ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	9.99980211
2	adhesion of symbiont to host cell (GO:0044650)	9.76711310
3	virion attachment to host cell (GO:0019062)	9.76711310
4	citrulline biosynthetic process (GO:0019240)	8.95212079
5	hair follicle morphogenesis (GO:0031069)	8.40040406
6	peptide cross-linking (GO:0018149)	8.38062483
7	adhesion of symbiont to host (GO:0044406)	8.23722317
8	intermediate filament cytoskeleton organization (GO:0045104)	6.63359962
9	intermediate filament-based process (GO:0045103)	6.42140026
10	cell wall macromolecule metabolic process (GO:0044036)	6.30170841
11	cell wall macromolecule catabolic process (GO:0016998)	6.30170841
12	epidermis development (GO:0008544)	6.18051260
13	citrulline metabolic process (GO:0000052)	5.91828757
14	keratinocyte differentiation (GO:0030216)	5.70428118
15	establishment of skin barrier (GO:0061436)	5.60735717
16	molting cycle process (GO:0022404)	5.40146936
17	hair cycle process (GO:0022405)	5.40146936
18	regulation of water loss via skin (GO:0033561)	4.98894108
19	peptidyl-arginine modification (GO:0018195)	4.95767228
20	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.92619537
21	skin morphogenesis (GO:0043589)	4.71159454
22	hemidesmosome assembly (GO:0031581)	4.67614434
23	epidermal cell differentiation (GO:0009913)	4.46304815
24	hair cycle (GO:0042633)	34.9418275
25	molting cycle (GO:0042303)	34.9418275
26	tooth mineralization (GO:0034505)	3.92704920
27	keratinocyte development (GO:0003334)	3.87762623
28	regulation of keratinocyte differentiation (GO:0045616)	3.37896834
29	multicellular organismal water homeostasis (GO:0050891)	3.35894578
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.35070787
31	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.33940924
32	positive regulation of hair follicle development (GO:0051798)	3.27549538
33	positive regulation of hair cycle (GO:0042635)	3.27549538
34	hair follicle development (GO:0001942)	3.18569845
35	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.11139484
36	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.05645212
37	regulation of hair follicle development (GO:0051797)	3.04618106
38	bone trabecula formation (GO:0060346)	2.96335258
39	epithelium development (GO:0060429)	2.92809977
40	positive regulation of meiotic cell cycle (GO:0051446)	2.83827085
41	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.82207240
42	gap junction assembly (GO:0016264)	2.81856794
43	water homeostasis (GO:0030104)	2.75270789
44	positive regulation of epidermis development (GO:0045684)	2.72593110
45	regulation of hair cycle (GO:0042634)	2.72132566
46	regulation of epidermal cell differentiation (GO:0045604)	2.61597968
47	fatty acid elongation (GO:0030497)	2.59451018
48	negative regulation of protein localization to plasma membrane (GO:1903077)	2.57267435
49	ectoderm development (GO:0007398)	2.54224980
50	atrioventricular valve morphogenesis (GO:0003181)	2.53904560
51	regulation of epidermis development (GO:0045682)	2.50556295
52	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.50314288
53	phosphatidylserine metabolic process (GO:0006658)	2.32434648
54	ventricular cardiac muscle cell action potential (GO:0086005)	2.29653399
55	wound healing, spreading of epidermal cells (GO:0035313)	2.26844331
56	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.25547759
57	positive regulation of monocyte chemotaxis (GO:0090026)	2.25042627
58	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.23545526
59	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.23492682
60	negative regulation of cell fate specification (GO:0009996)	2.23158495
61	positive regulation of epidermal cell differentiation (GO:0045606)	2.22385853
62	cranial suture morphogenesis (GO:0060363)	2.20471188
63	lymph vessel development (GO:0001945)	2.16513716
64	skin development (GO:0043588)	2.08966308
65	regulation of ruffle assembly (GO:1900027)	2.06603767
66	aging (GO:0007568)	2.05338105
67	myotube differentiation (GO:0014902)	2.04056774
68	negative regulation of epidermis development (GO:0045683)	2.03710402
69	intermediate filament organization (GO:0045109)	12.0739931
70	keratinization (GO:0031424)	11.5896428
71	outflow tract septum morphogenesis (GO:0003148)	1.99097096
72	epithelial cell-cell adhesion (GO:0090136)	1.97655432
