KRT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.99369151
2keratinization (GO:0031424)9.86667346
3bundle of His cell to Purkinje myocyte communication (GO:0086069)8.94977394
4establishment of skin barrier (GO:0061436)8.60684766
5endothelial cell chemotaxis (GO:0035767)8.18009985
6regulation of water loss via skin (GO:0033561)7.71562980
7keratinocyte proliferation (GO:0043616)7.43768411
8hair cycle (GO:0042633)7.39682668
9molting cycle (GO:0042303)7.39682668
10synaptic vesicle maturation (GO:0016188)6.39256050
11* intermediate filament organization (GO:0045109)6.32617345
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.81000083
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79593629
14regulation of synapse structural plasticity (GO:0051823)5.51859079
15locomotory exploration behavior (GO:0035641)5.42628785
16* epidermis development (GO:0008544)5.35426741
17keratinocyte differentiation (GO:0030216)5.16754795
18vocalization behavior (GO:0071625)5.07681455
19regulation of long-term neuronal synaptic plasticity (GO:0048169)5.07365131
20regulation of neuronal synaptic plasticity (GO:0048168)5.01187306
21* intermediate filament cytoskeleton organization (GO:0045104)4.94542481
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92048045
23regulation of glutamate receptor signaling pathway (GO:1900449)4.86961277
24prepulse inhibition (GO:0060134)4.84753206
25synaptic transmission, dopaminergic (GO:0001963)4.80759780
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.74750515
27* intermediate filament-based process (GO:0045103)4.74391465
28multicellular organismal water homeostasis (GO:0050891)4.74109390
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.70641384
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.66423151
31negative regulation of keratinocyte proliferation (GO:0010839)4.64147164
32cellular copper ion homeostasis (GO:0006878)4.51594277
33striatum development (GO:0021756)4.49780488
34synaptic vesicle exocytosis (GO:0016079)4.48677843
35neurotransmitter-gated ion channel clustering (GO:0072578)4.46818512
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.41570513
37synaptic vesicle docking involved in exocytosis (GO:0016081)4.39988132
38cell-cell junction maintenance (GO:0045217)4.38807289
39cell-substrate junction assembly (GO:0007044)4.36593573
40exploration behavior (GO:0035640)4.30980755
41auditory behavior (GO:0031223)4.28142322
42regulation of dendritic spine morphogenesis (GO:0061001)4.22409154
43positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.21616520
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.18533075
45regulation of excitatory postsynaptic membrane potential (GO:0060079)4.16330285
46tRNA methylation (GO:0030488)4.14876448
47response to amphetamine (GO:0001975)4.14644253
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.13571216
49neuron-neuron synaptic transmission (GO:0007270)4.11911306
50neuronal action potential propagation (GO:0019227)4.09936209
51epidermal cell differentiation (GO:0009913)4.09832878
52substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.06682273
53substrate-independent telencephalic tangential migration (GO:0021826)4.06682273
54adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.05762419
55regulation of synaptic vesicle exocytosis (GO:2000300)4.05268217
56gap junction assembly (GO:0016264)4.04680648
57negative regulation of inclusion body assembly (GO:0090084)4.04316764
58synaptic transmission, glutamatergic (GO:0035249)4.04040583
59adenosine receptor signaling pathway (GO:0001973)3.99938811
60positive regulation of neurotransmitter transport (GO:0051590)3.98408073
61long-term memory (GO:0007616)3.98016439
62behavioral fear response (GO:0001662)3.96870483
63behavioral defense response (GO:0002209)3.96870483
64regulation of synaptic plasticity (GO:0048167)3.96803909
65neurotransmitter secretion (GO:0007269)3.96509686
66dopamine receptor signaling pathway (GO:0007212)3.96294026
67neuromuscular process controlling balance (GO:0050885)3.96110526
68peripheral nervous system development (GO:0007422)3.95854990
69regulation of glutamate secretion (GO:0014048)3.95561731
70establishment of tissue polarity (GO:0007164)3.94458258
71establishment of planar polarity (GO:0001736)3.94458258
72regulation of female receptivity (GO:0045924)3.93918467
73glutamate secretion (GO:0014047)3.93539957
74protein localization to synapse (GO:0035418)3.92128383
75synapsis (GO:0007129)3.91640984
76dendritic spine morphogenesis (GO:0060997)3.89180718
77long-term synaptic potentiation (GO:0060291)3.88365476
78glutamate receptor signaling pathway (GO:0007215)3.87880822
79water homeostasis (GO:0030104)3.87583299
80positive regulation of epidermis development (GO:0045684)3.86782593
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.85902724
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85774321
83cell junction maintenance (GO:0034331)3.83724032
84copper ion homeostasis (GO:0055070)3.82093629
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.81493061
86regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.81493061
87response to auditory stimulus (GO:0010996)3.80789023
88regulation of postsynaptic membrane potential (GO:0060078)3.79599769
89urogenital system development (GO:0001655)3.79116897
90neuronal ion channel clustering (GO:0045161)3.78393439
91positive regulation of membrane potential (GO:0045838)3.78068349
92regulation of synaptic transmission, glutamatergic (GO:0051966)3.78007375
93positive regulation of T cell differentiation in thymus (GO:0033089)3.77076385
94polarized epithelial cell differentiation (GO:0030859)3.76541101
95keratinocyte development (GO:0003334)3.74897438
96cellular response to gonadotropin stimulus (GO:0071371)3.72993638
97regulation of ruffle assembly (GO:1900027)3.71241470
98establishment of epithelial cell polarity (GO:0090162)3.69612435
99response to histamine (GO:0034776)3.68153985
100transmission of nerve impulse (GO:0019226)3.65222541
101regulation of synaptic vesicle transport (GO:1902803)3.65136519
102righting reflex (GO:0060013)3.65004379
103peptide cross-linking (GO:0018149)3.63617518
104regulation of keratinocyte proliferation (GO:0010837)3.61744892
105atrioventricular valve morphogenesis (GO:0003181)3.61355181
106startle response (GO:0001964)3.61029919
107chemical homeostasis within a tissue (GO:0048875)3.58723471
108negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.57216563
109positive regulation of neurotransmitter secretion (GO:0001956)3.56952218
110fear response (GO:0042596)3.56004014
111female mating behavior (GO:0060180)3.54288244
112behavioral response to cocaine (GO:0048148)3.52035015
113cellular potassium ion homeostasis (GO:0030007)3.50870327
114negative regulation of amino acid transport (GO:0051956)3.48291723
115regulation of axon regeneration (GO:0048679)3.47862582
116regulation of neuron projection regeneration (GO:0070570)3.47862582
117visual learning (GO:0008542)3.47763420
118mating behavior (GO:0007617)3.46217935
119negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44225895
120neuromuscular process controlling posture (GO:0050884)3.41450324
121epithelial cell-cell adhesion (GO:0090136)3.40789901
122proline transport (GO:0015824)3.40112056
123regulation of neurotransmitter uptake (GO:0051580)3.38881935
124dendritic spine organization (GO:0097061)3.33016636
125surfactant homeostasis (GO:0043129)3.31142285
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28186547
127gamma-aminobutyric acid transport (GO:0015812)3.27653731
128visual behavior (GO:0007632)3.26262297
129regulation of heart rate by cardiac conduction (GO:0086091)3.25918628
130membrane depolarization (GO:0051899)3.25789079
131learning (GO:0007612)3.23369400
132positive regulation of synaptic transmission (GO:0050806)3.23209553
133membrane hyperpolarization (GO:0060081)3.23041759
134urinary tract smooth muscle contraction (GO:0014848)3.22177414
135neuroblast proliferation (GO:0007405)3.21128370
136positive regulation of epidermal cell differentiation (GO:0045606)3.21105315
137regulation of synaptic transmission, dopaminergic (GO:0032225)3.20002219
138sodium ion export (GO:0071436)3.19882456
139regulation of dendritic spine development (GO:0060998)3.19532783
140positive regulation of dendritic spine morphogenesis (GO:0061003)3.18637280
141mammary gland epithelial cell differentiation (GO:0060644)3.17102405
142cAMP catabolic process (GO:0006198)3.16129758
143neuromuscular process (GO:0050905)3.15099040
144activation of protein kinase A activity (GO:0034199)3.14713598
145mechanosensory behavior (GO:0007638)3.14247124
146response to gonadotropin (GO:0034698)3.12126168
147regulation of gamma-delta T cell differentiation (GO:0045586)3.11546742
148cell morphogenesis involved in neuron differentiation (GO:0048667)3.10762866
149regulation of neurotransmitter transport (GO:0051588)3.10238373
150long term synaptic depression (GO:0060292)3.09693625
151neurotransmitter transport (GO:0006836)3.08711973
152regulation of neurotransmitter levels (GO:0001505)3.05877651
153membrane depolarization during action potential (GO:0086010)3.05570533
154regulation of vesicle fusion (GO:0031338)3.04864119
155endosome organization (GO:0007032)3.03391407
156renal filtration (GO:0097205)3.03348506
157regulation of neurotransmitter secretion (GO:0046928)3.02784679
158layer formation in cerebral cortex (GO:0021819)3.02327262
159phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.01965310
160ventricular cardiac muscle cell action potential (GO:0086005)3.01197909
161positive regulation of hair cycle (GO:0042635)3.00333250
162positive regulation of hair follicle development (GO:0051798)3.00333250
163protein refolding (GO:0042026)2.98277679
164notochord development (GO:0030903)2.97131981
165cell migration involved in sprouting angiogenesis (GO:0002042)2.92455051
166long-chain fatty acid biosynthetic process (GO:0042759)2.85112943
167cellular component maintenance (GO:0043954)2.84378419
168regulation of cell proliferation involved in kidney development (GO:1901722)2.81325343
169acrosome assembly (GO:0001675)2.79141455
170regulation of hair follicle development (GO:0051797)2.75409265
171regulation of epidermis development (GO:0045682)2.72580882
172protein localization to cytoskeleton (GO:0044380)2.69457396
173L-serine transport (GO:0015825)2.68715308
174positive regulation of keratinocyte differentiation (GO:0045618)2.68048068
175fucose catabolic process (GO:0019317)2.67198307
176L-fucose metabolic process (GO:0042354)2.67198307
177L-fucose catabolic process (GO:0042355)2.67198307
178translesion synthesis (GO:0019985)2.67067911
179* epithelium development (GO:0060429)2.66800936
180regulation of T cell differentiation in thymus (GO:0033081)2.66508757
181toxin metabolic process (GO:0009404)2.65693762
182glycine transport (GO:0015816)2.65101085
183multicellular organismal movement (GO:0050879)2.61989848
184musculoskeletal movement (GO:0050881)2.61989848
185ectoderm development (GO:0007398)2.60080768
186planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59636476
187receptor recycling (GO:0001881)2.59001389
188male meiosis I (GO:0007141)2.56507562
189fatty acid elongation (GO:0030497)2.55165151
190* skin development (GO:0043588)2.55128346
191plasma membrane repair (GO:0001778)2.51842766
192cardiac conduction (GO:0061337)2.51571420
193cell communication involved in cardiac conduction (GO:0086065)2.51068539
194trophoblast giant cell differentiation (GO:0060707)2.50447333
195Sertoli cell development (GO:0060009)2.49783319
196focal adhesion assembly (GO:0048041)2.49171190
197cell-substrate adherens junction assembly (GO:0007045)2.49171190
198regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48827398
199desmosome organization (GO:0002934)12.2996777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15403744
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58331101
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.50434011
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26596925
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.23710134
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.09062761
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07556726
8GBX2_23144817_ChIP-Seq_PC3_Human3.02643817
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.91954560
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.90827768
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86696718
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86696718
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.79386851
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77898011
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75945094
16DROSHA_22980978_ChIP-Seq_HELA_Human2.73256032
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.67206033
