KRTAP19-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.73375160
2virion attachment to host cell (GO:0019062)9.73375160
3peptide cross-linking (GO:0018149)8.69028591
4hair follicle morphogenesis (GO:0031069)8.43406351
5citrulline biosynthetic process (GO:0019240)8.22040090
6adhesion of symbiont to host (GO:0044406)8.15619364
7intermediate filament cytoskeleton organization (GO:0045104)6.79084119
8cell wall macromolecule catabolic process (GO:0016998)6.64540872
9cell wall macromolecule metabolic process (GO:0044036)6.64540872
10intermediate filament-based process (GO:0045103)6.56839742
11epidermis development (GO:0008544)6.47281620
12establishment of skin barrier (GO:0061436)6.34718421
13keratinocyte differentiation (GO:0030216)6.06729599
14hair cycle process (GO:0022405)5.72996596
15molting cycle process (GO:0022404)5.72996596
16regulation of water loss via skin (GO:0033561)5.62527120
17citrulline metabolic process (GO:0000052)5.43724234
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.87006421
19epidermal cell differentiation (GO:0009913)4.73816258
20hemidesmosome assembly (GO:0031581)4.65835731
21peptidyl-arginine modification (GO:0018195)4.52463358
22skin morphogenesis (GO:0043589)4.11358297
23hair cycle (GO:0042633)32.7194516
24molting cycle (GO:0042303)32.7194516
25keratinocyte development (GO:0003334)3.84893166
26tooth mineralization (GO:0034505)3.84428829
27multicellular organismal water homeostasis (GO:0050891)3.75399212
28hair follicle development (GO:0001942)3.74699873
29regulation of keratinocyte differentiation (GO:0045616)3.71339436
30bone trabecula formation (GO:0060346)3.53827287
31positive regulation of hair follicle development (GO:0051798)3.36548567
32positive regulation of hair cycle (GO:0042635)3.36548567
33negative regulation of keratinocyte proliferation (GO:0010839)3.36412923
34phosphatidylinositol acyl-chain remodeling (GO:0036149)3.31281595
35gap junction assembly (GO:0016264)3.20598439
36positive regulation of meiotic cell cycle (GO:0051446)3.17684178
37negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.12228662
38regulation of hair follicle development (GO:0051797)3.12123526
39epithelium development (GO:0060429)3.08379432
40water homeostasis (GO:0030104)3.07336663
41regulation of hair cycle (GO:0042634)2.99641676
42phosphatidylserine acyl-chain remodeling (GO:0036150)2.97594948
43epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.89802181
44phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.78286881
45regulation of epidermal cell differentiation (GO:0045604)2.77849996
46cranial suture morphogenesis (GO:0060363)2.76871154
47positive regulation of epidermis development (GO:0045684)2.65887761
48wound healing, spreading of epidermal cells (GO:0035313)2.59731916
49negative regulation of protein localization to plasma membrane (GO:1903077)2.59684105
50regulation of epidermis development (GO:0045682)2.58389583
51ectoderm development (GO:0007398)2.54925928
52cell surface receptor signaling pathway involved in heart development (GO:0061311)2.49894564
53fatty acid elongation (GO:0030497)2.49114165
54positive regulation of monocyte chemotaxis (GO:0090026)2.46883285
55atrioventricular valve morphogenesis (GO:0003181)2.25538620
56phosphatidylserine metabolic process (GO:0006658)2.24702355
57negative regulation of epidermis development (GO:0045683)2.24321447
58keratinocyte proliferation (GO:0043616)2.23955857
59ventricular cardiac muscle cell action potential (GO:0086005)2.22603463
60phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.20638997
61regulation of ruffle assembly (GO:1900027)2.19183966
62positive regulation of epidermal cell differentiation (GO:0045606)2.14437135
63regulation of mesenchymal cell apoptotic process (GO:2001053)2.11713364
64skin development (GO:0043588)2.08274530
65planar cell polarity pathway involved in neural tube closure (GO:0090179)2.06242800
66negative regulation of cell fate specification (GO:0009996)2.04954116
67regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.02137505
68ephrin receptor signaling pathway (GO:0048013)2.00018010
