ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.54734620
2	adhesion of symbiont to host cell (GO:0044650)	9.54734620
3	citrulline biosynthetic process (GO:0019240)	8.47566977
4	peptide cross-linking (GO:0018149)	8.06989362
5	adhesion of symbiont to host (GO:0044406)	8.00282157
6	hair follicle morphogenesis (GO:0031069)	7.88524204
7	cell wall macromolecule catabolic process (GO:0016998)	6.65471166
8	cell wall macromolecule metabolic process (GO:0044036)	6.65471166
9	establishment of skin barrier (GO:0061436)	6.42993846
10	intermediate filament cytoskeleton organization (GO:0045104)	6.35502175
11	intermediate filament-based process (GO:0045103)	6.16177397
12	epidermis development (GO:0008544)	5.97692969
13	regulation of water loss via skin (GO:0033561)	5.74169737
14	keratinocyte differentiation (GO:0030216)	5.65595089
15	citrulline metabolic process (GO:0000052)	5.36543079
16	skin morphogenesis (GO:0043589)	5.27770528
17	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.15315964
18	molting cycle process (GO:0022404)	5.06794484
19	hair cycle process (GO:0022405)	5.06794484
20	peptidyl-arginine modification (GO:0018195)	4.73588854
21	hemidesmosome assembly (GO:0031581)	4.58957574
22	epidermal cell differentiation (GO:0009913)	4.46725676
23	multicellular organismal water homeostasis (GO:0050891)	4.45302414
24	tooth mineralization (GO:0034505)	4.42280657
25	keratinocyte development (GO:0003334)	4.14195885
26	molting cycle (GO:0042303)	33.3168911
27	hair cycle (GO:0042633)	33.3168911
28	water homeostasis (GO:0030104)	3.61930648
29	negative regulation of keratinocyte proliferation (GO:0010839)	3.48843839
30	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.21602850
31	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.19938047
32	positive regulation of hair follicle development (GO:0051798)	3.15705252
33	positive regulation of hair cycle (GO:0042635)	3.15705252
34	regulation of keratinocyte differentiation (GO:0045616)	3.12208306
35	atrioventricular valve morphogenesis (GO:0003181)	3.08587688
36	hair follicle development (GO:0001942)	3.00128478
37	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.92795147
38	bone trabecula formation (GO:0060346)	2.87972558
39	epithelium development (GO:0060429)	2.87619278
40	regulation of hair follicle development (GO:0051797)	2.86375787
41	positive regulation of meiotic cell cycle (GO:0051446)	2.83583214
42	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.82218952
43	fatty acid elongation (GO:0030497)	2.79876430
44	primary alcohol catabolic process (GO:0034310)	2.79803046
45	ectoderm development (GO:0007398)	2.68454954
46	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.64847550
47	regulation of cardioblast proliferation (GO:0003264)	2.64847550
48	positive regulation of epidermis development (GO:0045684)	2.60325399
49	gap junction assembly (GO:0016264)	2.59432330
50	negative regulation of protein localization to plasma membrane (GO:1903077)	2.58907925
51	regulation of hair cycle (GO:0042634)	2.56809773
52	outflow tract septum morphogenesis (GO:0003148)	2.45435127
53	regulation of epidermal cell differentiation (GO:0045604)	2.43564654
54	ventricular cardiac muscle cell action potential (GO:0086005)	2.34729058
55	regulation of epidermis development (GO:0045682)	2.29536960
56	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.26930144
57	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.26804266
58	lymph vessel development (GO:0001945)	2.25292714
59	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.21885810
60	negative regulation of cell fate specification (GO:0009996)	2.20227305
61	phosphatidylserine metabolic process (GO:0006658)	2.16599089
62	myotube differentiation (GO:0014902)	2.14770248
63	positive regulation of monocyte chemotaxis (GO:0090026)	2.14534328
64	positive regulation of epidermal cell differentiation (GO:0045606)	2.12880343
65	epithelial cell-cell adhesion (GO:0090136)	2.11003499
66	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.10916691
67	skin development (GO:0043588)	2.10672852
68	wound healing, spreading of epidermal cells (GO:0035313)	2.09902511
69	cardiac right ventricle morphogenesis (GO:0003215)	2.08419623
70	ethanol metabolic process (GO:0006067)	2.06814487
71	regulation of ruffle assembly (GO:1900027)	2.06666403
