ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	9.73307360
2	virion attachment to host cell (GO:0019062)	9.73307360
3	citrulline biosynthetic process (GO:0019240)	8.65541118
4	peptide cross-linking (GO:0018149)	8.60606994
5	hair follicle morphogenesis (GO:0031069)	8.31509252
6	adhesion of symbiont to host (GO:0044406)	8.19397897
7	intermediate filament cytoskeleton organization (GO:0045104)	6.84041771
8	intermediate filament-based process (GO:0045103)	6.62063811
9	epidermis development (GO:0008544)	6.34600797
10	establishment of skin barrier (GO:0061436)	6.12577732
11	cell wall macromolecule metabolic process (GO:0044036)	6.07729942
12	cell wall macromolecule catabolic process (GO:0016998)	6.07729942
13	keratinocyte differentiation (GO:0030216)	5.88190013
14	citrulline metabolic process (GO:0000052)	5.72610390
15	regulation of water loss via skin (GO:0033561)	5.42992416
16	hair cycle process (GO:0022405)	5.39233128
17	molting cycle process (GO:0022404)	5.39233128
18	hemidesmosome assembly (GO:0031581)	5.02023770
19	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.00700561
20	peptidyl-arginine modification (GO:0018195)	4.77266202
21	skin morphogenesis (GO:0043589)	4.61585979
22	epidermal cell differentiation (GO:0009913)	4.58087310
23	hair cycle (GO:0042633)	34.3725307
24	molting cycle (GO:0042303)	34.3725307
25	keratinocyte development (GO:0003334)	3.87166691
26	tooth mineralization (GO:0034505)	3.75612340
27	multicellular organismal water homeostasis (GO:0050891)	3.63274461
28	regulation of keratinocyte differentiation (GO:0045616)	3.45121040
29	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.39006663
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.35574753
31	hair follicle development (GO:0001942)	3.24135809
32	positive regulation of hair cycle (GO:0042635)	3.22297063
33	positive regulation of hair follicle development (GO:0051798)	3.22297063
34	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.11159997
35	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.08996272
36	bone trabecula formation (GO:0060346)	3.08944822
37	epithelium development (GO:0060429)	3.00491132
38	regulation of hair follicle development (GO:0051797)	2.99014610
39	water homeostasis (GO:0030104)	2.97963805
40	gap junction assembly (GO:0016264)	2.93189236
41	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.86035672
42	positive regulation of meiotic cell cycle (GO:0051446)	2.85937462
43	regulation of hair cycle (GO:0042634)	2.76225947
44	ectoderm development (GO:0007398)	2.70684463
45	positive regulation of epidermis development (GO:0045684)	2.69237422
46	regulation of epidermal cell differentiation (GO:0045604)	2.65836653
47	fatty acid elongation (GO:0030497)	2.64925034
48	negative regulation of protein localization to plasma membrane (GO:1903077)	2.58117916
49	regulation of epidermis development (GO:0045682)	2.51997920
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.50718693
51	atrioventricular valve morphogenesis (GO:0003181)	2.45566054
52	positive regulation of monocyte chemotaxis (GO:0090026)	2.37714797
53	phosphatidylserine metabolic process (GO:0006658)	2.33097398
54	wound healing, spreading of epidermal cells (GO:0035313)	2.32226748
55	ventricular cardiac muscle cell action potential (GO:0086005)	2.30117303
56	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.26954676
57	cranial suture morphogenesis (GO:0060363)	2.26309448
58	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.26308505
59	positive regulation of epidermal cell differentiation (GO:0045606)	2.21840119
60	negative regulation of cell fate specification (GO:0009996)	2.18472384
61	skin development (GO:0043588)	2.15750737
62	regulation of ruffle assembly (GO:1900027)	2.11379437
63	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.11275952
64	aging (GO:0007568)	2.02084444
65	negative regulation of epidermis development (GO:0045683)	2.01793665
66	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.00382622
67	keratinization (GO:0031424)	12.2872487
68	intermediate filament organization (GO:0045109)	12.2426866
69	desmosome organization (GO:0002934)	10.2387215
70	epithelial cell-cell adhesion (GO:0090136)	1.95152212
71	lymph vessel development (GO:0001945)	1.94516369
72	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.94253381
