ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	9.93794497
2	virion attachment to host cell (GO:0019062)	9.93794497
3	citrulline biosynthetic process (GO:0019240)	8.72438081
4	peptide cross-linking (GO:0018149)	8.61094417
5	adhesion of symbiont to host (GO:0044406)	8.37151405
6	hair follicle morphogenesis (GO:0031069)	8.36889785
7	intermediate filament cytoskeleton organization (GO:0045104)	6.93261630
8	intermediate filament-based process (GO:0045103)	6.71053073
9	epidermis development (GO:0008544)	6.32809828
10	cell wall macromolecule metabolic process (GO:0044036)	6.02165407
11	cell wall macromolecule catabolic process (GO:0016998)	6.02165407
12	keratinocyte differentiation (GO:0030216)	5.87733046
13	establishment of skin barrier (GO:0061436)	5.82524281
14	citrulline metabolic process (GO:0000052)	5.77449222
15	hair cycle process (GO:0022405)	5.44935702
16	molting cycle process (GO:0022404)	5.44935702
17	regulation of water loss via skin (GO:0033561)	5.17329274
18	hemidesmosome assembly (GO:0031581)	5.07946860
19	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.07215093
20	peptidyl-arginine modification (GO:0018195)	4.81904696
21	epidermal cell differentiation (GO:0009913)	4.57699998
22	skin morphogenesis (GO:0043589)	4.53743003
23	molting cycle (GO:0042303)	34.5625788
24	hair cycle (GO:0042633)	34.5625788
25	keratinocyte development (GO:0003334)	3.84181755
26	tooth mineralization (GO:0034505)	3.70048187
27	multicellular organismal water homeostasis (GO:0050891)	3.46750902
28	regulation of keratinocyte differentiation (GO:0045616)	3.41176676
29	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.39606654
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.38484159
31	hair follicle development (GO:0001942)	3.30126574
32	positive regulation of hair follicle development (GO:0051798)	3.22622602
33	positive regulation of hair cycle (GO:0042635)	3.22622602
34	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.19129240
35	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.09478663
36	bone trabecula formation (GO:0060346)	3.04193991
37	regulation of hair follicle development (GO:0051797)	2.99813942
38	epithelium development (GO:0060429)	2.99692245
39	gap junction assembly (GO:0016264)	2.95790229
40	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.86290880
41	water homeostasis (GO:0030104)	2.83845543
42	positive regulation of meiotic cell cycle (GO:0051446)	2.81521118
43	ectoderm development (GO:0007398)	2.79860290
44	regulation of hair cycle (GO:0042634)	2.77422309
45	positive regulation of epidermis development (GO:0045684)	2.69873546
46	negative regulation of protein localization to plasma membrane (GO:1903077)	2.64516356
47	regulation of epidermal cell differentiation (GO:0045604)	2.63457784
48	fatty acid elongation (GO:0030497)	2.57303040
49	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.51397727
50	regulation of epidermis development (GO:0045682)	2.50414477
51	atrioventricular valve morphogenesis (GO:0003181)	2.46324101
52	positive regulation of monocyte chemotaxis (GO:0090026)	2.33173013
53	ventricular cardiac muscle cell action potential (GO:0086005)	2.32848809
54	phosphatidylserine metabolic process (GO:0006658)	2.32638965
55	wound healing, spreading of epidermal cells (GO:0035313)	2.30669872
56	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.27625157
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.26216034
58	cranial suture morphogenesis (GO:0060363)	2.25585788
59	positive regulation of epidermal cell differentiation (GO:0045606)	2.22698614
60	negative regulation of cell fate specification (GO:0009996)	2.18539159
61	skin development (GO:0043588)	2.11831008
62	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.09528637
63	regulation of ruffle assembly (GO:1900027)	2.05245088
64	aging (GO:0007568)	2.03218051
65	negative regulation of epidermis development (GO:0045683)	2.00999335
66	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.00980075
67	intermediate filament organization (GO:0045109)	12.3926750
68	keratinization (GO:0031424)	12.0044399
69	desmosome organization (GO:0002934)	10.2763712
70	regulation of heart rate by cardiac conduction (GO:0086091)	1.94944382
71	epithelial cell-cell adhesion (GO:0090136)	1.93556196
72	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.93477840
