ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	9.06492049
2	adhesion of symbiont to host (GO:0044406)	8.63337696
3	peptide cross-linking (GO:0018149)	8.37907529
4	hair follicle morphogenesis (GO:0031069)	8.19085011
5	intermediate filament cytoskeleton organization (GO:0045104)	6.58884171
6	cell wall macromolecule metabolic process (GO:0044036)	6.47076730
7	cell wall macromolecule catabolic process (GO:0016998)	6.47076730
8	intermediate filament-based process (GO:0045103)	6.37879842
9	epidermis development (GO:0008544)	6.06540486
10	citrulline metabolic process (GO:0000052)	5.99692763
11	establishment of skin barrier (GO:0061436)	5.94435688
12	keratinocyte differentiation (GO:0030216)	5.81416439
13	hair cycle process (GO:0022405)	5.32017765
14	molting cycle process (GO:0022404)	5.32017765
15	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.27361528
16	regulation of water loss via skin (GO:0033561)	5.25579145
17	skin morphogenesis (GO:0043589)	5.11128852
18	peptidyl-arginine modification (GO:0018195)	5.01064312
19	hemidesmosome assembly (GO:0031581)	4.78568176
20	epidermal cell differentiation (GO:0009913)	4.54317308
21	tooth mineralization (GO:0034505)	4.00727389
22	molting cycle (GO:0042303)	34.5394931
23	hair cycle (GO:0042633)	34.5394931
24	keratinocyte development (GO:0003334)	3.87080908
25	multicellular organismal water homeostasis (GO:0050891)	3.54458318
26	negative regulation of keratinocyte proliferation (GO:0010839)	3.37110873
27	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.26958414
28	hair follicle development (GO:0001942)	3.19021272
29	positive regulation of hair cycle (GO:0042635)	3.18690767
30	positive regulation of hair follicle development (GO:0051798)	3.18690767
31	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.18195490
32	regulation of keratinocyte differentiation (GO:0045616)	3.14933404
33	regulation of hair follicle development (GO:0051797)	3.00121117
34	bone trabecula formation (GO:0060346)	2.93619247
35	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.90827278
36	water homeostasis (GO:0030104)	2.90003903
37	epithelium development (GO:0060429)	2.88370858
38	fatty acid elongation (GO:0030497)	2.77540491
39	ectoderm development (GO:0007398)	2.76880472
40	gap junction assembly (GO:0016264)	2.75112226
41	atrioventricular valve morphogenesis (GO:0003181)	2.73603431
42	positive regulation of meiotic cell cycle (GO:0051446)	2.70207054
43	negative regulation of protein localization to plasma membrane (GO:1903077)	2.70096339
44	positive regulation of epidermis development (GO:0045684)	2.69217304
45	regulation of hair cycle (GO:0042634)	2.67364442
46	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.64424334
47	regulation of epidermal cell differentiation (GO:0045604)	2.45500957
48	ventricular cardiac muscle cell action potential (GO:0086005)	2.45145959
49	negative regulation of cell fate specification (GO:0009996)	2.40487851
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.40407438
51	regulation of epidermis development (GO:0045682)	2.39825222
52	lymph vessel development (GO:0001945)	2.37430494
53	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.31313540
54	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.25138981
55	skin development (GO:0043588)	2.23012664
56	phosphatidylserine metabolic process (GO:0006658)	2.21810098
57	positive regulation of epidermal cell differentiation (GO:0045606)	2.20074970
58	wound healing, spreading of epidermal cells (GO:0035313)	2.20020864
59	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.11951907
60	myotube differentiation (GO:0014902)	2.11281303
61	regulation of cardioblast differentiation (GO:0051890)	2.11086994
62	cranial suture morphogenesis (GO:0060363)	2.10169362
63	epithelial cell-cell adhesion (GO:0090136)	2.07320538
64	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.06164944
65	positive regulation of monocyte chemotaxis (GO:0090026)	2.05795965
66	outflow tract septum morphogenesis (GO:0003148)	2.05307776
67	regulation of heart rate by cardiac conduction (GO:0086091)	2.05066739
68	aging (GO:0007568)	2.03108148
69	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.02810028
70	intermediate filament organization (GO:0045109)	12.0340568
71	keratinization (GO:0031424)	11.4419833
72	desmosome organization (GO:0002934)	10.2300333
