ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.73375160
2	adhesion of symbiont to host cell (GO:0044650)	9.73375160
3	peptide cross-linking (GO:0018149)	8.69028591
4	hair follicle morphogenesis (GO:0031069)	8.43406351
5	citrulline biosynthetic process (GO:0019240)	8.22040090
6	adhesion of symbiont to host (GO:0044406)	8.15619364
7	intermediate filament cytoskeleton organization (GO:0045104)	6.79084119
8	cell wall macromolecule catabolic process (GO:0016998)	6.64540872
9	cell wall macromolecule metabolic process (GO:0044036)	6.64540872
10	intermediate filament-based process (GO:0045103)	6.56839742
11	epidermis development (GO:0008544)	6.47281620
12	establishment of skin barrier (GO:0061436)	6.34718421
13	keratinocyte differentiation (GO:0030216)	6.06729599
14	hair cycle process (GO:0022405)	5.72996596
15	molting cycle process (GO:0022404)	5.72996596
16	regulation of water loss via skin (GO:0033561)	5.62527120
17	citrulline metabolic process (GO:0000052)	5.43724234
18	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.87006421
19	epidermal cell differentiation (GO:0009913)	4.73816258
20	hemidesmosome assembly (GO:0031581)	4.65835731
21	peptidyl-arginine modification (GO:0018195)	4.52463358
22	skin morphogenesis (GO:0043589)	4.11358297
23	hair cycle (GO:0042633)	32.7194516
24	molting cycle (GO:0042303)	32.7194516
25	keratinocyte development (GO:0003334)	3.84893166
26	tooth mineralization (GO:0034505)	3.84428829
27	multicellular organismal water homeostasis (GO:0050891)	3.75399212
28	hair follicle development (GO:0001942)	3.74699873
29	regulation of keratinocyte differentiation (GO:0045616)	3.71339436
30	bone trabecula formation (GO:0060346)	3.53827287
31	positive regulation of hair follicle development (GO:0051798)	3.36548567
32	positive regulation of hair cycle (GO:0042635)	3.36548567
33	negative regulation of keratinocyte proliferation (GO:0010839)	3.36412923
34	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.31281595
35	gap junction assembly (GO:0016264)	3.20598439
36	positive regulation of meiotic cell cycle (GO:0051446)	3.17684178
37	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.12228662
38	regulation of hair follicle development (GO:0051797)	3.12123526
39	epithelium development (GO:0060429)	3.08379432
40	water homeostasis (GO:0030104)	3.07336663
41	regulation of hair cycle (GO:0042634)	2.99641676
42	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.97594948
43	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.89802181
44	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.78286881
45	regulation of epidermal cell differentiation (GO:0045604)	2.77849996
46	cranial suture morphogenesis (GO:0060363)	2.76871154
47	positive regulation of epidermis development (GO:0045684)	2.65887761
48	wound healing, spreading of epidermal cells (GO:0035313)	2.59731916
49	negative regulation of protein localization to plasma membrane (GO:1903077)	2.59684105
50	regulation of epidermis development (GO:0045682)	2.58389583
51	ectoderm development (GO:0007398)	2.54925928
52	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.49894564
53	fatty acid elongation (GO:0030497)	2.49114165
54	positive regulation of monocyte chemotaxis (GO:0090026)	2.46883285
55	atrioventricular valve morphogenesis (GO:0003181)	2.25538620
56	phosphatidylserine metabolic process (GO:0006658)	2.24702355
57	negative regulation of epidermis development (GO:0045683)	2.24321447
58	keratinocyte proliferation (GO:0043616)	2.23955857
59	ventricular cardiac muscle cell action potential (GO:0086005)	2.22603463
60	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.20638997
61	regulation of ruffle assembly (GO:1900027)	2.19183966
62	positive regulation of epidermal cell differentiation (GO:0045606)	2.14437135
63	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.11713364
64	skin development (GO:0043588)	2.08274530
65	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.06242800
66	negative regulation of cell fate specification (GO:0009996)	2.04954116
67	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	2.02137505
68	ephrin receptor signaling pathway (GO:0048013)	2.00018010
69	keratinization (GO:0031424)	12.3517591
70	intermediate filament organization (GO:0045109)	12.0012200
71	desmosome organization (GO:0002934)	10.4421670
