KRTAP10-7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intermediate filament organization (GO:0045109)9.10134706
2negative regulation of stress fiber assembly (GO:0051497)8.42549689
3negative regulation of actin filament bundle assembly (GO:0032232)6.65841823
4positive regulation of lamellipodium assembly (GO:0010592)5.88517250
5regulation of female receptivity (GO:0045924)5.53280647
6intermediate filament cytoskeleton organization (GO:0045104)5.21439579
7hair follicle morphogenesis (GO:0031069)5.20025658
8positive regulation of lamellipodium organization (GO:1902745)5.16772373
9intermediate filament-based process (GO:0045103)5.11209009
10regulation of mesoderm development (GO:2000380)5.01004586
11rRNA catabolic process (GO:0016075)4.96267480
12female mating behavior (GO:0060180)4.66550909
13water-soluble vitamin biosynthetic process (GO:0042364)4.46264675
14somite development (GO:0061053)4.44056504
15fatty acid elongation (GO:0030497)4.30431644
16membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.28082061
17keratinization (GO:0031424)4.17706145
18RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.12642017
19negative regulation of nitric-oxide synthase activity (GO:0051001)4.04910471
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94678705
21negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.86958955
22desmosome organization (GO:0002934)3.75598749
23membrane repolarization during action potential (GO:0086011)3.74856940
24negative regulation by host of viral transcription (GO:0043922)3.72749285
25positive regulation of glomerulus development (GO:0090193)3.72210897
26DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.61564178
27lateral sprouting from an epithelium (GO:0060601)3.61270609
28regulation of memory T cell differentiation (GO:0043380)3.58396910
29regulation of rhodopsin mediated signaling pathway (GO:0022400)3.54816707
30protein polyglutamylation (GO:0018095)3.54348765
31DNA deamination (GO:0045006)3.50182830
32regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.42568881
33negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.39614366
34regulation of heart rate by cardiac conduction (GO:0086091)3.30960680
35negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.29412718
36aggressive behavior (GO:0002118)3.28221785
37cardiac muscle cell action potential involved in contraction (GO:0086002)3.24998422
38negative regulation of DNA-templated transcription, elongation (GO:0032785)3.23553920
39phosphatidylethanolamine metabolic process (GO:0046337)3.21633771
40positive regulation of organelle assembly (GO:1902117)3.21559470
41rhodopsin mediated signaling pathway (GO:0016056)3.20739680
42phosphatidylethanolamine biosynthetic process (GO:0006646)3.18071277
43ADP metabolic process (GO:0046031)3.14788132
44cardiac muscle cell action potential (GO:0086001)3.11089359
45regulation of glomerulus development (GO:0090192)3.10427614
46cellular response to interferon-beta (GO:0035458)3.09905162
47regulation of natural killer cell differentiation (GO:0032823)3.09897119
48positive thymic T cell selection (GO:0045059)3.08294867
49regulation of defense response to virus by host (GO:0050691)3.07665326
50DNA damage response, signal transduction resulting in transcription (GO:0042772)3.06616322
51regulation of triglyceride catabolic process (GO:0010896)3.01564864
52negative regulation of monooxygenase activity (GO:0032769)3.01536537
53response to interferon-beta (GO:0035456)2.92976972
54positive regulation of natural killer cell differentiation (GO:0032825)2.92394527
55positive regulation of defense response to virus by host (GO:0002230)2.91984251
56positive regulation of T cell differentiation in thymus (GO:0033089)2.86520311
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.86489217
58multicellular organismal reproductive behavior (GO:0033057)2.85208619
59positive regulation of triglyceride biosynthetic process (GO:0010867)2.84555181
60immunoglobulin mediated immune response (GO:0016064)2.84440406
61positive regulation of potassium ion transmembrane transport (GO:1901381)2.78458506
62positive regulation of antigen processing and presentation (GO:0002579)2.72426435
63regulation of lamellipodium assembly (GO:0010591)2.72067108
64bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71415847
65organ formation (GO:0048645)2.70868573
66interferon-gamma secretion (GO:0072643)2.68744151
67NAD biosynthetic process (GO:0009435)2.67848585
68killing of cells of other organism (GO:0031640)2.64514047
69disruption of cells of other organism (GO:0044364)2.64514047
70epithelial cilium movement (GO:0003351)2.64348563
71retinol metabolic process (GO:0042572)2.62828865
72purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.61275180
73multicellular organismal signaling (GO:0035637)2.61249636
74ncRNA catabolic process (GO:0034661)2.60459477
75peptide cross-linking (GO:0018149)2.60149900
76magnesium ion transport (GO:0015693)2.59508541
77regulation of antigen processing and presentation (GO:0002577)2.58195886
78defense response to fungus (GO:0050832)2.57686044
79cardiac conduction (GO:0061337)2.57127405
80regulation of sequestering of triglyceride (GO:0010889)2.56145607
81positive regulation of T-helper 1 type immune response (GO:0002827)2.52205271
82lung-associated mesenchyme development (GO:0060484)2.51831106
83phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51518197
84phosphatidylserine acyl-chain remodeling (GO:0036150)2.51369811
85positive regulation of gamma-delta T cell activation (GO:0046645)2.50604310
86molting cycle process (GO:0022404)2.46485557
87hair cycle process (GO:0022405)2.46485557
88regulation of lamellipodium organization (GO:1902743)2.45240390
89phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.45143758
90epidermis development (GO:0008544)2.44134538
91regulation of interleukin-12 biosynthetic process (GO:0045075)2.43603632
92sulfation (GO:0051923)2.42841316
93potassium ion export (GO:0071435)2.42079730
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.41757310
95ventricular cardiac muscle cell action potential (GO:0086005)2.41618661
96transmission of nerve impulse (GO:0019226)2.41454132
97negative thymic T cell selection (GO:0045060)2.40808982
98axoneme assembly (GO:0035082)2.40160735
99molting cycle (GO:0042303)18.0429306
100hair cycle (GO:0042633)18.0429306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.21004232
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.13374917
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.67495404
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.82770435
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72591508
6VDR_22108803_ChIP-Seq_LS180_Human2.64429122
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58114168
8ERG_20517297_ChIP-Seq_VCAP_Human2.35805392
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23458723
10IGF1R_20145208_ChIP-Seq_DFB_Human2.16542468
11GBX2_23144817_ChIP-Seq_PC3_Human1.95647045
12CTCF_20526341_ChIP-Seq_ESCs_Human1.93000060
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89165134
14EZH2_22144423_ChIP-Seq_EOC_Human1.79106658
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71321929
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68015669
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65325412
18RXR_22108803_ChIP-Seq_LS180_Human1.65304335
19AR_20517297_ChIP-Seq_VCAP_Human1.64889324
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63647113
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63248036
22PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.57866974
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.55226194
24NANOG_20526341_ChIP-Seq_ESCs_Human1.52832311
25RNF2_27304074_Chip-Seq_NSC_Mouse1.49988222
26FOXH1_21741376_ChIP-Seq_ESCs_Human1.47520571
27FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47457735
28FOXA1_25329375_ChIP-Seq_VCAP_Human1.47457735
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46944341
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46809851
31TAF2_19829295_ChIP-Seq_ESCs_Human1.45451886
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.45429470
33NANOG_19829295_ChIP-Seq_ESCs_Human1.44972797
34SOX2_19829295_ChIP-Seq_ESCs_Human1.44972797
35AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44790095
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43633067
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43408283
38TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.42778875
