KRTAP10-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.97836248
2adhesion of symbiont to host cell (GO:0044650)9.97836248
3citrulline biosynthetic process (GO:0019240)9.12405073
4adhesion of symbiont to host (GO:0044406)8.41079390
5hair follicle morphogenesis (GO:0031069)8.17790148
6peptide cross-linking (GO:0018149)8.01967960
7cell wall macromolecule catabolic process (GO:0016998)6.90835878
8cell wall macromolecule metabolic process (GO:0044036)6.90835878
9intermediate filament cytoskeleton organization (GO:0045104)6.46963305
10intermediate filament-based process (GO:0045103)6.26172323
11epidermis development (GO:0008544)6.07132562
12citrulline metabolic process (GO:0000052)6.03577293
13keratinocyte differentiation (GO:0030216)5.60338710
14molting cycle process (GO:0022404)5.36440314
15hair cycle process (GO:0022405)5.36440314
16establishment of skin barrier (GO:0061436)5.16359649
17peptidyl-arginine modification (GO:0018195)5.04714918
18bundle of His cell to Purkinje myocyte communication (GO:0086069)5.04259502
19skin morphogenesis (GO:0043589)4.96990643
20hemidesmosome assembly (GO:0031581)4.70281260
21regulation of water loss via skin (GO:0033561)4.60230385
22epidermal cell differentiation (GO:0009913)4.39080428
23tooth mineralization (GO:0034505)4.11922525
24molting cycle (GO:0042303)34.7214904
25hair cycle (GO:0042633)34.7214904
26keratinocyte development (GO:0003334)3.85795880
27positive regulation of hair cycle (GO:0042635)3.38300823
28positive regulation of hair follicle development (GO:0051798)3.38300823
29negative regulation of keratinocyte proliferation (GO:0010839)3.29326832
30hair follicle development (GO:0001942)3.26999517
31phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19764866
32regulation of keratinocyte differentiation (GO:0045616)3.15154104
33regulation of hair follicle development (GO:0051797)3.13410027
34multicellular organismal water homeostasis (GO:0050891)3.11533018
35negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.10360638
36bone trabecula formation (GO:0060346)3.01026161
37phosphatidylserine acyl-chain remodeling (GO:0036150)2.94896654
38epithelium development (GO:0060429)2.88153493
39fatty acid elongation (GO:0030497)2.86558356
40positive regulation of meiotic cell cycle (GO:0051446)2.77872021
41positive regulation of epidermis development (GO:0045684)2.74435530
42phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.73800180
43atrioventricular valve morphogenesis (GO:0003181)2.73202864
44regulation of hair cycle (GO:0042634)2.68926342
45gap junction assembly (GO:0016264)2.68215457
46ectoderm development (GO:0007398)2.66824277
47water homeostasis (GO:0030104)2.57050262
48negative regulation of protein localization to plasma membrane (GO:1903077)2.54181018
49regulation of mesenchymal cell apoptotic process (GO:2001053)2.48158358
50epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47935054
51lymph vessel development (GO:0001945)2.45492141
52regulation of epidermal cell differentiation (GO:0045604)2.44291446
53regulation of epidermis development (GO:0045682)2.41794452
54negative regulation of cell fate specification (GO:0009996)2.40110894
55ventricular cardiac muscle cell action potential (GO:0086005)2.30620110
56cell surface receptor signaling pathway involved in heart development (GO:0061311)2.24564593
57phosphatidylserine metabolic process (GO:0006658)2.24076261
58wound healing, spreading of epidermal cells (GO:0035313)2.22016768
59positive regulation of epidermal cell differentiation (GO:0045606)2.18715284
60myotube differentiation (GO:0014902)2.18416142
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.13741064
62skin development (GO:0043588)2.12626212
63regulation of ruffle assembly (GO:1900027)2.11266697
64cranial suture morphogenesis (GO:0060363)2.09998498
65positive regulation of monocyte chemotaxis (GO:0090026)2.07497646
66outflow tract septum morphogenesis (GO:0003148)2.07397793
67negative regulation of epidermis development (GO:0045683)2.06125197
68regulation of cardioblast differentiation (GO:0051890)2.03779173
69aging (GO:0007568)2.02784012
