ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	9.90256320
2	virion attachment to host cell (GO:0019062)	9.90256320
3	citrulline biosynthetic process (GO:0019240)	8.90976077
4	adhesion of symbiont to host (GO:0044406)	8.32910877
5	hair follicle morphogenesis (GO:0031069)	8.20806488
6	peptide cross-linking (GO:0018149)	8.17885575
7	cell wall macromolecule catabolic process (GO:0016998)	7.06067000
8	cell wall macromolecule metabolic process (GO:0044036)	7.06067000
9	intermediate filament cytoskeleton organization (GO:0045104)	6.57459805
10	intermediate filament-based process (GO:0045103)	6.36462144
11	epidermis development (GO:0008544)	6.13788708
12	establishment of skin barrier (GO:0061436)	5.96003155
13	citrulline metabolic process (GO:0000052)	5.83278041
14	keratinocyte differentiation (GO:0030216)	5.75140216
15	molting cycle process (GO:0022404)	5.37548706
16	hair cycle process (GO:0022405)	5.37548706
17	regulation of water loss via skin (GO:0033561)	5.25693211
18	skin morphogenesis (GO:0043589)	5.05409997
19	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.95799279
20	peptidyl-arginine modification (GO:0018195)	4.91103344
21	epidermal cell differentiation (GO:0009913)	4.53086121
22	hemidesmosome assembly (GO:0031581)	4.44586055
23	tooth mineralization (GO:0034505)	4.19301563
24	hair cycle (GO:0042633)	34.1945505
25	molting cycle (GO:0042303)	34.1945505
26	keratinocyte development (GO:0003334)	3.90098267
27	multicellular organismal water homeostasis (GO:0050891)	3.54472511
28	negative regulation of keratinocyte proliferation (GO:0010839)	3.33392726
29	positive regulation of hair follicle development (GO:0051798)	3.31649794
30	positive regulation of hair cycle (GO:0042635)	3.31649794
31	regulation of keratinocyte differentiation (GO:0045616)	3.28639330
32	hair follicle development (GO:0001942)	3.27552966
33	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.20585332
34	bone trabecula formation (GO:0060346)	3.11348653
35	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.10367056
36	fatty acid elongation (GO:0030497)	3.08306078
37	regulation of hair follicle development (GO:0051797)	3.08268202
38	positive regulation of meiotic cell cycle (GO:0051446)	2.95344069
39	epithelium development (GO:0060429)	2.92687304
40	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.91499932
41	water homeostasis (GO:0030104)	2.89572967
42	regulation of hair cycle (GO:0042634)	2.76467714
43	gap junction assembly (GO:0016264)	2.71261584
44	atrioventricular valve morphogenesis (GO:0003181)	2.69102508
45	positive regulation of epidermis development (GO:0045684)	2.68638148
46	myotube differentiation (GO:0014902)	2.66397167
47	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.63923483
48	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.54161857
49	regulation of epidermal cell differentiation (GO:0045604)	2.53728035
50	negative regulation of protein localization to plasma membrane (GO:1903077)	2.52194582
51	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.48255060
52	lymph vessel development (GO:0001945)	2.45167633
53	ectoderm development (GO:0007398)	2.45095182
54	regulation of epidermis development (GO:0045682)	2.44090613
55	negative regulation of cell fate specification (GO:0009996)	2.35442080
56	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.31601287
57	cranial suture morphogenesis (GO:0060363)	2.26929157
58	phosphatidylserine metabolic process (GO:0006658)	2.26652984
59	ventricular cardiac muscle cell action potential (GO:0086005)	2.26385711
60	wound healing, spreading of epidermal cells (GO:0035313)	2.23389758
61	skin development (GO:0043588)	2.21112347
62	outflow tract septum morphogenesis (GO:0003148)	2.14586806
63	positive regulation of epidermal cell differentiation (GO:0045606)	2.14576778
64	positive regulation of monocyte chemotaxis (GO:0090026)	2.12800771
65	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.12553150
66	negative regulation of epidermis development (GO:0045683)	2.10738075
67	regulation of ruffle assembly (GO:1900027)	2.10525307
68	regulation of cardioblast differentiation (GO:0051890)	2.10508290
69	coronary vasculature morphogenesis (GO:0060977)	2.03026818
70	ephrin receptor signaling pathway (GO:0048013)	2.00062940
71	intermediate filament organization (GO:0045109)	11.6720120
