KRTAP16-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.09703343
2adhesion of symbiont to host (GO:0044406)8.43270128
3peptide cross-linking (GO:0018149)8.22708305
4hair follicle morphogenesis (GO:0031069)7.89575566
5cell wall macromolecule catabolic process (GO:0016998)6.98129360
6cell wall macromolecule metabolic process (GO:0044036)6.98129360
7intermediate filament cytoskeleton organization (GO:0045104)6.33488524
8intermediate filament-based process (GO:0045103)6.15370809
9epidermis development (GO:0008544)6.03592016
10citrulline metabolic process (GO:0000052)5.89007663
11establishment of skin barrier (GO:0061436)5.84700433
12keratinocyte differentiation (GO:0030216)5.73267630
13hair cycle process (GO:0022405)5.18956747
14molting cycle process (GO:0022404)5.18956747
15regulation of water loss via skin (GO:0033561)5.17447558
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.14395314
17skin morphogenesis (GO:0043589)5.05281580
18linoleic acid metabolic process (GO:0043651)4.76361132
19peptidyl-arginine modification (GO:0018195)4.69785117
20tooth mineralization (GO:0034505)4.57334112
21epidermal cell differentiation (GO:0009913)4.54566835
22hemidesmosome assembly (GO:0031581)4.49437587
23keratinocyte development (GO:0003334)4.09255180
24molting cycle (GO:0042303)33.7336791
25hair cycle (GO:0042633)33.7336791
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.93993983
27long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.87146971
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66895087
29retinol metabolic process (GO:0042572)3.60896030
30defense response to fungus (GO:0050832)3.60370606
31positive regulation of uterine smooth muscle contraction (GO:0070474)3.60251007
32multicellular organismal water homeostasis (GO:0050891)3.56430450
33negative regulation of keratinocyte proliferation (GO:0010839)3.51634600
34phosphatidylinositol acyl-chain remodeling (GO:0036149)3.40787789
35negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.36250534
36alpha-linolenic acid metabolic process (GO:0036109)3.28433594
37disruption of cells of other organism (GO:0044364)3.25393811
38killing of cells of other organism (GO:0031640)3.25393811
39actin nucleation (GO:0045010)3.21020092
40positive regulation of chemokine secretion (GO:0090197)3.19748229
41positive regulation of hair cycle (GO:0042635)3.19463280
42positive regulation of hair follicle development (GO:0051798)3.19463280
43hair follicle development (GO:0001942)3.18498450
44regulation of natural killer cell differentiation (GO:0032823)3.16290586
45tachykinin receptor signaling pathway (GO:0007217)3.10130614
46phosphatidylserine acyl-chain remodeling (GO:0036150)3.07525613
47regulation of keratinocyte differentiation (GO:0045616)3.01031176
48regulation of hair follicle development (GO:0051797)2.95883279
49bone trabecula formation (GO:0060346)2.94703022
50positive regulation of meiotic cell cycle (GO:0051446)2.92447568
51fatty acid elongation (GO:0030497)2.90953964
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.89971095
53water homeostasis (GO:0030104)2.89573320
54regulation of defense response to virus by host (GO:0050691)2.89257087
55sequestering of actin monomers (GO:0042989)2.87217499
56lipoxygenase pathway (GO:0019372)2.86434253
57epithelium development (GO:0060429)2.86382052
58fatty-acyl-CoA metabolic process (GO:0035337)2.86153910
59phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.86048225
60keratinocyte proliferation (GO:0043616)2.84219621
61thioester biosynthetic process (GO:0035384)2.83594058
62acyl-CoA biosynthetic process (GO:0071616)2.83594058
63ectoderm development (GO:0007398)2.82769176
64regulation of chemokine secretion (GO:0090196)2.81949730
65regulation of uterine smooth muscle contraction (GO:0070472)2.77623612
66negative regulation of protein localization to plasma membrane (GO:1903077)2.72714925
67negative regulation of T cell apoptotic process (GO:0070233)2.72588664
68positive regulation of epidermis development (GO:0045684)2.70193757
69regulation of hair cycle (GO:0042634)2.68547255
70response to fungus (GO:0009620)2.67795408
71atrioventricular valve morphogenesis (GO:0003181)2.67585665
72negative regulation of stress fiber assembly (GO:0051497)2.66310797
73gap junction assembly (GO:0016264)2.58529916
74primary alcohol metabolic process (GO:0034308)2.57919382
75positive regulation of interleukin-4 production (GO:0032753)2.56267897
76long-chain fatty acid biosynthetic process (GO:0042759)2.53084930
77positive regulation of lamellipodium assembly (GO:0010592)2.48983555
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.48268766
79regulation of mesenchymal cell apoptotic process (GO:2001053)2.44290989
80negative regulation of cell fate specification (GO:0009996)2.40395530
81ventricular cardiac muscle cell action potential (GO:0086005)2.40374419
82epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.39351407
83phosphatidylserine metabolic process (GO:0006658)2.38088745
84lymph vessel development (GO:0001945)2.38008738
85positive regulation of natural killer cell differentiation (GO:0032825)2.37704083
86regulation of epidermal cell differentiation (GO:0045604)2.36583886
87positive regulation of gamma-delta T cell activation (GO:0046645)2.34708077
88regulation of gamma-delta T cell differentiation (GO:0045586)2.34396738
89positive regulation of interleukin-17 production (GO:0032740)2.33637639
90phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.32330692
91regulation of epidermis development (GO:0045682)2.30683258
92positive T cell selection (GO:0043368)2.29165160
93myotube differentiation (GO:0014902)2.28879023
94regulation of sequestering of triglyceride (GO:0010889)2.27948675
