ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	9.67551983
2	virion attachment to host cell (GO:0019062)	9.67551983
3	citrulline biosynthetic process (GO:0019240)	8.75656758
4	peptide cross-linking (GO:0018149)	8.51374911
5	hair follicle morphogenesis (GO:0031069)	8.25776070
6	adhesion of symbiont to host (GO:0044406)	8.13868150
7	intermediate filament cytoskeleton organization (GO:0045104)	6.73206195
8	intermediate filament-based process (GO:0045103)	6.51539242
9	cell wall macromolecule catabolic process (GO:0016998)	6.34766929
10	cell wall macromolecule metabolic process (GO:0044036)	6.34766929
11	epidermis development (GO:0008544)	6.29380074
12	establishment of skin barrier (GO:0061436)	5.92527438
13	keratinocyte differentiation (GO:0030216)	5.87580298
14	citrulline metabolic process (GO:0000052)	5.78058201
15	hair cycle process (GO:0022405)	5.35847304
16	molting cycle process (GO:0022404)	5.35847304
17	regulation of water loss via skin (GO:0033561)	5.27103034
18	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.01405594
19	peptidyl-arginine modification (GO:0018195)	4.83609670
20	hemidesmosome assembly (GO:0031581)	4.82990871
21	skin morphogenesis (GO:0043589)	4.71619873
22	epidermal cell differentiation (GO:0009913)	4.58672755
23	molting cycle (GO:0042303)	34.1872150
24	hair cycle (GO:0042633)	34.1872150
25	keratinocyte development (GO:0003334)	3.93740302
26	tooth mineralization (GO:0034505)	3.88193265
27	multicellular organismal water homeostasis (GO:0050891)	3.53573422
28	regulation of keratinocyte differentiation (GO:0045616)	3.47718378
29	negative regulation of keratinocyte proliferation (GO:0010839)	3.38259189
30	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.35176958
31	positive regulation of hair cycle (GO:0042635)	3.25712580
32	positive regulation of hair follicle development (GO:0051798)	3.25712580
33	hair follicle development (GO:0001942)	3.21904734
34	bone trabecula formation (GO:0060346)	3.09357714
35	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.07815084
36	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.05593527
37	regulation of hair follicle development (GO:0051797)	3.02195960
38	epithelium development (GO:0060429)	2.98456266
39	gap junction assembly (GO:0016264)	2.96672363
40	positive regulation of meiotic cell cycle (GO:0051446)	2.93790468
41	water homeostasis (GO:0030104)	2.90199510
42	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.81711694
43	regulation of hair cycle (GO:0042634)	2.78525549
44	fatty acid elongation (GO:0030497)	2.76495710
45	positive regulation of epidermis development (GO:0045684)	2.71362211
46	regulation of epidermal cell differentiation (GO:0045604)	2.67745154
47	ectoderm development (GO:0007398)	2.63717325
48	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.55975321
49	negative regulation of protein localization to plasma membrane (GO:1903077)	2.54967188
50	regulation of epidermis development (GO:0045682)	2.53648541
51	atrioventricular valve morphogenesis (GO:0003181)	2.49120860
52	positive regulation of monocyte chemotaxis (GO:0090026)	2.39271449
53	wound healing, spreading of epidermal cells (GO:0035313)	2.32269421
54	phosphatidylserine metabolic process (GO:0006658)	2.31959012
55	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.30000466
56	cranial suture morphogenesis (GO:0060363)	2.29828259
57	ventricular cardiac muscle cell action potential (GO:0086005)	2.29609592
58	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.24495170
59	positive regulation of epidermal cell differentiation (GO:0045606)	2.23692723
60	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.20731907
61	negative regulation of cell fate specification (GO:0009996)	2.20541077
62	regulation of ruffle assembly (GO:1900027)	2.16873414
63	skin development (GO:0043588)	2.12969688
64	lymph vessel development (GO:0001945)	2.09042820
65	negative regulation of epidermis development (GO:0045683)	2.08039498
66	keratinization (GO:0031424)	12.1095231
67	intermediate filament organization (GO:0045109)	12.0652419
68	desmosome organization (GO:0002934)	10.3420541
69	aging (GO:0007568)	1.99870112
70	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.98074843
71	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.97815328
72	myotube differentiation (GO:0014902)	1.97663646