72	craniofacial suture morphogenesis (GO:0097094)	1.98543586
73	non-canonical Wnt signaling pathway (GO:0035567)	1.96378851
74	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.93967000
75	negative regulation of epidermal cell differentiation (GO:0045605)	1.92390155
76	outflow tract septum morphogenesis (GO:0003148)	1.90916804
77	aging (GO:0007568)	1.89897333
78	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.89621037
79	regulation of keratinocyte proliferation (GO:0010837)	1.88925506
80	regulation of heart rate by cardiac conduction (GO:0086091)	1.88426037
81	epithelial cell-cell adhesion (GO:0090136)	1.86508884
82	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.86489022
83	cell communication involved in cardiac conduction (GO:0086065)	1.86109722
84	chondrocyte development (GO:0002063)	1.85968529
85	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.80121398
86	positive regulation of meiosis (GO:0045836)	1.79770589
87	wound healing, spreading of cells (GO:0044319)	1.78785523
88	establishment of planar polarity (GO:0001736)	1.78722258
89	establishment of tissue polarity (GO:0007164)	1.78722258
90	very long-chain fatty acid metabolic process (GO:0000038)	1.76419998
91	regulation of cardioblast differentiation (GO:0051890)	1.76018560
92	lateral sprouting from an epithelium (GO:0060601)	1.76008205
93	regulation of monocyte chemotaxis (GO:0090025)	1.75380888
94	cellular zinc ion homeostasis (GO:0006882)	1.74638027
95	myotube differentiation (GO:0014902)	1.72724938
96	lymph vessel development (GO:0001945)	1.71042030
97	eyelid development in camera-type eye (GO:0061029)	1.69693073
98	cell-substrate junction assembly (GO:0007044)	1.68769067
99	cardiac epithelial to mesenchymal transition (GO:0060317)	1.68171155
100	negative regulation of neurotransmitter secretion (GO:0046929)	1.67419384

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.12549705
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.30893879
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.71900310
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.13540321
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.25894628
6	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.6029302
7	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.98300987
8	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.82587788
9	TAF2_19829295_ChIP-Seq_ESCs_Human	1.77888944
10	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.76764595
11	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.76299232
12	ERG_20517297_ChIP-Seq_VCAP_Human	1.73474461
13	E2F1_20622854_ChIP-Seq_HELA_Human	1.73264272
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.70161661
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.69142257
16	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.67574614
17	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.67310874
18	EGR1_19032775_ChIP-ChIP_M12_Human	1.66645014
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.65204156
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.62434095
21	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.58225020
22	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.57339217
23	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.57339217
24	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.52119488
25	CTCF_27219007_Chip-Seq_Bcells_Human	1.50580869
26	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.49332436
27	AHR_22903824_ChIP-Seq_MCF-7_Human	1.45373862
28	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.44812651
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.44550813
30	TP63_22573176_ChIP-Seq_HFKS_Human	1.44450872
31	RACK7_27058665_Chip-Seq_MCF-7_Human	1.42285374
32	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.41765477
33	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.41359713
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.39539789
35	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.39297345
36	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.38181091
37	BCOR_27268052_Chip-Seq_Bcells_Human	1.37927388
38	TP53_18474530_ChIP-ChIP_U2OS_Human	1.37757914
39	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.37330988
40	TP63_23658742_ChIP-Seq_EP156T_Human	1.30767299
41	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28617488
