KRTAP13-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hair keratins and hair keratin-associated proteins (KAPs), such as KRTAP13-1, are the main structural proteins of hair fibers (Rogers et al., 2002 [PubMed 12359730]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)8.79121412
2citrulline biosynthetic process (GO:0019240)8.54320682
3adhesion of symbiont to host (GO:0044406)8.48368421
4hair follicle morphogenesis (GO:0031069)8.17726461
5establishment of skin barrier (GO:0061436)6.95363157
6intermediate filament cytoskeleton organization (GO:0045104)6.67475429
7intermediate filament-based process (GO:0045103)6.51472986
8cell wall macromolecule catabolic process (GO:0016998)6.43022089
9cell wall macromolecule metabolic process (GO:0044036)6.43022089
10epidermis development (GO:0008544)6.26193942
11regulation of water loss via skin (GO:0033561)6.13889539
12keratinocyte differentiation (GO:0030216)6.10406725
13citrulline metabolic process (GO:0000052)5.60440417
14hair cycle process (GO:0022405)5.33905167
15molting cycle process (GO:0022404)5.33905167
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.09103080
17skin morphogenesis (GO:0043589)4.98062814
18hemidesmosome assembly (GO:0031581)4.79541759
19epidermal cell differentiation (GO:0009913)4.74308933
20peptidyl-arginine modification (GO:0018195)4.64414415
21multicellular organismal water homeostasis (GO:0050891)4.15900669
22hair cycle (GO:0042633)33.9208698
23molting cycle (GO:0042303)33.9208698
24keratinocyte development (GO:0003334)3.89217384
25tooth mineralization (GO:0034505)3.86134872
26regulation of keratinocyte differentiation (GO:0045616)3.42290589
27phosphatidylinositol acyl-chain remodeling (GO:0036149)3.42084842
28water homeostasis (GO:0030104)3.39853048
29negative regulation of keratinocyte proliferation (GO:0010839)3.37987343
30hair follicle development (GO:0001942)3.24199507
31negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.20740969
32phosphatidylserine acyl-chain remodeling (GO:0036150)3.17593429
33positive regulation of hair follicle development (GO:0051798)3.15537929
34positive regulation of hair cycle (GO:0042635)3.15537929
35bone trabecula formation (GO:0060346)3.00673504
36fatty acid elongation (GO:0030497)2.98546920
37epithelium development (GO:0060429)2.96130501
38regulation of hair follicle development (GO:0051797)2.95810163
39phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.82489916
40positive regulation of meiotic cell cycle (GO:0051446)2.82480661
41ectoderm development (GO:0007398)2.75918767
42regulation of hair cycle (GO:0042634)2.73008056
43gap junction assembly (GO:0016264)2.70673455
44positive regulation of epidermis development (GO:0045684)2.66647542
45regulation of epidermal cell differentiation (GO:0045604)2.66053539
46negative regulation of protein localization to plasma membrane (GO:1903077)2.61868325
47atrioventricular valve morphogenesis (GO:0003181)2.56729986
48regulation of epidermis development (GO:0045682)2.52036689
49phosphatidylserine metabolic process (GO:0006658)2.41279171
50epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.35216351
51phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.34635510
52ventricular cardiac muscle cell action potential (GO:0086005)2.34109595
53negative regulation of cell fate specification (GO:0009996)2.29293156
54positive regulation of monocyte chemotaxis (GO:0090026)2.27159183
55lymph vessel development (GO:0001945)2.25104281
56cell surface receptor signaling pathway involved in heart development (GO:0061311)2.21571645
57skin development (GO:0043588)2.21270962
58regulation of mesenchymal cell apoptotic process (GO:2001053)2.20834197
59positive regulation of epidermal cell differentiation (GO:0045606)2.19760306
60wound healing, spreading of epidermal cells (GO:0035313)2.18295855
61cranial suture morphogenesis (GO:0060363)2.17584712
62regulation of cardioblast differentiation (GO:0051890)2.09074520
63phosphatidylcholine acyl-chain remodeling (GO:0036151)2.07101294
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.03210806
65myotube differentiation (GO:0014902)2.03175787