72	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.05844004
73	regulation of cardioblast differentiation (GO:0051890)	2.03000691
74	regulation of keratinocyte proliferation (GO:0010837)	2.00528120
75	regulation of heart rate by cardiac conduction (GO:0086091)	2.00325619
76	intermediate filament organization (GO:0045109)	11.4868700
77	keratinization (GO:0031424)	11.4516752
78	desmosome organization (GO:0002934)	10.1361433
79	cranial suture morphogenesis (GO:0060363)	1.95616029
80	coronary vasculature morphogenesis (GO:0060977)	1.92755381
81	outer ear morphogenesis (GO:0042473)	1.91152757
82	aging (GO:0007568)	1.88251829
83	non-canonical Wnt signaling pathway (GO:0035567)	1.87680193
84	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.86948658
85	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.84934111
86	cell communication involved in cardiac conduction (GO:0086065)	1.84813695
87	negative regulation of epidermis development (GO:0045683)	1.84535007
88	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.82500027
89	long-chain fatty acid biosynthetic process (GO:0042759)	1.73991772
90	cellular zinc ion homeostasis (GO:0006882)	1.73212728
91	negative regulation of Ras GTPase activity (GO:0034261)	1.70046157
92	pharyngeal system development (GO:0060037)	1.69612259
93	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.68334767
94	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.67793222
95	wound healing, spreading of cells (GO:0044319)	1.67388593
96	ephrin receptor signaling pathway (GO:0048013)	1.61110532
97	cardiac conduction (GO:0061337)	1.59592177
98	regulation of cell fate specification (GO:0042659)	1.56784375
99	COPI coating of Golgi vesicle (GO:0048205)	1.56327699
100	Golgi transport vesicle coating (GO:0048200)	1.56327699

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	8.34046929
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.54659298
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.43755166
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.48638969
5	* CTCF_20526341_ChIP-Seq_ESCs_Human	2.13202480
6	* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.07954684
7	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.04679351
8	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.02586232
9	TP63_17297297_ChIP-ChIP_HaCaT_Human	11.5342948
10	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.76024573
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.75675057
12	ERG_20517297_ChIP-Seq_VCAP_Human	1.75606575
13	E2F1_20622854_ChIP-Seq_HELA_Human	1.68288992
14	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.65466991
15	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.65069899
16	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.64368858
17	CTCF_27219007_Chip-Seq_Bcells_Human	1.63584924
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.59635656
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.59439977
20	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.56778132
21	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.56604588
22	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.55620947
23	EGR1_19032775_ChIP-ChIP_M12_Human	1.55174850
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54363810
25	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.45261077
26	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43346022
27	* TP63_22573176_ChIP-Seq_HFKS_Human	1.41945481
28	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41542481
29	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.41257830
30	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.40363460
31	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.39241005
32	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.39241005
33	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.38510424
34	LXR_22292898_ChIP-Seq_THP-1_Human	1.36978410
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.34154492
36	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33963834
37	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.31360730
38	RACK7_27058665_Chip-Seq_MCF-7_Human	1.30673532
39	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.28066848
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27830620
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.27830142