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.01171508
71regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.00486277
72intermediate filament organization (GO:0045109)11.9317408
73keratinization (GO:0031424)10.5475939
74desmosome organization (GO:0002934)10.1429181
75epithelial cell-cell adhesion (GO:0090136)1.99849058
76planar cell polarity pathway involved in neural tube closure (GO:0090179)1.94157928
77regulation of heart rate by cardiac conduction (GO:0086091)1.92467665
78phosphatidylcholine acyl-chain remodeling (GO:0036151)1.90006964
79coronary vasculature morphogenesis (GO:0060977)1.88550871
80ephrin receptor signaling pathway (GO:0048013)1.88105700
81regulation of keratinocyte proliferation (GO:0010837)1.87695118
82non-canonical Wnt signaling pathway (GO:0035567)1.86134856
83regulation of secondary heart field cardioblast proliferation (GO:0003266)1.84856668
84regulation of cardioblast proliferation (GO:0003264)1.84856668
85cell communication involved in cardiac conduction (GO:0086065)1.84264865
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.78586057
87cardiac right ventricle morphogenesis (GO:0003215)1.74806997
88cell-substrate junction assembly (GO:0007044)1.74371818
89outer ear morphogenesis (GO:0042473)1.72778316
90very long-chain fatty acid metabolic process (GO:0000038)1.71735742
91regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.71155915
92negative regulation of cell fate commitment (GO:0010454)1.69580048
93antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.69458215
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.69458215
95long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.67969185
96alditol phosphate metabolic process (GO:0052646)1.66066241
97negative regulation of epidermal cell differentiation (GO:0045605)1.63797870
98establishment of tissue polarity (GO:0007164)1.62614670
99establishment of planar polarity (GO:0001736)1.62614670
100negative regulation of Ras GTPase activity (GO:0034261)1.61553748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.18327956
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.74866428
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.48795869
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70564547
5CTCF_20526341_ChIP-Seq_ESCs_Human2.26298324
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.10649736
7* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.03644833
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.6353455
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91849752
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.78936707
11TAF2_19829295_ChIP-Seq_ESCs_Human1.78507720
12E2F1_20622854_ChIP-Seq_HELA_Human1.74359955
13SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72635568
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.70789963
15EGR1_19032775_ChIP-ChIP_M12_Human1.69381984
16NANOG_20526341_ChIP-Seq_ESCs_Human1.64716740
17TP53_20018659_ChIP-ChIP_R1E_Mouse1.62325592
18ERG_20517297_ChIP-Seq_VCAP_Human1.55914536
19* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.52431670
20* CTCF_27219007_Chip-Seq_Bcells_Human1.48936346
21P53_21459846_ChIP-Seq_SAOS-2_Human1.48225103
22RACK7_27058665_Chip-Seq_MCF-7_Human1.47998289
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.45527049
24MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.45437619
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44918497
26TP63_22573176_ChIP-Seq_HFKS_Human1.44906726
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41764879
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41764879
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.41059684
30* LXR_22292898_ChIP-Seq_THP-1_Human1.40754128
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.39758468
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34463343
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32395806
34BCOR_27268052_Chip-Seq_Bcells_Human1.31316850
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29209099
36ATF3_27146783_Chip-Seq_COLON_Human1.28991213
37* BCL6_27268052_Chip-Seq_Bcells_Human1.28974819