73	epithelial cell-cell adhesion (GO:0090136)	1.97038114
74	ephrin receptor signaling pathway (GO:0048013)	1.96464993
75	outflow tract septum morphogenesis (GO:0003148)	1.94895183
76	regulation of cardioblast differentiation (GO:0051890)	1.94254859
77	regulation of heart rate by cardiac conduction (GO:0086091)	1.92478706
78	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.92362550
79	regulation of keratinocyte proliferation (GO:0010837)	1.89970935
80	cell communication involved in cardiac conduction (GO:0086065)	1.86565831
81	non-canonical Wnt signaling pathway (GO:0035567)	1.85174451
82	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.82204325
83	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.79867679
84	cell-substrate junction assembly (GO:0007044)	1.77502334
85	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.76593402
86	negative regulation of epidermal cell differentiation (GO:0045605)	1.72813676
87	very long-chain fatty acid metabolic process (GO:0000038)	1.72417869
88	primary alcohol catabolic process (GO:0034310)	1.72323919
89	keratinocyte proliferation (GO:0043616)	1.72224652
90	regulation of monocyte chemotaxis (GO:0090025)	1.71157226
91	alditol phosphate metabolic process (GO:0052646)	1.70569842
92	establishment of tissue polarity (GO:0007164)	1.66445088
93	establishment of planar polarity (GO:0001736)	1.66445088
94	craniofacial suture morphogenesis (GO:0097094)	1.65054847
95	cardiac right ventricle morphogenesis (GO:0003215)	1.62889281
96	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.62389643
97	wound healing, spreading of cells (GO:0044319)	1.62184396
98	eyelid development in camera-type eye (GO:0061029)	1.60682432
99	negative regulation of Ras GTPase activity (GO:0034261)	1.58911895
100	response to UV-B (GO:0010224)	1.58309321

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.25755422
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.08623510
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.61278216
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.79173676
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.35382496
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.05623856
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.04445501
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.6673104
9	E2F1_20622854_ChIP-Seq_HELA_Human	1.80848985
10	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.80452417
11	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.74926679
12	EGR1_19032775_ChIP-ChIP_M12_Human	1.72034638
13	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.71779395
14	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.71647595
15	ERG_20517297_ChIP-Seq_VCAP_Human	1.69644974
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.68528762
17	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.65093766
18	P53_21459846_ChIP-Seq_SAOS-2_Human	1.61514424
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.61101085
20	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.59078775
21	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.56245130
22	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.55506581
23	BCL6_27268052_Chip-Seq_Bcells_Human	1.51928727
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51786171
25	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.49615428
26	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.49085174
27	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.49085174
28	TP63_22573176_ChIP-Seq_HFKS_Human	1.49028333
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.46848250
30	LXR_22292898_ChIP-Seq_THP-1_Human	1.46259739
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.43246737
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40777123
33	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.39904732
34	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.39081790
35	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.37177083
36	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36488945
37	ATF3_27146783_Chip-Seq_COLON_Human	1.33530325
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.29600545
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27747952
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.27316457