69keratinization (GO:0031424)12.3517591
70intermediate filament organization (GO:0045109)12.0012200
71desmosome organization (GO:0002934)10.4421670
72craniofacial suture morphogenesis (GO:0097094)1.98543586
73non-canonical Wnt signaling pathway (GO:0035567)1.96378851
74phosphatidylcholine acyl-chain remodeling (GO:0036151)1.93967000
75negative regulation of epidermal cell differentiation (GO:0045605)1.92390155
76outflow tract septum morphogenesis (GO:0003148)1.90916804
77aging (GO:0007568)1.89897333
78regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.89621037
79regulation of keratinocyte proliferation (GO:0010837)1.88925506
80regulation of heart rate by cardiac conduction (GO:0086091)1.88426037
81epithelial cell-cell adhesion (GO:0090136)1.86508884
82cytoskeletal anchoring at plasma membrane (GO:0007016)1.86489022
83cell communication involved in cardiac conduction (GO:0086065)1.86109722
84chondrocyte development (GO:0002063)1.85968529
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.80121398
86positive regulation of meiosis (GO:0045836)1.79770589
87wound healing, spreading of cells (GO:0044319)1.78785523
88establishment of tissue polarity (GO:0007164)1.78722258
89establishment of planar polarity (GO:0001736)1.78722258
90very long-chain fatty acid metabolic process (GO:0000038)1.76419998
91regulation of cardioblast differentiation (GO:0051890)1.76018560
92lateral sprouting from an epithelium (GO:0060601)1.76008205
93regulation of monocyte chemotaxis (GO:0090025)1.75380888
94cellular zinc ion homeostasis (GO:0006882)1.74638027
95myotube differentiation (GO:0014902)1.72724938
96lymph vessel development (GO:0001945)1.71042030
97eyelid development in camera-type eye (GO:0061029)1.69693073
98cell-substrate junction assembly (GO:0007044)1.68769067
99cardiac epithelial to mesenchymal transition (GO:0060317)1.68171155
100negative regulation of neurotransmitter secretion (GO:0046929)1.67419384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.12549705
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.30893879
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.71900310
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13540321
5CTCF_20526341_ChIP-Seq_ESCs_Human2.25894628
6TP63_17297297_ChIP-ChIP_HaCaT_Human12.6029302
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.98300987
8NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.82587788
9TAF2_19829295_ChIP-Seq_ESCs_Human1.77888944
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76764595
11SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76299232
12ERG_20517297_ChIP-Seq_VCAP_Human1.73474461
13E2F1_20622854_ChIP-Seq_HELA_Human1.73264272
14VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.70161661
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.69142257
16CSB_26484114_Chip-Seq_FIBROBLAST_Human1.67574614
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.67310874
18EGR1_19032775_ChIP-ChIP_M12_Human1.66645014
19P53_21459846_ChIP-Seq_SAOS-2_Human1.65204156
20NANOG_20526341_ChIP-Seq_ESCs_Human1.62434095
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.58225020
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57339217
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57339217
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.52119488
25CTCF_27219007_Chip-Seq_Bcells_Human1.50580869
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.49332436
27AHR_22903824_ChIP-Seq_MCF-7_Human1.45373862
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.44812651
29BCL6_27268052_Chip-Seq_Bcells_Human1.44550813
30TP63_22573176_ChIP-Seq_HFKS_Human1.44450872
31RACK7_27058665_Chip-Seq_MCF-7_Human1.42285374
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41765477
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.41359713
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39539789
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39297345
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38181091
37BCOR_27268052_Chip-Seq_Bcells_Human1.37927388
38TP53_18474530_ChIP-ChIP_U2OS_Human1.37757914
39MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.37330988
40TP63_23658742_ChIP-Seq_EP156T_Human1.30767299
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.28617488
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27086078
43CEBPB_22108803_ChIP-Seq_LS180_Human1.25557603
44LXR_22292898_ChIP-Seq_THP-1_Human1.23941333
45ATF3_27146783_Chip-Seq_COLON_Human1.22801460
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20399990
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17850017
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.16817390
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15333895
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13943954
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.13383555
52P68_20966046_ChIP-Seq_HELA_Human1.12981982
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12860745
54PHF8_20622854_ChIP-Seq_HELA_Human1.12500829
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.10515684
56GATA4_25053715_ChIP-Seq_YYC3_Human1.07629075
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05932434
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.03491794
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03140700
60AR_21572438_ChIP-Seq_LNCaP_Human1.02704971
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02043807
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00914067
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00567873
64SOX2_21211035_ChIP-Seq_LN229_Human0.99338010
65RXR_22108803_ChIP-Seq_LS180_Human0.99318593
66KLF5_25053715_ChIP-Seq_YYC3_Human0.98553666
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98439124
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98299939
69RAC3_21632823_ChIP-Seq_H3396_Human0.98218741
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97691672
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97276252
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96970143
73GATA6_21074721_ChIP-Seq_CACO-2_Human0.95425590
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95280926
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.94980668
76GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94688823
77IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94135514
78SPI1_20517297_ChIP-Seq_HL60_Human0.93834076
79* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.93469242
80SA1_27219007_Chip-Seq_ERYTHROID_Human0.92631667
81RING1B_27294783_Chip-Seq_ESCs_Mouse0.92556139
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92109620
83SOX2_20726797_ChIP-Seq_SW620_Human0.90261744
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90169817
85SMC4_20622854_ChIP-Seq_HELA_Human0.90034128
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89025579
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88597628
88RUNX1_27514584_Chip-Seq_MCF-7_Human0.88405431
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86558368
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.86558368
91RNF2_27304074_Chip-Seq_ESCs_Mouse0.84776578
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83931922
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.82557848
94CLOCK_20551151_ChIP-Seq_293T_Human0.81635909
95ZNF263_19887448_ChIP-Seq_K562_Human0.81616653
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80985011
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.79991456
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.78593404
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.76020107
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75653611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.52825961
2MP0002098_abnormal_vibrissa_morphology7.05528586
3MP0000647_abnormal_sebaceous_gland6.20328179
4MP0002796_impaired_skin_barrier5.71385072
5MP0005275_abnormal_skin_tensile5.32439395
6MP0000383_abnormal_hair_follicle5.19419767
7MP0010234_abnormal_vibrissa_follicle4.85514691
8MP0010678_abnormal_skin_adnexa4.55164713
9MP0000377_abnormal_hair_follicle4.01266874
10MP0000427_abnormal_hair_cycle3.68096028
11MP0005501_abnormal_skin_physiology3.47991358
12MP0002254_reproductive_system_inflammat3.39329495