66regulation of ruffle assembly (GO:1900027)2.00947592
67epithelial cell-cell adhesion (GO:0090136)2.00088224
68keratinization (GO:0031424)13.0369322
69intermediate filament organization (GO:0045109)11.9918001
70desmosome organization (GO:0002934)10.2011543
71adhesion of symbiont to host cell (GO:0044650)10.0721318
72virion attachment to host cell (GO:0019062)10.0721318
73outflow tract septum morphogenesis (GO:0003148)1.98250029
74aging (GO:0007568)1.98196106
75regulation of heart rate by cardiac conduction (GO:0086091)1.97758350
76long-chain fatty acid biosynthetic process (GO:0042759)1.94286000
77negative regulation of epidermis development (GO:0045683)1.93454391
78regulation of keratinocyte proliferation (GO:0010837)1.92336312
79planar cell polarity pathway involved in neural tube closure (GO:0090179)1.87773211
80ephrin receptor signaling pathway (GO:0048013)1.84441822
81regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.83196035
82cell communication involved in cardiac conduction (GO:0086065)1.83066299
83non-canonical Wnt signaling pathway (GO:0035567)1.81145842
84very long-chain fatty acid metabolic process (GO:0000038)1.80882698
85alditol phosphate metabolic process (GO:0052646)1.77737059
86coronary vasculature morphogenesis (GO:0060977)1.77586123
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.73123495
88regulation of secondary heart field cardioblast proliferation (GO:0003266)1.71197318
89regulation of cardioblast proliferation (GO:0003264)1.71197318
90keratinocyte proliferation (GO:0043616)1.70274777
91cell-substrate junction assembly (GO:0007044)1.69845499
92long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.67957650
93primary alcohol catabolic process (GO:0034310)1.67463990
94regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.66629242
95negative regulation of cell fate commitment (GO:0010454)1.66416760
96long-chain fatty-acyl-CoA metabolic process (GO:0035336)1.63073716
97regulation of monocyte chemotaxis (GO:0090025)1.62920168
98craniofacial suture morphogenesis (GO:0097094)1.59585030
99establishment of tissue polarity (GO:0007164)1.59427604
100establishment of planar polarity (GO:0001736)1.59427604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.06239533
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.88372514
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.65115684
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.80327357
5CTCF_20526341_ChIP-Seq_ESCs_Human2.38200138
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.08235103
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.03496926
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.4634789
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92120432
10TAF2_19829295_ChIP-Seq_ESCs_Human1.84299885
11E2F1_20622854_ChIP-Seq_HELA_Human1.84080245
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77422099
13P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.76421943
14EGR1_19032775_ChIP-ChIP_M12_Human1.74977088
15CSB_26484114_Chip-Seq_FIBROBLAST_Human1.73000798
16NANOG_20526341_ChIP-Seq_ESCs_Human1.72862803
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70700882
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66060949
19CTCF_27219007_Chip-Seq_Bcells_Human1.64360253
20P53_21459846_ChIP-Seq_SAOS-2_Human1.60944975
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.55572196
22TP63_22573176_ChIP-Seq_HFKS_Human1.51445119
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.51064438
24BCL6_27268052_Chip-Seq_Bcells_Human1.49512833
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47335419
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47335419
27RACK7_27058665_Chip-Seq_MCF-7_Human1.46815713
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44961441
29BCOR_27268052_Chip-Seq_Bcells_Human1.43672778
30* ERG_20517297_ChIP-Seq_VCAP_Human1.41600174
31LXR_22292898_ChIP-Seq_THP-1_Human1.40125442
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.40121053
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33508028
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32482198
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.32258513