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64575858
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63839696
20REST_21632747_ChIP-Seq_MESCs_Mouse2.57686714
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.53391354
22* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.50777695
23* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.50777695
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47713271
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.46089827
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43298351
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42212641
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41211219
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.29491080
30SOX9_24532713_ChIP-Seq_HFSC_Mouse2.26977075
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.22705315
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.20734914
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.15379079
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14392757
35ERG_21242973_ChIP-ChIP_JURKAT_Human2.02391388
36TP63_17297297_ChIP-ChIP_HaCaT_Human13.4213827
37ZNF263_19887448_ChIP-Seq_K562_Human1.95650412
38* TP63_22573176_ChIP-Seq_HFKS_Human1.90159124
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87291906
40KLF5_25053715_ChIP-Seq_YYC3_Human1.82463620
41AR_21572438_ChIP-Seq_LNCaP_Human1.77654875
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76225767
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74712569
44TP63_23658742_ChIP-Seq_EP156T_Human1.57908534
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52701653
46ATF3_27146783_Chip-Seq_COLON_Human1.52627626
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50935687
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.46606682
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43044094
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42022500
51SMAD4_21799915_ChIP-Seq_A2780_Human1.38668388
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37264770
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.34560013
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.33390462
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32344073
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30449148
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30060790
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29492632
59ESR1_20079471_ChIP-ChIP_T-47D_Human1.28588323
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27392933
61KDM2B_26808549_Chip-Seq_K562_Human1.27350189
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27029404
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26826140
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26290990
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26050314
66TP53_18474530_ChIP-ChIP_U2OS_Human1.25820751
67SMC4_20622854_ChIP-Seq_HELA_Human1.23599918
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22339768
69* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21667160
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21631161
71RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20880559
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20231087
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.18288170
74LXR_22292898_ChIP-Seq_THP-1_Human1.17893687
75TAF15_26573619_Chip-Seq_HEK293_Human1.17273646
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17123814
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16983747
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.16969587
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16845197
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.16747990
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15694844
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15650328
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.15486006
84* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13971756
85AR_19668381_ChIP-Seq_PC3_Human1.13451286
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11942421
87CTCF_27219007_Chip-Seq_Bcells_Human1.11429832
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.09750545
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09633374
90AR_25329375_ChIP-Seq_VCAP_Human1.08529438
91P300_19829295_ChIP-Seq_ESCs_Human1.08468023
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08464314
93CJUN_26792858_Chip-Seq_BT549_Human1.07359546
94* STAT3_23295773_ChIP-Seq_U87_Human1.05475124
95RXR_22108803_ChIP-Seq_LS180_Human1.04924293
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03156958
97GATA4_25053715_ChIP-Seq_YYC3_Human1.02958194
98RACK7_27058665_Chip-Seq_MCF-7_Human1.01820062
99GATA3_24758297_ChIP-Seq_MCF-7_Human1.01817228
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00872718
101E2F1_20622854_ChIP-Seq_HELA_Human1.00510402
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00324622
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99724933
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99554767
105* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99538154
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.99285987
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97623588
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96878808
109ZNF274_21170338_ChIP-Seq_K562_Hela0.96740951
110ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96407231
111AHR_22903824_ChIP-Seq_MCF-7_Human0.95811754
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95509697
113PHF8_20622854_ChIP-Seq_HELA_Human0.95164744
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94375099
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.93926057
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93805696
117TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93487363
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93080650
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92939621
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92819916
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92704992
122TCF4_23295773_ChIP-Seq_U87_Human0.91538474
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.90279987
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89906564
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.89614828
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.89093968
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.89071818