73	regulation of cardioblast differentiation (GO:0051890)	1.92235441
74	lymph vessel development (GO:0001945)	1.90364028
75	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.89472056
76	regulation of keratinocyte proliferation (GO:0010837)	1.88773775
77	cell communication involved in cardiac conduction (GO:0086065)	1.86841532
78	ephrin receptor signaling pathway (GO:0048013)	1.86672056
79	outflow tract septum morphogenesis (GO:0003148)	1.86320389
80	cell-substrate junction assembly (GO:0007044)	1.82495237
81	non-canonical Wnt signaling pathway (GO:0035567)	1.79098306
82	myotube differentiation (GO:0014902)	1.78502144
83	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.78174588
84	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.76902199
85	keratinocyte proliferation (GO:0043616)	1.75909682
86	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.72784925
87	alditol phosphate metabolic process (GO:0052646)	1.71113055
88	regulation of monocyte chemotaxis (GO:0090025)	1.66063502
89	very long-chain fatty acid metabolic process (GO:0000038)	1.65740007
90	negative regulation of epidermal cell differentiation (GO:0045605)	1.64061320
91	establishment of planar polarity (GO:0001736)	1.62967424
92	establishment of tissue polarity (GO:0007164)	1.62967424
93	craniofacial suture morphogenesis (GO:0097094)	1.62648558
94	primary alcohol catabolic process (GO:0034310)	1.62257954
95	wound healing, spreading of cells (GO:0044319)	1.60880423
96	response to UV-B (GO:0010224)	1.57819431
97	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.57597758
98	positive regulation of protein export from nucleus (GO:0046827)	1.55892118
99	eyelid development in camera-type eye (GO:0061029)	1.55480639
100	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.53757936

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.70844127
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.07147135
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.63747119
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.81304016
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.34837862
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.12118331
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.03982519
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.9508237
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.85087356
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.84689069
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.84404241
12	EGR1_19032775_ChIP-ChIP_M12_Human	1.76076491
13	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.73839695
14	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.72607929
15	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.71481588
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.70699951
17	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.69286752
18	ERG_20517297_ChIP-Seq_VCAP_Human	1.67484870
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.63233493
20	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.57556919
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.56404622
22	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.55871809
23	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.55871809
24	BCL6_27268052_Chip-Seq_Bcells_Human	1.50327402
25	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.50303338
26	TP63_22573176_ChIP-Seq_HFKS_Human	1.48525799
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.48211785
28	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.46871550
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.44527944
30	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.44130025
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.42499844
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40876937
33	LXR_22292898_ChIP-Seq_THP-1_Human	1.40648166
34	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.39304420
35	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38815867
36	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.38227784
37	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.35170074
38	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.34617086
39	ATF3_27146783_Chip-Seq_COLON_Human	1.34157089
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.29781481