39RUNX_20019798_ChIP-Seq_JUKART_Human1.41432011
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.38498394
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37891029
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.36820166
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.36083360
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33728986
45HTT_18923047_ChIP-ChIP_STHdh_Human1.33005966
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32689573
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.31592577
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29985307
49* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28616322
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.27144902
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26792644
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26286630
53NCOR_22424771_ChIP-Seq_293T_Human1.25958775
54ZNF274_21170338_ChIP-Seq_K562_Hela1.23702011
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22472191
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20808560
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20613357
58P300_27268052_Chip-Seq_Bcells_Human1.18621904
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.16606086
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15570171
61P53_21459846_ChIP-Seq_SAOS-2_Human1.14656690
62BCL6_27268052_Chip-Seq_Bcells_Human1.13405173
63STAT1_20625510_ChIP-Seq_HELA_Human1.11027741
64OCT1_27270436_Chip-Seq_PROSTATE_Human1.10669592
65CDX2_22108803_ChIP-Seq_LS180_Human1.09489693
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.09449860
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.09191479
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07965697
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07717899
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07524725
71FUS_26573619_Chip-Seq_HEK293_Human1.05938556
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05422644
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04821340
74OCT4_20526341_ChIP-Seq_ESCs_Human1.04789465
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04583689
76LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04002879
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03878402
78RAC3_21632823_ChIP-Seq_H3396_Human1.03723410
79SCL_19346495_ChIP-Seq_HPC-7_Human1.03241031
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.03125951
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02024042
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01284121
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00663121
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00339005
85AR_25329375_ChIP-Seq_VCAP_Human1.00238034
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99757604
87CBP_20019798_ChIP-Seq_JUKART_Human0.99757604
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98536141
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98083895
90* TP53_22573176_ChIP-Seq_HFKS_Human0.97458080
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97068967
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96125713
93GATA3_26560356_Chip-Seq_TH2_Human0.95994787
94P53_22387025_ChIP-Seq_ESCs_Mouse0.95955567
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.94678917
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94502888
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94497189
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93653224
99BCOR_27268052_Chip-Seq_Bcells_Human0.93477560
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93080669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000647_abnormal_sebaceous_gland5.14394244
2MP0002098_abnormal_vibrissa_morphology4.52169376
3MP0000383_abnormal_hair_follicle4.29383692
4MP0005646_abnormal_pituitary_gland4.09591511
5MP0004885_abnormal_endolymph3.77681605
6MP0005377_hearing/vestibular/ear_phenot3.63725264
7MP0003878_abnormal_ear_physiology3.63725264
8MP0000579_abnormal_nail_morphology3.58436396
9MP0010678_abnormal_skin_adnexa3.56881002
10MP0009780_abnormal_chondrocyte_physiolo2.80249275
11MP0005275_abnormal_skin_tensile2.79828999
12MP0009379_abnormal_foot_pigmentation2.75503504
13MP0000377_abnormal_hair_follicle2.68531675
