KRTAP1-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)8.90052791
2adhesion of symbiont to host (GO:0044406)8.71231336
3peptide cross-linking (GO:0018149)8.67533332
4hair follicle morphogenesis (GO:0031069)8.12920637
5establishment of skin barrier (GO:0061436)7.07330721
6intermediate filament cytoskeleton organization (GO:0045104)6.68917532
7intermediate filament-based process (GO:0045103)6.47508255
8regulation of water loss via skin (GO:0033561)6.18031556
9epidermis development (GO:0008544)6.10444632
10keratinocyte differentiation (GO:0030216)6.09136232
11cell wall macromolecule metabolic process (GO:0044036)6.05092974
12cell wall macromolecule catabolic process (GO:0016998)6.05092974
13citrulline metabolic process (GO:0000052)5.86095881
14bundle of His cell to Purkinje myocyte communication (GO:0086069)5.44727601
15molting cycle process (GO:0022404)5.25180183
16hair cycle process (GO:0022405)5.25180183
17skin morphogenesis (GO:0043589)5.24745509
18hemidesmosome assembly (GO:0031581)4.92882260
19peptidyl-arginine modification (GO:0018195)4.92201783
20epidermal cell differentiation (GO:0009913)4.73545678
21multicellular organismal water homeostasis (GO:0050891)4.12810947
22hair cycle (GO:0042633)34.3750975
23molting cycle (GO:0042303)34.3750975
24tooth mineralization (GO:0034505)3.95269234
25keratinocyte development (GO:0003334)3.79832080
26water homeostasis (GO:0030104)3.38087673
27negative regulation of keratinocyte proliferation (GO:0010839)3.31385169
28phosphatidylinositol acyl-chain remodeling (GO:0036149)3.27910483
29negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.23217704
30hair follicle development (GO:0001942)3.11398531
31regulation of keratinocyte differentiation (GO:0045616)3.09145447
32positive regulation of hair cycle (GO:0042635)3.07614823
33positive regulation of hair follicle development (GO:0051798)3.07614823
34phosphatidylserine acyl-chain remodeling (GO:0036150)3.00613994
35regulation of hair follicle development (GO:0051797)2.91878573
36epithelium development (GO:0060429)2.88706621
37fatty acid elongation (GO:0030497)2.85492990
38ectoderm development (GO:0007398)2.84375614
39bone trabecula formation (GO:0060346)2.78745423
40atrioventricular valve morphogenesis (GO:0003181)2.77564630
41phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.68529334
42positive regulation of epidermis development (GO:0045684)2.67342150
43gap junction assembly (GO:0016264)2.66428076
44negative regulation of protein localization to plasma membrane (GO:1903077)2.64263291
45regulation of hair cycle (GO:0042634)2.62709321
46positive regulation of meiotic cell cycle (GO:0051446)2.55748145
47ventricular cardiac muscle cell action potential (GO:0086005)2.47052169
48negative regulation of cell fate specification (GO:0009996)2.46586317
49regulation of epidermal cell differentiation (GO:0045604)2.41670775
50lymph vessel development (GO:0001945)2.41268500
51regulation of epidermis development (GO:0045682)2.37337196
52skin development (GO:0043588)2.34853548
53regulation of mesenchymal cell apoptotic process (GO:2001053)2.28666070
54phosphatidylserine metabolic process (GO:0006658)2.26273898
55epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.22527738
56positive regulation of epidermal cell differentiation (GO:0045606)2.21982531
57cell surface receptor signaling pathway involved in heart development (GO:0061311)2.18129118
58phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.17789168
59regulation of cardioblast differentiation (GO:0051890)2.14006416
60epithelial cell-cell adhesion (GO:0090136)2.09910571
61regulation of heart rate by cardiac conduction (GO:0086091)2.08172102
62myotube differentiation (GO:0014902)2.07946710
63regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.07565388
64wound healing, spreading of epidermal cells (GO:0035313)2.07037525
65cytoskeletal anchoring at plasma membrane (GO:0007016)2.06258893
66positive regulation of monocyte chemotaxis (GO:0090026)2.05909105
67aging (GO:0007568)2.02439061
68keratinization (GO:0031424)12.4882908
69intermediate filament organization (GO:0045109)12.0936332