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21763015
43	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.21407397
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21390898
45	BCOR_27268052_Chip-Seq_Bcells_Human	1.20557083
46	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.19786023
47	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.18911418
48	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.18540060
49	* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.18438081
50	ATF3_27146783_Chip-Seq_COLON_Human	1.18323148
51	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18322717
52	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.15659739
53	PHF8_20622854_ChIP-Seq_HELA_Human	1.14634371
54	* TP63_23658742_ChIP-Seq_EP156T_Human	1.14467781
55	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13161058
56	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.11764161
57	CEBPB_22108803_ChIP-Seq_LS180_Human	1.10925317
58	P68_20966046_ChIP-Seq_HELA_Human	1.07140519
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.07032157
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.06797075
61	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06660520
62	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06573317
63	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.05955718
64	SOX2_20726797_ChIP-Seq_SW620_Human	1.04063382
65	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.03169195
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.02160790
67	SOX2_21211035_ChIP-Seq_LN229_Human	1.01844931
68	SMC4_20622854_ChIP-Seq_HELA_Human	1.01064994
69	RAC3_21632823_ChIP-Seq_H3396_Human	1.00002476
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99307169
71	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98422125
72	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.98062755
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97707842
74	RXR_22108803_ChIP-Seq_LS180_Human	0.96082721
75	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95847595
76	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.95732868
77	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95225501
78	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.95140645
79	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.94923007
80	AR_21572438_ChIP-Seq_LNCaP_Human	0.94122076
81	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.93936243
82	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.93588548
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.92519113
84	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92388219
85	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.87146311
86	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.86818473
87	KLF5_25053715_ChIP-Seq_YYC3_Human	0.86404494
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.84296661
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.84062378
90	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.83851079
91	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.83353799
92	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.82129768
93	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.81849325
94	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.81553412
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.81446141
96	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.81256196
97	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.80805759
98	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.80805759
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80413391
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80413391

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.52987919
2	MP0002098_abnormal_vibrissa_morphology	7.11065922
3	MP0000647_abnormal_sebaceous_gland	6.45366969
4	MP0002796_impaired_skin_barrier	6.05981927
5	MP0005275_abnormal_skin_tensile	5.26466338
6	MP0010234_abnormal_vibrissa_follicle	5.15550709
7	MP0000383_abnormal_hair_follicle	4.44755472
8	MP0010678_abnormal_skin_adnexa	3.97490653
9	MP0000377_abnormal_hair_follicle	3.95196868
10	MP0005501_abnormal_skin_physiology	3.71981643
11	MP0000427_abnormal_hair_cycle	3.62165050
12	MP0003705_abnormal_hypodermis_morpholog	3.30299826
13	MP0002254_reproductive_system_inflammat	3.02336822
14	MP0001216_abnormal_epidermal_layer	2.64844214
