ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.60201343
2	adhesion of symbiont to host cell (GO:0044650)	9.60201343
3	peptide cross-linking (GO:0018149)	8.78346200
4	citrulline biosynthetic process (GO:0019240)	8.15806266
5	adhesion of symbiont to host (GO:0044406)	8.09161189
6	hair follicle morphogenesis (GO:0031069)	7.80813879
7	establishment of skin barrier (GO:0061436)	7.63731097
8	intermediate filament cytoskeleton organization (GO:0045104)	6.99183078
9	intermediate filament-based process (GO:0045103)	6.76902417
10	regulation of water loss via skin (GO:0033561)	6.68020437
11	epidermis development (GO:0008544)	6.57197811
12	keratinocyte differentiation (GO:0030216)	6.36368388
13	cell wall macromolecule catabolic process (GO:0016998)	6.32513241
14	cell wall macromolecule metabolic process (GO:0044036)	6.32513241
15	hemidesmosome assembly (GO:0031581)	5.91317651
16	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.48374978
17	citrulline metabolic process (GO:0000052)	5.38653476
18	skin morphogenesis (GO:0043589)	5.23561865
19	hair cycle process (GO:0022405)	5.20595268
20	molting cycle process (GO:0022404)	5.20595268
21	epidermal cell differentiation (GO:0009913)	4.93623183
22	peptidyl-arginine modification (GO:0018195)	4.48652873
23	multicellular organismal water homeostasis (GO:0050891)	4.45170049
24	molting cycle (GO:0042303)	33.4936638
25	hair cycle (GO:0042633)	33.4936638
26	keratinocyte development (GO:0003334)	3.90368700
27	tooth mineralization (GO:0034505)	3.75674666
28	water homeostasis (GO:0030104)	3.65396514
29	negative regulation of keratinocyte proliferation (GO:0010839)	3.47818819
30	ectoderm development (GO:0007398)	3.46168330
31	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.39264506
32	fatty acid elongation (GO:0030497)	3.28043537
33	hair follicle development (GO:0001942)	3.27893794
34	regulation of keratinocyte differentiation (GO:0045616)	3.19032025
35	positive regulation of hair cycle (GO:0042635)	3.18078847
36	positive regulation of hair follicle development (GO:0051798)	3.18078847
37	epithelium development (GO:0060429)	3.10077252
38	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.08972960
39	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.07306027
40	regulation of hair follicle development (GO:0051797)	2.98967321
41	bone trabecula formation (GO:0060346)	2.98400761
42	gap junction assembly (GO:0016264)	2.89857067
43	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.75145677
44	regulation of hair cycle (GO:0042634)	2.74648161
45	positive regulation of epidermis development (GO:0045684)	2.74503450
46	atrioventricular valve morphogenesis (GO:0003181)	2.71237330
47	positive regulation of meiotic cell cycle (GO:0051446)	2.65323950
48	negative regulation of protein localization to plasma membrane (GO:1903077)	2.55343853
49	regulation of epidermal cell differentiation (GO:0045604)	2.49349817
50	skin development (GO:0043588)	2.47415933
51	negative regulation of cell fate specification (GO:0009996)	2.46508018
52	regulation of epidermis development (GO:0045682)	2.44810744
53	ventricular cardiac muscle cell action potential (GO:0086005)	2.44721541
54	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.33827509
55	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.31320629
56	phosphatidylserine metabolic process (GO:0006658)	2.30139241
57	positive regulation of epidermal cell differentiation (GO:0045606)	2.27275342
58	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.27136860
59	positive regulation of monocyte chemotaxis (GO:0090026)	2.22557396
60	wound healing, spreading of epidermal cells (GO:0035313)	2.21916848
61	keratinocyte proliferation (GO:0043616)	2.20826555
62	lymph vessel development (GO:0001945)	2.15251859
63	regulation of cardioblast differentiation (GO:0051890)	2.14151945
64	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.13790474
65	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.12534900
66	cranial suture morphogenesis (GO:0060363)	2.09105250
67	cell-substrate junction assembly (GO:0007044)	2.08171016
68	epithelial cell-cell adhesion (GO:0090136)	2.07491110
69	regulation of heart rate by cardiac conduction (GO:0086091)	2.04415295
70	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.03728234
71	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.03244828
