KRTAP24-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)8.54655488
2peptide cross-linking (GO:0018149)8.45721337
3adhesion of symbiont to host (GO:0044406)8.45614184
4cell wall macromolecule metabolic process (GO:0044036)8.22990430
5cell wall macromolecule catabolic process (GO:0016998)8.22990430
6hair follicle morphogenesis (GO:0031069)7.98584135
7establishment of skin barrier (GO:0061436)6.74553079
8intermediate filament cytoskeleton organization (GO:0045104)6.57577155
9intermediate filament-based process (GO:0045103)6.36330112
10epidermis development (GO:0008544)6.34724169
11keratinocyte differentiation (GO:0030216)6.32278814
12regulation of water loss via skin (GO:0033561)5.94662765
13citrulline metabolic process (GO:0000052)5.59947364
14hair cycle process (GO:0022405)5.58336727
15molting cycle process (GO:0022404)5.58336727
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.43123972
17skin morphogenesis (GO:0043589)5.16504533
18epidermal cell differentiation (GO:0009913)4.97621618
19hemidesmosome assembly (GO:0031581)4.76151260
20peptidyl-arginine modification (GO:0018195)4.74384760
21tooth mineralization (GO:0034505)4.40440214
22keratinocyte development (GO:0003334)4.08007133
23multicellular organismal water homeostasis (GO:0050891)4.01673856
24molting cycle (GO:0042303)32.1324372
25hair cycle (GO:0042633)32.1324372
26hair follicle development (GO:0001942)3.78465979
27negative regulation of keratinocyte proliferation (GO:0010839)3.57954459
28bone trabecula formation (GO:0060346)3.49917712
29positive regulation of hair cycle (GO:0042635)3.45333081
30positive regulation of hair follicle development (GO:0051798)3.45333081
31regulation of keratinocyte differentiation (GO:0045616)3.43736589
32regulation of hair follicle development (GO:0051797)3.30321615
33water homeostasis (GO:0030104)3.27911903
34fatty acid elongation (GO:0030497)3.22652809
35negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.22067454
36gap junction assembly (GO:0016264)3.16595086
37positive regulation of meiotic cell cycle (GO:0051446)3.14492592
38regulation of hair cycle (GO:0042634)3.08237178
39epithelium development (GO:0060429)3.05373847
40phosphatidylinositol acyl-chain remodeling (GO:0036149)2.96215241
41epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.96160818
42ectoderm development (GO:0007398)2.96092694
43positive regulation of epidermis development (GO:0045684)2.78761801
44atrioventricular valve morphogenesis (GO:0003181)2.77547454
45phosphatidylserine acyl-chain remodeling (GO:0036150)2.69369516
46cranial suture morphogenesis (GO:0060363)2.68810471
47negative regulation of protein localization to plasma membrane (GO:1903077)2.65751113
48cell surface receptor signaling pathway involved in heart development (GO:0061311)2.65506065
49regulation of epidermal cell differentiation (GO:0045604)2.62440592
50regulation of mesenchymal cell apoptotic process (GO:2001053)2.61429883
51regulation of epidermis development (GO:0045682)2.53434671
52negative regulation of cell fate specification (GO:0009996)2.52123115
53lymph vessel development (GO:0001945)2.51859476
54wound healing, spreading of epidermal cells (GO:0035313)2.47789406
55negative regulation of epidermis development (GO:0045683)2.42400669
56ventricular cardiac muscle cell action potential (GO:0086005)2.40335626
57phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.39990919
58skin development (GO:0043588)2.35578395
59outflow tract septum morphogenesis (GO:0003148)2.30922915
60myotube differentiation (GO:0014902)2.27814676