70desmosome organization (GO:0002934)10.4251414
71adhesion of symbiont to host cell (GO:0044650)10.3399470
72virion attachment to host cell (GO:0019062)10.3399470
73outflow tract septum morphogenesis (GO:0003148)1.98244580
74regulation of ruffle assembly (GO:1900027)1.96659201
75cranial suture morphogenesis (GO:0060363)1.94960840
76cell communication involved in cardiac conduction (GO:0086065)1.93361146
77planar cell polarity pathway involved in neural tube closure (GO:0090179)1.92332909
78phosphatidylcholine acyl-chain remodeling (GO:0036151)1.91895896
79outer ear morphogenesis (GO:0042473)1.91022845
80keratinocyte proliferation (GO:0043616)1.90749547
81coronary vasculature morphogenesis (GO:0060977)1.89799670
82negative regulation of epidermis development (GO:0045683)1.88658101
83regulation of cardioblast proliferation (GO:0003264)1.87933587
84regulation of secondary heart field cardioblast proliferation (GO:0003266)1.87933587
85regulation of keratinocyte proliferation (GO:0010837)1.87166367
86ephrin receptor signaling pathway (GO:0048013)1.82127594
87cell-substrate junction assembly (GO:0007044)1.82010357
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.79412582
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.79412582
90non-canonical Wnt signaling pathway (GO:0035567)1.77537260
91regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.76036147
92very long-chain fatty acid metabolic process (GO:0000038)1.74210043
93primary alcohol catabolic process (GO:0034310)1.73646400
94negative regulation of cell fate commitment (GO:0010454)1.72082606
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.66741342
96alditol phosphate metabolic process (GO:0052646)1.65503733
97cardiac conduction (GO:0061337)1.65443203
98establishment of planar polarity (GO:0001736)1.58543029
99establishment of tissue polarity (GO:0007164)1.58543029
100long-chain fatty-acyl-CoA metabolic process (GO:0035336)1.56718052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.37428871
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.68495589
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.60792831
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72693419
5CTCF_20526341_ChIP-Seq_ESCs_Human2.33849366
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.13561860
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.10692874
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.6856140
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.96748459
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.87327148
11E2F1_20622854_ChIP-Seq_HELA_Human1.84048139
12TAF2_19829295_ChIP-Seq_ESCs_Human1.80082523
13SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76066844
14NANOG_20526341_ChIP-Seq_ESCs_Human1.73044791
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.71744200
16EGR1_19032775_ChIP-ChIP_M12_Human1.70552681
17CSB_26484114_Chip-Seq_FIBROBLAST_Human1.67826223
18ERG_20517297_ChIP-Seq_VCAP_Human1.63212523
19CTCF_27219007_Chip-Seq_Bcells_Human1.59861759
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55758262
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53400271
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53400271
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.53246616
24TP63_22573176_ChIP-Seq_HFKS_Human1.52064562
25P53_21459846_ChIP-Seq_SAOS-2_Human1.51527638
26BCL6_27268052_Chip-Seq_Bcells_Human1.49725174
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.49355592
28RACK7_27058665_Chip-Seq_MCF-7_Human1.49343955
29LXR_22292898_ChIP-Seq_THP-1_Human1.48727951
30MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.47608552
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46123641
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.45896240
33BCOR_27268052_Chip-Seq_Bcells_Human1.41829719
34ATF3_27146783_Chip-Seq_COLON_Human1.38129909
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35902876
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.35581370
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33840271
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29997323