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.88895923
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88076391
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87964933
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86695273
132TET1_21490601_ChIP-Seq_MESCs_Mouse0.86646987
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86358338
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85987097
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84883810
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84532526
137E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84353986
138RUNX2_22187159_ChIP-Seq_PCA_Human0.84121021
139P68_20966046_ChIP-Seq_HELA_Human0.83571212
140TP53_22127205_ChIP-Seq_IMR90_Human0.83156566
141CTCF_20526341_ChIP-Seq_ESCs_Human0.82537447
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82348766
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82099628
144TP53_16413492_ChIP-PET_HCT116_Human0.81629594
145EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81276502
146SMAD4_21741376_ChIP-Seq_EPCs_Human0.81133733
147BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80915181
148SOX2_20726797_ChIP-Seq_SW620_Human0.80757773
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79413140
150RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78966800
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.78862359
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.78815347
153BCOR_27268052_Chip-Seq_Bcells_Human0.78068346
154KDM2B_26808549_Chip-Seq_SUP-B15_Human0.77867470
155HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77720643
156SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.77440726
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.76751693
158TP53_23651856_ChIP-Seq_MEFs_Mouse0.75152895
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74588866
160CEBPB_22108803_ChIP-Seq_LS180_Human0.74040448
161OCT4_19829295_ChIP-Seq_ESCs_Human0.71416485
162CREB1_26743006_Chip-Seq_LNCaP_Human0.71185695
163AR_21909140_ChIP-Seq_LNCAP_Human0.71046666
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.69547224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.37370610
2MP0000579_abnormal_nail_morphology7.49259277
3MP0004859_abnormal_synaptic_plasticity7.24322456
4MP0002796_impaired_skin_barrier5.03207797
5MP0003635_abnormal_synaptic_transmissio4.16576781
6MP0003880_abnormal_central_pattern4.11886962
7MP0003878_abnormal_ear_physiology3.87095522
8MP0005377_hearing/vestibular/ear_phenot3.87095522
9MP0009745_abnormal_behavioral_response3.79578136
10MP0003941_abnormal_skin_development3.77695060
11MP0002063_abnormal_learning/memory/cond3.53182533
12MP0002098_abnormal_vibrissa_morphology3.45996134
13MP0005275_abnormal_skin_tensile3.38006026
14MP0004270_analgesia3.27987562
15MP0003705_abnormal_hypodermis_morpholog3.18277829
16MP0005501_abnormal_skin_physiology3.10378047
17MP0002064_seizures3.08809051
18MP0000566_synostosis2.98628921
19MP0002572_abnormal_emotion/affect_behav2.80646982
20MP0010678_abnormal_skin_adnexa2.65308133
21MP0000383_abnormal_hair_follicle2.62624347
22MP0004264_abnormal_extraembryonic_tissu2.59989275
23MP0004381_abnormal_hair_follicle2.58608502
24MP0009046_muscle_twitch2.57052543
25MP0001216_abnormal_epidermal_layer2.53993911
26MP0002272_abnormal_nervous_system2.48443178
27MP0001529_abnormal_vocalization2.47320303
28MP0002060_abnormal_skin_morphology2.46613012
29MP0001486_abnormal_startle_reflex2.43715448
30MP0001501_abnormal_sleep_pattern2.39722565
31MP0000762_abnormal_tongue_morphology2.38756469
32MP0003453_abnormal_keratinocyte_physiol2.34419921
33MP0001968_abnormal_touch/_nociception2.24474537
34MP0000467_abnormal_esophagus_morphology2.22439441
35MP0010771_integument_phenotype2.14637942
36MP0002735_abnormal_chemical_nociception2.11065842
37MP0002734_abnormal_mechanical_nocicepti2.08972194
38MP0000377_abnormal_hair_follicle2.08669685
39MP0002909_abnormal_adrenal_gland2.08195076
40MP0005423_abnormal_somatic_nervous2.01926149
41MP0000427_abnormal_hair_cycle2.00285251
42MP0005646_abnormal_pituitary_gland1.96712908
43MP0000647_abnormal_sebaceous_gland1.95620610
44MP0002733_abnormal_thermal_nociception1.84256785
45MP0003879_abnormal_hair_cell1.83544789
46MP0001970_abnormal_pain_threshold1.80559102
47MP0003566_abnormal_cell_adhesion1.77622993
48MP0004742_abnormal_vestibular_system1.75534633
49MP0008569_lethality_at_weaning1.71294940
50MP0004924_abnormal_behavior1.68140070
51MP0005386_behavior/neurological_phenoty1.68140070
52MP0003329_amyloid_beta_deposits1.65802249
53MP0001440_abnormal_grooming_behavior1.63161938
54MP0002736_abnormal_nociception_after1.63121296
55MP0003950_abnormal_plasma_membrane1.62895432
56MP0004811_abnormal_neuron_physiology1.61749296
57MP0009053_abnormal_anal_canal1.61049594
58MP0002876_abnormal_thyroid_physiology1.60844240
59MP0002234_abnormal_pharynx_morphology1.58928609
60MP0002254_reproductive_system_inflammat1.58351109
61MP0000537_abnormal_urethra_morphology1.57424502
62MP0001958_emphysema1.56625326
63MP0003075_altered_response_to1.55443619
64MP0002557_abnormal_social/conspecific_i1.52629790
65MP0009780_abnormal_chondrocyte_physiolo1.48362707
66MP0002067_abnormal_sensory_capabilities1.43623645
67MP0004782_abnormal_surfactant_physiolog1.42085029
68MP0001905_abnormal_dopamine_level1.33587551
69MP0002184_abnormal_innervation1.33311179
70MP0003315_abnormal_perineum_morphology1.31135074
71MP0004858_abnormal_nervous_system1.30902362
72MP0005645_abnormal_hypothalamus_physiol1.30339709
73MP0010234_abnormal_vibrissa_follicle1.30056543
74MP0009931_abnormal_skin_appearance1.27896520
75MP0008872_abnormal_physiological_respon1.27758177
76MP0001984_abnormal_olfaction1.26659618
77MP0002066_abnormal_motor_capabilities/c1.25629525
78MP0008874_decreased_physiological_sensi1.25226998
79MP0003633_abnormal_nervous_system1.21174474
80MP0001346_abnormal_lacrimal_gland1.19461801
81MP0005023_abnormal_wound_healing1.18193307
82MP0000955_abnormal_spinal_cord1.17016467
83MP0005409_darkened_coat_color1.13474436
84MP0002882_abnormal_neuron_morphology1.10938733
85MP0000367_abnormal_coat/_hair1.10303238
86MP0004885_abnormal_endolymph1.08074088
87MP0000778_abnormal_nervous_system1.07990531
88MP0002069_abnormal_eating/drinking_beha1.06328583
89MP0001340_abnormal_eyelid_morphology1.01719661
90MP0004185_abnormal_adipocyte_glucose1.01347574
91MP0002697_abnormal_eye_size0.99865659