42	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.27086078
43	CEBPB_22108803_ChIP-Seq_LS180_Human	1.25557603
44	LXR_22292898_ChIP-Seq_THP-1_Human	1.23941333
45	ATF3_27146783_Chip-Seq_COLON_Human	1.22801460
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.20399990
47	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.17850017
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16817390
49	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.15333895
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13943954
51	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.13383555
52	P68_20966046_ChIP-Seq_HELA_Human	1.12981982
53	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.12860745
54	PHF8_20622854_ChIP-Seq_HELA_Human	1.12500829
55	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.10515684
56	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07629075
57	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.05932434
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.03491794
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03140700
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.02704971
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02043807
62	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.00914067
63	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00567873
64	SOX2_21211035_ChIP-Seq_LN229_Human	0.99338010
65	RXR_22108803_ChIP-Seq_LS180_Human	0.99318593
66	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98553666
67	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.98439124
68	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.98299939
69	RAC3_21632823_ChIP-Seq_H3396_Human	0.98218741
70	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.97691672
71	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97276252
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96970143
73	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95425590
74	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.95280926
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94980668
76	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94688823
77	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.94135514
78	SPI1_20517297_ChIP-Seq_HL60_Human	0.93834076
79	* E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.93469242
80	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.92631667
81	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92556139
82	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.92109620
83	SOX2_20726797_ChIP-Seq_SW620_Human	0.90261744
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.90169817
85	SMC4_20622854_ChIP-Seq_HELA_Human	0.90034128
86	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.89025579
87	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88597628
88	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.88405431
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86558368
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86558368
91	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.84776578
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.83931922
93	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.82557848
94	CLOCK_20551151_ChIP-Seq_293T_Human	0.81635909
95	ZNF263_19887448_ChIP-Seq_K562_Human	0.81616653
96	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.80985011
97	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.79991456
98	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.78593404
99	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.76020107
100	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.75653611

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.52825961
2	MP0002098_abnormal_vibrissa_morphology	7.05528586
3	MP0000647_abnormal_sebaceous_gland	6.20328179
4	MP0002796_impaired_skin_barrier	5.71385072
5	MP0005275_abnormal_skin_tensile	5.32439395
6	MP0000383_abnormal_hair_follicle	5.19419767
7	MP0010234_abnormal_vibrissa_follicle	4.85514691
8	MP0010678_abnormal_skin_adnexa	4.55164713
9	MP0000377_abnormal_hair_follicle	4.01266874
10	MP0000427_abnormal_hair_cycle	3.68096028
11	MP0005501_abnormal_skin_physiology	3.47991358
12	MP0002254_reproductive_system_inflammat	3.39329495
13	MP0003705_abnormal_hypodermis_morpholog	3.33927569