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.28036532
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26559006
41SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23463281
42PHF8_20622854_ChIP-Seq_HELA_Human1.23416101
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21415766
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19584277
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.18338788
46P68_20966046_ChIP-Seq_HELA_Human1.17705883
47CEBPB_22108803_ChIP-Seq_LS180_Human1.16964491
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.16380991
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15871786
50AHR_22903824_ChIP-Seq_MCF-7_Human1.15074715
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14627369
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.12226017
53RAC3_21632823_ChIP-Seq_H3396_Human1.11546969
54TP63_23658742_ChIP-Seq_EP156T_Human1.11112444
55SMC4_20622854_ChIP-Seq_HELA_Human1.10612400
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09081311
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09072789
58ZNF263_19887448_ChIP-Seq_K562_Human1.08084376
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07815736
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07599109
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06604513
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.05848271
63E2F1_17053090_ChIP-ChIP_MCF-7_Human1.05793223
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.05366353
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05218482
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04958634
67GATA4_25053715_ChIP-Seq_YYC3_Human1.03760872
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.03634792
69SPI1_20517297_ChIP-Seq_HL60_Human1.01140152
70KLF5_25053715_ChIP-Seq_YYC3_Human0.99784534
71GATA6_21074721_ChIP-Seq_CACO-2_Human0.97262618
72RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97083558
73SOX2_21211035_ChIP-Seq_LN229_Human0.96671593
74ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96064021
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95402401
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94683156
77FOXH1_21741376_ChIP-Seq_ESCs_Human0.93541674
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93299367
79ERG_21242973_ChIP-ChIP_JURKAT_Human0.90688755
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90008644
81RUNX1_27514584_Chip-Seq_MCF-7_Human0.88902760
82RXR_22108803_ChIP-Seq_LS180_Human0.88457864
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88047094
84TP53_18474530_ChIP-ChIP_U2OS_Human0.87063089
85SOX2_20726797_ChIP-Seq_SW620_Human0.86774131
86RING1B_27294783_Chip-Seq_ESCs_Mouse0.85470984
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81392717
88AR_21572438_ChIP-Seq_LNCaP_Human0.80959662
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80311273
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80135918
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.80059339
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.77680920
93TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76281767
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.75719023
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74904227
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74501574
97ZFP281_18757296_ChIP-ChIP_E14_Mouse0.74019295
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73456305
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73226912
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72714659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.56678797
2MP0002098_abnormal_vibrissa_morphology6.91459055
3MP0000647_abnormal_sebaceous_gland6.30925402
4MP0002796_impaired_skin_barrier6.25063765
5MP0005275_abnormal_skin_tensile5.47372836
6MP0010234_abnormal_vibrissa_follicle5.02320663
7MP0000383_abnormal_hair_follicle4.37858314
8MP0000377_abnormal_hair_follicle4.00075983
9MP0005501_abnormal_skin_physiology3.91904436
10MP0010678_abnormal_skin_adnexa3.88808380
11MP0003705_abnormal_hypodermis_morpholog3.82101062