73	virion attachment to host cell (GO:0019062)	10.2260027
74	adhesion of symbiont to host cell (GO:0044650)	10.2260027
75	regulation of ruffle assembly (GO:1900027)	1.97964290
76	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.97952382
77	negative regulation of epidermis development (GO:0045683)	1.94892859
78	cell communication involved in cardiac conduction (GO:0086065)	1.92574596
79	regulation of keratinocyte proliferation (GO:0010837)	1.91807336
80	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.87039383
81	ephrin receptor signaling pathway (GO:0048013)	1.86694880
82	coronary vasculature morphogenesis (GO:0060977)	1.83971281
83	non-canonical Wnt signaling pathway (GO:0035567)	1.83180172
84	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.82099818
85	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.78662478
86	regulation of cardioblast proliferation (GO:0003264)	1.78662478
87	cell-substrate junction assembly (GO:0007044)	1.78393195
88	very long-chain fatty acid metabolic process (GO:0000038)	1.69219734
89	outer ear morphogenesis (GO:0042473)	1.67963663
90	negative regulation of cell fate commitment (GO:0010454)	1.66673320
91	keratinocyte proliferation (GO:0043616)	1.65938287
92	primary alcohol catabolic process (GO:0034310)	1.63898227
93	alditol phosphate metabolic process (GO:0052646)	1.63390236
94	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.62276857
95	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.62276857
96	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.61795329
97	cardiac right ventricle morphogenesis (GO:0003215)	1.61533204
98	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.61495899
99	cardiac conduction (GO:0061337)	1.60715529
100	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.60276244

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.70445081
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.81122989
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.51177012
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.69696051
5	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.16801142
6	* CTCF_20526341_ChIP-Seq_ESCs_Human	2.14551239
7	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.11908544
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.4006700
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.96508998
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.81111260
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.78749302
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.77764459
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.74868886
14	EGR1_19032775_ChIP-ChIP_M12_Human	1.70777868
15	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.69853294
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.67899048
17	CTCF_27219007_Chip-Seq_Bcells_Human	1.62428061
18	ERG_20517297_ChIP-Seq_VCAP_Human	1.58041571
19	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.55629499
20	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.55408131
21	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.54248990
22	LXR_22292898_ChIP-Seq_THP-1_Human	1.52029472
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51120109
24	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.48809855
25	TP63_22573176_ChIP-Seq_HFKS_Human	1.48627465
26	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.47241749
27	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.46990480
28	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.46990480
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.44329810
30	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.41563404
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.41121366
32	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.37519555
33	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36252866
34	BCOR_27268052_Chip-Seq_Bcells_Human	1.35180566
35	ATF3_27146783_Chip-Seq_COLON_Human	1.33874870
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.33259886
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33034149
38	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.32660605
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28531275
40	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.25728261
41	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24177189