72	keratinization (GO:0031424)	11.3663992
73	desmosome organization (GO:0002934)	10.0374250
74	regulation of keratinocyte proliferation (GO:0010837)	1.99571338
75	aging (GO:0007568)	1.99300818
76	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.99204011
77	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.98797449
78	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.98646087
79	epithelial cell-cell adhesion (GO:0090136)	1.95617499
80	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.92390628
81	non-canonical Wnt signaling pathway (GO:0035567)	1.90760297
82	regulation of heart rate by cardiac conduction (GO:0086091)	1.90320928
83	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.87480521
84	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.85218968
85	regulation of cardioblast proliferation (GO:0003264)	1.85218968
86	cell communication involved in cardiac conduction (GO:0086065)	1.78415882
87	very long-chain fatty acid metabolic process (GO:0000038)	1.78372080
88	cardiac right ventricle morphogenesis (GO:0003215)	1.76697989
89	outer ear morphogenesis (GO:0042473)	1.72571417
90	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.71934660
91	negative regulation of epidermal cell differentiation (GO:0045605)	1.71143101
92	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.71064745
93	negative regulation of cell fate commitment (GO:0010454)	1.67742086
94	alditol phosphate metabolic process (GO:0052646)	1.65931908
95	keratinocyte proliferation (GO:0043616)	1.65522362
96	primary alcohol catabolic process (GO:0034310)	1.65037942
97	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	1.64577061
98	cell-substrate junction assembly (GO:0007044)	1.63651657
99	eyelid development in camera-type eye (GO:0061029)	1.62541592
100	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.61563876

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	8.45719772
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.07627424
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.48121955
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.71124023
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.31318790
6	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.15783647
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.1417166
8	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.99067369
9	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.82533850
10	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.78247300
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.76336622
12	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.74939627
13	E2F1_20622854_ChIP-Seq_HELA_Human	1.71619783
14	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.67900309
15	CTCF_27219007_Chip-Seq_Bcells_Human	1.66445930
16	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.63563728
17	ERG_20517297_ChIP-Seq_VCAP_Human	1.62122426
18	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.56881867
19	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.54397372
20	P53_21459846_ChIP-Seq_SAOS-2_Human	1.54020620
21	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.49621402
22	TP63_22573176_ChIP-Seq_HFKS_Human	1.47278918
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.46522985
24	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.44985658
25	LXR_22292898_ChIP-Seq_THP-1_Human	1.42803028
26	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.42700173
27	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.41480587
28	BCL6_27268052_Chip-Seq_Bcells_Human	1.38814713
29	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.38423320
30	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.38423320
31	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.37297703
32	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.35058823
33	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30062684
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.29231376
35	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28364551
36	BCOR_27268052_Chip-Seq_Bcells_Human	1.28064570
37	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.27687423
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25525986
39	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23103579
40	ATF3_27146783_Chip-Seq_COLON_Human	1.23040029