61planar cell polarity pathway involved in neural tube closure (GO:0090179)2.25965921
62positive regulation of epidermal cell differentiation (GO:0045606)2.25903387
63positive regulation of monocyte chemotaxis (GO:0090026)2.18297956
64regulation of keratinocyte proliferation (GO:0010837)2.14317297
65regulation of cardioblast differentiation (GO:0051890)2.13552416
66non-canonical Wnt signaling pathway (GO:0035567)2.13090130
67epithelial cell-cell adhesion (GO:0090136)2.12921652
68regulation of ruffle assembly (GO:1900027)2.11324825
69keratinocyte proliferation (GO:0043616)2.11288146
70regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.10566688
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.09345870
72phosphatidylserine metabolic process (GO:0006658)2.05837517
73regulation of heart rate by cardiac conduction (GO:0086091)2.02924508
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.01690431
75negative regulation of epidermal cell differentiation (GO:0045605)2.01074159
76keratinization (GO:0031424)11.9315236
77intermediate filament organization (GO:0045109)11.6664542
78desmosome organization (GO:0002934)10.9679321
79adhesion of symbiont to host cell (GO:0044650)10.0968679
80virion attachment to host cell (GO:0019062)10.0968679
81phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.99937146
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.98843774
83regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.97930371
84ephrin receptor signaling pathway (GO:0048013)1.96021419
85cell communication involved in cardiac conduction (GO:0086065)1.92582731
86very long-chain fatty acid metabolic process (GO:0000038)1.90818577
87craniofacial suture morphogenesis (GO:0097094)1.90600890
88coronary vasculature morphogenesis (GO:0060977)1.90083665
89establishment of planar polarity (GO:0001736)1.89185485
90establishment of tissue polarity (GO:0007164)1.89185485
91lateral sprouting from an epithelium (GO:0060601)1.86348562
92regulation of secondary heart field cardioblast proliferation (GO:0003266)1.85679654
93regulation of cardioblast proliferation (GO:0003264)1.85679654
94aging (GO:0007568)1.83275671
95odontogenesis of dentin-containing tooth (GO:0042475)1.81682160
96long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.79754576
97negative regulation of cell fate commitment (GO:0010454)1.77428739
98phosphatidylcholine acyl-chain remodeling (GO:0036151)1.75575464
99cell-substrate junction assembly (GO:0007044)1.75032512
100regulation of cell fate specification (GO:0042659)1.74283676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.73986565
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.97877074
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.61258245
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.33870946
5CTCF_20526341_ChIP-Seq_ESCs_Human2.11342184
6TP63_17297297_ChIP-ChIP_HaCaT_Human12.6054072
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.96301997
8SOX9_24532713_ChIP-Seq_HFSC_Mouse1.92216886
9BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.85087091
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.79706735
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69768325
12EGR1_19032775_ChIP-ChIP_M12_Human1.69744124
13ERG_20517297_ChIP-Seq_VCAP_Human1.69102667
14TAF2_19829295_ChIP-Seq_ESCs_Human1.66194207
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.65325029
16E2F1_20622854_ChIP-Seq_HELA_Human1.64483076
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.63994637
18CSB_26484114_Chip-Seq_FIBROBLAST_Human1.59956172
19NANOG_20526341_ChIP-Seq_ESCs_Human1.56100339