95negative regulation of glial cell proliferation (GO:0060253)2.27230779
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.26985442
97negative T cell selection (GO:0043383)2.26125262
98positive regulation of T cell cytokine production (GO:0002726)2.24699524
99regulation of secondary heart field cardioblast proliferation (GO:0003266)2.23742781
100regulation of cardioblast proliferation (GO:0003264)2.23742781
101outflow tract septum morphogenesis (GO:0003148)2.22710471
102positive regulation of keratinocyte differentiation (GO:0045618)2.21834553
103cell surface receptor signaling pathway involved in heart development (GO:0061311)2.21728092
104positive regulation of epidermal cell differentiation (GO:0045606)2.20974309
105regulation of transmission of nerve impulse (GO:0051969)2.19066194
106natural killer cell differentiation (GO:0001779)2.15168464
107regulation of cardioblast differentiation (GO:0051890)2.14809302
108skin development (GO:0043588)2.14234667
109wound healing, spreading of epidermal cells (GO:0035313)2.13897460
110regulation of heart rate by cardiac conduction (GO:0086091)2.12678152
111positive thymic T cell selection (GO:0045059)2.11291966
112detection of bacterium (GO:0016045)2.07929637
113cranial suture morphogenesis (GO:0060363)2.05958588
114phosphatidylcholine acyl-chain remodeling (GO:0036151)2.04770992
115regulation of defense response to virus by virus (GO:0050690)2.04486392
116tolerance induction (GO:0002507)2.04286957
117cell communication involved in cardiac conduction (GO:0086065)2.03996124
118negative regulation of actin filament bundle assembly (GO:0032232)2.01645360
119positive regulation of monocyte chemotaxis (GO:0090026)2.00934780
120regulation of keratinocyte proliferation (GO:0010837)2.00673309
121intermediate filament organization (GO:0045109)11.6299367
122keratinization (GO:0031424)10.9718847
123desmosome organization (GO:0002934)10.1883203
124adhesion of symbiont to host cell (GO:0044650)10.0495094
125virion attachment to host cell (GO:0019062)10.0495094
126triglyceride biosynthetic process (GO:0019432)1.99239111
127leukocyte aggregation (GO:0070486)1.99008166
128regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.98056646
129respiratory burst (GO:0045730)1.97313786
130epithelial cell-cell adhesion (GO:0090136)1.97033689
131aging (GO:0007568)1.96143182
132coronary vasculature morphogenesis (GO:0060977)1.96122007
133positive regulation of protein homodimerization activity (GO:0090073)1.95997759
134regulation of ruffle assembly (GO:1900027)1.95456327
135cytoskeletal anchoring at plasma membrane (GO:0007016)1.94929008
136T cell receptor signaling pathway (GO:0050852)1.93195632
137negative regulation of epidermis development (GO:0045683)1.92454502
138regulation of gamma-delta T cell activation (GO:0046643)1.91392284
139detection of other organism (GO:0098543)1.90656633
140planar cell polarity pathway involved in neural tube closure (GO:0090179)1.90518942
141positive regulation of lamellipodium organization (GO:1902745)1.88701815
142non-canonical Wnt signaling pathway (GO:0035567)1.87940781
143neutral lipid biosynthetic process (GO:0046460)1.87154588
144acylglycerol biosynthetic process (GO:0046463)1.87154588
145negative thymic T cell selection (GO:0045060)1.84708749
146regulation of T cell receptor signaling pathway (GO:0050856)1.83879532
147regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450911.82320958
148response to interferon-beta (GO:0035456)1.79996049
149long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.79786664
150cellular response to interferon-beta (GO:0035458)1.79003152
151regulation of interleukin-4 production (GO:0032673)1.78525652
152positive regulation of T cell differentiation in thymus (GO:0033089)1.77811194
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.77064361
154cellular zinc ion homeostasis (GO:0006882)1.76969800
155cardiac right ventricle morphogenesis (GO:0003215)1.76703143
156alditol phosphate metabolic process (GO:0052646)1.73517191
157very long-chain fatty acid metabolic process (GO:0000038)1.72861518
158regulation of skeletal muscle cell differentiation (GO:2001014)1.71800963
159ephrin receptor signaling pathway (GO:0048013)1.70743361
160G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.69421367
161negative regulation of cell fate commitment (GO:0010454)1.67795954
162fatty-acyl-CoA biosynthetic process (GO:0046949)1.66394619
163Golgi transport vesicle coating (GO:0048200)1.65967962
164COPI coating of Golgi vesicle (GO:0048205)1.65967962
165oocyte development (GO:0048599)1.65614520
166cardiac conduction (GO:0061337)1.65488484
167muscle organ morphogenesis (GO:0048644)1.64764026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.87153059
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.80069558
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.46559502
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06627823
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67413937
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47950767
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36583903
8CTCF_20526341_ChIP-Seq_ESCs_Human2.24209819
9NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.23497235
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.16541645
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.13710282
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10082318
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09263654
14BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.06389430
15TP63_17297297_ChIP-ChIP_HaCaT_Human12.2087135
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96430455
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89272335
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79078357
19SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75133548
20E2F1_20622854_ChIP-Seq_HELA_Human1.73505399
21EGR1_19032775_ChIP-ChIP_M12_Human1.73493441
22TAF2_19829295_ChIP-Seq_ESCs_Human1.71462580
23P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.69771799
24CTCF_27219007_Chip-Seq_Bcells_Human1.65968222
25NANOG_20526341_ChIP-Seq_ESCs_Human1.62640248
26EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61951949
27CSB_26484114_Chip-Seq_FIBROBLAST_Human1.60409275
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.59272693
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.58747531
30RUNX_20019798_ChIP-Seq_JUKART_Human1.57471530
31ERG_20517297_ChIP-Seq_VCAP_Human1.56397441
32P53_21459846_ChIP-Seq_SAOS-2_Human1.54272068
33LXR_22292898_ChIP-Seq_THP-1_Human1.50449226
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45772286
35RACK7_27058665_Chip-Seq_MCF-7_Human1.45734826
36MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.45473288
37TP63_22573176_ChIP-Seq_HFKS_Human1.42862267
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40648665
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40648665
40GATA3_27048872_Chip-Seq_THYMUS_Human1.40015478
41YY1_22570637_ChIP-Seq_MALME-3M_Human1.39106615
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37659018
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.35614036
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34348860
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.34348860
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33603541
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31028595
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30577173
49ATF3_27146783_Chip-Seq_COLON_Human1.29709737
50VDR_22108803_ChIP-Seq_LS180_Human1.28570864
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28264817
52UTX_26944678_Chip-Seq_JUKART_Human1.27925298
53MYB_26560356_Chip-Seq_TH2_Human1.25505108
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25498097
55BCL6_27268052_Chip-Seq_Bcells_Human1.24483266
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.24460830
57HTT_18923047_ChIP-ChIP_STHdh_Human1.20669066
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19729294
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19502912
60AHR_22903824_ChIP-Seq_MCF-7_Human1.18937787
61BCOR_27268052_Chip-Seq_Bcells_Human1.18593260
62PHF8_20622854_ChIP-Seq_HELA_Human1.18054797
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.17721300
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.17465942
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16229876
66RAC3_21632823_ChIP-Seq_H3396_Human1.15067221
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14829984
68ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14739927
69RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14424756
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13744478
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13190755
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12612592
73P300_27268052_Chip-Seq_Bcells_Human1.11855597
74GATA4_25053715_ChIP-Seq_YYC3_Human1.11056869
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10768647
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.10151879
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.09898066
78E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09657451
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08709436
80SMC4_20622854_ChIP-Seq_HELA_Human1.07769410
81SA1_27219007_Chip-Seq_Bcells_Human1.07241140
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06799653
83TP53_18474530_ChIP-ChIP_U2OS_Human1.06584428
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.05998856
85TP63_23658742_ChIP-Seq_EP156T_Human1.05278396
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.04555865
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03407766
88CEBPB_22108803_ChIP-Seq_LS180_Human1.02833898
89P68_20966046_ChIP-Seq_HELA_Human1.02243879
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02051039
91SOX2_21211035_ChIP-Seq_LN229_Human1.00823768
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.99581772
93MYC_19829295_ChIP-Seq_ESCs_Human0.99398852
94RXR_22108803_ChIP-Seq_LS180_Human0.98432878
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98094959
96P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97075314
97GATA3_26560356_Chip-Seq_TH2_Human0.96728710
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96247342
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96163679
100KLF5_25053715_ChIP-Seq_YYC3_Human0.96022910
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95885281
102EZH2_27294783_Chip-Seq_ESCs_Mouse0.94799373
103GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94632896
104ERA_21632823_ChIP-Seq_H3396_Human0.94159784
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.93819104
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93571681
107FOXH1_21741376_ChIP-Seq_ESCs_Human0.93199448
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93152374
109SOX2_20726797_ChIP-Seq_SW620_Human0.92679284
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91919109
111BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90573319
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90454598
113FOXH1_21741376_ChIP-Seq_EPCs_Human0.89492817
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89267264
115IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88949935
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88940119
117RNF2_27304074_Chip-Seq_ESCs_Mouse0.88790540
118GATA6_21074721_ChIP-Seq_CACO-2_Human0.88039558
119MAF_26560356_Chip-Seq_TH2_Human0.87995174
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87439956