73	regulation of heart rate by cardiac conduction (GO:0086091)	1.92473187
74	regulation of cardioblast differentiation (GO:0051890)	1.92123371
75	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.90765596
76	ephrin receptor signaling pathway (GO:0048013)	1.90756921
77	outflow tract septum morphogenesis (GO:0003148)	1.87757115
78	regulation of keratinocyte proliferation (GO:0010837)	1.87599968
79	cell communication involved in cardiac conduction (GO:0086065)	1.85799461
80	myotube differentiation (GO:0014902)	1.85564049
81	keratinocyte proliferation (GO:0043616)	1.83416561
82	cell-substrate junction assembly (GO:0007044)	1.82177904
83	non-canonical Wnt signaling pathway (GO:0035567)	1.81345716
84	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.78662791
85	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.75040544
86	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.74798226
87	alditol phosphate metabolic process (GO:0052646)	1.71424052
88	regulation of monocyte chemotaxis (GO:0090025)	1.69920116
89	very long-chain fatty acid metabolic process (GO:0000038)	1.68912520
90	primary alcohol catabolic process (GO:0034310)	1.66739952
91	negative regulation of epidermal cell differentiation (GO:0045605)	1.65581982
92	craniofacial suture morphogenesis (GO:0097094)	1.63729372
93	establishment of tissue polarity (GO:0007164)	1.63728259
94	establishment of planar polarity (GO:0001736)	1.63728259
95	wound healing, spreading of cells (GO:0044319)	1.62101616
96	response to UV-B (GO:0010224)	1.59644387
97	eyelid development in camera-type eye (GO:0061029)	1.56919886
98	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.56685328
99	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.56264300
100	positive regulation of protein export from nucleus (GO:0046827)	1.55850025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.88978328
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.06053346
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.62892276
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.76339757
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.36210136
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.08670106
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.02357537
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.7789325
9	TAF2_19829295_ChIP-Seq_ESCs_Human	1.83873583
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.83692193
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.83680430
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.75345374
13	EGR1_19032775_ChIP-ChIP_M12_Human	1.73709108
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.72717549
15	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.72113660
16	ERG_20517297_ChIP-Seq_VCAP_Human	1.69832575
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.69805199
18	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.69580672
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.63678699
20	CTCF_27219007_Chip-Seq_Bcells_Human	1.58907947
21	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.56799276
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.52530304
23	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.52363593
24	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.52363593
25	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.51806886
26	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.49944585
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.49502573
28	TP63_22573176_ChIP-Seq_HFKS_Human	1.49298631
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.45993353
30	BCOR_27268052_Chip-Seq_Bcells_Human	1.44615212
31	LXR_22292898_ChIP-Seq_THP-1_Human	1.43011757
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40713684
33	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.40695240
34	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.38905929
35	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.37815005
36	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.35441698
37	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.34051592
38	ATF3_27146783_Chip-Seq_COLON_Human	1.33973924
39	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33794733
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27934334