14	MP0001216_abnormal_epidermal_layer	2.62137956
15	MP0010771_integument_phenotype	2.33721415
16	MP0004947_skin_inflammation	2.33660523
17	MP0000367_abnormal_coat/_hair	2.33045309
18	MP0004381_abnormal_hair_follicle	2.22931124
19	MP0002060_abnormal_skin_morphology	2.16695410
20	MP0001243_abnormal_dermal_layer	2.14140312
21	MP0003453_abnormal_keratinocyte_physiol	2.10264560
22	MP0002234_abnormal_pharynx_morphology	1.57753698
23	MP0009931_abnormal_skin_appearance	1.50938918
24	MP0000467_abnormal_esophagus_morphology	1.50448963
25	MP0003941_abnormal_skin_development	1.48196385
26	MP0009053_abnormal_anal_canal	1.42403647
27	MP0000762_abnormal_tongue_morphology	1.40022711
28	MP0003566_abnormal_cell_adhesion	1.37126375
29	MP0001661_extended_life_span	1.24885031
30	MP0005409_darkened_coat_color	1.24586404
31	MP0002095_abnormal_skin_pigmentation	1.12891628
32	MP0004885_abnormal_endolymph	1.08715465
33	MP0009379_abnormal_foot_pigmentation	1.07542389
34	MP0008438_abnormal_cutaneous_collagen	1.00664254
35	MP0001191_abnormal_skin_condition	1.00235717
36	MP0004185_abnormal_adipocyte_glucose	1.00116633
37	MP0004264_abnormal_extraembryonic_tissu	0.99633412
38	MP0000566_synostosis	0.83885478
39	MP0001346_abnormal_lacrimal_gland	0.80106746
40	MP0002877_abnormal_melanocyte_morpholog	0.71456737
41	MP0001340_abnormal_eyelid_morphology	0.69800543
42	MP0010030_abnormal_orbit_morphology	0.62664441
43	MP0001851_eye_inflammation	0.60770195
44	MP0003315_abnormal_perineum_morphology	0.55739805
45	MP0002009_preneoplasia	0.55062969
46	MP0000627_abnormal_mammary_gland	0.55042722
47	MP0003191_abnormal_cellular_cholesterol	0.51709634
48	MP0001849_ear_inflammation	0.46051598
49	MP0002282_abnormal_trachea_morphology	0.45283561
50	MP0001784_abnormal_fluid_regulation	0.45173820
51	MP0002970_abnormal_white_adipose	0.44080073
52	MP0003755_abnormal_palate_morphology	0.43963401
53	MP0005023_abnormal_wound_healing	0.42725228
54	MP0010352_gastrointestinal_tract_polyps	0.40689307
55	MP0002111_abnormal_tail_morphology	0.39403133
56	MP0002177_abnormal_outer_ear	0.37433773
57	MP0009384_cardiac_valve_regurgitation	0.36476956
58	MP0002166_altered_tumor_susceptibility	0.36425679
59	MP0004272_abnormal_basement_membrane	0.34463312
60	MP0005451_abnormal_body_composition	0.33972801
61	MP0003385_abnormal_body_wall	0.33495199
62	MP0000537_abnormal_urethra_morphology	0.33431227
63	MP0002006_tumorigenesis	0.33136334
64	MP0002697_abnormal_eye_size	0.30817000
65	MP0005248_abnormal_Harderian_gland	0.27947281
66	MP0000432_abnormal_head_morphology	0.25954270
67	MP0003950_abnormal_plasma_membrane	0.24461813
68	MP0005075_abnormal_melanosome_morpholog	0.22145583
69	MP0003329_amyloid_beta_deposits	0.19903295
70	MP0003300_gastrointestinal_ulcer	0.18849744
71	MP0005666_abnormal_adipose_tissue	0.18753175
72	MP0006054_spinal_hemorrhage	0.17929435
73	MP0003935_abnormal_craniofacial_develop	0.17450378
74	MP0002249_abnormal_larynx_morphology	0.16338727
75	MP0009840_abnormal_foam_cell	0.15881318
76	MP0003763_abnormal_thymus_physiology	0.13663238
77	MP0005257_abnormal_intraocular_pressure	0.13260211
78	MP0000604_amyloidosis	0.13020446
79	MP0000465_gastrointestinal_hemorrhage	0.12948105
80	MP0003638_abnormal_response/metabolism_	0.12044999
81	MP0001730_embryonic_growth_arrest	0.11326524
82	MP0005076_abnormal_cell_differentiation	0.11173595
83	MP0001958_emphysema	0.10890030
84	MP0005375_adipose_tissue_phenotype	0.10419583
85	MP0005367_renal/urinary_system_phenotyp	0.10382722
86	MP0000516_abnormal_urinary_system	0.10382722
87	MP0005193_abnormal_anterior_eye	0.09787401
88	MP0005503_abnormal_tendon_morphology	0.09717357
89	MP0005508_abnormal_skeleton_morphology	0.08147128
90	MP0002896_abnormal_bone_mineralization	0.07598991
91	MP0000013_abnormal_adipose_tissue	0.07474725
92	MP0003448_altered_tumor_morphology	0.07439496
93	MP0000538_abnormal_urinary_bladder	0.07314819
94	MP0000428_abnormal_craniofacial_morphol	0.07263298
95	MP0003937_abnormal_limbs/digits/tail_de	0.07082224
96	MP0004742_abnormal_vestibular_system	0.07021004
97	MP0004019_abnormal_vitamin_homeostasis	0.06677001
98	MP0000751_myopathy	0.06196883
99	MP0003075_altered_response_to	0.05842690
100	MP0002233_abnormal_nose_morphology	0.04511154

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.32155174
2	Nail dystrophy (HP:0008404)	7.31485009