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31650175
37* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.31231600
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30407181
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30387259
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.28791512
41ATF3_27146783_Chip-Seq_COLON_Human1.28714545
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28393041
43AHR_22903824_ChIP-Seq_MCF-7_Human1.26286661
44CEBPB_22108803_ChIP-Seq_LS180_Human1.22784178
45P68_20966046_ChIP-Seq_HELA_Human1.21967040
46PHF8_20622854_ChIP-Seq_HELA_Human1.21753495
47* YY1_22570637_ChIP-Seq_MALME-3M_Human1.19361634
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.17348732
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16199594
50TP63_23658742_ChIP-Seq_EP156T_Human1.15655598
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.15299659
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14591349
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.13762206
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11779500
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10278893
56RAC3_21632823_ChIP-Seq_H3396_Human1.09974905
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07802097
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07675752
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07324983
60JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07189144
61SMC4_20622854_ChIP-Seq_HELA_Human1.06759457
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06569489
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04275019
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.03378617
65SOX2_21211035_ChIP-Seq_LN229_Human1.02730773
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.02364240
67GATA4_25053715_ChIP-Seq_YYC3_Human1.01942744
68GATA6_21074721_ChIP-Seq_CACO-2_Human1.01813407
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01264201
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00797158
71TP53_18474530_ChIP-ChIP_U2OS_Human1.00506124
72KLF5_25053715_ChIP-Seq_YYC3_Human0.99560802
73FOXH1_21741376_ChIP-Seq_ESCs_Human0.97324853
74SPI1_20517297_ChIP-Seq_HL60_Human0.96765926
75* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96167876
76RXR_22108803_ChIP-Seq_LS180_Human0.93883747
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93208428
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93045472
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91775675
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91111521
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91047978
82RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91024916
83RING1B_27294783_Chip-Seq_ESCs_Mouse0.89781167
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89773852
85RUNX1_27514584_Chip-Seq_MCF-7_Human0.89496257
86EZH2_27294783_Chip-Seq_ESCs_Mouse0.89416235
87ERG_21242973_ChIP-ChIP_JURKAT_Human0.88062048
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.87491398
89SOX2_20726797_ChIP-Seq_SW620_Human0.84945979
90AR_21572438_ChIP-Seq_LNCaP_Human0.83878156
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82082434
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79871938
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79024295
94ZNF263_19887448_ChIP-Seq_K562_Human0.78586869
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77879119
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.77095076
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76242548
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.75997067
99EZH2_27304074_Chip-Seq_ESCs_Mouse0.75350987
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75337411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.47431842
2MP0002098_abnormal_vibrissa_morphology7.01249240
3MP0000647_abnormal_sebaceous_gland6.33451738
4MP0002796_impaired_skin_barrier6.21128266
5MP0005275_abnormal_skin_tensile5.36672270
6MP0010234_abnormal_vibrissa_follicle4.92796973
7MP0000383_abnormal_hair_follicle4.57938488
8MP0010678_abnormal_skin_adnexa4.02762107
9MP0000377_abnormal_hair_follicle4.01964675