121EZH2_27304074_Chip-Seq_ESCs_Mouse0.87130002
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.87079754
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86614408
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86423073
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85001221
126MYB_26560356_Chip-Seq_TH1_Human0.84971488
127SPI1_20517297_ChIP-Seq_HL60_Human0.84513771
128GATA3_26560356_Chip-Seq_TH1_Human0.83850198
129OCT4_20526341_ChIP-Seq_ESCs_Human0.83596808
130GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83031939
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.79751496
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79513544
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.79425764
134PHF8_20622853_ChIP-Seq_HELA_Human0.79396044
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78485443
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77756426
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77408862
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76594769
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76036111
140AR_21572438_ChIP-Seq_LNCaP_Human0.75824532
141ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75685353
142HNFA_21074721_ChIP-Seq_CACO-2_Human0.75681908
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75636199
144TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75389031
145RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75253605
146FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.74198127
147STAT1_20625510_ChIP-Seq_HELA_Human0.73701326
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72832134
149MAF_26560356_Chip-Seq_TH1_Human0.72363056
150KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71308982
151NCOR_22424771_ChIP-Seq_293T_Human0.70838505
152AR_20517297_ChIP-Seq_VCAP_Human0.69992087
153RBPJ_21746931_ChIP-Seq_IB4_Human0.69796406
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69407584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.59078769
2MP0002098_abnormal_vibrissa_morphology7.12182717
3MP0000647_abnormal_sebaceous_gland6.42338098
4MP0002796_impaired_skin_barrier6.08250534
5MP0010234_abnormal_vibrissa_follicle5.38548246
6MP0005275_abnormal_skin_tensile5.18442475
7MP0000383_abnormal_hair_follicle4.44912173
8MP0000377_abnormal_hair_follicle4.05287301
9MP0010678_abnormal_skin_adnexa4.02714755
10MP0005501_abnormal_skin_physiology3.74701148
11MP0000427_abnormal_hair_cycle3.63310111
12MP0009379_abnormal_foot_pigmentation3.45925286
13MP0003705_abnormal_hypodermis_morpholog3.45901017
14MP0002254_reproductive_system_inflammat2.88000937
15MP0001216_abnormal_epidermal_layer2.64563276
16MP0003878_abnormal_ear_physiology2.52237545
17MP0005377_hearing/vestibular/ear_phenot2.52237545
18MP0004381_abnormal_hair_follicle2.46166555
19MP0000367_abnormal_coat/_hair2.39682145
20MP0010771_integument_phenotype2.29669893
21MP0004947_skin_inflammation2.27258052
22MP0001243_abnormal_dermal_layer2.21156069
23MP0002060_abnormal_skin_morphology2.20761851
24MP0002234_abnormal_pharynx_morphology2.09178296
25MP0003453_abnormal_keratinocyte_physiol2.06690620
26MP0005671_abnormal_response_to1.78878104
27MP0003011_delayed_dark_adaptation1.71728139
28MP0005409_darkened_coat_color1.59750408
29MP0002166_altered_tumor_susceptibility1.57009720
30MP0000467_abnormal_esophagus_morphology1.53592224
31MP0009931_abnormal_skin_appearance1.46045048
32MP0000762_abnormal_tongue_morphology1.41832858
33MP0003566_abnormal_cell_adhesion1.31781379
34MP0006035_abnormal_mitochondrial_morpho1.24068176
35MP0009053_abnormal_anal_canal1.23099574
36MP0005647_abnormal_sex_gland1.15857082
37MP0002006_tumorigenesis1.14272898
38MP0009333_abnormal_splenocyte_physiolog1.06927781
39MP0000685_abnormal_immune_system1.04227922
40MP0003941_abnormal_skin_development1.00754927
41MP0001191_abnormal_skin_condition0.98058822
42MP0004185_abnormal_adipocyte_glucose0.91722480
43MP0004885_abnormal_endolymph0.90684848
44MP0004264_abnormal_extraembryonic_tissu0.85214000
45MP0005000_abnormal_immune_tolerance0.83171813
46MP0002877_abnormal_melanocyte_morpholog0.81252518
47MP0002095_abnormal_skin_pigmentation0.81200324
48MP0003646_muscle_fatigue0.81037483
49MP0005379_endocrine/exocrine_gland_phen0.79741897
50MP0001800_abnormal_humoral_immune0.79184015
51MP0001851_eye_inflammation0.78774897
52MP0003436_decreased_susceptibility_to0.78184219
53MP0005387_immune_system_phenotype0.76566737
54MP0001790_abnormal_immune_system0.76566737
55MP0001661_extended_life_span0.75502493
56MP0005025_abnormal_response_to0.74266607
57MP0003724_increased_susceptibility_to0.72881233
58MP0001346_abnormal_lacrimal_gland0.71365640
59MP0002933_joint_inflammation0.70533552
60MP0001348_abnormal_lacrimal_gland0.68537511
61MP0001340_abnormal_eyelid_morphology0.67979366
62MP0001835_abnormal_antigen_presentation0.66126221
63MP0005464_abnormal_platelet_physiology0.65626471
64MP0002723_abnormal_immune_serum0.62936647
65MP0002420_abnormal_adaptive_immunity0.62815556
66MP0008438_abnormal_cutaneous_collagen0.62550898
67MP0002148_abnormal_hypersensitivity_rea0.62445663
68MP0000678_abnormal_parathyroid_gland0.62439377
69MP0005174_abnormal_tail_pigmentation0.62032137
70MP0005535_abnormal_body_temperature0.61510294
71MP0001819_abnormal_immune_cell0.61472249
72MP0004043_abnormal_pH_regulation0.60710103
73MP0001849_ear_inflammation0.57350878
74MP0000566_synostosis0.57146209
75MP0001873_stomach_inflammation0.56593322
76MP0000013_abnormal_adipose_tissue0.54769166
77MP0000015_abnormal_ear_pigmentation0.53927623
78MP0002970_abnormal_white_adipose0.53065686
79MP0003315_abnormal_perineum_morphology0.51711873
80MP0009785_altered_susceptibility_to0.50808815
81MP0000627_abnormal_mammary_gland0.49911520