72	keratinization (GO:0031424)	13.3997690
73	intermediate filament organization (GO:0045109)	12.3355872
74	desmosome organization (GO:0002934)	10.7346225
75	regulation of ruffle assembly (GO:1900027)	1.99789104
76	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.99654604
77	aging (GO:0007568)	1.96711495
78	regulation of keratinocyte proliferation (GO:0010837)	1.96290625
79	cell communication involved in cardiac conduction (GO:0086065)	1.95013168
80	myotube differentiation (GO:0014902)	1.93997356
81	very long-chain fatty acid metabolic process (GO:0000038)	1.89794571
82	outflow tract septum morphogenesis (GO:0003148)	1.89044385
83	negative regulation of epidermis development (GO:0045683)	1.88777597
84	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.88181872
85	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.88015584
86	non-canonical Wnt signaling pathway (GO:0035567)	1.85399958
87	ephrin receptor signaling pathway (GO:0048013)	1.82219511
88	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	1.78921812
89	fatty-acyl-CoA biosynthetic process (GO:0046949)	1.74274118
90	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.74162641
91	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.74162641
92	primary alcohol catabolic process (GO:0034310)	1.72391544
93	establishment of planar polarity (GO:0001736)	1.69743494
94	establishment of tissue polarity (GO:0007164)	1.69743494
95	negative regulation of cell fate commitment (GO:0010454)	1.69601979
96	alditol phosphate metabolic process (GO:0052646)	1.69121759
97	long-chain fatty acid biosynthetic process (GO:0042759)	1.68770336
98	coronary vasculature morphogenesis (GO:0060977)	1.67382733
99	regulation of monocyte chemotaxis (GO:0090025)	1.61052727
100	regulation of cardioblast proliferation (GO:0003264)	1.60856440

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.72851453
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.53427873
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.61281465
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.92579742
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.22626847
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.04767020
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.4344613
8	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.99424879
9	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.90329403
10	EGR1_19032775_ChIP-ChIP_M12_Human	1.83984209
11	E2F1_20622854_ChIP-Seq_HELA_Human	1.82177426
12	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.80603439
13	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.79214925
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.70350018
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.69627735
16	ERG_20517297_ChIP-Seq_VCAP_Human	1.65346111
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.64063209
18	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.61818649
19	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.61629643
20	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.60977105
21	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.60977105
22	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.56698639
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.53214797
24	TP63_22573176_ChIP-Seq_HFKS_Human	1.49186590
25	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.46032290
26	RACK7_27058665_Chip-Seq_MCF-7_Human	1.44746696
27	BCL6_27268052_Chip-Seq_Bcells_Human	1.43287171
28	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.42755850
29	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.40283298
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.39332439
31	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.39232651
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.39132485
33	BCOR_27268052_Chip-Seq_Bcells_Human	1.39132254
34	ATF3_27146783_Chip-Seq_COLON_Human	1.37018936
35	LXR_22292898_ChIP-Seq_THP-1_Human	1.36495801
36	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.36220008
37	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32892862
38	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.31136458
39	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.25740179
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.22705998