10MP0005501_abnormal_skin_physiology3.84989485
11MP0003705_abnormal_hypodermis_morpholog3.58952395
12MP0000427_abnormal_hair_cycle3.54447920
13MP0002254_reproductive_system_inflammat3.17134465
14MP0001216_abnormal_epidermal_layer2.71191834
15MP0004381_abnormal_hair_follicle2.51103343
16MP0010771_integument_phenotype2.39487932
17MP0004947_skin_inflammation2.39231274
18MP0000367_abnormal_coat/_hair2.33463345
19MP0002060_abnormal_skin_morphology2.22669692
20MP0001243_abnormal_dermal_layer2.15871616
21MP0003453_abnormal_keratinocyte_physiol2.15235186
22MP0002234_abnormal_pharynx_morphology2.03141288
23MP0000467_abnormal_esophagus_morphology1.74633694
24MP0009931_abnormal_skin_appearance1.52181364
25MP0000762_abnormal_tongue_morphology1.50607975
26MP0009053_abnormal_anal_canal1.46108958
27MP0003941_abnormal_skin_development1.42051670
28MP0003566_abnormal_cell_adhesion1.37882594
29MP0005409_darkened_coat_color1.24545900
30MP0001191_abnormal_skin_condition1.01832262
31MP0004185_abnormal_adipocyte_glucose0.94881581
32MP0004885_abnormal_endolymph0.93233367
33MP0002095_abnormal_skin_pigmentation0.91147674
34MP0004264_abnormal_extraembryonic_tissu0.82820748
35MP0001851_eye_inflammation0.79094028
36MP0005451_abnormal_body_composition0.78991438
37MP0001346_abnormal_lacrimal_gland0.75737201
38MP0008438_abnormal_cutaneous_collagen0.72646442
39MP0001340_abnormal_eyelid_morphology0.67719061
40MP0001661_extended_life_span0.66910097
41MP0010030_abnormal_orbit_morphology0.65798838
42MP0003315_abnormal_perineum_morphology0.63533761
43MP0000566_synostosis0.62251268
44MP0002877_abnormal_melanocyte_morpholog0.56839168
45MP0001849_ear_inflammation0.56522715
46MP0000627_abnormal_mammary_gland0.53888214
47MP0003191_abnormal_cellular_cholesterol0.52705684
48MP0003755_abnormal_palate_morphology0.48750479
49MP0001784_abnormal_fluid_regulation0.48619292
50MP0002282_abnormal_trachea_morphology0.47685163
51MP0005023_abnormal_wound_healing0.42405957
52MP0002970_abnormal_white_adipose0.41814998
53MP0004272_abnormal_basement_membrane0.39482347
54MP0002111_abnormal_tail_morphology0.38572404
55MP0002249_abnormal_larynx_morphology0.38192749
56MP0000537_abnormal_urethra_morphology0.36505070
57MP0000678_abnormal_parathyroid_gland0.35854077
58MP0002177_abnormal_outer_ear0.34998024
59MP0005075_abnormal_melanosome_morpholog0.33324240
60MP0003385_abnormal_body_wall0.32217335
61MP0010352_gastrointestinal_tract_polyps0.28766760
62MP0003950_abnormal_plasma_membrane0.27921069
63MP0000465_gastrointestinal_hemorrhage0.26254841
64MP0002697_abnormal_eye_size0.25747500
65MP0003329_amyloid_beta_deposits0.25215908
66MP0009840_abnormal_foam_cell0.24887691
67MP0001188_hyperpigmentation0.23388979
68MP0003763_abnormal_thymus_physiology0.20108517
69MP0005248_abnormal_Harderian_gland0.19813860
70MP0009379_abnormal_foot_pigmentation0.19512331
71MP0004742_abnormal_vestibular_system0.18613383
72MP0000432_abnormal_head_morphology0.18264004
73MP0000516_abnormal_urinary_system0.17923821
74MP0005367_renal/urinary_system_phenotyp0.17923821
75MP0005666_abnormal_adipose_tissue0.17206386
76MP0006054_spinal_hemorrhage0.16218094
77MP0004019_abnormal_vitamin_homeostasis0.15874511
78MP0001879_abnormal_lymphatic_vessel0.15801629
79MP0000462_abnormal_digestive_system0.14593450
80MP0003300_gastrointestinal_ulcer0.14184249
81MP0003935_abnormal_craniofacial_develop0.14059080
82MP0005375_adipose_tissue_phenotype0.14051238
83MP0000751_myopathy0.12211980
84MP0000604_amyloidosis0.12111345
85MP0003448_altered_tumor_morphology0.11320381
86MP0003638_abnormal_response/metabolism_0.10610597
87MP0008569_lethality_at_weaning0.10533784
88MP0002233_abnormal_nose_morphology0.10425235
89MP0009384_cardiac_valve_regurgitation0.10252390
90MP0002166_altered_tumor_susceptibility0.09649599
91MP0005193_abnormal_anterior_eye0.09532177
92MP0000013_abnormal_adipose_tissue0.09034440
93MP0000538_abnormal_urinary_bladder0.08911272
94MP0002009_preneoplasia0.08681342
95MP0002006_tumorigenesis0.08381252
96MP0000733_abnormal_muscle_development0.07640378
97MP0000747_muscle_weakness0.06924104
98MP0003045_fibrosis0.06636852
99MP0005076_abnormal_cell_differentiation0.06464706