92MP0005167_abnormal_blood-brain_barrier0.99342855
93MP0001177_atelectasis0.99121027
94MP0003787_abnormal_imprinting0.98942450
95MP0004947_skin_inflammation0.97990567
96MP0001502_abnormal_circadian_rhythm0.97823274
97MP0002877_abnormal_melanocyte_morpholog0.96755352
98MP0003631_nervous_system_phenotype0.96543558
99MP0008961_abnormal_basal_metabolism0.95255586
100MP0000751_myopathy0.92725339
101MP0004085_abnormal_heartbeat0.92405326
102MP0001348_abnormal_lacrimal_gland0.90135889
103MP0001188_hyperpigmentation0.89612436
104MP0005408_hypopigmentation0.89605823
105MP0004510_myositis0.87990006
106MP0005535_abnormal_body_temperature0.87883376
107MP0000627_abnormal_mammary_gland0.85505781
108MP0005310_abnormal_salivary_gland0.82697699
109MP0002152_abnormal_brain_morphology0.81480997
110MP0000604_amyloidosis0.81471367
111MP0001191_abnormal_skin_condition0.80428662
112MP0000569_abnormal_digit_pigmentation0.80392396
113MP0001243_abnormal_dermal_layer0.80352658
114MP0005410_abnormal_fertilization0.80287571
115MP0006276_abnormal_autonomic_nervous0.79650338
116MP0003690_abnormal_glial_cell0.78318449
117MP0003718_maternal_effect0.77453084
118MP0009379_abnormal_foot_pigmentation0.76967548
119MP0000013_abnormal_adipose_tissue0.76921246
120MP0003283_abnormal_digestive_organ0.75110233
121MP0004019_abnormal_vitamin_homeostasis0.72792344
122MP0002111_abnormal_tail_morphology0.70588014
123MP0010307_abnormal_tumor_latency0.70578492
124MP0000920_abnormal_myelination0.70195972
125MP0004142_abnormal_muscle_tone0.68223819
126MP0003137_abnormal_impulse_conducting0.67764324
127MP0002090_abnormal_vision0.67392737
128MP0003755_abnormal_palate_morphology0.66898127
129MP0001485_abnormal_pinna_reflex0.64096388
130MP0002229_neurodegeneration0.63610592
131MP0003172_abnormal_lysosome_physiology0.58538892
132MP0005503_abnormal_tendon_morphology0.58086333
133MP0004272_abnormal_basement_membrane0.56833959
134MP0005083_abnormal_biliary_tract0.56762168
135MP0003806_abnormal_nucleotide_metabolis0.56380225
136MP0003632_abnormal_nervous_system0.55625119
137MP0005076_abnormal_cell_differentiation0.55383826
138MP0005166_decreased_susceptibility_to0.54852948
139MP0001664_abnormal_digestion0.54377609
140MP0004957_abnormal_blastocyst_morpholog0.52555202
141MP0005499_abnormal_olfactory_system0.52483143
142MP0005394_taste/olfaction_phenotype0.52483143
143MP0000026_abnormal_inner_ear0.52154629
144MP0002249_abnormal_larynx_morphology0.51819550
145MP0008875_abnormal_xenobiotic_pharmacok0.50783695
146MP0010386_abnormal_urinary_bladder0.49943412
147MP0003634_abnormal_glial_cell0.49550980
148MP0001849_ear_inflammation0.49251962
149MP0003115_abnormal_respiratory_system0.48944376
150MP0005448_abnormal_energy_balance0.48291049
151MP0001963_abnormal_hearing_physiology0.47871028
152MP0000432_abnormal_head_morphology0.47597140
153MP0003045_fibrosis0.46544294
154MP0000534_abnormal_ureter_morphology0.43775158
155MP0005623_abnormal_meninges_morphology0.43624911
156MP0002752_abnormal_somatic_nervous0.43412421
157MP0003183_abnormal_peptide_metabolism0.42822680
158MP0000631_abnormal_neuroendocrine_gland0.42592699
159MP0003122_maternal_imprinting0.42572290
160MP0004215_abnormal_myocardial_fiber0.41970165
161MP0003646_muscle_fatigue0.41883842
162MP0003956_abnormal_body_size0.41359341
163MP0001881_abnormal_mammary_gland0.41155683
164MP0001943_abnormal_respiration0.38891305
165MP0003698_abnormal_male_reproductive0.38770598
166MP0005451_abnormal_body_composition0.38175721
167MP0005620_abnormal_muscle_contractility0.37831632
168MP0001929_abnormal_gametogenesis0.37389178
169MP0001765_abnormal_ion_homeostasis0.36490753
170MP0002896_abnormal_bone_mineralization0.36269465
171MP0002095_abnormal_skin_pigmentation0.35927874
172MP0003638_abnormal_response/metabolism_0.34862416
173MP0000516_abnormal_urinary_system0.34768547
174MP0005367_renal/urinary_system_phenotyp0.34768547
175MP0002282_abnormal_trachea_morphology0.33029556
176MP0000678_abnormal_parathyroid_gland0.30256435
177MP0003136_yellow_coat_color0.30179605
178MP0003937_abnormal_limbs/digits/tail_de0.30069189
179MP0002133_abnormal_respiratory_system0.27180288

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.72506679
2Abnormality of nail color (HP:0100643)9.55281899
3Focal motor seizures (HP:0011153)8.34028346
4* Plantar hyperkeratosis (HP:0007556)7.08850340
5* Palmoplantar hyperkeratosis (HP:0000972)6.74700882
6Onycholysis (HP:0001806)6.54189374
7* Palmar hyperkeratosis (HP:0010765)6.30003990
8Focal seizures (HP:0007359)6.18938403
9Milia (HP:0001056)5.72038699
10Thick nail (HP:0001805)5.56921059
11Annular pancreas (HP:0001734)5.49934607
12Pili torti (HP:0003777)5.33715453
13Fragile nails (HP:0001808)5.31022764
14Alopecia of scalp (HP:0002293)5.03308913
15Right ventricular cardiomyopathy (HP:0011663)4.85917054
16Woolly hair (HP:0002224)4.80685098
17Nail dystrophy (HP:0008404)4.50919161
18Hypotrichosis (HP:0001006)4.49750195
19Visual hallucinations (HP:0002367)4.45471458
20Abnormal hair laboratory examination (HP:0003328)4.31150025
21Torticollis (HP:0000473)4.26985204
22Action tremor (HP:0002345)4.14009996
23Oral leukoplakia (HP:0002745)4.08808603
24Epileptic encephalopathy (HP:0200134)4.00239577
25Anxiety (HP:0000739)3.95622967
26Impaired vibration sensation in the lower limbs (HP:0002166)3.83607261
27Hypoplastic labia majora (HP:0000059)3.81902675
28Febrile seizures (HP:0002373)3.80429048
29Generalized tonic-clonic seizures (HP:0002069)3.80045411
30Focal dystonia (HP:0004373)3.75097866
31Atonic seizures (HP:0010819)3.73815738
32Absence seizures (HP:0002121)3.73169403
33Ridged nail (HP:0001807)3.69609132
34Poor eye contact (HP:0000817)3.65058184
35Depression (HP:0000716)3.63544100
36Craniofacial dystonia (HP:0012179)3.57496843
37Dialeptic seizures (HP:0011146)3.53889808
38Congenital ichthyosiform erythroderma (HP:0007431)3.52781569
39Amelogenesis imperfecta (HP:0000705)3.48920037
40Gaze-evoked nystagmus (HP:0000640)3.48700009
41Dysdiadochokinesis (HP:0002075)3.48260837
42Abnormal blistering of the skin (HP:0008066)3.47351681
43Abnormality of the labia majora (HP:0012881)3.44054194
44Impaired social interactions (HP:0000735)3.43194369
45Abnormal social behavior (HP:0012433)3.43194369
46Ankle clonus (HP:0011448)3.42736252
47Resting tremor (HP:0002322)3.40550627
48Atrophic scars (HP:0001075)3.39764241
49Corneal erosion (HP:0200020)3.36327823
50Absent eyelashes (HP:0000561)3.31789094