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27838566
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26568864
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.24265781
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.22409462
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22007219
43AHR_22903824_ChIP-Seq_MCF-7_Human1.21357407
44PHF8_20622854_ChIP-Seq_HELA_Human1.20552171
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20409161
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19151800
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.15664063
48P68_20966046_ChIP-Seq_HELA_Human1.14963654
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14315629
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14103626
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13857802
52CEBPB_22108803_ChIP-Seq_LS180_Human1.13461642
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.13059683
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12800233
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10348120
56SMC4_20622854_ChIP-Seq_HELA_Human1.09159159
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06632771
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.06462252
59E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04982440
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.04763988
61GATA4_25053715_ChIP-Seq_YYC3_Human1.04260790
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04244263
63TP63_23658742_ChIP-Seq_EP156T_Human1.02640228
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02147001
65UBF1/2_26484160_Chip-Seq_HMECs_Human1.01530847
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01343228
67KLF5_25053715_ChIP-Seq_YYC3_Human0.97653945
68ERG_21242973_ChIP-ChIP_JURKAT_Human0.97653743
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96473685
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95590113
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94381425
72RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93896518
73AR_21572438_ChIP-Seq_LNCaP_Human0.92581010
74RING1B_27294783_Chip-Seq_ESCs_Mouse0.92242431
75* RAC3_21632823_ChIP-Seq_H3396_Human0.91887522
76TP53_18474530_ChIP-ChIP_U2OS_Human0.91354635
77GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90945416
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90520341
79SPI1_20517297_ChIP-Seq_HL60_Human0.90313229
80ZNF263_19887448_ChIP-Seq_K562_Human0.87793805
81FOXH1_21741376_ChIP-Seq_ESCs_Human0.87433867
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86224220
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85940502
84* SOX2_21211035_ChIP-Seq_LN229_Human0.85581696
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.85458972
86RUNX1_27514584_Chip-Seq_MCF-7_Human0.85370428
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85009880
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.83717187
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.82287926
90SOX2_20726797_ChIP-Seq_SW620_Human0.82121408
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80476078
92RXR_22108803_ChIP-Seq_LS180_Human0.78739585
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77752455
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77637764
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77489205
96EZH2_27304074_Chip-Seq_ESCs_Mouse0.77370015
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.77024666
98TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75915985
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75197315
100EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74253457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.60641557
2MP0002098_abnormal_vibrissa_morphology7.25685082
3MP0000647_abnormal_sebaceous_gland6.56260169
4MP0002796_impaired_skin_barrier5.91571677
5MP0010234_abnormal_vibrissa_follicle5.16862112
6MP0005275_abnormal_skin_tensile5.02119864
7MP0000383_abnormal_hair_follicle4.57410612
8MP0000377_abnormal_hair_follicle4.11226679
9MP0010678_abnormal_skin_adnexa4.04343391
10MP0003705_abnormal_hypodermis_morpholog3.65956263