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53916054
21SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53916054
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.53029275
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.50565643
24P53_21459846_ChIP-Seq_SAOS-2_Human1.49882012
25CTCF_27219007_Chip-Seq_Bcells_Human1.49690351
26TP63_22573176_ChIP-Seq_HFKS_Human1.43623034
27RACK7_27058665_Chip-Seq_MCF-7_Human1.43241035
28MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.42718387
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.38430033
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.36270407
31AHR_22903824_ChIP-Seq_MCF-7_Human1.34364306
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34223684
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.32187780
34BCL6_27268052_Chip-Seq_Bcells_Human1.31340678
35ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30379708
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29441123
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28859320
38LXR_22292898_ChIP-Seq_THP-1_Human1.26389607
39TP63_23658742_ChIP-Seq_EP156T_Human1.25187759
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.25132810
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24711716
42ATF3_27146783_Chip-Seq_COLON_Human1.23447553
43BCOR_27268052_Chip-Seq_Bcells_Human1.23271827
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21842528
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17635271
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.17091758
47TP53_18474530_ChIP-ChIP_U2OS_Human1.14478359
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13069198
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12310898
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11362366
51AR_21572438_ChIP-Seq_LNCaP_Human1.11245565
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.10649424
53UBF1/2_26484160_Chip-Seq_HMECs_Human1.10226948
54PHF8_20622854_ChIP-Seq_HELA_Human1.07790835
55* CEBPB_22108803_ChIP-Seq_LS180_Human1.07249969
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06639449
57KLF5_25053715_ChIP-Seq_YYC3_Human1.04897130
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02985828
59P68_20966046_ChIP-Seq_HELA_Human1.01644356
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00555372
61ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00263616
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00150889
63P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99207704
64RXR_22108803_ChIP-Seq_LS180_Human0.97913805
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97393427
66ZNF263_19887448_ChIP-Seq_K562_Human0.96299600
67RAC3_21632823_ChIP-Seq_H3396_Human0.96000275
68JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95699390
69ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95192338
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94860363
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94571501
72SMC4_20622854_ChIP-Seq_HELA_Human0.94253308
73SA1_27219007_Chip-Seq_ERYTHROID_Human0.94209243
74* GATA4_25053715_ChIP-Seq_YYC3_Human0.94158958
75GATA6_21074721_ChIP-Seq_CACO-2_Human0.94084397
76RUNX1_27514584_Chip-Seq_MCF-7_Human0.93662508
77RING1B_27294783_Chip-Seq_ESCs_Mouse0.93367953
78SOX2_21211035_ChIP-Seq_LN229_Human0.92549042
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92258534
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89451763
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88805237
82SOX2_20726797_ChIP-Seq_SW620_Human0.88290569
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87388373