51Progressive cerebellar ataxia (HP:0002073)3.25944523
52Sparse scalp hair (HP:0002209)3.22151479
53Dysmetria (HP:0001310)3.20129596
54Dysmetric saccades (HP:0000641)3.18103969
55Broad-based gait (HP:0002136)3.14577793
56Stereotypic behavior (HP:0000733)3.14367978
57Ankyloglossia (HP:0010296)3.13937996
58Erythroderma (HP:0001019)3.08722918
59Supranuclear gaze palsy (HP:0000605)2.99853925
60Postural instability (HP:0002172)2.97577317
61Erythema (HP:0010783)2.96813015
62Natal tooth (HP:0000695)2.96707875
63Pointed chin (HP:0000307)2.96190454
64Urinary bladder sphincter dysfunction (HP:0002839)2.96114938
65Sparse eyelashes (HP:0000653)2.96003052
66* Palmoplantar keratoderma (HP:0000982)2.92249861
67Breast hypoplasia (HP:0003187)2.90721366
68Papilledema (HP:0001085)2.90131305
69Abnormality of the lower motor neuron (HP:0002366)2.88607103
70Furrowed tongue (HP:0000221)2.86911007
71Urinary urgency (HP:0000012)2.84193789
72Amblyopia (HP:0000646)2.82672280
73Abnormal eating behavior (HP:0100738)2.82087374
74Truncal ataxia (HP:0002078)2.71589536
75Scanning speech (HP:0002168)2.70973839
76Pterygium (HP:0001059)2.65602411
77Aplasia cutis congenita (HP:0001057)2.62637972
78Lower limb amyotrophy (HP:0007210)2.61367164
79Abnormal EKG (HP:0003115)2.59349463
80Abnormality of secondary sexual hair (HP:0009888)2.58668203
81Abnormality of the axillary hair (HP:0100134)2.58668203
82Ventricular fibrillation (HP:0001663)2.58405028
83Hypohidrosis (HP:0000966)2.57357673
84Blepharitis (HP:0000498)2.56978459
85Impaired vibratory sensation (HP:0002495)2.52910132
86Mutism (HP:0002300)2.52424437
87Abnormality of the salivary glands (HP:0010286)2.52413540
88Lip pit (HP:0100267)2.51382383
89Hypoplasia of dental enamel (HP:0006297)2.48518311
90Intention tremor (HP:0002080)2.48369560
91Anonychia (HP:0001798)2.45630096
92Bradykinesia (HP:0002067)2.44857809
93Impaired smooth pursuit (HP:0007772)2.44800046
94Spastic gait (HP:0002064)2.44700742
95Hemiplegia (HP:0002301)2.42043049
96Advanced eruption of teeth (HP:0006288)2.41814943
97Incomplete penetrance (HP:0003829)2.40923563
98Bronchomalacia (HP:0002780)2.39024397
99* Increased IgE level (HP:0003212)2.38859705
100Ectropion (HP:0000656)2.38352390
101Cerebral inclusion bodies (HP:0100314)2.35945912
102Prolonged QT interval (HP:0001657)2.35630726
103Neurofibrillary tangles (HP:0002185)2.35342908
104Selective tooth agenesis (HP:0001592)2.34305219
105Concave nail (HP:0001598)2.33256412
106Abnormality of oral frenula (HP:0000190)2.33064789
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.28823531
108Abnormality of placental membranes (HP:0011409)2.27143723
109Amniotic constriction ring (HP:0009775)2.27143723
110Polygenic inheritance (HP:0010982)2.26408211
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25872455
112Bundle branch block (HP:0011710)2.25118778
113Follicular hyperkeratosis (HP:0007502)2.22752736
114Absent hair (HP:0002298)2.20992645
115Epileptiform EEG discharges (HP:0011182)2.20194467
116Depressed nasal tip (HP:0000437)2.19649676
117Distal lower limb amyotrophy (HP:0008944)2.19644513
118Abnormality of ocular smooth pursuit (HP:0000617)2.16856038
119Hemiparesis (HP:0001269)2.16155080
120Status epilepticus (HP:0002133)2.12946193
121Atrioventricular block (HP:0001678)2.12390682
122Hyperventilation (HP:0002883)2.12376483
123Megalencephaly (HP:0001355)2.10703712
124Lower limb asymmetry (HP:0100559)2.09963629
125EEG with generalized epileptiform discharges (HP:0011198)2.09414200
126Truncus arteriosus (HP:0001660)2.09200788
127Recurrent corneal erosions (HP:0000495)2.08952966
128Heart block (HP:0012722)2.08845301
129Parakeratosis (HP:0001036)2.07370547
130Labial hypoplasia (HP:0000066)2.05695521
131Hypercortisolism (HP:0001578)2.05062071
132Carious teeth (HP:0000670)2.04253961
133Laryngomalacia (HP:0001601)2.04122656
134Spinal canal stenosis (HP:0003416)2.03790580
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03394647
136Hypsarrhythmia (HP:0002521)2.02621358
137Obstructive sleep apnea (HP:0002870)2.02348858
138Dry hair (HP:0011359)2.01528018
139Limb dystonia (HP:0002451)2.01526053
140Fetal akinesia sequence (HP:0001989)2.00777734
141Fragile skin (HP:0001030)2.00217091
142Global brain atrophy (HP:0002283)1.99948399
143Oligodontia (HP:0000677)1.99772936
144Lower limb muscle weakness (HP:0007340)1.99275696
145Clonus (HP:0002169)1.97998402
146Insomnia (HP:0100785)1.95975889
147Absent/shortened dynein arms (HP:0200106)1.94321553
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.94321553
149Ventricular tachycardia (HP:0004756)1.94201719
150Onion bulb formation (HP:0003383)1.93992485
151Brittle hair (HP:0002299)1.93841046
152Tetraplegia (HP:0002445)1.93831842
153Hypoplastic female external genitalia (HP:0012815)1.92108805
154Drooling (HP:0002307)1.92016633
155Excessive salivation (HP:0003781)1.92016633
156Abnormality of cochlea (HP:0000375)1.91980934
157Abnormality of binocular vision (HP:0011514)1.91476886
158Diplopia (HP:0000651)1.91476886
159Abnormal atrioventricular conduction (HP:0005150)1.88953370
160Delusions (HP:0000746)1.88715043
161Genetic anticipation (HP:0003743)1.88552983
162Progressive inability to walk (HP:0002505)1.87413528
163Popliteal pterygium (HP:0009756)1.87384475
164Dehydration (HP:0001944)1.86495124
165Enlarged epiphyses (HP:0010580)1.85408179
166Neuronal loss in central nervous system (HP:0002529)1.85133054
167Abnormality of saccadic eye movements (HP:0000570)1.85118902
168Slow-growing hair (HP:0002217)1.85113381
169Abnormality of hair growth rate (HP:0011363)1.85113381
170Deep palmar crease (HP:0006191)1.84407454
171Upper limb amyotrophy (HP:0009129)1.84069625
172Distal upper limb amyotrophy (HP:0007149)1.84069625
173Acanthosis nigricans (HP:0000956)1.83066738
174Absent speech (HP:0001344)1.82832937
175Generalized myoclonic seizures (HP:0002123)1.81806935
176Aplasia involving bones of the extremities (HP:0009825)1.81620420
177Aplasia involving bones of the upper limbs (HP:0009823)1.81620420
178Aplasia of the phalanges of the hand (HP:0009802)1.81620420
179Gait ataxia (HP:0002066)1.80235077
180Birth length less than 3rd percentile (HP:0003561)1.79967000
181Curly hair (HP:0002212)1.79917851
182Termporal pattern (HP:0011008)1.77316842
183Abnormality of the labia (HP:0000058)1.75118338
184Poikiloderma (HP:0001029)1.74988521
185Abnormality of the neuromuscular junction (HP:0003398)1.74637965
186Fatigable weakness (HP:0003473)1.74637965
