ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	9.04050067
2	adhesion of symbiont to host (GO:0044406)	8.56029956
3	peptide cross-linking (GO:0018149)	8.46982445
4	hair follicle morphogenesis (GO:0031069)	8.30458555
5	intermediate filament cytoskeleton organization (GO:0045104)	6.77228920
6	intermediate filament-based process (GO:0045103)	6.55693859
7	epidermis development (GO:0008544)	6.10961643
8	cell wall macromolecule metabolic process (GO:0044036)	5.99315585
9	cell wall macromolecule catabolic process (GO:0016998)	5.99315585
10	citrulline metabolic process (GO:0000052)	5.98724664
11	keratinocyte differentiation (GO:0030216)	5.77859785
12	establishment of skin barrier (GO:0061436)	5.68301298
13	hair cycle process (GO:0022405)	5.33146018
14	molting cycle process (GO:0022404)	5.33146018
15	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.18934467
16	regulation of water loss via skin (GO:0033561)	5.03683272
17	peptidyl-arginine modification (GO:0018195)	5.01624371
18	hemidesmosome assembly (GO:0031581)	4.92581950
19	skin morphogenesis (GO:0043589)	4.89831777
20	epidermal cell differentiation (GO:0009913)	4.50354430
21	molting cycle (GO:0042303)	35.1986152
22	hair cycle (GO:0042633)	35.1986152
23	tooth mineralization (GO:0034505)	3.76839432
24	keratinocyte development (GO:0003334)	3.76490560
25	multicellular organismal water homeostasis (GO:0050891)	3.39169533
26	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.37406260
27	negative regulation of keratinocyte proliferation (GO:0010839)	3.34598692
28	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.22053597
29	regulation of keratinocyte differentiation (GO:0045616)	3.16479650
30	positive regulation of hair follicle development (GO:0051798)	3.14895279
31	positive regulation of hair cycle (GO:0042635)	3.14895279
32	hair follicle development (GO:0001942)	3.13399199
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.09523451
34	regulation of hair follicle development (GO:0051797)	2.94856800
35	epithelium development (GO:0060429)	2.88600475
36	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.81824541
37	ectoderm development (GO:0007398)	2.80559558
38	water homeostasis (GO:0030104)	2.77349895
39	gap junction assembly (GO:0016264)	2.73224805
40	positive regulation of epidermis development (GO:0045684)	2.69424135
41	bone trabecula formation (GO:0060346)	2.68840284
42	fatty acid elongation (GO:0030497)	2.67157040
43	negative regulation of protein localization to plasma membrane (GO:1903077)	2.65907445
44	atrioventricular valve morphogenesis (GO:0003181)	2.64597324
45	regulation of hair cycle (GO:0042634)	2.63709195
46	positive regulation of meiotic cell cycle (GO:0051446)	2.59797586
47	regulation of epidermal cell differentiation (GO:0045604)	2.47692533
48	regulation of epidermis development (GO:0045682)	2.40974102
49	ventricular cardiac muscle cell action potential (GO:0086005)	2.40930673
50	phosphatidylserine metabolic process (GO:0006658)	2.33502975
51	negative regulation of cell fate specification (GO:0009996)	2.31776864
52	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.29806383
53	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.25589448
54	positive regulation of epidermal cell differentiation (GO:0045606)	2.21595903
55	lymph vessel development (GO:0001945)	2.18001137
56	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.17716117
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.13259946
58	skin development (GO:0043588)	2.12824258
59	wound healing, spreading of epidermal cells (GO:0035313)	2.09201009
60	positive regulation of monocyte chemotaxis (GO:0090026)	2.08917371
61	aging (GO:0007568)	2.07781425
62	regulation of cardioblast differentiation (GO:0051890)	2.04769180
63	regulation of heart rate by cardiac conduction (GO:0086091)	2.01422643
64	epithelial cell-cell adhesion (GO:0090136)	2.01163444
65	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.00404051
66	intermediate filament organization (GO:0045109)	12.3115078
67	keratinization (GO:0031424)	11.5968506
68	virion attachment to host cell (GO:0019062)	10.1256282
69	adhesion of symbiont to host cell (GO:0044650)	10.1256282
70	desmosome organization (GO:0002934)	10.0952761
71	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.99111243