15	MP0010771_integument_phenotype	2.38573445
16	MP0000367_abnormal_coat/_hair	2.32939632
17	MP0004381_abnormal_hair_follicle	2.24491090
18	MP0002234_abnormal_pharynx_morphology	2.24253430
19	MP0002060_abnormal_skin_morphology	2.23584021
20	MP0001243_abnormal_dermal_layer	2.20439881
21	MP0004947_skin_inflammation	2.19151018
22	MP0003453_abnormal_keratinocyte_physiol	2.02265073
23	MP0000467_abnormal_esophagus_morphology	1.57546617
24	MP0000762_abnormal_tongue_morphology	1.53444936
25	MP0005409_darkened_coat_color	1.52569449
26	MP0009931_abnormal_skin_appearance	1.44958269
27	MP0009053_abnormal_anal_canal	1.37830774
28	MP0004264_abnormal_extraembryonic_tissu	1.30152697
29	MP0003566_abnormal_cell_adhesion	1.18864469
30	MP0003941_abnormal_skin_development	1.09207389
31	MP0001191_abnormal_skin_condition	1.00582668
32	MP0004885_abnormal_endolymph	0.93019653
33	MP0002877_abnormal_melanocyte_morpholog	0.88821911
34	MP0000013_abnormal_adipose_tissue	0.88667696
35	MP0002095_abnormal_skin_pigmentation	0.82923434
36	MP0001851_eye_inflammation	0.74818036
37	MP0001340_abnormal_eyelid_morphology	0.74730264
38	MP0000678_abnormal_parathyroid_gland	0.74658418
39	MP0001346_abnormal_lacrimal_gland	0.70786816
40	MP0004185_abnormal_adipocyte_glucose	0.70122325
41	MP0005645_abnormal_hypothalamus_physiol	0.62423432
42	MP0004019_abnormal_vitamin_homeostasis	0.61587008
43	MP0010030_abnormal_orbit_morphology	0.58396401
44	MP0003315_abnormal_perineum_morphology	0.56909421
45	MP0002970_abnormal_white_adipose	0.54192387
46	MP0001188_hyperpigmentation	0.53399964
47	MP0002282_abnormal_trachea_morphology	0.53087296
48	MP0000566_synostosis	0.48507430
49	MP0008438_abnormal_cutaneous_collagen	0.48242494
50	MP0003755_abnormal_palate_morphology	0.48169436
51	MP0001784_abnormal_fluid_regulation	0.46665604
52	MP0002909_abnormal_adrenal_gland	0.45495543
53	MP0000627_abnormal_mammary_gland	0.45072900
54	MP0001849_ear_inflammation	0.44226437
55	MP0002177_abnormal_outer_ear	0.42978795
56	MP0003191_abnormal_cellular_cholesterol	0.41373082
57	MP0006054_spinal_hemorrhage	0.41337085
58	MP0003122_maternal_imprinting	0.41227464
59	MP0004272_abnormal_basement_membrane	0.40953287
60	MP0002111_abnormal_tail_morphology	0.40763869
61	MP0001661_extended_life_span	0.39745578
62	MP0009379_abnormal_foot_pigmentation	0.36939884
63	MP0000003_abnormal_adipose_tissue	0.36443682
64	MP0000537_abnormal_urethra_morphology	0.33867621
65	MP0005023_abnormal_wound_healing	0.33782650
66	MP0005451_abnormal_body_composition	0.31252234
67	MP0008961_abnormal_basal_metabolism	0.31232699
68	MP0002249_abnormal_larynx_morphology	0.29619093
69	MP0005075_abnormal_melanosome_morpholog	0.25758337
70	MP0003385_abnormal_body_wall	0.24688707
71	MP0003123_paternal_imprinting	0.23706891
72	MP0000538_abnormal_urinary_bladder	0.23534935
73	MP0005375_adipose_tissue_phenotype	0.23141052
74	MP0002697_abnormal_eye_size	0.21902353
75	MP0004742_abnormal_vestibular_system	0.21621709
76	MP0003195_calcinosis	0.20393007
77	MP0003329_amyloid_beta_deposits	0.20330099
78	MP0002896_abnormal_bone_mineralization	0.19643553
79	MP0005452_abnormal_adipose_tissue	0.19283331
80	MP0003183_abnormal_peptide_metabolism	0.17541770
81	MP0003935_abnormal_craniofacial_develop	0.17534038
82	MP0000432_abnormal_head_morphology	0.16825279
83	MP0000751_myopathy	0.15788887
84	MP0000516_abnormal_urinary_system	0.15595976
85	MP0005367_renal/urinary_system_phenotyp	0.15595976
86	MP0003638_abnormal_response/metabolism_	0.14611631
87	MP0000462_abnormal_digestive_system	0.11867236
88	MP0001879_abnormal_lymphatic_vessel	0.11565424
89	MP0009840_abnormal_foam_cell	0.10866581
90	MP0002233_abnormal_nose_morphology	0.10630990
91	MP0004782_abnormal_surfactant_physiolog	0.10605431
92	MP0000465_gastrointestinal_hemorrhage	0.10363160
93	MP0002733_abnormal_thermal_nociception	0.09518025
94	MP0010368_abnormal_lymphatic_system	0.09238308
95	MP0001765_abnormal_ion_homeostasis	0.09220042
96	MP0003300_gastrointestinal_ulcer	0.09159879
97	MP0005508_abnormal_skeleton_morphology	0.08897591
98	MP0000613_abnormal_salivary_gland	0.07302702
99	MP0005257_abnormal_intraocular_pressure	0.06302131
100	MP0008569_lethality_at_weaning	0.06275748

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.29298358
2	Nail dystrophy (HP:0008404)	7.03686944