187* Hyperhidrosis (HP:0000975)1.73583941
188Duplicated collecting system (HP:0000081)1.72440797
189Melanocytic nevus (HP:0000995)1.72070844
190Ulnar claw (HP:0001178)1.71548440
191Abnormality of permanent molar morphology (HP:0011071)1.70866720
192Abnormality of the dental root (HP:0006486)1.70866720
193Taurodontia (HP:0000679)1.70866720
194Conjunctival hamartoma (HP:0100780)1.70436482
195Morphological abnormality of the inner ear (HP:0011390)1.68037626
196Abnormality of the dental pulp (HP:0006479)1.64089063
197Abnormality of the gastric mucosa (HP:0004295)1.63838631
198Focal segmental glomerulosclerosis (HP:0000097)1.63452415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.43331222
2PNCK6.01053775
3NTRK34.79352122
4EPHA24.36727232
5LATS14.16576225
6MST1R3.99605596
7MAP3K93.82504041
8TAOK33.71987340
9PLK43.58922482
10KSR23.08503138
11STK38L2.98133596
12MET2.79956404
13WEE12.57432282
14DAPK22.49615109
15BRSK22.43258165
16MAP3K132.42855531
17PRKD32.36920711
18MAPKAPK52.35760683
19MINK12.35628622
20ARAF2.28272257
21KSR12.27256279
22TSSK62.18125422
23RIPK42.12066636
24CDK122.09646221
25CAMKK11.94347294
26MAPK151.86172452
27ACVR1B1.82699630
28PAK61.79584280
29MAPKAPK31.75217070
30SIK31.70147939
31FES1.67872013
32MAP3K41.67716737
33PTK21.64925288
34PBK1.61471780
35NTRK21.59982815
36TRIB31.58509989
37CDK51.58223097
38NTRK11.58198700
39TGFBR11.56742089
40TNIK1.48329035
41DAPK11.47798747
42MAP3K21.46680057
43MAP2K71.46005465
44RAF11.45886363
45TAOK11.42070458
46SIK21.36140955
47TYRO31.24364806
48MARK31.23358896
49PRPF4B1.21898289
50MARK11.19154030
51STK241.15815063
52CAMKK21.15091451
53WNK41.14612206
54INSRR1.14496138
55PRKCH1.14464619
56PTK2B1.13370919
57PINK11.10120774
58ICK1.09188451
59GRK51.08720453
60BRD41.08337068
61PRKCG1.07299329
62PLK21.06223606
63BMPR21.04308854
64STK391.03788968
65NEK91.03543411
66STK381.02940664
67TLK11.01169598
68RIPK11.00632389
69SGK2230.99429326
70SGK4940.99429326
71ERN10.95079020
72SGK20.93414804
73ALK0.92945068
74MAP2K40.91078589
75CDK180.90910575
76MAP3K10.89714157
77CAMK2B0.89388350
78CAMK10.88954768
79STK30.85446051
80CAMK2A0.84977028
81UHMK10.82446850
82CDK150.82358316
83MAPK130.81346526
84SGK30.79311494
85CDK140.79197907
86SGK10.78117591
87PIM20.77073697
88RPS6KB20.76769140
89CDK190.75888063
90EPHB20.75847605
91IRAK40.75630233
92SIK10.75052442
93MAP3K120.74300908
94CDK11A0.73306978
95MARK20.73094466
96MAP2K10.72193782
97STK110.70463941
98CDC42BPA0.69918482
99PRKG20.69694231
100PDK10.68737444
101LMTK20.67628478
102PDPK10.65999272
103MAPKAPK20.64851414
104NEK10.64521345
105NME20.63591924
106MOS0.62563261
107EPHB10.62288479
108TTK0.58479600
109NME10.56312728
110RET0.55874373
111RPS6KA30.55662497
112PKN10.55225965
113TNK20.54823334
114CHEK20.54635760
115BRAF0.54349776
116DYRK1A0.53810690
117DDR20.53301876
118BRSK10.53133222
119MAP3K70.53120500
120BCR0.52403423
121SMG10.51879974
122CAMK40.51060111
123BMX0.49385644
124CDK70.48854031
125TRPM70.47747904
126NEK60.47714952
127FYN0.46500019
128CDK30.46106682
129MAP3K60.45850214
130PDGFRA0.45072861
131DMPK0.43845647
132PAK30.43621661
133PRKCZ0.40997457
134ABL20.39971475
135AURKA0.39827592
136PRKD20.38545900
137CAMK2G0.38424592
138FLT30.37980528
139FER0.37856830
140PRKCE0.37585758
141RPS6KA20.37218561
142OXSR10.37120767
143BMPR1B0.36063623
144PRKCI0.35305171
145FGR0.34961733
146MAPK100.34884218
147PRKCB0.34790771
148MTOR0.33766023
149MAP3K30.33319870
150MAP2K60.33263441
151DAPK30.33053914
152PRKACG0.33039881
153RPS6KA10.32270376
154CSNK1A10.32031356
155PRKCA0.31537885
156RPS6KA60.30904942
157WNK10.30245500
158TESK10.29608012
159ERBB30.29486884
160PDGFRB0.29246806
161CAMK2D0.29214422
162LATS20.28787099
163PRKACA0.28236325
164PHKG20.27871125
165PHKG10.27871125
166CASK0.26781403
167IRAK10.26301758
168ADRBK20.26120906
169ILK0.25414045
170RPS6KA40.23968840
171ERBB20.23028929
172BUB10.22735034
173RPS6KC10.22541443
174RPS6KL10.22541443
175IRAK30.22248753
176ADRBK10.19578111

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.61319724
2Nicotine addiction_Homo sapiens_hsa050333.36819275
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94196078
4Amphetamine addiction_Homo sapiens_hsa050312.89886215
5Circadian entrainment_Homo sapiens_hsa047132.80402581
6ECM-receptor interaction_Homo sapiens_hsa045122.79118159
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75164296
8Long-term potentiation_Homo sapiens_hsa047202.75025005
9Morphine addiction_Homo sapiens_hsa050322.69482677
10GABAergic synapse_Homo sapiens_hsa047272.65359326
11Sulfur relay system_Homo sapiens_hsa041222.59114795
12Basal cell carcinoma_Homo sapiens_hsa052172.49274071
13Glutamatergic synapse_Homo sapiens_hsa047242.46868713
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44552429
15Hippo signaling pathway_Homo sapiens_hsa043902.42039066
16Cocaine addiction_Homo sapiens_hsa050302.38899960
17Dopaminergic synapse_Homo sapiens_hsa047282.30447243
18Cholinergic synapse_Homo sapiens_hsa047252.11976205
19Salivary secretion_Homo sapiens_hsa049702.10050243
20Linoleic acid metabolism_Homo sapiens_hsa005912.00187918
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87351023
22Phenylalanine metabolism_Homo sapiens_hsa003601.85258546
23Gastric acid secretion_Homo sapiens_hsa049711.83356666
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82291026
25Sphingolipid metabolism_Homo sapiens_hsa006001.80682302
26Renin secretion_Homo sapiens_hsa049241.80251593
27Calcium signaling pathway_Homo sapiens_hsa040201.78693439
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78553452
29p53 signaling pathway_Homo sapiens_hsa041151.78344267
30Insulin secretion_Homo sapiens_hsa049111.76664782
31Oxytocin signaling pathway_Homo sapiens_hsa049211.71687060
32Bladder cancer_Homo sapiens_hsa052191.66624616
33Serotonergic synapse_Homo sapiens_hsa047261.65191448
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64726253
35Fatty acid biosynthesis_Homo sapiens_hsa000611.56508363
36Small cell lung cancer_Homo sapiens_hsa052221.51797978
37Taste transduction_Homo sapiens_hsa047421.50211526
38Long-term depression_Homo sapiens_hsa047301.49568217
39Nitrogen metabolism_Homo sapiens_hsa009101.48283658
40Steroid biosynthesis_Homo sapiens_hsa001001.47343076
41GnRH signaling pathway_Homo sapiens_hsa049121.46601032
42cAMP signaling pathway_Homo sapiens_hsa040241.41959343
43Ether lipid metabolism_Homo sapiens_hsa005651.40766244
44Gap junction_Homo sapiens_hsa045401.37447068