82MP0002452_abnormal_antigen_presenting0.49168663
83MP0001533_abnormal_skeleton_physiology0.48598112
84MP0010030_abnormal_orbit_morphology0.47534815
85MP0003755_abnormal_palate_morphology0.47520626
86MP0001919_abnormal_reproductive_system0.46816027
87MP0001784_abnormal_fluid_regulation0.45247553
88MP0001485_abnormal_pinna_reflex0.45122028
89MP0002277_abnormal_respiratory_mucosa0.44632278
90MP0002249_abnormal_larynx_morphology0.44404904
91MP0005075_abnormal_melanosome_morpholog0.41230089
92MP0003191_abnormal_cellular_cholesterol0.40954551
93MP0002282_abnormal_trachea_morphology0.40675359
94MP0002837_dystrophic_cardiac_calcinosis0.40095851
95MP0000716_abnormal_immune_system0.39123312
96MP0010155_abnormal_intestine_physiology0.38910136
97MP0002722_abnormal_immune_system0.38750868
98MP0001905_abnormal_dopamine_level0.38526806
99MP0002177_abnormal_outer_ear0.37717727
100MP0005023_abnormal_wound_healing0.37540165
101MP0003300_gastrointestinal_ulcer0.37471090
102MP0002132_abnormal_respiratory_system0.35341945
103MP0000703_abnormal_thymus_morphology0.35129334
104MP0005451_abnormal_body_composition0.35049462
105MP0002398_abnormal_bone_marrow0.33559356
106MP0006072_abnormal_retinal_apoptosis0.33456288
107MP0008961_abnormal_basal_metabolism0.33405889
108MP0004130_abnormal_muscle_cell0.33389267
109MP0002111_abnormal_tail_morphology0.33166704
110MP0002419_abnormal_innate_immunity0.31027211
111MP0003786_premature_aging0.30420115
112MP0000003_abnormal_adipose_tissue0.28399025
113MP0001765_abnormal_ion_homeostasis0.28141031
114MP0000465_gastrointestinal_hemorrhage0.26996077
115MP0004272_abnormal_basement_membrane0.26974808
116MP0009840_abnormal_foam_cell0.26726611
117MP0005375_adipose_tissue_phenotype0.26577730
118MP0003763_abnormal_thymus_physiology0.26288952
119MP0002163_abnormal_gland_morphology0.26098974
120MP0002405_respiratory_system_inflammati0.25780176
121MP0003385_abnormal_body_wall0.25620083
122MP0002909_abnormal_adrenal_gland0.25318168
123MP0003283_abnormal_digestive_organ0.24916162
124MP0001984_abnormal_olfaction0.24404313
125MP0004019_abnormal_vitamin_homeostasis0.23974949
126MP0001845_abnormal_inflammatory_respons0.23974858
127MP0003866_abnormal_defecation0.22962713
128MP0003950_abnormal_plasma_membrane0.22745901
129MP0006054_spinal_hemorrhage0.21650026
130MP0000462_abnormal_digestive_system0.20854084
131MP0005248_abnormal_Harderian_gland0.20153361
132MP0000537_abnormal_urethra_morphology0.18883507
133MP0002697_abnormal_eye_size0.18127393
134MP0010352_gastrointestinal_tract_polyps0.17792726
135MP0000432_abnormal_head_morphology0.16579238
136MP0003329_amyloid_beta_deposits0.15105565
137MP0001879_abnormal_lymphatic_vessel0.14504122
138MP0005452_abnormal_adipose_tissue0.14488235
139MP0005076_abnormal_cell_differentiation0.14428529
140MP0000516_abnormal_urinary_system0.13384387
141MP0005367_renal/urinary_system_phenotyp0.13384387
142MP0003935_abnormal_craniofacial_develop0.13260407
143MP0005666_abnormal_adipose_tissue0.12754727
144MP0003806_abnormal_nucleotide_metabolis0.12056446
145MP0003045_fibrosis0.11557593
146MP0004858_abnormal_nervous_system0.11113972
147MP0002896_abnormal_bone_mineralization0.10934429
148MP0000750_abnormal_muscle_regeneration0.10783092
149MP0004742_abnormal_vestibular_system0.10262768
150MP0000538_abnormal_urinary_bladder0.09927683
151MP0005508_abnormal_skeleton_morphology0.07510938
152MP0001756_abnormal_urination0.06634580
153MP0000747_muscle_weakness0.05808594
154MP0003638_abnormal_response/metabolism_0.05520016
155MP0002139_abnormal_hepatobiliary_system0.05422445
156MP0001188_hyperpigmentation0.05059417

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.97475721
2Pili torti (HP:0003777)9.93753359
3Nail dystrophy (HP:0008404)6.98225072
4Abnormal hair laboratory examination (HP:0003328)6.32563186
5Abnormality of nail color (HP:0100643)6.01369101
6Fragile nails (HP:0001808)5.57300569
7Absent eyebrow (HP:0002223)5.56876269
8Increased IgE level (HP:0003212)5.13139412
9Onycholysis (HP:0001806)5.08872430
10Fine hair (HP:0002213)5.02226953
11Palmoplantar hyperkeratosis (HP:0000972)4.82546579
12Absent hair (HP:0002298)4.81309930
13Alopecia of scalp (HP:0002293)4.69912281
14Palmar hyperkeratosis (HP:0010765)4.54239221
15Plantar hyperkeratosis (HP:0007556)4.36141290
16Right ventricular cardiomyopathy (HP:0011663)4.22621197
17Follicular hyperkeratosis (HP:0007502)4.22420666
18Thick nail (HP:0001805)4.15614629
19Abnormality of secondary sexual hair (HP:0009888)3.99437170
20Abnormality of the axillary hair (HP:0100134)3.99437170
21Erythema (HP:0010783)3.81675452
22Sparse eyelashes (HP:0000653)3.52702046
23Amelogenesis imperfecta (HP:0000705)3.45782555
24Abnormality of the frontal sinuses (HP:0002687)3.37345893
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.23312271
26Elevated erythrocyte sedimentation rate (HP:0003565)3.20574302
27Oral leukoplakia (HP:0002745)3.11652591
28Milia (HP:0001056)3.01271050
29Curly hair (HP:0002212)3.00079538
30Erythroderma (HP:0001019)2.96547097
31Parakeratosis (HP:0001036)2.64725798
32Congenital, generalized hypertrichosis (HP:0004540)2.62061376
33Aplasia cutis congenita (HP:0001057)2.55091463
34Dry hair (HP:0011359)2.52715676
35Ridged nail (HP:0001807)2.51403064
36Intention tremor (HP:0002080)2.47587212
37Natal tooth (HP:0000695)2.45268420
38Neck muscle weakness (HP:0000467)2.42039207
39Advanced eruption of teeth (HP:0006288)2.35025829
40Abnormal blistering of the skin (HP:0008066)2.33685484
41Congenital ichthyosiform erythroderma (HP:0007431)2.33131998
42Torticollis (HP:0000473)2.22229498
43Corneal erosion (HP:0200020)2.15360959
44Hypohidrosis (HP:0000966)2.12982079
45Abnormality of dental color (HP:0011073)2.11916950
46Unilateral renal agenesis (HP:0000122)2.06014767
