KRTAP2-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)6.35086141
2cell adhesion mediated by integrin (GO:0033627)5.78610040
3hair cycle (GO:0042633)5.32371068
4molting cycle (GO:0042303)5.32371068
5hemidesmosome assembly (GO:0031581)5.22794213
6COPI coating of Golgi vesicle (GO:0048205)4.82116263
7Golgi transport vesicle coating (GO:0048200)4.82116263
8chondrocyte proliferation (GO:0035988)4.71563691
9kidney mesenchyme development (GO:0072074)4.69129696
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.47682769
11cell-substrate junction assembly (GO:0007044)4.14790654
12desmosome organization (GO:0002934)4.13648877
13substrate-dependent cell migration (GO:0006929)4.12671071
14cellular response to vitamin (GO:0071295)4.09941971
15actin filament depolymerization (GO:0030042)4.09298226
16positive regulation of osteoblast proliferation (GO:0033690)4.01460996
17collagen fibril organization (GO:0030199)3.99600609
18endodermal cell differentiation (GO:0035987)3.98471273
19protein localization to endosome (GO:0036010)3.95313228
20hypotonic response (GO:0006971)3.94309704
21cellular response to vitamin D (GO:0071305)3.94235263
22virion attachment to host cell (GO:0019062)3.93524930
23adhesion of symbiont to host cell (GO:0044650)3.93524930
24mesodermal cell differentiation (GO:0048333)3.87261168
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.83340615
26stress fiber assembly (GO:0043149)3.81317690
27membrane raft organization (GO:0031579)3.77499508
28regulation of gonadotropin secretion (GO:0032276)3.67011847
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.66145961
30protein retention in ER lumen (GO:0006621)3.65403654
31type B pancreatic cell proliferation (GO:0044342)3.58461847
32wound healing, spreading of cells (GO:0044319)3.49560715
33atrioventricular valve morphogenesis (GO:0003181)3.47350152
34endocardial cushion development (GO:0003197)3.43153095
35SMAD protein complex assembly (GO:0007183)3.42617611
36keratinocyte proliferation (GO:0043616)3.41562109
37adhesion of symbiont to host (GO:0044406)3.40347891
38heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.39619666
39regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.38201584
40protein maturation by protein folding (GO:0022417)3.37033153
41protein heterotrimerization (GO:0070208)3.35264039
42positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34593348
43regulation of translational termination (GO:0006449)3.29506313
44negative regulation of fatty acid transport (GO:2000192)3.28309624
45pattern specification involved in kidney development (GO:0061004)3.18410460
46focal adhesion assembly (GO:0048041)3.13561861
47cell-substrate adherens junction assembly (GO:0007045)3.13561861
48positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.12580697
49cochlea morphogenesis (GO:0090103)3.10345339
50wound healing, spreading of epidermal cells (GO:0035313)3.10330154
51actin filament bundle organization (GO:0061572)3.08676491
52actin filament bundle assembly (GO:0051017)3.08676491
53extracellular matrix assembly (GO:0085029)3.06914173
54barbed-end actin filament capping (GO:0051016)3.06253997
55negative regulation of stem cell proliferation (GO:2000647)3.04660230
56dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03661069
57protein hydroxylation (GO:0018126)3.03119824
58negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.02422819
59positive regulation of actin filament depolymerization (GO:0030836)2.98600780
60regulation of osteoblast proliferation (GO:0033688)2.96361909
61regulation of plasminogen activation (GO:0010755)2.96338385
62negative regulation of chondrocyte differentiation (GO:0032331)2.93474158
63extracellular fibril organization (GO:0043206)2.91741278
64endothelial cell morphogenesis (GO:0001886)2.89280310
65hippo signaling (GO:0035329)2.88370980
66adherens junction assembly (GO:0034333)2.86440745
67epithelial cell-cell adhesion (GO:0090136)2.85314203
68negative regulation of smooth muscle cell migration (GO:0014912)2.83967146
69sequestering of extracellular ligand from receptor (GO:0035581)2.82036786
70mammary gland epithelial cell proliferation (GO:0033598)2.81901673