100MP0008961_abnormal_basal_metabolism0.06407096

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.92755699
2Nail dystrophy (HP:0008404)7.33157279
3Abnormality of nail color (HP:0100643)6.11882057
4Abnormal hair laboratory examination (HP:0003328)5.60141012
5Fragile nails (HP:0001808)5.41380482
6Fine hair (HP:0002213)5.24256822
7Increased IgE level (HP:0003212)5.06297822
8Palmoplantar hyperkeratosis (HP:0000972)4.97948633
9Alopecia of scalp (HP:0002293)4.75900146
10Onycholysis (HP:0001806)4.71462731
11Palmar hyperkeratosis (HP:0010765)4.67907781
12Plantar hyperkeratosis (HP:0007556)4.49957608
13Thick nail (HP:0001805)4.38051344
14Follicular hyperkeratosis (HP:0007502)4.25358641
15Right ventricular cardiomyopathy (HP:0011663)4.15886312
16Erythema (HP:0010783)3.79611907
17Sparse eyelashes (HP:0000653)3.54009000
18Erythroderma (HP:0001019)3.40468045
19Oral leukoplakia (HP:0002745)3.39472214
20Parakeratosis (HP:0001036)3.23815092
21Amelogenesis imperfecta (HP:0000705)3.10672931
22Milia (HP:0001056)3.04733566
23Abnormality of the frontal sinuses (HP:0002687)3.04249604
24Congenital ichthyosiform erythroderma (HP:0007431)2.88596073
25Curly hair (HP:0002212)2.64300141
26Congenital, generalized hypertrichosis (HP:0004540)2.60762041
27Ridged nail (HP:0001807)2.58545037
28Intention tremor (HP:0002080)2.55780614
29Neck muscle weakness (HP:0000467)2.43592868
30Abnormal blistering of the skin (HP:0008066)2.41940530
31Aplasia cutis congenita (HP:0001057)2.39652709
32Natal tooth (HP:0000695)2.35707734
33Conjunctival hamartoma (HP:0100780)2.33757578
34Dry hair (HP:0011359)2.32194673
35Advanced eruption of teeth (HP:0006288)2.27536909
36Corneal erosion (HP:0200020)2.27438508
37Torticollis (HP:0000473)2.23749129
38Hypohidrosis (HP:0000966)2.20186480
39Palmoplantar keratoderma (HP:0000982)2.13263459
40Pruritus (HP:0000989)2.00614884
41Hypotrichosis (HP:0001006)14.9010222
42Abnormality of hair growth rate (HP:0011363)11.0753810
43Slow-growing hair (HP:0002217)11.0753810
44Woolly hair (HP:0002224)10.8524226
45Brittle hair (HP:0002299)10.3913945
46Ventricular tachycardia (HP:0004756)1.94899120
47Craniofacial dystonia (HP:0012179)1.87311201
48Difficulty walking (HP:0002355)1.84847033
49Concave nail (HP:0001598)1.82191541
50Abnormality of the pupil (HP:0000615)1.79956195
51Ventricular fibrillation (HP:0001663)1.75305571
52Abnormality of the dental root (HP:0006486)1.74635612
53Taurodontia (HP:0000679)1.74635612
54Abnormality of permanent molar morphology (HP:0011071)1.74635612
55Abnormality of dental color (HP:0011073)1.72410268
56Abnormality of molar (HP:0011077)1.71429521
57Abnormality of molar morphology (HP:0011070)1.71429521
58Focal dystonia (HP:0004373)1.70813140
59Hyporeflexia of lower limbs (HP:0002600)1.69228531
60Abnormality of the parietal bone (HP:0002696)1.69085737
61Absent eyelashes (HP:0000561)1.67380348
62Gangrene (HP:0100758)1.64532560
63Widely patent fontanelles and sutures (HP:0004492)1.62919348
64Abnormality of the neuromuscular junction (HP:0003398)1.61133283
65Fatigable weakness (HP:0003473)1.61133283
66Recurrent corneal erosions (HP:0000495)1.59684073
67Unilateral renal agenesis (HP:0000122)1.56660448
68Blepharitis (HP:0000498)1.55194999
69Abnormality of the dental pulp (HP:0006479)1.52325942
70Abnormality of placental membranes (HP:0011409)1.50885398
71Amniotic constriction ring (HP:0009775)1.50885398
72Hypergammaglobulinemia (HP:0010702)1.50066529
73Ectropion (HP:0000656)1.49070020
74Hamartoma of the eye (HP:0010568)1.47169882
75Acanthosis nigricans (HP:0000956)1.45544816
76Abnormality of the aortic arch (HP:0012303)1.45142092
77Lip pit (HP:0100267)1.44561581
78Heterogeneous (HP:0001425)1.44440109
79Sudden death (HP:0001699)1.43026029
80Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.41347016
81Round ear (HP:0100830)1.40553751
82Autoamputation (HP:0001218)1.38067721
83Distal lower limb muscle weakness (HP:0009053)1.36565905
84Carious teeth (HP:0000670)1.35174192
85Keratoconjunctivitis sicca (HP:0001097)1.33229186
86Craniofacial hyperostosis (HP:0004493)1.32692219
87Achilles tendon contracture (HP:0001771)1.29072069