12MP0000427_abnormal_hair_cycle3.44813034
13MP0002254_reproductive_system_inflammat2.92572885
14MP0001216_abnormal_epidermal_layer2.73158158
15MP0004381_abnormal_hair_follicle2.57866507
16MP0004947_skin_inflammation2.42176084
17MP0010771_integument_phenotype2.38503915
18MP0000367_abnormal_coat/_hair2.30559383
19MP0002060_abnormal_skin_morphology2.27451932
20MP0001243_abnormal_dermal_layer2.17114534
21MP0002234_abnormal_pharynx_morphology2.16918221
22MP0003453_abnormal_keratinocyte_physiol2.12730719
23MP0000467_abnormal_esophagus_morphology1.68913096
24MP0009931_abnormal_skin_appearance1.54718442
25MP0000762_abnormal_tongue_morphology1.45578688
26MP0003566_abnormal_cell_adhesion1.45297292
27MP0009053_abnormal_anal_canal1.40915437
28MP0005409_darkened_coat_color1.27645107
29MP0003941_abnormal_skin_development1.27235348
30MP0001191_abnormal_skin_condition1.03605784
31MP0002095_abnormal_skin_pigmentation0.98820739
32MP0001851_eye_inflammation0.86876067
33MP0004185_abnormal_adipocyte_glucose0.85553995
34MP0004885_abnormal_endolymph0.85080917
35MP0008438_abnormal_cutaneous_collagen0.84375489
36MP0004264_abnormal_extraembryonic_tissu0.78126304
37MP0002877_abnormal_melanocyte_morpholog0.69862492
38MP0001849_ear_inflammation0.67403821
39MP0001346_abnormal_lacrimal_gland0.64483454
40MP0001340_abnormal_eyelid_morphology0.64282371
41MP0003315_abnormal_perineum_morphology0.63531524
42MP0003191_abnormal_cellular_cholesterol0.63246042
43MP0010030_abnormal_orbit_morphology0.62601420
44MP0005451_abnormal_body_composition0.61322078
45MP0009379_abnormal_foot_pigmentation0.57361257
46MP0001661_extended_life_span0.55295942
47MP0000627_abnormal_mammary_gland0.55148101
48MP0000566_synostosis0.53787369
49MP0001784_abnormal_fluid_regulation0.50051846
50MP0005023_abnormal_wound_healing0.47744281
51MP0002282_abnormal_trachea_morphology0.47734962
52MP0003755_abnormal_palate_morphology0.47424775
53MP0002249_abnormal_larynx_morphology0.44714052
54MP0002970_abnormal_white_adipose0.43140992
55MP0000678_abnormal_parathyroid_gland0.42966240
56MP0002177_abnormal_outer_ear0.42255902
57MP0002111_abnormal_tail_morphology0.38936508
58MP0005075_abnormal_melanosome_morpholog0.37734832
59MP0003763_abnormal_thymus_physiology0.32000454
60MP0000465_gastrointestinal_hemorrhage0.31538805
61MP0001188_hyperpigmentation0.31286418
62MP0004272_abnormal_basement_membrane0.29555880
63MP0003385_abnormal_body_wall0.29088825
64MP0010352_gastrointestinal_tract_polyps0.28482101
65MP0009840_abnormal_foam_cell0.27224876
66MP0005248_abnormal_Harderian_gland0.25305514
67MP0003011_delayed_dark_adaptation0.24390798
68MP0003950_abnormal_plasma_membrane0.24327986
69MP0001879_abnormal_lymphatic_vessel0.24214406
70MP0002697_abnormal_eye_size0.24171806
71MP0000537_abnormal_urethra_morphology0.22039877
72MP0003329_amyloid_beta_deposits0.20803428
73MP0004019_abnormal_vitamin_homeostasis0.19929895
74MP0003300_gastrointestinal_ulcer0.18868851
75MP0006054_spinal_hemorrhage0.18169471
76MP0000432_abnormal_head_morphology0.17705410
77MP0004742_abnormal_vestibular_system0.16949615
78MP0003448_altered_tumor_morphology0.14815104
79MP0003935_abnormal_craniofacial_develop0.14631732
80MP0010368_abnormal_lymphatic_system0.14140490
81MP0005666_abnormal_adipose_tissue0.13777863
82MP0002233_abnormal_nose_morphology0.13428265
83MP0005375_adipose_tissue_phenotype0.12967825
84MP0003638_abnormal_response/metabolism_0.12939672
85MP0001958_emphysema0.11450601
86MP0004858_abnormal_nervous_system0.11215604
87MP0000516_abnormal_urinary_system0.10710092
88MP0005367_renal/urinary_system_phenotyp0.10710092
89MP0000733_abnormal_muscle_development0.10008998
90MP0005193_abnormal_anterior_eye0.09726905
91MP0003045_fibrosis0.08893203
92MP0000604_amyloidosis0.08860963
93MP0002006_tumorigenesis0.08670057
94MP0005076_abnormal_cell_differentiation0.08392466
95MP0008569_lethality_at_weaning0.08326044
96MP0003075_altered_response_to0.07794832
97MP0000751_myopathy0.07692051
98MP0002166_altered_tumor_susceptibility0.07687502
99MP0000462_abnormal_digestive_system0.07509924
100MP0005508_abnormal_skeleton_morphology0.06864777