71peptidyl-proline hydroxylation (GO:0019511)2.81196983
72endocytic recycling (GO:0032456)2.79909794
73metanephric mesenchyme development (GO:0072075)2.77727040
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.70567891
75bone trabecula formation (GO:0060346)2.68060161
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67772416
77regulation of transforming growth factor beta1 production (GO:0032908)2.66393494
78cortical actin cytoskeleton organization (GO:0030866)2.66216430
79vesicle coating (GO:0006901)2.64637697
80muscle cell migration (GO:0014812)2.61052915
81regulation of early endosome to late endosome transport (GO:2000641)2.60413657
82intermediate filament organization (GO:0045109)2.58784301
83response to gravity (GO:0009629)2.58095131
84negative regulation of protein localization to plasma membrane (GO:1903077)2.57421534
85positive regulation of Rho protein signal transduction (GO:0035025)2.54291546
86substrate adhesion-dependent cell spreading (GO:0034446)2.53209226
87fibril organization (GO:0097435)2.52571514
88basement membrane organization (GO:0071711)2.51383917
89apoptotic cell clearance (GO:0043277)2.50879272
90regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.49115115
91cell migration involved in sprouting angiogenesis (GO:0002042)2.48951253
92positive regulation of positive chemotaxis (GO:0050927)2.47833413
93hyaluronan catabolic process (GO:0030214)2.46750650
94wound healing (GO:0042060)2.45788939
95decidualization (GO:0046697)2.45447799
96protein localization to microtubule (GO:0035372)2.45029674
97positive regulation of endothelial cell apoptotic process (GO:2000353)2.43738375
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42474665
99regulation of protein export from nucleus (GO:0046825)2.42335697
100regulation of growth hormone secretion (GO:0060123)2.41017470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.45896961
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.33249836
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.21142517
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.00458212
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.86850881
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.67733507
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.23876691
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11289132
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.96577276
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.89751814
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.88876016
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.88876016
13BRD4_25478319_ChIP-Seq_HGPS_Human2.88330526
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.37206480
15KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.37033919
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.33384703
17CJUN_26792858_Chip-Seq_BT549_Human2.32629028
18ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.28223907
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.22740267
20ZNF263_19887448_ChIP-Seq_K562_Human2.21133327
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.19260018
22ATF3_27146783_Chip-Seq_COLON_Human2.18290854
23JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13930718
24CLOCK_20551151_ChIP-Seq_293T_Human2.05934818
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03030907
26P300_27058665_Chip-Seq_ZR-75-30cells_Human1.96461555
27JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95908777
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.95540086
29TP53_22127205_ChIP-Seq_IMR90_Human1.90752332
30AR_21909140_ChIP-Seq_LNCAP_Human1.90144897
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.83211364
32UBF1/2_26484160_Chip-Seq_HMECs_Human1.80639689
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.78442890
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73652845
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64433940
36EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.64064899
37TP53_18474530_ChIP-ChIP_U2OS_Human1.62469065
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.60608039
39SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59491944
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58601532
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54002530
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53849187
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.53106246
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50276140
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47126166
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45861090
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44521777
48TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40386255
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.40089926
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35867042
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35608728
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35496494
53TP53_16413492_ChIP-PET_HCT116_Human1.35050308
54NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.33551213
55RACK7_27058665_Chip-Seq_MCF-7_Human1.30356867
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28477801
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.27322511
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.26799274
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.25948168
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25900265
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25120765
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.24786771
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22558855
64SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22064151
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21189251
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20712999
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20472010
68TP53_23651856_ChIP-Seq_MEFs_Mouse1.15563852
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15052329
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13821297
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13821297
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13391661
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.10812155
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.10812155
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.08452662
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06310770
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06112614
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.05063386
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03571136
80SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02427363
81SOX2_20726797_ChIP-Seq_SW620_Human1.01310710
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01161792
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00603791
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00509757
85DCP1A_22483619_ChIP-Seq_HELA_Human0.96547314
86MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95305661
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94318693
88TP63_23658742_ChIP-Seq_EP156T_Human0.93080477
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92190699
90CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89452351
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88563095
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88534105
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87794974
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87739920
95FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87640841
96NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87610096
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87586599
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.86393296
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85734730
100SA1_22415368_ChIP-Seq_MEFs_Mouse0.84560041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.71625971
2MP0003705_abnormal_hypodermis_morpholog4.34459527
3MP0003566_abnormal_cell_adhesion3.72504805
4MP0005257_abnormal_intraocular_pressure3.47303288
5MP0005275_abnormal_skin_tensile3.40609537
6MP0004272_abnormal_basement_membrane3.33040790
7MP0003950_abnormal_plasma_membrane3.28682863
8MP0001958_emphysema3.19678373