88Abnormality of the fingernails (HP:0001231)1.26676078
89Type 1 muscle fiber predominance (HP:0003803)1.26298077
90Anonychia (HP:0001798)1.25851555
91Lack of skin elasticity (HP:0100679)1.24258594
92Variable expressivity (HP:0003828)1.22636972
93Increased connective tissue (HP:0009025)1.21097943
94Abnormality of the Achilles tendon (HP:0005109)1.20814967
95Widely spaced teeth (HP:0000687)1.18860371
96Neonatal onset (HP:0003623)1.17780918
97Keratoconjunctivitis (HP:0001096)1.17748229
98Sparse scalp hair (HP:0002209)1.13816790
99Atrophic scars (HP:0001075)1.13367382
100Bronchomalacia (HP:0002780)1.11059865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.21078069
2FER4.21010357
3MAPKAPK34.03014215
4ERN13.67018492
5MAP3K63.34160985
6EPHB23.01440698
7TAOK12.80644198
8MAP3K32.68521684
9LATS12.56569471
10MAP3K22.35625999
11TRIB32.32332586
12PIK3CG2.22610965
13TTN2.13088732
14RPS6KB21.87475258
15MAP3K111.84032985
16MAP2K61.80187178
17EPHB11.79520320
18BCR1.74377433
19NME11.57116552
20FGFR21.54643459
21LATS21.54381975
22EEF2K1.54051077
23FGFR11.46440385
24MST1R1.34216868
25PBK1.32769912
26MAP3K11.32348964
27FGFR41.20562217
28BMX1.20310705
29KSR21.14271755
30MAPKAPK21.11019552
31MAP2K31.07001440
32CDK61.03409656
33BLK1.01333125
34FGFR31.00398758
35RIPK10.99200103
36PDGFRA0.98951013
37MAP3K70.98644034
38MET0.98413123
39MST40.97476514
40PTK60.90781820
41RPS6KA40.90187783
42SIK10.89332626
43MAP2K10.88075625
44PTK20.88018776
45MAP3K90.86594509
46MAP2K40.79792596
47STK38L0.79698618
48LRRK20.79427622
49PAK30.78076170
50PKN20.76583675
51PRKD10.74670473
52CDK190.71184888
53OBSCN0.68324195
54STK380.68312276
55DYRK1B0.67939627
56TYRO30.65128708
57TESK10.63659060
58PIM20.60924620
59PRKCH0.59710331
60ERBB40.58249652
61NTRK20.57830124
62DDR20.57289221
63PAK20.57129360
64TRPM70.56706475
65EPHA30.55391024
66PRKCI0.54223090
67MAP2K20.53768204
68MAP3K50.53310728
69ERBB20.50640642
70RET0.47537864
71MAPKAPK50.45911386
72GSK3A0.45804569
73ICK0.45730369
74DMPK0.44659498
75PAK40.44523445
76RPS6KA10.43976921
77JAK10.43386737
78PAK60.41416905
79PHKG10.41410543
80PHKG20.41410543
81CSNK1E0.41267519
82MAPK120.39231632
83TGFBR10.37022421
84FGR0.33708053
85ERBB30.32034357
86CLK10.31382181
87FYN0.30888630
88CSNK1A1L0.29755591
89NEK10.29265029
90ILK0.29255682
91CSNK1A10.29026158
92TYK20.27940275
93NTRK10.26469099
94JAK20.26387185
95ALK0.26240657
96ROCK20.25604810
97LIMK10.25450776
98MAP3K80.24647326
99PRKACA0.24582796
100MAP3K100.24566377

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.91880950
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.91011287
3Fat digestion and absorption_Homo sapiens_hsa049753.12334785
4Fatty acid elongation_Homo sapiens_hsa000623.03704731
5Ether lipid metabolism_Homo sapiens_hsa005652.74350011
6Basal cell carcinoma_Homo sapiens_hsa052172.09107525
7Arachidonic acid metabolism_Homo sapiens_hsa005901.95826815
8Phenylalanine metabolism_Homo sapiens_hsa003601.88392352
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77109549
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71170018
11VEGF signaling pathway_Homo sapiens_hsa043701.63558917
12Melanogenesis_Homo sapiens_hsa049161.57285206
13Axon guidance_Homo sapiens_hsa043601.51517383
14Histidine metabolism_Homo sapiens_hsa003401.46213729
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.45464013
16Hedgehog signaling pathway_Homo sapiens_hsa043401.37719677
17GnRH signaling pathway_Homo sapiens_hsa049121.30781632
18Steroid biosynthesis_Homo sapiens_hsa001001.27524568
19Glioma_Homo sapiens_hsa052141.27358296
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24602302
21Bladder cancer_Homo sapiens_hsa052191.21953283
22Hippo signaling pathway_Homo sapiens_hsa043901.21027471
23Proteoglycans in cancer_Homo sapiens_hsa052051.17832831
24Tight junction_Homo sapiens_hsa045301.14096608
25Long-term potentiation_Homo sapiens_hsa047201.12793407
26Pancreatic secretion_Homo sapiens_hsa049721.11134161
27Thyroid cancer_Homo sapiens_hsa052161.10059935
28Caffeine metabolism_Homo sapiens_hsa002321.07981230
29Mineral absorption_Homo sapiens_hsa049781.03803721
30Dorso-ventral axis formation_Homo sapiens_hsa043201.02555037
