KRTAP3-1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)8.95501930
2peptide cross-linking (GO:0018149)8.52916830
3adhesion of symbiont to host (GO:0044406)8.49818027
4hair follicle morphogenesis (GO:0031069)8.29565737
5fat-soluble vitamin catabolic process (GO:0042363)6.84674956
6vitamin catabolic process (GO:0009111)6.84674956
7intermediate filament cytoskeleton organization (GO:0045104)6.73102052
8intermediate filament-based process (GO:0045103)6.51739700
9epidermis development (GO:0008544)6.09361375
10citrulline metabolic process (GO:0000052)5.94012649
11cell wall macromolecule catabolic process (GO:0016998)5.93113104
12cell wall macromolecule metabolic process (GO:0044036)5.93113104
13establishment of skin barrier (GO:0061436)5.89091000
14keratinocyte differentiation (GO:0030216)5.81778762
15regulation of female receptivity (GO:0045924)5.36578713
16hair cycle process (GO:0022405)5.30555126
17molting cycle process (GO:0022404)5.30555126
18bundle of His cell to Purkinje myocyte communication (GO:0086069)5.22357562
19regulation of water loss via skin (GO:0033561)5.21639858
20peptidyl-arginine modification (GO:0018195)4.93690454
21hemidesmosome assembly (GO:0031581)4.86067855
22skin morphogenesis (GO:0043589)4.84869562
23regulation of MHC class II biosynthetic process (GO:0045346)4.65850215
24female mating behavior (GO:0060180)4.64045293
25lipoxygenase pathway (GO:0019372)4.57795443
26epidermal cell differentiation (GO:0009913)4.53102984
27detection of light stimulus involved in sensory perception (GO:0050962)4.36598678
28detection of light stimulus involved in visual perception (GO:0050908)4.36598678
29skeletal muscle tissue regeneration (GO:0043403)4.33015474
30mature B cell differentiation involved in immune response (GO:0002313)4.23496306
31positive regulation of chemokine secretion (GO:0090197)4.19875367
32regulation of chemokine secretion (GO:0090196)4.00699377
33molting cycle (GO:0042303)35.1231528
34hair cycle (GO:0042633)35.1231528
35phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.96194681
36positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.95992490
37polarized epithelial cell differentiation (GO:0030859)3.94839033
38protoporphyrinogen IX biosynthetic process (GO:0006782)3.86758945
39keratinocyte development (GO:0003334)3.78635255
40tooth mineralization (GO:0034505)3.74785211
41protein targeting to vacuole (GO:0006623)3.68232918
42protein targeting to lysosome (GO:0006622)3.68232918
43establishment of protein localization to vacuole (GO:0072666)3.68232918
44linoleic acid metabolic process (GO:0043651)3.61552713
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.60190040
46coenzyme catabolic process (GO:0009109)3.56031210
47multicellular organismal water homeostasis (GO:0050891)3.50619256
48long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.49077910
49negative regulation of keratinocyte proliferation (GO:0010839)3.39940226
50negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.35090285
51tachykinin receptor signaling pathway (GO:0007217)3.32235827
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.31737816
53positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.31060038
54retinol metabolic process (GO:0042572)3.27731365
55regulation of keratinocyte differentiation (GO:0045616)3.24123724
56regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.24089685
57long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.22569973
58cellular glucuronidation (GO:0052695)3.21540727
59defense response to fungus (GO:0050832)3.19134471
60negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.17845556
61killing of cells of other organism (GO:0031640)3.15591047
62disruption of cells of other organism (GO:0044364)3.15591047
63adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14509991
64positive regulation of action potential (GO:0045760)3.14196844
65glucuronate metabolic process (GO:0019585)3.12267304
66uronic acid metabolic process (GO:0006063)3.12267304
67fatty-acyl-CoA biosynthetic process (GO:0046949)3.10521716
68positive regulation of hair cycle (GO:0042635)3.10229622
69positive regulation of hair follicle development (GO:0051798)3.10229622
70hair follicle development (GO:0001942)3.09722057
71phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.03714614
72synaptic transmission, dopaminergic (GO:0001963)2.98222882
73pantothenate metabolic process (GO:0015939)2.96562617
74protoporphyrinogen IX metabolic process (GO:0046501)2.94643665
75purine deoxyribonucleotide catabolic process (GO:0009155)2.93734690
76regulation of inositol phosphate biosynthetic process (GO:0010919)2.91111287
77regulation of hair follicle development (GO:0051797)2.90925351
78water homeostasis (GO:0030104)2.87342978
79epithelium development (GO:0060429)2.87146127
80base-excision repair, AP site formation (GO:0006285)2.86463699
81mature B cell differentiation (GO:0002335)2.84317411
82endothelial tube morphogenesis (GO:0061154)2.83912053
83morphogenesis of an endothelium (GO:0003159)2.83912053
84long term synaptic depression (GO:0060292)2.83687454
85lymphangiogenesis (GO:0001946)2.83595582
86N-acetylneuraminate metabolic process (GO:0006054)2.79328952
87regulation of sensory perception (GO:0051931)2.78959692
88regulation of sensory perception of pain (GO:0051930)2.78959692
89ectoderm development (GO:0007398)2.77686827
90transmission of nerve impulse (GO:0019226)2.75493193