72	cranial suture morphogenesis (GO:0060363)	1.98673495
73	myotube differentiation (GO:0014902)	1.94866972
74	regulation of ruffle assembly (GO:1900027)	1.92805323
75	outflow tract septum morphogenesis (GO:0003148)	1.92076289
76	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.91880730
77	cell communication involved in cardiac conduction (GO:0086065)	1.89903078
78	negative regulation of epidermis development (GO:0045683)	1.87368830
79	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.85854996
80	regulation of keratinocyte proliferation (GO:0010837)	1.85814053
81	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.80540290
82	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.80540290
83	cell-substrate junction assembly (GO:0007044)	1.79850650
84	ephrin receptor signaling pathway (GO:0048013)	1.79369277
85	non-canonical Wnt signaling pathway (GO:0035567)	1.73548771
86	alditol phosphate metabolic process (GO:0052646)	1.72933533
87	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.70794816
88	coronary vasculature morphogenesis (GO:0060977)	1.69520864
89	primary alcohol catabolic process (GO:0034310)	1.69327386
90	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.67426258
91	regulation of cardioblast proliferation (GO:0003264)	1.67426258
92	very long-chain fatty acid metabolic process (GO:0000038)	1.66835918
93	negative regulation of cell fate commitment (GO:0010454)	1.60119944
94	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.58666101
95	establishment of planar polarity (GO:0001736)	1.58563335
96	establishment of tissue polarity (GO:0007164)	1.58563335
97	cardiac conduction (GO:0061337)	1.57075962
98	cellular modified amino acid biosynthetic process (GO:0042398)	1.56504898
99	outer ear morphogenesis (GO:0042473)	1.53981245
100	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.53841443

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.40381165
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.83951096
3	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.42161698
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.64982709
5	* CTCF_20526341_ChIP-Seq_ESCs_Human	2.21945536
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.20661272
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.18991407
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.7080135
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.91637300
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.87960371
11	EGR1_19032775_ChIP-ChIP_M12_Human	1.76627773
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75563590
13	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.69659207
14	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.67347582
15	CTCF_27219007_Chip-Seq_Bcells_Human	1.61962517
16	ERG_20517297_ChIP-Seq_VCAP_Human	1.61245766
17	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.59371462
18	* CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.59212537
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.58582040
20	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.58417683
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54086573
22	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.52164373
23	LXR_22292898_ChIP-Seq_THP-1_Human	1.51770712
24	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.51750213
25	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51627662
26	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.51611861
27	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.51611861
28	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.50929080
29	TP63_22573176_ChIP-Seq_HFKS_Human	1.50558386
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.50290282
31	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49970484
32	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.46379472
33	BCOR_27268052_Chip-Seq_Bcells_Human	1.42231433
34	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.37112154
35	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.36772173
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36639255
37	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.32305746
38	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.28295268
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28133365
40	PHF8_20622854_ChIP-Seq_HELA_Human	1.27114540
