KRTAP1-5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)8.74788387
2peptide cross-linking (GO:0018149)8.55738944
3adhesion of symbiont to host (GO:0044406)8.45910686
4hair follicle morphogenesis (GO:0031069)8.30612242
5intermediate filament cytoskeleton organization (GO:0045104)6.82868379
6intermediate filament-based process (GO:0045103)6.60902720
7epidermis development (GO:0008544)6.21587823
8establishment of skin barrier (GO:0061436)6.01153679
9keratinocyte differentiation (GO:0030216)5.85764547
10cell wall macromolecule catabolic process (GO:0016998)5.84359358
11cell wall macromolecule metabolic process (GO:0044036)5.84359358
12citrulline metabolic process (GO:0000052)5.77430854
13type B pancreatic cell proliferation (GO:0044342)5.66715513
14collagen fibril organization (GO:0030199)5.61715714
15protein heterotrimerization (GO:0070208)5.35599553
16regulation of water loss via skin (GO:0033561)5.33364533
17hair cycle process (GO:0022405)5.32467405
18molting cycle process (GO:0022404)5.32467405
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.12013679
20hemidesmosome assembly (GO:0031581)5.04728891
21skin morphogenesis (GO:0043589)4.80408629
22peptidyl-arginine modification (GO:0018195)4.80361571
23mesenchymal-epithelial cell signaling (GO:0060638)4.67147084
24chondrocyte proliferation (GO:0035988)4.59081900
25epidermal cell differentiation (GO:0009913)4.55190544
26extracellular matrix assembly (GO:0085029)4.36028480
27sequestering of extracellular ligand from receptor (GO:0035581)4.16324109
28cellular response to vitamin (GO:0071295)4.13776702
29cell migration involved in heart development (GO:0060973)4.11235585
30endocardial cushion development (GO:0003197)4.08069777
31endodermal cell differentiation (GO:0035987)4.04948712
32hair cycle (GO:0042633)34.8608409
33molting cycle (GO:0042303)34.8608409
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.91710677
35keratinocyte development (GO:0003334)3.82560029
36positive regulation of fibroblast migration (GO:0010763)3.82354003
37tooth mineralization (GO:0034505)3.77709165
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.73800884
39multicellular organismal water homeostasis (GO:0050891)3.58274279
40negative regulation of smooth muscle cell migration (GO:0014912)3.56064295
41positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54611683
42cellular response to vitamin D (GO:0071305)3.53301654
43regulation of integrin-mediated signaling pathway (GO:2001044)3.52034384
44negative regulation of keratinocyte proliferation (GO:0010839)3.51797969
45protein retention in ER lumen (GO:0006621)3.43089630
46phosphatidylinositol acyl-chain remodeling (GO:0036149)3.40289962
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.39724113
48kidney mesenchyme development (GO:0072074)3.38051313
49regulation of keratinocyte differentiation (GO:0045616)3.34711903
50cell adhesion mediated by integrin (GO:0033627)3.33792113
51regulation of plasminogen activation (GO:0010755)3.30782906
52negative regulation of axon extension involved in axon guidance (GO:0048843)3.30442820
53cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.29659183
54negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.29355437
55cellular response to interferon-alpha (GO:0035457)3.27185134
56extracellular fibril organization (GO:0043206)3.26135996
57negative regulation of nitric-oxide synthase activity (GO:0051001)3.22845953
58cell migration involved in sprouting angiogenesis (GO:0002042)3.22752505
59negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.21714233
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.18378793
61negative regulation of fatty acid transport (GO:2000192)3.16259076
62positive regulation of hair cycle (GO:0042635)3.15536142
63positive regulation of hair follicle development (GO:0051798)3.15536142
64hair follicle development (GO:0001942)3.12991178
65phosphatidylserine acyl-chain remodeling (GO:0036150)3.11313627
66substrate-dependent cell migration (GO:0006929)3.09943019
67heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.06898911
68collagen metabolic process (GO:0032963)3.06237677
69blood vessel maturation (GO:0001955)3.05921983
70positive regulation of endothelial cell apoptotic process (GO:2000353)3.03878390
71extracellular regulation of signal transduction (GO:1900115)3.01417111
72extracellular negative regulation of signal transduction (GO:1900116)3.01417111
73water homeostasis (GO:0030104)2.96316128
74negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.95777911
75epithelium development (GO:0060429)2.94849592
76regulation of hair follicle development (GO:0051797)2.93579253
77apoptotic cell clearance (GO:0043277)2.93226654
78barbed-end actin filament capping (GO:0051016)2.93051672
79negative regulation of stem cell proliferation (GO:2000647)2.92428288
80fibril organization (GO:0097435)2.90932052
81metanephric mesenchyme development (GO:0072075)2.90383732
82hypotonic response (GO:0006971)2.89447192
83collagen catabolic process (GO:0030574)2.87372788
84negative regulation of osteoblast proliferation (GO:0033689)2.86605109
85regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.86133730
86phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.85118468
87bone trabecula formation (GO:0060346)2.83937727
88stress fiber assembly (GO:0043149)2.83806791
89hyaluronan catabolic process (GO:0030214)2.82357640
90regulation of extracellular matrix disassembly (GO:0010715)2.81694102
91gap junction assembly (GO:0016264)2.81509605
92ectoderm development (GO:0007398)2.80844019
93multicellular organismal macromolecule metabolic process (GO:0044259)2.79639804
94smooth muscle tissue development (GO:0048745)2.78437990
95substrate adhesion-dependent cell spreading (GO:0034446)2.76231389