91positive regulation of histone deacetylation (GO:0031065)2.74911750
92embryonic heart tube development (GO:0035050)2.74580517
93positive regulation of epidermis development (GO:0045684)2.71129132
94collecting duct development (GO:0072044)2.70173092
95negative regulation of oxidoreductase activity (GO:0051354)2.69668314
96nonmotile primary cilium assembly (GO:0035058)2.68846300
97neuronal action potential (GO:0019228)2.68730957
98protein localization to lysosome (GO:0061462)2.67099012
99protein localization to vacuole (GO:0072665)2.67099012
100gap junction assembly (GO:0016264)2.66186079
101glycosphingolipid biosynthetic process (GO:0006688)2.64533457
102atrioventricular valve morphogenesis (GO:0003181)2.63699477
103negative regulation of protein localization to plasma membrane (GO:1903077)2.62421980
104bone trabecula formation (GO:0060346)2.61371489
105DNA deamination (GO:0045006)2.60088032
106fatty acid elongation (GO:0030497)2.56896692
107regulation of hair cycle (GO:0042634)2.56496081
108fat-soluble vitamin biosynthetic process (GO:0042362)2.56047621
109regulation of epidermal cell differentiation (GO:0045604)2.53803770
110positive regulation of meiotic cell cycle (GO:0051446)2.53630739
111positive regulation of keratinocyte differentiation (GO:0045618)2.52126592
112fatty-acyl-CoA metabolic process (GO:0035337)2.49563935
113acyl-CoA biosynthetic process (GO:0071616)2.48779751
114thioester biosynthetic process (GO:0035384)2.48779751
115positive regulation of interleukin-8 secretion (GO:2000484)2.48738636
116phosphatidylserine metabolic process (GO:0006658)2.48097475
117regulation of epidermis development (GO:0045682)2.45403641
118ventricular cardiac muscle cell action potential (GO:0086005)2.44394937
119negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42291309
120phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.41499433
121regulation of sequestering of triglyceride (GO:0010889)2.39570801
122primary alcohol metabolic process (GO:0034308)2.39023128
123keratinocyte proliferation (GO:0043616)2.37559626
124N-acetylglucosamine metabolic process (GO:0006044)2.36526299
125regulation of action potential (GO:0098900)2.36068505
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35605917
127centriole replication (GO:0007099)2.32373657
128negative regulation of cell fate specification (GO:0009996)2.30989638
129cellular extravasation (GO:0045123)2.30889906
130positive regulation of epidermal cell differentiation (GO:0045606)2.24985855
131epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.23104926
132lymph vessel development (GO:0001945)2.19689092
133regulation of mesenchymal cell apoptotic process (GO:2001053)2.16441187
134positive regulation of monocyte chemotaxis (GO:0090026)2.16390191
135phosphatidylcholine acyl-chain remodeling (GO:0036151)2.12852868
136skin development (GO:0043588)2.12416916
137cell surface receptor signaling pathway involved in heart development (GO:0061311)2.08885025
138aging (GO:0007568)2.07926141
139regulation of cardioblast differentiation (GO:0051890)2.06411597
140wound healing, spreading of epidermal cells (GO:0035313)2.04736687
141regulation of heart rate by cardiac conduction (GO:0086091)2.03702149
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.03394395
143epithelial cell-cell adhesion (GO:0090136)2.01209449
144intermediate filament organization (GO:0045109)12.2569869
145keratinization (GO:0031424)11.8209401
146adhesion of symbiont to host cell (GO:0044650)10.0502234
147virion attachment to host cell (GO:0019062)10.0502234
148desmosome organization (GO:0002934)10.0278003
149myotube differentiation (GO:0014902)1.95320893
150cranial suture morphogenesis (GO:0060363)1.93233483
151outflow tract septum morphogenesis (GO:0003148)1.93171889
152regulation of keratinocyte proliferation (GO:0010837)1.92681814
153cell communication involved in cardiac conduction (GO:0086065)1.92414494
154regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.91155103
155regulation of ruffle assembly (GO:1900027)1.90663032
156negative regulation of epidermis development (GO:0045683)1.90348980
157alditol phosphate metabolic process (GO:0052646)1.84774949
158planar cell polarity pathway involved in neural tube closure (GO:0090179)1.83058906
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.80343308
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.80343308
161cell-substrate junction assembly (GO:0007044)1.78546400
162ephrin receptor signaling pathway (GO:0048013)1.78065111
163coronary vasculature morphogenesis (GO:0060977)1.71982401
164negative regulation of cell fate commitment (GO:0010454)1.70894689
165regulation of cardioblast proliferation (GO:0003264)1.70257106
166regulation of secondary heart field cardioblast proliferation (GO:0003266)1.70257106
167non-canonical Wnt signaling pathway (GO:0035567)1.68948771
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.68218941
169primary alcohol catabolic process (GO:0034310)1.66680220
170cardiac conduction (GO:0061337)1.62694650
171very long-chain fatty acid metabolic process (GO:0000038)1.61961853
172phosphatidylglycerol metabolic process (GO:0046471)1.58776823
173cellular modified amino acid biosynthetic process (GO:0042398)1.56068275
174outer ear morphogenesis (GO:0042473)1.55272996
175cardiac muscle cell action potential involved in contraction (GO:0086002)1.54430630