11MP0005501_abnormal_skin_physiology3.65240679
12MP0000427_abnormal_hair_cycle3.54623777
13MP0002254_reproductive_system_inflammat3.21850728
14MP0001216_abnormal_epidermal_layer2.64488050
15MP0004381_abnormal_hair_follicle2.52759800
16MP0000367_abnormal_coat/_hair2.37419352
17MP0010771_integument_phenotype2.26835719
18MP0004947_skin_inflammation2.20957689
19MP0001243_abnormal_dermal_layer2.18700604
20MP0002060_abnormal_skin_morphology2.14816680
21MP0003453_abnormal_keratinocyte_physiol2.13650316
22MP0002234_abnormal_pharynx_morphology2.06217700
23MP0000467_abnormal_esophagus_morphology1.69220406
24MP0009931_abnormal_skin_appearance1.47593228
25MP0009053_abnormal_anal_canal1.44316201
26MP0000762_abnormal_tongue_morphology1.43544838
27MP0003566_abnormal_cell_adhesion1.35871010
28MP0005409_darkened_coat_color1.21056050
29MP0003941_abnormal_skin_development1.19904536
30MP0001191_abnormal_skin_condition0.98190724
31MP0004185_abnormal_adipocyte_glucose0.96530708
32MP0004885_abnormal_endolymph0.92523564
33MP0002095_abnormal_skin_pigmentation0.82461421
34MP0001346_abnormal_lacrimal_gland0.80962948
35MP0004264_abnormal_extraembryonic_tissu0.77206843
36MP0001851_eye_inflammation0.76728859
37MP0001340_abnormal_eyelid_morphology0.68184453
38MP0003315_abnormal_perineum_morphology0.63253421
39MP0001849_ear_inflammation0.63125707
40MP0008438_abnormal_cutaneous_collagen0.62979186
41MP0001661_extended_life_span0.59526874
42MP0000627_abnormal_mammary_gland0.57690479
43MP0002877_abnormal_melanocyte_morpholog0.56938232
44MP0010030_abnormal_orbit_morphology0.56125937
45MP0000566_synostosis0.54348341
46MP0002249_abnormal_larynx_morphology0.52954272
47MP0002282_abnormal_trachea_morphology0.51572077
48MP0000678_abnormal_parathyroid_gland0.49770737
49MP0003755_abnormal_palate_morphology0.49312598
50MP0005451_abnormal_body_composition0.48296155
51MP0003191_abnormal_cellular_cholesterol0.47611113
52MP0005023_abnormal_wound_healing0.46872085
53MP0002970_abnormal_white_adipose0.45114153
54MP0001784_abnormal_fluid_regulation0.44296833
55MP0002111_abnormal_tail_morphology0.40014456
56MP0005075_abnormal_melanosome_morpholog0.37583463
57MP0003385_abnormal_body_wall0.33636856
58MP0010352_gastrointestinal_tract_polyps0.33125376
59MP0004272_abnormal_basement_membrane0.32444400
60MP0000537_abnormal_urethra_morphology0.27281426
61MP0002177_abnormal_outer_ear0.27212067
62MP0009840_abnormal_foam_cell0.26699029
63MP0005248_abnormal_Harderian_gland0.26035347
64MP0003763_abnormal_thymus_physiology0.22985222
65MP0002697_abnormal_eye_size0.22794307
66MP0009379_abnormal_foot_pigmentation0.21273439
67MP0001879_abnormal_lymphatic_vessel0.21206723
68MP0003950_abnormal_plasma_membrane0.20468032
69MP0003329_amyloid_beta_deposits0.20258071
70MP0004019_abnormal_vitamin_homeostasis0.19725192
71MP0004858_abnormal_nervous_system0.19705382
72MP0000465_gastrointestinal_hemorrhage0.19326356
73MP0000432_abnormal_head_morphology0.18837269
74MP0004742_abnormal_vestibular_system0.18215398
75MP0003300_gastrointestinal_ulcer0.18027548
76MP0000516_abnormal_urinary_system0.17888561
77MP0005367_renal/urinary_system_phenotyp0.17888561
78MP0003638_abnormal_response/metabolism_0.16950320
79MP0005666_abnormal_adipose_tissue0.16358183
80MP0009384_cardiac_valve_regurgitation0.16303067
81MP0003935_abnormal_craniofacial_develop0.15785041
82MP0005375_adipose_tissue_phenotype0.15703709
83MP0003011_delayed_dark_adaptation0.15459819
84MP0000751_myopathy0.13595347
85MP0000733_abnormal_muscle_development0.13317741
86MP0003075_altered_response_to0.13160873
87MP0003045_fibrosis0.13053083
88MP0002006_tumorigenesis0.12430269
89MP0005076_abnormal_cell_differentiation0.11793184
90MP0002166_altered_tumor_susceptibility0.11761058
91MP0003448_altered_tumor_morphology0.11732162
92MP0006054_spinal_hemorrhage0.11663799
93MP0005165_increased_susceptibility_to0.09833916
94MP0000604_amyloidosis0.09303132
95MP0006138_congestive_heart_failure0.09118864
96MP0000013_abnormal_adipose_tissue0.08445278
97MP0002233_abnormal_nose_morphology0.08283962
98MP0000428_abnormal_craniofacial_morphol0.07618741
99MP0002009_preneoplasia0.07439624