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.72272237
2Pili torti (HP:0003777)9.19926773
3Nail dystrophy (HP:0008404)7.07122884
4Abnormality of nail color (HP:0100643)6.44776261
5Abnormal hair laboratory examination (HP:0003328)5.81510247
6Increased IgE level (HP:0003212)5.59036300
7Fragile nails (HP:0001808)5.44213373
8Onycholysis (HP:0001806)5.18895505
9Palmoplantar hyperkeratosis (HP:0000972)5.17367802
10Fine hair (HP:0002213)5.02471064
11Alopecia of scalp (HP:0002293)4.92057597
12Palmar hyperkeratosis (HP:0010765)4.87127376
13Plantar hyperkeratosis (HP:0007556)4.68004676
14Thick nail (HP:0001805)4.55458934
15Follicular hyperkeratosis (HP:0007502)4.42906446
16Right ventricular cardiomyopathy (HP:0011663)4.38825596
17Erythema (HP:0010783)3.99355271
18Sparse eyelashes (HP:0000653)3.62998978
19Erythroderma (HP:0001019)3.35416961
20Oral leukoplakia (HP:0002745)3.31157186
21Milia (HP:0001056)3.23058978
22Amelogenesis imperfecta (HP:0000705)3.03738144
23Abnormality of the frontal sinuses (HP:0002687)2.99950538
24Parakeratosis (HP:0001036)2.81372250
25Congenital ichthyosiform erythroderma (HP:0007431)2.79049255
26Curly hair (HP:0002212)2.74356184
27Congenital, generalized hypertrichosis (HP:0004540)2.64476421
28Abnormal blistering of the skin (HP:0008066)2.63835376
29Ridged nail (HP:0001807)2.63223714
30Intention tremor (HP:0002080)2.56341618
31Natal tooth (HP:0000695)2.54080962
32Advanced eruption of teeth (HP:0006288)2.47053845
33Conjunctival hamartoma (HP:0100780)2.45487325
34Dry hair (HP:0011359)2.38606957
35Neck muscle weakness (HP:0000467)2.38376142
36Torticollis (HP:0000473)2.34666498
37Aplasia cutis congenita (HP:0001057)2.33735322
38Corneal erosion (HP:0200020)2.18419889
39Hypohidrosis (HP:0000966)2.13550959
40Palmoplantar keratoderma (HP:0000982)2.12762651
41Ventricular tachycardia (HP:0004756)2.10530697
42Pruritus (HP:0000989)2.02390012
43Hypotrichosis (HP:0001006)14.5082912
44Woolly hair (HP:0002224)11.1311973
45Abnormality of hair growth rate (HP:0011363)10.5796610
46Slow-growing hair (HP:0002217)10.5796610
47Craniofacial dystonia (HP:0012179)1.97536807
48Ventricular fibrillation (HP:0001663)1.86509732
49Abnormality of the pupil (HP:0000615)1.84733424
50Difficulty walking (HP:0002355)1.84047214
51Focal dystonia (HP:0004373)1.80159686
52Unilateral renal agenesis (HP:0000122)1.76191322
53Abnormality of the parietal bone (HP:0002696)1.75277193
54Gangrene (HP:0100758)1.71549065
55Abnormality of the neuromuscular junction (HP:0003398)1.70807254
56Fatigable weakness (HP:0003473)1.70807254
57Abnormality of permanent molar morphology (HP:0011071)1.70131237
58Abnormality of the dental root (HP:0006486)1.70131237
59Taurodontia (HP:0000679)1.70131237
60Abnormality of molar (HP:0011077)1.69012300
61Abnormality of molar morphology (HP:0011070)1.69012300
62Hypergammaglobulinemia (HP:0010702)1.67121636
63Concave nail (HP:0001598)1.64765536
64Abnormality of dental color (HP:0011073)1.64276770
65Abnormality of the aortic arch (HP:0012303)1.62356613
66Blepharitis (HP:0000498)1.60437539
67Absent eyelashes (HP:0000561)1.58821196
68Widely patent fontanelles and sutures (HP:0004492)1.57252891
69Hamartoma of the eye (HP:0010568)1.55540842
70Recurrent corneal erosions (HP:0000495)1.52837439
71Hyporeflexia of lower limbs (HP:0002600)1.52672950
72Ectropion (HP:0000656)1.49654430
73Abnormality of the dental pulp (HP:0006479)1.48466110
74Sudden death (HP:0001699)1.47264087
75Acanthosis nigricans (HP:0000956)1.45738591
76Abnormality of placental membranes (HP:0011409)1.40913622
77Amniotic constriction ring (HP:0009775)1.40913622
78Carious teeth (HP:0000670)1.40241274
79Anonychia (HP:0001798)1.39366112
80Lip pit (HP:0100267)1.36720758
81Heterogeneous (HP:0001425)1.34741742
82Keratoconjunctivitis sicca (HP:0001097)1.34499829
83Atrophic scars (HP:0001075)1.31954684
84Laryngomalacia (HP:0001601)1.28739718
85Achilles tendon contracture (HP:0001771)1.28676978
86Distal lower limb muscle weakness (HP:0009053)1.27728910
87Abnormality of the fingernails (HP:0001231)1.27663008
88Craniofacial hyperostosis (HP:0004493)1.26670923