41	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.26563875
42	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.26003018
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24985359
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24296077
45	AHR_22903824_ChIP-Seq_MCF-7_Human	1.23440652
46	P68_20966046_ChIP-Seq_HELA_Human	1.22222391
47	CEBPB_22108803_ChIP-Seq_LS180_Human	1.21206809
48	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.20529082
49	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19701430
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.19698004
51	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.16305121
52	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15595135
53	TP63_23658742_ChIP-Seq_EP156T_Human	1.14630432
54	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10793949
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.10605775
56	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09297139
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.08915918
58	* PHF8_20622854_ChIP-Seq_HELA_Human	1.08140164
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.07003722
60	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.06697344
61	SOX2_21211035_ChIP-Seq_LN229_Human	1.05783496
62	GATA4_25053715_ChIP-Seq_YYC3_Human	1.05709388
63	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.05506895
64	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05047088
65	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04367350
66	SMC4_20622854_ChIP-Seq_HELA_Human	1.04260374
67	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.03341936
68	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02748824
69	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.01756294
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99909967
71	SPI1_20517297_ChIP-Seq_HL60_Human	0.98772117
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97234279
73	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.96749783
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94565908
75	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94515332
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93458703
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91747783
78	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.90778262
79	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.90509676
80	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.90269692
81	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.89787928
82	RXR_22108803_ChIP-Seq_LS180_Human	0.89367126
83	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.88676363
84	ZNF263_19887448_ChIP-Seq_K562_Human	0.88400554
85	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.88175332
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86767579
87	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.84862910
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.84456679
89	AR_21572438_ChIP-Seq_LNCaP_Human	0.82006821
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.81739196
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.80011890
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.79546624
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77663976
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.74741699
95	CLOCK_20551151_ChIP-Seq_293T_Human	0.74618264
96	* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.73862389
97	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.73622463
98	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.73557911
99	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.73048802
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.72756225

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.44906806
2	MP0002098_abnormal_vibrissa_morphology	7.15770953
3	MP0000647_abnormal_sebaceous_gland	6.38705994
4	MP0002796_impaired_skin_barrier	6.04504714
5	MP0005275_abnormal_skin_tensile	5.19411947
6	MP0010234_abnormal_vibrissa_follicle	5.11852641
7	MP0000383_abnormal_hair_follicle	4.55826490
8	MP0010678_abnormal_skin_adnexa	4.05158849
9	MP0000377_abnormal_hair_follicle	4.02701448
10	MP0005501_abnormal_skin_physiology	3.75737542
11	MP0003705_abnormal_hypodermis_morpholog	3.69223717
12	MP0000427_abnormal_hair_cycle	3.45238224
13	MP0002254_reproductive_system_inflammat	3.25516871
