ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.61371225
2	adhesion of symbiont to host cell (GO:0044650)	9.61371225
3	citrulline biosynthetic process (GO:0019240)	8.64203003
4	peptide cross-linking (GO:0018149)	8.62959745
5	hair follicle morphogenesis (GO:0031069)	8.34615959
6	adhesion of symbiont to host (GO:0044406)	8.09763088
7	intermediate filament cytoskeleton organization (GO:0045104)	6.84259276
8	intermediate filament-based process (GO:0045103)	6.62298307
9	epidermis development (GO:0008544)	6.33146062
10	establishment of skin barrier (GO:0061436)	6.11914764
11	keratinocyte differentiation (GO:0030216)	5.82410334
12	cell wall macromolecule catabolic process (GO:0016998)	5.78574560
13	cell wall macromolecule metabolic process (GO:0044036)	5.78574560
14	citrulline metabolic process (GO:0000052)	5.72236145
15	regulation of water loss via skin (GO:0033561)	5.42425725
16	molting cycle process (GO:0022404)	5.35107676
17	hair cycle process (GO:0022405)	5.35107676
18	hemidesmosome assembly (GO:0031581)	5.01264240
19	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.93353654
20	peptidyl-arginine modification (GO:0018195)	4.75594099
21	skin morphogenesis (GO:0043589)	4.53876962
22	epidermal cell differentiation (GO:0009913)	4.52906167
23	hair cycle (GO:0042633)	34.6233189
24	molting cycle (GO:0042303)	34.6233189
25	keratinocyte development (GO:0003334)	3.84725718
26	tooth mineralization (GO:0034505)	3.66148150
27	multicellular organismal water homeostasis (GO:0050891)	3.62373839
28	regulation of keratinocyte differentiation (GO:0045616)	3.45531485
29	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.45363177
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.31734908
31	positive regulation of hair follicle development (GO:0051798)	3.18226034
32	positive regulation of hair cycle (GO:0042635)	3.18226034
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.15493065
34	hair follicle development (GO:0001942)	3.15098241
35	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.06186752
36	bone trabecula formation (GO:0060346)	2.99369904
37	epithelium development (GO:0060429)	2.99176445
38	water homeostasis (GO:0030104)	2.97491295
39	regulation of hair follicle development (GO:0051797)	2.94012985
40	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.93205676
41	gap junction assembly (GO:0016264)	2.87762967
42	positive regulation of meiotic cell cycle (GO:0051446)	2.82219527
43	regulation of hair cycle (GO:0042634)	2.70736370
44	positive regulation of epidermis development (GO:0045684)	2.67037039
45	regulation of epidermal cell differentiation (GO:0045604)	2.66406470
46	ectoderm development (GO:0007398)	2.62853884
47	fatty acid elongation (GO:0030497)	2.59762866
48	negative regulation of protein localization to plasma membrane (GO:1903077)	2.53822833
49	regulation of epidermis development (GO:0045682)	2.51752447
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.42716932
51	positive regulation of monocyte chemotaxis (GO:0090026)	2.41179951
52	atrioventricular valve morphogenesis (GO:0003181)	2.40454969
53	phosphatidylserine metabolic process (GO:0006658)	2.37703426
54	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.31228385
55	ventricular cardiac muscle cell action potential (GO:0086005)	2.28340366
56	wound healing, spreading of epidermal cells (GO:0035313)	2.27661684
57	positive regulation of epidermal cell differentiation (GO:0045606)	2.20304617
58	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.19740316
59	cranial suture morphogenesis (GO:0060363)	2.19095429
60	negative regulation of cell fate specification (GO:0009996)	2.13611242
61	regulation of ruffle assembly (GO:1900027)	2.13373670
62	skin development (GO:0043588)	2.12600658
63	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.05087564
64	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.04526921
65	aging (GO:0007568)	2.03980999
66	keratinization (GO:0031424)	12.4366277
67	intermediate filament organization (GO:0045109)	12.2762421
68	desmosome organization (GO:0002934)	10.1090803
69	negative regulation of epidermis development (GO:0045683)	1.96553997
70	epithelial cell-cell adhesion (GO:0090136)	1.92598696
71	regulation of heart rate by cardiac conduction (GO:0086091)	1.90926658
72	ephrin receptor signaling pathway (GO:0048013)	1.90531993