3	Abnormal hair laboratory examination (HP:0003328)	5.90596445
4	Fine hair (HP:0002213)	5.57172853
5	Abnormality of nail color (HP:0100643)	5.38193901
6	Fragile nails (HP:0001808)	5.26681864
7	Follicular hyperkeratosis (HP:0007502)	5.06205425
8	Alopecia of scalp (HP:0002293)	4.70034856
9	Palmoplantar hyperkeratosis (HP:0000972)	4.30424764
10	Palmar hyperkeratosis (HP:0010765)	4.05317744
11	Plantar hyperkeratosis (HP:0007556)	3.91429395
12	Right ventricular cardiomyopathy (HP:0011663)	3.75742883
13	Sparse eyelashes (HP:0000653)	3.73878181
14	Onycholysis (HP:0001806)	3.66640846
15	Parakeratosis (HP:0001036)	3.65150849
16	Thick nail (HP:0001805)	3.62065513
17	Congenital, generalized hypertrichosis (HP:0004540)	3.49802588
18	Erythema (HP:0010783)	3.33626548
19	Abnormality of the frontal sinuses (HP:0002687)	3.31598779
20	Increased IgE level (HP:0003212)	3.17280993
21	Amelogenesis imperfecta (HP:0000705)	2.98059218
22	Oral leukoplakia (HP:0002745)	2.91244110
23	Erythroderma (HP:0001019)	2.78770252
24	Milia (HP:0001056)	2.77652521
25	Congenital ichthyosiform erythroderma (HP:0007431)	2.74510600
26	Intention tremor (HP:0002080)	2.63468069
27	Curly hair (HP:0002212)	2.59930247
28	Dry hair (HP:0011359)	2.52205535
29	Aplasia cutis congenita (HP:0001057)	2.51851858
30	Neck muscle weakness (HP:0000467)	2.36483359
31	Torticollis (HP:0000473)	2.36442494
32	Ridged nail (HP:0001807)	2.35907027
33	Corneal erosion (HP:0200020)	2.13533256
34	Concave nail (HP:0001598)	2.11459460
35	Natal tooth (HP:0000695)	2.05267312
36	Hypohidrosis (HP:0000966)	2.03280203
37	Abnormal blistering of the skin (HP:0008066)	2.00815440
38	Hypotrichosis (HP:0001006)	14.8149229
39	Abnormality of hair growth rate (HP:0011363)	11.7322164
40	Slow-growing hair (HP:0002217)	11.7322164
41	Woolly hair (HP:0002224)	11.1898380
42	Brittle hair (HP:0002299)	10.9929343
43	Craniofacial dystonia (HP:0012179)	1.99488212
44	Abnormality of the parietal bone (HP:0002696)	1.96591169
45	Advanced eruption of teeth (HP:0006288)	1.95962231
46	Pruritus (HP:0000989)	1.92939797
47	Palmoplantar keratoderma (HP:0000982)	1.92263870
48	Absent eyelashes (HP:0000561)	1.88614292
49	Abnormality of the pupil (HP:0000615)	1.84777219
50	Focal dystonia (HP:0004373)	1.82912985
51	Widely patent fontanelles and sutures (HP:0004492)	1.81616335
52	Abnormality of the dental root (HP:0006486)	1.81221001
53	Taurodontia (HP:0000679)	1.81221001
54	Abnormality of permanent molar morphology (HP:0011071)	1.81221001
55	Abnormality of molar morphology (HP:0011070)	1.78349362
56	Abnormality of molar (HP:0011077)	1.78349362
57	Abnormality of dental color (HP:0011073)	1.77778043
58	Hyporeflexia of lower limbs (HP:0002600)	1.76889028
59	Ventricular tachycardia (HP:0004756)	1.76612866
60	Difficulty walking (HP:0002355)	1.72871310
61	Recurrent corneal erosions (HP:0000495)	1.69968435
62	Ventricular fibrillation (HP:0001663)	1.61051553
63	Conjunctival hamartoma (HP:0100780)	1.58850171
64	Abnormality of the dental pulp (HP:0006479)	1.58105518
65	Amniotic constriction ring (HP:0009775)	1.57997475
66	Abnormality of placental membranes (HP:0011409)	1.57997475
67	Lip pit (HP:0100267)	1.56050161
68	Blepharitis (HP:0000498)	1.52505400
69	Keratoconjunctivitis sicca (HP:0001097)	1.46249199
70	Acanthosis nigricans (HP:0000956)	1.45365806
71	Craniofacial hyperostosis (HP:0004493)	1.44146183
72	Autoamputation (HP:0001218)	1.41312436
73	Heterogeneous (HP:0001425)	1.37252270
74	Achilles tendon contracture (HP:0001771)	1.34337611
75	Distal lower limb muscle weakness (HP:0009053)	1.31575393
76	Round ear (HP:0100830)	1.29782876
77	Ectropion (HP:0000656)	1.29198415
78	Gangrene (HP:0100758)	1.29035079
79	Widely spaced teeth (HP:0000687)	1.28605677
80	Keratoconjunctivitis (HP:0001096)	1.28211103
81	Abnormality of the Achilles tendon (HP:0005109)	1.27964017
82	Carious teeth (HP:0000670)	1.26494180
83	Sudden death (HP:0001699)	1.25628412
84	Atrophic scars (HP:0001075)	1.25012975
85	Lack of skin elasticity (HP:0100679)	1.23746029
86	Fatigable weakness (HP:0003473)	1.20861227
87	Abnormality of the neuromuscular junction (HP:0003398)	1.20861227
88	Rectal prolapse (HP:0002035)	1.17982787
89	Variable expressivity (HP:0003828)	1.17592596
90	Wide cranial sutures (HP:0010537)	1.16891843
91	Abnormality of the fingernails (HP:0001231)	1.16365037