96negative regulation of BMP signaling pathway (GO:0030514)2.74647793
97positive regulation of epidermis development (GO:0045684)2.73628865
98negative regulation of axon guidance (GO:1902668)2.73441540
99actin filament depolymerization (GO:0030042)2.73390615
100positive regulation of extracellular matrix organization (GO:1903055)2.71297759
101extracellular matrix organization (GO:0030198)2.71058385
102extracellular structure organization (GO:0043062)2.70088587
103positive regulation of meiotic cell cycle (GO:0051446)2.68094589
104atrioventricular valve morphogenesis (GO:0003181)2.67966409
105vascular endothelial growth factor signaling pathway (GO:0038084)2.67021760
106negative regulation of protein localization to plasma membrane (GO:1903077)2.65334801
107multicellular organismal metabolic process (GO:0044236)2.64771324
108regulation of hair cycle (GO:0042634)2.63956012
109extracellular matrix disassembly (GO:0022617)2.63740296
110response to magnesium ion (GO:0032026)2.63667498
111dermatan sulfate biosynthetic process (GO:0030208)2.61469127
112positive regulation of protein autophosphorylation (GO:0031954)2.61350423
113regulation of epidermal cell differentiation (GO:0045604)2.60175090
114multicellular organismal catabolic process (GO:0044243)2.59968814
115glomerular basement membrane development (GO:0032836)2.59520174
116negative regulation of leukocyte chemotaxis (GO:0002689)2.58997624
117fatty acid elongation (GO:0030497)2.58978234
118regulation of osteoblast proliferation (GO:0033688)2.58402790
119protein localization to cell surface (GO:0034394)2.58154611
120dermatan sulfate metabolic process (GO:0030205)2.56862895
121negative regulation of embryonic development (GO:0045992)2.55475947
122positive regulation of axon extension (GO:0045773)2.54738091
123regulation of epidermis development (GO:0045682)2.49478624
124ventricular cardiac muscle cell action potential (GO:0086005)2.39375264
125wound healing, spreading of epidermal cells (GO:0035313)2.33931542
126phosphatidylserine metabolic process (GO:0006658)2.33013236
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.32771602
128positive regulation of epidermal cell differentiation (GO:0045606)2.27307191
129phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.26326017
130positive regulation of monocyte chemotaxis (GO:0090026)2.25420512
131negative regulation of cell fate specification (GO:0009996)2.24429682
132skin development (GO:0043588)2.22695640
133cell surface receptor signaling pathway involved in heart development (GO:0061311)2.20992829
134lymph vessel development (GO:0001945)2.16403685
135regulation of mesenchymal cell apoptotic process (GO:2001053)2.14252823
136cranial suture morphogenesis (GO:0060363)2.10685233
137epithelial cell-cell adhesion (GO:0090136)2.05854685
138regulation of ruffle assembly (GO:1900027)2.05623321
139aging (GO:0007568)2.05442256
140regulation of cardioblast differentiation (GO:0051890)2.03116492
141phosphatidylcholine acyl-chain remodeling (GO:0036151)2.00222239
142intermediate filament organization (GO:0045109)12.2841463
143keratinization (GO:0031424)12.0195609
144desmosome organization (GO:0002934)10.1541943
145adhesion of symbiont to host cell (GO:0044650)10.0257800
146virion attachment to host cell (GO:0019062)10.0257800
147regulation of keratinocyte proliferation (GO:0010837)1.96471243
148regulation of heart rate by cardiac conduction (GO:0086091)1.96146304
149outflow tract septum morphogenesis (GO:0003148)1.94963107
150negative regulation of epidermis development (GO:0045683)1.94271955
151cytoskeletal anchoring at plasma membrane (GO:0007016)1.93603165
152myotube differentiation (GO:0014902)1.90834509
153cell-substrate junction assembly (GO:0007044)1.89057206
154planar cell polarity pathway involved in neural tube closure (GO:0090179)1.88250696
155cell communication involved in cardiac conduction (GO:0086065)1.84807703
156ephrin receptor signaling pathway (GO:0048013)1.81536887
157regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.80826421
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.73179058
159non-canonical Wnt signaling pathway (GO:0035567)1.72863734
160alditol phosphate metabolic process (GO:0052646)1.70950043
161wound healing, spreading of cells (GO:0044319)1.70566008
162primary alcohol catabolic process (GO:0034310)1.70517983
163antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.68003496
164antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.68003496
165regulation of secondary heart field cardioblast proliferation (GO:0003266)1.64914136
166regulation of cardioblast proliferation (GO:0003264)1.64914136
167coronary vasculature morphogenesis (GO:0060977)1.62363608
168regulation of monocyte chemotaxis (GO:0090025)1.61262701
169regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.61028578
170very long-chain fatty acid metabolic process (GO:0000038)1.60890239
171regulation of transforming growth factor beta2 production (GO:0032909)1.60377016
172cardiac right ventricle morphogenesis (GO:0003215)1.58817368
173establishment of planar polarity (GO:0001736)1.58650337
174establishment of tissue polarity (GO:0007164)1.58650337
175keratinocyte proliferation (GO:0043616)1.57129004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.04334979
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.90180478
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.65650815
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.59216652
5* BRD4_25478319_ChIP-Seq_HGPS_Human3.04233786
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.82062128
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.67193757
8CTCF_20526341_ChIP-Seq_ESCs_Human2.35697911
9CJUN_26792858_Chip-Seq_BT549_Human2.33231614
10CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.28416594