73	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.90097152
74	regulation of cardioblast differentiation (GO:0051890)	1.88968151
75	lymph vessel development (GO:0001945)	1.88120444
76	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.87970967
77	cell communication involved in cardiac conduction (GO:0086065)	1.84999148
78	regulation of keratinocyte proliferation (GO:0010837)	1.84017085
79	outflow tract septum morphogenesis (GO:0003148)	1.81917282
80	myotube differentiation (GO:0014902)	1.81472133
81	cell-substrate junction assembly (GO:0007044)	1.81392612
82	non-canonical Wnt signaling pathway (GO:0035567)	1.76397808
83	alditol phosphate metabolic process (GO:0052646)	1.75315893
84	keratinocyte proliferation (GO:0043616)	1.74669158
85	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.72589540
86	regulation of monocyte chemotaxis (GO:0090025)	1.72096262
87	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.70740737
88	primary alcohol catabolic process (GO:0034310)	1.69631526
89	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.69581182
90	very long-chain fatty acid metabolic process (GO:0000038)	1.67756883
91	response to UV-B (GO:0010224)	1.63153611
92	negative regulation of epidermal cell differentiation (GO:0045605)	1.61082254
93	establishment of tissue polarity (GO:0007164)	1.59592801
94	establishment of planar polarity (GO:0001736)	1.59592801
95	wound healing, spreading of cells (GO:0044319)	1.59471293
96	craniofacial suture morphogenesis (GO:0097094)	1.58760142
97	positive regulation of protein export from nucleus (GO:0046827)	1.56124324
98	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.55154400
99	phosphatidylglycerol metabolic process (GO:0046471)	1.54940477
100	eyelid development in camera-type eye (GO:0061029)	1.54602290

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.78363652
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.06209088
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.63085924
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.68114147
5	* CTCF_20526341_ChIP-Seq_ESCs_Human	2.22606760
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.11645980
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.02801554
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.7377291
9	TAF2_19829295_ChIP-Seq_ESCs_Human	1.86569774
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.85873880
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.84558176
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.77352954
13	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.73889293
14	EGR1_19032775_ChIP-ChIP_M12_Human	1.73323006
15	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.72200900
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.72162767
17	ERG_20517297_ChIP-Seq_VCAP_Human	1.71012689
18	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.66003328
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.65998742
20	CTCF_27219007_Chip-Seq_Bcells_Human	1.61509353
21	BCL6_27268052_Chip-Seq_Bcells_Human	1.55885934
22	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.55299034
23	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.52836670
24	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.52232893
25	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.50929333
26	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.50929333
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.50407919
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.50113740
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.48916995
30	BCOR_27268052_Chip-Seq_Bcells_Human	1.48291949
31	LXR_22292898_ChIP-Seq_THP-1_Human	1.45593109
32	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.40044264
33	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.39878446
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38951725
35	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.38111568
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38091720
37	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36446402
38	ATF3_27146783_Chip-Seq_COLON_Human	1.34524889
39	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33187516
40	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27476455
41	PHF8_20622854_ChIP-Seq_HELA_Human	1.27397000