14MP0003283_abnormal_digestive_organ2.59358804
15MP0004381_abnormal_hair_follicle2.53588901
16MP0000467_abnormal_esophagus_morphology2.46317745
17MP0003646_muscle_fatigue2.46087109
18MP0002138_abnormal_hepatobiliary_system2.35027763
19MP0000537_abnormal_urethra_morphology2.30542517
20MP0002876_abnormal_thyroid_physiology2.28713869
21MP0009053_abnormal_anal_canal2.21490023
22MP0004130_abnormal_muscle_cell2.15650830
23MP0003011_delayed_dark_adaptation2.02577367
24MP0002102_abnormal_ear_morphology2.02514724
25MP0002796_impaired_skin_barrier2.02420521
26MP0005075_abnormal_melanosome_morpholog1.99313086
27MP0000427_abnormal_hair_cycle1.95643732
28MP0002282_abnormal_trachea_morphology1.90601573
29MP0010234_abnormal_vibrissa_follicle1.83945109
30MP0001485_abnormal_pinna_reflex1.78514778
31MP0002254_reproductive_system_inflammat1.75787598
32MP0002837_dystrophic_cardiac_calcinosis1.71969251
33MP0002095_abnormal_skin_pigmentation1.63668813
34MP0001661_extended_life_span1.54159303
35MP0000367_abnormal_coat/_hair1.47039973
36MP0005174_abnormal_tail_pigmentation1.43890566
37MP0010771_integument_phenotype1.40536364
38MP0004145_abnormal_muscle_electrophysio1.35994858
39MP0001968_abnormal_touch/_nociception1.34141102
40MP0001243_abnormal_dermal_layer1.27706508
41MP0005670_abnormal_white_adipose1.26194844
42MP0004947_skin_inflammation1.24505597
43MP0000015_abnormal_ear_pigmentation1.21575303
44MP0001216_abnormal_epidermal_layer1.19706535
45MP0003137_abnormal_impulse_conducting1.18754845
46MP0003806_abnormal_nucleotide_metabolis1.18395495
47MP0002160_abnormal_reproductive_system1.15989688
48MP0004782_abnormal_surfactant_physiolog1.14518340
49MP0000569_abnormal_digit_pigmentation1.08107234
50MP0005464_abnormal_platelet_physiology1.07564341
51MP0003119_abnormal_digestive_system1.03629958
52MP0005647_abnormal_sex_gland1.01939969
53MP0005501_abnormal_skin_physiology0.98354560
54MP0002060_abnormal_skin_morphology0.97189554
55MP0000681_abnormal_thyroid_gland0.96898426
56MP0003879_abnormal_hair_cell0.96733716
57MP0005389_reproductive_system_phenotype0.96144499
58MP0000372_irregular_coat_pigmentation0.94441871
59MP0003938_abnormal_ear_development0.92718197
60MP0003453_abnormal_keratinocyte_physiol0.84042257
61MP0001919_abnormal_reproductive_system0.83587164
62MP0005000_abnormal_immune_tolerance0.79474113
63MP0002736_abnormal_nociception_after0.78634922
64MP0002139_abnormal_hepatobiliary_system0.78584644
65MP0005220_abnormal_exocrine_pancreas0.77667701
66MP0008775_abnormal_heart_ventricle0.77574257
67MP0004185_abnormal_adipocyte_glucose0.77381503
68MP0005360_urolithiasis0.75368938
69MP0009931_abnormal_skin_appearance0.74724369
70MP0003724_increased_susceptibility_to0.73378739
71MP0000613_abnormal_salivary_gland0.71475392
72MP0000685_abnormal_immune_system0.70004971
73MP0005551_abnormal_eye_electrophysiolog0.69801023
74MP0003638_abnormal_response/metabolism_0.67576678
75MP0001800_abnormal_humoral_immune0.67520826
76MP0008004_abnormal_stomach_pH0.65880461
77MP0002148_abnormal_hypersensitivity_rea0.65583447
78MP0003436_decreased_susceptibility_to0.63498968
79MP0005671_abnormal_response_to0.62135694
80MP0001835_abnormal_antigen_presentation0.60416709
81MP0006082_CNS_inflammation0.59546999
82MP0000631_abnormal_neuroendocrine_gland0.57583598
83MP0000230_abnormal_systemic_arterial0.57556222
84MP0001963_abnormal_hearing_physiology0.56184579
85MP0004134_abnormal_chest_morphology0.55301434
86MP0005503_abnormal_tendon_morphology0.55241155
87MP0001533_abnormal_skeleton_physiology0.54989817
88MP0000026_abnormal_inner_ear0.53949363
89MP0006072_abnormal_retinal_apoptosis0.52811360
90MP0008875_abnormal_xenobiotic_pharmacok0.50843256
91MP0003191_abnormal_cellular_cholesterol0.49985865
92MP0005410_abnormal_fertilization0.49240741
93MP0004215_abnormal_myocardial_fiber0.49132746
94MP0002733_abnormal_thermal_nociception0.48393817
95MP0001486_abnormal_startle_reflex0.47962138
96MP0008058_abnormal_DNA_repair0.47852248
97MP0002723_abnormal_immune_serum0.46240360
98MP0009765_abnormal_xenobiotic_induced0.44651964
99MP0003195_calcinosis0.44475640
100MP0001663_abnormal_digestive_system0.43275484

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.06827281
2Onycholysis (HP:0001806)7.20070804