41	AHR_22903824_ChIP-Seq_MCF-7_Human	1.27787058
42	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25457597
43	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.24980596
44	PHF8_20622854_ChIP-Seq_HELA_Human	1.24062048
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21169556
46	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21115050
47	P68_20966046_ChIP-Seq_HELA_Human	1.20500033
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.20411494
49	CEBPB_22108803_ChIP-Seq_LS180_Human	1.19911849
50	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.17714706
51	TP63_23658742_ChIP-Seq_EP156T_Human	1.15918394
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.15715142
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15635670
54	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11836384
55	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11590773
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.09477289
57	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.09470679
58	TP53_18474530_ChIP-ChIP_U2OS_Human	1.09457503
59	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08526862
60	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.08163347
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06701060
62	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06257005
63	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.06129834
64	SMC4_20622854_ChIP-Seq_HELA_Human	1.03486042
65	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.03313426
66	SOX2_21211035_ChIP-Seq_LN229_Human	1.01338253
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01093247
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00939198
69	SPI1_20517297_ChIP-Seq_HL60_Human	1.00734079
70	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.00545621
71	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.98902280
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97224188
73	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97070493
74	KLF5_25053715_ChIP-Seq_YYC3_Human	0.96656119
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94436834
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92765033
77	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.91843363
78	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90222188
79	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90088350
80	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89467408
81	RXR_22108803_ChIP-Seq_LS180_Human	0.88892923
82	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.87959852
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.87424937
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87052327
85	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.86941332
86	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.86088089
87	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.85949119
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.85056513
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.82814777
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.79436892
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.79368430
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.77641283
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.77641283
94	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.77283612
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.75303113
96	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.74856530
97	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.74667682
98	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.73350601
99	ZNF263_19887448_ChIP-Seq_K562_Human	0.73323330
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.72380942

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.73979881
2	MP0002098_abnormal_vibrissa_morphology	7.12108961
3	MP0000647_abnormal_sebaceous_gland	6.31333601
4	MP0002796_impaired_skin_barrier	5.82443427
5	MP0005275_abnormal_skin_tensile	5.14666887
6	MP0010234_abnormal_vibrissa_follicle	5.02051047
7	MP0000383_abnormal_hair_follicle	4.81365311
8	MP0010678_abnormal_skin_adnexa	4.24114805
9	MP0000377_abnormal_hair_follicle	4.05249263
10	MP0005501_abnormal_skin_physiology	3.63009179
11	MP0003705_abnormal_hypodermis_morpholog	3.60261208
12	MP0000427_abnormal_hair_cycle	3.50081557