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27097410
43	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.26897160
44	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.26793010
45	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.25867982
46	P68_20966046_ChIP-Seq_HELA_Human	1.25368404
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.25305677
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20357660
49	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.20150649
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19767478
51	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.19755971
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18364237
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15935213
54	TP63_23658742_ChIP-Seq_EP156T_Human	1.14865491
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.12736424
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.11463488
57	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.09971904
58	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09749545
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08286664
60	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07661763
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06033759
62	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.05949569
63	SOX2_21211035_ChIP-Seq_LN229_Human	1.05930824
64	SMC4_20622854_ChIP-Seq_HELA_Human	1.05469949
65	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04594927
66	SPI1_20517297_ChIP-Seq_HL60_Human	1.03949960
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.03680668
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02987286
69	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.02725173
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02695555
71	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.02433603
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.98871044
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97527504
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96856978
75	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.94438858
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.94065265
77	KLF5_25053715_ChIP-Seq_YYC3_Human	0.93493265
78	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92720244
79	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92039535
80	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91685851
81	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90921135
82	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.90469644
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.89458466
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88400369
85	RXR_22108803_ChIP-Seq_LS180_Human	0.87856664
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.85515012
87	SOX2_20726797_ChIP-Seq_SW620_Human	0.83641981
88	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.83197446
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80758871
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.78982899
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.78597344
92	ZNF263_19887448_ChIP-Seq_K562_Human	0.78556600
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77361646
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.76788087
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.76788087
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.75420447
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.75218193
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.75197813
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.74491119
100	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.74055414

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.49895360
2	MP0002098_abnormal_vibrissa_morphology	7.17895218
3	MP0000647_abnormal_sebaceous_gland	6.35694420
4	MP0002796_impaired_skin_barrier	5.98582162
5	MP0005275_abnormal_skin_tensile	5.15569191
6	MP0010234_abnormal_vibrissa_follicle	5.15401257
7	MP0000383_abnormal_hair_follicle	4.57351876
8	MP0010678_abnormal_skin_adnexa	4.06332762
9	MP0000377_abnormal_hair_follicle	4.02849643
10	MP0005501_abnormal_skin_physiology	3.73384829
11	MP0003705_abnormal_hypodermis_morpholog	3.71831646
12	MP0000427_abnormal_hair_cycle	3.38724000
13	MP0002254_reproductive_system_inflammat	3.19198326