14	MP0001216_abnormal_epidermal_layer	2.70335216
15	MP0004381_abnormal_hair_follicle	2.41499138
16	MP0000367_abnormal_coat/_hair	2.38005087
17	MP0010771_integument_phenotype	2.36104539
18	MP0004947_skin_inflammation	2.28059485
19	MP0002060_abnormal_skin_morphology	2.25751663
20	MP0003453_abnormal_keratinocyte_physiol	2.19024249
21	MP0001243_abnormal_dermal_layer	2.15016679
22	MP0002234_abnormal_pharynx_morphology	1.97243106
23	MP0000467_abnormal_esophagus_morphology	1.72177475
24	MP0009931_abnormal_skin_appearance	1.53422636
25	MP0009053_abnormal_anal_canal	1.52999635
26	MP0000762_abnormal_tongue_morphology	1.48797058
27	MP0003566_abnormal_cell_adhesion	1.44380535
28	MP0003941_abnormal_skin_development	1.31802389
29	MP0005409_darkened_coat_color	1.14871291
30	MP0004885_abnormal_endolymph	1.03561458
31	MP0004185_abnormal_adipocyte_glucose	1.02421172
32	MP0001191_abnormal_skin_condition	1.01946448
33	MP0004264_abnormal_extraembryonic_tissu	0.94766253
34	MP0008438_abnormal_cutaneous_collagen	0.78726682
35	MP0002095_abnormal_skin_pigmentation	0.75022124
36	MP0001851_eye_inflammation	0.73983233
37	MP0001346_abnormal_lacrimal_gland	0.70330030
38	MP0003315_abnormal_perineum_morphology	0.68705522
39	MP0002877_abnormal_melanocyte_morpholog	0.68295815
40	MP0000566_synostosis	0.66047182
41	MP0001340_abnormal_eyelid_morphology	0.65380614
42	MP0010030_abnormal_orbit_morphology	0.63537416
43	MP0001849_ear_inflammation	0.61749345
44	MP0000627_abnormal_mammary_gland	0.57246327
45	MP0003191_abnormal_cellular_cholesterol	0.54627595
46	MP0001661_extended_life_span	0.54046467
47	MP0002282_abnormal_trachea_morphology	0.50914819
48	MP0005451_abnormal_body_composition	0.48877205
49	MP0005023_abnormal_wound_healing	0.48394244
50	MP0003755_abnormal_palate_morphology	0.48090717
51	MP0001784_abnormal_fluid_regulation	0.45703323
52	MP0002970_abnormal_white_adipose	0.44497428
53	MP0002111_abnormal_tail_morphology	0.41885754
54	MP0010352_gastrointestinal_tract_polyps	0.36747174
55	MP0002249_abnormal_larynx_morphology	0.35314021
56	MP0003385_abnormal_body_wall	0.33393662
57	MP0000537_abnormal_urethra_morphology	0.33258281
58	MP0004272_abnormal_basement_membrane	0.32310987
59	MP0002177_abnormal_outer_ear	0.29562804
60	MP0009379_abnormal_foot_pigmentation	0.29560219
61	MP0009840_abnormal_foam_cell	0.28725191
62	MP0005075_abnormal_melanosome_morpholog	0.26651905
63	MP0000678_abnormal_parathyroid_gland	0.25931391
64	MP0003329_amyloid_beta_deposits	0.25895867
65	MP0003763_abnormal_thymus_physiology	0.25012894
66	MP0003950_abnormal_plasma_membrane	0.24870248
67	MP0002697_abnormal_eye_size	0.23353666
68	MP0005248_abnormal_Harderian_gland	0.23090542
69	MP0000465_gastrointestinal_hemorrhage	0.23080460
70	MP0006054_spinal_hemorrhage	0.21317866
71	MP0005666_abnormal_adipose_tissue	0.19565847
72	MP0004019_abnormal_vitamin_homeostasis	0.18913502
73	MP0000432_abnormal_head_morphology	0.18657688
74	MP0003300_gastrointestinal_ulcer	0.18205491
75	MP0003638_abnormal_response/metabolism_	0.16981016
76	MP0003935_abnormal_craniofacial_develop	0.15567109
77	MP0005375_adipose_tissue_phenotype	0.14802667
78	MP0000604_amyloidosis	0.14741207
79	MP0004742_abnormal_vestibular_system	0.14269589
80	MP0003448_altered_tumor_morphology	0.14258509
81	MP0002166_altered_tumor_susceptibility	0.14072315
82	MP0000751_myopathy	0.13677561
83	MP0005367_renal/urinary_system_phenotyp	0.13365831
84	MP0000516_abnormal_urinary_system	0.13365831
85	MP0002006_tumorigenesis	0.12938262
86	MP0001879_abnormal_lymphatic_vessel	0.12687088
87	MP0003011_delayed_dark_adaptation	0.12535736
88	MP0004858_abnormal_nervous_system	0.12246450
89	MP0009384_cardiac_valve_regurgitation	0.11975642
90	MP0005076_abnormal_cell_differentiation	0.10680751
91	MP0003075_altered_response_to	0.10490294
92	MP0002233_abnormal_nose_morphology	0.08682653
93	MP0000750_abnormal_muscle_regeneration	0.07933503
94	MP0005193_abnormal_anterior_eye	0.07626175
95	MP0000733_abnormal_muscle_development	0.07191760
96	MP0001958_emphysema	0.07159097
97	MP0005508_abnormal_skeleton_morphology	0.06555091
98	MP0006138_congestive_heart_failure	0.06515433
99	MP0003045_fibrosis	0.06448561
100	MP0002009_preneoplasia	0.06285637

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.62592504
2	Nail dystrophy (HP:0008404)	7.43880970