13MP0003705_abnormal_hypodermis_morpholog3.33927569
14MP0001216_abnormal_epidermal_layer2.62137956
15MP0010771_integument_phenotype2.33721415
16MP0004947_skin_inflammation2.33660523
17MP0000367_abnormal_coat/_hair2.33045309
18MP0004381_abnormal_hair_follicle2.22931124
19MP0002060_abnormal_skin_morphology2.16695410
20MP0001243_abnormal_dermal_layer2.14140312
21MP0003453_abnormal_keratinocyte_physiol2.10264560
22MP0002234_abnormal_pharynx_morphology1.57753698
23MP0009931_abnormal_skin_appearance1.50938918
24MP0000467_abnormal_esophagus_morphology1.50448963
25MP0003941_abnormal_skin_development1.48196385
26MP0009053_abnormal_anal_canal1.42403647
27MP0000762_abnormal_tongue_morphology1.40022711
28MP0003566_abnormal_cell_adhesion1.37126375
29MP0001661_extended_life_span1.24885031
30MP0005409_darkened_coat_color1.24586404
31MP0002095_abnormal_skin_pigmentation1.12891628
32MP0004885_abnormal_endolymph1.08715465
33MP0009379_abnormal_foot_pigmentation1.07542389
34MP0008438_abnormal_cutaneous_collagen1.00664254
35MP0001191_abnormal_skin_condition1.00235717
36MP0004185_abnormal_adipocyte_glucose1.00116633
37MP0004264_abnormal_extraembryonic_tissu0.99633412
38MP0000566_synostosis0.83885478
39MP0001346_abnormal_lacrimal_gland0.80106746
40MP0002877_abnormal_melanocyte_morpholog0.71456737
41MP0001340_abnormal_eyelid_morphology0.69800543
42MP0010030_abnormal_orbit_morphology0.62664441
43MP0001851_eye_inflammation0.60770195
44MP0003315_abnormal_perineum_morphology0.55739805
45MP0002009_preneoplasia0.55062969
46MP0000627_abnormal_mammary_gland0.55042722
47MP0003191_abnormal_cellular_cholesterol0.51709634
48MP0001849_ear_inflammation0.46051598
49MP0002282_abnormal_trachea_morphology0.45283561
50MP0001784_abnormal_fluid_regulation0.45173820
51MP0002970_abnormal_white_adipose0.44080073
52MP0003755_abnormal_palate_morphology0.43963401
53MP0005023_abnormal_wound_healing0.42725228
54MP0010352_gastrointestinal_tract_polyps0.40689307
55MP0002111_abnormal_tail_morphology0.39403133
56MP0002177_abnormal_outer_ear0.37433773
57MP0009384_cardiac_valve_regurgitation0.36476956
58MP0002166_altered_tumor_susceptibility0.36425679
59MP0004272_abnormal_basement_membrane0.34463312
60MP0005451_abnormal_body_composition0.33972801
61MP0003385_abnormal_body_wall0.33495199
62MP0000537_abnormal_urethra_morphology0.33431227
63MP0002006_tumorigenesis0.33136334
64MP0002697_abnormal_eye_size0.30817000
65MP0005248_abnormal_Harderian_gland0.27947281
66MP0000432_abnormal_head_morphology0.25954270
67MP0003950_abnormal_plasma_membrane0.24461813
68MP0005075_abnormal_melanosome_morpholog0.22145583
69MP0003329_amyloid_beta_deposits0.19903295
70MP0003300_gastrointestinal_ulcer0.18849744
71MP0005666_abnormal_adipose_tissue0.18753175
72MP0006054_spinal_hemorrhage0.17929435
73MP0003935_abnormal_craniofacial_develop0.17450378
74MP0002249_abnormal_larynx_morphology0.16338727
75MP0009840_abnormal_foam_cell0.15881318
76MP0003763_abnormal_thymus_physiology0.13663238
77MP0005257_abnormal_intraocular_pressure0.13260211
78MP0000604_amyloidosis0.13020446
79MP0000465_gastrointestinal_hemorrhage0.12948105
80MP0003638_abnormal_response/metabolism_0.12044999
81MP0001730_embryonic_growth_arrest0.11326524
82MP0005076_abnormal_cell_differentiation0.11173595
83MP0001958_emphysema0.10890030
84MP0005375_adipose_tissue_phenotype0.10419583
85MP0000516_abnormal_urinary_system0.10382722
86MP0005367_renal/urinary_system_phenotyp0.10382722
87MP0005193_abnormal_anterior_eye0.09787401
88MP0005503_abnormal_tendon_morphology0.09717357
89MP0005508_abnormal_skeleton_morphology0.08147128
90MP0002896_abnormal_bone_mineralization0.07598991
91MP0000013_abnormal_adipose_tissue0.07474725
92MP0003448_altered_tumor_morphology0.07439496
93MP0000538_abnormal_urinary_bladder0.07314819
94MP0000428_abnormal_craniofacial_morphol0.07263298
95MP0003937_abnormal_limbs/digits/tail_de0.07082224
96MP0004742_abnormal_vestibular_system0.07021004
97MP0004019_abnormal_vitamin_homeostasis0.06677001
98MP0000751_myopathy0.06196883
99MP0003075_altered_response_to0.05842690
100MP0002233_abnormal_nose_morphology0.04511154