92	Increased connective tissue (HP:0009025)	1.15479441
93	Hypoplastic labia majora (HP:0000059)	1.14303886
94	Sparse scalp hair (HP:0002209)	1.13105732
95	Type 1 muscle fiber predominance (HP:0003803)	1.11779691
96	Bronchomalacia (HP:0002780)	1.08888004
97	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.08251370
98	Selective tooth agenesis (HP:0001592)	1.07623303
99	Anonychia (HP:0001798)	1.06661796
100	Cranial hyperostosis (HP:0004437)	1.05652218

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.21303912
2	MAPKAPK3	3.77516423
3	FER	3.35783760
4	ERN1	3.34450402
5	LATS1	3.24383582
6	EPHB2	3.09685083
7	MAP3K6	2.96040511
8	MAP3K2	2.85390655
9	FGFR2	2.78234408
10	MAP3K3	2.69468883
11	TAOK1	2.56268470
12	TRIB3	2.20741300
13	RPS6KB2	1.96330821
14	TTN	1.87321819
15	MAP2K6	1.86630304
16	BCR	1.75944962
17	LATS2	1.75368242
18	FGFR1	1.71825030
19	MAP3K11	1.70564999
20	PIK3CG	1.65629659
21	FGFR3	1.55466139
22	MST1R	1.44841871
23	CDK6	1.42160915
24	KSR2	1.35671021
25	PBK	1.31338572
26	NME1	1.27986953
27	EPHB1	1.26469568
28	EEF2K	1.24113503
29	PDGFRA	1.18507122
30	MAP3K1	1.17076214
31	PTK6	1.16424609
32	RIPK1	1.13800225
33	LRRK2	1.06962638
34	MAP3K7	1.06566205
35	MAP3K9	1.02154313
36	MAP2K4	1.01732431
37	MAP2K3	1.00581532
38	BMX	0.97635175
39	ERBB4	0.97460361
40	PKN2	0.93461742
41	MAPKAPK2	0.92725846
42	ERBB3	0.89881798
43	MET	0.84426583
44	FGFR4	0.80439233
45	MAP2K1	0.80267743
46	PAK3	0.75994388
47	SIK1	0.74371191
48	NEK1	0.73512936
49	STK38	0.73254102
50	FRK	0.73253541
51	DYRK1B	0.72730223
52	TRPM7	0.71980827
53	DDR2	0.70182485
54	NTRK2	0.70169340
55	BLK	0.69015784
56	CDK19	0.67916355
57	PRKD1	0.66914597
58	MST4	0.65787598
59	PTK2	0.65368001
60	RPS6KA4	0.63946924
61	TGFBR1	0.63823012
62	STK38L	0.59872479
63	ERBB2	0.58538655
64	TYRO3	0.57652652
65	MAP3K5	0.57333600
66	TESK1	0.56849045
67	PRKCH	0.56502684
68	PIM2	0.54393655
69	CSNK1A1L	0.53441245
70	PAK4	0.52734636
71	CSNK1E	0.51533290
72	RET	0.50787352
73	SCYL2	0.50137971
74	ALK	0.47347678
75	GSK3A	0.46806839
76	CSNK1G1	0.42975994
77	STK3	0.41745626
78	PAK6	0.40670019
79	EPHA4	0.40260759
80	LIMK1	0.39699454
81	CSNK1G3	0.38432203
82	JAK2	0.37751090
83	MAPK12	0.37230363
84	PRKCI	0.35484000
85	MARK3	0.34028710
86	PAK2	0.33781012
87	RPS6KA1	0.32955210
88	MINK1	0.32699532
89	ILK	0.32228364
90	CSNK1D	0.31035813
91	FYN	0.29678940
92	CSNK1G2	0.29623940
93	ROCK2	0.29597644
94	KSR1	0.29468301
95	PDPK1	0.28573283
96	SRC	0.28562400
97	MAP3K10	0.28299459
98	JAK1	0.27324695
99	MAP2K2	0.26414452
100	PRKACG	0.25988512

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	4.25585755
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.25530275
3	Fat digestion and absorption_Homo sapiens_hsa04975	2.65927452
4	Fatty acid elongation_Homo sapiens_hsa00062	2.43156418
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.32846279
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.26758753
7	Melanogenesis_Homo sapiens_hsa04916	1.74544605
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.71988773
9	VEGF signaling pathway_Homo sapiens_hsa04370	1.68121489
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.67090628
11	Axon guidance_Homo sapiens_hsa04360	1.60330639
12	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.56653860
13	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.55783161
14	Bladder cancer_Homo sapiens_hsa05219	1.51903990
15	Glioma_Homo sapiens_hsa05214	1.48580584
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.46819763
17	Hippo signaling pathway_Homo sapiens_hsa04390	1.46311346
18	Thyroid cancer_Homo sapiens_hsa05216	1.43459070
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.43227796
20	Histidine metabolism_Homo sapiens_hsa00340	1.39543710
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.38820316
22	Long-term potentiation_Homo sapiens_hsa04720	1.37676585
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.28638118
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.28309377
25	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.27843090
26	Mineral absorption_Homo sapiens_hsa04978	1.26666635
27	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.25722620
28	Tight junction_Homo sapiens_hsa04530	1.18519272
29	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.08803603
30	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.06626286