14	MP0001216_abnormal_epidermal_layer	2.69778694
15	MP0004381_abnormal_hair_follicle	2.54117517
16	MP0000367_abnormal_coat/_hair	2.39184554
17	MP0010771_integument_phenotype	2.36160264
18	MP0004947_skin_inflammation	2.29913606
19	MP0002060_abnormal_skin_morphology	2.24525872
20	MP0003453_abnormal_keratinocyte_physiol	2.21278503
21	MP0001243_abnormal_dermal_layer	2.10254156
22	MP0002234_abnormal_pharynx_morphology	1.94588944
23	MP0000467_abnormal_esophagus_morphology	1.79420956
24	MP0009931_abnormal_skin_appearance	1.54143886
25	MP0009053_abnormal_anal_canal	1.53333223
26	MP0000762_abnormal_tongue_morphology	1.50673648
27	MP0003566_abnormal_cell_adhesion	1.47487793
28	MP0003941_abnormal_skin_development	1.32171904
29	MP0005409_darkened_coat_color	1.31476976
30	MP0004885_abnormal_endolymph	1.01932793
31	MP0001191_abnormal_skin_condition	1.01178583
32	MP0004185_abnormal_adipocyte_glucose	0.99514720
33	MP0004264_abnormal_extraembryonic_tissu	0.92160302
34	MP0008438_abnormal_cutaneous_collagen	0.88202016
35	MP0002095_abnormal_skin_pigmentation	0.77841693
36	MP0001851_eye_inflammation	0.74998879
37	MP0003315_abnormal_perineum_morphology	0.70403446
38	MP0002877_abnormal_melanocyte_morpholog	0.65619451
39	MP0001346_abnormal_lacrimal_gland	0.63658682
40	MP0001340_abnormal_eyelid_morphology	0.62366898
41	MP0001849_ear_inflammation	0.61815234
42	MP0003191_abnormal_cellular_cholesterol	0.61785063
43	MP0010030_abnormal_orbit_morphology	0.61773880
44	MP0000566_synostosis	0.60615819
45	MP0000627_abnormal_mammary_gland	0.55481412
46	MP0005451_abnormal_body_composition	0.54821715
47	MP0001661_extended_life_span	0.53038601
48	MP0002282_abnormal_trachea_morphology	0.52773980
49	MP0005023_abnormal_wound_healing	0.49180174
50	MP0003755_abnormal_palate_morphology	0.47401464
51	MP0009379_abnormal_foot_pigmentation	0.47288546
52	MP0002970_abnormal_white_adipose	0.45045169
53	MP0001784_abnormal_fluid_regulation	0.44195250
54	MP0002111_abnormal_tail_morphology	0.40599932
55	MP0010352_gastrointestinal_tract_polyps	0.36276141
56	MP0004272_abnormal_basement_membrane	0.32735834
57	MP0000537_abnormal_urethra_morphology	0.31811336
58	MP0009840_abnormal_foam_cell	0.31694066
59	MP0003385_abnormal_body_wall	0.30976025
60	MP0002177_abnormal_outer_ear	0.30182255
61	MP0003329_amyloid_beta_deposits	0.29658084
62	MP0002249_abnormal_larynx_morphology	0.28593382
63	MP0005075_abnormal_melanosome_morpholog	0.27503152
64	MP0003950_abnormal_plasma_membrane	0.25702726
65	MP0000465_gastrointestinal_hemorrhage	0.24301484
66	MP0003763_abnormal_thymus_physiology	0.24032716
67	MP0002697_abnormal_eye_size	0.22908271
68	MP0005248_abnormal_Harderian_gland	0.20306825
69	MP0006054_spinal_hemorrhage	0.19781542
70	MP0000678_abnormal_parathyroid_gland	0.19238773
71	MP0004019_abnormal_vitamin_homeostasis	0.18426277
72	MP0005666_abnormal_adipose_tissue	0.18327726
73	MP0000604_amyloidosis	0.17793915
74	MP0000432_abnormal_head_morphology	0.16974199
75	MP0003638_abnormal_response/metabolism_	0.16424955
76	MP0003300_gastrointestinal_ulcer	0.16024740
77	MP0003448_altered_tumor_morphology	0.15065622
78	MP0004742_abnormal_vestibular_system	0.15031560
79	MP0002166_altered_tumor_susceptibility	0.13951428
80	MP0003935_abnormal_craniofacial_develop	0.13516827
81	MP0005375_adipose_tissue_phenotype	0.13366021
82	MP0002006_tumorigenesis	0.13306649
83	MP0004858_abnormal_nervous_system	0.13173578
84	MP0003075_altered_response_to	0.12172350
85	MP0001958_emphysema	0.11105807
86	MP0001879_abnormal_lymphatic_vessel	0.10235296
87	MP0009384_cardiac_valve_regurgitation	0.09715718
88	MP0003011_delayed_dark_adaptation	0.09126444
89	MP0002233_abnormal_nose_morphology	0.08342208
90	MP0005076_abnormal_cell_differentiation	0.08316482
91	MP0005193_abnormal_anterior_eye	0.08231139
92	MP0003045_fibrosis	0.07700006
93	MP0002909_abnormal_adrenal_gland	0.06986809
94	MP0008569_lethality_at_weaning	0.06758208
95	MP0000751_myopathy	0.06716618
96	MP0005367_renal/urinary_system_phenotyp	0.06689351
97	MP0000516_abnormal_urinary_system	0.06689351
98	MP0000013_abnormal_adipose_tissue	0.05644477
99	MP0006138_congestive_heart_failure	0.05576126
100	MP0010368_abnormal_lymphatic_system	0.05339486

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.44611359
2	Nail dystrophy (HP:0008404)	7.67012421