89Type 1 muscle fiber predominance (HP:0003803)1.26518644
90Increased connective tissue (HP:0009025)1.25132379
91Autoamputation (HP:0001218)1.24067516
92Lack of skin elasticity (HP:0100679)1.22188886
93Selective tooth agenesis (HP:0001592)1.22052941
94Sparse scalp hair (HP:0002209)1.21298411
95Abnormality of the Achilles tendon (HP:0005109)1.20350975
96Neonatal onset (HP:0003623)1.20284293
97Round ear (HP:0100830)1.19759512
98Hyperhidrosis (HP:0000975)1.18719910
99Eczematoid dermatitis (HP:0000976)1.17945888
100Keratoconjunctivitis (HP:0001096)1.17846629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.35930137
2MAPKAPK34.26545265
3EPHA24.04495111
4ERN13.84408957
5MAP3K63.80229541
6TAOK13.09587833
7EPHB23.03508254
8MAP3K32.83226316
9TRIB32.54083897
10RPS6KB22.33549429
11MAP3K22.31521786
12EEF2K2.31144671
13LATS12.17088347
14MAP3K112.08971874
15PIK3CG1.86652209
16TTN1.75824009
17MAP2K61.71603620
18EPHB11.70979670
19FGFR11.62261390
20BCR1.40694179
21LATS21.40584337
22FGFR41.36448459
23NME11.35081028
24MAP2K31.29894209
25MAP3K11.29496465
26MST1R1.27083649
27RIPK11.22492508
28FGFR21.20616128
29PDGFRA1.17425330
30BMX1.15874619
31MAPKAPK21.15299917
32PKN21.08940036
33KSR21.08425302
34MAP3K91.07375097
35CDK61.06492376
36BLK1.04788160
37FGFR31.01045428
38SIK10.98637492
39PTK60.93990003
40LRRK20.92709493
41MAP3K70.92109900
42PIM20.86992951
43CDK190.82154226
44RPS6KA40.79820598
45MAP2K40.79086875
46OBSCN0.77957965
47PTK20.77537874
48PBK0.75359385
49PAK40.73751277
50MET0.72922195
51MAP2K10.71672561
52TRPM70.69505615
53MAP3K100.69152853
54DYRK1B0.67631196
55TGFBR10.66039696
56PRKD10.65714855
57STK380.62430115
58PRKCH0.58794537
59NTRK20.57956914
60JAK10.56706418
61DDR20.56665543
62PAK20.56166754
63TYRO30.55821811
64PAK30.55649120
65TIE10.54119123
66STK38L0.53988775
67EPHA30.53540124
68PRKCI0.52335243
69RET0.49299102
70TYK20.49282424
71RPS6KA10.49174224
72ERBB20.48892352
73TESK10.47605754
74MAP3K50.46127835
75MAPK120.46003962
76MAPKAPK50.42311860
77ALK0.40192630
78ERBB40.39072990
79GSK3A0.38635894
80MST40.38357579
81TGFBR20.37952648
82PAK60.35584216
83CLK10.34822580
84FYN0.33372392
85CSNK1E0.33260948
86MATK0.31990587
87ICK0.31743621
88JAK20.31571027
89MAP3K80.30723695
90ILK0.27791530
91MAP2K20.27375163
92GRK60.27126000
93MAP4K10.25861528
94PDGFRB0.25340112
95SCYL20.24737011
96HCK0.24243174
97ERBB30.24103629
98CSNK1A10.23596679
99SRC0.23385322
100STK110.21172837

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.91662914
2Linoleic acid metabolism_Homo sapiens_hsa005914.86650202
3Fat digestion and absorption_Homo sapiens_hsa049753.12958065
4Fatty acid elongation_Homo sapiens_hsa000623.08163794
5Ether lipid metabolism_Homo sapiens_hsa005652.55348534
6Basal cell carcinoma_Homo sapiens_hsa052172.13775712
7Arachidonic acid metabolism_Homo sapiens_hsa005901.93550441
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89566711
9Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82335410
10Phenylalanine metabolism_Homo sapiens_hsa003601.81575892
11VEGF signaling pathway_Homo sapiens_hsa043701.70079095
12Melanogenesis_Homo sapiens_hsa049161.55595884
13Axon guidance_Homo sapiens_hsa043601.51255856
14Caffeine metabolism_Homo sapiens_hsa002321.48594360
15Glioma_Homo sapiens_hsa052141.36223313
16Histidine metabolism_Homo sapiens_hsa003401.32893616
17Acute myeloid leukemia_Homo sapiens_hsa052211.31755726
18Hedgehog signaling pathway_Homo sapiens_hsa043401.28813158
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.28760889
20Proteoglycans in cancer_Homo sapiens_hsa052051.27315704
21GnRH signaling pathway_Homo sapiens_hsa049121.26464328
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21773469
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20964085
24Bladder cancer_Homo sapiens_hsa052191.20264666
25Thyroid cancer_Homo sapiens_hsa052161.17598134
26Steroid biosynthesis_Homo sapiens_hsa001001.17327261
27Hippo signaling pathway_Homo sapiens_hsa043901.16882269
28ECM-receptor interaction_Homo sapiens_hsa045121.14957403
29Dorso-ventral axis formation_Homo sapiens_hsa043201.14915165
30Tight junction_Homo sapiens_hsa045301.09829425