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.17355871
12BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.13640608
13NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.07799783
14NRF2_20460467_ChIP-Seq_MEFs_Mouse2.07799783
15NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.07795695
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07712343
17TP63_17297297_ChIP-ChIP_HaCaT_Human12.8831463
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88998993
19E2F1_20622854_ChIP-Seq_HELA_Human1.83835125
20TAF2_19829295_ChIP-Seq_ESCs_Human1.82186658
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.81905022
22VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.76596662
23TP53_16413492_ChIP-PET_HCT116_Human1.74694213
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.73870231
25P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.73239909
26CSB_26484114_Chip-Seq_FIBROBLAST_Human1.72285906
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70044182
28EGR1_19032775_ChIP-ChIP_M12_Human1.68767937
29NANOG_20526341_ChIP-Seq_ESCs_Human1.68372957
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67333390
31ERG_20517297_ChIP-Seq_VCAP_Human1.65584241
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64581907
33CLOCK_20551151_ChIP-Seq_293T_Human1.63149223
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60538334
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60538334
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59483633
37P53_21459846_ChIP-Seq_SAOS-2_Human1.58299826
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.57888962
39CTCF_27219007_Chip-Seq_Bcells_Human1.56181437
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.52958662
41RACK7_27058665_Chip-Seq_MCF-7_Human1.51188527
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50147313
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49427528
44TP63_22573176_ChIP-Seq_HFKS_Human1.49126998
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48021619
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47537743
47BCL6_27268052_Chip-Seq_Bcells_Human1.46684238
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45442903
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.45212910
50* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.45155545
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.44692757
52LXR_22292898_ChIP-Seq_THP-1_Human1.43953498
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43578356
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42286155
55BCOR_27268052_Chip-Seq_Bcells_Human1.39844251
56ATF3_27146783_Chip-Seq_COLON_Human1.39348463
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37806576
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35014888
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34641285
60* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.31222992
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.30787871
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29937207
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29937207
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.27562502
65TP53_22127205_ChIP-Seq_IMR90_Human1.27116901
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25959062
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25624364
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.24619374
69SA1_22415368_ChIP-Seq_MEFs_Mouse1.24356765
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.24070830
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.23998474
72AHR_22903824_ChIP-Seq_MCF-7_Human1.23303098
73PHF8_20622854_ChIP-Seq_HELA_Human1.22623508
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22235539
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20286035
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19356766
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.18522967
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18468662
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18410330
80P68_20966046_ChIP-Seq_HELA_Human1.17805746
81CEBPB_22108803_ChIP-Seq_LS180_Human1.16271860
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.14907348
83GATA3_24758297_ChIP-Seq_MCF-7_Human1.14595027
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14124649
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14065196
86E2F1_17053090_ChIP-ChIP_MCF-7_Human1.13815830
87TP63_23658742_ChIP-Seq_EP156T_Human1.12524707
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11837805
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11584342
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11289067
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10235380
92RAC3_21632823_ChIP-Seq_H3396_Human1.09659179
93SMC4_20622854_ChIP-Seq_HELA_Human1.09091407
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09071821
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08694755
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08097168
97TP53_23651856_ChIP-Seq_MEFs_Mouse1.07359669
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06912136
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.06586814
100TP53_18474530_ChIP-ChIP_U2OS_Human1.04148578
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03797836
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03383632
103GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01396958
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.00909254
105TBX20_22080862_ChIP-Seq_HEART_Mouse1.00909254
106SOX2_21211035_ChIP-Seq_LN229_Human0.99857245
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99852622
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99798287
109SA1_27219007_Chip-Seq_ERYTHROID_Human0.99739808