100MP0003436_decreased_susceptibility_to0.07407247

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.15098259
2Nail dystrophy (HP:0008404)7.23989046
3Abnormality of nail color (HP:0100643)6.00956302
4Abnormal hair laboratory examination (HP:0003328)5.77432663
5Fragile nails (HP:0001808)5.66098639
6Fine hair (HP:0002213)5.14054573
7Onycholysis (HP:0001806)5.06318882
8Alopecia of scalp (HP:0002293)4.76423805
9Increased IgE level (HP:0003212)4.69294817
10Palmoplantar hyperkeratosis (HP:0000972)4.61954300
11Palmar hyperkeratosis (HP:0010765)4.33792731
12Plantar hyperkeratosis (HP:0007556)4.25420556
13Thick nail (HP:0001805)4.22471356
14Right ventricular cardiomyopathy (HP:0011663)4.18249545
15Follicular hyperkeratosis (HP:0007502)4.14702793
16Erythema (HP:0010783)3.59611644
17Sparse eyelashes (HP:0000653)3.58884199
18Amelogenesis imperfecta (HP:0000705)3.35823834
19Oral leukoplakia (HP:0002745)3.25242908
20Abnormality of the frontal sinuses (HP:0002687)3.23954195
21Milia (HP:0001056)3.11455692
22Parakeratosis (HP:0001036)2.86266764
23Erythroderma (HP:0001019)2.81318436
24Congenital, generalized hypertrichosis (HP:0004540)2.71028938
25Curly hair (HP:0002212)2.68574634
26Aplasia cutis congenita (HP:0001057)2.65997693
27Ridged nail (HP:0001807)2.61464329
28Intention tremor (HP:0002080)2.61458276
29Neck muscle weakness (HP:0000467)2.51943572
30Natal tooth (HP:0000695)2.37738943
31Advanced eruption of teeth (HP:0006288)2.37520946
32Congenital ichthyosiform erythroderma (HP:0007431)2.35995040
33Abnormal blistering of the skin (HP:0008066)2.32386618
34Torticollis (HP:0000473)2.27076776
35Dry hair (HP:0011359)2.25175679
36Hypohidrosis (HP:0000966)2.07771282
37Corneal erosion (HP:0200020)2.04404595
38Ventricular tachycardia (HP:0004756)2.03594319
39Hypotrichosis (HP:0001006)14.7296947
40Woolly hair (HP:0002224)11.1963047
41Abnormality of hair growth rate (HP:0011363)10.9136029
42Slow-growing hair (HP:0002217)10.9136029
43Brittle hair (HP:0002299)10.1729818
44Palmoplantar keratoderma (HP:0000982)1.93782005
45Abnormality of the parietal bone (HP:0002696)1.93582251
46Pruritus (HP:0000989)1.92572807
47Difficulty walking (HP:0002355)1.92230412
48Craniofacial dystonia (HP:0012179)1.90588569
49Concave nail (HP:0001598)1.86646479
50Abnormality of permanent molar morphology (HP:0011071)1.84132268
51Abnormality of the dental root (HP:0006486)1.84132268
52Taurodontia (HP:0000679)1.84132268
53Abnormality of dental color (HP:0011073)1.82441093
54Abnormality of molar morphology (HP:0011070)1.80575230
55Abnormality of molar (HP:0011077)1.80575230
56Abnormality of the pupil (HP:0000615)1.79902579
57Widely patent fontanelles and sutures (HP:0004492)1.75445029
58Focal dystonia (HP:0004373)1.74336234
59Ventricular fibrillation (HP:0001663)1.73413421
60Unilateral renal agenesis (HP:0000122)1.73335556
61Hyporeflexia of lower limbs (HP:0002600)1.69025449
62Abnormality of the aortic arch (HP:0012303)1.66900701
63Recurrent corneal erosions (HP:0000495)1.64489462
64Absent eyelashes (HP:0000561)1.63843731
65Abnormality of the dental pulp (HP:0006479)1.60646972
66Fatigable weakness (HP:0003473)1.58810633
67Abnormality of the neuromuscular junction (HP:0003398)1.58810633
68Sudden death (HP:0001699)1.57727203
69Blepharitis (HP:0000498)1.53738186
70Round ear (HP:0100830)1.53222367
71Lip pit (HP:0100267)1.49730357
72Amniotic constriction ring (HP:0009775)1.49481345
73Abnormality of placental membranes (HP:0011409)1.49481345
74Acanthosis nigricans (HP:0000956)1.47972600
75Distal lower limb muscle weakness (HP:0009053)1.44680264
76Type 1 muscle fiber predominance (HP:0003803)1.42914736
77Heterogeneous (HP:0001425)1.42744406
78Craniofacial hyperostosis (HP:0004493)1.42312879
79Carious teeth (HP:0000670)1.39381154
80Conjunctival hamartoma (HP:0100780)1.39249885
81Hypergammaglobulinemia (HP:0010702)1.38700275
82Keratoconjunctivitis sicca (HP:0001097)1.36081268
83Anonychia (HP:0001798)1.29710375
84Achilles tendon contracture (HP:0001771)1.29039591
85Ectropion (HP:0000656)1.26306038
86Gangrene (HP:0100758)1.25138996
87Autoamputation (HP:0001218)1.24745408