73	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.97581321
74	regulation of cardioblast differentiation (GO:0051890)	1.96818468
75	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.92710994
76	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.91613173
77	regulation of heart rate by cardiac conduction (GO:0086091)	1.90919546
78	regulation of keratinocyte proliferation (GO:0010837)	1.88696491
79	ephrin receptor signaling pathway (GO:0048013)	1.87823645
80	cell communication involved in cardiac conduction (GO:0086065)	1.82292000
81	non-canonical Wnt signaling pathway (GO:0035567)	1.80224096
82	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.79848191
83	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.76171067
84	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.73790288
85	cell-substrate junction assembly (GO:0007044)	1.73705592
86	alditol phosphate metabolic process (GO:0052646)	1.71494944
87	primary alcohol catabolic process (GO:0034310)	1.68696898
88	very long-chain fatty acid metabolic process (GO:0000038)	1.65100919
89	negative regulation of epidermal cell differentiation (GO:0045605)	1.65090109
90	coronary vasculature morphogenesis (GO:0060977)	1.64605859
91	regulation of cardioblast proliferation (GO:0003264)	1.62306067
92	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.62306067
93	regulation of monocyte chemotaxis (GO:0090025)	1.61307789
94	cardiac right ventricle morphogenesis (GO:0003215)	1.60714184
95	wound healing, spreading of cells (GO:0044319)	1.58872310
96	establishment of planar polarity (GO:0001736)	1.58422127
97	establishment of tissue polarity (GO:0007164)	1.58422127
98	craniofacial suture morphogenesis (GO:0097094)	1.58073092
99	cellular modified amino acid biosynthetic process (GO:0042398)	1.56832828
100	response to UV-B (GO:0010224)	1.56780577

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.65612496
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.06125684
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.59240572
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.66721254
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.39615566
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.13843490
7	* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.01694893
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.4193686
9	TAF2_19829295_ChIP-Seq_ESCs_Human	1.85850711
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.85293543
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.85273707
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.77821683
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.76948097
14	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.75662532
15	NANOG_20526341_ChIP-Seq_ESCs_Human	1.72871352
16	EGR1_19032775_ChIP-ChIP_M12_Human	1.71905406
17	ERG_20517297_ChIP-Seq_VCAP_Human	1.68511411
18	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.68470213
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.63618231
20	P53_21459846_ChIP-Seq_SAOS-2_Human	1.62950002
21	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.56637232
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.54808980
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.53221144
24	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.52763233
25	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.52040959
26	LXR_22292898_ChIP-Seq_THP-1_Human	1.51344469
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.50180736
28	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49496311
29	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.46516415
30	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.46516415
31	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.45078452
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.44370022
33	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.38796653
34	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.38145922
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.37681206
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36176616
37	ATF3_27146783_Chip-Seq_COLON_Human	1.35733847
38	PHF8_20622854_ChIP-Seq_HELA_Human	1.29425351
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28216716
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.26830185