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99026445
111KLF5_25053715_ChIP-Seq_YYC3_Human0.99003134
112SPI1_20517297_ChIP-Seq_HL60_Human0.97879755
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97833195
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95723506
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94843318
116* GATA4_25053715_ChIP-Seq_YYC3_Human0.93370985
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93198129
118FOXH1_21741376_ChIP-Seq_ESCs_Human0.92567526
119GATA6_21074721_ChIP-Seq_CACO-2_Human0.91607237
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91308784
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91113113
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90017675
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.89976755
124RXR_22108803_ChIP-Seq_LS180_Human0.89532183
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89321295
126AR_21572438_ChIP-Seq_LNCaP_Human0.87916562
127SOX2_20726797_ChIP-Seq_SW620_Human0.87676720
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86501183
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85806409
130ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85555350
131GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85373163
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84646719
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.84575494
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.84231876
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83520963
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83272374
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.83133714
138* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82321506
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78594995
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78425459
141ZNF263_19887448_ChIP-Seq_K562_Human0.78423244
142RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77663508
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76860543
144ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76558883
145JARID2_20064375_ChIP-Seq_MESCs_Mouse0.76424434
146HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76406391
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76252392
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75804642
149RNF2_27304074_Chip-Seq_ESCs_Mouse0.75473802
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75112715
151EZH2_27294783_Chip-Seq_ESCs_Mouse0.74030644
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.73703271
153ZFP281_18757296_ChIP-ChIP_E14_Mouse0.73591268
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.73068685
155FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73068685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.63653231
2MP0002098_abnormal_vibrissa_morphology7.12056421
3MP0000647_abnormal_sebaceous_gland6.33801361
4MP0002796_impaired_skin_barrier6.03309705
5MP0005275_abnormal_skin_tensile5.15969248
6MP0010234_abnormal_vibrissa_follicle5.07455863
7MP0005503_abnormal_tendon_morphology4.55875811
8MP0000383_abnormal_hair_follicle4.52257083
9MP0000377_abnormal_hair_follicle4.03421176
10MP0010678_abnormal_skin_adnexa4.00747351
11MP0005501_abnormal_skin_physiology3.77503395
12MP0003279_aneurysm3.74890356
13MP0003705_abnormal_hypodermis_morpholog3.72876427
14MP0000427_abnormal_hair_cycle3.40546923
15MP0002254_reproductive_system_inflammat2.99850165
16MP0001542_abnormal_bone_strength2.87014316
17MP0001216_abnormal_epidermal_layer2.70703821
18MP0004381_abnormal_hair_follicle2.54371303
19MP0005257_abnormal_intraocular_pressure2.39495564
20MP0000367_abnormal_coat/_hair2.35977998
21MP0010771_integument_phenotype2.33751537
22MP0005623_abnormal_meninges_morphology2.33720097
23MP0004947_skin_inflammation2.31888506
24MP0002060_abnormal_skin_morphology2.23564476
25MP0003453_abnormal_keratinocyte_physiol2.22178149
26MP0001243_abnormal_dermal_layer2.14636607
27MP0002234_abnormal_pharynx_morphology2.04622954
28MP0000467_abnormal_esophagus_morphology1.84241856
29MP0010368_abnormal_lymphatic_system1.82888803
30MP0009780_abnormal_chondrocyte_physiolo1.79515340
31MP0002295_abnormal_pulmonary_circulatio1.69780811
32MP0000767_abnormal_smooth_muscle1.68944275
33MP0009053_abnormal_anal_canal1.55819415
34MP0000762_abnormal_tongue_morphology1.53458964
35MP0009931_abnormal_skin_appearance1.52123138
36MP0003091_abnormal_cell_migration1.49886398
37MP0003566_abnormal_cell_adhesion1.49583445
38MP0001299_abnormal_eye_distance/1.47645039
39MP0009250_abnormal_appendicular_skeleto1.42306471
40MP0005409_darkened_coat_color1.35448270
41MP0001348_abnormal_lacrimal_gland1.33208025
42MP0010386_abnormal_urinary_bladder1.30437062
43MP0003941_abnormal_skin_development1.29178620
44MP0002108_abnormal_muscle_morphology1.26804072
45MP0002896_abnormal_bone_mineralization1.16998152
46MP0000534_abnormal_ureter_morphology1.15546889
47MP0005595_abnormal_vascular_smooth1.09828298
48MP0000013_abnormal_adipose_tissue1.04264780
49MP0001191_abnormal_skin_condition1.01707040
50MP0000751_myopathy1.01008513
51MP0005390_skeleton_phenotype0.99292140
52MP0003942_abnormal_urinary_system0.98764061
53MP0004185_abnormal_adipocyte_glucose0.91945058
54MP0004885_abnormal_endolymph0.91322642
55MP0004264_abnormal_extraembryonic_tissu0.89139351
56MP0001851_eye_inflammation0.78856822
57MP0008438_abnormal_cutaneous_collagen0.78652476
58MP0002115_abnormal_skeleton_extremities0.78586632
59MP0000538_abnormal_urinary_bladder0.77033959
60MP0004134_abnormal_chest_morphology0.76591552
61MP0000163_abnormal_cartilage_morphology0.75848207
62MP0000749_muscle_degeneration0.75526932
63MP0002095_abnormal_skin_pigmentation0.75383601
64MP0000759_abnormal_skeletal_muscle0.72665698
65MP0003315_abnormal_perineum_morphology0.69565252
66MP0003283_abnormal_digestive_organ0.68826013