41	* ATF3_27146783_Chip-Seq_COLON_Human	1.23323936
42	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.22904934
43	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22656596
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22256365
45	P68_20966046_ChIP-Seq_HELA_Human	1.20599606
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19269022
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18845801
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.18182880
49	CEBPB_22108803_ChIP-Seq_LS180_Human	1.16553331
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16392855
51	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.15971336
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.14883886
53	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.13965485
54	RAC3_21632823_ChIP-Seq_H3396_Human	1.13106075
55	SMC4_20622854_ChIP-Seq_HELA_Human	1.11629077
56	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10368561
57	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.10204573
58	TP63_23658742_ChIP-Seq_EP156T_Human	1.07272125
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06634910
60	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06270298
61	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.06232500
62	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.06017519
63	GATA4_25053715_ChIP-Seq_YYC3_Human	1.05401392
64	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.05363021
65	SPI1_20517297_ChIP-Seq_HL60_Human	1.02494441
66	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.02469403
67	SOX2_21211035_ChIP-Seq_LN229_Human	1.01302148
68	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.01188470
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00272986
70	KLF5_25053715_ChIP-Seq_YYC3_Human	0.97775845
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96768539
72	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.96154287
73	* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.96118506
74	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.95436168
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93972634
76	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93895265
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92022420
78	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91026129
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90471448
80	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.89821155
81	TP53_18474530_ChIP-ChIP_U2OS_Human	0.88884682
82	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87262885
83	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86906189
84	RXR_22108803_ChIP-Seq_LS180_Human	0.85546618
85	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.85024944
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.84604106
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.83661988
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.83594698
89	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.81929168
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80171478
91	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.79424211
92	ZNF263_19887448_ChIP-Seq_K562_Human	0.78799294
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.78575127
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77598662
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.75912112
96	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.74890392
97	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74000733
98	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.73277560
99	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.72504492
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.71616930

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.74338924
2	MP0002098_abnormal_vibrissa_morphology	7.18521744
3	MP0000647_abnormal_sebaceous_gland	6.44960993
4	MP0002796_impaired_skin_barrier	5.92389210
5	MP0005275_abnormal_skin_tensile	5.12769600
6	MP0010234_abnormal_vibrissa_follicle	5.09811913
7	MP0000383_abnormal_hair_follicle	4.54466080
8	MP0000377_abnormal_hair_follicle	4.09856367
9	MP0010678_abnormal_skin_adnexa	4.03112071
10	MP0003705_abnormal_hypodermis_morpholog	3.74393299
11	MP0005501_abnormal_skin_physiology	3.72444122
12	MP0000427_abnormal_hair_cycle	3.47697139
13	MP0002254_reproductive_system_inflammat	2.95309725