41	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.26109285
42	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.25545904
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25236470
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24635818
45	P68_20966046_ChIP-Seq_HELA_Human	1.24053264
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23136693
47	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20918445
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.19990960
49	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19653444
50	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.19618684
51	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16477628
52	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.16388638
53	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.15785203
54	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.14063296
55	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.09685900
56	SMC4_20622854_ChIP-Seq_HELA_Human	1.08816898
57	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08554596
58	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06355970
59	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06189335
60	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.05820153
61	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05339513
62	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.05179094
63	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04806102
64	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.02269695
65	SPI1_20517297_ChIP-Seq_HL60_Human	1.01356363
66	* TP63_23658742_ChIP-Seq_EP156T_Human	1.01294029
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00175574
68	* E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.99252419
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98245681
70	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97874683
71	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97351529
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96050369
73	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95965176
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95907712
75	* RAC3_21632823_ChIP-Seq_H3396_Human	0.95571387
76	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94682528
77	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93592297
78	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.92441834
79	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91064202
80	* SOX2_21211035_ChIP-Seq_LN229_Human	0.91018008
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89573869
82	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.87845341
83	RXR_22108803_ChIP-Seq_LS180_Human	0.86649653
84	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86341471
85	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.82472738
86	ZNF263_19887448_ChIP-Seq_K562_Human	0.81677632
87	SOX2_20726797_ChIP-Seq_SW620_Human	0.81591883
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80880673
89	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.79483562
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.79131634
91	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.79040694
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.77669580
93	* RING1B_27294783_Chip-Seq_ESCs_Mouse	0.76058350
94	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.75732320
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.75619421
96	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.75017603
97	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74080382
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.73674107
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.73255641
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.73255641

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.47655211
2	MP0002098_abnormal_vibrissa_morphology	7.33820818
3	MP0000647_abnormal_sebaceous_gland	6.54161546
4	MP0002796_impaired_skin_barrier	5.93417941
5	MP0010234_abnormal_vibrissa_follicle	5.19597323
6	MP0005275_abnormal_skin_tensile	5.08866553
7	MP0000383_abnormal_hair_follicle	4.48605273
8	MP0000377_abnormal_hair_follicle	4.10594973
9	MP0010678_abnormal_skin_adnexa	3.99463388
10	MP0003705_abnormal_hypodermis_morpholog	3.73320353
11	MP0005501_abnormal_skin_physiology	3.70679539
12	MP0000427_abnormal_hair_cycle	3.49259977