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.32155174
2Nail dystrophy (HP:0008404)7.31485009
3Abnormal hair laboratory examination (HP:0003328)5.90596445
4Fine hair (HP:0002213)5.57172853
5Abnormality of nail color (HP:0100643)5.38193901
6Fragile nails (HP:0001808)5.26681864
7Follicular hyperkeratosis (HP:0007502)5.06205425
8Alopecia of scalp (HP:0002293)4.70034856
9Palmoplantar hyperkeratosis (HP:0000972)4.30424764
10Palmar hyperkeratosis (HP:0010765)4.05317744
11Plantar hyperkeratosis (HP:0007556)3.91429395
12Right ventricular cardiomyopathy (HP:0011663)3.75742883
13Sparse eyelashes (HP:0000653)3.73878181
14Onycholysis (HP:0001806)3.66640846
15Parakeratosis (HP:0001036)3.65150849
16Thick nail (HP:0001805)3.62065513
17Congenital, generalized hypertrichosis (HP:0004540)3.49802588
18Erythema (HP:0010783)3.33626548
19Abnormality of the frontal sinuses (HP:0002687)3.31598779
20Increased IgE level (HP:0003212)3.17280993
21Amelogenesis imperfecta (HP:0000705)2.98059218
22Oral leukoplakia (HP:0002745)2.91244110
23Erythroderma (HP:0001019)2.78770252
24Milia (HP:0001056)2.77652521
25Congenital ichthyosiform erythroderma (HP:0007431)2.74510600
26Intention tremor (HP:0002080)2.63468069
27Curly hair (HP:0002212)2.59930247
28Dry hair (HP:0011359)2.52205535
29Aplasia cutis congenita (HP:0001057)2.51851858
30Neck muscle weakness (HP:0000467)2.36483359
31Torticollis (HP:0000473)2.36442494
32Ridged nail (HP:0001807)2.35907027
33Corneal erosion (HP:0200020)2.13533256
34Concave nail (HP:0001598)2.11459460
35Natal tooth (HP:0000695)2.05267312
36Hypohidrosis (HP:0000966)2.03280203
37Abnormal blistering of the skin (HP:0008066)2.00815440
38Hypotrichosis (HP:0001006)14.8149229
39Abnormality of hair growth rate (HP:0011363)11.7322164
40Slow-growing hair (HP:0002217)11.7322164
41Woolly hair (HP:0002224)11.1898380
42Brittle hair (HP:0002299)10.9929343
43Craniofacial dystonia (HP:0012179)1.99488212
44Abnormality of the parietal bone (HP:0002696)1.96591169
45Advanced eruption of teeth (HP:0006288)1.95962231
46Pruritus (HP:0000989)1.92939797
47Palmoplantar keratoderma (HP:0000982)1.92263870
48Absent eyelashes (HP:0000561)1.88614292
49Abnormality of the pupil (HP:0000615)1.84777219
50Focal dystonia (HP:0004373)1.82912985
51Widely patent fontanelles and sutures (HP:0004492)1.81616335
52Abnormality of the dental root (HP:0006486)1.81221001
53Taurodontia (HP:0000679)1.81221001
54Abnormality of permanent molar morphology (HP:0011071)1.81221001
55Abnormality of molar morphology (HP:0011070)1.78349362
56Abnormality of molar (HP:0011077)1.78349362
57Abnormality of dental color (HP:0011073)1.77778043
58Hyporeflexia of lower limbs (HP:0002600)1.76889028
59Ventricular tachycardia (HP:0004756)1.76612866
60Difficulty walking (HP:0002355)1.72871310
61Recurrent corneal erosions (HP:0000495)1.69968435
62Ventricular fibrillation (HP:0001663)1.61051553
63Conjunctival hamartoma (HP:0100780)1.58850171
64Abnormality of the dental pulp (HP:0006479)1.58105518
65Amniotic constriction ring (HP:0009775)1.57997475
66Abnormality of placental membranes (HP:0011409)1.57997475
67Lip pit (HP:0100267)1.56050161
68Blepharitis (HP:0000498)1.52505400
69Keratoconjunctivitis sicca (HP:0001097)1.46249199
70Acanthosis nigricans (HP:0000956)1.45365806
71Craniofacial hyperostosis (HP:0004493)1.44146183
72Autoamputation (HP:0001218)1.41312436
73Heterogeneous (HP:0001425)1.37252270
74Achilles tendon contracture (HP:0001771)1.34337611
75Distal lower limb muscle weakness (HP:0009053)1.31575393
76Round ear (HP:0100830)1.29782876
77Ectropion (HP:0000656)1.29198415
78Gangrene (HP:0100758)1.29035079
79Widely spaced teeth (HP:0000687)1.28605677
80Keratoconjunctivitis (HP:0001096)1.28211103
81Abnormality of the Achilles tendon (HP:0005109)1.27964017
82Carious teeth (HP:0000670)1.26494180
83Sudden death (HP:0001699)1.25628412
84Atrophic scars (HP:0001075)1.25012975
85Lack of skin elasticity (HP:0100679)1.23746029
86Fatigable weakness (HP:0003473)1.20861227
87Abnormality of the neuromuscular junction (HP:0003398)1.20861227
88Rectal prolapse (HP:0002035)1.17982787
89Variable expressivity (HP:0003828)1.17592596