47Ventricular tachycardia (HP:0004756)2.03545685
48Hypotrichosis (HP:0001006)14.3398847
49Woolly hair (HP:0002224)11.1893673
50Slow-growing hair (HP:0002217)10.6240855
51Abnormality of hair growth rate (HP:0011363)10.6240855
52Palmoplantar keratoderma (HP:0000982)1.97444519
53Pruritus (HP:0000989)1.92137499
54Widely patent fontanelles and sutures (HP:0004492)1.91088026
55Difficulty walking (HP:0002355)1.89040310
56Abnormality of the pupil (HP:0000615)1.87632020
57Craniofacial dystonia (HP:0012179)1.86097692
58Seborrheic dermatitis (HP:0001051)1.83277641
59Taurodontia (HP:0000679)1.80895780
60Abnormality of permanent molar morphology (HP:0011071)1.80895780
61Abnormality of the dental root (HP:0006486)1.80895780
62Ventricular fibrillation (HP:0001663)1.80261826
63Abnormality of molar morphology (HP:0011070)1.80000862
64Abnormality of molar (HP:0011077)1.80000862
65Pustule (HP:0200039)1.79916553
66Concave nail (HP:0001598)1.79689652
67Abnormality of the parietal bone (HP:0002696)1.75833450
68Conjunctival hamartoma (HP:0100780)1.75462645
69Hyporeflexia of lower limbs (HP:0002600)1.74227838
70Focal dystonia (HP:0004373)1.71589485
71Absent eyelashes (HP:0000561)1.69705623
72Abnormality of the dental pulp (HP:0006479)1.67962459
73Urticaria (HP:0001025)1.63229586
74Myositis (HP:0100614)1.62275043
75Abnormality of the aortic arch (HP:0012303)1.59736928
76Recurrent corneal erosions (HP:0000495)1.57874959
77Craniofacial hyperostosis (HP:0004493)1.57796722
78Sudden death (HP:0001699)1.57313353
79Furrowed tongue (HP:0000221)1.56966822
80Coarse hair (HP:0002208)1.56771823
81Hamartoma of the eye (HP:0010568)1.55338327
82Hypergammaglobulinemia (HP:0010702)1.52834022
83Round ear (HP:0100830)1.52121600
84Acanthosis nigricans (HP:0000956)1.51846782
85Lip pit (HP:0100267)1.50022697
86Severe combined immunodeficiency (HP:0004430)1.49921338
87Recurrent bacterial skin infections (HP:0005406)1.49601377
88Abnormality of the neuromuscular junction (HP:0003398)1.45707316
89Fatigable weakness (HP:0003473)1.45707316
90Ulnar deviation of the wrist (HP:0003049)1.44402293
91Blepharitis (HP:0000498)1.43521072
92Carious teeth (HP:0000670)1.43283434
93Eczematoid dermatitis (HP:0000976)1.42834332
94Type 1 muscle fiber predominance (HP:0003803)1.41332811
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.40911416
96Abnormality of placental membranes (HP:0011409)1.38818313
97Amniotic constriction ring (HP:0009775)1.38818313
98Abnormality of the salivary glands (HP:0010286)1.38383196
99Heterogeneous (HP:0001425)1.35001376
100IgG deficiency (HP:0004315)1.34491300
101Widely spaced teeth (HP:0000687)1.32943570
102Anonychia (HP:0001798)1.31685274
103Abnormality of B cell number (HP:0010975)1.30799279
104Keratoconjunctivitis sicca (HP:0001097)1.28730328
105Central scotoma (HP:0000603)1.27873151
106B lymphocytopenia (HP:0010976)1.27862949
107T lymphocytopenia (HP:0005403)1.27851075
108Distal lower limb muscle weakness (HP:0009053)1.26584818
109Autoamputation (HP:0001218)1.25022982
110Hyperhidrosis (HP:0000975)1.24868744
111Abnormality of the fingernails (HP:0001231)1.23984780
112Hyperthyroidism (HP:0000836)1.23614718
113Cranial hyperostosis (HP:0004437)1.23226946
114Wide cranial sutures (HP:0010537)1.23048542
115Laryngomalacia (HP:0001601)1.22494523
116Recurrent skin infections (HP:0001581)1.22414432
117Increased connective tissue (HP:0009025)1.22064452
118Ectropion (HP:0000656)1.21410348
119Gangrene (HP:0100758)1.21044593
120Sparse scalp hair (HP:0002209)1.20462585
121Distal arthrogryposis (HP:0005684)1.20067665
122Multifactorial inheritance (HP:0001426)1.19442042
123Mildly elevated creatine phosphokinase (HP:0008180)1.19174948
124Abnormality of the gastric mucosa (HP:0004295)1.18233274
125Stomatitis (HP:0010280)1.17528158
126IgM deficiency (HP:0002850)1.17013155
127Achilles tendon contracture (HP:0001771)1.16451861
128Autoimmune hemolytic anemia (HP:0001890)1.15489787
129Lack of skin elasticity (HP:0100679)1.15255875
130Abnormality of T cell number (HP:0011839)1.14877472
131Skin ulcer (HP:0200042)1.10710705
132Combined immunodeficiency (HP:0005387)1.09906414
133Papilloma (HP:0012740)1.09587322
134Verrucae (HP:0200043)1.09587322
135Abnormal rod and cone electroretinograms (HP:0008323)1.07474406
136Conical tooth (HP:0000698)1.04590304
137Neonatal onset (HP:0003623)1.02642444
138Dyschromatopsia (HP:0007641)0.98830052
139Cerebral palsy (HP:0100021)0.96877593
140Eosinophilia (HP:0001880)0.94557398
141Abnormality of T cells (HP:0002843)0.91749527
142Skin rash (HP:0000988)0.90478092
143Abnormality of eosinophils (HP:0001879)0.88536609
144Aplastic anemia (HP:0001915)0.86510750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.72427764
2KDR4.40907056
3FER4.15445723
4EPHA23.98568530
5MAPKAPK33.97324671
6LIMK13.62899538
7PIK3CG3.45328382
8MAP3K63.35905946
9ERN13.30008502
10TLK13.16063520
11PRPF4B2.98343265
12EPHB22.85883225
13SCYL22.72512924
14TAOK12.58977704
15TRIB32.45514928
16MAP3K22.43494307
17MAP3K32.31336978
18WNK42.25425510
19ZAP702.19442158
20VRK22.18411409
21BCKDK2.03426770
22ZAK1.91696748
23TTN1.90684369
24ADRBK21.87741782
25LATS11.77027618
26PDK31.74704458
27PDK41.74704458
28RIPK11.74301296
29FES1.72220870
30PINK11.66478718
31MAP3K111.64247848
32VRK11.62842745
33RIPK41.62656969
34GRK61.54335662
35RPS6KB21.53337692
36ITK1.50939932
37MAP3K11.50208229
38BCR1.45878843
39KSR21.45235576
40OBSCN1.44185347
41TEC1.39907145
42STK391.37631843
43MYLK1.36469099
44EPHB11.32814937
45TAOK21.32183038
46EEF2K1.31157291
47MAPK151.30970426
48MAP3K91.28400353
49MST1R1.23756345
50EIF2AK31.22203891
51MAP3K121.20159078
52LCK1.19335959
53TRPM71.16294311
54MAPKAPK51.12800121
55MAP2K61.12056023
56PDK21.10401859
57LATS21.10031468
58MAP3K51.09929751
59TAOK31.07508954