41	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.22540970
42	AHR_22903824_ChIP-Seq_MCF-7_Human	1.22197981
43	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19744727
44	PHF8_20622854_ChIP-Seq_HELA_Human	1.19182446
45	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17657078
46	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.15667097
47	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.15653277
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15613653
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.15581963
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14252054
51	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12044593
52	P68_20966046_ChIP-Seq_HELA_Human	1.11923832
53	TP63_23658742_ChIP-Seq_EP156T_Human	1.11278190
54	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.08775692
55	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06430150
56	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.05984550
57	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04430210
58	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.03933374
59	SOX2_21211035_ChIP-Seq_LN229_Human	1.03458830
60	SMC4_20622854_ChIP-Seq_HELA_Human	1.03247549
61	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.02972749
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01852894
63	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.01460530
64	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.01319499
65	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.00921793
66	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00243087
67	TP53_18474530_ChIP-ChIP_U2OS_Human	0.99587364
68	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98950078
69	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.97595067
70	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94924400
71	AR_21572438_ChIP-Seq_LNCaP_Human	0.94832044
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94551742
73	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92939604
74	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.92359720
75	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91970464
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91781200
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91430525
78	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.90972082
79	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.89547480
80	RXR_22108803_ChIP-Seq_LS180_Human	0.89372643
81	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.89265701
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89062153
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.88674815
84	* RAC3_21632823_ChIP-Seq_H3396_Human	0.88610122
85	SPI1_20517297_ChIP-Seq_HL60_Human	0.87493632
86	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.86668616
87	ZNF263_19887448_ChIP-Seq_K562_Human	0.86474363
88	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.84941285
89	SOX2_20726797_ChIP-Seq_SW620_Human	0.82961060
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.82749746
91	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.82677081
92	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.82612472
93	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.81897356
94	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.81602868
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.78260451
96	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.78178769
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.78178769
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.76072672
99	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.75871076
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.73327804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002098_abnormal_vibrissa_morphology	7.29747046
2	MP0000579_abnormal_nail_morphology	7.27083981
3	MP0000647_abnormal_sebaceous_gland	6.64099087
4	MP0002796_impaired_skin_barrier	6.07788105
5	MP0005275_abnormal_skin_tensile	5.21930835
6	MP0010234_abnormal_vibrissa_follicle	5.13499014
7	MP0000383_abnormal_hair_follicle	4.44478920
8	MP0000377_abnormal_hair_follicle	4.07921881
9	MP0010678_abnormal_skin_adnexa	3.95763946
10	MP0005501_abnormal_skin_physiology	3.76694530
11	MP0000427_abnormal_hair_cycle	3.65212243
12	MP0003705_abnormal_hypodermis_morpholog	3.57384620
13	MP0002254_reproductive_system_inflammat	3.09723690