67MP0001849_ear_inflammation0.68517632
68MP0001346_abnormal_lacrimal_gland0.66587767
69MP0001340_abnormal_eyelid_morphology0.64334608
70MP0003191_abnormal_cellular_cholesterol0.62533027
71MP0002113_abnormal_skeleton_development0.60363795
72MP0010030_abnormal_orbit_morphology0.60220197
73MP0002877_abnormal_melanocyte_morpholog0.59810839
74MP0000003_abnormal_adipose_tissue0.59398468
75MP0005164_abnormal_response_to0.59351529
76MP0002128_abnormal_blood_circulation0.58996041
77MP0005451_abnormal_body_composition0.57708971
78MP0000627_abnormal_mammary_gland0.56788211
79MP0000566_synostosis0.56112588
80MP0000049_abnormal_middle_ear0.54272171
81MP0002282_abnormal_trachea_morphology0.53851752
82MP0001661_extended_life_span0.53386686
83MP0005197_abnormal_uvea_morphology0.53174627
84MP0002133_abnormal_respiratory_system0.52928619
85MP0005388_respiratory_system_phenotype0.52928619
86MP0003795_abnormal_bone_structure0.52597314
87MP0005023_abnormal_wound_healing0.52444202
88MP0005171_absent_coat_pigmentation0.51585452
89MP0003755_abnormal_palate_morphology0.50082868
90MP0001533_abnormal_skeleton_physiology0.47089538
91MP0005165_increased_susceptibility_to0.45912042
92MP0001784_abnormal_fluid_regulation0.45713581
93MP0002168_other_aberrant_phenotype0.45381421
94MP0002970_abnormal_white_adipose0.44688834
95MP0002109_abnormal_limb_morphology0.43720059
96MP0001614_abnormal_blood_vessel0.40820379
97MP0010352_gastrointestinal_tract_polyps0.40751537
98MP0004272_abnormal_basement_membrane0.40294630
99MP0002111_abnormal_tail_morphology0.39729429
100MP0002249_abnormal_larynx_morphology0.37803805
101MP0000537_abnormal_urethra_morphology0.36863963
102MP0000678_abnormal_parathyroid_gland0.33863708
103MP0003385_abnormal_body_wall0.32248173
104MP0005075_abnormal_melanosome_morpholog0.30904483
105MP0009840_abnormal_foam_cell0.30523645
106MP0002177_abnormal_outer_ear0.29131955
107MP0002697_abnormal_eye_size0.26352172
108MP0003950_abnormal_plasma_membrane0.25188108
109MP0003329_amyloid_beta_deposits0.24143922
110MP0003763_abnormal_thymus_physiology0.23753177
111MP0000465_gastrointestinal_hemorrhage0.22821904
112MP0003300_gastrointestinal_ulcer0.21371019
113MP0005248_abnormal_Harderian_gland0.20529892
114MP0000516_abnormal_urinary_system0.19643373
115MP0005367_renal/urinary_system_phenotyp0.19643373
116MP0006054_spinal_hemorrhage0.19557116
117MP0000432_abnormal_head_morphology0.17747394
118MP0001879_abnormal_lymphatic_vessel0.17716443
119MP0009379_abnormal_foot_pigmentation0.16940880
120MP0004019_abnormal_vitamin_homeostasis0.16891623
121MP0005666_abnormal_adipose_tissue0.16229461
122MP0003448_altered_tumor_morphology0.16162182
123MP0004742_abnormal_vestibular_system0.14820932
124MP0003935_abnormal_craniofacial_develop0.13570673
125MP0003638_abnormal_response/metabolism_0.13329256
126MP0009384_cardiac_valve_regurgitation0.12707363
127MP0005375_adipose_tissue_phenotype0.12654491
128MP0000604_amyloidosis0.12039744
129MP0003075_altered_response_to0.11555083
130MP0001958_emphysema0.11334920
131MP0005193_abnormal_anterior_eye0.11304284
132MP0002233_abnormal_nose_morphology0.10761153
133MP0004858_abnormal_nervous_system0.10342722
134MP0000462_abnormal_digestive_system0.10086772
135MP0003011_delayed_dark_adaptation0.10000015
136MP0000733_abnormal_muscle_development0.09313715
137MP0005076_abnormal_cell_differentiation0.08970286
138MP0003045_fibrosis0.08924689
139MP0002006_tumorigenesis0.08657674
140MP0000428_abnormal_craniofacial_morphol0.07943551
141MP0006138_congestive_heart_failure0.07890410
142MP0002166_altered_tumor_susceptibility0.07837371
143MP0005508_abnormal_skeleton_morphology0.07211966
144MP0008961_abnormal_basal_metabolism0.07206359

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.80286432
2Nail dystrophy (HP:0008404)7.50101496
3Premature rupture of membranes (HP:0001788)7.15488886
4Protrusio acetabuli (HP:0003179)6.87722932
5Abnormality of nail color (HP:0100643)6.52784098
6Fragile nails (HP:0001808)5.57037123
7Abnormal hair laboratory examination (HP:0003328)5.53717440
8Fine hair (HP:0002213)5.32847697
9Alopecia of scalp (HP:0002293)5.05726684
10Palmoplantar hyperkeratosis (HP:0000972)4.98694010
11Aortic aneurysm (HP:0004942)4.96618131
12Thick nail (HP:0001805)4.81050072
13Onycholysis (HP:0001806)4.74787042
14Palmar hyperkeratosis (HP:0010765)4.70498516
15Increased IgE level (HP:0003212)4.55106370
16Plantar hyperkeratosis (HP:0007556)4.52878328
17Aortic dissection (HP:0002647)4.48420050
18Ankle contracture (HP:0006466)4.42900116
19Follicular hyperkeratosis (HP:0007502)4.36099016
20Type 1 muscle fiber predominance (HP:0003803)4.17747231
21Soft skin (HP:0000977)4.16988295
22Right ventricular cardiomyopathy (HP:0011663)4.16760541
23Vascular tortuosity (HP:0004948)4.16397823
24Neonatal short-limb short stature (HP:0008921)3.83216453
25Abnormality of dentin (HP:0010299)3.82559070
26Bladder diverticulum (HP:0000015)3.68423642
27Erythema (HP:0010783)3.51819303
28Sparse eyelashes (HP:0000653)3.51436548
29Cervical subluxation (HP:0003308)3.48955976
30Oral leukoplakia (HP:0002745)3.47226230
31Arterial tortuosity (HP:0005116)3.39896840
32Genu recurvatum (HP:0002816)3.36433769
33Broad metatarsal (HP:0001783)3.35803708
34Milia (HP:0001056)3.32466968
35Wormian bones (HP:0002645)3.26560205
36Spinal rigidity (HP:0003306)3.22581665
37Slender build (HP:0001533)3.16584228
38Spondylolisthesis (HP:0003302)3.10569363
39Erythroderma (HP:0001019)3.01734753
40Abnormality of the frontal sinuses (HP:0002687)3.01077534
41Fragile skin (HP:0001030)2.98198298
42Parakeratosis (HP:0001036)2.97700369
43Amelogenesis imperfecta (HP:0000705)2.97262008
44Dilatation of the ascending aorta (HP:0005111)2.92781449
45Peritonitis (HP:0002586)2.84734718
46Blue sclerae (HP:0000592)2.81489675