3Brittle hair (HP:0002299)6.72506287
4Woolly hair (HP:0002224)6.48673548
5Abnormality of hair growth rate (HP:0011363)5.77089020
6Slow-growing hair (HP:0002217)5.77089020
7Hypotrichosis (HP:0001006)5.25532357
8Abnormal hair laboratory examination (HP:0003328)4.93203701
9Absent eyelashes (HP:0000561)4.43204383
10Absent eyebrow (HP:0002223)4.27125501
11Congenital, generalized hypertrichosis (HP:0004540)4.15817673
12Morphological abnormality of the middle ear (HP:0008609)3.82943531
13Abnormality of the proximal phalanges of the hand (HP:0009834)3.70813011
14Absent hair (HP:0002298)3.63238858
15Dry hair (HP:0011359)3.50578584
16Erythroderma (HP:0001019)3.45719210
17Bilateral microphthalmos (HP:0007633)3.45089320
18Abnormality of the nasal septum (HP:0000419)3.18042422
19Aplasia/Hypoplasia of the hallux (HP:0008362)3.02904895
20Erythema (HP:0010783)3.00631960
21Abnormality of the axillary hair (HP:0100134)2.94840813
22Abnormality of secondary sexual hair (HP:0009888)2.94840813
23Short hallux (HP:0010109)2.93065485
24Abnormality of the middle phalanges of the toes (HP:0010183)2.83372679
25Abnormality of nail color (HP:0100643)2.80963047
26Palmoplantar hyperkeratosis (HP:0000972)2.79377986
27Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.78171594
28Aplasia/Hypoplasia of the sternum (HP:0006714)2.72400068
29Ventricular fibrillation (HP:0001663)2.70817053
30Thyroid-stimulating hormone excess (HP:0002925)2.70383216
31Increased IgE level (HP:0003212)2.70103121
32Hyperthyroidism (HP:0000836)2.65947704
33Asplenia (HP:0001746)2.65232518
34Methylmalonic acidemia (HP:0002912)2.64008995
35Synostosis involving the elbow (HP:0003938)2.61203428
36Humeroradial synostosis (HP:0003041)2.61203428
37Nail dystrophy (HP:0008404)2.61059337
38Fine hair (HP:0002213)2.58871929
39Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.58772042
40Palmar hyperkeratosis (HP:0010765)2.56630534
41Aplasia/Hypoplasia of the spleen (HP:0010451)2.54404409
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53472822
43Thick nail (HP:0001805)2.51105812
44Furrowed tongue (HP:0000221)2.48088233
45Stomach cancer (HP:0012126)2.46281842
46Alopecia of scalp (HP:0002293)2.39141435
47Abnormality of the phalanges of the 5th finger (HP:0004213)2.33586098
48Hematochezia (HP:0002573)2.27470672
49Conjunctival hamartoma (HP:0100780)2.26191712
50Abnormality of the costochondral junction (HP:0000919)2.26019525
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25664291
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.25590581
53Hyperglycinemia (HP:0002154)2.22264634
54Long nose (HP:0003189)2.21505817
55Absent phalangeal crease (HP:0006109)2.20661286
56Pancreatic cysts (HP:0001737)2.14833600
57Plantar hyperkeratosis (HP:0007556)2.14074762
58Congenital stationary night blindness (HP:0007642)2.12186232
59Congenital ichthyosiform erythroderma (HP:0007431)2.08443874
60Follicular hyperkeratosis (HP:0007502)2.06777037
61Large for gestational age (HP:0001520)2.06534765
62Abolished electroretinogram (ERG) (HP:0000550)2.05782908
63Syncope (HP:0001279)2.05586293
64Decreased circulating renin level (HP:0003351)2.04108406
65Spontaneous abortion (HP:0005268)2.02367907
66Sparse eyelashes (HP:0000653)1.99978213
67Right ventricular cardiomyopathy (HP:0011663)1.97636933
68Fragile nails (HP:0001808)1.93786152
69Methylmalonic aciduria (HP:0012120)1.93196967
70Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.90955779
71Short 1st metacarpal (HP:0010034)1.90955779
72Chorioretinal atrophy (HP:0000533)1.88320702
73Nephronophthisis (HP:0000090)1.86710565
74Pendular nystagmus (HP:0012043)1.86620357
75Absent/shortened dynein arms (HP:0200106)1.85990308
76Dynein arm defect of respiratory motile cilia (HP:0012255)1.85990308
77Ketosis (HP:0001946)1.85901893
78Abnormality of the renal cortex (HP:0011035)1.84663930
79Abnormality of the columella (HP:0009929)1.84616404
80Cutaneous finger syndactyly (HP:0010554)1.84218342
81Abnormality of the prostate (HP:0008775)1.81315543
82Corneal erosion (HP:0200020)1.78677221
83Abnormality of the pupil (HP:0000615)1.75327355
84Abnormal finger flexion creases (HP:0006143)1.72993901
85Short femoral neck (HP:0100864)1.71895129
86Small epiphyses (HP:0010585)1.71113538