3	Abnormal hair laboratory examination (HP:0003328)	5.86559385
4	Abnormality of nail color (HP:0100643)	5.86301928
5	Fragile nails (HP:0001808)	5.65600468
6	Onycholysis (HP:0001806)	5.20397108
7	Fine hair (HP:0002213)	5.03220899
8	Increased IgE level (HP:0003212)	4.81252912
9	Palmoplantar hyperkeratosis (HP:0000972)	4.74637823
10	Alopecia of scalp (HP:0002293)	4.58220580
11	Palmar hyperkeratosis (HP:0010765)	4.43589509
12	Plantar hyperkeratosis (HP:0007556)	4.36219558
13	Right ventricular cardiomyopathy (HP:0011663)	4.19904923
14	Follicular hyperkeratosis (HP:0007502)	4.15276762
15	Thick nail (HP:0001805)	3.93451091
16	Erythema (HP:0010783)	3.53373362
17	Amelogenesis imperfecta (HP:0000705)	3.36500346
18	Sparse eyelashes (HP:0000653)	3.35973008
19	Abnormality of the frontal sinuses (HP:0002687)	3.30372020
20	Milia (HP:0001056)	3.15537637
21	Erythroderma (HP:0001019)	3.06813505
22	Curly hair (HP:0002212)	3.02761339
23	Oral leukoplakia (HP:0002745)	2.84807274
24	Congenital ichthyosiform erythroderma (HP:0007431)	2.66686214
25	Parakeratosis (HP:0001036)	2.65264442
26	Congenital, generalized hypertrichosis (HP:0004540)	2.61150076
27	Ridged nail (HP:0001807)	2.54503111
28	Intention tremor (HP:0002080)	2.49295931
29	Aplasia cutis congenita (HP:0001057)	2.43844778
30	Dry hair (HP:0011359)	2.39562799
31	Neck muscle weakness (HP:0000467)	2.34938275
32	Torticollis (HP:0000473)	2.31935232
33	Abnormal blistering of the skin (HP:0008066)	2.30446660
34	Advanced eruption of teeth (HP:0006288)	2.26637623
35	Natal tooth (HP:0000695)	2.23843207
36	Corneal erosion (HP:0200020)	2.20831841
37	Hypohidrosis (HP:0000966)	2.18558920
38	Abnormality of dental color (HP:0011073)	2.09355611
39	Hypotrichosis (HP:0001006)	14.5879766
40	Woolly hair (HP:0002224)	11.1582686
41	Slow-growing hair (HP:0002217)	10.8043678
42	Abnormality of hair growth rate (HP:0011363)	10.8043678
43	Brittle hair (HP:0002299)	10.0842569
44	Palmoplantar keratoderma (HP:0000982)	1.98730485
45	Craniofacial dystonia (HP:0012179)	1.95835223
46	Abnormality of the dental root (HP:0006486)	1.93382700
47	Taurodontia (HP:0000679)	1.93382700
48	Abnormality of permanent molar morphology (HP:0011071)	1.93382700
49	Conjunctival hamartoma (HP:0100780)	1.90406629
50	Abnormality of molar (HP:0011077)	1.88580100
51	Abnormality of molar morphology (HP:0011070)	1.88580100
52	Distal lower limb muscle weakness (HP:0009053)	1.88376917
53	Pruritus (HP:0000989)	1.86926635
54	Ventricular tachycardia (HP:0004756)	1.85438530
55	Concave nail (HP:0001598)	1.85073057
56	Abnormality of the pupil (HP:0000615)	1.84533866
57	Difficulty walking (HP:0002355)	1.83818438
58	Focal dystonia (HP:0004373)	1.83778733
59	Absent eyelashes (HP:0000561)	1.79587599
60	Abnormality of the dental pulp (HP:0006479)	1.78144867
61	Unilateral renal agenesis (HP:0000122)	1.75602237
62	Widely patent fontanelles and sutures (HP:0004492)	1.72948480
63	Abnormality of the parietal bone (HP:0002696)	1.71291858
64	Ventricular fibrillation (HP:0001663)	1.67983763
65	Lip pit (HP:0100267)	1.65473882
66	Craniofacial hyperostosis (HP:0004493)	1.49932051
67	Sudden death (HP:0001699)	1.49645609
68	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.48074394
69	Acanthosis nigricans (HP:0000956)	1.47978563
70	Heterogeneous (HP:0001425)	1.47366158
71	Abnormality of the aortic arch (HP:0012303)	1.46941483
72	Recurrent corneal erosions (HP:0000495)	1.46863229
73	Fatigable weakness (HP:0003473)	1.45234027
74	Abnormality of the neuromuscular junction (HP:0003398)	1.45234027
75	Widely spaced teeth (HP:0000687)	1.43701343
76	Hyporeflexia of lower limbs (HP:0002600)	1.42904480
77	Blepharitis (HP:0000498)	1.42868705
78	Carious teeth (HP:0000670)	1.41946958
79	Hypergammaglobulinemia (HP:0010702)	1.41784474
80	Round ear (HP:0100830)	1.41171488
81	Type 1 muscle fiber predominance (HP:0003803)	1.39253502
82	Hyperthyroidism (HP:0000836)	1.38220339
83	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.34927875
84	Gangrene (HP:0100758)	1.33713951
85	Abnormality of placental membranes (HP:0011409)	1.32996602
86	Amniotic constriction ring (HP:0009775)	1.32996602
87	Atrophic scars (HP:0001075)	1.32961375
88	Ulnar deviation of the wrist (HP:0003049)	1.29594264
89	Autoamputation (HP:0001218)	1.26240099
90	Keratoconjunctivitis sicca (HP:0001097)	1.23144567