84FOXH1_21741376_ChIP-Seq_ESCs_Human0.84222525
85RNF2_27304074_Chip-Seq_ESCs_Mouse0.84108356
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81913800
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80956745
88SPI1_20517297_ChIP-Seq_HL60_Human0.80086072
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79919856
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.78482854
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.78053780
92ERG_21242973_ChIP-ChIP_JURKAT_Human0.77333389
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76402465
94RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76386721
95TCF4_18268006_ChIP-ChIP_LS174T_Human0.76019157
96BCAT_22108803_ChIP-Seq_LS180_Human0.74359464
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.73921385
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.73261995
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73162406
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71974983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.61548496
2MP0002098_abnormal_vibrissa_morphology6.75159092
3MP0000647_abnormal_sebaceous_gland6.18411260
4MP0002796_impaired_skin_barrier6.07607883
5MP0005275_abnormal_skin_tensile5.51911841
6MP0000383_abnormal_hair_follicle5.07332098
7MP0010234_abnormal_vibrissa_follicle4.67003863
8MP0010678_abnormal_skin_adnexa4.42152060
9MP0000377_abnormal_hair_follicle4.00087175
10MP0000427_abnormal_hair_cycle3.79303250
11MP0005501_abnormal_skin_physiology3.71922261
12MP0003705_abnormal_hypodermis_morpholog3.35479045
13MP0002254_reproductive_system_inflammat3.16990135
14MP0001216_abnormal_epidermal_layer2.69194555
15MP0004947_skin_inflammation2.38402077
16MP0010771_integument_phenotype2.37458848
17MP0004381_abnormal_hair_follicle2.27035268
18MP0001243_abnormal_dermal_layer2.25221204
19MP0000367_abnormal_coat/_hair2.24549929
20MP0002060_abnormal_skin_morphology2.20498817
21MP0003453_abnormal_keratinocyte_physiol2.05852915
22MP0002234_abnormal_pharynx_morphology1.75602388
23MP0000467_abnormal_esophagus_morphology1.50512448
24MP0009931_abnormal_skin_appearance1.49715478
25MP0003941_abnormal_skin_development1.42571674
26MP0000762_abnormal_tongue_morphology1.40175818
27MP0009053_abnormal_anal_canal1.37005359
28MP0003566_abnormal_cell_adhesion1.28868634
29MP0005409_darkened_coat_color1.22301235
30MP0001661_extended_life_span1.15751440
31MP0002095_abnormal_skin_pigmentation1.14545251
32MP0001191_abnormal_skin_condition1.04854524
33MP0004885_abnormal_endolymph0.96778727
34MP0004185_abnormal_adipocyte_glucose0.95927499
35MP0004264_abnormal_extraembryonic_tissu0.92587123
36MP0001346_abnormal_lacrimal_gland0.91391152
37MP0000566_synostosis0.86600393
38MP0008438_abnormal_cutaneous_collagen0.78089874
39MP0001340_abnormal_eyelid_morphology0.76265799
40MP0001851_eye_inflammation0.72241321
41MP0010030_abnormal_orbit_morphology0.68425674
42MP0002877_abnormal_melanocyte_morpholog0.64696077
43MP0000627_abnormal_mammary_gland0.56973006
44MP0001849_ear_inflammation0.56448085
45MP0009379_abnormal_foot_pigmentation0.54818131
46MP0003315_abnormal_perineum_morphology0.53684595
47MP0002009_preneoplasia0.51812059
48MP0001784_abnormal_fluid_regulation0.51519489
49MP0003755_abnormal_palate_morphology0.49323670
50MP0002282_abnormal_trachea_morphology0.48645214
51MP0002970_abnormal_white_adipose0.41643395
52MP0005023_abnormal_wound_healing0.41547164
53MP0002249_abnormal_larynx_morphology0.41244304
54MP0002177_abnormal_outer_ear0.40513064
55MP0002111_abnormal_tail_morphology0.40126234
56MP0003191_abnormal_cellular_cholesterol0.37347194
57MP0003385_abnormal_body_wall0.37288182