42	PHF8_20622854_ChIP-Seq_HELA_Human	1.23989947
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22246610
44	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21078875
45	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19842516
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19200033
47	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.18089681
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.17642827
49	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17117233
50	P68_20966046_ChIP-Seq_HELA_Human	1.16659729
51	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15301517
52	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14547204
53	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14186129
54	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.10901479
55	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.09661964
56	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08675549
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.08471428
58	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.07496022
59	TP63_23658742_ChIP-Seq_EP156T_Human	1.07448862
60	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.07420339
61	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06131256
62	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.05640894
63	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04726320
64	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04562273
65	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.03096817
66	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99027765
67	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98584099
68	SPI1_20517297_ChIP-Seq_HL60_Human	0.95814774
69	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95715759
70	* SMC4_20622854_ChIP-Seq_HELA_Human	0.94829673
71	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.94358773
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94273771
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.94162229
74	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.93208192
75	TP53_18474530_ChIP-ChIP_U2OS_Human	0.92102512
76	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.91898662
77	* E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91345652
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91332531
79	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.90296536
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89711103
81	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.89406305
82	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.89010239
83	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.88119126
84	RXR_22108803_ChIP-Seq_LS180_Human	0.87858948
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.86856032
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84986851
87	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.84566339
88	AR_21572438_ChIP-Seq_LNCaP_Human	0.84511385
89	* SOX2_21211035_ChIP-Seq_LN229_Human	0.83647280
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.83306710
91	SOX2_20726797_ChIP-Seq_SW620_Human	0.82960483
92	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.81756844
93	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.78367341
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77581992
95	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.76926575
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.76287590
97	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.76029247
98	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.75106511
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.74470957
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.74215251

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.61472839
2	MP0002098_abnormal_vibrissa_morphology	7.11938685
3	MP0000647_abnormal_sebaceous_gland	6.45237102
4	MP0002796_impaired_skin_barrier	6.01075543
5	MP0005275_abnormal_skin_tensile	5.25100650
6	MP0010234_abnormal_vibrissa_follicle	5.05937955
7	MP0000383_abnormal_hair_follicle	4.47591341
8	MP0000377_abnormal_hair_follicle	4.07238514
9	MP0010678_abnormal_skin_adnexa	3.97138364
10	MP0003705_abnormal_hypodermis_morpholog	3.79629496
11	MP0005501_abnormal_skin_physiology	3.76660184
12	MP0000427_abnormal_hair_cycle	3.54085110
13	MP0002254_reproductive_system_inflammat	3.02713207