47Mesomelia (HP:0003027)2.74421047
48Ridged nail (HP:0001807)2.73698749
49Curly hair (HP:0002212)2.70164628
50Shallow orbits (HP:0000586)2.69385116
51Bowel diverticulosis (HP:0005222)2.64600932
52Coronal craniosynostosis (HP:0004440)2.63821999
53Biconcave vertebral bodies (HP:0004586)2.63516440
54Vertebral compression fractures (HP:0002953)2.63125953
55Aortic regurgitation (HP:0001659)2.62036114
56Intention tremor (HP:0002080)2.59852377
57Absent hair (HP:0002298)2.55922525
58Congenital, generalized hypertrichosis (HP:0004540)2.54009802
59Congenital ichthyosiform erythroderma (HP:0007431)2.53629031
60Elbow flexion contracture (HP:0002987)2.51816128
61Abnormal blistering of the skin (HP:0008066)2.48492336
62Natal tooth (HP:0000695)2.39776339
63Joint laxity (HP:0001388)2.39710434
64Dry hair (HP:0011359)2.39427916
65Hypoventilation (HP:0002791)2.39193064
66Joint stiffness (HP:0001387)2.38936454
67Mitral regurgitation (HP:0001653)2.38777869
68Absent eyebrow (HP:0002223)2.36990247
69Aplasia cutis congenita (HP:0001057)2.36844591
70Overgrowth (HP:0001548)2.36043558
71Neck muscle weakness (HP:0000467)2.35917839
72Wide anterior fontanel (HP:0000260)2.34621976
73Hyperextensible skin (HP:0000974)2.33182801
74Mildly elevated creatine phosphokinase (HP:0008180)2.31488962
75Torticollis (HP:0000473)2.29552553
76Advanced eruption of teeth (HP:0006288)2.25147671
77Abnormality of the acetabulum (HP:0003170)2.24550967
78Increased variability in muscle fiber diameter (HP:0003557)2.19821147
79Abnormal delivery (HP:0001787)2.18953028
80Hypohidrosis (HP:0000966)2.15331541
81Corneal erosion (HP:0200020)2.14277466
82Mitral valve prolapse (HP:0001634)2.13203347
83Redundant skin (HP:0001582)2.11364675
84Palmoplantar keratoderma (HP:0000982)2.08494808
85Mild short stature (HP:0003502)2.07927220
86Ovoid vertebral bodies (HP:0003300)2.05301891
87Aortic valve stenosis (HP:0001650)2.04553857
88Osteolytic defects of the phalanges of the hand (HP:0009771)2.02643083
89Osteolytic defects of the hand bones (HP:0009699)2.02643083
90Deformed tarsal bones (HP:0008119)2.01733240
91Wrist flexion contracture (HP:0001239)2.00129775
92Hypotrichosis (HP:0001006)14.9346183
93Slow-growing hair (HP:0002217)11.3092699
94Abnormality of hair growth rate (HP:0011363)11.3092699
95Woolly hair (HP:0002224)10.9456528
96Brittle hair (HP:0002299)10.5065750
97Breech presentation (HP:0001623)1.99742542
98Ventricular tachycardia (HP:0004756)1.99104267
99Nonimmune hydrops fetalis (HP:0001790)1.98198131
100Flared iliac wings (HP:0002869)1.97823798
101Craniofacial dystonia (HP:0012179)1.93110956
102Aneurysm (HP:0002617)1.92792194
103Cardiovascular calcification (HP:0011915)1.90335217
104Pruritus (HP:0000989)1.89961664
105Deviation of the hallux (HP:0010051)1.83994841
106Difficulty walking (HP:0002355)1.83186622
107Ulnar deviation of the wrist (HP:0003049)1.82991701
108Calcaneovalgus deformity (HP:0001848)1.81836816
109Ulnar bowing (HP:0003031)1.81381478
110Delayed closure of the anterior fontanelle (HP:0001476)1.81367471
111Camptodactyly of toe (HP:0001836)1.81273115
112Hallux valgus (HP:0001822)1.80418500
113Abnormality of skeletal muscle fiber size (HP:0012084)1.80071370
114Abnormality of the pupil (HP:0000615)1.79861632
115Conjunctival hamartoma (HP:0100780)1.79342061
116Short nail (HP:0001799)1.79341551
117Knee flexion contracture (HP:0006380)1.77790946
118Abnormality of the parietal bone (HP:0002696)1.76195159
119Focal dystonia (HP:0004373)1.76175508
120Ventricular fibrillation (HP:0001663)1.74648912
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74216772
122Abnormality of the dental root (HP:0006486)1.74064128
123Taurodontia (HP:0000679)1.74064128
124Abnormality of permanent molar morphology (HP:0011071)1.74064128
125Abnormality of the neuromuscular junction (HP:0003398)1.72974489
126Fatigable weakness (HP:0003473)1.72974489
127Concave nail (HP:0001598)1.71129355
128Abnormality of molar (HP:0011077)1.70942275
129Abnormality of molar morphology (HP:0011070)1.70942275
130Spinal cord lesions (HP:0100561)1.70432179
131Syringomyelia (HP:0003396)1.70432179
132Broad ribs (HP:0000885)1.70039285
133Abnormality of dental color (HP:0011073)1.68770668
134Generalized amyotrophy (HP:0003700)1.67054478
135Absent eyelashes (HP:0000561)1.66653404
136Mitral stenosis (HP:0001718)1.66652945
137Distal upper limb amyotrophy (HP:0007149)1.65883378
138Upper limb amyotrophy (HP:0009129)1.65883378
139Blepharitis (HP:0000498)1.60392420
140Recurrent corneal erosions (HP:0000495)1.59830409
141Widely patent fontanelles and sutures (HP:0004492)1.59591557
142Abnormality of the dental pulp (HP:0006479)1.51824280
143Hyporeflexia of lower limbs (HP:0002600)1.51706618
144Abnormality of the aortic arch (HP:0012303)1.49956297
145Unilateral renal agenesis (HP:0000122)1.49333268
146Heterogeneous (HP:0001425)1.46532262
147Abnormality of placental membranes (HP:0011409)1.45136477
148Amniotic constriction ring (HP:0009775)1.45136477
149Acanthosis nigricans (HP:0000956)1.44756745
150Carious teeth (HP:0000670)1.42483677
151Sudden death (HP:0001699)1.42334800
152Gangrene (HP:0100758)1.39885498
153Lip pit (HP:0100267)1.39215961
154Anonychia (HP:0001798)1.38414487
155Ectropion (HP:0000656)1.36393067
156Distal lower limb muscle weakness (HP:0009053)1.33662442
157Keratoconjunctivitis sicca (HP:0001097)1.33455421
158Autoamputation (HP:0001218)1.33113679
159Hypergammaglobulinemia (HP:0010702)1.32528411
160Abnormality of the fingernails (HP:0001231)1.31146493
161Achilles tendon contracture (HP:0001771)1.31094204
162Laryngomalacia (HP:0001601)1.30888744
163Craniofacial hyperostosis (HP:0004493)1.27262900
164Neonatal onset (HP:0003623)1.24952426
165Atrophic scars (HP:0001075)1.23259559
166Abnormality of the Achilles tendon (HP:0005109)1.23019351