14	MP0001216_abnormal_epidermal_layer	2.67463650
15	MP0004381_abnormal_hair_follicle	2.60781380
16	MP0000367_abnormal_coat/_hair	2.37556972
17	MP0004947_skin_inflammation	2.32442775
18	MP0010771_integument_phenotype	2.29760920
19	MP0003453_abnormal_keratinocyte_physiol	2.20195890
20	MP0002060_abnormal_skin_morphology	2.13028610
21	MP0001243_abnormal_dermal_layer	2.12615935
22	MP0002234_abnormal_pharynx_morphology	2.07625523
23	MP0000467_abnormal_esophagus_morphology	1.81302019
24	MP0009053_abnormal_anal_canal	1.50926807
25	MP0000762_abnormal_tongue_morphology	1.50525498
26	MP0009931_abnormal_skin_appearance	1.49602160
27	MP0003566_abnormal_cell_adhesion	1.46803166
28	MP0005409_darkened_coat_color	1.38749811
29	MP0003941_abnormal_skin_development	1.15619878
30	MP0001191_abnormal_skin_condition	0.99350307
31	MP0004885_abnormal_endolymph	0.94950420
32	MP0004185_abnormal_adipocyte_glucose	0.87150895
33	MP0004264_abnormal_extraembryonic_tissu	0.85288172
34	MP0001851_eye_inflammation	0.83408171
35	MP0002095_abnormal_skin_pigmentation	0.79077482
36	MP0003315_abnormal_perineum_morphology	0.68383164
37	MP0001849_ear_inflammation	0.67791879
38	MP0008438_abnormal_cutaneous_collagen	0.65986634
39	MP0001340_abnormal_eyelid_morphology	0.63512006
40	MP0002877_abnormal_melanocyte_morpholog	0.62046717
41	MP0001346_abnormal_lacrimal_gland	0.61010666
42	MP0001661_extended_life_span	0.60763741
43	MP0010030_abnormal_orbit_morphology	0.56713976
44	MP0003191_abnormal_cellular_cholesterol	0.55544565
45	MP0005451_abnormal_body_composition	0.54676306
46	MP0000627_abnormal_mammary_gland	0.54573594
47	MP0002282_abnormal_trachea_morphology	0.52778258
48	MP0000566_synostosis	0.51526135
49	MP0003755_abnormal_palate_morphology	0.49461292
50	MP0005023_abnormal_wound_healing	0.48734279
51	MP0002970_abnormal_white_adipose	0.47260349
52	MP0001784_abnormal_fluid_regulation	0.45079160
53	MP0002249_abnormal_larynx_morphology	0.40660791
54	MP0000678_abnormal_parathyroid_gland	0.39058373
55	MP0002111_abnormal_tail_morphology	0.38603694
56	MP0005075_abnormal_melanosome_morpholog	0.37431294
57	MP0009840_abnormal_foam_cell	0.36389134
58	MP0010352_gastrointestinal_tract_polyps	0.32683678
59	MP0004272_abnormal_basement_membrane	0.32491398
60	MP0003385_abnormal_body_wall	0.29969431
61	MP0003329_amyloid_beta_deposits	0.28380269
62	MP0000465_gastrointestinal_hemorrhage	0.27809085
63	MP0002177_abnormal_outer_ear	0.27014770
64	MP0000537_abnormal_urethra_morphology	0.26561997
65	MP0003763_abnormal_thymus_physiology	0.25638222
66	MP0003950_abnormal_plasma_membrane	0.24911299
67	MP0002697_abnormal_eye_size	0.23514139
68	MP0005248_abnormal_Harderian_gland	0.22139142
69	MP0004019_abnormal_vitamin_homeostasis	0.20886453
70	MP0003300_gastrointestinal_ulcer	0.20711143
71	MP0004742_abnormal_vestibular_system	0.18509850
72	MP0001879_abnormal_lymphatic_vessel	0.17984120
73	MP0006054_spinal_hemorrhage	0.16727306
74	MP0000432_abnormal_head_morphology	0.15837538
75	MP0000604_amyloidosis	0.15424953
76	MP0003011_delayed_dark_adaptation	0.15403741
77	MP0005666_abnormal_adipose_tissue	0.14742313
78	MP0003448_altered_tumor_morphology	0.14671292
79	MP0004858_abnormal_nervous_system	0.14249400
80	MP0005375_adipose_tissue_phenotype	0.13775212
81	MP0003935_abnormal_craniofacial_develop	0.13735443
82	MP0003638_abnormal_response/metabolism_	0.13668018
83	MP0003075_altered_response_to	0.11970500
84	MP0002233_abnormal_nose_morphology	0.10499529
85	MP0005367_renal/urinary_system_phenotyp	0.09914997
86	MP0000516_abnormal_urinary_system	0.09914997
87	MP0005193_abnormal_anterior_eye	0.09895851
88	MP0005076_abnormal_cell_differentiation	0.09321927
89	MP0010368_abnormal_lymphatic_system	0.08382892
90	MP0003045_fibrosis	0.08359764
91	MP0000462_abnormal_digestive_system	0.07983905
92	MP0008569_lethality_at_weaning	0.07873742
93	MP0002006_tumorigenesis	0.07740933
94	MP0000733_abnormal_muscle_development	0.07596557
95	MP0001958_emphysema	0.07080110
96	MP0002166_altered_tumor_susceptibility	0.06975234
97	MP0005165_increased_susceptibility_to	0.06257404
98	MP0006138_congestive_heart_failure	0.05905669
99	MP0000751_myopathy	0.05669175
100	MP0002090_abnormal_vision	0.05500348

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.06504185
2	Nail dystrophy (HP:0008404)	7.39434640