3	Abnormality of nail color (HP:0100643)	6.15923387
4	Fragile nails (HP:0001808)	5.53028598
5	Fine hair (HP:0002213)	5.47295517
6	Abnormal hair laboratory examination (HP:0003328)	5.34459760
7	Alopecia of scalp (HP:0002293)	5.01696349
8	Palmoplantar hyperkeratosis (HP:0000972)	4.79677905
9	Thick nail (HP:0001805)	4.51931005
10	Palmar hyperkeratosis (HP:0010765)	4.51374867
11	Plantar hyperkeratosis (HP:0007556)	4.36356082
12	Onycholysis (HP:0001806)	4.35837165
13	Increased IgE level (HP:0003212)	4.10337090
14	Follicular hyperkeratosis (HP:0007502)	4.09587791
15	Right ventricular cardiomyopathy (HP:0011663)	3.99835016
16	Sparse eyelashes (HP:0000653)	3.39478136
17	Oral leukoplakia (HP:0002745)	3.32797709
18	Erythema (HP:0010783)	3.31816427
19	Parakeratosis (HP:0001036)	3.18689004
20	Milia (HP:0001056)	3.17477296
21	Abnormality of the frontal sinuses (HP:0002687)	3.07059415
22	Erythroderma (HP:0001019)	2.97466634
23	Amelogenesis imperfecta (HP:0000705)	2.94688098
24	Congenital ichthyosiform erythroderma (HP:0007431)	2.69744990
25	Ridged nail (HP:0001807)	2.68064025
26	Curly hair (HP:0002212)	2.64018023
27	Intention tremor (HP:0002080)	2.59020993
28	Dry hair (HP:0011359)	2.49581730
29	Congenital, generalized hypertrichosis (HP:0004540)	2.43791380
30	Aplasia cutis congenita (HP:0001057)	2.39369049
31	Neck muscle weakness (HP:0000467)	2.38593131
32	Abnormal blistering of the skin (HP:0008066)	2.37834685
33	Torticollis (HP:0000473)	2.34210324
34	Natal tooth (HP:0000695)	2.24465358
35	Corneal erosion (HP:0200020)	2.15389181
36	Hypohidrosis (HP:0000966)	2.14862762
37	Advanced eruption of teeth (HP:0006288)	2.11769004
38	Palmoplantar keratoderma (HP:0000982)	2.06343401
39	Hypotrichosis (HP:0001006)	15.2504427
40	Slow-growing hair (HP:0002217)	11.6122503
41	Abnormality of hair growth rate (HP:0011363)	11.6122503
42	Brittle hair (HP:0002299)	10.8910564
43	Woolly hair (HP:0002224)	10.8509795
44	Craniofacial dystonia (HP:0012179)	1.98690013
45	Ventricular tachycardia (HP:0004756)	1.91740335
46	Pruritus (HP:0000989)	1.87667280
47	Concave nail (HP:0001598)	1.84604571
48	Abnormality of the pupil (HP:0000615)	1.84037892
49	Focal dystonia (HP:0004373)	1.82081437
50	Difficulty walking (HP:0002355)	1.80243204
51	Abnormality of the parietal bone (HP:0002696)	1.73351210
52	Ventricular fibrillation (HP:0001663)	1.72195885
53	Abnormality of dental color (HP:0011073)	1.71457197
54	Conjunctival hamartoma (HP:0100780)	1.71283592
55	Abnormality of permanent molar morphology (HP:0011071)	1.69902300
56	Abnormality of the dental root (HP:0006486)	1.69902300
57	Taurodontia (HP:0000679)	1.69902300
58	Abnormality of molar (HP:0011077)	1.67327483
59	Abnormality of molar morphology (HP:0011070)	1.67327483
60	Widely patent fontanelles and sutures (HP:0004492)	1.66486672
61	Hyporeflexia of lower limbs (HP:0002600)	1.65219398
62	Absent eyelashes (HP:0000561)	1.63446859
63	Recurrent corneal erosions (HP:0000495)	1.62643885
64	Fatigable weakness (HP:0003473)	1.62128915
65	Abnormality of the neuromuscular junction (HP:0003398)	1.62128915
66	Blepharitis (HP:0000498)	1.52973199
67	Abnormality of the dental pulp (HP:0006479)	1.48232945
68	Amniotic constriction ring (HP:0009775)	1.48178840
69	Abnormality of placental membranes (HP:0011409)	1.48178840
70	Heterogeneous (HP:0001425)	1.47561207
71	Acanthosis nigricans (HP:0000956)	1.42980930
72	Keratoconjunctivitis sicca (HP:0001097)	1.41842530
73	Sudden death (HP:0001699)	1.41635479
74	Gangrene (HP:0100758)	1.40196871
75	Lip pit (HP:0100267)	1.39613915
76	Achilles tendon contracture (HP:0001771)	1.39376811
77	Distal lower limb muscle weakness (HP:0009053)	1.37836822
78	Carious teeth (HP:0000670)	1.36868414
79	Ectropion (HP:0000656)	1.36580129
80	Autoamputation (HP:0001218)	1.34516445
81	Abnormality of the Achilles tendon (HP:0005109)	1.31943557
82	Anonychia (HP:0001798)	1.28655040
83	Craniofacial hyperostosis (HP:0004493)	1.27780843
84	Neonatal onset (HP:0003623)	1.27761975
85	Variable expressivity (HP:0003828)	1.27428553
86	Abnormality of the aortic arch (HP:0012303)	1.26399211
87	Unilateral renal agenesis (HP:0000122)	1.26339452
88	Abnormality of the fingernails (HP:0001231)	1.25992677
89	Lack of skin elasticity (HP:0100679)	1.24713198
90	Keratoconjunctivitis (HP:0001096)	1.24686124
91	Round ear (HP:0100830)	1.24598088