14	MP0001216_abnormal_epidermal_layer	2.64320985
15	MP0004381_abnormal_hair_follicle	2.42440217
16	MP0000367_abnormal_coat/_hair	2.36588447
17	MP0010771_integument_phenotype	2.32107110
18	MP0004947_skin_inflammation	2.24118161
19	MP0001243_abnormal_dermal_layer	2.21551310
20	MP0002060_abnormal_skin_morphology	2.20121627
21	MP0003453_abnormal_keratinocyte_physiol	2.07473701
22	MP0002234_abnormal_pharynx_morphology	2.04089221
23	MP0000467_abnormal_esophagus_morphology	1.52618884
24	MP0009931_abnormal_skin_appearance	1.49322759
25	MP0009053_abnormal_anal_canal	1.45000064
26	MP0000762_abnormal_tongue_morphology	1.39425076
27	MP0003566_abnormal_cell_adhesion	1.31554786
28	MP0003941_abnormal_skin_development	1.20004106
29	MP0001661_extended_life_span	1.14861118
30	MP0005409_darkened_coat_color	1.07446470
31	MP0004885_abnormal_endolymph	0.99599858
32	MP0001191_abnormal_skin_condition	0.99406831
33	MP0004185_abnormal_adipocyte_glucose	0.91156834
34	MP0002095_abnormal_skin_pigmentation	0.91077410
35	MP0004264_abnormal_extraembryonic_tissu	0.85292794
36	MP0001851_eye_inflammation	0.75950378
37	MP0001346_abnormal_lacrimal_gland	0.72907705
38	MP0008438_abnormal_cutaneous_collagen	0.71807717
39	MP0001340_abnormal_eyelid_morphology	0.70938324
40	MP0000566_synostosis	0.67100849
41	MP0003315_abnormal_perineum_morphology	0.65278548
42	MP0010030_abnormal_orbit_morphology	0.64626793
43	MP0001849_ear_inflammation	0.62517756
44	MP0000627_abnormal_mammary_gland	0.55652418
45	MP0002877_abnormal_melanocyte_morpholog	0.54913458
46	MP0002249_abnormal_larynx_morphology	0.54693651
47	MP0003755_abnormal_palate_morphology	0.50576901
48	MP0002282_abnormal_trachea_morphology	0.49845447
49	MP0005451_abnormal_body_composition	0.49540599
50	MP0001784_abnormal_fluid_regulation	0.48178984
51	MP0000678_abnormal_parathyroid_gland	0.44525430
52	MP0003191_abnormal_cellular_cholesterol	0.44304588
53	MP0002970_abnormal_white_adipose	0.44278044
54	MP0003385_abnormal_body_wall	0.42114670
55	MP0002111_abnormal_tail_morphology	0.41339083
56	MP0005075_abnormal_melanosome_morpholog	0.39532396
57	MP0005023_abnormal_wound_healing	0.39478468
58	MP0002177_abnormal_outer_ear	0.36337532
59	MP0004272_abnormal_basement_membrane	0.35993334
60	MP0000465_gastrointestinal_hemorrhage	0.29781446
61	MP0000537_abnormal_urethra_morphology	0.29100162
62	MP0009840_abnormal_foam_cell	0.25897416
63	MP0009379_abnormal_foot_pigmentation	0.25815220
64	MP0010352_gastrointestinal_tract_polyps	0.25229300
65	MP0004742_abnormal_vestibular_system	0.25058016
66	MP0000751_myopathy	0.23822011
67	MP0005248_abnormal_Harderian_gland	0.23706640
68	MP0003329_amyloid_beta_deposits	0.23655054
69	MP0002697_abnormal_eye_size	0.22194276
70	MP0003763_abnormal_thymus_physiology	0.21913052
71	MP0003300_gastrointestinal_ulcer	0.21656222
72	MP0000432_abnormal_head_morphology	0.21445983
73	MP0006054_spinal_hemorrhage	0.20779112
74	MP0001879_abnormal_lymphatic_vessel	0.20302225
75	MP0003935_abnormal_craniofacial_develop	0.19640934
76	MP0003950_abnormal_plasma_membrane	0.17724660
77	MP0000516_abnormal_urinary_system	0.16369334
78	MP0005367_renal/urinary_system_phenotyp	0.16369334
79	MP0000733_abnormal_muscle_development	0.16250947
80	MP0004019_abnormal_vitamin_homeostasis	0.15309156
81	MP0009384_cardiac_valve_regurgitation	0.14424909
82	MP0005666_abnormal_adipose_tissue	0.13970168
83	MP0003638_abnormal_response/metabolism_	0.13448588
84	MP0005375_adipose_tissue_phenotype	0.13296680
85	MP0000462_abnormal_digestive_system	0.12276054
86	MP0003448_altered_tumor_morphology	0.11918835
87	MP0002233_abnormal_nose_morphology	0.11725198
88	MP0003011_delayed_dark_adaptation	0.11048026
89	MP0005623_abnormal_meninges_morphology	0.10871525
90	MP0000747_muscle_weakness	0.09993353
91	MP0000604_amyloidosis	0.09711102
92	MP0008569_lethality_at_weaning	0.08731119
93	MP0005452_abnormal_adipose_tissue	0.08620818
94	MP0000428_abnormal_craniofacial_morphol	0.08461082
95	MP0006138_congestive_heart_failure	0.08137698
96	MP0004858_abnormal_nervous_system	0.08093911
97	MP0003045_fibrosis	0.07400178
98	MP0005508_abnormal_skeleton_morphology	0.07009343
99	MP0000013_abnormal_adipose_tissue	0.06214266
100	MP0005193_abnormal_anterior_eye	0.05925705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.88043132
2	Nail dystrophy (HP:0008404)	7.19382358