14	MP0001216_abnormal_epidermal_layer	2.68034939
15	MP0004381_abnormal_hair_follicle	2.48924638
16	MP0000367_abnormal_coat/_hair	2.34106864
17	MP0010771_integument_phenotype	2.31550421
18	MP0004947_skin_inflammation	2.29820361
19	MP0002060_abnormal_skin_morphology	2.21060032
20	MP0001243_abnormal_dermal_layer	2.19549963
21	MP0003453_abnormal_keratinocyte_physiol	2.13218888
22	MP0002234_abnormal_pharynx_morphology	2.08591610
23	MP0000467_abnormal_esophagus_morphology	1.68905750
24	MP0009931_abnormal_skin_appearance	1.50219226
25	MP0009053_abnormal_anal_canal	1.47526408
26	MP0000762_abnormal_tongue_morphology	1.47458363
27	MP0003566_abnormal_cell_adhesion	1.43199205
28	MP0005409_darkened_coat_color	1.19985836
29	MP0003941_abnormal_skin_development	1.18255378
30	MP0001191_abnormal_skin_condition	0.99948686
31	MP0004885_abnormal_endolymph	0.93574084
32	MP0004185_abnormal_adipocyte_glucose	0.89971825
33	MP0002095_abnormal_skin_pigmentation	0.83125670
34	MP0004264_abnormal_extraembryonic_tissu	0.82572791
35	MP0001851_eye_inflammation	0.82371095
36	MP0008438_abnormal_cutaneous_collagen	0.79880771
37	MP0001346_abnormal_lacrimal_gland	0.71714675
38	MP0001849_ear_inflammation	0.68413965
39	MP0001340_abnormal_eyelid_morphology	0.66113722
40	MP0003315_abnormal_perineum_morphology	0.65694355
41	MP0010030_abnormal_orbit_morphology	0.62199882
42	MP0002877_abnormal_melanocyte_morpholog	0.61552418
43	MP0001661_extended_life_span	0.61069027
44	MP0000566_synostosis	0.59060020
45	MP0000627_abnormal_mammary_gland	0.56116795
46	MP0003191_abnormal_cellular_cholesterol	0.53906227
47	MP0002282_abnormal_trachea_morphology	0.50219600
48	MP0003755_abnormal_palate_morphology	0.49270425
49	MP0005451_abnormal_body_composition	0.48016027
50	MP0002249_abnormal_larynx_morphology	0.47775007
51	MP0001784_abnormal_fluid_regulation	0.46478353
52	MP0005023_abnormal_wound_healing	0.46430254
53	MP0002970_abnormal_white_adipose	0.45006848
54	MP0000678_abnormal_parathyroid_gland	0.43018261
55	MP0002111_abnormal_tail_morphology	0.40365991
56	MP0005075_abnormal_melanosome_morpholog	0.34688717
57	MP0004272_abnormal_basement_membrane	0.33056933
58	MP0003385_abnormal_body_wall	0.33011498
59	MP0002177_abnormal_outer_ear	0.32301581
60	MP0010352_gastrointestinal_tract_polyps	0.32033157
61	MP0009379_abnormal_foot_pigmentation	0.30666953
62	MP0009840_abnormal_foam_cell	0.29187870
63	MP0000537_abnormal_urethra_morphology	0.28478634
64	MP0003950_abnormal_plasma_membrane	0.25852764
65	MP0003763_abnormal_thymus_physiology	0.25145893
66	MP0002697_abnormal_eye_size	0.24402573
67	MP0005248_abnormal_Harderian_gland	0.23829366
68	MP0000465_gastrointestinal_hemorrhage	0.23662795
69	MP0003329_amyloid_beta_deposits	0.22127171
70	MP0003300_gastrointestinal_ulcer	0.21183605
71	MP0004019_abnormal_vitamin_homeostasis	0.20319814
72	MP0001879_abnormal_lymphatic_vessel	0.19861232
73	MP0006054_spinal_hemorrhage	0.19662437
74	MP0000432_abnormal_head_morphology	0.18917504
75	MP0004742_abnormal_vestibular_system	0.17620630
76	MP0003935_abnormal_craniofacial_develop	0.16081268
77	MP0005666_abnormal_adipose_tissue	0.15822930
78	MP0005375_adipose_tissue_phenotype	0.15228265
79	MP0000516_abnormal_urinary_system	0.15145905
80	MP0005367_renal/urinary_system_phenotyp	0.15145905
81	MP0003448_altered_tumor_morphology	0.15039100
82	MP0000751_myopathy	0.14368276
83	MP0004858_abnormal_nervous_system	0.13489607
84	MP0003011_delayed_dark_adaptation	0.13479016
85	MP0003638_abnormal_response/metabolism_	0.13086368
86	MP0000462_abnormal_digestive_system	0.12998426
87	MP0000733_abnormal_muscle_development	0.12346589
88	MP0002233_abnormal_nose_morphology	0.12266544
89	MP0005076_abnormal_cell_differentiation	0.11386191
90	MP0001958_emphysema	0.11005376
91	MP0000604_amyloidosis	0.10865120
92	MP0003045_fibrosis	0.09779564
93	MP0002006_tumorigenesis	0.09450908
94	MP0005508_abnormal_skeleton_morphology	0.08808093
95	MP0005193_abnormal_anterior_eye	0.08793691
96	MP0003075_altered_response_to	0.08743227
97	MP0002166_altered_tumor_susceptibility	0.08265951
98	MP0009384_cardiac_valve_regurgitation	0.07720559
99	MP0008569_lethality_at_weaning	0.07419373
100	MP0000013_abnormal_adipose_tissue	0.07200239

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Brittle hair (HP:0002299)	9.94630943