41	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.27539284
42	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.26743393
43	AHR_22903824_ChIP-Seq_MCF-7_Human	1.26172170
44	PHF8_20622854_ChIP-Seq_HELA_Human	1.24927236
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.24626750
46	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.24310122
47	P68_20966046_ChIP-Seq_HELA_Human	1.22670933
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20514472
49	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20177071
50	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.17512066
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17148466
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.16162389
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15807482
54	TP63_23658742_ChIP-Seq_EP156T_Human	1.15766299
55	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11024672
56	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.10455909
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.09612629
58	TP53_18474530_ChIP-ChIP_U2OS_Human	1.08925195
59	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07671338
60	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06793476
61	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.06533010
62	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05414808
63	GATA4_25053715_ChIP-Seq_YYC3_Human	1.05201820
64	SMC4_20622854_ChIP-Seq_HELA_Human	1.04001762
65	SOX2_21211035_ChIP-Seq_LN229_Human	1.03565882
66	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.02975797
67	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02200178
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.02074502
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01590642
70	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.01303959
71	SPI1_20517297_ChIP-Seq_HL60_Human	1.00655326
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97902974
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97075266
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.95443824
75	KLF5_25053715_ChIP-Seq_YYC3_Human	0.95097271
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93352024
77	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91616777
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.90438680
79	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90415240
80	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.89951220
81	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.89131643
82	RXR_22108803_ChIP-Seq_LS180_Human	0.89028149
83	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.88314868
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88162363
85	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.87601669
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86102582
87	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.86068850
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.84168533
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80258494
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.80183669
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.79924957
92	ZNF263_19887448_ChIP-Seq_K562_Human	0.79011524
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.77261399
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.76090337
95	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.75917961
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.75898588
97	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.75898588
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.73766975
99	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.73066599
100	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.73011579

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.57158032
2	MP0002098_abnormal_vibrissa_morphology	7.11567739
3	MP0000647_abnormal_sebaceous_gland	6.32429826
4	MP0002796_impaired_skin_barrier	5.96089443
5	MP0005275_abnormal_skin_tensile	5.19959053
6	MP0010234_abnormal_vibrissa_follicle	5.07549358
7	MP0000383_abnormal_hair_follicle	4.66500833
8	MP0010678_abnormal_skin_adnexa	4.12906017
9	MP0000377_abnormal_hair_follicle	4.02762503
10	MP0005501_abnormal_skin_physiology	3.71046560
11	MP0003705_abnormal_hypodermis_morpholog	3.66557100
12	MP0000427_abnormal_hair_cycle	3.45108971
13	MP0002254_reproductive_system_inflammat	3.19207530