31	PPAR signaling pathway_Homo sapiens_hsa03320	1.04221311
32	Tyrosine metabolism_Homo sapiens_hsa00350	1.01942871
33	Long-term depression_Homo sapiens_hsa04730	1.01204820
34	Adherens junction_Homo sapiens_hsa04520	1.00196787
35	Pancreatic secretion_Homo sapiens_hsa04972	0.99392725
36	Endometrial cancer_Homo sapiens_hsa05213	0.98948203
37	Non-small cell lung cancer_Homo sapiens_hsa05223	0.97077497
38	ECM-receptor interaction_Homo sapiens_hsa04512	0.95506262
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93856993
40	Caffeine metabolism_Homo sapiens_hsa00232	0.93223469
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91330306
42	Wnt signaling pathway_Homo sapiens_hsa04310	0.89532180
43	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.86743982
44	Acute myeloid leukemia_Homo sapiens_hsa05221	0.84394551
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83151523
46	Ras signaling pathway_Homo sapiens_hsa04014	0.81795099
47	Pertussis_Homo sapiens_hsa05133	0.81186855
48	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80913464
49	MicroRNAs in cancer_Homo sapiens_hsa05206	0.79335061
50	Renin secretion_Homo sapiens_hsa04924	0.78662163
51	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77842894
52	Butanoate metabolism_Homo sapiens_hsa00650	0.74474892
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72583354
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.72110040
55	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71075963
56	Amoebiasis_Homo sapiens_hsa05146	0.70416834
57	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.70378282
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.69992091
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.68015586
60	Gastric acid secretion_Homo sapiens_hsa04971	0.67917478
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.67895045
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67865362
63	Gap junction_Homo sapiens_hsa04540	0.65706408
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.64692285
65	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.61025592
66	Insulin resistance_Homo sapiens_hsa04931	0.60891577
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.60356810
68	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60324490
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58501691
70	Focal adhesion_Homo sapiens_hsa04510	0.58410028
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.58215149
72	Hepatitis C_Homo sapiens_hsa05160	0.57988134
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57602506
74	Platelet activation_Homo sapiens_hsa04611	0.57195784
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.56359616
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.56288905
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56169629
78	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.56101281
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55810430
80	Fatty acid degradation_Homo sapiens_hsa00071	0.55721740
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.54350655
82	p53 signaling pathway_Homo sapiens_hsa04115	0.53018651
83	Salivary secretion_Homo sapiens_hsa04970	0.48187905
84	Salmonella infection_Homo sapiens_hsa05132	0.48151759
85	Arginine biosynthesis_Homo sapiens_hsa00220	0.47761929
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47531723
87	Melanoma_Homo sapiens_hsa05218	0.46817209
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45653823
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45296136
90	Phototransduction_Homo sapiens_hsa04744	0.44672414
91	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44590341
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.44060595
93	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.42994241
94	Complement and coagulation cascades_Homo sapiens_hsa04610	0.42875128
95	Prion diseases_Homo sapiens_hsa05020	0.41715494
96	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.41638409
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37219077
98	Amphetamine addiction_Homo sapiens_hsa05031	0.35078265
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.34862934
100	Prostate cancer_Homo sapiens_hsa05215	0.34055542

KRTAP19-4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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