167Variable expressivity (HP:0003828)1.21716341
168Round ear (HP:0100830)1.21051466
169Lack of skin elasticity (HP:0100679)1.19137675
170Hyperhidrosis (HP:0000975)1.17885926
171Keratoconjunctivitis (HP:0001096)1.17062230
172Corneal dystrophy (HP:0001131)1.15399604
173Selective tooth agenesis (HP:0001592)1.15249700
174Widely spaced teeth (HP:0000687)1.12916320
175Sparse scalp hair (HP:0002209)1.12510877
176Abnormality of the gastric mucosa (HP:0004295)1.10155914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK6.32973038
2EPHA24.59722489
3FER4.08968343
4MAPKAPK34.01269707
5ERN13.83338949
6NEK93.71389364
7MAP3K63.54663991
8TAOK13.26325423
9EPHB23.16122212
10MAP3K33.12743058
11TRIB32.56948956
12MAP3K112.45365780
13LATS12.45108457
14PRKD22.39508522
15MAP3K22.38067377
16RPS6KB22.17614715
17AKT31.98749700
18TTN1.71217114
19EPHB11.70931687
20EEF2K1.70256736
21MAP2K61.66647978
22LATS21.64299606
23PIK3CG1.58924296
24CDC42BPA1.46426458
25NTRK11.42130474
26PRKD31.40424925
27MAP2K31.38269980
28BCR1.35902332
29ROCK11.35663282
30MAP3K11.33056696
31FLT31.27517830
32FGFR21.26968940
33FGFR41.24298833
34GRK71.22136986
35CDK61.20920393
36NME11.19526366
37MST1R1.18884371
38DAPK31.16584178
39BMX1.15770294
40MAPKAPK21.14770690
41MOS1.13060797
42ROCK21.12287820
43FGFR11.12191182
44BLK1.09635083
45KSR21.09533204
46DMPK1.09028038
47RIPK11.08986924
48TESK11.08690203
49KIT1.06897140
50PTK21.06791035
51PKN21.05122889
52PDGFRA1.04599664
53ABL21.04347131
54LRRK21.02882128
55PTK61.02363018
56MAPK70.99506993
57FGFR30.98397850
58DAPK20.93610175
59PDGFRB0.92177768
60PBK0.90079253
61ADRBK10.89992031
62MAP3K70.88129994
63RPS6KA40.86398585
64MAP3K90.84737751
65PLK20.84646340
66PIM20.83353998
67PTK2B0.83214795
68MAP2K40.81743179
69STK38L0.80352027
70PAK30.78521716
71TGFBR20.77767913
72PRKG20.77698684
73MAP2K10.77169754
74STK240.76992527
75STK380.74179974
76PAK40.73610879
77SIK10.72029970
78DYRK1B0.69375670
79MET0.68196002
80DDR20.67998339
81PAK10.67362523
82MAP3K50.64977017
83PDK20.64285314
84TRPM70.62509388
85PRKCE0.61725094
86STK30.60827426
87PRKD10.60576201
88LIMK10.60109319
89PRKCI0.57953163
90RPS6KA20.55577025
91RAF10.54475515
92MAP3K100.54175448
93PAK20.53454103
94ERBB40.53313636
95MST40.53240142
96PRKCH0.53121091
97ARAF0.50896400
98ERBB30.49744803
99TYRO30.47404014
100JAK10.46664549
101PIK3CA0.46389445
102PAK60.44994840
103CDK190.44564200
104EPHA30.44483160
105CAMK2G0.43915776
106ERBB20.43668890
107CDK80.43579535
108RET0.42704247
109NTRK20.41982963
110JAK30.41717118
111TYK20.40707613
112RPS6KA10.40560048
113GSK3A0.40537209
114TGFBR10.40460758
115ALK0.39794329
116GRK50.39358636
117SCYL20.38097615
118MTOR0.38074254
119STK100.37771135
120GRK10.37036200
121CSNK1E0.36998141
122PRPF4B0.35441783
123ABL10.35208137
124TAOK20.34910066
125PRKCD0.34263816
126MAPK120.33574992
127INSR0.33221230
128JAK20.32814300
129ILK0.30433140
130MAP2K20.30399754
131MAP3K80.27850980
132NEK10.27681509
133OBSCN0.27603736
134MELK0.26798054
135ADRBK20.26580136
136ICK0.26363736
137CLK10.26134806
138WNK10.25370347
139RPS6KC10.25050928
140RPS6KL10.25050928
141FYN0.24183279
142SRC0.23982078
143ZAP700.23435271
144GRK60.23069446
145IKBKE0.21888490
146MAPK40.20775162
147HCK0.20538726
148MAP3K120.19717499
149PRKACG0.19705292
150CSNK1A10.19670220
151CAMK2D0.19620751
152CAMK10.15512762

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.98905432
2Linoleic acid metabolism_Homo sapiens_hsa005914.94555061
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.48533293
4Fat digestion and absorption_Homo sapiens_hsa049753.12467946
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.81389663
6Fatty acid elongation_Homo sapiens_hsa000622.68769569
7Ether lipid metabolism_Homo sapiens_hsa005652.56044993
8Basal cell carcinoma_Homo sapiens_hsa052172.16734130
9Arachidonic acid metabolism_Homo sapiens_hsa005902.10241605
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.05360325
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90610761
12Phenylalanine metabolism_Homo sapiens_hsa003601.84744172
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81886162
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80322092
15Dilated cardiomyopathy_Homo sapiens_hsa054141.76175242
16VEGF signaling pathway_Homo sapiens_hsa043701.69911493
17Bladder cancer_Homo sapiens_hsa052191.63128340
18Vibrio cholerae infection_Homo sapiens_hsa051101.62396968
19Melanoma_Homo sapiens_hsa052181.61329039
20Melanogenesis_Homo sapiens_hsa049161.52684372
21PI3K-Akt signaling pathway_Homo sapiens_hsa041511.51758251
22Axon guidance_Homo sapiens_hsa043601.49827887
23Histidine metabolism_Homo sapiens_hsa003401.41229944
24Thyroid cancer_Homo sapiens_hsa052161.35261084
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34908185
26Sphingolipid metabolism_Homo sapiens_hsa006001.33379949
27Proteoglycans in cancer_Homo sapiens_hsa052051.31866789
28Hedgehog signaling pathway_Homo sapiens_hsa043401.31615354
29Caffeine metabolism_Homo sapiens_hsa002321.31369880
30Acute myeloid leukemia_Homo sapiens_hsa052211.30318731
31Hippo signaling pathway_Homo sapiens_hsa043901.30225551
32Glioma_Homo sapiens_hsa052141.29823250
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.28705648
34Lysosome_Homo sapiens_hsa041421.28041983
35GnRH signaling pathway_Homo sapiens_hsa049121.23452431
36Other glycan degradation_Homo sapiens_hsa005111.23230161
37Malaria_Homo sapiens_hsa051441.22860870
38Tight junction_Homo sapiens_hsa045301.17249306
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17021581
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13716058
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13222118
42ECM-receptor interaction_Homo sapiens_hsa045121.11860226
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09191603