60SYK1.07094465
61FGFR21.06881137
62NME11.06357270
63INSRR1.05840879
64CDK61.01168530
65MAPKAPK21.00789644
66TBK11.00755059
67MAPK110.99971567
68MAP4K10.99347174
69PDGFRA0.99176369
70FGFR40.98790462
71DYRK1B0.97072789
72MET0.95813761
73TXK0.91892413
74TGFBR10.91138377
75BTK0.89753144
76BMX0.88813233
77PTK20.88570538
78PTK60.88347891
79MAP2K30.86349269
80FGFR10.83678220
81BLK0.82201059
82FGFR30.80685483
83JAK10.80384369
84PRKCI0.80175833
85SIK10.79814873
86MAPK120.79700923
87OXSR10.79672601
88PRKD10.79166834
89MAP2K10.79018191
90RPS6KA50.78962630
91STK240.78918459
92TRIM280.78530723
93SMG10.77855877
94HIPK20.77319543
95PRKCQ0.77011619
96CDC42BPA0.75927129
97MAP2K40.74323698
98TNK20.73926796
99RPS6KA40.73426260
100PRKCH0.73422973
101CSNK1A1L0.73358194
102GRK70.71103047
103DAPK30.70740667
104SGK30.69282956
105FRK0.69250957
106PRKD30.66914019
107PIM20.66776199
108NTRK10.64663656
109PAK30.64506850
110MAP3K70.63870142
111EIF2AK10.63288326
112PASK0.61964417
113ROCK10.61591650
114EPHA30.60873148
115DAPK10.60259089
116PDPK10.59920596
117PHKG20.58698283
118PHKG10.58698283
119PKN10.56908038
120HCK0.56640373
121GSK3A0.55217136
122PKN20.55057323
123PDGFRB0.51102854
124MAP2K20.50042910
125STK380.46238549
126STK38L0.45668299
127ARAF0.45505452
128GRK50.44709007
129RET0.44181029
130ERBB20.43991005
131MAP3K100.43502511
132JAK20.43137218
133WNK30.42021274
134TAF10.40269935
135ERBB40.40269139
136IKBKB0.40186547
137LMTK20.39924495
138ADRBK10.39502633
139IKBKE0.39189661
140LRRK20.38038401
141PIM10.36741710
142LYN0.36710767
143PBK0.36625592
144PAK60.35704941
145SGK10.35670138
146ERBB30.35484291
147UHMK10.35306278
148CLK10.34989787
149RPS6KA10.34891142
150TESK10.33670515
151GRK10.32967827
152MTOR0.32934375
153CSNK1A10.32895248
154CSNK1G10.32607563
155PAK40.32544167
156DDR20.31305212
157CDK190.31057735
158TYK20.30443555
159CSK0.29641796
160PAK20.28995033
161PDK10.28339898
162PRKACA0.27316320
163INSR0.26907135
164CAMKK10.25529954
165MAPK70.24190001
166PRKCA0.20062706
167BUB10.19920668
168FYN0.19403432
169KIT0.18296630
170TYRO30.17271467
171CDK40.16128043
172NLK0.15731702
173MAPK30.14533893

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.57680233
2Linoleic acid metabolism_Homo sapiens_hsa005914.57379322
3Primary immunodeficiency_Homo sapiens_hsa053404.09001401
4Proteasome_Homo sapiens_hsa030503.64022792
5Vitamin digestion and absorption_Homo sapiens_hsa049773.46138474
6Fat digestion and absorption_Homo sapiens_hsa049752.87901029
7Fatty acid elongation_Homo sapiens_hsa000622.82429163
8Antigen processing and presentation_Homo sapiens_hsa046122.48433579
9Ether lipid metabolism_Homo sapiens_hsa005652.41224818
10T cell receptor signaling pathway_Homo sapiens_hsa046602.15124996
11Basal cell carcinoma_Homo sapiens_hsa052172.09289373
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.01225582
13Phenylalanine metabolism_Homo sapiens_hsa003601.90965098
14Melanogenesis_Homo sapiens_hsa049161.82470720
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.78803515
16Arachidonic acid metabolism_Homo sapiens_hsa005901.73215971
17Oxidative phosphorylation_Homo sapiens_hsa001901.72296503
18Retinol metabolism_Homo sapiens_hsa008301.64541437
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.56448710
20Hematopoietic cell lineage_Homo sapiens_hsa046401.55695981
21Fatty acid biosynthesis_Homo sapiens_hsa000611.51131466
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49515017
23Parkinsons disease_Homo sapiens_hsa050121.36708808
24Histidine metabolism_Homo sapiens_hsa003401.36008427
25Axon guidance_Homo sapiens_hsa043601.31328129
26VEGF signaling pathway_Homo sapiens_hsa043701.29740705
27Alzheimers disease_Homo sapiens_hsa050101.29030098
28Pancreatic secretion_Homo sapiens_hsa049721.28551750
29GnRH signaling pathway_Homo sapiens_hsa049121.28179115
30Thyroid cancer_Homo sapiens_hsa052161.26765861
31Hedgehog signaling pathway_Homo sapiens_hsa043401.26377701
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25954443
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.24254005
34Peroxisome_Homo sapiens_hsa041461.22953686
35Insulin secretion_Homo sapiens_hsa049111.22532918
36Dorso-ventral axis formation_Homo sapiens_hsa043201.21466458
37Estrogen signaling pathway_Homo sapiens_hsa049151.18074551
38Bladder cancer_Homo sapiens_hsa052191.17316275
39Glycerolipid metabolism_Homo sapiens_hsa005611.14874637
40Vibrio cholerae infection_Homo sapiens_hsa051101.12780266
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12536284
42Glioma_Homo sapiens_hsa052141.11555236
43Renin secretion_Homo sapiens_hsa049241.10339587
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09440103
45Acute myeloid leukemia_Homo sapiens_hsa052211.09207628
46Long-term potentiation_Homo sapiens_hsa047201.08939601
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08684756
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05574709
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.05393196
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04797082
51Malaria_Homo sapiens_hsa051441.01653932
52Proteoglycans in cancer_Homo sapiens_hsa052051.00972481
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00946207
54Tight junction_Homo sapiens_hsa045300.99958745
55Tyrosine metabolism_Homo sapiens_hsa003500.97821516
56Mineral absorption_Homo sapiens_hsa049780.94293806
57Hippo signaling pathway_Homo sapiens_hsa043900.94098844
58Ribosome_Homo sapiens_hsa030100.94085141
59Gastric acid secretion_Homo sapiens_hsa049710.93639831
60PPAR signaling pathway_Homo sapiens_hsa033200.91507170
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90782910
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87126135
63Long-term depression_Homo sapiens_hsa047300.87047092