3	Abnormality of nail color (HP:0100643)	6.04181178
4	Fragile nails (HP:0001808)	5.59052982
5	Abnormal hair laboratory examination (HP:0003328)	5.45357036
6	Fine hair (HP:0002213)	5.33448815
7	Alopecia of scalp (HP:0002293)	4.86041335
8	Palmoplantar hyperkeratosis (HP:0000972)	4.74170507
9	Onycholysis (HP:0001806)	4.49186085
10	Palmar hyperkeratosis (HP:0010765)	4.45893789
11	Plantar hyperkeratosis (HP:0007556)	4.31883093
12	Thick nail (HP:0001805)	4.25480204
13	Increased IgE level (HP:0003212)	4.19394676
14	Right ventricular cardiomyopathy (HP:0011663)	4.09261451
15	Follicular hyperkeratosis (HP:0007502)	4.02063641
16	Sparse eyelashes (HP:0000653)	3.48793426
17	Erythema (HP:0010783)	3.42473463
18	Oral leukoplakia (HP:0002745)	3.30822458
19	Parakeratosis (HP:0001036)	3.27240864
20	Abnormality of the frontal sinuses (HP:0002687)	3.23089914
21	Amelogenesis imperfecta (HP:0000705)	3.08520299
22	Milia (HP:0001056)	3.05145205
23	Erythroderma (HP:0001019)	3.03339285
24	Curly hair (HP:0002212)	2.71884328
25	Congenital ichthyosiform erythroderma (HP:0007431)	2.60449531
26	Ridged nail (HP:0001807)	2.59038543
27	Intention tremor (HP:0002080)	2.58332612
28	Congenital, generalized hypertrichosis (HP:0004540)	2.55368861
29	Aplasia cutis congenita (HP:0001057)	2.52185693
30	Neck muscle weakness (HP:0000467)	2.50134276
31	Dry hair (HP:0011359)	2.48823970
32	Abnormal blistering of the skin (HP:0008066)	2.31635106
33	Torticollis (HP:0000473)	2.28644805
34	Natal tooth (HP:0000695)	2.24313201
35	Advanced eruption of teeth (HP:0006288)	2.16044406
36	Corneal erosion (HP:0200020)	2.14975207
37	Hypohidrosis (HP:0000966)	2.13470274
38	Palmoplantar keratoderma (HP:0000982)	2.04999268
39	Hypotrichosis (HP:0001006)	15.0271212
40	Abnormality of hair growth rate (HP:0011363)	11.2799418
41	Slow-growing hair (HP:0002217)	11.2799418
42	Woolly hair (HP:0002224)	11.0614900
43	Brittle hair (HP:0002299)	10.4633367
44	Ventricular tachycardia (HP:0004756)	1.99070697
45	Concave nail (HP:0001598)	1.94370656
46	Craniofacial dystonia (HP:0012179)	1.93546448
47	Pruritus (HP:0000989)	1.89778982
48	Difficulty walking (HP:0002355)	1.84218728
49	Abnormality of the pupil (HP:0000615)	1.83354043
50	Abnormality of the parietal bone (HP:0002696)	1.83169757
51	Abnormality of dental color (HP:0011073)	1.81867492
52	Abnormality of the dental root (HP:0006486)	1.80376048
53	Taurodontia (HP:0000679)	1.80376048
54	Abnormality of permanent molar morphology (HP:0011071)	1.80376048
55	Hyporeflexia of lower limbs (HP:0002600)	1.77405252
56	Abnormality of molar (HP:0011077)	1.77107077
57	Abnormality of molar morphology (HP:0011070)	1.77107077
58	Focal dystonia (HP:0004373)	1.77087137
59	Conjunctival hamartoma (HP:0100780)	1.75574251
60	Widely patent fontanelles and sutures (HP:0004492)	1.75061602
61	Ventricular fibrillation (HP:0001663)	1.72006287
62	Absent eyelashes (HP:0000561)	1.70309509
63	Recurrent corneal erosions (HP:0000495)	1.68428911
64	Abnormality of the dental pulp (HP:0006479)	1.57550176
65	Amniotic constriction ring (HP:0009775)	1.56608427
66	Abnormality of placental membranes (HP:0011409)	1.56608427
67	Blepharitis (HP:0000498)	1.53363296
68	Round ear (HP:0100830)	1.51828314
69	Fatigable weakness (HP:0003473)	1.51733247
70	Abnormality of the neuromuscular junction (HP:0003398)	1.51733247
71	Lip pit (HP:0100267)	1.51220746
72	Sudden death (HP:0001699)	1.48457797
73	Acanthosis nigricans (HP:0000956)	1.47838902
74	Distal lower limb muscle weakness (HP:0009053)	1.47525816
75	Keratoconjunctivitis sicca (HP:0001097)	1.45999098
76	Heterogeneous (HP:0001425)	1.42877680
77	Achilles tendon contracture (HP:0001771)	1.41624158
78	Unilateral renal agenesis (HP:0000122)	1.39671027
79	Autoamputation (HP:0001218)	1.37976261
80	Gangrene (HP:0100758)	1.37119727
81	Carious teeth (HP:0000670)	1.36474195
82	Craniofacial hyperostosis (HP:0004493)	1.34617433
83	Abnormality of the aortic arch (HP:0012303)	1.34352445
84	Ectropion (HP:0000656)	1.34172385
85	Abnormality of the Achilles tendon (HP:0005109)	1.33702582
86	Keratoconjunctivitis (HP:0001096)	1.28440953
87	Type 1 muscle fiber predominance (HP:0003803)	1.27710758
88	Anonychia (HP:0001798)	1.26194488
89	Abnormality of the fingernails (HP:0001231)	1.25265119
90	Variable expressivity (HP:0003828)	1.21408065
91	Increased connective tissue (HP:0009025)	1.20995827