90Wide cranial sutures (HP:0010537)1.16891843
91Abnormality of the fingernails (HP:0001231)1.16365037
92Increased connective tissue (HP:0009025)1.15479441
93Hypoplastic labia majora (HP:0000059)1.14303886
94Sparse scalp hair (HP:0002209)1.13105732
95Type 1 muscle fiber predominance (HP:0003803)1.11779691
96Bronchomalacia (HP:0002780)1.08888004
97Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.08251370
98Selective tooth agenesis (HP:0001592)1.07623303
99Anonychia (HP:0001798)1.06661796
100Cranial hyperostosis (HP:0004437)1.05652218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.21303912
2MAPKAPK33.77516423
3FER3.35783760
4ERN13.34450402
5LATS13.24383582
6EPHB23.09685083
7MAP3K62.96040511
8MAP3K22.85390655
9FGFR22.78234408
10MAP3K32.69468883
11TAOK12.56268470
12TRIB32.20741300
13RPS6KB21.96330821
14TTN1.87321819
15MAP2K61.86630304
16BCR1.75944962
17LATS21.75368242
18FGFR11.71825030
19MAP3K111.70564999
20PIK3CG1.65629659
21FGFR31.55466139
22MST1R1.44841871
23CDK61.42160915
24KSR21.35671021
25PBK1.31338572
26NME11.27986953
27EPHB11.26469568
28EEF2K1.24113503
29PDGFRA1.18507122
30MAP3K11.17076214
31PTK61.16424609
32RIPK11.13800225
33LRRK21.06962638
34MAP3K71.06566205
35MAP3K91.02154313
36MAP2K41.01732431
37MAP2K31.00581532
38BMX0.97635175
39ERBB40.97460361
40PKN20.93461742
41MAPKAPK20.92725846
42ERBB30.89881798
43MET0.84426583
44FGFR40.80439233
45MAP2K10.80267743
46PAK30.75994388
47SIK10.74371191
48NEK10.73512936
49STK380.73254102
50FRK0.73253541
51DYRK1B0.72730223
52TRPM70.71980827
53DDR20.70182485
54NTRK20.70169340
55BLK0.69015784
56CDK190.67916355
57PRKD10.66914597
58MST40.65787598
59PTK20.65368001
60RPS6KA40.63946924
61TGFBR10.63823012
62STK38L0.59872479
63ERBB20.58538655
64TYRO30.57652652
65MAP3K50.57333600
66TESK10.56849045
67PRKCH0.56502684
68PIM20.54393655
69CSNK1A1L0.53441245
70PAK40.52734636
71CSNK1E0.51533290
72RET0.50787352
73SCYL20.50137971
74ALK0.47347678
75GSK3A0.46806839
76CSNK1G10.42975994
77STK30.41745626
78PAK60.40670019
79EPHA40.40260759
80LIMK10.39699454
81CSNK1G30.38432203
82JAK20.37751090
83MAPK120.37230363
84PRKCI0.35484000
85MARK30.34028710
86PAK20.33781012
87RPS6KA10.32955210
88MINK10.32699532
89ILK0.32228364
90CSNK1D0.31035813
91FYN0.29678940
92CSNK1G20.29623940
93ROCK20.29597644
94KSR10.29468301
95PDPK10.28573283
96SRC0.28562400
97MAP3K100.28299459
98JAK10.27324695
99MAP2K20.26414452
100PRKACG0.25988512

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.25585755
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.25530275
3Fat digestion and absorption_Homo sapiens_hsa049752.65927452
4Fatty acid elongation_Homo sapiens_hsa000622.43156418
5Ether lipid metabolism_Homo sapiens_hsa005652.32846279
6Basal cell carcinoma_Homo sapiens_hsa052172.26758753
7Melanogenesis_Homo sapiens_hsa049161.74544605
8Phenylalanine metabolism_Homo sapiens_hsa003601.71988773
9VEGF signaling pathway_Homo sapiens_hsa043701.68121489
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.67090628
11Axon guidance_Homo sapiens_hsa043601.60330639
12Arachidonic acid metabolism_Homo sapiens_hsa005901.56653860
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55783161
14Bladder cancer_Homo sapiens_hsa052191.51903990
15Glioma_Homo sapiens_hsa052141.48580584
16Nitrogen metabolism_Homo sapiens_hsa009101.46819763
17Hippo signaling pathway_Homo sapiens_hsa043901.46311346
18Thyroid cancer_Homo sapiens_hsa052161.43459070
19Hedgehog signaling pathway_Homo sapiens_hsa043401.43227796
20Histidine metabolism_Homo sapiens_hsa003401.39543710
21Proteoglycans in cancer_Homo sapiens_hsa052051.38820316
22Long-term potentiation_Homo sapiens_hsa047201.37676585
23GnRH signaling pathway_Homo sapiens_hsa049121.28638118
24Dorso-ventral axis formation_Homo sapiens_hsa043201.28309377
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.27843090
26Mineral absorption_Homo sapiens_hsa049781.26666635
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25722620
28Tight junction_Homo sapiens_hsa045301.18519272
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08803603
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06626286