2	Pili torti (HP:0003777)	9.18110367
3	Nail dystrophy (HP:0008404)	7.17454305
4	Abnormality of nail color (HP:0100643)	6.16712550
5	Abnormal hair laboratory examination (HP:0003328)	5.79126586
6	Fragile nails (HP:0001808)	5.56951031
7	Fine hair (HP:0002213)	5.12024459
8	Onycholysis (HP:0001806)	5.02644771
9	Increased IgE level (HP:0003212)	4.96520792
10	Alopecia of scalp (HP:0002293)	4.90500726
11	Palmoplantar hyperkeratosis (HP:0000972)	4.86874730
12	Palmar hyperkeratosis (HP:0010765)	4.57993094
13	Plantar hyperkeratosis (HP:0007556)	4.43413953
14	Thick nail (HP:0001805)	4.41604211
15	Right ventricular cardiomyopathy (HP:0011663)	4.36262722
16	Follicular hyperkeratosis (HP:0007502)	4.29616329
17	Erythema (HP:0010783)	3.67017866
18	Sparse eyelashes (HP:0000653)	3.58866004
19	Oral leukoplakia (HP:0002745)	3.32919783
20	Amelogenesis imperfecta (HP:0000705)	3.16197461
21	Abnormality of the frontal sinuses (HP:0002687)	3.16024035
22	Milia (HP:0001056)	3.15561682
23	Erythroderma (HP:0001019)	3.01816628
24	Parakeratosis (HP:0001036)	2.88277522
25	Curly hair (HP:0002212)	2.79026711
26	Ridged nail (HP:0001807)	2.61759125
27	Congenital, generalized hypertrichosis (HP:0004540)	2.61371803
28	Intention tremor (HP:0002080)	2.59646222
29	Congenital ichthyosiform erythroderma (HP:0007431)	2.54861761
30	Neck muscle weakness (HP:0000467)	2.50599546
31	Aplasia cutis congenita (HP:0001057)	2.49766698
32	Abnormal blistering of the skin (HP:0008066)	2.43884488
33	Natal tooth (HP:0000695)	2.43506196
34	Advanced eruption of teeth (HP:0006288)	2.39855668
35	Torticollis (HP:0000473)	2.34804962
36	Dry hair (HP:0011359)	2.29212531
37	Ventricular tachycardia (HP:0004756)	2.09813750
38	Hypohidrosis (HP:0000966)	2.09475642
39	Corneal erosion (HP:0200020)	2.09298338
40	Palmoplantar keratoderma (HP:0000982)	2.03140751
41	Hypotrichosis (HP:0001006)	14.5892379
42	Woolly hair (HP:0002224)	11.1976413
43	Abnormality of hair growth rate (HP:0011363)	10.8128938
44	Slow-growing hair (HP:0002217)	10.8128938
45	Craniofacial dystonia (HP:0012179)	1.97736778
46	Pruritus (HP:0000989)	1.94055883
47	Difficulty walking (HP:0002355)	1.91764101
48	Abnormality of the pupil (HP:0000615)	1.85848406
49	Ventricular fibrillation (HP:0001663)	1.83564579
50	Focal dystonia (HP:0004373)	1.80607424
51	Abnormality of the dental root (HP:0006486)	1.80071678
52	Taurodontia (HP:0000679)	1.80071678
53	Abnormality of permanent molar morphology (HP:0011071)	1.80071678
54	Abnormality of molar morphology (HP:0011070)	1.78471094
55	Abnormality of molar (HP:0011077)	1.78471094
56	Abnormality of the parietal bone (HP:0002696)	1.77483763
57	Concave nail (HP:0001598)	1.77201193
58	Abnormality of dental color (HP:0011073)	1.76932195
59	Conjunctival hamartoma (HP:0100780)	1.76324725
60	Widely patent fontanelles and sutures (HP:0004492)	1.70168658
61	Unilateral renal agenesis (HP:0000122)	1.66011999
62	Hyporeflexia of lower limbs (HP:0002600)	1.65974854
63	Absent eyelashes (HP:0000561)	1.64497312
64	Recurrent corneal erosions (HP:0000495)	1.62564073
65	Abnormality of the neuromuscular junction (HP:0003398)	1.58742160
66	Fatigable weakness (HP:0003473)	1.58742160
67	Abnormality of the aortic arch (HP:0012303)	1.58149482
68	Abnormality of the dental pulp (HP:0006479)	1.57454123
69	Blepharitis (HP:0000498)	1.57052504
70	Sudden death (HP:0001699)	1.53925867
71	Abnormality of placental membranes (HP:0011409)	1.48329560
72	Amniotic constriction ring (HP:0009775)	1.48329560
73	Acanthosis nigricans (HP:0000956)	1.48313029
74	Hypergammaglobulinemia (HP:0010702)	1.45470597
75	Lip pit (HP:0100267)	1.42672137
76	Round ear (HP:0100830)	1.41198960
77	Carious teeth (HP:0000670)	1.40511047
78	Distal lower limb muscle weakness (HP:0009053)	1.40358459
79	Gangrene (HP:0100758)	1.38381274
80	Heterogeneous (HP:0001425)	1.38304901
81	Craniofacial hyperostosis (HP:0004493)	1.37501769
82	Keratoconjunctivitis sicca (HP:0001097)	1.37311567
83	Type 1 muscle fiber predominance (HP:0003803)	1.36695552
84	Ectropion (HP:0000656)	1.36103983
85	Anonychia (HP:0001798)	1.35008458
86	Achilles tendon contracture (HP:0001771)	1.33816335
87	Autoamputation (HP:0001218)	1.29531999
88	Increased connective tissue (HP:0009025)	1.26728420
89	Abnormality of the fingernails (HP:0001231)	1.26316076
90	Atrophic scars (HP:0001075)	1.26104089