41	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.22294988
42	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22088497
43	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20578048
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19578925
45	TP63_23658742_ChIP-Seq_EP156T_Human	1.19283747
46	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17524356
47	P68_20966046_ChIP-Seq_HELA_Human	1.16256963
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.16159150
49	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.15958004
50	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15107424
51	PHF8_20622854_ChIP-Seq_HELA_Human	1.14454543
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13624244
53	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.10216645
54	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.09072585
55	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.08462374
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.07841432
57	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06191166
58	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04764703
59	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.03467561
60	GATA4_25053715_ChIP-Seq_YYC3_Human	1.02588991
61	SMC4_20622854_ChIP-Seq_HELA_Human	1.01611408
62	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.01513605
63	KLF5_25053715_ChIP-Seq_YYC3_Human	1.01449320
64	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00732810
65	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00187891
66	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.00177022
67	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.99338372
68	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.97610080
69	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97539689
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96588723
71	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96426417
72	SPI1_20517297_ChIP-Seq_HL60_Human	0.95249941
73	RXR_22108803_ChIP-Seq_LS180_Human	0.93190133
74	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92301221
75	SOX2_21211035_ChIP-Seq_LN229_Human	0.91650117
76	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90986571
77	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90315611
78	ZNF263_19887448_ChIP-Seq_K562_Human	0.89801877
79	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.88706440
80	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87308240
81	SOX2_20726797_ChIP-Seq_SW620_Human	0.87046705
82	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.86200540
83	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.86029465
84	AR_21572438_ChIP-Seq_LNCaP_Human	0.85646134
85	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85512266
86	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.83829295
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.83297790
88	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.82403875
89	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.81911109
90	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80237817
91	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.75553943
92	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.75142624
93	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.74981936
94	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.73203852
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.73092079
96	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.71766530
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.70728020
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.70728020
99	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.70365555
100	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.70262441

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.91202402
2	MP0002098_abnormal_vibrissa_morphology	6.41384496
3	MP0002796_impaired_skin_barrier	6.29539331
4	MP0000647_abnormal_sebaceous_gland	5.88197537
5	MP0005275_abnormal_skin_tensile	5.49091348
6	MP0000383_abnormal_hair_follicle	4.74547345
7	MP0010234_abnormal_vibrissa_follicle	4.73446115
8	MP0010678_abnormal_skin_adnexa	4.14016526
9	MP0005501_abnormal_skin_physiology	3.91505755
10	MP0000377_abnormal_hair_follicle	3.89217338
11	MP0003705_abnormal_hypodermis_morpholog	3.54143340
12	MP0000427_abnormal_hair_cycle	3.41883045