31PPAR signaling pathway_Homo sapiens_hsa033201.04221311
32Tyrosine metabolism_Homo sapiens_hsa003501.01942871
33Long-term depression_Homo sapiens_hsa047301.01204820
34Adherens junction_Homo sapiens_hsa045201.00196787
35Pancreatic secretion_Homo sapiens_hsa049720.99392725
36Endometrial cancer_Homo sapiens_hsa052130.98948203
37Non-small cell lung cancer_Homo sapiens_hsa052230.97077497
38ECM-receptor interaction_Homo sapiens_hsa045120.95506262
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93856993
40Caffeine metabolism_Homo sapiens_hsa002320.93223469
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91330306
42Wnt signaling pathway_Homo sapiens_hsa043100.89532180
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.86743982
44Acute myeloid leukemia_Homo sapiens_hsa052210.84394551
45Estrogen signaling pathway_Homo sapiens_hsa049150.83151523
46Ras signaling pathway_Homo sapiens_hsa040140.81795099
47Pertussis_Homo sapiens_hsa051330.81186855
48Staphylococcus aureus infection_Homo sapiens_hsa051500.80913464
49MicroRNAs in cancer_Homo sapiens_hsa052060.79335061
50Renin secretion_Homo sapiens_hsa049240.78662163
51TGF-beta signaling pathway_Homo sapiens_hsa043500.77842894
52Butanoate metabolism_Homo sapiens_hsa006500.74474892
53beta-Alanine metabolism_Homo sapiens_hsa004100.72583354
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72110040
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71075963
56Amoebiasis_Homo sapiens_hsa051460.70416834
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70378282
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.69992091
59Steroid biosynthesis_Homo sapiens_hsa001000.68015586
60Gastric acid secretion_Homo sapiens_hsa049710.67917478
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67895045
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.67865362
63Gap junction_Homo sapiens_hsa045400.65706408
64Fatty acid metabolism_Homo sapiens_hsa012120.64692285
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.61025592
66Insulin resistance_Homo sapiens_hsa049310.60891577
67Rap1 signaling pathway_Homo sapiens_hsa040150.60356810
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60324490
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.58501691
70Focal adhesion_Homo sapiens_hsa045100.58410028
71Protein digestion and absorption_Homo sapiens_hsa049740.58215149
72Hepatitis C_Homo sapiens_hsa051600.57988134
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57602506
74Platelet activation_Homo sapiens_hsa046110.57195784
75Renal cell carcinoma_Homo sapiens_hsa052110.56359616
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.56288905
77Oxytocin signaling pathway_Homo sapiens_hsa049210.56169629
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56101281
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.55810430
80Fatty acid degradation_Homo sapiens_hsa000710.55721740
81ErbB signaling pathway_Homo sapiens_hsa040120.54350655
82p53 signaling pathway_Homo sapiens_hsa041150.53018651
83Salivary secretion_Homo sapiens_hsa049700.48187905
84Salmonella infection_Homo sapiens_hsa051320.48151759
85Arginine biosynthesis_Homo sapiens_hsa002200.47761929
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47531723
87Melanoma_Homo sapiens_hsa052180.46817209
88Chemical carcinogenesis_Homo sapiens_hsa052040.45653823
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45296136
90Phototransduction_Homo sapiens_hsa047440.44672414
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44590341
92Dopaminergic synapse_Homo sapiens_hsa047280.44060595
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42994241
94Complement and coagulation cascades_Homo sapiens_hsa046100.42875128
95Prion diseases_Homo sapiens_hsa050200.41715494
96Chronic myeloid leukemia_Homo sapiens_hsa052200.41638409
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37219077
98Amphetamine addiction_Homo sapiens_hsa050310.35078265
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34862934
100Prostate cancer_Homo sapiens_hsa052150.34055542

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