91	Abnormality of the Achilles tendon (HP:0005109)	1.25549297
92	Laryngomalacia (HP:0001601)	1.20848020
93	Keratoconjunctivitis (HP:0001096)	1.20571982
94	Neonatal onset (HP:0003623)	1.20131317
95	Widely spaced teeth (HP:0000687)	1.18772614
96	Selective tooth agenesis (HP:0001592)	1.18644901
97	Sparse scalp hair (HP:0002209)	1.17869515
98	Abnormality of the gastric mucosa (HP:0004295)	1.16357448
99	Lack of skin elasticity (HP:0100679)	1.15848742
100	Variable expressivity (HP:0003828)	1.14735058

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.30319751
2	EPHA2	4.23987244
3	MAPKAPK3	3.98529589
4	ERN1	3.80113892
5	MAP3K6	3.69488995
6	EPHB2	3.22249662
7	TAOK1	3.09194574
8	MAP3K3	2.78859248
9	TRIB3	2.69486225
10	LATS1	2.43895339
11	MAP3K2	2.31909388
12	PIK3CG	2.11326036
13	MAP3K11	2.07638066
14	TTN	2.06290816
15	RPS6KB2	1.93353975
16	EEF2K	1.86513627
17	EPHB1	1.73629397
18	LATS2	1.61905576
19	MAP2K6	1.55555384
20	BCR	1.39256204
21	FGFR4	1.30599941
22	MAP3K1	1.30338166
23	NME1	1.27586892
24	BLK	1.26478072
25	FGFR2	1.23839722
26	FGFR1	1.23379644
27	RIPK1	1.22997070
28	BMX	1.22988302
29	MAP2K3	1.21447281
30	KSR2	1.14248393
31	CDK6	1.13552312
32	PKN2	1.13347889
33	MST1R	1.11974340
34	MAPKAPK2	1.08799344
35	OBSCN	1.07278338
36	PDGFRA	1.05930662
37	SIK1	1.03249172
38	FGFR3	1.02929066
39	MAP3K7	1.02875509
40	PTK6	0.96868090
41	LRRK2	0.95329444
42	PBK	0.89389833
43	PTK2	0.85467139
44	MAP3K9	0.84044961
45	MAP2K4	0.83200279
46	RPS6KA4	0.78415400
47	STK38	0.75245229
48	MAP2K1	0.74321228
49	STK38L	0.71949793
50	DYRK1B	0.71932088
51	PRKD1	0.70295673
52	PIM2	0.67809375
53	CDK19	0.67799690
54	PAK4	0.66968073
55	PAK3	0.66166481
56	MET	0.65899733
57	DDR2	0.65641696
58	MAP3K10	0.63544200
59	TESK1	0.60788143
60	EPHA3	0.57647204
61	NTRK2	0.55311369
62	TRPM7	0.54946271
63	PRKCI	0.54156651
64	JAK1	0.53853199
65	PRKCH	0.53477622
66	PAK6	0.52707173
67	ERBB4	0.51191262
68	MAP3K5	0.50656317
69	PAK2	0.50539187
70	TYRO3	0.50120691
71	RET	0.49615592
72	MAPK12	0.46781592
73	ERBB2	0.46544990
74	TYK2	0.45908336
75	RPS6KA1	0.44837858
76	TGFBR1	0.43140359
77	ALK	0.41462188
78	GSK3A	0.40603317
79	NEK1	0.39088145
80	PHKG1	0.38446048
81	PHKG2	0.38446048
82	MAP2K2	0.38154413
83	CSNK1E	0.37164458
84	CLK1	0.34977638
85	JAK2	0.34106711
86	FYN	0.30730622
87	GRK6	0.30294317
88	MST4	0.29648142
89	TGFBR2	0.28633852
90	MAP3K8	0.28116176
91	LIMK1	0.24852721
92	SRC	0.24593033
93	CSNK1A1	0.24540372
94	STK11	0.24330187
95	HCK	0.22544080
96	ILK	0.22214662
97	PRKACG	0.22114548
98	PRKACA	0.21757593
99	ICK	0.21688445
100	ROCK2	0.21039827

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.67584427
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.62563539
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.09695556
4	Fatty acid elongation_Homo sapiens_hsa00062	2.99531187
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.45094076
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.26043636
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.93045233
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.86638941
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.79448282
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.75144117
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.66097713
12	Axon guidance_Homo sapiens_hsa04360	1.58848070
13	Melanogenesis_Homo sapiens_hsa04916	1.58725338
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.38765461
15	Caffeine metabolism_Homo sapiens_hsa00232	1.38112642
16	Histidine metabolism_Homo sapiens_hsa00340	1.37781980
17	Glioma_Homo sapiens_hsa05214	1.34445868
18	Bladder cancer_Homo sapiens_hsa05219	1.29747290
19	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.28905455
20	Proteoglycans in cancer_Homo sapiens_hsa05205	1.28278249
21	Thyroid cancer_Homo sapiens_hsa05216	1.25475622
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.24559126
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.23627714
24	GnRH signaling pathway_Homo sapiens_hsa04912	1.22762144
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.22615257
26	Tight junction_Homo sapiens_hsa04530	1.16366589
27	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14222706
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.11754697
29	Pancreatic secretion_Homo sapiens_hsa04972	1.08993650
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.08737465