14	MP0001216_abnormal_epidermal_layer	2.69870844
15	MP0004381_abnormal_hair_follicle	2.50590128
16	MP0000367_abnormal_coat/_hair	2.37216473
17	MP0010771_integument_phenotype	2.35772346
18	MP0004947_skin_inflammation	2.30411606
19	MP0002060_abnormal_skin_morphology	2.24074350
20	MP0003453_abnormal_keratinocyte_physiol	2.19844273
21	MP0001243_abnormal_dermal_layer	2.12568315
22	MP0002234_abnormal_pharynx_morphology	1.90488691
23	MP0000467_abnormal_esophagus_morphology	1.77268935
24	MP0009931_abnormal_skin_appearance	1.53564264
25	MP0009053_abnormal_anal_canal	1.51072916
26	MP0000762_abnormal_tongue_morphology	1.50269199
27	MP0003566_abnormal_cell_adhesion	1.45283047
28	MP0003941_abnormal_skin_development	1.33398323
29	MP0005409_darkened_coat_color	1.31136172
30	MP0001191_abnormal_skin_condition	1.01621396
31	MP0004885_abnormal_endolymph	1.01187635
32	MP0004185_abnormal_adipocyte_glucose	0.98779813
33	MP0004264_abnormal_extraembryonic_tissu	0.92922820
34	MP0008438_abnormal_cutaneous_collagen	0.91149074
35	MP0002095_abnormal_skin_pigmentation	0.83648744
36	MP0001851_eye_inflammation	0.74152335
37	MP0003315_abnormal_perineum_morphology	0.67869054
38	MP0001346_abnormal_lacrimal_gland	0.66625629
39	MP0002877_abnormal_melanocyte_morpholog	0.66049239
40	MP0000566_synostosis	0.64504421
41	MP0001661_extended_life_span	0.64327186
42	MP0001340_abnormal_eyelid_morphology	0.63912848
43	MP0010030_abnormal_orbit_morphology	0.61599181
44	MP0001849_ear_inflammation	0.61178739
45	MP0003191_abnormal_cellular_cholesterol	0.58765789
46	MP0009379_abnormal_foot_pigmentation	0.57377419
47	MP0000627_abnormal_mammary_gland	0.55791535
48	MP0002282_abnormal_trachea_morphology	0.52142887
49	MP0005451_abnormal_body_composition	0.50518479
50	MP0005023_abnormal_wound_healing	0.49067559
51	MP0003755_abnormal_palate_morphology	0.47981690
52	MP0001784_abnormal_fluid_regulation	0.44855062
53	MP0002970_abnormal_white_adipose	0.44745157
54	MP0002111_abnormal_tail_morphology	0.40463197
55	MP0010352_gastrointestinal_tract_polyps	0.36683109
56	MP0004272_abnormal_basement_membrane	0.33142451
57	MP0000537_abnormal_urethra_morphology	0.32045761
58	MP0002177_abnormal_outer_ear	0.31709246
59	MP0003385_abnormal_body_wall	0.31597063
60	MP0002249_abnormal_larynx_morphology	0.29589641
61	MP0009840_abnormal_foam_cell	0.28168955
62	MP0005075_abnormal_melanosome_morpholog	0.27971471
63	MP0003950_abnormal_plasma_membrane	0.25355709
64	MP0003329_amyloid_beta_deposits	0.25306679
65	MP0002697_abnormal_eye_size	0.24624052
66	MP0003763_abnormal_thymus_physiology	0.23310232
67	MP0000465_gastrointestinal_hemorrhage	0.22882334
68	MP0005248_abnormal_Harderian_gland	0.21684628
69	MP0006054_spinal_hemorrhage	0.20710599
70	MP0000678_abnormal_parathyroid_gland	0.19557900
71	MP0000432_abnormal_head_morphology	0.19030908
72	MP0005666_abnormal_adipose_tissue	0.18093039
73	MP0002166_altered_tumor_susceptibility	0.17413916
74	MP0003300_gastrointestinal_ulcer	0.17263242
75	MP0002006_tumorigenesis	0.16457897
76	MP0004019_abnormal_vitamin_homeostasis	0.16275658
77	MP0000604_amyloidosis	0.14831583
78	MP0003935_abnormal_craniofacial_develop	0.14815059
79	MP0003638_abnormal_response/metabolism_	0.14728192
80	MP0003448_altered_tumor_morphology	0.14246824
81	MP0004742_abnormal_vestibular_system	0.13460581
82	MP0005375_adipose_tissue_phenotype	0.13444905
83	MP0009384_cardiac_valve_regurgitation	0.13443342
84	MP0001958_emphysema	0.11062737
85	MP0004858_abnormal_nervous_system	0.10632378
86	MP0001879_abnormal_lymphatic_vessel	0.10057626
87	MP0005076_abnormal_cell_differentiation	0.09961888
88	MP0003075_altered_response_to	0.09720054
89	MP0000516_abnormal_urinary_system	0.09713351
90	MP0005367_renal/urinary_system_phenotyp	0.09713351
91	MP0005193_abnormal_anterior_eye	0.08996084
92	MP0002233_abnormal_nose_morphology	0.08436222
93	MP0002009_preneoplasia	0.07902073
94	MP0000751_myopathy	0.07811079
95	MP0003011_delayed_dark_adaptation	0.07768962
96	MP0003045_fibrosis	0.07488223
97	MP0000013_abnormal_adipose_tissue	0.06156555
98	MP0005508_abnormal_skeleton_morphology	0.05915612
99	MP0008569_lethality_at_weaning	0.05816882
100	MP0000428_abnormal_craniofacial_morphol	0.05572658

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.68143117
2	Nail dystrophy (HP:0008404)	7.53297522