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34374141
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32811945
47Collecting duct acid secretion_Homo sapiens_hsa049661.32241818
48Adherens junction_Homo sapiens_hsa045201.30663789
49Mineral absorption_Homo sapiens_hsa049781.30442620
50Hedgehog signaling pathway_Homo sapiens_hsa043401.25005972
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21894802
52Fanconi anemia pathway_Homo sapiens_hsa034601.20035755
53Glioma_Homo sapiens_hsa052141.14204532
54MicroRNAs in cancer_Homo sapiens_hsa052061.11225525
55Notch signaling pathway_Homo sapiens_hsa043301.09378029
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08162134
57Tyrosine metabolism_Homo sapiens_hsa003501.06670050
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06191876
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03765982
60Proteoglycans in cancer_Homo sapiens_hsa052051.02091888
61Protein digestion and absorption_Homo sapiens_hsa049741.01886468
62Histidine metabolism_Homo sapiens_hsa003401.01161946
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00977822
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00847023
65Estrogen signaling pathway_Homo sapiens_hsa049150.98492018
66Nucleotide excision repair_Homo sapiens_hsa034200.97583603
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97438646
68PPAR signaling pathway_Homo sapiens_hsa033200.97356524
69Melanogenesis_Homo sapiens_hsa049160.96402022
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.96188537
71Amoebiasis_Homo sapiens_hsa051460.95904770
72Type II diabetes mellitus_Homo sapiens_hsa049300.94571826
73Folate biosynthesis_Homo sapiens_hsa007900.93764025
74Focal adhesion_Homo sapiens_hsa045100.89204205
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.87639521
76Melanoma_Homo sapiens_hsa052180.87563775
77ErbB signaling pathway_Homo sapiens_hsa040120.87208206
78Dorso-ventral axis formation_Homo sapiens_hsa043200.87082819
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86120075
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84940103
81Axon guidance_Homo sapiens_hsa043600.84229287
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83852564
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83789630
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82973323
85Butanoate metabolism_Homo sapiens_hsa006500.82193935
86Tight junction_Homo sapiens_hsa045300.81161952
87Vibrio cholerae infection_Homo sapiens_hsa051100.80835188
88Pancreatic secretion_Homo sapiens_hsa049720.79200857
89Phototransduction_Homo sapiens_hsa047440.77153473
90Oocyte meiosis_Homo sapiens_hsa041140.76892869
91Pathways in cancer_Homo sapiens_hsa052000.75908412
92Arachidonic acid metabolism_Homo sapiens_hsa005900.75519378
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.73668090
94Thyroid hormone synthesis_Homo sapiens_hsa049180.73230235
95Dilated cardiomyopathy_Homo sapiens_hsa054140.72633986
96Glycerolipid metabolism_Homo sapiens_hsa005610.72273140
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72048816
98Fatty acid elongation_Homo sapiens_hsa000620.71522254
99Rap1 signaling pathway_Homo sapiens_hsa040150.71025351
100Cardiac muscle contraction_Homo sapiens_hsa042600.70771269
101Cell cycle_Homo sapiens_hsa041100.69952309
102Alcoholism_Homo sapiens_hsa050340.69898275
103VEGF signaling pathway_Homo sapiens_hsa043700.68972048
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67972571
105beta-Alanine metabolism_Homo sapiens_hsa004100.67868219
106Non-small cell lung cancer_Homo sapiens_hsa052230.67255236
107Choline metabolism in cancer_Homo sapiens_hsa052310.65071701
108MAPK signaling pathway_Homo sapiens_hsa040100.64681393
109Type I diabetes mellitus_Homo sapiens_hsa049400.62783743
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.61136716
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59943562
112Glucagon signaling pathway_Homo sapiens_hsa049220.59553812
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58812956
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58642455
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56797731
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56736798
117Chemokine signaling pathway_Homo sapiens_hsa040620.56478747
118Prostate cancer_Homo sapiens_hsa052150.53944091
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53820344
120DNA replication_Homo sapiens_hsa030300.53501770
121Prion diseases_Homo sapiens_hsa050200.53466331
122Ras signaling pathway_Homo sapiens_hsa040140.53430743
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53140196
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50578872
125Bile secretion_Homo sapiens_hsa049760.50073585
126African trypanosomiasis_Homo sapiens_hsa051430.46962352
127Toxoplasmosis_Homo sapiens_hsa051450.46591027
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46547941
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45729050
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.44245466
131Pancreatic cancer_Homo sapiens_hsa052120.42694452
132Arginine biosynthesis_Homo sapiens_hsa002200.42217907
133Vitamin digestion and absorption_Homo sapiens_hsa049770.41730770
134Prolactin signaling pathway_Homo sapiens_hsa049170.41417326
135mTOR signaling pathway_Homo sapiens_hsa041500.39925459
136Endocytosis_Homo sapiens_hsa041440.39543984
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38804197
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37014015
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36981929
140Inositol phosphate metabolism_Homo sapiens_hsa005620.36296691
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32651527
142Endometrial cancer_Homo sapiens_hsa052130.31070181
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30042004
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.29605465
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28868222
146Circadian rhythm_Homo sapiens_hsa047100.28833837
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25795040
148Wnt signaling pathway_Homo sapiens_hsa043100.24477053
149Thyroid cancer_Homo sapiens_hsa052160.23861265
150Platelet activation_Homo sapiens_hsa046110.23389082
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22765311
152Insulin signaling pathway_Homo sapiens_hsa049100.22314886
153Ovarian steroidogenesis_Homo sapiens_hsa049130.22061757

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