58MP0005451_abnormal_body_composition0.37128201
59MP0005248_abnormal_Harderian_gland0.36985497
60MP0004272_abnormal_basement_membrane0.34169332
61MP0000537_abnormal_urethra_morphology0.33314215
62MP0010352_gastrointestinal_tract_polyps0.33271349
63MP0002697_abnormal_eye_size0.32674368
64MP0005075_abnormal_melanosome_morpholog0.32139525
65MP0009384_cardiac_valve_regurgitation0.32062645
66MP0000432_abnormal_head_morphology0.29426621
67MP0000678_abnormal_parathyroid_gland0.27800202
68MP0002166_altered_tumor_susceptibility0.27626720
69MP0005367_renal/urinary_system_phenotyp0.25321988
70MP0000516_abnormal_urinary_system0.25321988
71MP0003950_abnormal_plasma_membrane0.24989356
72MP0002006_tumorigenesis0.24733423
73MP0003300_gastrointestinal_ulcer0.21858637
74MP0003935_abnormal_craniofacial_develop0.21398039
75MP0006054_spinal_hemorrhage0.19426176
76MP0003763_abnormal_thymus_physiology0.18961135
77MP0001188_hyperpigmentation0.18308151
78MP0005666_abnormal_adipose_tissue0.17745690
79MP0005257_abnormal_intraocular_pressure0.17682105
80MP0000751_myopathy0.16192229
81MP0005076_abnormal_cell_differentiation0.15544868
82MP0001879_abnormal_lymphatic_vessel0.15476359
83MP0000465_gastrointestinal_hemorrhage0.14690752
84MP0005508_abnormal_skeleton_morphology0.13227505
85MP0005375_adipose_tissue_phenotype0.13076552
86MP0000733_abnormal_muscle_development0.12528269
87MP0005193_abnormal_anterior_eye0.11635398
88MP0002233_abnormal_nose_morphology0.09906467
89MP0004742_abnormal_vestibular_system0.09565762
90MP0000428_abnormal_craniofacial_morphol0.09328287
91MP0001286_abnormal_eye_development0.08816906
92MP0001958_emphysema0.08721825
93MP0005503_abnormal_tendon_morphology0.08664002
94MP0001730_embryonic_growth_arrest0.08650667
95MP0003937_abnormal_limbs/digits/tail_de0.08464607
96MP0002896_abnormal_bone_mineralization0.08403052
97MP0004019_abnormal_vitamin_homeostasis0.08261194
98MP0003448_altered_tumor_morphology0.07302656
99MP0003638_abnormal_response/metabolism_0.06953114
100MP0000750_abnormal_muscle_regeneration0.06896355

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.34941494
2Nail dystrophy (HP:0008404)6.58682776
3Abnormal hair laboratory examination (HP:0003328)6.33208579
4Abnormality of nail color (HP:0100643)5.90524747
5Fragile nails (HP:0001808)5.56961448
6Follicular hyperkeratosis (HP:0007502)5.29857635
7Fine hair (HP:0002213)4.93117261
8Alopecia of scalp (HP:0002293)4.79353427
9Palmoplantar hyperkeratosis (HP:0000972)4.74678039
10Onycholysis (HP:0001806)4.72756299
11Increased IgE level (HP:0003212)4.65641435
12Palmar hyperkeratosis (HP:0010765)4.47374998
13Plantar hyperkeratosis (HP:0007556)4.31811236
14Right ventricular cardiomyopathy (HP:0011663)4.20371177
15Erythema (HP:0010783)4.01407285
16Sparse eyelashes (HP:0000653)4.00058919
17Thick nail (HP:0001805)3.83661131
18Congenital, generalized hypertrichosis (HP:0004540)3.64512126
19Abnormality of the frontal sinuses (HP:0002687)3.48684958
20Parakeratosis (HP:0001036)3.33850198
21Amelogenesis imperfecta (HP:0000705)3.27827234
22Oral leukoplakia (HP:0002745)3.20302101
23Erythroderma (HP:0001019)3.14723740
24Milia (HP:0001056)2.91444512
25Curly hair (HP:0002212)2.80253401
26Aplasia cutis congenita (HP:0001057)2.71678591
27Congenital ichthyosiform erythroderma (HP:0007431)2.56161946
28Intention tremor (HP:0002080)2.53283169
29Neck muscle weakness (HP:0000467)2.49096129
30Ridged nail (HP:0001807)2.45105618
31Advanced eruption of teeth (HP:0006288)2.30356471
32Dry hair (HP:0011359)2.29478286
33Natal tooth (HP:0000695)2.26710541
34Abnormal blistering of the skin (HP:0008066)2.24882728