9MP0005623_abnormal_meninges_morphology3.12384184
10MP0002877_abnormal_melanocyte_morpholog2.91118059
11MP0009384_cardiac_valve_regurgitation2.89848878
12MP0003279_aneurysm2.87111329
13MP0003941_abnormal_skin_development2.35056176
14MP0010368_abnormal_lymphatic_system2.34297620
15MP0010352_gastrointestinal_tract_polyps2.25119572
16MP0005023_abnormal_wound_healing2.21478548
17MP0002060_abnormal_skin_morphology2.18941885
18MP0001348_abnormal_lacrimal_gland2.04016814
19MP0003091_abnormal_cell_migration1.98245987
20MP0000647_abnormal_sebaceous_gland1.93052073
21MP0001542_abnormal_bone_strength1.80615928
22MP0005503_abnormal_tendon_morphology1.80570715
23MP0000762_abnormal_tongue_morphology1.80360680
24MP0009053_abnormal_anal_canal1.73226858
25MP0000534_abnormal_ureter_morphology1.66897410
26MP0000013_abnormal_adipose_tissue1.66638834
27MP0005501_abnormal_skin_physiology1.62394704
28MP0002163_abnormal_gland_morphology1.60050550
29MP0001299_abnormal_eye_distance/1.58266766
30MP0002796_impaired_skin_barrier1.57668826
31MP0006054_spinal_hemorrhage1.55345374
32MP0000767_abnormal_smooth_muscle1.51539753
33MP0000579_abnormal_nail_morphology1.51218170
34MP0010234_abnormal_vibrissa_follicle1.47809943
35MP0001243_abnormal_dermal_layer1.46403729
36MP0003453_abnormal_keratinocyte_physiol1.43785854
37MP0009250_abnormal_appendicular_skeleto1.29702495
38MP0000003_abnormal_adipose_tissue1.29431242
39MP0004858_abnormal_nervous_system1.28115844
40MP0001849_ear_inflammation1.26861178
41MP0010030_abnormal_orbit_morphology1.21565731
42MP0000733_abnormal_muscle_development1.21076843
43MP0001216_abnormal_epidermal_layer1.20438760
44MP0002896_abnormal_bone_mineralization1.19827465
45MP0005508_abnormal_skeleton_morphology1.17345683
46MP0002098_abnormal_vibrissa_morphology1.16960956
47MP0004233_abnormal_muscle_weight1.15165879
48MP0003942_abnormal_urinary_system1.10531493
49MP0000749_muscle_degeneration1.09973616
50MP0010771_integument_phenotype1.08334073
51MP0003448_altered_tumor_morphology1.07767444
52MP0000751_myopathy1.06262665
53MP0004185_abnormal_adipocyte_glucose1.01240052
54MP0004134_abnormal_chest_morphology1.00159943
55MP0009780_abnormal_chondrocyte_physiolo0.99853579
56MP0000858_altered_metastatic_potential0.98292848
57MP0000427_abnormal_hair_cycle0.97946409
58MP0005197_abnormal_uvea_morphology0.97866260
59MP0005451_abnormal_body_composition0.96493101
60MP0000759_abnormal_skeletal_muscle0.96376900
61MP0000467_abnormal_esophagus_morphology0.96202569
62MP0002295_abnormal_pulmonary_circulatio0.95846708
63MP0003755_abnormal_palate_morphology0.93424444
64MP0002177_abnormal_outer_ear0.91679715
65MP0005595_abnormal_vascular_smooth0.90704021
66MP0000377_abnormal_hair_follicle0.88146368
67MP0003191_abnormal_cellular_cholesterol0.87051550
68MP0005164_abnormal_response_to0.86340800
69MP0003300_gastrointestinal_ulcer0.86289517
70MP0001879_abnormal_lymphatic_vessel0.85936491
71MP0003385_abnormal_body_wall0.82193169
72MP0009697_abnormal_copulation0.79812614
73MP0000428_abnormal_craniofacial_morphol0.78339309
74MP0000678_abnormal_parathyroid_gland0.77755226
75MP0000432_abnormal_head_morphology0.77003821
76MP0010386_abnormal_urinary_bladder0.76552775
77MP0005621_abnormal_cell_physiology0.76411232
78MP0005165_increased_susceptibility_to0.75907871
79MP0008932_abnormal_embryonic_tissue0.75517117
80MP0005409_darkened_coat_color0.72713706
81MP0005193_abnormal_anterior_eye0.70522274
82MP0000627_abnormal_mammary_gland0.67619089
83MP0000163_abnormal_cartilage_morphology0.66166749
84MP0002128_abnormal_blood_circulation0.66122253
85MP0001340_abnormal_eyelid_morphology0.63516784
86MP0006138_congestive_heart_failure0.62372443
87MP0002113_abnormal_skeleton_development0.62135696
88MP0000613_abnormal_salivary_gland0.61998653
89MP0001881_abnormal_mammary_gland0.61200776
90MP0000537_abnormal_urethra_morphology0.59364064
91MP0005390_skeleton_phenotype0.58770761
92MP0002282_abnormal_trachea_morphology0.57450541
93MP0002254_reproductive_system_inflammat0.57118764
94MP0009379_abnormal_foot_pigmentation0.56629988
95MP0004510_myositis0.56377199
96MP0001730_embryonic_growth_arrest0.56356747