3	Abnormality of nail color (HP:0100643)	6.51858195
4	Abnormal hair laboratory examination (HP:0003328)	5.73281562
5	Fragile nails (HP:0001808)	5.58364978
6	Fine hair (HP:0002213)	5.26543077
7	Alopecia of scalp (HP:0002293)	4.99535189
8	Palmoplantar hyperkeratosis (HP:0000972)	4.97332457
9	Onycholysis (HP:0001806)	4.90778972
10	Increased IgE level (HP:0003212)	4.80412184
11	Thick nail (HP:0001805)	4.77050578
12	Palmar hyperkeratosis (HP:0010765)	4.68239070
13	Plantar hyperkeratosis (HP:0007556)	4.50720657
14	Follicular hyperkeratosis (HP:0007502)	4.38580323
15	Right ventricular cardiomyopathy (HP:0011663)	4.24562630
16	Erythema (HP:0010783)	3.61100089
17	Sparse eyelashes (HP:0000653)	3.55803282
18	Oral leukoplakia (HP:0002745)	3.53304250
19	Milia (HP:0001056)	3.25040031
20	Amelogenesis imperfecta (HP:0000705)	3.06727880
21	Abnormality of the frontal sinuses (HP:0002687)	3.03005435
22	Erythroderma (HP:0001019)	2.99057274
23	Parakeratosis (HP:0001036)	2.93788577
24	Ridged nail (HP:0001807)	2.75259752
25	Curly hair (HP:0002212)	2.69611993
26	Intention tremor (HP:0002080)	2.64850747
27	Congenital, generalized hypertrichosis (HP:0004540)	2.59725574
28	Abnormal blistering of the skin (HP:0008066)	2.47603205
29	Congenital ichthyosiform erythroderma (HP:0007431)	2.45691935
30	Neck muscle weakness (HP:0000467)	2.43032126
31	Natal tooth (HP:0000695)	2.42902052
32	Torticollis (HP:0000473)	2.36664826
33	Aplasia cutis congenita (HP:0001057)	2.35742124
34	Dry hair (HP:0011359)	2.35644533
35	Advanced eruption of teeth (HP:0006288)	2.34097883
36	Hypohidrosis (HP:0000966)	2.11861249
37	Corneal erosion (HP:0200020)	2.06745621
38	Palmoplantar keratoderma (HP:0000982)	2.04195491
39	Ventricular tachycardia (HP:0004756)	2.02158147
40	Craniofacial dystonia (HP:0012179)	2.01231731
41	Hypotrichosis (HP:0001006)	14.7992603
42	Abnormality of hair growth rate (HP:0011363)	11.1766399
43	Slow-growing hair (HP:0002217)	11.1766399
44	Woolly hair (HP:0002224)	11.0996000
45	Brittle hair (HP:0002299)	10.3955065
46	Pruritus (HP:0000989)	1.92528243
47	Difficulty walking (HP:0002355)	1.89615296
48	Focal dystonia (HP:0004373)	1.84036626
49	Ventricular fibrillation (HP:0001663)	1.82132078
50	Abnormality of the pupil (HP:0000615)	1.81148928
51	Abnormality of the neuromuscular junction (HP:0003398)	1.73285668
52	Fatigable weakness (HP:0003473)	1.73285668
53	Abnormality of permanent molar morphology (HP:0011071)	1.71425381
54	Abnormality of the dental root (HP:0006486)	1.71425381
55	Taurodontia (HP:0000679)	1.71425381
56	Concave nail (HP:0001598)	1.70969690
57	Abnormality of dental color (HP:0011073)	1.70073394
58	Abnormality of the parietal bone (HP:0002696)	1.68655135
59	Abnormality of molar morphology (HP:0011070)	1.68218773
60	Abnormality of molar (HP:0011077)	1.68218773
61	Conjunctival hamartoma (HP:0100780)	1.66823172
62	Widely patent fontanelles and sutures (HP:0004492)	1.62502461
63	Absent eyelashes (HP:0000561)	1.61392568
64	Recurrent corneal erosions (HP:0000495)	1.57829358
65	Blepharitis (HP:0000498)	1.55621494
66	Unilateral renal agenesis (HP:0000122)	1.55196443
67	Abnormality of the aortic arch (HP:0012303)	1.53981140
68	Hyporeflexia of lower limbs (HP:0002600)	1.50340115
69	Abnormality of the dental pulp (HP:0006479)	1.49677072
70	Sudden death (HP:0001699)	1.48142355
71	Amniotic constriction ring (HP:0009775)	1.47881472
72	Abnormality of placental membranes (HP:0011409)	1.47881472
73	Acanthosis nigricans (HP:0000956)	1.43920311
74	Heterogeneous (HP:0001425)	1.43426418
75	Hypergammaglobulinemia (HP:0010702)	1.42301443
76	Carious teeth (HP:0000670)	1.41914685
77	Anonychia (HP:0001798)	1.40471070
78	Gangrene (HP:0100758)	1.38739097
79	Ectropion (HP:0000656)	1.36171831
80	Lip pit (HP:0100267)	1.35149596
81	Keratoconjunctivitis sicca (HP:0001097)	1.33801796
82	Achilles tendon contracture (HP:0001771)	1.31672276
83	Laryngomalacia (HP:0001601)	1.29947696
84	Autoamputation (HP:0001218)	1.29928808
85	Neonatal onset (HP:0003623)	1.29826626
86	Abnormality of the fingernails (HP:0001231)	1.28970287
87	Craniofacial hyperostosis (HP:0004493)	1.28475825
88	Distal lower limb muscle weakness (HP:0009053)	1.26497112
89	Abnormality of the Achilles tendon (HP:0005109)	1.23878619
90	Variable expressivity (HP:0003828)	1.20860944
91	Keratoconjunctivitis (HP:0001096)	1.17434427