13	MP0002254_reproductive_system_inflammat	2.87758761
14	MP0004381_abnormal_hair_follicle	2.87220115
15	MP0001216_abnormal_epidermal_layer	2.81921758
16	MP0004947_skin_inflammation	2.45944625
17	MP0010771_integument_phenotype	2.45642584
18	MP0002060_abnormal_skin_morphology	2.29687509
19	MP0003453_abnormal_keratinocyte_physiol	2.25169389
20	MP0000367_abnormal_coat/_hair	2.24939126
21	MP0001243_abnormal_dermal_layer	2.07384375
22	MP0000467_abnormal_esophagus_morphology	2.06654998
23	MP0002234_abnormal_pharynx_morphology	1.85672255
24	MP0005409_darkened_coat_color	1.78803874
25	MP0000762_abnormal_tongue_morphology	1.60168897
26	MP0009931_abnormal_skin_appearance	1.55849042
27	MP0003566_abnormal_cell_adhesion	1.44610105
28	MP0009053_abnormal_anal_canal	1.40247088
29	MP0003941_abnormal_skin_development	1.39481688
30	MP0001191_abnormal_skin_condition	1.10047342
31	MP0002095_abnormal_skin_pigmentation	1.02429799
32	MP0008438_abnormal_cutaneous_collagen	1.00091194
33	MP0004185_abnormal_adipocyte_glucose	0.92673134
34	MP0004885_abnormal_endolymph	0.87348405
35	MP0004264_abnormal_extraembryonic_tissu	0.82659743
36	MP0001851_eye_inflammation	0.80656442
37	MP0001661_extended_life_span	0.76147919
38	MP0009379_abnormal_foot_pigmentation	0.73041766
39	MP0005451_abnormal_body_composition	0.71424677
40	MP0001849_ear_inflammation	0.69431798
41	MP0001346_abnormal_lacrimal_gland	0.67487232
42	MP0000566_synostosis	0.66029013
43	MP0001340_abnormal_eyelid_morphology	0.65328448
44	MP0003191_abnormal_cellular_cholesterol	0.64002268
45	MP0002282_abnormal_trachea_morphology	0.61442138
46	MP0003315_abnormal_perineum_morphology	0.60464338
47	MP0010030_abnormal_orbit_morphology	0.60400540
48	MP0002877_abnormal_melanocyte_morpholog	0.56637523
49	MP0005023_abnormal_wound_healing	0.53276927
50	MP0000627_abnormal_mammary_gland	0.51952973
51	MP0003755_abnormal_palate_morphology	0.51795537
52	MP0001784_abnormal_fluid_regulation	0.50177281
53	MP0002177_abnormal_outer_ear	0.42295094
54	MP0002970_abnormal_white_adipose	0.39840513
55	MP0005075_abnormal_melanosome_morpholog	0.38082751
56	MP0002111_abnormal_tail_morphology	0.37747879
57	MP0001188_hyperpigmentation	0.37548606
58	MP0010352_gastrointestinal_tract_polyps	0.34148061
59	MP0004272_abnormal_basement_membrane	0.32666248
60	MP0002249_abnormal_larynx_morphology	0.31659999
61	MP0003385_abnormal_body_wall	0.28830643
62	MP0002697_abnormal_eye_size	0.28317518
63	MP0000465_gastrointestinal_hemorrhage	0.27795264
64	MP0000537_abnormal_urethra_morphology	0.26469844
65	MP0003950_abnormal_plasma_membrane	0.24498065
66	MP0005248_abnormal_Harderian_gland	0.23341046
67	MP0000678_abnormal_parathyroid_gland	0.23296150
68	MP0002166_altered_tumor_susceptibility	0.22821721
69	MP0006054_spinal_hemorrhage	0.22121165
70	MP0002006_tumorigenesis	0.21736721
71	MP0000432_abnormal_head_morphology	0.21416512
72	MP0003763_abnormal_thymus_physiology	0.21022926
73	MP0009840_abnormal_foam_cell	0.19758248
74	MP0003300_gastrointestinal_ulcer	0.19490760
75	MP0003329_amyloid_beta_deposits	0.17331402
76	MP0005666_abnormal_adipose_tissue	0.16010840
77	MP0004019_abnormal_vitamin_homeostasis	0.14146291
78	MP0001958_emphysema	0.13870588
79	MP0005193_abnormal_anterior_eye	0.13842771
80	MP0003935_abnormal_craniofacial_develop	0.13832156
81	MP0002009_preneoplasia	0.13296197
82	MP0003448_altered_tumor_morphology	0.13161450
83	MP0003011_delayed_dark_adaptation	0.12719834
84	MP0009384_cardiac_valve_regurgitation	0.12566732
85	MP0005375_adipose_tissue_phenotype	0.12344576
86	MP0001879_abnormal_lymphatic_vessel	0.12253415
87	MP0005076_abnormal_cell_differentiation	0.11803526
88	MP0002233_abnormal_nose_morphology	0.11285098
89	MP0004742_abnormal_vestibular_system	0.10715109
90	MP0005257_abnormal_intraocular_pressure	0.10291739
91	MP0000462_abnormal_digestive_system	0.09068244
92	MP0000516_abnormal_urinary_system	0.08720564
93	MP0005367_renal/urinary_system_phenotyp	0.08720564
94	MP0000604_amyloidosis	0.08528007
95	MP0002090_abnormal_vision	0.07706351
96	MP0003638_abnormal_response/metabolism_	0.07100044
97	MP0005508_abnormal_skeleton_morphology	0.06896437
98	MP0000428_abnormal_craniofacial_morphol	0.06766963
99	MP0003045_fibrosis	0.06731218
100	MP0004858_abnormal_nervous_system	0.06109922

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Brittle hair (HP:0002299)	9.68247258