92	Atrophic scars (HP:0001075)	1.23012076
93	Hypergammaglobulinemia (HP:0010702)	1.18487138
94	Increased connective tissue (HP:0009025)	1.13916491
95	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.11379515
96	Hyperhidrosis (HP:0000975)	1.10952251
97	Widely spaced teeth (HP:0000687)	1.10466971
98	Laryngomalacia (HP:0001601)	1.09767399
99	Bronchomalacia (HP:0002780)	1.09245731
100	Selective tooth agenesis (HP:0001592)	1.09172024

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.41699678
2	MAPKAPK3	4.20591036
3	ERN1	3.87552145
4	FER	3.79969030
5	MAP3K6	3.38122282
6	EPHB2	3.04151616
7	TAOK1	2.89074815
8	MAP3K3	2.75278497
9	TRIB3	2.59786346
10	LATS1	2.49940128
11	MAP3K2	2.46064762
12	RPS6KB2	2.01382236
13	MAP3K11	1.98454060
14	MAP2K6	1.97534660
15	TTN	1.78282424
16	LATS2	1.70645744
17	PIK3CG	1.65104445
18	EEF2K	1.63531335
19	EPHB1	1.55296156
20	FGFR2	1.49959784
21	NME1	1.45688398
22	BCR	1.36592750
23	MST1R	1.35228518
24	KSR2	1.32612751
25	MAP3K1	1.29076366
26	RIPK1	1.23902114
27	FGFR4	1.23505374
28	FGFR1	1.22164781
29	MAP2K3	1.19503109
30	CDK6	1.16468758
31	BMX	1.15370895
32	BLK	1.14375655
33	PKN2	1.13602835
34	LRRK2	1.10099464
35	PBK	1.09232999
36	FGFR3	1.04655823
37	PDGFRA	1.04304134
38	MAP3K9	1.03768270
39	MAPKAPK2	1.03603181
40	PTK6	1.01722214
41	MAP3K7	0.96089469
42	MAP2K4	0.93681273
43	MAP2K1	0.85077500
44	STK38	0.78994286
45	RPS6KA4	0.77875281
46	PAK3	0.75649628
47	PIM2	0.75579492
48	PTK2	0.74957446
49	DDR2	0.74674110
50	TESK1	0.74167598
51	MET	0.73786039
52	SIK1	0.71451534
53	PRKD1	0.69949147
54	CDK19	0.68896588
55	PAK4	0.68189486
56	NTRK2	0.67118605
57	STK38L	0.66585291
58	DYRK1B	0.65949382
59	ERBB4	0.64741233
60	TYRO3	0.58287727
61	TGFBR1	0.57997509
62	PRKCH	0.56664624
63	MAP3K5	0.56472287
64	TRPM7	0.55833827
65	ALK	0.54268875
66	ERBB3	0.54170160
67	PRKCI	0.53830320
68	RET	0.52793894
69	PAK6	0.50891508
70	NEK1	0.49167440
71	MST4	0.49166312
72	JAK1	0.47537789
73	ERBB2	0.47470057
74	MAPK12	0.44073810
75	PAK2	0.43717606
76	TYK2	0.42432263
77	CSNK1E	0.42164678
78	GSK3A	0.41952402
79	MAP3K10	0.41669682
80	ILK	0.40752627
81	RPS6KA1	0.40471912
82	MAP2K2	0.40461186
83	EPHA3	0.40055277
84	JAK2	0.40026662
85	LIMK1	0.39766229
86	GRK6	0.30184820
87	FYN	0.29544029
88	ROCK2	0.28403332
89	SRC	0.27052669
90	MAP3K8	0.26674240
91	CSNK1A1L	0.26604340
92	CSNK1A1	0.25155957
93	PHKG1	0.24501567
94	PHKG2	0.24501567
95	EPHA4	0.24262127
96	HCK	0.24058143
97	TGFBR2	0.23379887
98	CSNK1D	0.23162420
99	PRKACG	0.23091879
100	MAPKAPK5	0.22156913

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.88811868
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.86058655
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.08759260
4	Fatty acid elongation_Homo sapiens_hsa00062	2.67902975
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.58285266
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.05022051
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.90840003
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.81996791
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.75923886
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.75419294
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.63290267
12	Melanogenesis_Homo sapiens_hsa04916	1.55988742
13	Axon guidance_Homo sapiens_hsa04360	1.51881630
14	Histidine metabolism_Homo sapiens_hsa00340	1.43289282
15	Bladder cancer_Homo sapiens_hsa05219	1.35512114
16	Glioma_Homo sapiens_hsa05214	1.32492769
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.31455759
18	GnRH signaling pathway_Homo sapiens_hsa04912	1.29596429
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.27840256
20	Thyroid cancer_Homo sapiens_hsa05216	1.27788711
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.25460492
22	Caffeine metabolism_Homo sapiens_hsa00232	1.25167800
23	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.22704614
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.18250016
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.16507736
26	Long-term potentiation_Homo sapiens_hsa04720	1.11667542
27	Pancreatic secretion_Homo sapiens_hsa04972	1.11565231
28	Tight junction_Homo sapiens_hsa04530	1.06519089
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.04888708
30	Mineral absorption_Homo sapiens_hsa04978	1.04069250
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.04060739