88Abnormality of the fingernails (HP:0001231)1.23807840
89Widely spaced teeth (HP:0000687)1.22250027
90Sparse scalp hair (HP:0002209)1.21976701
91Increased connective tissue (HP:0009025)1.21948581
92Distal arthrogryposis (HP:0005684)1.21378064
93Abnormality of the Achilles tendon (HP:0005109)1.21291194
94Neonatal onset (HP:0003623)1.20949118
95Keratoconjunctivitis (HP:0001096)1.19438474
96Variable expressivity (HP:0003828)1.17373805
97Selective tooth agenesis (HP:0001592)1.16109232
98Atrophic scars (HP:0001075)1.14886915
99Hyperthyroidism (HP:0000836)1.13112676
100Laryngomalacia (HP:0001601)1.12071672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.32982219
2FER4.28493218
3EPHA24.04952840
4ERN13.69590044
5MAP3K63.64620062
6EPHB23.18102798
7TAOK13.08725929
8MAP3K32.68233829
9MAP3K22.44149496
10TRIB32.43680261
11PIK3CG2.37433918
12LATS12.28695317
13TTN2.17414062
14RPS6KB22.14572109
15MAP3K112.13153766
16EEF2K2.01083752
17MAP2K61.93502292
18EPHB11.64057346
19BLK1.53872041
20LATS21.45646565
21OBSCN1.42450169
22BCR1.30377340
23NME11.29957097
24FGFR41.22939096
25MAP3K11.22691913
26MAP2K31.22357592
27PIM21.21382878
28BMX1.20364509
29MAPKAPK21.14781927
30FGFR21.11555589
31CDK61.10474052
32MST1R1.10182533
33LRRK21.07642973
34PBK1.05627643
35KSR21.05071260
36FGFR30.98693688
37RIPK10.96029318
38PKN20.94467608
39FGFR10.93589601
40MAP3K70.90274224
41RPS6KA40.88744213
42PTK60.85159632
43PDGFRA0.83419119
44PRKD10.80292605
45PTK20.80097758
46DYRK1B0.80045161
47MAP2K10.77476093
48CDK190.74950435
49ERBB40.74158454
50MAP2K40.73168369
51SIK10.66477270
52MAP3K90.64591022
53PRKCI0.63309297
54TESK10.63194846
55STK380.62692345
56NTRK20.62018227
57PAK30.60191712
58TRPM70.60014974
59MET0.58253662
60PAK40.57167497
61MAPK120.52146790
62MAP3K100.51253032
63DDR20.50933771
64JAK10.50354972
65MAP3K50.49584394
66RPS6KA10.49190212
67STK38L0.49173847
68PAK20.48206712
69PRKCH0.47961570
70ERBB20.46865520
71PHKG20.46062143
72PHKG10.46062143
73TGFBR10.45913917
74CLK10.45791115
75RET0.45214260
76STK240.43381231
77EPHA40.42546017
78TYK20.41125566
79PAK60.39877669
80CSNK1E0.39790238
81EPHA30.39345063
82GSK3A0.38821550
83MAP2K20.38501485
84ALK0.35524604
85TYRO30.35148959
86FYN0.35142187
87NEK10.32498110
88STK110.32297864
89ILK0.31109062
90JAK20.30956042
91ABL20.30866170
92TGFBR20.28807013
93LIMK10.27565187
94IKBKE0.27556178
95MAP3K80.27372138
96PRKACA0.26222891
97CSNK1A10.25208336
98PRKACG0.24236958
99ROCK20.24073558
100SRC0.23945862

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.74914787
2Linoleic acid metabolism_Homo sapiens_hsa005914.65514276
3Fat digestion and absorption_Homo sapiens_hsa049753.00591620
4Fatty acid elongation_Homo sapiens_hsa000622.99740809
5Ether lipid metabolism_Homo sapiens_hsa005652.46555256
6Basal cell carcinoma_Homo sapiens_hsa052172.35286370
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82268339
8Phenylalanine metabolism_Homo sapiens_hsa003601.77152807
9VEGF signaling pathway_Homo sapiens_hsa043701.75064404
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.73601895
11Arachidonic acid metabolism_Homo sapiens_hsa005901.70426817
12Melanogenesis_Homo sapiens_hsa049161.59364788
13Axon guidance_Homo sapiens_hsa043601.55532403
14Caffeine metabolism_Homo sapiens_hsa002321.48232389
15Hedgehog signaling pathway_Homo sapiens_hsa043401.42097960
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.37574494
17Histidine metabolism_Homo sapiens_hsa003401.33163919
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.32824479
19Proteoglycans in cancer_Homo sapiens_hsa052051.29314404
20Thyroid cancer_Homo sapiens_hsa052161.27025815
21Bladder cancer_Homo sapiens_hsa052191.25536112
22Glioma_Homo sapiens_hsa052141.25158109
23Hippo signaling pathway_Homo sapiens_hsa043901.22040412
24Acute myeloid leukemia_Homo sapiens_hsa052211.20677222
25GnRH signaling pathway_Homo sapiens_hsa049121.17296716
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16645774
27Pancreatic secretion_Homo sapiens_hsa049721.15629041
28Tight junction_Homo sapiens_hsa045301.14586680
29Mineral absorption_Homo sapiens_hsa049781.08807789