13	MP0002254_reproductive_system_inflammat	3.14309400
14	MP0001216_abnormal_epidermal_layer	2.68051151
15	MP0004381_abnormal_hair_follicle	2.55238013
16	MP0000367_abnormal_coat/_hair	2.37027523
17	MP0010771_integument_phenotype	2.32715136
18	MP0004947_skin_inflammation	2.30201212
19	MP0003453_abnormal_keratinocyte_physiol	2.21575896
20	MP0002060_abnormal_skin_morphology	2.18164913
21	MP0001243_abnormal_dermal_layer	2.11221863
22	MP0002234_abnormal_pharynx_morphology	1.86754724
23	MP0000467_abnormal_esophagus_morphology	1.80891379
24	MP0009931_abnormal_skin_appearance	1.51559222
25	MP0000762_abnormal_tongue_morphology	1.51167061
26	MP0009053_abnormal_anal_canal	1.50208976
27	MP0003566_abnormal_cell_adhesion	1.44996470
28	MP0005409_darkened_coat_color	1.42811377
29	MP0003941_abnormal_skin_development	1.30449948
30	MP0004885_abnormal_endolymph	1.00951928
31	MP0001191_abnormal_skin_condition	1.00592965
32	MP0004185_abnormal_adipocyte_glucose	0.95177504
33	MP0004264_abnormal_extraembryonic_tissu	0.93421311
34	MP0002095_abnormal_skin_pigmentation	0.86797185
35	MP0008438_abnormal_cutaneous_collagen	0.86163444
36	MP0001661_extended_life_span	0.78984137
37	MP0001851_eye_inflammation	0.74723304
38	MP0003315_abnormal_perineum_morphology	0.67361712
39	MP0002877_abnormal_melanocyte_morpholog	0.66192997
40	MP0001346_abnormal_lacrimal_gland	0.65666590
41	MP0000566_synostosis	0.65330747
42	MP0001340_abnormal_eyelid_morphology	0.64037293
43	MP0001849_ear_inflammation	0.60542439
44	MP0010030_abnormal_orbit_morphology	0.58234851
45	MP0003191_abnormal_cellular_cholesterol	0.56257799
46	MP0000627_abnormal_mammary_gland	0.55382219
47	MP0002282_abnormal_trachea_morphology	0.52920622
48	MP0005023_abnormal_wound_healing	0.49386815
49	MP0003755_abnormal_palate_morphology	0.48462431
50	MP0005451_abnormal_body_composition	0.47702198
51	MP0009379_abnormal_foot_pigmentation	0.47523655
52	MP0002970_abnormal_white_adipose	0.45773824
53	MP0001784_abnormal_fluid_regulation	0.43945671
54	MP0002111_abnormal_tail_morphology	0.39541335
55	MP0010352_gastrointestinal_tract_polyps	0.36527634
56	MP0004272_abnormal_basement_membrane	0.33191468
57	MP0000537_abnormal_urethra_morphology	0.31152827
58	MP0003385_abnormal_body_wall	0.30489218
59	MP0005075_abnormal_melanosome_morpholog	0.30148817
60	MP0002177_abnormal_outer_ear	0.29889770
61	MP0002249_abnormal_larynx_morphology	0.27429827
62	MP0009840_abnormal_foam_cell	0.26993821
63	MP0003950_abnormal_plasma_membrane	0.26151322
64	MP0002697_abnormal_eye_size	0.26124309
65	MP0003329_amyloid_beta_deposits	0.23073947
66	MP0003763_abnormal_thymus_physiology	0.22780087
67	MP0000465_gastrointestinal_hemorrhage	0.22375383
68	MP0005248_abnormal_Harderian_gland	0.22360679
69	MP0002166_altered_tumor_susceptibility	0.19765079
70	MP0000432_abnormal_head_morphology	0.19575034
71	MP0006054_spinal_hemorrhage	0.19391138
72	MP0002006_tumorigenesis	0.19001940
73	MP0000678_abnormal_parathyroid_gland	0.18451423
74	MP0003300_gastrointestinal_ulcer	0.18155716
75	MP0005666_abnormal_adipose_tissue	0.16831111
76	MP0009384_cardiac_valve_regurgitation	0.15697991
77	MP0004019_abnormal_vitamin_homeostasis	0.15262538
78	MP0003935_abnormal_craniofacial_develop	0.14755651
79	MP0003448_altered_tumor_morphology	0.13486383
80	MP0000604_amyloidosis	0.13422780
81	MP0004742_abnormal_vestibular_system	0.13376156
82	MP0003638_abnormal_response/metabolism_	0.13289254
83	MP0002009_preneoplasia	0.12672445
84	MP0005375_adipose_tissue_phenotype	0.12395298
85	MP0005193_abnormal_anterior_eye	0.10398035
86	MP0005367_renal/urinary_system_phenotyp	0.09894840
87	MP0000516_abnormal_urinary_system	0.09894840
88	MP0005076_abnormal_cell_differentiation	0.09875546
89	MP0001958_emphysema	0.09777508
90	MP0001879_abnormal_lymphatic_vessel	0.09158981
91	MP0004858_abnormal_nervous_system	0.08786650
92	MP0003075_altered_response_to	0.08644072
93	MP0002233_abnormal_nose_morphology	0.08198101
94	MP0003011_delayed_dark_adaptation	0.07074128
95	MP0003045_fibrosis	0.06522161
96	MP0000013_abnormal_adipose_tissue	0.05530924
97	MP0008569_lethality_at_weaning	0.05418283
98	MP0001730_embryonic_growth_arrest	0.05360184
99	MP0000462_abnormal_digestive_system	0.05253346
100	MP0005508_abnormal_skeleton_morphology	0.05221337

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.94144135