87Abnormality of the distal phalanges of the toes (HP:0010182)1.70632542
88Lipid accumulation in hepatocytes (HP:0006561)1.69861284
89Renal cortical cysts (HP:0000803)1.69602971
90Short phalanx of the thumb (HP:0009660)1.69071826
91Abnormality of the 1st metacarpal (HP:0010009)1.68830463
92Keratoconus (HP:0000563)1.68695526
93Increased corneal curvature (HP:0100692)1.68695526
94Attenuation of retinal blood vessels (HP:0007843)1.68468609
95Increased hepatocellular lipid droplets (HP:0006565)1.65759263
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.65595560
97Hyperalaninemia (HP:0003348)1.65279058
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65279058
99Abnormality of alanine metabolism (HP:0010916)1.65279058
100Keratoconjunctivitis (HP:0001096)1.64033325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.66018500
2ZAK3.28903240
3ITK3.25099619
4STK163.19241428
5TLK13.11590958
6GRK13.10994631
7ADRBK23.06028318
8EIF2AK32.80700856
9KDR2.72036196
10TEC2.71753112
11KIT2.43714171
12IKBKE2.28873853
13GRK72.20119425
14CAMKK21.82947743
15PDK21.80842909
16RIPK41.73223742
17MAPKAPK31.69044112
18PHKG21.67261498
19PHKG11.67261498
20BTK1.62848942
21NUAK11.58844715
22TAOK31.54985044
23TESK21.53401909
24BCKDK1.31854350
25MST41.30430004
26CAMKK11.29928851
27RPS6KA51.28558367
28PRKCQ1.25178769
29SYK1.24486489
30ADRBK11.20030122
31CSF1R1.19166421
32ABL11.18057771
33FGFR21.17971033
34MAP4K21.12235031
35IKBKB1.12077385
36TXK1.10174651
37VRK11.06998911
38MAP2K61.05578780
39RPS6KA61.05110034
40MAP4K11.03782079
41MAP3K91.02536402
42OXSR10.93596856
43LYN0.93136686
44PASK0.91232797
45HCK0.90296280
46PLK20.87180369
47FES0.84935102
48INSRR0.84791888
49GRK50.80181381
50PLK40.80048593
51LCK0.77008696
52MAPK70.76394918
53BMPR20.75696581
54MAPK30.75690559
55PIM10.74926810
56TIE10.72337023
57MAP2K20.71532910
58DAPK20.70768292
59BRSK20.70576638
60STK390.69821375
61RPS6KC10.68691164
62RPS6KL10.68691164
63PDK10.68652537
64FLT30.67799069
65MAPK150.66755016
66NME10.66413662
67PINK10.65851870
68MAPK130.64827056
69CDK30.63149795
70WNK40.62523890
71RPS6KA20.62327296
72TGFBR10.61110514
73TBK10.60169323
74PIK3CA0.59185817
75STK100.58243763
76PIK3CG0.56893078
77MAPKAPK50.52886783
78GRK60.52262181
79VRK20.50055783
80TRPM70.48813021
81CSNK1A10.47539650
82DAPK10.47125982
83PIM20.46220838
84FER0.46187280
85BMPR1B0.45236974
86MAP3K50.44397092
87IGF1R0.41812488
88STK110.40299520
89MKNK10.39387659
90CSNK1G10.39229897
91WEE10.38158940
92CSNK2A10.37162489
93OBSCN0.36753264
94PRKCA0.36217284
95GSK3A0.35385043
96CSNK1G30.35096754
97RPS6KA10.33308329
98PRKACA0.32458532
99MOS0.31643592
100MAPK10.30947470

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.87222173
2Allograft rejection_Homo sapiens_hsa053303.39257658
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.27906231
4Graft-versus-host disease_Homo sapiens_hsa053323.23718418
5Autoimmune thyroid disease_Homo sapiens_hsa053203.12903452
6Type I diabetes mellitus_Homo sapiens_hsa049402.98624773
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66632660
8Fatty acid elongation_Homo sapiens_hsa000622.35928731
9Nitrogen metabolism_Homo sapiens_hsa009102.28796666
10Linoleic acid metabolism_Homo sapiens_hsa005912.28706919
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.27413166
12Glycerolipid metabolism_Homo sapiens_hsa005612.27248436
13Phototransduction_Homo sapiens_hsa047442.25408611
14Staphylococcus aureus infection_Homo sapiens_hsa051502.21695512
15Antigen processing and presentation_Homo sapiens_hsa046121.87570947
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80236406
17Rheumatoid arthritis_Homo sapiens_hsa053231.67370128
18Other glycan degradation_Homo sapiens_hsa005111.66693995
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64619738
20p53 signaling pathway_Homo sapiens_hsa041151.61675256
21Vitamin digestion and absorption_Homo sapiens_hsa049771.58043577
22Primary immunodeficiency_Homo sapiens_hsa053401.53665939
23Retinol metabolism_Homo sapiens_hsa008301.48202003
24Homologous recombination_Homo sapiens_hsa034401.45422710
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45195059
26Arachidonic acid metabolism_Homo sapiens_hsa005901.43251494
27Sulfur metabolism_Homo sapiens_hsa009201.41239515
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36928557