44Mineral absorption_Homo sapiens_hsa049781.06585511
45Pancreatic secretion_Homo sapiens_hsa049721.06441379
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05894795
47Adherens junction_Homo sapiens_hsa045201.05185031
48Sulfur metabolism_Homo sapiens_hsa009201.02583268
49PPAR signaling pathway_Homo sapiens_hsa033201.00477464
50Dorso-ventral axis formation_Homo sapiens_hsa043200.97399122
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96885345
52Long-term potentiation_Homo sapiens_hsa047200.94117750
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93832387
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92881525
55Steroid biosynthesis_Homo sapiens_hsa001000.92396486
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.92077250
57Small cell lung cancer_Homo sapiens_hsa052220.91687164
58Tyrosine metabolism_Homo sapiens_hsa003500.90670535
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.87382491
60Endometrial cancer_Homo sapiens_hsa052130.86983858
61Pertussis_Homo sapiens_hsa051330.86955349
62Nitrogen metabolism_Homo sapiens_hsa009100.84042918
63Amoebiasis_Homo sapiens_hsa051460.83795705
64Non-small cell lung cancer_Homo sapiens_hsa052230.83608725
65Phagosome_Homo sapiens_hsa041450.83255491
66Endocytosis_Homo sapiens_hsa041440.82425985
67Estrogen signaling pathway_Homo sapiens_hsa049150.82159734
68Ras signaling pathway_Homo sapiens_hsa040140.81405275
69Wnt signaling pathway_Homo sapiens_hsa043100.76160476
70Long-term depression_Homo sapiens_hsa047300.75861181
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73951522
72beta-Alanine metabolism_Homo sapiens_hsa004100.73741985
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72903620
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.72365055
75Staphylococcus aureus infection_Homo sapiens_hsa051500.71688985
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69704377
77Renin-angiotensin system_Homo sapiens_hsa046140.65744320
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65168077
79MicroRNAs in cancer_Homo sapiens_hsa052060.64298281
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63789389
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.62203404
82Renin secretion_Homo sapiens_hsa049240.61846448
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61843659
84Vitamin digestion and absorption_Homo sapiens_hsa049770.61718109
85Hepatitis C_Homo sapiens_hsa051600.60760091
86N-Glycan biosynthesis_Homo sapiens_hsa005100.60204897
87Gastric acid secretion_Homo sapiens_hsa049710.59843815
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59552982
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58633595
90Focal adhesion_Homo sapiens_hsa045100.58038564
91Phototransduction_Homo sapiens_hsa047440.57206818
92Rap1 signaling pathway_Homo sapiens_hsa040150.56414630
93Chemical carcinogenesis_Homo sapiens_hsa052040.55879753
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.54584443
95MAPK signaling pathway_Homo sapiens_hsa040100.54260701
96Insulin resistance_Homo sapiens_hsa049310.53776135
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.53460967
98Protein digestion and absorption_Homo sapiens_hsa049740.53305865
99Gap junction_Homo sapiens_hsa045400.52832068
100Salmonella infection_Homo sapiens_hsa051320.52515358
101p53 signaling pathway_Homo sapiens_hsa041150.50689951
102Prostate cancer_Homo sapiens_hsa052150.50414995
103TGF-beta signaling pathway_Homo sapiens_hsa043500.50204112
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50020065
105Complement and coagulation cascades_Homo sapiens_hsa046100.48557007
106Calcium signaling pathway_Homo sapiens_hsa040200.48505109
107ErbB signaling pathway_Homo sapiens_hsa040120.47564287
108Cocaine addiction_Homo sapiens_hsa050300.46800051
109Fatty acid metabolism_Homo sapiens_hsa012120.46695957
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.46407819
111Renal cell carcinoma_Homo sapiens_hsa052110.46284585
112TNF signaling pathway_Homo sapiens_hsa046680.46100939
113Platelet activation_Homo sapiens_hsa046110.45882076
114Salivary secretion_Homo sapiens_hsa049700.45295160
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44696427
116Chronic myeloid leukemia_Homo sapiens_hsa052200.44303100
117Oxytocin signaling pathway_Homo sapiens_hsa049210.44132646
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43445373
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42224768
120Toxoplasmosis_Homo sapiens_hsa051450.42142629
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40446531
122Tuberculosis_Homo sapiens_hsa051520.40271787
123Protein export_Homo sapiens_hsa030600.39097344
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38713615
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38392252
126cAMP signaling pathway_Homo sapiens_hsa040240.38287283
127Notch signaling pathway_Homo sapiens_hsa043300.37437138
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36954590
129Butanoate metabolism_Homo sapiens_hsa006500.34946857
130Prolactin signaling pathway_Homo sapiens_hsa049170.34599702
131Prion diseases_Homo sapiens_hsa050200.34511984
132Pathways in cancer_Homo sapiens_hsa052000.33690491
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33565844
134Galactose metabolism_Homo sapiens_hsa000520.33340139
135Fatty acid degradation_Homo sapiens_hsa000710.33042736
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31892642
137Shigellosis_Homo sapiens_hsa051310.31398764
138Retinol metabolism_Homo sapiens_hsa008300.30970713
139Glutathione metabolism_Homo sapiens_hsa004800.27873885
140Hepatitis B_Homo sapiens_hsa051610.25162439
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24798905
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23869294

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