2	Nail dystrophy (HP:0008404)	7.48326812
3	Abnormality of nail color (HP:0100643)	6.42300798
4	Abnormal hair laboratory examination (HP:0003328)	5.65911426
5	Fragile nails (HP:0001808)	5.57485126
6	Fine hair (HP:0002213)	5.41896581
7	Alopecia of scalp (HP:0002293)	5.14606776
8	Palmoplantar hyperkeratosis (HP:0000972)	4.79606360
9	Follicular hyperkeratosis (HP:0007502)	4.67946089
10	Thick nail (HP:0001805)	4.63796994
11	Palmar hyperkeratosis (HP:0010765)	4.51693297
12	Onycholysis (HP:0001806)	4.38517104
13	Plantar hyperkeratosis (HP:0007556)	4.36548734
14	Right ventricular cardiomyopathy (HP:0011663)	4.02931097
15	Increased IgE level (HP:0003212)	3.94385823
16	Sparse eyelashes (HP:0000653)	3.58875669
17	Oral leukoplakia (HP:0002745)	3.49546148
18	Erythema (HP:0010783)	3.36027432
19	Parakeratosis (HP:0001036)	3.23781166
20	Milia (HP:0001056)	3.22015904
21	Abnormality of the frontal sinuses (HP:0002687)	3.10890762
22	Amelogenesis imperfecta (HP:0000705)	3.00514064
23	Erythroderma (HP:0001019)	2.83407117
24	Congenital, generalized hypertrichosis (HP:0004540)	2.81835650
25	Ridged nail (HP:0001807)	2.70922328
26	Curly hair (HP:0002212)	2.66019228
27	Intention tremor (HP:0002080)	2.63816922
28	Congenital ichthyosiform erythroderma (HP:0007431)	2.59019638
29	Dry hair (HP:0011359)	2.49037542
30	Aplasia cutis congenita (HP:0001057)	2.42325415
31	Neck muscle weakness (HP:0000467)	2.38740557
32	Abnormal blistering of the skin (HP:0008066)	2.38439290
33	Torticollis (HP:0000473)	2.36405242
34	Natal tooth (HP:0000695)	2.28821422
35	Advanced eruption of teeth (HP:0006288)	2.16045307
36	Hypohidrosis (HP:0000966)	2.12967685
37	Corneal erosion (HP:0200020)	2.10879294
38	Palmoplantar keratoderma (HP:0000982)	2.04293576
39	Hypotrichosis (HP:0001006)	14.8520985
40	Slow-growing hair (HP:0002217)	11.4513222
41	Abnormality of hair growth rate (HP:0011363)	11.4513222
42	Woolly hair (HP:0002224)	11.1054831
43	Brittle hair (HP:0002299)	10.6561579
44	Craniofacial dystonia (HP:0012179)	1.99958325
45	Ventricular tachycardia (HP:0004756)	1.90907178
46	Pruritus (HP:0000989)	1.90742155
47	Concave nail (HP:0001598)	1.85445383
48	Abnormality of the pupil (HP:0000615)	1.85424570
49	Focal dystonia (HP:0004373)	1.82985217
50	Difficulty walking (HP:0002355)	1.81812442
51	Abnormality of the parietal bone (HP:0002696)	1.78001812
52	Abnormality of the dental root (HP:0006486)	1.73878462
53	Taurodontia (HP:0000679)	1.73878462
54	Abnormality of permanent molar morphology (HP:0011071)	1.73878462
55	Ventricular fibrillation (HP:0001663)	1.73791909
56	Abnormality of dental color (HP:0011073)	1.72904584
57	Absent eyelashes (HP:0000561)	1.71970940
58	Abnormality of molar (HP:0011077)	1.71370869
59	Abnormality of molar morphology (HP:0011070)	1.71370869
60	Widely patent fontanelles and sutures (HP:0004492)	1.68739360
61	Recurrent corneal erosions (HP:0000495)	1.66928072
62	Fatigable weakness (HP:0003473)	1.63507384
63	Abnormality of the neuromuscular junction (HP:0003398)	1.63507384
64	Hyporeflexia of lower limbs (HP:0002600)	1.58384981
65	Blepharitis (HP:0000498)	1.56949975
66	Amniotic constriction ring (HP:0009775)	1.53672243
67	Abnormality of placental membranes (HP:0011409)	1.53672243
68	Abnormality of the dental pulp (HP:0006479)	1.51761549
69	Conjunctival hamartoma (HP:0100780)	1.46242242
70	Lip pit (HP:0100267)	1.44298184
71	Keratoconjunctivitis sicca (HP:0001097)	1.43941769
72	Acanthosis nigricans (HP:0000956)	1.43497396
73	Heterogeneous (HP:0001425)	1.42987674
74	Carious teeth (HP:0000670)	1.42223146
75	Sudden death (HP:0001699)	1.37072101
76	Autoamputation (HP:0001218)	1.36928968
77	Anonychia (HP:0001798)	1.34699723
78	Ectropion (HP:0000656)	1.33467650
79	Achilles tendon contracture (HP:0001771)	1.32319962
80	Craniofacial hyperostosis (HP:0004493)	1.32135677
81	Gangrene (HP:0100758)	1.30418925
82	Distal lower limb muscle weakness (HP:0009053)	1.28767924
83	Abnormality of the fingernails (HP:0001231)	1.28423041
84	Keratoconjunctivitis (HP:0001096)	1.26661253
85	Abnormality of the aortic arch (HP:0012303)	1.26484668
86	Unilateral renal agenesis (HP:0000122)	1.25044116
87	Abnormality of the Achilles tendon (HP:0005109)	1.24815550
88	Neonatal onset (HP:0003623)	1.24749175
89	Atrophic scars (HP:0001075)	1.24090269
90	Variable expressivity (HP:0003828)	1.21153685