3	Abnormal hair laboratory examination (HP:0003328)	5.56536984
4	Fragile nails (HP:0001808)	5.47977131
5	Abnormality of nail color (HP:0100643)	5.38780725
6	Fine hair (HP:0002213)	5.29305504
7	Onycholysis (HP:0001806)	4.80392884
8	Increased IgE level (HP:0003212)	4.80248306
9	Palmoplantar hyperkeratosis (HP:0000972)	4.54879122
10	Alopecia of scalp (HP:0002293)	4.48087545
11	Palmar hyperkeratosis (HP:0010765)	4.28108989
12	Plantar hyperkeratosis (HP:0007556)	4.14331902
13	Right ventricular cardiomyopathy (HP:0011663)	4.13425979
14	Thick nail (HP:0001805)	3.79545312
15	Follicular hyperkeratosis (HP:0007502)	3.77581415
16	Erythema (HP:0010783)	3.65641325
17	Sparse eyelashes (HP:0000653)	3.45352244
18	Abnormality of the frontal sinuses (HP:0002687)	3.32532610
19	Amelogenesis imperfecta (HP:0000705)	3.24075535
20	Erythroderma (HP:0001019)	3.05203578
21	Parakeratosis (HP:0001036)	2.91930791
22	Milia (HP:0001056)	2.89922123
23	Dry hair (HP:0011359)	2.85786798
24	Oral leukoplakia (HP:0002745)	2.84788711
25	Curly hair (HP:0002212)	2.67565835
26	Aplasia cutis congenita (HP:0001057)	2.67060443
27	Neck muscle weakness (HP:0000467)	2.58153569
28	Intention tremor (HP:0002080)	2.55909529
29	Congenital, generalized hypertrichosis (HP:0004540)	2.54185470
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.51169211
31	Ridged nail (HP:0001807)	2.47578524
32	Advanced eruption of teeth (HP:0006288)	2.24872111
33	Natal tooth (HP:0000695)	2.24380202
34	Abnormal blistering of the skin (HP:0008066)	2.19558125
35	Torticollis (HP:0000473)	2.19350002
36	Corneal erosion (HP:0200020)	2.06656715
37	Hypohidrosis (HP:0000966)	2.02673996
38	Ventricular tachycardia (HP:0004756)	2.01139341
39	Hypotrichosis (HP:0001006)	15.2552543
40	Woolly hair (HP:0002224)	11.2697207
41	Abnormality of hair growth rate (HP:0011363)	11.2375710
42	Slow-growing hair (HP:0002217)	11.2375710
43	Brittle hair (HP:0002299)	10.2271518
44	Abnormality of the pupil (HP:0000615)	1.95063485
45	Concave nail (HP:0001598)	1.92859516
46	Palmoplantar keratoderma (HP:0000982)	1.91727332
47	Difficulty walking (HP:0002355)	1.88430152
48	Pruritus (HP:0000989)	1.88422453
49	Abnormality of the dental root (HP:0006486)	1.88420590
50	Taurodontia (HP:0000679)	1.88420590
51	Abnormality of permanent molar morphology (HP:0011071)	1.88420590
52	Abnormality of dental color (HP:0011073)	1.88399200
53	Abnormality of the parietal bone (HP:0002696)	1.88223916
54	Abnormality of molar (HP:0011077)	1.86258803
55	Abnormality of molar morphology (HP:0011070)	1.86258803
56	Widely patent fontanelles and sutures (HP:0004492)	1.84326738
57	Craniofacial dystonia (HP:0012179)	1.83120602
58	Conjunctival hamartoma (HP:0100780)	1.82229705
59	Hyporeflexia of lower limbs (HP:0002600)	1.76443108
60	Round ear (HP:0100830)	1.70700767
61	Focal dystonia (HP:0004373)	1.67079472
62	Ventricular fibrillation (HP:0001663)	1.66582133
63	Unilateral renal agenesis (HP:0000122)	1.66557063
64	Abnormality of the dental pulp (HP:0006479)	1.64610544
65	Absent eyelashes (HP:0000561)	1.62631433
66	Recurrent corneal erosions (HP:0000495)	1.62470720
67	Abnormality of the aortic arch (HP:0012303)	1.62272449
68	Type 1 muscle fiber predominance (HP:0003803)	1.55847449
69	Sudden death (HP:0001699)	1.54684300
70	Distal lower limb muscle weakness (HP:0009053)	1.54205699
71	Acanthosis nigricans (HP:0000956)	1.50069973
72	Abnormality of placental membranes (HP:0011409)	1.49042000
73	Amniotic constriction ring (HP:0009775)	1.49042000
74	Blepharitis (HP:0000498)	1.46446175
75	Lip pit (HP:0100267)	1.41765289
76	Craniofacial hyperostosis (HP:0004493)	1.41493117
77	Fatigable weakness (HP:0003473)	1.39973825
78	Abnormality of the neuromuscular junction (HP:0003398)	1.39973825
79	Heterogeneous (HP:0001425)	1.39843206
80	Distal arthrogryposis (HP:0005684)	1.38783573
81	Hypergammaglobulinemia (HP:0010702)	1.37113601
82	Gangrene (HP:0100758)	1.35943200
83	Keratoconjunctivitis sicca (HP:0001097)	1.35478070
84	Autoamputation (HP:0001218)	1.32371336
85	Achilles tendon contracture (HP:0001771)	1.31052439
86	Carious teeth (HP:0000670)	1.28973303
87	Widely spaced teeth (HP:0000687)	1.28368263
88	Increased connective tissue (HP:0009025)	1.27836232
89	Ectropion (HP:0000656)	1.26181880
90	Calcaneovalgus deformity (HP:0001848)	1.23262570