91	Sparse scalp hair (HP:0002209)	1.20458082
92	Abnormality of the fingernails (HP:0001231)	1.20176672
93	Ectropion (HP:0000656)	1.19506547
94	Anonychia (HP:0001798)	1.17779269
95	Bronchomalacia (HP:0002780)	1.16055203
96	Variable expressivity (HP:0003828)	1.15699324
97	Hamartoma of the eye (HP:0010568)	1.14832733
98	Cranial hyperostosis (HP:0004437)	1.13336145
99	Neonatal onset (HP:0003623)	1.12288790
100	Congenital malformation of the right heart (HP:0011723)	1.12183632

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.25124636
2	FER	4.19703623
3	MAPKAPK3	3.95969156
4	PIK3CG	3.68962323
5	ERN1	3.26660431
6	MAP3K6	2.94618842
7	TAOK1	2.88438161
8	MAP3K3	2.76462967
9	EPHB2	2.74301046
10	MAP3K2	2.52324429
11	AKT3	2.25646064
12	MAPK15	2.20852657
13	SIK1	2.10301599
14	MAP3K11	1.93760222
15	RPS6KB2	1.91375133
16	LATS1	1.88808676
17	MAP2K6	1.79710797
18	SIK3	1.71765801
19	NME1	1.71398859
20	MAP3K1	1.50206821
21	MST4	1.49824745
22	TTN	1.49564342
23	KSR2	1.48085840
24	MAP2K3	1.46365124
25	WNK3	1.41013604
26	TRIB3	1.34100617
27	PAK3	1.33271105
28	MAP2K4	1.28229398
29	LATS2	1.24896556
30	FGFR2	1.13318121
31	MAP3K9	1.12357995
32	BCR	1.10192779
33	EPHB1	1.06354746
34	OBSCN	1.04370127
35	RIPK1	1.03652225
36	SIK2	1.00369194
37	PBK	0.98733806
38	TYRO3	0.94322219
39	WNK4	0.93650657
40	MAPKAPK2	0.93266306
41	DYRK1B	0.91534754
42	MAP2K2	0.88638488
43	FGFR1	0.88122745
44	MST1R	0.87052719
45	ERBB3	0.86292435
46	CDK6	0.85842691
47	TNK2	0.83165549
48	PTK2	0.81440826
49	MAP2K1	0.80577836
50	NTRK3	0.80188767
51	STK38L	0.76505792
52	EEF2K	0.75946250
53	FGFR4	0.75590722
54	BMX	0.75181605
55	LRRK2	0.73840460
56	PTK6	0.69419252
57	MAP3K7	0.68844478
58	PRKCI	0.68047706
59	SGK3	0.67038052
60	FGFR3	0.66867750
61	HIPK2	0.63501720
62	PAK6	0.63209396
63	PRKD1	0.60983260
64	TESK1	0.60521175
65	GRK7	0.59566350
66	PRKCH	0.56557209
67	RPS6KA4	0.56229439
68	STK38	0.55608755
69	CDC42BPA	0.53383439
70	MARK3	0.52364923
71	ADRBK2	0.51295374
72	CAMKK2	0.49832117
73	MAP3K5	0.49169323
74	UHMK1	0.48489389
75	ADRBK1	0.47811537
76	PDGFRA	0.47073465
77	NTRK2	0.46151631
78	STK24	0.43180842
79	RET	0.42829409
80	MARK2	0.42360068
81	GSK3A	0.40947278
82	CDK19	0.40568931
83	RPS6KA1	0.34980755
84	EPHA3	0.33954214
85	PRKACA	0.33252951
86	PASK	0.32337873
87	NTRK1	0.32037644
88	FRK	0.31622654
89	CSNK1E	0.30776031
90	DDR2	0.29935248
91	PKN2	0.29213864
92	TGFBR1	0.28311856
93	PAK2	0.27696914
94	MAPKAPK5	0.27411231
95	CSNK1A1	0.26858730
96	SGK1	0.26812624
97	PRKCA	0.24286518
98	PRKACG	0.22973612
99	PHKG1	0.22527072
100	PHKG2	0.22527072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	4.21234590
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.20329518
3	Fatty acid elongation_Homo sapiens_hsa00062	2.95937813
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.50505279
5	Phenylalanine metabolism_Homo sapiens_hsa00360	2.44334281
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.12759177
7	Tyrosine metabolism_Homo sapiens_hsa00350	1.95786042
8	Basal cell carcinoma_Homo sapiens_hsa05217	1.89395392
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.70057160
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67482742
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.62922849
12	Melanogenesis_Homo sapiens_hsa04916	1.62076333
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.61499480
14	Histidine metabolism_Homo sapiens_hsa00340	1.59958738
15	Vibrio cholerae infection_Homo sapiens_hsa05110	1.44666150
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.44359128
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.37031744
18	Axon guidance_Homo sapiens_hsa04360	1.31181886
19	VEGF signaling pathway_Homo sapiens_hsa04370	1.23930291
20	Bladder cancer_Homo sapiens_hsa05219	1.18207508
21	Pancreatic secretion_Homo sapiens_hsa04972	1.17221618
22	Thyroid cancer_Homo sapiens_hsa05216	1.16150906
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.15889588
24	Long-term depression_Homo sapiens_hsa04730	1.13624558
25	Long-term potentiation_Homo sapiens_hsa04720	1.12527180
26	Estrogen signaling pathway_Homo sapiens_hsa04915	1.11611099
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09282405
28	Tight junction_Homo sapiens_hsa04530	1.09231051
29	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.07090669
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.06697113