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02016688
32Tyrosine metabolism_Homo sapiens_hsa003501.00265761
33Acute myeloid leukemia_Homo sapiens_hsa052211.00124389
34ECM-receptor interaction_Homo sapiens_hsa045120.99831136
35Long-term depression_Homo sapiens_hsa047300.99048426
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95199807
37Glycerophospholipid metabolism_Homo sapiens_hsa005640.94296999
38PPAR signaling pathway_Homo sapiens_hsa033200.92775429
39Phototransduction_Homo sapiens_hsa047440.92341684
40Pertussis_Homo sapiens_hsa051330.87707360
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87248374
42Estrogen signaling pathway_Homo sapiens_hsa049150.85570785
43Adherens junction_Homo sapiens_hsa045200.85162961
44beta-Alanine metabolism_Homo sapiens_hsa004100.82006382
45Ras signaling pathway_Homo sapiens_hsa040140.81532393
46Nitrogen metabolism_Homo sapiens_hsa009100.81183783
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.78592060
48Renin secretion_Homo sapiens_hsa049240.78338860
49Staphylococcus aureus infection_Homo sapiens_hsa051500.77622518
50Wnt signaling pathway_Homo sapiens_hsa043100.75042234
51Endometrial cancer_Homo sapiens_hsa052130.73383909
52Amoebiasis_Homo sapiens_hsa051460.71274686
53Gastric acid secretion_Homo sapiens_hsa049710.71252867
54Non-small cell lung cancer_Homo sapiens_hsa052230.68335669
55Salivary secretion_Homo sapiens_hsa049700.68321953
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.68276646
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68232405
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67020751
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66519865
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64927481
61Butanoate metabolism_Homo sapiens_hsa006500.60133984
62Salmonella infection_Homo sapiens_hsa051320.59921286
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54567709
64Hepatitis C_Homo sapiens_hsa051600.53638372
65Insulin resistance_Homo sapiens_hsa049310.53549411
66Oxytocin signaling pathway_Homo sapiens_hsa049210.53045293
67Fatty acid metabolism_Homo sapiens_hsa012120.51821959
68Rap1 signaling pathway_Homo sapiens_hsa040150.51724683
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51347963
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50859546
71MicroRNAs in cancer_Homo sapiens_hsa052060.50322921
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.50012882
73Gap junction_Homo sapiens_hsa045400.49929371
74Renal cell carcinoma_Homo sapiens_hsa052110.49926324
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48385003
76Focal adhesion_Homo sapiens_hsa045100.48264038
77Sphingolipid metabolism_Homo sapiens_hsa006000.47400907
78Olfactory transduction_Homo sapiens_hsa047400.47343775
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.47048085
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47038321
81Platelet activation_Homo sapiens_hsa046110.46447344
82Chemical carcinogenesis_Homo sapiens_hsa052040.45889937
83TGF-beta signaling pathway_Homo sapiens_hsa043500.45716641
84ErbB signaling pathway_Homo sapiens_hsa040120.44300871
85Protein digestion and absorption_Homo sapiens_hsa049740.43936774
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43581735
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39661890
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39355664
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39342182
90Tuberculosis_Homo sapiens_hsa051520.35510199
91Dopaminergic synapse_Homo sapiens_hsa047280.34520644
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.33465075
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32913101
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32431040
95Circadian entrainment_Homo sapiens_hsa047130.32113911
96Amphetamine addiction_Homo sapiens_hsa050310.31353598
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31255558
98Fatty acid degradation_Homo sapiens_hsa000710.31153286
99Insulin signaling pathway_Homo sapiens_hsa049100.30807673
100Prion diseases_Homo sapiens_hsa050200.30806550

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