91	Lack of skin elasticity (HP:0100679)	1.19195646
92	Laryngomalacia (HP:0001601)	1.19103276
93	Widely spaced teeth (HP:0000687)	1.15591138
94	Round ear (HP:0100830)	1.15328432
95	Sparse scalp hair (HP:0002209)	1.13577496
96	Hypergammaglobulinemia (HP:0010702)	1.13081555
97	Hyperhidrosis (HP:0000975)	1.11896034
98	Selective tooth agenesis (HP:0001592)	1.11320116
99	Increased connective tissue (HP:0009025)	1.09296230
100	Corneal dystrophy (HP:0001131)	1.08800159

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.40799006
2	MAPKAPK3	4.08270190
3	FER	3.90962123
4	ERN1	3.84284919
5	MAP3K6	3.55561955
6	EPHB2	3.10589355
7	TAOK1	2.89360437
8	MAP3K3	2.76256101
9	LATS1	2.71256900
10	TRIB3	2.54901995
11	MAP3K2	2.50872683
12	RPS6KB2	1.98096820
13	MAP3K11	1.97168574
14	MAP2K6	1.88322104
15	FGFR2	1.74295746
16	LATS2	1.68366417
17	TTN	1.67698900
18	EEF2K	1.65152827
19	PIK3CG	1.58932838
20	EPHB1	1.55916631
21	BCR	1.48908672
22	NME1	1.36341796
23	MST1R	1.32866802
24	FGFR3	1.28226583
25	MAP3K1	1.28193193
26	FGFR1	1.27132976
27	FGFR4	1.25969828
28	KSR2	1.25796807
29	CDK6	1.23599364
30	RIPK1	1.21700606
31	MAP2K3	1.14335710
32	BMX	1.13773570
33	PDGFRA	1.12345468
34	BLK	1.10625403
35	PKN2	1.09745038
36	PBK	1.08116933
37	PTK6	1.05912581
38	MAPKAPK2	1.04279209
39	LRRK2	1.04202825
40	MAP3K7	0.99418477
41	MAP3K9	0.96616928
42	MAP2K4	0.89318550
43	RPS6KA4	0.85952703
44	MAP2K1	0.80927591
45	STK38	0.78535043
46	PTK2	0.77130671
47	MET	0.75609016
48	SIK1	0.73630240
49	DDR2	0.71784023
50	PAK3	0.70939748
51	STK38L	0.70895538
52	TESK1	0.70577411
53	PIM2	0.70440245
54	ERBB4	0.70352250
55	PRKD1	0.66978139
56	DYRK1B	0.66723271
57	PAK4	0.66171280
58	TRPM7	0.61716440
59	CDK19	0.61165628
60	NTRK2	0.61092367
61	MAP3K5	0.59168118
62	TGFBR1	0.58881578
63	TYRO3	0.56023558
64	PRKCH	0.54381597
65	ERBB3	0.53405737
66	PRKCI	0.51704306
67	ERBB2	0.51189490
68	RET	0.50829664
69	JAK1	0.50662898
70	MAP3K10	0.49813466
71	NEK1	0.49597086
72	MST4	0.49455858
73	ALK	0.47742854
74	TYK2	0.46576550
75	PAK6	0.44835762
76	PAK2	0.44777255
77	CSNK1E	0.43364844
78	EPHA3	0.42890677
79	GSK3A	0.42261871
80	RPS6KA1	0.41985506
81	MAPK12	0.41150990
82	JAK2	0.38558396
83	MAP2K2	0.35414356
84	LIMK1	0.35057842
85	ILK	0.32986808
86	FYN	0.29491547
87	CSNK1A1L	0.28486025
88	TGFBR2	0.27485324
89	MAP3K8	0.26597249
90	SRC	0.26357108
91	GRK6	0.24966787
92	CSNK1A1	0.24890387
93	ROCK2	0.24176271
94	CSNK1D	0.24017297
95	PRKACG	0.23050183
96	MARK3	0.22191262
97	HCK	0.22153904
98	STK11	0.21828803
99	CSNK1G1	0.21433128
100	CSNK1G3	0.21358529

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.86405486
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.83828973
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.07058187
4	Fatty acid elongation_Homo sapiens_hsa00062	2.67509167
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.57809276
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.19642737
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.87030805
8	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.78594225
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.78463927
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.73098905
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.70753228
12	Melanogenesis_Homo sapiens_hsa04916	1.60226565
13	Axon guidance_Homo sapiens_hsa04360	1.54742370
14	Bladder cancer_Homo sapiens_hsa05219	1.41181446
15	Histidine metabolism_Homo sapiens_hsa00340	1.38408948
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37633763
17	Glioma_Homo sapiens_hsa05214	1.35774088
18	Thyroid cancer_Homo sapiens_hsa05216	1.35611527
19	Caffeine metabolism_Homo sapiens_hsa00232	1.32168955
20	Proteoglycans in cancer_Homo sapiens_hsa05205	1.31189938
21	Hippo signaling pathway_Homo sapiens_hsa04390	1.30103688
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.29668070
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.25064172
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.20399208
25	Mineral absorption_Homo sapiens_hsa04978	1.14872328
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14455632
27	Tight junction_Homo sapiens_hsa04530	1.10880001
28	Long-term potentiation_Homo sapiens_hsa04720	1.09844638
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.09796708
30	Pancreatic secretion_Homo sapiens_hsa04972	1.09282500