92	Selective tooth agenesis (HP:0001592)	1.17152568
93	Hyperhidrosis (HP:0000975)	1.16970394
94	Sparse scalp hair (HP:0002209)	1.16562877
95	Corneal dystrophy (HP:0001131)	1.14476059
96	Lack of skin elasticity (HP:0100679)	1.13770690
97	Widely spaced teeth (HP:0000687)	1.13641866
98	Round ear (HP:0100830)	1.11365528
99	Abnormality of the gastric mucosa (HP:0004295)	1.11157899
100	Atrophic scars (HP:0001075)	1.10467597

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.30259998
2	FER	4.23943164
3	MAPKAPK3	4.04386914
4	MAP3K6	3.94351904
5	ERN1	3.92402047
6	EPHB2	3.11140811
7	TAOK1	3.10614610
8	MAP3K3	2.71625263
9	TRIB3	2.69561832
10	MAP3K2	2.34971006
11	LATS1	2.21653894
12	MAP3K11	2.12030071
13	RPS6KB2	1.98603999
14	EEF2K	1.93032877
15	EPHB1	1.91533951
16	MAP2K6	1.74994888
17	TTN	1.70403187
18	PIK3CG	1.67237768
19	LATS2	1.54154503
20	FGFR4	1.40951407
21	MAP3K1	1.35539011
22	BCR	1.34248597
23	NME1	1.31150802
24	MAP2K3	1.28669343
25	BLK	1.22894421
26	BMX	1.22753206
27	RIPK1	1.22601818
28	PKN2	1.21302679
29	KSR2	1.19416468
30	MST1R	1.13391260
31	CDK6	1.09957853
32	MAPKAPK2	1.09578650
33	FGFR1	1.08323512
34	FGFR2	1.07181904
35	PDGFRA	1.04188893
36	FGFR3	1.03106831
37	LRRK2	1.02393049
38	PTK6	1.00416917
39	MAP3K7	0.95556494
40	MAP3K9	0.93970121
41	MAP2K4	0.92686054
42	RPS6KA4	0.91257260
43	SIK1	0.87040441
44	PBK	0.84507420
45	PTK2	0.83410836
46	MAP2K1	0.79467442
47	PAK4	0.73542990
48	STK38	0.73188150
49	MAP3K10	0.71311153
50	CDK19	0.70188151
51	PRKD1	0.69859531
52	PIM2	0.69791015
53	PAK3	0.69143785
54	TESK1	0.67641634
55	MET	0.66542856
56	DDR2	0.66035604
57	DYRK1B	0.65810280
58	STK38L	0.62590065
59	TYK2	0.60259015
60	TGFBR1	0.59499583
61	JAK1	0.59181586
62	PRKCH	0.57851687
63	PRKCI	0.53787489
64	TRPM7	0.53269798
65	MAP3K5	0.53250126
66	RET	0.53076737
67	PAK6	0.52506892
68	TYRO3	0.52233935
69	PAK2	0.51909573
70	ERBB4	0.51622164
71	NTRK2	0.51130992
72	EPHA3	0.50043397
73	OBSCN	0.47878231
74	MAPK12	0.46782140
75	ERBB2	0.46639375
76	RPS6KA1	0.46190803
77	ALK	0.45041546
78	CLK1	0.38973131
79	GSK3A	0.38559941
80	MAP2K2	0.38087265
81	GRK6	0.37914945
82	NEK1	0.37445841
83	CSNK1E	0.37136977
84	MST4	0.36657441
85	JAK2	0.36476127
86	TGFBR2	0.34471114
87	FYN	0.32319890
88	MAP3K8	0.30831818
89	ILK	0.27869576
90	HCK	0.27236478
91	MAP4K1	0.27074847
92	LIMK1	0.25742614
93	SRC	0.24923269
94	CSNK1A1	0.23955796
95	ROCK2	0.22357119
96	PRKACG	0.22259103
97	NTRK1	0.21490937
98	MAPKAPK5	0.21078512
99	MATK	0.20521350
100	MAPK8	0.20466593

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	5.04264095
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.97849963
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.27917957
4	Fatty acid elongation_Homo sapiens_hsa00062	2.90063507
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.66863631
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.11936744
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.94047031
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.83979383
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.82164714
10	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.81755455
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.68427672
12	Melanogenesis_Homo sapiens_hsa04916	1.51334678
13	Axon guidance_Homo sapiens_hsa04360	1.50241197
14	Caffeine metabolism_Homo sapiens_hsa00232	1.50183657
15	Histidine metabolism_Homo sapiens_hsa00340	1.40972530
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.30749042
17	Glioma_Homo sapiens_hsa05214	1.29147482
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.29034995
19	Bladder cancer_Homo sapiens_hsa05219	1.26095685
20	Thyroid cancer_Homo sapiens_hsa05216	1.23517097
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.22391072
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.20932352
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.18263600
24	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.17977416
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.15649661
26	Steroid biosynthesis_Homo sapiens_hsa00100	1.14335240
27	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14102481
28	Pancreatic secretion_Homo sapiens_hsa04972	1.10357033
29	Tight junction_Homo sapiens_hsa04530	1.08203221
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.06292367
31	Mineral absorption_Homo sapiens_hsa04978	1.05091145