3	Abnormality of nail color (HP:0100643)	6.22722674
4	Fragile nails (HP:0001808)	5.55304047
5	Abnormal hair laboratory examination (HP:0003328)	5.48974556
6	Fine hair (HP:0002213)	5.40893487
7	Alopecia of scalp (HP:0002293)	5.05308594
8	Palmoplantar hyperkeratosis (HP:0000972)	4.77847044
9	Palmar hyperkeratosis (HP:0010765)	4.49767680
10	Thick nail (HP:0001805)	4.47941321
11	Onycholysis (HP:0001806)	4.39629647
12	Plantar hyperkeratosis (HP:0007556)	4.35317431
13	Follicular hyperkeratosis (HP:0007502)	4.34967850
14	Increased IgE level (HP:0003212)	4.08337272
15	Right ventricular cardiomyopathy (HP:0011663)	4.02726994
16	Sparse eyelashes (HP:0000653)	3.49046879
17	Oral leukoplakia (HP:0002745)	3.37140211
18	Erythema (HP:0010783)	3.36906666
19	Parakeratosis (HP:0001036)	3.21165860
20	Milia (HP:0001056)	3.16549595
21	Abnormality of the frontal sinuses (HP:0002687)	3.12853452
22	Amelogenesis imperfecta (HP:0000705)	2.99635172
23	Erythroderma (HP:0001019)	2.94214784
24	Congenital ichthyosiform erythroderma (HP:0007431)	2.69295675
25	Curly hair (HP:0002212)	2.66610286
26	Ridged nail (HP:0001807)	2.65989865
27	Congenital, generalized hypertrichosis (HP:0004540)	2.62331105
28	Intention tremor (HP:0002080)	2.58690749
29	Dry hair (HP:0011359)	2.47776402
30	Aplasia cutis congenita (HP:0001057)	2.43950273
31	Neck muscle weakness (HP:0000467)	2.40112961
32	Abnormal blistering of the skin (HP:0008066)	2.37765742
33	Torticollis (HP:0000473)	2.32530096
34	Natal tooth (HP:0000695)	2.25578370
35	Advanced eruption of teeth (HP:0006288)	2.14565942
36	Corneal erosion (HP:0200020)	2.14554478
37	Hypohidrosis (HP:0000966)	2.13524593
38	Palmoplantar keratoderma (HP:0000982)	2.06066711
39	Hypotrichosis (HP:0001006)	15.0252092
40	Slow-growing hair (HP:0002217)	11.4397534
41	Abnormality of hair growth rate (HP:0011363)	11.4397534
42	Woolly hair (HP:0002224)	10.9695332
43	Brittle hair (HP:0002299)	10.6787514
44	Craniofacial dystonia (HP:0012179)	1.96779483
45	Ventricular tachycardia (HP:0004756)	1.92846896
46	Pruritus (HP:0000989)	1.89646390
47	Concave nail (HP:0001598)	1.87713302
48	Abnormality of the pupil (HP:0000615)	1.84095348
49	Difficulty walking (HP:0002355)	1.80542083
50	Focal dystonia (HP:0004373)	1.80092906
51	Abnormality of the parietal bone (HP:0002696)	1.77412106
52	Abnormality of dental color (HP:0011073)	1.73735809
53	Abnormality of the dental root (HP:0006486)	1.73611492
54	Taurodontia (HP:0000679)	1.73611492
55	Abnormality of permanent molar morphology (HP:0011071)	1.73611492
56	Ventricular fibrillation (HP:0001663)	1.71682955
57	Abnormality of molar (HP:0011077)	1.71430051
58	Abnormality of molar morphology (HP:0011070)	1.71430051
59	Widely patent fontanelles and sutures (HP:0004492)	1.69410600
60	Absent eyelashes (HP:0000561)	1.68553355
61	Hyporeflexia of lower limbs (HP:0002600)	1.67249435
62	Recurrent corneal erosions (HP:0000495)	1.65642988
63	Conjunctival hamartoma (HP:0100780)	1.65538496
64	Fatigable weakness (HP:0003473)	1.59176354
65	Abnormality of the neuromuscular junction (HP:0003398)	1.59176354
66	Blepharitis (HP:0000498)	1.55129695
67	Abnormality of the dental pulp (HP:0006479)	1.51487254
68	Amniotic constriction ring (HP:0009775)	1.51397701
69	Abnormality of placental membranes (HP:0011409)	1.51397701
70	Acanthosis nigricans (HP:0000956)	1.44632529
71	Lip pit (HP:0100267)	1.44585600
72	Keratoconjunctivitis sicca (HP:0001097)	1.44384780
73	Heterogeneous (HP:0001425)	1.44118960
74	Sudden death (HP:0001699)	1.41153871
75	Carious teeth (HP:0000670)	1.39070746
76	Achilles tendon contracture (HP:0001771)	1.37838932
77	Gangrene (HP:0100758)	1.37193841
78	Distal lower limb muscle weakness (HP:0009053)	1.37010300
79	Ectropion (HP:0000656)	1.36269086
80	Autoamputation (HP:0001218)	1.35871550
81	Craniofacial hyperostosis (HP:0004493)	1.31571036
82	Anonychia (HP:0001798)	1.30325851
83	Round ear (HP:0100830)	1.30301738
84	Abnormality of the Achilles tendon (HP:0005109)	1.30136593
85	Unilateral renal agenesis (HP:0000122)	1.28561047
86	Abnormality of the aortic arch (HP:0012303)	1.27881132
87	Atrophic scars (HP:0001075)	1.27754699
88	Keratoconjunctivitis (HP:0001096)	1.26996991
89	Abnormality of the fingernails (HP:0001231)	1.26805831
90	Neonatal onset (HP:0003623)	1.23621347
91	Lack of skin elasticity (HP:0100679)	1.23433352