29Butanoate metabolism_Homo sapiens_hsa006501.34745999
30Fat digestion and absorption_Homo sapiens_hsa049751.32069318
31Fatty acid biosynthesis_Homo sapiens_hsa000611.31082091
32RNA degradation_Homo sapiens_hsa030181.30125551
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28210836
34Leishmaniasis_Homo sapiens_hsa051401.26777994
35Viral myocarditis_Homo sapiens_hsa054161.23572109
36Salivary secretion_Homo sapiens_hsa049701.20345051
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19451279
38Histidine metabolism_Homo sapiens_hsa003401.18973381
39Systemic lupus erythematosus_Homo sapiens_hsa053221.17296570
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11114245
41Hematopoietic cell lineage_Homo sapiens_hsa046401.04390375
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01885772
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00992226
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96621618
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.96438601
46Ether lipid metabolism_Homo sapiens_hsa005650.96206661
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92010493
48Tryptophan metabolism_Homo sapiens_hsa003800.85668185
49Caffeine metabolism_Homo sapiens_hsa002320.85540861
50Chemical carcinogenesis_Homo sapiens_hsa052040.83003966
51Taste transduction_Homo sapiens_hsa047420.82602862
52Circadian entrainment_Homo sapiens_hsa047130.80291398
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80170156
54Olfactory transduction_Homo sapiens_hsa047400.73340218
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.72953432
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.70076025
57Peroxisome_Homo sapiens_hsa041460.68591688
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68398539
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66459407
60Morphine addiction_Homo sapiens_hsa050320.65890122
61Gastric acid secretion_Homo sapiens_hsa049710.65824806
62beta-Alanine metabolism_Homo sapiens_hsa004100.64949720
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61455829
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.60858615
65Fatty acid metabolism_Homo sapiens_hsa012120.59818736
66Serotonergic synapse_Homo sapiens_hsa047260.57204765
67Dorso-ventral axis formation_Homo sapiens_hsa043200.57171190
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.56002602
69Nicotine addiction_Homo sapiens_hsa050330.54898752
70Herpes simplex infection_Homo sapiens_hsa051680.54502581
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53197628
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51130751
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48816779
74Pertussis_Homo sapiens_hsa051330.43210572
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43115710
76ABC transporters_Homo sapiens_hsa020100.41995887
77Regulation of autophagy_Homo sapiens_hsa041400.41758649
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40573402
79Proteasome_Homo sapiens_hsa030500.38540976
80Ovarian steroidogenesis_Homo sapiens_hsa049130.36308759
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35115391
82Malaria_Homo sapiens_hsa051440.34770474
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33522862
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.32601557
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31096688
86Tuberculosis_Homo sapiens_hsa051520.30482239
87Renin secretion_Homo sapiens_hsa049240.30291985
88Cardiac muscle contraction_Homo sapiens_hsa042600.30061150
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.26547802
90Type II diabetes mellitus_Homo sapiens_hsa049300.26351295
91Choline metabolism in cancer_Homo sapiens_hsa052310.26307613
92Pancreatic secretion_Homo sapiens_hsa049720.25727469
93Calcium signaling pathway_Homo sapiens_hsa040200.25690325
94Oxidative phosphorylation_Homo sapiens_hsa001900.24131933
95Purine metabolism_Homo sapiens_hsa002300.23687369
96Shigellosis_Homo sapiens_hsa051310.22702168
97PPAR signaling pathway_Homo sapiens_hsa033200.22251081
98Starch and sucrose metabolism_Homo sapiens_hsa005000.21981221
99Toxoplasmosis_Homo sapiens_hsa051450.21903007
100Mineral absorption_Homo sapiens_hsa049780.21524174

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