13	MP0002254_reproductive_system_inflammat	3.15499536
14	MP0001216_abnormal_epidermal_layer	2.65418944
15	MP0004381_abnormal_hair_follicle	2.43534225
16	MP0000367_abnormal_coat/_hair	2.40464130
17	MP0010771_integument_phenotype	2.30111272
18	MP0004947_skin_inflammation	2.26148823
19	MP0002060_abnormal_skin_morphology	2.18086526
20	MP0001243_abnormal_dermal_layer	2.16153970
21	MP0003453_abnormal_keratinocyte_physiol	2.15179998
22	MP0002234_abnormal_pharynx_morphology	2.04851475
23	MP0000467_abnormal_esophagus_morphology	1.65818459
24	MP0009053_abnormal_anal_canal	1.54793314
25	MP0009931_abnormal_skin_appearance	1.50536226
26	MP0000762_abnormal_tongue_morphology	1.46299711
27	MP0003566_abnormal_cell_adhesion	1.43044362
28	MP0003941_abnormal_skin_development	1.20687656
29	MP0005409_darkened_coat_color	1.11768488
30	MP0004885_abnormal_endolymph	0.99666570
31	MP0001191_abnormal_skin_condition	0.98826540
32	MP0004185_abnormal_adipocyte_glucose	0.96219354
33	MP0004264_abnormal_extraembryonic_tissu	0.90212281
34	MP0001851_eye_inflammation	0.76046383
35	MP0002095_abnormal_skin_pigmentation	0.75148285
36	MP0003315_abnormal_perineum_morphology	0.70881880
37	MP0008438_abnormal_cutaneous_collagen	0.69406225
38	MP0001346_abnormal_lacrimal_gland	0.67357535
39	MP0001340_abnormal_eyelid_morphology	0.65037665
40	MP0002877_abnormal_melanocyte_morpholog	0.64889557
41	MP0001849_ear_inflammation	0.64575366
42	MP0010030_abnormal_orbit_morphology	0.63437319
43	MP0000566_synostosis	0.60741844
44	MP0000627_abnormal_mammary_gland	0.57550214
45	MP0001661_extended_life_span	0.53761207
46	MP0003191_abnormal_cellular_cholesterol	0.52884115
47	MP0002282_abnormal_trachea_morphology	0.49415794
48	MP0003755_abnormal_palate_morphology	0.48421976
49	MP0005451_abnormal_body_composition	0.47964346
50	MP0005023_abnormal_wound_healing	0.47054000
51	MP0002970_abnormal_white_adipose	0.46773840
52	MP0001784_abnormal_fluid_regulation	0.44824367
53	MP0002111_abnormal_tail_morphology	0.41147553
54	MP0002249_abnormal_larynx_morphology	0.40275100
55	MP0010352_gastrointestinal_tract_polyps	0.35112937
56	MP0000678_abnormal_parathyroid_gland	0.34512356
57	MP0009840_abnormal_foam_cell	0.33126614
58	MP0005075_abnormal_melanosome_morpholog	0.32988157
59	MP0003385_abnormal_body_wall	0.32762002
60	MP0000537_abnormal_urethra_morphology	0.32269745
61	MP0004272_abnormal_basement_membrane	0.32263647
62	MP0002177_abnormal_outer_ear	0.26940913
63	MP0003329_amyloid_beta_deposits	0.26664088
64	MP0003763_abnormal_thymus_physiology	0.26062878
65	MP0003950_abnormal_plasma_membrane	0.25830499
66	MP0000465_gastrointestinal_hemorrhage	0.23749328
67	MP0002697_abnormal_eye_size	0.22978131
68	MP0005248_abnormal_Harderian_gland	0.22803419
69	MP0004019_abnormal_vitamin_homeostasis	0.20044638
70	MP0006054_spinal_hemorrhage	0.19471997
71	MP0003300_gastrointestinal_ulcer	0.19451555
72	MP0005666_abnormal_adipose_tissue	0.18290230
73	MP0000432_abnormal_head_morphology	0.17704262
74	MP0003638_abnormal_response/metabolism_	0.16573277
75	MP0001879_abnormal_lymphatic_vessel	0.15996037
76	MP0004742_abnormal_vestibular_system	0.15715152
77	MP0003935_abnormal_craniofacial_develop	0.15550605
78	MP0005375_adipose_tissue_phenotype	0.15507969
79	MP0003448_altered_tumor_morphology	0.14900427
80	MP0000751_myopathy	0.14564751
81	MP0000604_amyloidosis	0.14476412
82	MP0004858_abnormal_nervous_system	0.14034827
83	MP0005367_renal/urinary_system_phenotyp	0.13418783
84	MP0000516_abnormal_urinary_system	0.13418783
85	MP0003011_delayed_dark_adaptation	0.11687626
86	MP0003075_altered_response_to	0.11103282
87	MP0005076_abnormal_cell_differentiation	0.10721476
88	MP0000733_abnormal_muscle_development	0.10120421
89	MP0002233_abnormal_nose_morphology	0.09345293
90	MP0003045_fibrosis	0.09034043
91	MP0002166_altered_tumor_susceptibility	0.08911821
92	MP0002006_tumorigenesis	0.08772420
93	MP0009379_abnormal_foot_pigmentation	0.08504586
94	MP0006138_congestive_heart_failure	0.08078290
95	MP0009384_cardiac_valve_regurgitation	0.07788742
96	MP0000750_abnormal_muscle_regeneration	0.07766871
97	MP0000013_abnormal_adipose_tissue	0.07539539
98	MP0005193_abnormal_anterior_eye	0.07217934
99	MP0001958_emphysema	0.06234062
100	MP0008569_lethality_at_weaning	0.06209312

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.76151043