97MP0002108_abnormal_muscle_morphology0.56162171
98MP0005379_endocrine/exocrine_gland_phen0.55383939
99MP0008007_abnormal_cellular_replicative0.54779157
100MP0005375_adipose_tissue_phenotype0.54381989

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.98616966
2Protrusio acetabuli (HP:0003179)6.09629825
3Ankle contracture (HP:0006466)4.32144718
4Vascular tortuosity (HP:0004948)4.14046463
5Follicular hyperkeratosis (HP:0007502)4.07579412
6Atrophic scars (HP:0001075)4.06640253
7Aortic dissection (HP:0002647)4.06472981
8Arterial tortuosity (HP:0005116)4.01531918
9Aortic aneurysm (HP:0004942)3.89542420
10Fragile skin (HP:0001030)3.58877655
11Vertebral compression fractures (HP:0002953)3.57902469
12Spinal rigidity (HP:0003306)3.44061181
13Soft skin (HP:0000977)3.31420524
14Abnormality of dentin (HP:0010299)3.29571607
15Wormian bones (HP:0002645)3.25350136
16Onycholysis (HP:0001806)3.17570065
17Upper limb amyotrophy (HP:0009129)3.05464127
18Distal upper limb amyotrophy (HP:0007149)3.05464127
19Bladder diverticulum (HP:0000015)3.05366869
20Short nail (HP:0001799)3.03928521
21Neonatal short-limb short stature (HP:0008921)3.03475506
22Genu recurvatum (HP:0002816)2.98377101
23Type 1 muscle fiber predominance (HP:0003803)2.97317914
24Osteolytic defects of the hand bones (HP:0009699)2.92318660
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.92318660
26Cardiovascular calcification (HP:0011915)2.86536488
27Achilles tendon contracture (HP:0001771)2.85803043
28Spondylolisthesis (HP:0003302)2.83241082
29Distal lower limb amyotrophy (HP:0008944)2.76361141
30Elbow flexion contracture (HP:0002987)2.71028563
31Cervical subluxation (HP:0003308)2.66438259
32Shallow orbits (HP:0000586)2.63058945
33Blue sclerae (HP:0000592)2.58186802
34Mildly elevated creatine phosphokinase (HP:0008180)2.55986946
35Entropion (HP:0000621)2.55367460
36Reduced subcutaneous adipose tissue (HP:0003758)2.53520933
37Abnormality of the Achilles tendon (HP:0005109)2.51002989
38Nail dystrophy (HP:0008404)2.50792246
39Mitral regurgitation (HP:0001653)2.48665531
40Abnormality of the distal phalanges of the toes (HP:0010182)2.48595860
41Slender build (HP:0001533)2.47760678
42Brittle hair (HP:0002299)2.44360799
43Aortic regurgitation (HP:0001659)2.44329310
44Dilatation of the ascending aorta (HP:0005111)2.42552465
45Hand muscle atrophy (HP:0009130)2.36429149
46Broad metatarsal (HP:0001783)2.31831945
47Aortic valve stenosis (HP:0001650)2.27909480
48Ulnar bowing (HP:0003031)2.26691603
49Generalized amyotrophy (HP:0003700)2.25046707
50Hypoventilation (HP:0002791)2.22470818
51Vascular calcification (HP:0004934)2.21399819
52Pili torti (HP:0003777)2.20854276
53Increased connective tissue (HP:0009025)2.19966763
54Biconcave vertebral bodies (HP:0004586)2.19306975
55Lower limb amyotrophy (HP:0007210)2.17606183
56Abnormality of the acetabulum (HP:0003170)2.16435778
57Hyperextensible skin (HP:0000974)2.14985056
58Joint laxity (HP:0001388)2.13788073
59Mitral stenosis (HP:0001718)2.12186188
60Natal tooth (HP:0000695)2.11576028
61Spinal cord lesions (HP:0100561)2.06688661
62Syringomyelia (HP:0003396)2.06688661
63Knee flexion contracture (HP:0006380)2.06304889
64Mitral valve prolapse (HP:0001634)2.05032812
65Autoamputation (HP:0001218)2.01251734
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.00999785
67Difficulty climbing stairs (HP:0003551)1.99692046
68Disproportionate tall stature (HP:0001519)1.99137840
69Bowel diverticulosis (HP:0005222)1.96576034
70Coronal craniosynostosis (HP:0004440)1.94860436
71Hypotrichosis (HP:0001006)1.94833046
72Bradycardia (HP:0001662)1.93445236
73Round ear (HP:0100830)1.93149100
74Delayed gross motor development (HP:0002194)1.91418321
75Distal lower limb muscle weakness (HP:0009053)1.90813352
76Hyperacusis (HP:0010780)1.89639314
77Trismus (HP:0000211)1.89386205
78Aneurysm (HP:0002617)1.86719336
79Fragile nails (HP:0001808)1.85650036
80Hydroureter (HP:0000072)1.85503031
81Abnormal delivery (HP:0001787)1.84302231
82Overgrowth (HP:0001548)1.83861966
83Decreased subcutaneous fat (HP:0001002)1.83678460
84Abnormality of the umbilical cord (HP:0010881)1.83423859