30PPAR signaling pathway_Homo sapiens_hsa033201.08062893
31Dorso-ventral axis formation_Homo sapiens_hsa043201.07427832
32Pertussis_Homo sapiens_hsa051330.97863532
33Steroid biosynthesis_Homo sapiens_hsa001000.97018093
34Cyanoamino acid metabolism_Homo sapiens_hsa004600.92867115
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91630420
36ECM-receptor interaction_Homo sapiens_hsa045120.91045960
37Adherens junction_Homo sapiens_hsa045200.90732987
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89966107
39Long-term potentiation_Homo sapiens_hsa047200.89697665
40Nitrogen metabolism_Homo sapiens_hsa009100.87522304
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.86635583
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.85320416
43Amoebiasis_Homo sapiens_hsa051460.84485104
44Long-term depression_Homo sapiens_hsa047300.82483020
45Endometrial cancer_Homo sapiens_hsa052130.82439556
46beta-Alanine metabolism_Homo sapiens_hsa004100.81788888
47Tyrosine metabolism_Homo sapiens_hsa003500.79199184
48Ras signaling pathway_Homo sapiens_hsa040140.78189871
49Non-small cell lung cancer_Homo sapiens_hsa052230.78168465
50Renin secretion_Homo sapiens_hsa049240.76490097
51Estrogen signaling pathway_Homo sapiens_hsa049150.75069507
52Wnt signaling pathway_Homo sapiens_hsa043100.74681386
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74292333
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73584786
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.70010696
56Gastric acid secretion_Homo sapiens_hsa049710.69012137
57Fatty acid metabolism_Homo sapiens_hsa012120.67294349
58Staphylococcus aureus infection_Homo sapiens_hsa051500.66710934
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66265755
60Salmonella infection_Homo sapiens_hsa051320.64187326
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62757351
62Insulin resistance_Homo sapiens_hsa049310.61521113
63Phototransduction_Homo sapiens_hsa047440.57139734
64Hepatitis C_Homo sapiens_hsa051600.56921078
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56282418
66Platelet activation_Homo sapiens_hsa046110.55420859
67Rap1 signaling pathway_Homo sapiens_hsa040150.55270022
68MicroRNAs in cancer_Homo sapiens_hsa052060.55202022
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.54933304
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53409960
71Gap junction_Homo sapiens_hsa045400.52363983
72Oxytocin signaling pathway_Homo sapiens_hsa049210.50712097
73Butanoate metabolism_Homo sapiens_hsa006500.48993554
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.47878517
75Focal adhesion_Homo sapiens_hsa045100.46859734
76Salivary secretion_Homo sapiens_hsa049700.45934178
77Fatty acid degradation_Homo sapiens_hsa000710.45342430
78Ribosome_Homo sapiens_hsa030100.44660847
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44194516
80Renal cell carcinoma_Homo sapiens_hsa052110.44168033
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.43902475
82Tuberculosis_Homo sapiens_hsa051520.43794691
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43615584
84Protein digestion and absorption_Homo sapiens_hsa049740.43229093
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42451814
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41998989
87Chemical carcinogenesis_Homo sapiens_hsa052040.41627033
88Prion diseases_Homo sapiens_hsa050200.41433711
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41001246
90Sphingolipid metabolism_Homo sapiens_hsa006000.40415880
91ErbB signaling pathway_Homo sapiens_hsa040120.40006400
92Toxoplasmosis_Homo sapiens_hsa051450.39184758
93Fatty acid biosynthesis_Homo sapiens_hsa000610.38257035
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38168096
95TGF-beta signaling pathway_Homo sapiens_hsa043500.37974907
96Prolactin signaling pathway_Homo sapiens_hsa049170.36628168
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35099056
98Notch signaling pathway_Homo sapiens_hsa043300.33648307
99Melanoma_Homo sapiens_hsa052180.31488706
100Olfactory transduction_Homo sapiens_hsa047400.31378181

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