2	Nail dystrophy (HP:0008404)	7.52063975
3	Abnormality of nail color (HP:0100643)	5.81183266
4	Abnormal hair laboratory examination (HP:0003328)	5.53549260
5	Fragile nails (HP:0001808)	5.52380754
6	Fine hair (HP:0002213)	5.42583991
7	Alopecia of scalp (HP:0002293)	4.66285327
8	Palmoplantar hyperkeratosis (HP:0000972)	4.61312611
9	Onycholysis (HP:0001806)	4.59903428
10	Palmar hyperkeratosis (HP:0010765)	4.33690297
11	Increased IgE level (HP:0003212)	4.33068490
12	Plantar hyperkeratosis (HP:0007556)	4.21022855
13	Thick nail (HP:0001805)	4.14887292
14	Right ventricular cardiomyopathy (HP:0011663)	4.07259001
15	Follicular hyperkeratosis (HP:0007502)	3.88853401
16	Sparse eyelashes (HP:0000653)	3.45179796
17	Erythema (HP:0010783)	3.39508616
18	Abnormality of the frontal sinuses (HP:0002687)	3.19987865
19	Oral leukoplakia (HP:0002745)	3.15847127
20	Amelogenesis imperfecta (HP:0000705)	3.12146893
21	Parakeratosis (HP:0001036)	3.03096213
22	Milia (HP:0001056)	3.01400804
23	Erythroderma (HP:0001019)	2.92630731
24	Curly hair (HP:0002212)	2.70044017
25	Intention tremor (HP:0002080)	2.57668217
26	Ridged nail (HP:0001807)	2.56201430
27	Neck muscle weakness (HP:0000467)	2.52578268
28	Congenital, generalized hypertrichosis (HP:0004540)	2.51560596
29	Aplasia cutis congenita (HP:0001057)	2.49548552
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.47030948
31	Dry hair (HP:0011359)	2.42588422
32	Torticollis (HP:0000473)	2.30731799
33	Natal tooth (HP:0000695)	2.27402908
34	Abnormal blistering of the skin (HP:0008066)	2.24177873
35	Advanced eruption of teeth (HP:0006288)	2.20063614
36	Corneal erosion (HP:0200020)	2.07545199
37	Hypohidrosis (HP:0000966)	2.06515528
38	Hypotrichosis (HP:0001006)	15.2237789
39	Abnormality of hair growth rate (HP:0011363)	11.5224010
40	Slow-growing hair (HP:0002217)	11.5224010
41	Woolly hair (HP:0002224)	11.0236382
42	Brittle hair (HP:0002299)	10.7582272
43	Ventricular tachycardia (HP:0004756)	1.97216016
44	Palmoplantar keratoderma (HP:0000982)	1.96613394
45	Craniofacial dystonia (HP:0012179)	1.95406459
46	Concave nail (HP:0001598)	1.89154304
47	Difficulty walking (HP:0002355)	1.89026635
48	Pruritus (HP:0000989)	1.85839324
49	Abnormality of the pupil (HP:0000615)	1.84151470
50	Abnormality of dental color (HP:0011073)	1.81843549
51	Abnormality of the parietal bone (HP:0002696)	1.80721987
52	Abnormality of the dental root (HP:0006486)	1.80642212
53	Taurodontia (HP:0000679)	1.80642212
54	Abnormality of permanent molar morphology (HP:0011071)	1.80642212
55	Focal dystonia (HP:0004373)	1.78745114
56	Abnormality of molar (HP:0011077)	1.76890703
57	Abnormality of molar morphology (HP:0011070)	1.76890703
58	Widely patent fontanelles and sutures (HP:0004492)	1.74622389
59	Hyporeflexia of lower limbs (HP:0002600)	1.71582452
60	Ventricular fibrillation (HP:0001663)	1.70668496
61	Absent eyelashes (HP:0000561)	1.64612752
62	Recurrent corneal erosions (HP:0000495)	1.62483327
63	Conjunctival hamartoma (HP:0100780)	1.60056196
64	Abnormality of the dental pulp (HP:0006479)	1.59208999
65	Fatigable weakness (HP:0003473)	1.52100233
66	Abnormality of the neuromuscular junction (HP:0003398)	1.52100233
67	Sudden death (HP:0001699)	1.51064782
68	Blepharitis (HP:0000498)	1.50273746
69	Unilateral renal agenesis (HP:0000122)	1.50202217
70	Abnormality of placental membranes (HP:0011409)	1.49311403
71	Amniotic constriction ring (HP:0009775)	1.49311403
72	Abnormality of the aortic arch (HP:0012303)	1.47161164
73	Round ear (HP:0100830)	1.46869186
74	Acanthosis nigricans (HP:0000956)	1.46452858
75	Heterogeneous (HP:0001425)	1.46285260
76	Distal lower limb muscle weakness (HP:0009053)	1.43124634
77	Lip pit (HP:0100267)	1.41890627
78	Achilles tendon contracture (HP:0001771)	1.38277100
79	Keratoconjunctivitis sicca (HP:0001097)	1.37727524
80	Carious teeth (HP:0000670)	1.33281565
81	Craniofacial hyperostosis (HP:0004493)	1.33242651
82	Autoamputation (HP:0001218)	1.32731905
83	Gangrene (HP:0100758)	1.31710695
84	Abnormality of the Achilles tendon (HP:0005109)	1.30268634
85	Ectropion (HP:0000656)	1.30211390
86	Type 1 muscle fiber predominance (HP:0003803)	1.26615536
87	Variable expressivity (HP:0003828)	1.25575954
88	Hypergammaglobulinemia (HP:0010702)	1.25337228
89	Anonychia (HP:0001798)	1.23250982
90	Abnormality of the fingernails (HP:0001231)	1.21989208