2	Pili torti (HP:0003777)	8.92726117
3	Abnormality of nail color (HP:0100643)	7.71058654
4	Nail dystrophy (HP:0008404)	7.14193945
5	Alopecia of scalp (HP:0002293)	5.76603434
6	Fragile nails (HP:0001808)	5.70776297
7	Abnormal hair laboratory examination (HP:0003328)	5.64502979
8	Palmoplantar hyperkeratosis (HP:0000972)	5.58926140
9	Thick nail (HP:0001805)	5.58517057
10	Follicular hyperkeratosis (HP:0007502)	5.36788078
11	Palmar hyperkeratosis (HP:0010765)	5.27478787
12	Increased IgE level (HP:0003212)	5.20287642
13	Plantar hyperkeratosis (HP:0007556)	5.06708595
14	Onycholysis (HP:0001806)	4.96219599
15	Fine hair (HP:0002213)	4.90819698
16	Right ventricular cardiomyopathy (HP:0011663)	4.16722823
17	Oral leukoplakia (HP:0002745)	4.03418029
18	Erythema (HP:0010783)	3.97865381
19	Milia (HP:0001056)	3.65434171
20	Sparse eyelashes (HP:0000653)	3.58149385
21	Erythroderma (HP:0001019)	3.33644200
22	Ridged nail (HP:0001807)	2.99769339
23	Abnormal blistering of the skin (HP:0008066)	2.93049534
24	Congenital ichthyosiform erythroderma (HP:0007431)	2.89909681
25	Amelogenesis imperfecta (HP:0000705)	2.84863484
26	Parakeratosis (HP:0001036)	2.84280572
27	Abnormality of the frontal sinuses (HP:0002687)	2.83569049
28	Congenital, generalized hypertrichosis (HP:0004540)	2.80203407
29	Curly hair (HP:0002212)	2.62852479
30	Natal tooth (HP:0000695)	2.42861167
31	Intention tremor (HP:0002080)	2.42269946
32	Conjunctival hamartoma (HP:0100780)	2.39316767
33	Advanced eruption of teeth (HP:0006288)	2.35166474
34	Aplasia cutis congenita (HP:0001057)	2.31873490
35	Palmoplantar keratoderma (HP:0000982)	2.29811518
36	Dry hair (HP:0011359)	2.26740524
37	Hypohidrosis (HP:0000966)	2.26347764
38	Corneal erosion (HP:0200020)	2.20776136
39	Neck muscle weakness (HP:0000467)	2.12300257
40	Torticollis (HP:0000473)	2.07110921
41	Pruritus (HP:0000989)	2.00985364
42	Hypotrichosis (HP:0001006)	14.0206201
43	Woolly hair (HP:0002224)	10.5701583
44	Abnormality of hair growth rate (HP:0011363)	10.2880973
45	Slow-growing hair (HP:0002217)	10.2880973
46	Ventricular tachycardia (HP:0004756)	1.99971028
47	Fatigable weakness (HP:0003473)	1.99812525
48	Abnormality of the neuromuscular junction (HP:0003398)	1.99812525
49	Ventricular fibrillation (HP:0001663)	1.73760036
50	Craniofacial dystonia (HP:0012179)	1.72718966
51	Gangrene (HP:0100758)	1.70505264
52	Laryngomalacia (HP:0001601)	1.70417363
53	Absent eyelashes (HP:0000561)	1.66932961
54	Concave nail (HP:0001598)	1.65964359
55	Difficulty walking (HP:0002355)	1.65914394
56	Abnormality of the pupil (HP:0000615)	1.65627765
57	Blepharitis (HP:0000498)	1.65258055
58	Anonychia (HP:0001798)	1.64170306
59	Abnormality of the parietal bone (HP:0002696)	1.61610558
60	Carious teeth (HP:0000670)	1.59416758
61	Recurrent corneal erosions (HP:0000495)	1.58245747
62	Abnormality of molar (HP:0011077)	1.57441874
63	Abnormality of molar morphology (HP:0011070)	1.57441874
64	Focal dystonia (HP:0004373)	1.57144003
65	Abnormality of permanent molar morphology (HP:0011071)	1.56774802
66	Abnormality of the dental root (HP:0006486)	1.56774802
67	Taurodontia (HP:0000679)	1.56774802
68	Ectropion (HP:0000656)	1.56437434
69	Atrophic scars (HP:0001075)	1.55654490
70	Hypergammaglobulinemia (HP:0010702)	1.53086131
71	Abnormality of dental color (HP:0011073)	1.51984988
72	Hamartoma of the eye (HP:0010568)	1.51525020
73	Widely patent fontanelles and sutures (HP:0004492)	1.51277208
74	Lip pit (HP:0100267)	1.48677373
75	Hyporeflexia of lower limbs (HP:0002600)	1.47159226
76	Corneal dystrophy (HP:0001131)	1.45241100
77	Amniotic constriction ring (HP:0009775)	1.44980405
78	Abnormality of placental membranes (HP:0011409)	1.44980405
79	Abnormality of the fingernails (HP:0001231)	1.44057409
80	Acanthosis nigricans (HP:0000956)	1.43283707
81	Keratoconjunctivitis sicca (HP:0001097)	1.43012208
82	Hyperhidrosis (HP:0000975)	1.41199796
83	Unilateral renal agenesis (HP:0000122)	1.39196385
84	Abnormality of the dental pulp (HP:0006479)	1.37225141
85	Neonatal onset (HP:0003623)	1.37014302
86	Sudden death (HP:0001699)	1.36779352
87	Heterogeneous (HP:0001425)	1.35779260
88	Abnormality of the aortic arch (HP:0012303)	1.32777895
89	Autoamputation (HP:0001218)	1.29880081
90	Achilles tendon contracture (HP:0001771)	1.26657764
91	Lack of skin elasticity (HP:0100679)	1.26457740