92	Variable expressivity (HP:0003828)	1.23177423
93	Increased connective tissue (HP:0009025)	1.18416849
94	Hypergammaglobulinemia (HP:0010702)	1.17072190
95	Type 1 muscle fiber predominance (HP:0003803)	1.15259513
96	Widely spaced teeth (HP:0000687)	1.14198216
97	Laryngomalacia (HP:0001601)	1.12137056
98	Sparse scalp hair (HP:0002209)	1.10664360
99	Selective tooth agenesis (HP:0001592)	1.10494237
100	Hyperhidrosis (HP:0000975)	1.09968026

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.38197487
2	MAPKAPK3	4.16052296
3	FER	3.84295881
4	ERN1	3.81861550
5	MAP3K6	3.37621246
6	EPHB2	3.09831462
7	TAOK1	2.90071709
8	MAP3K3	2.77990601
9	LATS1	2.64400178
10	TRIB3	2.58155416
11	MAP3K2	2.48798647
12	RPS6KB2	2.00333683
13	MAP3K11	1.97527240
14	MAP2K6	1.91357970
15	TTN	1.85711995
16	PIK3CG	1.77491714
17	LATS2	1.69929576
18	FGFR2	1.66268642
19	EEF2K	1.62650431
20	EPHB1	1.52547411
21	BCR	1.44282598
22	NME1	1.41614402
23	MST1R	1.34395722
24	FGFR1	1.29875531
25	KSR2	1.28981378
26	MAP3K1	1.27930330
27	RIPK1	1.22776091
28	CDK6	1.20689435
29	FGFR4	1.20199290
30	MAP2K3	1.19440213
31	FGFR3	1.15202237
32	BMX	1.13459032
33	PBK	1.11635626
34	PKN2	1.10314453
35	BLK	1.08885480
36	PDGFRA	1.07622445
37	LRRK2	1.07562032
38	MAPKAPK2	1.03857105
39	PTK6	1.02578456
40	MAP3K7	0.98806999
41	MAP3K9	0.98099720
42	MAP2K4	0.91395747
43	MAP2K1	0.82418894
44	RPS6KA4	0.81390968
45	STK38	0.78532035
46	PTK2	0.75527421
47	MET	0.73962684
48	SIK1	0.73634924
49	PIM2	0.72981937
50	DDR2	0.72724325
51	PAK3	0.71983376
52	TESK1	0.71246999
53	STK38L	0.70417778
54	PRKD1	0.69200374
55	DYRK1B	0.68380444
56	ERBB4	0.67201249
57	PAK4	0.66355884
58	CDK19	0.65409617
59	NTRK2	0.64643839
60	TRPM7	0.59334563
61	TGFBR1	0.57665315
62	MAP3K5	0.57472813
63	TYRO3	0.56091846
64	PRKCH	0.55118307
65	ERBB3	0.54538343
66	NEK1	0.53545174
67	PRKCI	0.53176589
68	RET	0.51468924
69	ALK	0.49882709
70	MST4	0.49036655
71	ERBB2	0.48888061
72	PAK6	0.47133225
73	JAK1	0.46130673
74	MAPK12	0.43243825
75	PAK2	0.43211766
76	MAP3K10	0.43186964
77	CSNK1E	0.42375086
78	GSK3A	0.42289690
79	RPS6KA1	0.40787329
80	EPHA3	0.40358109
81	TYK2	0.40068720
82	JAK2	0.38368358
83	MAP2K2	0.37759927
84	LIMK1	0.37401228
85	ILK	0.37299152
86	OBSCN	0.30435457
87	FYN	0.28545330
88	CSNK1A1L	0.27525501
89	PHKG1	0.26787099
90	PHKG2	0.26787099
91	SRC	0.26252013
92	MAP3K8	0.26194196
93	ROCK2	0.25894868
94	TGFBR2	0.25196709
95	GRK6	0.25071896
96	CSNK1A1	0.24889341
97	CSNK1D	0.23742446
98	PRKACG	0.22695645
99	MARK3	0.22514030
100	HCK	0.21923697

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.79335550
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.76587826
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.03167213
4	Fatty acid elongation_Homo sapiens_hsa00062	2.72442972
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.53139794
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.15122632
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.85108200
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.80317163
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.75865192
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.74724862
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.69206171
12	Melanogenesis_Homo sapiens_hsa04916	1.59844144
13	Axon guidance_Homo sapiens_hsa04360	1.53832718
14	Histidine metabolism_Homo sapiens_hsa00340	1.40512030
15	Bladder cancer_Homo sapiens_hsa05219	1.39740884
16	Glioma_Homo sapiens_hsa05214	1.35851986
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.34492227
18	Thyroid cancer_Homo sapiens_hsa05216	1.32239854
19	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30448719
20	Proteoglycans in cancer_Homo sapiens_hsa05205	1.30108087
21	GnRH signaling pathway_Homo sapiens_hsa04912	1.29007882
22	Hippo signaling pathway_Homo sapiens_hsa04390	1.25975661
23	Caffeine metabolism_Homo sapiens_hsa00232	1.24274267
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.21899393
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.12506211
26	Long-term potentiation_Homo sapiens_hsa04720	1.11677706
27	Tight junction_Homo sapiens_hsa04530	1.11509718
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10147443
29	Pancreatic secretion_Homo sapiens_hsa04972	1.09451757
30	Mineral absorption_Homo sapiens_hsa04978	1.08853181