91	Keratoconjunctivitis (HP:0001096)	1.20996581
92	Neonatal onset (HP:0003623)	1.19921329
93	Widely spaced teeth (HP:0000687)	1.18270162
94	Increased connective tissue (HP:0009025)	1.17236189
95	Selective tooth agenesis (HP:0001592)	1.16829368
96	Distal arthrogryposis (HP:0005684)	1.14743543
97	Lack of skin elasticity (HP:0100679)	1.14620047
98	Sparse scalp hair (HP:0002209)	1.11860519
99	Bronchomalacia (HP:0002780)	1.11455068
100	Wide cranial sutures (HP:0010537)	1.10250921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.40057013
2	MAPKAPK3	4.24224758
3	FER	3.93195839
4	ERN1	3.87407941
5	MAP3K6	3.49965454
6	EPHB2	3.16121925
7	TAOK1	3.04561716
8	MAP3K3	2.84607417
9	TRIB3	2.69822292
10	LATS1	2.39897641
11	MAP3K2	2.38882940
12	PIK3CG	2.13947089
13	MAP3K11	2.08031343
14	RPS6KB2	2.05160001
15	TTN	2.01649124
16	MAP2K6	1.80048139
17	EEF2K	1.74986799
18	LATS2	1.63599865
19	EPHB1	1.60757941
20	NME1	1.57417741
21	BCR	1.34015192
22	MAP3K1	1.29942284
23	FGFR2	1.28638631
24	KSR2	1.25345172
25	MAP2K3	1.24549068
26	RIPK1	1.20857389
27	FGFR4	1.19327687
28	BMX	1.17376414
29	PKN2	1.15280530
30	CDK6	1.14585661
31	MST1R	1.14412573
32	BLK	1.13447153
33	PBK	1.07103006
34	MAPKAPK2	1.06803990
35	LRRK2	1.06315771
36	FGFR1	1.03190165
37	MAP3K7	0.99854489
38	FGFR3	0.96965156
39	PTK6	0.96904219
40	PDGFRA	0.96399680
41	MAP2K4	0.85819153
42	MAP3K9	0.84810851
43	SIK1	0.83943111
44	RPS6KA4	0.80850833
45	MAP2K1	0.80360557
46	PIM2	0.78063835
47	STK38	0.77622604
48	PTK2	0.76607923
49	CDK19	0.73021742
50	OBSCN	0.72686251
51	STK38L	0.71853510
52	DYRK1B	0.71412742
53	PRKD1	0.70870850
54	TESK1	0.70827550
55	PAK4	0.69802157
56	PAK3	0.67897389
57	DDR2	0.65613384
58	MET	0.64312569
59	NEK1	0.57432524
60	PRKCI	0.57295976
61	ERBB4	0.56957110
62	MAP3K5	0.55912801
63	TRPM7	0.53623366
64	TGFBR1	0.52717672
65	NTRK2	0.52468663
66	TYRO3	0.51606329
67	PRKCH	0.51208928
68	MAP3K10	0.50765070
69	RET	0.49596567
70	PAK6	0.49072569
71	ALK	0.47414994
72	MAPK12	0.46485993
73	ERBB2	0.44750517
74	PHKG1	0.44245669
75	PHKG2	0.44245669
76	PAK2	0.44041627
77	RPS6KA1	0.43163599
78	JAK1	0.42495827
79	GSK3A	0.42329003
80	MAP2K2	0.41536490
81	CSNK1E	0.39898038
82	MST4	0.39863968
83	ERBB3	0.38054217
84	ILK	0.37287099
85	EPHA3	0.37255665
86	TYK2	0.36433107
87	LIMK1	0.36078254
88	JAK2	0.35408535
89	GRK6	0.30101649
90	MAP3K8	0.29334013
91	FYN	0.27235034
92	CSNK1A1	0.24308486
93	ROCK2	0.23600259
94	SRC	0.23484582
95	PRKACA	0.22041225
96	PRKACG	0.21682587
97	CLK1	0.21676555
98	HCK	0.21675475
99	CSNK1D	0.21355172
100	STK11	0.20781207

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.85349375
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.82004357
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.13968781
4	Fatty acid elongation_Homo sapiens_hsa00062	2.79481561
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.53799887
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.20489481
7	Phenylalanine metabolism_Homo sapiens_hsa00360	1.86052484
8	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.85153184
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.77196286
10	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.76844792
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.73253314
12	Melanogenesis_Homo sapiens_hsa04916	1.59517695
13	Axon guidance_Homo sapiens_hsa04360	1.52759409
14	Histidine metabolism_Homo sapiens_hsa00340	1.40566489
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37778807
16	Bladder cancer_Homo sapiens_hsa05219	1.35967911
17	Glioma_Homo sapiens_hsa05214	1.33578657
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.31377035
19	Caffeine metabolism_Homo sapiens_hsa00232	1.31230646
20	Thyroid cancer_Homo sapiens_hsa05216	1.30899163
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.26925072
22	GnRH signaling pathway_Homo sapiens_hsa04912	1.24024314
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.22604111
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.16497500
25	Tight junction_Homo sapiens_hsa04530	1.15739563
26	Acute myeloid leukemia_Homo sapiens_hsa05221	1.14066776
27	Pancreatic secretion_Homo sapiens_hsa04972	1.11191077
28	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.06867393
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.05811990
30	Mineral absorption_Homo sapiens_hsa04978	1.05389129