92	Sparse scalp hair (HP:0002209)	1.26046432
93	Keratoconjunctivitis (HP:0001096)	1.25890316
94	Craniofacial hyperostosis (HP:0004493)	1.23999047
95	Increased connective tissue (HP:0009025)	1.23588686
96	Distal lower limb muscle weakness (HP:0009053)	1.21968135
97	Type 1 muscle fiber predominance (HP:0003803)	1.21208679
98	Skin ulcer (HP:0200042)	1.20040749
99	Eczematoid dermatitis (HP:0000976)	1.19445917
100	Verrucae (HP:0200043)	1.18989903

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.34941910
2	EPHA2	4.02981570
3	ERN1	3.86605711
4	MAPKAPK3	3.86111252
5	MAP3K6	3.54309194
6	EPHB2	3.12706344
7	TAOK1	2.94730606
8	MAP3K3	2.83902228
9	LATS1	2.73256360
10	TRIB3	2.66432295
11	MAP3K2	2.47819447
12	MAP3K11	2.00644859
13	FGFR1	1.92021952
14	RPS6KB2	1.88785101
15	EEF2K	1.75609319
16	FGFR2	1.71909333
17	TTN	1.70233161
18	EPHB1	1.68455714
19	MAP2K6	1.67899643
20	PIK3CG	1.67868027
21	MST1R	1.62396200
22	LATS2	1.57489221
23	BCR	1.51069159
24	FGFR4	1.46232355
25	FGFR3	1.41914479
26	RIPK1	1.29807082
27	BLK	1.24810749
28	MAP3K1	1.24073590
29	CDK6	1.23744167
30	PDGFRA	1.20746263
31	BMX	1.18763734
32	MAP2K3	1.12842193
33	MAPKAPK2	1.11695323
34	NME1	1.10289826
35	PKN2	1.06958896
36	PTK6	1.06370028
37	KSR2	1.05791388
38	MAP3K9	1.03695794
39	RPS6KA4	1.02562189
40	MAP3K7	0.98029919
41	PBK	0.97282504
42	LRRK2	0.96793657
43	SIK1	0.88072183
44	MET	0.85359932
45	PTK2	0.82906905
46	MAP2K4	0.82763459
47	MAP2K1	0.73583184
48	STK38	0.69751351
49	EPHA3	0.69442285
50	DDR2	0.69149394
51	TYK2	0.67789282
52	TRPM7	0.66524443
53	STK38L	0.66333040
54	NTRK2	0.65874573
55	TESK1	0.64500424
56	DYRK1B	0.64148722
57	PRKD1	0.63773195
58	ERBB4	0.62047378
59	JAK1	0.61892107
60	PAK4	0.61758019
61	PIM2	0.60247969
62	PAK3	0.59601737
63	TYRO3	0.55583708
64	MAP3K5	0.54338346
65	OBSCN	0.53295176
66	PRKCH	0.53266695
67	PAK2	0.51046395
68	ERBB2	0.50940994
69	RET	0.50299115
70	MAP3K10	0.49125772
71	PRKCI	0.48069336
72	CDK19	0.46742000
73	RPS6KA1	0.46073411
74	TGFBR2	0.46000571
75	MST4	0.43536572
76	TGFBR1	0.40998651
77	GSK3A	0.40479612
78	NEK1	0.39384373
79	CSNK1E	0.39222863
80	ALK	0.38474456
81	PAK6	0.38452667
82	MAPK12	0.37983979
83	ERBB3	0.34210169
84	JAK2	0.33960838
85	FYN	0.32054549
86	STK24	0.30821769
87	SRC	0.26898245
88	CLK1	0.26778116
89	CSNK1A1	0.26648178
90	STK3	0.26344076
91	MAP2K2	0.25639725
92	PDGFRB	0.24809096
93	LIMK1	0.24775803
94	HCK	0.24662403
95	MAP3K8	0.24362004
96	ILK	0.23542147
97	STK11	0.23304093
98	CSNK1A1L	0.23271804
99	CSNK1G1	0.23121889
100	MTOR	0.22498864

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.79179873
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.73460200
3	Fatty acid elongation_Homo sapiens_hsa00062	3.23067484
4	Fat digestion and absorption_Homo sapiens_hsa04975	2.99192967
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.52897074
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.14555367
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.91850368
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.84775633
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.82275031
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.75511052
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.67843036
12	Melanogenesis_Homo sapiens_hsa04916	1.54753648
13	Axon guidance_Homo sapiens_hsa04360	1.48110261
14	Caffeine metabolism_Homo sapiens_hsa00232	1.44284226
15	Glioma_Homo sapiens_hsa05214	1.37243063
16	Histidine metabolism_Homo sapiens_hsa00340	1.35983650
17	Proteoglycans in cancer_Homo sapiens_hsa05205	1.31768348
18	Bladder cancer_Homo sapiens_hsa05219	1.31255260
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.31165020
20	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.29061803
21	Thyroid cancer_Homo sapiens_hsa05216	1.27166596
22	GnRH signaling pathway_Homo sapiens_hsa04912	1.27082868
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.27023049
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.25271675
25	ECM-receptor interaction_Homo sapiens_hsa04512	1.24023601
26	Acute myeloid leukemia_Homo sapiens_hsa05221	1.20566118
27	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.17552715
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.13863328
29	Mineral absorption_Homo sapiens_hsa04978	1.07492343
30	Tight junction_Homo sapiens_hsa04530	1.07246336