32	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.01855223
33	Nitrogen metabolism_Homo sapiens_hsa00910	0.98340571
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.96554731
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95922451
36	Long-term potentiation_Homo sapiens_hsa04720	0.94793622
37	ECM-receptor interaction_Homo sapiens_hsa04512	0.93070450
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.90731387
39	Adherens junction_Homo sapiens_hsa04520	0.90653274
40	Pertussis_Homo sapiens_hsa05133	0.88058726
41	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.84642116
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.82956950
43	Ras signaling pathway_Homo sapiens_hsa04014	0.81546121
44	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81524909
45	Endometrial cancer_Homo sapiens_hsa05213	0.80694755
46	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.80308683
47	Estrogen signaling pathway_Homo sapiens_hsa04915	0.79037113
48	Long-term depression_Homo sapiens_hsa04730	0.77366639
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.75529242
50	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.74173885
51	Amoebiasis_Homo sapiens_hsa05146	0.73912438
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.70012218
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.69837928
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.69651564
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67693878
56	Gastric acid secretion_Homo sapiens_hsa04971	0.65242865
57	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.62106495
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.61375470
59	Hepatitis C_Homo sapiens_hsa05160	0.60730753
60	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.60716533
61	Renin secretion_Homo sapiens_hsa04924	0.59704044
62	Phototransduction_Homo sapiens_hsa04744	0.59209929
63	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.58891040
64	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.57290089
65	Insulin resistance_Homo sapiens_hsa04931	0.56845991
66	Salmonella infection_Homo sapiens_hsa05132	0.56117980
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55037118
68	MicroRNAs in cancer_Homo sapiens_hsa05206	0.53656699
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52918230
70	Gap junction_Homo sapiens_hsa04540	0.50657408
71	Salivary secretion_Homo sapiens_hsa04970	0.49056988
72	Butanoate metabolism_Homo sapiens_hsa00650	0.48810490
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48152550
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47477046
75	Fatty acid degradation_Homo sapiens_hsa00071	0.47266291
76	Renal cell carcinoma_Homo sapiens_hsa05211	0.46912433
77	Platelet activation_Homo sapiens_hsa04611	0.45994883
78	Focal adhesion_Homo sapiens_hsa04510	0.45795028
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45444271
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.44850583
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.44832807
82	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.44480190
83	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44265896
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43997916
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43595288
86	Protein digestion and absorption_Homo sapiens_hsa04974	0.42303492
87	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40395948
88	Toxoplasmosis_Homo sapiens_hsa05145	0.40092879
89	Tuberculosis_Homo sapiens_hsa05152	0.39875047
90	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38044249
91	Prion diseases_Homo sapiens_hsa05020	0.37479855
92	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36296649
93	Olfactory transduction_Homo sapiens_hsa04740	0.36160897
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35434115
95	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.35172164
96	Notch signaling pathway_Homo sapiens_hsa04330	0.34202395
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.32206237
98	Insulin signaling pathway_Homo sapiens_hsa04910	0.31488688
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30363922
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.30277408

KRTAP2-4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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