85Selective tooth agenesis (HP:0001592)1.83290605
86Absent frontal sinuses (HP:0002688)1.80616510
87Redundant skin (HP:0001582)1.80265526
88Increased variability in muscle fiber diameter (HP:0003557)1.80264697
89Nemaline bodies (HP:0003798)1.80143486
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80081853
91Peritonitis (HP:0002586)1.75722171
92Coxa vara (HP:0002812)1.74007560
93Increased mean platelet volume (HP:0011877)1.73335234
94Congenital glaucoma (HP:0001087)1.71832213
95Joint stiffness (HP:0001387)1.71763003
96Muscle fiber inclusion bodies (HP:0100299)1.71149622
97Abnormality of skeletal muscle fiber size (HP:0012084)1.71031682
98Long toe (HP:0010511)1.70046804
99Flat cornea (HP:0007720)1.69552514
100Tibial bowing (HP:0002982)1.68196368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.00239915
2PTK23.65224165
3EPHA23.37778366
4LIMK12.93084710
5TESK12.88934424
6PAK42.69382946
7MST1R2.66207982
8TTN2.45669295
9PDGFRA2.40191085
10MAP3K122.36719732
11DMPK2.28844713
12TRIB32.21779485
13LATS22.19236794
14MET2.16705508
15MOS2.02032518
16EPHB21.99637900
17ERBB41.99601399
18ILK1.98673107
19PAK21.97130699
20TGFBR21.95543810
21BUB11.90354246
22NEK91.85945424
23LMTK21.78084217
24STK381.64099158
25IRAK31.62272359
26EPHB11.56465205
27LATS11.54536255
28NTRK11.48968417
29STK101.46585707
30MAP3K31.40411137
31EIF2AK11.35793167
32TESK21.27929053
33SIK11.23634873
34DAPK31.21816656
35TAOK21.19040010
36SCYL21.14926109
37ROCK21.14623798
38PRKD21.13389919
39CDK81.13173320
40ICK1.13060205
41MST41.08880065
42ROCK11.07061564
43FLT31.07023178
44DDR21.06134622
45PAK61.03443271
46ABL21.03429896
47PRKG21.02086411
48TRPM70.98487301
49PTK2B0.97732897
50MAP3K60.97721586
51ARAF0.97509598
52NME20.92610826
53ERN10.91187298
54RIPK10.87963352
55CDK120.81923481
56PIM20.81315107
57PAK10.81194407
58PBK0.77241462
59GRK70.76982827
60PDGFRB0.76468081
61CDK90.76144542
62MAP2K30.75530747
63NEK10.75068541
64MAP3K80.72609640
65PIK3CG0.72292636
66SMG10.64857110
67MTOR0.62162881
68AURKA0.60431792
69STK38L0.55889169
70ADRBK10.54114495
71GSK3A0.52882251
72MELK0.48143512
73NEK20.48089842
74BMX0.47488056
75SIK30.46991303
76CDK70.46503104
77CAMK2G0.45247012
78WNK10.44083840
79KSR10.42961186
80PRKD30.42494684
81MAP3K90.41899698
82AURKB0.40684071
83PTK60.40453278
84RPS6KA20.39861997
85CAMK2D0.38093356
86CDC42BPA0.37940595
87STK40.37617903
88PLK20.37304900
89AKT20.36171555
90CHEK20.35507407
91CAMK2B0.35040943
92STK30.34432084
93MAPKAPK20.32161839
94BRAF0.31109389
95PRKCI0.27758776
96BCR0.27651528
97MAP2K10.27600877
98CDK140.26944797
99MAP3K140.24940325
100CDK11A0.24171196

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.08322299
2ECM-receptor interaction_Homo sapiens_hsa045123.04830722
3Focal adhesion_Homo sapiens_hsa045102.94847660
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.84229921
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.44252820
6Adherens junction_Homo sapiens_hsa045202.40699464
7Proteoglycans in cancer_Homo sapiens_hsa052052.27848529
8Regulation of actin cytoskeleton_Homo sapiens_hsa048102.10517513
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10269567
10Bladder cancer_Homo sapiens_hsa052192.04630959
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96056341
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.93867850
13Shigellosis_Homo sapiens_hsa051311.92611889
14Hippo signaling pathway_Homo sapiens_hsa043901.89539590
15Small cell lung cancer_Homo sapiens_hsa052221.85195810
16Vibrio cholerae infection_Homo sapiens_hsa051101.79831853
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72375239
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56813735
19Amoebiasis_Homo sapiens_hsa051461.56064508
20Pancreatic cancer_Homo sapiens_hsa052121.52877969
21Thyroid cancer_Homo sapiens_hsa052161.49258785
22Dilated cardiomyopathy_Homo sapiens_hsa054141.47192200
23Chronic myeloid leukemia_Homo sapiens_hsa052201.41544675
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40246977
25Tight junction_Homo sapiens_hsa045301.37951286
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.35637791
27Salmonella infection_Homo sapiens_hsa051321.35545027