35Corneal erosion (HP:0200020)2.12974533
36Torticollis (HP:0000473)2.10867232
37Conjunctival hamartoma (HP:0100780)2.08003266
38Concave nail (HP:0001598)2.07979261
39Hypohidrosis (HP:0000966)2.06534443
40Abnormality of the parietal bone (HP:0002696)2.05252205
41Pruritus (HP:0000989)2.03787232
42Ventricular tachycardia (HP:0004756)2.02553794
43Abnormality of the dental root (HP:0006486)2.02031742
44Taurodontia (HP:0000679)2.02031742
45Abnormality of permanent molar morphology (HP:0011071)2.02031742
46Palmoplantar keratoderma (HP:0000982)2.01408286
47Hypotrichosis (HP:0001006)13.7838464
48Woolly hair (HP:0002224)11.5011710
49Slow-growing hair (HP:0002217)10.2841933
50Abnormality of hair growth rate (HP:0011363)10.2841933
51Pili torti (HP:0003777)10.0559266
52Abnormality of molar (HP:0011077)1.98732701
53Abnormality of molar morphology (HP:0011070)1.98732701
54Absent eyelashes (HP:0000561)1.96636901
55Widely patent fontanelles and sutures (HP:0004492)1.90226302
56Abnormality of dental color (HP:0011073)1.87647647
57Hyporeflexia of lower limbs (HP:0002600)1.85045432
58Difficulty walking (HP:0002355)1.81813980
59Abnormality of the dental pulp (HP:0006479)1.76664357
60Craniofacial dystonia (HP:0012179)1.75489710
61Recurrent corneal erosions (HP:0000495)1.74605592
62Round ear (HP:0100830)1.73746554
63Lip pit (HP:0100267)1.73252828
64Abnormality of the pupil (HP:0000615)1.73136238
65Amniotic constriction ring (HP:0009775)1.67028885
66Abnormality of placental membranes (HP:0011409)1.67028885
67Ventricular fibrillation (HP:0001663)1.66419681
68Type 1 muscle fiber predominance (HP:0003803)1.65620063
69Blepharitis (HP:0000498)1.60460648
70Focal dystonia (HP:0004373)1.59393834
71Acanthosis nigricans (HP:0000956)1.55816277
72Craniofacial hyperostosis (HP:0004493)1.52114084
73Unilateral renal agenesis (HP:0000122)1.51228156
74Keratoconjunctivitis sicca (HP:0001097)1.47521020
75Abnormality of the aortic arch (HP:0012303)1.47019154
76Distal arthrogryposis (HP:0005684)1.43962662
77Gangrene (HP:0100758)1.42863571
78Sudden death (HP:0001699)1.42668987
79Autoamputation (HP:0001218)1.41882616
80Widely spaced teeth (HP:0000687)1.40325246
81Carious teeth (HP:0000670)1.38865835
82Distal lower limb muscle weakness (HP:0009053)1.37131869
83Ectropion (HP:0000656)1.35266665
84Fatigable weakness (HP:0003473)1.33580220
85Abnormality of the neuromuscular junction (HP:0003398)1.33580220
86Sparse scalp hair (HP:0002209)1.32337463
87Increased connective tissue (HP:0009025)1.32183599
88Keratoconjunctivitis (HP:0001096)1.29608355
89Calcaneovalgus deformity (HP:0001848)1.29360501
90Hypergammaglobulinemia (HP:0010702)1.29276149
91Hamartoma of the eye (HP:0010568)1.28864252
92Abnormality of the fingernails (HP:0001231)1.25514685
93Atrophic scars (HP:0001075)1.24593701
94Anonychia (HP:0001798)1.23732210
95Heterogeneous (HP:0001425)1.23489851
96Achilles tendon contracture (HP:0001771)1.23154402
97Ulnar deviation of the wrist (HP:0003049)1.22702283
98Nemaline bodies (HP:0003798)1.20185315
99Selective tooth agenesis (HP:0001592)1.17974788
100Wide cranial sutures (HP:0010537)1.16044387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.00798458
2EPHA23.91086810
3MAPKAPK33.72214445
4EPHB23.46826140
5LATS13.23628862
6ERN13.20338914
7MAP3K63.00710762
8PIK3CG2.97281462
9MAP3K32.89473516
10TAOK12.87046073
11MAP3K22.75818458
12FGFR22.43041987
13TTN2.38991814
14TRIB32.27032881
15BCR2.05216671
16RPS6KB21.98577390
17MAP3K111.87710769
18FGFR11.80642923
19OBSCN1.59476774
20LATS21.53278324
21FGFR31.52643052
22MAP2K61.51472054
23CDK61.43013379