92	Lack of skin elasticity (HP:0100679)	1.20872140
93	Neonatal onset (HP:0003623)	1.20143834
94	Hypergammaglobulinemia (HP:0010702)	1.19712904
95	Widely spaced teeth (HP:0000687)	1.17817919
96	Atrophic scars (HP:0001075)	1.17577776
97	Distal arthrogryposis (HP:0005684)	1.16995565
98	Selective tooth agenesis (HP:0001592)	1.12579579
99	Bronchomalacia (HP:0002780)	1.12558935
100	Sparse scalp hair (HP:0002209)	1.11623232

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.34798451
2	MAPKAPK3	4.20107165
3	FER	3.81361358
4	ERN1	3.80955000
5	MAP3K6	3.26714107
6	EPHB2	3.17587402
7	TAOK1	2.92694353
8	MAP3K3	2.79962045
9	TRIB3	2.56437508
10	LATS1	2.53483665
11	MAP3K2	2.47547218
12	PIK3CG	2.12588571
13	TTN	2.10054915
14	MAP3K11	2.03694477
15	RPS6KB2	2.02527380
16	MAP2K6	1.89646572
17	LATS2	1.69214168
18	EEF2K	1.58981769
19	FGFR2	1.53213826
20	EPHB1	1.50810417
21	NME1	1.45654021
22	MST1R	1.43786476
23	BCR	1.42896015
24	KSR2	1.34100668
25	MAP3K1	1.31342898
26	MAP2K3	1.22551677
27	CDK6	1.19212203
28	RIPK1	1.18724520
29	PBK	1.15578952
30	FGFR4	1.13591284
31	FGFR1	1.12617111
32	BMX	1.11478571
33	LRRK2	1.10186648
34	BLK	1.06436730
35	PKN2	1.05722973
36	MAPKAPK2	1.04129268
37	FGFR3	1.03375238
38	PDGFRA	1.01352403
39	MAP3K7	0.97977198
40	PTK6	0.95991981
41	MAP2K4	0.92613981
42	MAP3K9	0.91010108
43	MAP2K1	0.82112992
44	PIM2	0.79761685
45	RPS6KA4	0.76976935
46	STK38	0.76801251
47	MET	0.74157957
48	STK38L	0.72842212
49	PTK2	0.72471414
50	DYRK1B	0.72288380
51	CDK19	0.72143109
52	DDR2	0.71641842
53	PRKD1	0.71381908
54	TESK1	0.71241090
55	PAK3	0.71183204
56	SIK1	0.69269921
57	OBSCN	0.67442006
58	PAK4	0.65633782
59	ERBB4	0.64025201
60	NTRK2	0.60479411
61	MAP3K5	0.58285293
62	NEK1	0.57751645
63	TRPM7	0.56954184
64	PRKCI	0.56624421
65	TGFBR1	0.55525081
66	ERBB3	0.55477071
67	MST4	0.55049097
68	TYRO3	0.54958120
69	PRKCH	0.52351231
70	ALK	0.50864405
71	RET	0.49824159
72	PAK6	0.48487229
73	ERBB2	0.46664866
74	MAPK12	0.46360623
75	ILK	0.43018754
76	PHKG2	0.42515240
77	PHKG1	0.42515240
78	GSK3A	0.42474768
79	CSNK1E	0.41952150
80	JAK1	0.41525141
81	PAK2	0.41250583
82	LIMK1	0.39965534
83	MAP2K2	0.39771127
84	RPS6KA1	0.39589289
85	JAK2	0.38048300
86	MAP3K10	0.36672642
87	EPHA3	0.34139332
88	TYK2	0.32286150
89	FYN	0.27447140
90	ROCK2	0.27033450
91	MAP3K8	0.26253307
92	SRC	0.25041042
93	CSNK1A1	0.24737061
94	MARK3	0.24586991
95	STK24	0.23363689
96	CSNK1D	0.23325705
97	CSNK1A1L	0.23201395
98	PRKACG	0.22636438
99	PRKACA	0.22295387
100	GRK6	0.22098268

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.68141492
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.65656045
3	Fat digestion and absorption_Homo sapiens_hsa04975	2.92491903
4	Fatty acid elongation_Homo sapiens_hsa00062	2.83221073
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.46828075
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.17714751
7	Phenylalanine metabolism_Homo sapiens_hsa00360	1.85325056
8	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.81517460
9	VEGF signaling pathway_Homo sapiens_hsa04370	1.78534767
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.72830009
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.72307855
12	Melanogenesis_Homo sapiens_hsa04916	1.60920684
13	Axon guidance_Homo sapiens_hsa04360	1.55671726
14	Histidine metabolism_Homo sapiens_hsa00340	1.43135511
15	Bladder cancer_Homo sapiens_hsa05219	1.39564402
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36651258
17	Glioma_Homo sapiens_hsa05214	1.35284443
18	Thyroid cancer_Homo sapiens_hsa05216	1.32913150
19	GnRH signaling pathway_Homo sapiens_hsa04912	1.31378103
20	Proteoglycans in cancer_Homo sapiens_hsa05205	1.29336674
21	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.29302486
22	Hippo signaling pathway_Homo sapiens_hsa04390	1.23792157
23	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.22810606
24	Caffeine metabolism_Homo sapiens_hsa00232	1.17556213
25	Tight junction_Homo sapiens_hsa04530	1.15612768
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.11108915
27	Long-term potentiation_Homo sapiens_hsa04720	1.10589776
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.09315167
29	Mineral absorption_Homo sapiens_hsa04978	1.07200501
30	Pancreatic secretion_Homo sapiens_hsa04972	1.06665657
31	Acute myeloid leukemia_Homo sapiens_hsa05221	1.06413388