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.33904952
29MicroRNAs in cancer_Homo sapiens_hsa052061.26675894
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25004645
31p53 signaling pathway_Homo sapiens_hsa041151.24176274
32Melanoma_Homo sapiens_hsa052181.21518485
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.19923258
34Endocytosis_Homo sapiens_hsa041441.17959697
35Renal cell carcinoma_Homo sapiens_hsa052111.12133872
36Proteasome_Homo sapiens_hsa030501.08208520
37Pathways in cancer_Homo sapiens_hsa052001.07758371
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07494683
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06875901
40TGF-beta signaling pathway_Homo sapiens_hsa043501.05940043
41Pentose phosphate pathway_Homo sapiens_hsa000301.00966880
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00349175
43Axon guidance_Homo sapiens_hsa043600.95137628
44Glioma_Homo sapiens_hsa052140.94759559
45N-Glycan biosynthesis_Homo sapiens_hsa005100.92962682
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91804950
47Wnt signaling pathway_Homo sapiens_hsa043100.89839430
48Hedgehog signaling pathway_Homo sapiens_hsa043400.89669154
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89308784
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.86525068
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.86489355
52Rap1 signaling pathway_Homo sapiens_hsa040150.84110592
53Galactose metabolism_Homo sapiens_hsa000520.84032420
54Fatty acid elongation_Homo sapiens_hsa000620.83470756
55Melanogenesis_Homo sapiens_hsa049160.82353578
56Sphingolipid metabolism_Homo sapiens_hsa006000.81029684
57Protein digestion and absorption_Homo sapiens_hsa049740.79340295
58Prostate cancer_Homo sapiens_hsa052150.79125857
59Basal cell carcinoma_Homo sapiens_hsa052170.78921623
60Cell cycle_Homo sapiens_hsa041100.75634317
61Prion diseases_Homo sapiens_hsa050200.75624726
62Sulfur metabolism_Homo sapiens_hsa009200.73574642
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68142925
64Gap junction_Homo sapiens_hsa045400.67308759
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66763892
66ErbB signaling pathway_Homo sapiens_hsa040120.65072875
67Viral carcinogenesis_Homo sapiens_hsa052030.64789018
68Nucleotide excision repair_Homo sapiens_hsa034200.64309738
69Apoptosis_Homo sapiens_hsa042100.64021156
70Sulfur relay system_Homo sapiens_hsa041220.63698073
71Non-small cell lung cancer_Homo sapiens_hsa052230.62187250
72Other glycan degradation_Homo sapiens_hsa005110.60308452
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58563275
74Endometrial cancer_Homo sapiens_hsa052130.58510532
75Ras signaling pathway_Homo sapiens_hsa040140.58497983
76Pyrimidine metabolism_Homo sapiens_hsa002400.58069421
77Colorectal cancer_Homo sapiens_hsa052100.57199969
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56489872
79VEGF signaling pathway_Homo sapiens_hsa043700.56269915
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55974703
81TNF signaling pathway_Homo sapiens_hsa046680.53678075
82Lysosome_Homo sapiens_hsa041420.51897484
83Phagosome_Homo sapiens_hsa041450.49938156
84Hepatitis B_Homo sapiens_hsa051610.48642809
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45834723
86HTLV-I infection_Homo sapiens_hsa051660.44812044
87MAPK signaling pathway_Homo sapiens_hsa040100.44712039
88Biosynthesis of amino acids_Homo sapiens_hsa012300.44089985
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.43833732
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.41916266
91Fructose and mannose metabolism_Homo sapiens_hsa000510.40595132
92Platelet activation_Homo sapiens_hsa046110.39988771
93Inositol phosphate metabolism_Homo sapiens_hsa005620.39751640
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38878086
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36957436
96Estrogen signaling pathway_Homo sapiens_hsa049150.36577053
97AMPK signaling pathway_Homo sapiens_hsa041520.36061955
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.35824299
99Malaria_Homo sapiens_hsa051440.31833470
100RNA transport_Homo sapiens_hsa030130.31187302

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