31	Acute myeloid leukemia_Homo sapiens_hsa05221	1.05382883
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04321313
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.99591584
34	ECM-receptor interaction_Homo sapiens_hsa04512	0.98081480
35	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.97855132
36	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.93115441
37	Adherens junction_Homo sapiens_hsa04520	0.91277040
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.89836396
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89113233
40	Long-term depression_Homo sapiens_hsa04730	0.89020814
41	Pertussis_Homo sapiens_hsa05133	0.88489050
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.87748643
43	Endometrial cancer_Homo sapiens_hsa05213	0.85961816
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.85002241
45	Ras signaling pathway_Homo sapiens_hsa04014	0.82999401
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82884416
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.80475741
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.78863266
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77475662
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.77245319
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.76646000
52	Amoebiasis_Homo sapiens_hsa05146	0.75001895
53	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.74971410
54	Renin secretion_Homo sapiens_hsa04924	0.70450526
55	Gastric acid secretion_Homo sapiens_hsa04971	0.68443854
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.67689121
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67194783
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66972906
59	MicroRNAs in cancer_Homo sapiens_hsa05206	0.64870786
60	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.64803769
61	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.63618441
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.61302536
63	Gap junction_Homo sapiens_hsa04540	0.58194636
64	Hepatitis C_Homo sapiens_hsa05160	0.57789383
65	Phototransduction_Homo sapiens_hsa04744	0.57406284
66	Insulin resistance_Homo sapiens_hsa04931	0.57147963
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57059883
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.55829854
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55641175
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.55205263
71	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54026539
72	Salmonella infection_Homo sapiens_hsa05132	0.52746883
73	Butanoate metabolism_Homo sapiens_hsa00650	0.52571016
74	Platelet activation_Homo sapiens_hsa04611	0.51668442
75	Focal adhesion_Homo sapiens_hsa04510	0.51448211
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51124900
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50645106
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49997928
79	Renal cell carcinoma_Homo sapiens_hsa05211	0.49746057
80	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.49343783
81	Salivary secretion_Homo sapiens_hsa04970	0.47776605
82	Fatty acid degradation_Homo sapiens_hsa00071	0.47679456
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47296789
84	ErbB signaling pathway_Homo sapiens_hsa04012	0.46807168
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45092375
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44430325
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43267591
88	p53 signaling pathway_Homo sapiens_hsa04115	0.42348671
89	Prion diseases_Homo sapiens_hsa05020	0.41654197
90	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41412261
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40678273
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39521659
93	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.37892384
94	Tuberculosis_Homo sapiens_hsa05152	0.37541626
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.36010443
96	Olfactory transduction_Homo sapiens_hsa04740	0.35929787
97	Toxoplasmosis_Homo sapiens_hsa05145	0.34210039
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.33585477
99	Complement and coagulation cascades_Homo sapiens_hsa04610	0.32938151
100	Melanoma_Homo sapiens_hsa05218	0.32763710

KRTAP19-3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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