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04925886
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04057235
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97679077
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.92758156
36	Long-term depression_Homo sapiens_hsa04730	0.92191692
37	Tyrosine metabolism_Homo sapiens_hsa00350	0.91491808
38	Adherens junction_Homo sapiens_hsa04520	0.91254684
39	Steroid biosynthesis_Homo sapiens_hsa00100	0.90235517
40	ECM-receptor interaction_Homo sapiens_hsa04512	0.89785134
41	Pertussis_Homo sapiens_hsa05133	0.89351406
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.87643163
43	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87627203
44	Endometrial cancer_Homo sapiens_hsa05213	0.84875105
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.84784417
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82649766
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82461581
48	Ras signaling pathway_Homo sapiens_hsa04014	0.82036668
49	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.81404557
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.79192515
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.77368409
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.75556929
53	Amoebiasis_Homo sapiens_hsa05146	0.72783034
54	Renin secretion_Homo sapiens_hsa04924	0.72393919
55	Gastric acid secretion_Homo sapiens_hsa04971	0.71448838
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.69229305
57	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.68130528
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.67415877
59	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67263822
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.66662780
61	MicroRNAs in cancer_Homo sapiens_hsa05206	0.62911102
62	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60231253
63	Phototransduction_Homo sapiens_hsa04744	0.58553547
64	Insulin resistance_Homo sapiens_hsa04931	0.58161984
65	Gap junction_Homo sapiens_hsa04540	0.57602223
66	Hepatitis C_Homo sapiens_hsa05160	0.55579990
67	Butanoate metabolism_Homo sapiens_hsa00650	0.55396880
68	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55143284
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54941157
70	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54657931
71	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54449046
72	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.53255759
73	Platelet activation_Homo sapiens_hsa04611	0.51820536
74	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51812529
75	Salmonella infection_Homo sapiens_hsa05132	0.51809366
76	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51035809
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.50968806
78	Fatty acid degradation_Homo sapiens_hsa00071	0.50837661
79	Focal adhesion_Homo sapiens_hsa04510	0.48240981
80	Salivary secretion_Homo sapiens_hsa04970	0.48032108
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47920956
82	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47751517
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47461683
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47423488
85	ErbB signaling pathway_Homo sapiens_hsa04012	0.46460682
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45971532
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.44710932
88	Protein digestion and absorption_Homo sapiens_hsa04974	0.44141985
89	Prion diseases_Homo sapiens_hsa05020	0.43804872
90	p53 signaling pathway_Homo sapiens_hsa04115	0.41335650
91	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.41308233
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39629161
93	Tuberculosis_Homo sapiens_hsa05152	0.37672243
94	Olfactory transduction_Homo sapiens_hsa04740	0.37328182
95	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.37245538
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.35391432
97	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35268754
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.33767254
99	Insulin signaling pathway_Homo sapiens_hsa04910	0.33049971
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.32958957

KRTAP22-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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