31	Acute myeloid leukemia_Homo sapiens_hsa05221	1.07803145
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.03956299
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.03143206
34	ECM-receptor interaction_Homo sapiens_hsa04512	0.98841724
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.95982526
36	Adherens junction_Homo sapiens_hsa04520	0.94717108
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94350780
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.91338138
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89864252
40	Non-small cell lung cancer_Homo sapiens_hsa05223	0.89810551
41	Endometrial cancer_Homo sapiens_hsa05213	0.89278444
42	Long-term depression_Homo sapiens_hsa04730	0.87772047
43	Pertussis_Homo sapiens_hsa05133	0.86863213
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.85928365
45	Ras signaling pathway_Homo sapiens_hsa04014	0.83531740
46	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.81428861
47	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81015361
48	Wnt signaling pathway_Homo sapiens_hsa04310	0.78232886
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.77121966
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75504851
51	Amoebiasis_Homo sapiens_hsa05146	0.73808219
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.73147097
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72886789
54	MicroRNAs in cancer_Homo sapiens_hsa05206	0.67119027
55	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66747322
56	Renin secretion_Homo sapiens_hsa04924	0.65585068
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64557339
58	Gastric acid secretion_Homo sapiens_hsa04971	0.63979245
59	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.63180357
60	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63017689
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61759761
62	Hepatitis C_Homo sapiens_hsa05160	0.61393193
63	Gap junction_Homo sapiens_hsa04540	0.57856209
64	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57733237
65	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.57486793
66	Insulin resistance_Homo sapiens_hsa04931	0.57165393
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.57094524
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55951206
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.54364236
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53425371
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52901639
72	Salmonella infection_Homo sapiens_hsa05132	0.52672938
73	Phototransduction_Homo sapiens_hsa04744	0.52617388
74	Focal adhesion_Homo sapiens_hsa04510	0.52001438
75	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.50767178
76	Platelet activation_Homo sapiens_hsa04611	0.50473582
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.50469918
78	Butanoate metabolism_Homo sapiens_hsa00650	0.49913982
79	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48763774
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.48343558
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48096966
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47354535
83	p53 signaling pathway_Homo sapiens_hsa04115	0.44907479
84	Salivary secretion_Homo sapiens_hsa04970	0.44497275
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43262434
86	Fatty acid degradation_Homo sapiens_hsa00071	0.43138792
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41697012
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41255185
89	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41225374
90	Prion diseases_Homo sapiens_hsa05020	0.39410647
91	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.39227022
92	Tuberculosis_Homo sapiens_hsa05152	0.37261170
93	Toxoplasmosis_Homo sapiens_hsa05145	0.36258458
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36091975
95	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.35541242
96	Melanoma_Homo sapiens_hsa05218	0.35304146
97	Prolactin signaling pathway_Homo sapiens_hsa04917	0.33323552
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.33241852
99	Olfactory transduction_Homo sapiens_hsa04740	0.31541626
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.31146638

KRTAP19-5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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