24PBK1.40766139
25EEF2K1.38149846
26EPHB11.37885106
27MST1R1.34858411
28RIPK11.26404081
29NME11.20122378
30MAP3K11.16804784
31MAP3K71.07222332
32MAP2K31.06223229
33MAPKAPK21.05605135
34PTK61.02866048
35PDGFRA1.02445152
36KSR21.01811027
37DYRK1B0.95082419
38BMX0.93537035
39LRRK20.93413539
40RPS6KA40.84487420
41TRPM70.84115120
42SIK10.81699104
43FGFR40.78608530
44STK38L0.78428837
45ERBB40.76908418
46MAP2K40.75631952
47MST40.74682014
48MET0.73292159
49ERBB30.71675992
50PKN20.71456844
51TESK10.70761116
52PTK20.70351951
53NEK10.67507196
54MAP2K10.66429710
55MAP3K90.66010536
56PRKD10.65961668
57STK380.64660491
58CDK190.63741765
59FRK0.60600290
60PIM20.60444980
61BLK0.60427442
62ERBB20.57612620
63PHKG10.56377228
64PHKG20.56377228
65STK30.54692028
66MAP3K50.53023716
67STK240.52174259
68PAK40.50437603
69PAK30.49784781
70DDR20.49739207
71NTRK20.48954923
72PRKCI0.46630573
73GSK3A0.44606196
74TGFBR10.43718934
75CSNK1E0.43545119
76PRKCH0.41697145
77TYRO30.41167927
78MAP3K100.38861333
79RPS6KA10.38665598
80MAPK120.36002891
81RET0.35564554
82PAK20.34648303
83MARK30.33565082
84CSNK1A1L0.33221185
85CSNK1G10.32687789
86DMPK0.31612201
87LIMK10.29635357
88SCYL20.26229235
89TGFBR20.25935407
90CSNK1D0.25735914
91PDPK10.25331758
92STK110.24891447
93FYN0.24700619
94MAP2K20.24443516
95ILK0.24212829
96PRKACA0.23737320
97CSNK1A10.23222171
98JAK10.22720725
99PAK60.22667834
100JAK20.21816237

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.03482502
2Linoleic acid metabolism_Homo sapiens_hsa005914.02305479
3Fatty acid elongation_Homo sapiens_hsa000623.18289689
4Basal cell carcinoma_Homo sapiens_hsa052172.69951296
5Fat digestion and absorption_Homo sapiens_hsa049752.52106726
6Ether lipid metabolism_Homo sapiens_hsa005652.23004010
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96926871
8Melanogenesis_Homo sapiens_hsa049161.82350790
9Phenylalanine metabolism_Homo sapiens_hsa003601.81420380
10Hedgehog signaling pathway_Homo sapiens_hsa043401.74425502
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69947670
12Axon guidance_Homo sapiens_hsa043601.64856792
13VEGF signaling pathway_Homo sapiens_hsa043701.64058419
14Hippo signaling pathway_Homo sapiens_hsa043901.62289263
15Arachidonic acid metabolism_Homo sapiens_hsa005901.54114255
16Bladder cancer_Homo sapiens_hsa052191.52335572
17Glioma_Homo sapiens_hsa052141.51817653
18Thyroid cancer_Homo sapiens_hsa052161.49572523
19Proteoglycans in cancer_Homo sapiens_hsa052051.47017796
20Tight junction_Homo sapiens_hsa045301.45115413
21Dorso-ventral axis formation_Homo sapiens_hsa043201.36764455
22Mineral absorption_Homo sapiens_hsa049781.36065831
23Histidine metabolism_Homo sapiens_hsa003401.34739750
24Adherens junction_Homo sapiens_hsa045201.33425234
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.23744386
26GnRH signaling pathway_Homo sapiens_hsa049121.23112730
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20957512
28Long-term potentiation_Homo sapiens_hsa047201.19054732
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17183285
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16827933
31Acute myeloid leukemia_Homo sapiens_hsa052211.16573849
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11437045
33Steroid biosynthesis_Homo sapiens_hsa001001.10554075
34Endometrial cancer_Homo sapiens_hsa052131.08866786
35Tyrosine metabolism_Homo sapiens_hsa003501.08077989
36Wnt signaling pathway_Homo sapiens_hsa043101.06760210
37ECM-receptor interaction_Homo sapiens_hsa045121.05271848
38PPAR signaling pathway_Homo sapiens_hsa033201.03158043