31	Long-term potentiation_Homo sapiens_hsa04720	1.04198606
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04048012
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02142992
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.96661219
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.92432226
36	Adherens junction_Homo sapiens_hsa04520	0.91237039
37	Tyrosine metabolism_Homo sapiens_hsa00350	0.90584624
38	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.90344011
39	Steroid biosynthesis_Homo sapiens_hsa00100	0.89515401
40	Pertussis_Homo sapiens_hsa05133	0.88315369
41	ECM-receptor interaction_Homo sapiens_hsa04512	0.86876132
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.86347521
43	Endometrial cancer_Homo sapiens_hsa05213	0.84376216
44	Long-term depression_Homo sapiens_hsa04730	0.83635513
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82317553
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81816664
47	Ras signaling pathway_Homo sapiens_hsa04014	0.81161113
48	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.79890869
49	Wnt signaling pathway_Homo sapiens_hsa04310	0.76150979
50	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76111299
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74537126
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.74483734
53	Amoebiasis_Homo sapiens_hsa05146	0.73408740
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.72580952
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71214674
56	Gastric acid secretion_Homo sapiens_hsa04971	0.69893190
57	Renin secretion_Homo sapiens_hsa04924	0.68139972
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.67098361
59	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64353040
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.64342055
61	Phototransduction_Homo sapiens_hsa04744	0.61874507
62	Insulin resistance_Homo sapiens_hsa04931	0.60049839
63	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.59156791
64	MicroRNAs in cancer_Homo sapiens_hsa05206	0.58789394
65	Hepatitis C_Homo sapiens_hsa05160	0.55745012
66	Gap junction_Homo sapiens_hsa04540	0.55218990
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55094932
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.54316388
69	Salmonella infection_Homo sapiens_hsa05132	0.53531482
70	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53330916
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51344608
72	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51018393
73	Butanoate metabolism_Homo sapiens_hsa00650	0.50379191
74	Fatty acid degradation_Homo sapiens_hsa00071	0.49616993
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49097566
76	Renal cell carcinoma_Homo sapiens_hsa05211	0.48359287
77	Salivary secretion_Homo sapiens_hsa04970	0.47494658
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.47180174
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.46818572
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.46813140
81	Focal adhesion_Homo sapiens_hsa04510	0.46758812
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46400220
83	Platelet activation_Homo sapiens_hsa04611	0.46051366
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44515469
85	ErbB signaling pathway_Homo sapiens_hsa04012	0.44406880
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44139503
87	Prion diseases_Homo sapiens_hsa05020	0.42529474
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.41141290
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40984668
90	Olfactory transduction_Homo sapiens_hsa04740	0.38550025
91	Tuberculosis_Homo sapiens_hsa05152	0.37722883
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.37391994
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.37370209
94	p53 signaling pathway_Homo sapiens_hsa04115	0.36230429
95	Insulin signaling pathway_Homo sapiens_hsa04910	0.36021483
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.34997314
97	Prolactin signaling pathway_Homo sapiens_hsa04917	0.34434420
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34187340
99	Toxoplasmosis_Homo sapiens_hsa05145	0.33372514
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.30880699

KRTAP11-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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