31Pancreatic secretion_Homo sapiens_hsa049721.05797544
32PPAR signaling pathway_Homo sapiens_hsa033201.02788894
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98293047
34Adherens junction_Homo sapiens_hsa045200.96391422
35Mineral absorption_Homo sapiens_hsa049780.95536795
36Pertussis_Homo sapiens_hsa051330.94518430
37Long-term potentiation_Homo sapiens_hsa047200.93394460
38Nitrogen metabolism_Homo sapiens_hsa009100.89709670
39Glycerophospholipid metabolism_Homo sapiens_hsa005640.88117401
40Tyrosine metabolism_Homo sapiens_hsa003500.87762371
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86760243
42Ras signaling pathway_Homo sapiens_hsa040140.84842306
43Amoebiasis_Homo sapiens_hsa051460.84239365
44Non-small cell lung cancer_Homo sapiens_hsa052230.84078630
45Leukocyte transendothelial migration_Homo sapiens_hsa046700.83987328
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83085794
47Estrogen signaling pathway_Homo sapiens_hsa049150.82145080
48Long-term depression_Homo sapiens_hsa047300.80776855
49Phototransduction_Homo sapiens_hsa047440.80329790
50Staphylococcus aureus infection_Homo sapiens_hsa051500.79288643
51Endometrial cancer_Homo sapiens_hsa052130.79059452
52beta-Alanine metabolism_Homo sapiens_hsa004100.77513474
53Gastric acid secretion_Homo sapiens_hsa049710.72847340
54Wnt signaling pathway_Homo sapiens_hsa043100.70400714
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68878075
56Renin secretion_Homo sapiens_hsa049240.68608277
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65982920
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.64434775
59Protein digestion and absorption_Homo sapiens_hsa049740.63498565
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61651132
61Platelet activation_Homo sapiens_hsa046110.61474709
62Fatty acid metabolism_Homo sapiens_hsa012120.61239706
63MicroRNAs in cancer_Homo sapiens_hsa052060.60412643
64Insulin resistance_Homo sapiens_hsa049310.60341407
65Hepatitis C_Homo sapiens_hsa051600.58587160
66Rap1 signaling pathway_Homo sapiens_hsa040150.57239724
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.56178100
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55474059
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.53342282
70Focal adhesion_Homo sapiens_hsa045100.52871548
71Salivary secretion_Homo sapiens_hsa049700.52831178
72Salmonella infection_Homo sapiens_hsa051320.52027364
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51544927
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49480277
75Chemical carcinogenesis_Homo sapiens_hsa052040.48644409
76Oxytocin signaling pathway_Homo sapiens_hsa049210.48571164
77Gap junction_Homo sapiens_hsa045400.48283866
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47468083
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46983074
80ErbB signaling pathway_Homo sapiens_hsa040120.45195021
81Notch signaling pathway_Homo sapiens_hsa043300.44285375
82Renal cell carcinoma_Homo sapiens_hsa052110.44177186
83Toxoplasmosis_Homo sapiens_hsa051450.43697611
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.43014035
85Fatty acid degradation_Homo sapiens_hsa000710.42623378
86Tuberculosis_Homo sapiens_hsa051520.42603353
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41797076
88TGF-beta signaling pathway_Homo sapiens_hsa043500.41613458
89Olfactory transduction_Homo sapiens_hsa047400.40685947
90Prolactin signaling pathway_Homo sapiens_hsa049170.40089597
91Chronic myeloid leukemia_Homo sapiens_hsa052200.39493684
92Sphingolipid metabolism_Homo sapiens_hsa006000.37217951
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36010079
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35559022
95Insulin signaling pathway_Homo sapiens_hsa049100.34577601
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34219510
97p53 signaling pathway_Homo sapiens_hsa041150.34195469
98Butanoate metabolism_Homo sapiens_hsa006500.31569558
99Prion diseases_Homo sapiens_hsa050200.31160613
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30520273

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