91	Abnormality of the Achilles tendon (HP:0005109)	1.22794421
92	Variable expressivity (HP:0003828)	1.21495178
93	Sparse scalp hair (HP:0002209)	1.21003695
94	Keratoconjunctivitis (HP:0001096)	1.18889937
95	Hamartoma of the eye (HP:0010568)	1.18717322
96	Nemaline bodies (HP:0003798)	1.17935681
97	Abnormality of the fingernails (HP:0001231)	1.17024718
98	Ulnar deviation of the wrist (HP:0003049)	1.16086033
99	Bronchomalacia (HP:0002780)	1.14690925
100	Atrophic scars (HP:0001075)	1.14248313

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.67938079
2	FER	4.08846533
3	MAPKAPK3	3.98927547
4	EPHB2	3.42865339
5	MAP3K6	3.42645868
6	ERN1	3.41864821
7	PIK3CG	3.13825606
8	TAOK1	2.99219567
9	MAP3K3	2.71787100
10	LATS1	2.53794903
11	MAP3K2	2.35124011
12	TRIB3	2.33383980
13	TTN	2.28207504
14	RPS6KB2	1.94855606
15	MAP3K11	1.87162518
16	EPHB1	1.83387740
17	BCR	1.62560259
18	LATS2	1.61988098
19	MAP2K6	1.58910575
20	EEF2K	1.53897834
21	OBSCN	1.52806823
22	FGFR2	1.49004625
23	NME1	1.37328316
24	RIPK1	1.27399433
25	FGFR1	1.18542154
26	MAP3K1	1.18496856
27	MAP2K3	1.15418775
28	KSR2	1.14435827
29	BMX	1.13600947
30	PBK	1.11819882
31	MST1R	1.07069060
32	CDK6	1.06549957
33	MAPKAPK2	1.06409851
34	FGFR4	1.05139624
35	BLK	1.04311376
36	LRRK2	0.99284228
37	MAP3K7	0.98756573
38	FGFR3	0.94248567
39	PKN2	0.89007376
40	PDGFRA	0.86282712
41	CDK19	0.81802620
42	PRKD1	0.80985598
43	PTK6	0.79205239
44	MAP2K4	0.74518583
45	MAP3K9	0.74138609
46	DYRK1B	0.72107571
47	MAP2K1	0.71424310
48	PAK3	0.71336771
49	PTK2	0.71277828
50	STK38	0.71144703
51	STK38L	0.71021681
52	PRKCI	0.70289612
53	PIM2	0.67125331
54	PAK6	0.65387310
55	TESK1	0.64057561
56	ERBB4	0.62334440
57	SIK1	0.61038794
58	PRKCH	0.59918313
59	PHKG2	0.59516208
60	PHKG1	0.59516208
61	MET	0.58611621
62	MST4	0.58362314
63	NTRK2	0.57947830
64	PAK4	0.55813467
65	ERBB2	0.55645312
66	TYRO3	0.55131288
67	DDR2	0.55015583
68	TRPM7	0.51860006
69	RPS6KA4	0.48643863
70	GSK3A	0.46056250
71	TGFBR1	0.45212810
72	RET	0.44962593
73	MAPK12	0.43006631
74	PAK2	0.42139221
75	LIMK1	0.41827487
76	CSNK1E	0.40819492
77	PRKD3	0.37647735
78	MAP3K5	0.37358064
79	RPS6KA1	0.35894920
80	EPHA3	0.35667830
81	MAP2K2	0.35034027
82	CSNK1G1	0.31451997
83	CSNK1A1	0.30944053
84	ICK	0.29830849
85	FYN	0.29706976
86	CSNK1A1L	0.29208373
87	ROCK2	0.29181796
88	NEK1	0.28628883
89	CSNK1G3	0.28281961
90	BCKDK	0.27926830
91	MAP3K10	0.27920226
92	FES	0.27766892
93	PRKACA	0.27454609
94	CSNK1D	0.25401705
95	JAK2	0.24749207
96	PIK3CA	0.23524625
97	JAK1	0.23457235
98	MAP3K8	0.23079866
99	STK11	0.22845738
100	ERBB3	0.22704126

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.53181727
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.52722624
3	Fatty acid elongation_Homo sapiens_hsa00062	3.22801461
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.90697678
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.57136624
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.35447892
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.93566900
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.75989644
9	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.74391405
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.67718940
11	Axon guidance_Homo sapiens_hsa04360	1.67343340
12	Melanogenesis_Homo sapiens_hsa04916	1.64073830
13	VEGF signaling pathway_Homo sapiens_hsa04370	1.62266866
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.46370007
15	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.35716933
16	Histidine metabolism_Homo sapiens_hsa00340	1.32035234
17	Glioma_Homo sapiens_hsa05214	1.31882494
18	Tight junction_Homo sapiens_hsa04530	1.27354437
19	Proteoglycans in cancer_Homo sapiens_hsa05205	1.24664707
20	Hippo signaling pathway_Homo sapiens_hsa04390	1.24543955
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.22542065
22	Bladder cancer_Homo sapiens_hsa05219	1.21813640
23	Thyroid cancer_Homo sapiens_hsa05216	1.21632674
24	GnRH signaling pathway_Homo sapiens_hsa04912	1.21344055
25	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.16157686
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.15979571
27	Mineral absorption_Homo sapiens_hsa04978	1.15136892
28	Pancreatic secretion_Homo sapiens_hsa04972	1.13419425
29	Acute myeloid leukemia_Homo sapiens_hsa05221	1.12337315
30	Long-term potentiation_Homo sapiens_hsa04720	1.08886822