39Leukocyte transendothelial migration_Homo sapiens_hsa046700.98500729
40Non-small cell lung cancer_Homo sapiens_hsa052230.98457131
41Caffeine metabolism_Homo sapiens_hsa002320.96655019
42TGF-beta signaling pathway_Homo sapiens_hsa043500.93256215
43Pancreatic secretion_Homo sapiens_hsa049720.92144971
44Long-term depression_Homo sapiens_hsa047300.89806279
45Nitrogen metabolism_Homo sapiens_hsa009100.88239873
46MicroRNAs in cancer_Homo sapiens_hsa052060.85643104
47Pertussis_Homo sapiens_hsa051330.82999292
48Amoebiasis_Homo sapiens_hsa051460.81838720
49Estrogen signaling pathway_Homo sapiens_hsa049150.80818873
50Ras signaling pathway_Homo sapiens_hsa040140.78530115
51Renin secretion_Homo sapiens_hsa049240.75084975
52Phototransduction_Homo sapiens_hsa047440.71414446
53Gastric acid secretion_Homo sapiens_hsa049710.71201073
54Insulin resistance_Homo sapiens_hsa049310.70870974
55beta-Alanine metabolism_Homo sapiens_hsa004100.70642129
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.69872210
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69474169
58Focal adhesion_Homo sapiens_hsa045100.66789231
59Fatty acid metabolism_Homo sapiens_hsa012120.66077517
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65714205
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.64733977
62Hepatitis C_Homo sapiens_hsa051600.64367957
63Staphylococcus aureus infection_Homo sapiens_hsa051500.63153452
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61993880
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61908508
66Rap1 signaling pathway_Homo sapiens_hsa040150.60075553
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59129075
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58300289
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58198685
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.57589186
71Platelet activation_Homo sapiens_hsa046110.57365829
72Oxytocin signaling pathway_Homo sapiens_hsa049210.57297465
73Protein digestion and absorption_Homo sapiens_hsa049740.57252601
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57183529
75Renal cell carcinoma_Homo sapiens_hsa052110.56989071
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.56902311
77Chemical carcinogenesis_Homo sapiens_hsa052040.56755062
78p53 signaling pathway_Homo sapiens_hsa041150.54329970
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52232586
80Gap junction_Homo sapiens_hsa045400.51750357
81Melanoma_Homo sapiens_hsa052180.51684450
82ErbB signaling pathway_Homo sapiens_hsa040120.49782375
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.48828319
84Salmonella infection_Homo sapiens_hsa051320.47684536
85Chronic myeloid leukemia_Homo sapiens_hsa052200.46393676
86Fatty acid degradation_Homo sapiens_hsa000710.45140638
87Insulin signaling pathway_Homo sapiens_hsa049100.44300597
88Prostate cancer_Homo sapiens_hsa052150.43139981
89Butanoate metabolism_Homo sapiens_hsa006500.43033221
90Salivary secretion_Homo sapiens_hsa049700.42338576
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41382841
92Notch signaling pathway_Homo sapiens_hsa043300.41249565
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41224938
94Pathways in cancer_Homo sapiens_hsa052000.39989798
95Sphingolipid metabolism_Homo sapiens_hsa006000.38824785
96Fatty acid biosynthesis_Homo sapiens_hsa000610.38608527
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35816534
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34835586
99Tuberculosis_Homo sapiens_hsa051520.34744533
100Dilated cardiomyopathy_Homo sapiens_hsa054140.33573095

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