31	Mineral absorption_Homo sapiens_hsa04978	1.05791762
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04579967
33	ECM-receptor interaction_Homo sapiens_hsa04512	1.04275317
34	Adherens junction_Homo sapiens_hsa04520	1.01880529
35	Long-term potentiation_Homo sapiens_hsa04720	0.97200514
36	Nitrogen metabolism_Homo sapiens_hsa00910	0.95134264
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.91503683
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.90651435
39	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.90424509
40	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87443942
41	Endometrial cancer_Homo sapiens_hsa05213	0.86953623
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.85828677
43	Pertussis_Homo sapiens_hsa05133	0.84507267
44	Amoebiasis_Homo sapiens_hsa05146	0.83398326
45	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.81876524
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81784568
47	Ras signaling pathway_Homo sapiens_hsa04014	0.81205419
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81131819
49	Long-term depression_Homo sapiens_hsa04730	0.79437304
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.79216534
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.73685216
52	Gastric acid secretion_Homo sapiens_hsa04971	0.72615807
53	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.72326028
54	Phototransduction_Homo sapiens_hsa04744	0.72261136
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.70478392
56	Renin secretion_Homo sapiens_hsa04924	0.67806378
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.66665359
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65531630
59	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64412852
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.64381622
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.63362021
62	Insulin resistance_Homo sapiens_hsa04931	0.62929710
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61973365
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61223947
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.56670462
66	Hepatitis C_Homo sapiens_hsa05160	0.56129924
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56077748
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.55045368
69	Focal adhesion_Homo sapiens_hsa04510	0.54941254
70	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.54462421
71	Salivary secretion_Homo sapiens_hsa04970	0.54053749
72	Gap junction_Homo sapiens_hsa04540	0.52490119
73	Salmonella infection_Homo sapiens_hsa05132	0.51461082
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51043538
75	Platelet activation_Homo sapiens_hsa04611	0.49711739
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.49315013
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.48183148
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.47802898
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.46240738
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45390053
81	Fatty acid degradation_Homo sapiens_hsa00071	0.45271824
82	Notch signaling pathway_Homo sapiens_hsa04330	0.43508361
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43108133
84	Butanoate metabolism_Homo sapiens_hsa00650	0.43096290
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.42238858
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41926329
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41631395
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41582812
89	Tuberculosis_Homo sapiens_hsa05152	0.39482755
90	Toxoplasmosis_Homo sapiens_hsa05145	0.39287146
91	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.39163287
92	Insulin signaling pathway_Homo sapiens_hsa04910	0.38439462
93	Prion diseases_Homo sapiens_hsa05020	0.38221484
94	Olfactory transduction_Homo sapiens_hsa04740	0.38126671
95	Prolactin signaling pathway_Homo sapiens_hsa04917	0.37740193
96	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34185241
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.33968165
98	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.33733225
99	Melanoma_Homo sapiens_hsa05218	0.32887889
100	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.31357353

KRTAP1-3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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