31	Caffeine metabolism_Homo sapiens_hsa00232	1.05666717
32	ECM-receptor interaction_Homo sapiens_hsa04512	1.05568914
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.02613552
34	PPAR signaling pathway_Homo sapiens_hsa03320	0.97517347
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.95699261
36	Adherens junction_Homo sapiens_hsa04520	0.93175862
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.93046826
38	Long-term depression_Homo sapiens_hsa04730	0.91827739
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89041018
40	Wnt signaling pathway_Homo sapiens_hsa04310	0.87181719
41	Tyrosine metabolism_Homo sapiens_hsa00350	0.85846602
42	Pertussis_Homo sapiens_hsa05133	0.85123403
43	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.85052652
44	Ras signaling pathway_Homo sapiens_hsa04014	0.84640137
45	Gastric acid secretion_Homo sapiens_hsa04971	0.83500465
46	Phototransduction_Homo sapiens_hsa04744	0.82540449
47	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81803045
48	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.81327171
49	Renin secretion_Homo sapiens_hsa04924	0.78263724
50	Endometrial cancer_Homo sapiens_hsa05213	0.77223772
51	Amoebiasis_Homo sapiens_hsa05146	0.76149525
52	Non-small cell lung cancer_Homo sapiens_hsa05223	0.74091517
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73905377
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.73718993
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72820026
56	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.69181121
57	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67222118
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.64979775
59	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64420679
60	Salivary secretion_Homo sapiens_hsa04970	0.64089711
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.64081170
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60510388
63	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59672365
64	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57881126
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.57385833
66	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.56622021
67	Insulin resistance_Homo sapiens_hsa04931	0.56018463
68	Focal adhesion_Homo sapiens_hsa04510	0.54236514
69	Gap junction_Homo sapiens_hsa04540	0.51871913
70	Renal cell carcinoma_Homo sapiens_hsa05211	0.51851143
71	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.51521726
72	Hepatitis C_Homo sapiens_hsa05160	0.50794152
73	Protein digestion and absorption_Homo sapiens_hsa04974	0.50696912
74	Platelet activation_Homo sapiens_hsa04611	0.50445984
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48632462
76	Salmonella infection_Homo sapiens_hsa05132	0.48604280
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48070289
78	Notch signaling pathway_Homo sapiens_hsa04330	0.47982376
79	Butanoate metabolism_Homo sapiens_hsa00650	0.47650213
80	Prion diseases_Homo sapiens_hsa05020	0.47140468
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46588857
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45864431
83	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.45060112
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.44993565
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43286271
86	ErbB signaling pathway_Homo sapiens_hsa04012	0.43222618
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43136152
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.42878373
89	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.42363552
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42084789
91	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41854097
92	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.39897416
93	Olfactory transduction_Homo sapiens_hsa04740	0.38448329
94	Fatty acid degradation_Homo sapiens_hsa00071	0.38016646
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.37577854
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.37421295
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.37076656
98	Tuberculosis_Homo sapiens_hsa05152	0.36864975
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.36060595
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.34940529

KRTAP12-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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