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.05753598
32	Renin secretion_Homo sapiens_hsa04924	1.05590800
33	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.04399060
34	Glioma_Homo sapiens_hsa05214	1.03569569
35	Protein export_Homo sapiens_hsa03060	1.02698390
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.02249632
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.01147484
38	Hippo signaling pathway_Homo sapiens_hsa04390	0.99194597
39	Mineral absorption_Homo sapiens_hsa04978	0.92034895
40	Gastric acid secretion_Homo sapiens_hsa04971	0.91543933
41	Sulfur metabolism_Homo sapiens_hsa00920	0.90173095
42	Insulin secretion_Homo sapiens_hsa04911	0.90082391
43	Proteoglycans in cancer_Homo sapiens_hsa05205	0.89876351
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89475306
45	Acute myeloid leukemia_Homo sapiens_hsa05221	0.88236070
46	Fatty acid degradation_Homo sapiens_hsa00071	0.85928413
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85125250
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84930313
49	ECM-receptor interaction_Homo sapiens_hsa04512	0.84202739
50	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83397419
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.82076039
52	Amphetamine addiction_Homo sapiens_hsa05031	0.81372768
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.80184908
54	Adherens junction_Homo sapiens_hsa04520	0.77801292
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76067484
56	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74209837
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.71457921
58	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70907245
59	Pertussis_Homo sapiens_hsa05133	0.70723078
60	Serotonergic synapse_Homo sapiens_hsa04726	0.70257251
61	Circadian entrainment_Homo sapiens_hsa04713	0.69505653
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.69370441
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.68587345
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.67629476
65	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64690472
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64478724
67	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.64288195
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.63823261
69	Prion diseases_Homo sapiens_hsa05020	0.63356969
70	Ras signaling pathway_Homo sapiens_hsa04014	0.62377441
71	Phototransduction_Homo sapiens_hsa04744	0.62366886
72	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.59933233
73	Amoebiasis_Homo sapiens_hsa05146	0.59524952
74	Protein digestion and absorption_Homo sapiens_hsa04974	0.58621741
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58193308
76	Gap junction_Homo sapiens_hsa04540	0.55604065
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.55367500
78	Endometrial cancer_Homo sapiens_hsa05213	0.54876855
79	Caffeine metabolism_Homo sapiens_hsa00232	0.54420649
80	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.53241141
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.52750848
82	Salivary secretion_Homo sapiens_hsa04970	0.52655746
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52599925
84	Insulin resistance_Homo sapiens_hsa04931	0.51679207
85	Butanoate metabolism_Homo sapiens_hsa00650	0.50830482
86	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48523618
87	Non-small cell lung cancer_Homo sapiens_hsa05223	0.47928149
88	Insulin signaling pathway_Homo sapiens_hsa04910	0.46706555
89	Alzheimers disease_Homo sapiens_hsa05010	0.45489550
90	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45087823
91	GABAergic synapse_Homo sapiens_hsa04727	0.44740031
92	Cocaine addiction_Homo sapiens_hsa05030	0.42761051
93	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.42410442
94	Olfactory transduction_Homo sapiens_hsa04740	0.42049772
95	Lysosome_Homo sapiens_hsa04142	0.38198347
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38177980
97	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36789182
98	ErbB signaling pathway_Homo sapiens_hsa04012	0.35540613
99	Rap1 signaling pathway_Homo sapiens_hsa04015	0.35037557
100	Cardiac muscle contraction_Homo sapiens_hsa04260	0.34413710

KRTAP17-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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