32	Acute myeloid leukemia_Homo sapiens_hsa05221	1.01634113
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97514668
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96735891
35	ECM-receptor interaction_Homo sapiens_hsa04512	0.92549129
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.92146826
37	Pertussis_Homo sapiens_hsa05133	0.89827190
38	Long-term depression_Homo sapiens_hsa04730	0.88887777
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.88779323
40	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.86892563
41	Non-small cell lung cancer_Homo sapiens_hsa05223	0.84124191
42	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83560910
43	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83279993
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.83153775
45	Ras signaling pathway_Homo sapiens_hsa04014	0.83020063
46	Adherens junction_Homo sapiens_hsa04520	0.82986919
47	Endometrial cancer_Homo sapiens_hsa05213	0.80234850
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80174602
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.77671593
50	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.77242303
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.77155628
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73645846
53	Amoebiasis_Homo sapiens_hsa05146	0.71578591
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.71488476
55	Renin secretion_Homo sapiens_hsa04924	0.71453061
56	Wnt signaling pathway_Homo sapiens_hsa04310	0.70987451
57	Gastric acid secretion_Homo sapiens_hsa04971	0.69694448
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66086195
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65449643
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.61678210
61	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.61475461
62	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59256218
63	Gap junction_Homo sapiens_hsa04540	0.58825489
64	Phototransduction_Homo sapiens_hsa04744	0.58113822
65	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56131616
66	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55988740
67	Hepatitis C_Homo sapiens_hsa05160	0.55843275
68	Butanoate metabolism_Homo sapiens_hsa00650	0.55650955
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54402773
70	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.54129006
71	Insulin resistance_Homo sapiens_hsa04931	0.53809405
72	Salmonella infection_Homo sapiens_hsa05132	0.53614417
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53572913
74	Salivary secretion_Homo sapiens_hsa04970	0.50758226
75	Fatty acid degradation_Homo sapiens_hsa00071	0.50479596
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.50399141
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50310879
78	Platelet activation_Homo sapiens_hsa04611	0.49513598
79	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.49402930
80	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.48663015
81	Renal cell carcinoma_Homo sapiens_hsa05211	0.47682534
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46908255
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46767403
84	Focal adhesion_Homo sapiens_hsa04510	0.46551844
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45414651
86	ErbB signaling pathway_Homo sapiens_hsa04012	0.45323151
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44828853
88	Prion diseases_Homo sapiens_hsa05020	0.44183988
89	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.43711848
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41628110
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.40661778
92	Olfactory transduction_Homo sapiens_hsa04740	0.39439040
93	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.38241901
94	p53 signaling pathway_Homo sapiens_hsa04115	0.37668000
95	Tuberculosis_Homo sapiens_hsa05152	0.37520132
96	Complement and coagulation cascades_Homo sapiens_hsa04610	0.36094701
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.35649356
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.34606945
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33911501
100	Toxoplasmosis_Homo sapiens_hsa05145	0.32543364

KRTAP19-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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