31	Adherens junction_Homo sapiens_hsa04520	1.05728860
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04969159
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.04303164
34	Pancreatic secretion_Homo sapiens_hsa04972	1.03278264
35	Long-term potentiation_Homo sapiens_hsa04720	0.99240705
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.98228589
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.96771846
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.95010730
39	Pertussis_Homo sapiens_hsa05133	0.93644831
40	Amoebiasis_Homo sapiens_hsa05146	0.88062591
41	Endometrial cancer_Homo sapiens_hsa05213	0.87919054
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.86998677
43	Non-small cell lung cancer_Homo sapiens_hsa05223	0.86170641
44	Long-term depression_Homo sapiens_hsa04730	0.84542038
45	Ras signaling pathway_Homo sapiens_hsa04014	0.83958532
46	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82964785
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.82746388
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82204609
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.80938874
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.79313511
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.76766156
52	Phototransduction_Homo sapiens_hsa04744	0.74218247
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73969981
54	Protein digestion and absorption_Homo sapiens_hsa04974	0.72525644
55	MicroRNAs in cancer_Homo sapiens_hsa05206	0.71373136
56	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.70324598
57	Renin secretion_Homo sapiens_hsa04924	0.69740340
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.69611919
59	Gastric acid secretion_Homo sapiens_hsa04971	0.66353047
60	Hepatitis C_Homo sapiens_hsa05160	0.63676086
61	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.63254007
62	Focal adhesion_Homo sapiens_hsa04510	0.63092868
63	Insulin resistance_Homo sapiens_hsa04931	0.60318877
64	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.59576910
65	Platelet activation_Homo sapiens_hsa04611	0.59040548
66	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.58224266
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57046453
68	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56744372
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.55410100
70	Salmonella infection_Homo sapiens_hsa05132	0.55194438
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54994724
72	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53945630
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.53841456
74	Toxoplasmosis_Homo sapiens_hsa05145	0.50903297
75	Gap junction_Homo sapiens_hsa04540	0.49922769
76	Renal cell carcinoma_Homo sapiens_hsa05211	0.47719501
77	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.47631446
78	Salivary secretion_Homo sapiens_hsa04970	0.47322080
79	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.47317478
80	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46588169
81	p53 signaling pathway_Homo sapiens_hsa04115	0.45416898
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45062169
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.44972764
84	Tuberculosis_Homo sapiens_hsa05152	0.44919382
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43194424
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.43166234
87	Notch signaling pathway_Homo sapiens_hsa04330	0.41709445
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41638699
89	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.39495437
90	Olfactory transduction_Homo sapiens_hsa04740	0.37523814
91	Fatty acid degradation_Homo sapiens_hsa00071	0.37272355
92	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36951510
93	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.34728827
94	Melanoma_Homo sapiens_hsa05218	0.34416317
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.34247370
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.33366435
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.33286273
98	Pathways in cancer_Homo sapiens_hsa05200	0.33169415
99	Butanoate metabolism_Homo sapiens_hsa00650	0.33058516
100	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.32860509

KRTAP21-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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