64Wnt signaling pathway_Homo sapiens_hsa043100.85349924
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.83637389
66Caffeine metabolism_Homo sapiens_hsa002320.81194633
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.81109428
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79303954
69Endometrial cancer_Homo sapiens_hsa052130.78756837
70Chemical carcinogenesis_Homo sapiens_hsa052040.78395171
71Insulin resistance_Homo sapiens_hsa049310.78009483
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77678427
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76010187
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.74904465
75Steroid biosynthesis_Homo sapiens_hsa001000.74691668
76Adherens junction_Homo sapiens_hsa045200.74097753
77Collecting duct acid secretion_Homo sapiens_hsa049660.73974747
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72447713
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72107846
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71660574
81Pertussis_Homo sapiens_hsa051330.70261702
82Glucagon signaling pathway_Homo sapiens_hsa049220.68831866
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68236951
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68057710
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.67346378
86beta-Alanine metabolism_Homo sapiens_hsa004100.66090239
87ECM-receptor interaction_Homo sapiens_hsa045120.66000169
88Ras signaling pathway_Homo sapiens_hsa040140.65425058
89Non-small cell lung cancer_Homo sapiens_hsa052230.65195839
90Measles_Homo sapiens_hsa051620.64742596
91Nitrogen metabolism_Homo sapiens_hsa009100.64550505
92Prion diseases_Homo sapiens_hsa050200.62704118
93Amoebiasis_Homo sapiens_hsa051460.62534128
94Circadian entrainment_Homo sapiens_hsa047130.62445432
95Phototransduction_Homo sapiens_hsa047440.61831718
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61001466
97Graft-versus-host disease_Homo sapiens_hsa053320.60827869
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59928099
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59440180
100Regulation of autophagy_Homo sapiens_hsa041400.59398284
101Amphetamine addiction_Homo sapiens_hsa050310.59293355
102Salivary secretion_Homo sapiens_hsa049700.58694278
103Gap junction_Homo sapiens_hsa045400.58521639
104Oxytocin signaling pathway_Homo sapiens_hsa049210.57471019
105Butanoate metabolism_Homo sapiens_hsa006500.56972198
106Insulin signaling pathway_Homo sapiens_hsa049100.56522878
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.55446502
108Shigellosis_Homo sapiens_hsa051310.53627472
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53367401
110Fatty acid degradation_Homo sapiens_hsa000710.53144268
111Staphylococcus aureus infection_Homo sapiens_hsa051500.52127985
112Olfactory transduction_Homo sapiens_hsa047400.52067217
113Dopaminergic synapse_Homo sapiens_hsa047280.52012134
114Allograft rejection_Homo sapiens_hsa053300.51670006
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51182710
116Autoimmune thyroid disease_Homo sapiens_hsa053200.50109738
117Tryptophan metabolism_Homo sapiens_hsa003800.50047846
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49679201
119Prolactin signaling pathway_Homo sapiens_hsa049170.48942733
120Fatty acid metabolism_Homo sapiens_hsa012120.48915077
121Dilated cardiomyopathy_Homo sapiens_hsa054140.48421984
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.46047542
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45938307
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45620424
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45111199
126Protein digestion and absorption_Homo sapiens_hsa049740.44674076
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44004848
128Protein export_Homo sapiens_hsa030600.43231834
129Tuberculosis_Homo sapiens_hsa051520.42803894
130Ovarian steroidogenesis_Homo sapiens_hsa049130.42088792
131Sphingolipid metabolism_Homo sapiens_hsa006000.41708479
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41098204
133cAMP signaling pathway_Homo sapiens_hsa040240.40559077
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.40508395
135Sulfur metabolism_Homo sapiens_hsa009200.40152126
136Bile secretion_Homo sapiens_hsa049760.39866186
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39837509
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39793435
139MicroRNAs in cancer_Homo sapiens_hsa052060.39783296
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.38901470
141Hepatitis C_Homo sapiens_hsa051600.38692754
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37709307
143Huntingtons disease_Homo sapiens_hsa050160.37393148
144Platelet activation_Homo sapiens_hsa046110.37381115
145Lysosome_Homo sapiens_hsa041420.37281877
146ErbB signaling pathway_Homo sapiens_hsa040120.36879373
147Thyroid hormone synthesis_Homo sapiens_hsa049180.36510392
148Rheumatoid arthritis_Homo sapiens_hsa053230.34735897
149Rap1 signaling pathway_Homo sapiens_hsa040150.34679923
150Osteoclast differentiation_Homo sapiens_hsa043800.34448862
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34277472
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33586473
153Folate biosynthesis_Homo sapiens_hsa007900.31434431
154Salmonella infection_Homo sapiens_hsa051320.29138769
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.28932546
156Apoptosis_Homo sapiens_hsa042100.28806565
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27164863
158Legionellosis_Homo sapiens_hsa051340.27091496
159Calcium signaling pathway_Homo sapiens_hsa040200.26549922
160Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23398958
161TNF signaling pathway_Homo sapiens_hsa046680.22076276

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