0.82715092 |
| 49 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.81422480 |
| 50 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.80915489 |
| 51 | Shigellosis_Homo sapiens_hsa05131 | 0.80272922 |
| 52 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.79751397 |
| 53 | Carbon metabolism_Homo sapiens_hsa01200 | 0.79416149 |
| 54 | Hepatitis C_Homo sapiens_hsa05160 | 0.77334114 |
| 55 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.77254647 |
| 56 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.75367994 |
| 57 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.72415688 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72197240 |
| 59 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.71275519 |
| 60 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.70755708 |
| 61 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.69649819 |
| 62 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.67276254 |
| 63 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.66726155 |
| 64 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.64697478 |
| 65 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.64175920 |
| 66 | RNA transport_Homo sapiens_hsa03013 | 0.63722092 |
| 67 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.63491778 |
| 68 | Sulfur relay system_Homo sapiens_hsa04122 | 0.62472921 |
| 69 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.60868383 |
| 70 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.59175069 |
| 71 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.56096570 |
| 72 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.54233941 |
| 73 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.53406378 |
| 74 | Retinol metabolism_Homo sapiens_hsa00830 | 0.53236946 |
| 75 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.53174077 |
| 76 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53089718 |
| 77 | Adherens junction_Homo sapiens_hsa04520 | 0.53028311 |
| 78 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.52444573 |
| 79 | Histidine metabolism_Homo sapiens_hsa00340 | 0.50774625 |
| 80 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.50001770 |
| 81 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.49735216 |
| 82 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.49321036 |
| 83 | Bile secretion_Homo sapiens_hsa04976 | 0.48595777 |
| 84 | Spliceosome_Homo sapiens_hsa03040 | 0.45731478 |
| 85 | Amoebiasis_Homo sapiens_hsa05146 | 0.45551216 |
| 86 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.44738811 |
| 87 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.43748388 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.43156108 |
| 89 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.43016088 |
| 90 | Base excision repair_Homo sapiens_hsa03410 | 0.41617000 |
| 91 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.41342262 |
| 92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.40868365 |
| 93 | Endocytosis_Homo sapiens_hsa04144 | 0.37564876 |
| 94 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.37227449 |
| 95 | Metabolic pathways_Homo sapiens_hsa01100 | 0.36824595 |
| 96 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.36697406 |
| 97 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.33692333 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.33665859 |
| 99 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.33400881 |
| 100 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.32843173 |