176phosphatidic acid biosynthetic process (GO:0006654)1.54318945
177phosphatidic acid metabolic process (GO:0046473)1.54318945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.24441670
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.76883989
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.55216105
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.62572833
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61302218
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.56196961
7IGF1R_20145208_ChIP-Seq_DFB_Human2.42213244
8CTCF_20526341_ChIP-Seq_ESCs_Human2.40389267
9GBX2_23144817_ChIP-Seq_PC3_Human2.23565682
10BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.20006507
11NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.17096174
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.07577601
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.5535720
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92741829
15E2F1_20622854_ChIP-Seq_HELA_Human1.89049123
16P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.75104293
17EGR1_19032775_ChIP-ChIP_M12_Human1.73505622
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.73455142
19CSB_26484114_Chip-Seq_FIBROBLAST_Human1.73084888
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71347427
21* TAF2_19829295_ChIP-Seq_ESCs_Human1.69620761
22AUTS2_25519132_ChIP-Seq_293T-REX_Human1.68848499
23SOX9_24532713_ChIP-Seq_HFSC_Mouse1.65360200
24CTCF_27219007_Chip-Seq_Bcells_Human1.64631007
25ERG_20517297_ChIP-Seq_VCAP_Human1.61908565
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60453865
27* NANOG_20526341_ChIP-Seq_ESCs_Human1.58297923
28P53_21459846_ChIP-Seq_SAOS-2_Human1.58181977
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58163646
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57096716
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54690376
32LXR_22292898_ChIP-Seq_THP-1_Human1.53903442
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.53336317
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52537733
35NCOR_22424771_ChIP-Seq_293T_Human1.52484896
36RACK7_27058665_Chip-Seq_MCF-7_Human1.52283440
37BCL6_27268052_Chip-Seq_Bcells_Human1.51989772
38TP63_22573176_ChIP-Seq_HFKS_Human1.50739349
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.50607099
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50099927
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50099927
42MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.49970121
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47819165
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.47819165
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.47491418
46BCOR_27268052_Chip-Seq_Bcells_Human1.44546567
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43361205
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42079801
49ATF3_27146783_Chip-Seq_COLON_Human1.39565735
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38823737
51CBP_20019798_ChIP-Seq_JUKART_Human1.37754281
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37754281
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37168395
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.36164329
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.35211770
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.31934776
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30579709
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30346751
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.29675731
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28638911
61PHF8_20622854_ChIP-Seq_HELA_Human1.28272863
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27765637
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23963019
64BCAT_22108803_ChIP-Seq_LS180_Human1.23736537
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23412070
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22833224
67P68_20966046_ChIP-Seq_HELA_Human1.21277770
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.21035056
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19040464
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18928448
71AHR_22903824_ChIP-Seq_MCF-7_Human1.18855440
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.18836065
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18232448
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18057738
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17985081
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17639839
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17608450
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.17488016
79CEBPB_22108803_ChIP-Seq_LS180_Human1.16530645
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15331725
81SMC4_20622854_ChIP-Seq_HELA_Human1.14566349
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14411416
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14034124
84RAC3_21632823_ChIP-Seq_H3396_Human1.13699114
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13006723
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.12469564
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.12347579
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.11144338
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.09897516
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09720945
91ELK4_26923725_Chip-Seq_MESODERM_Mouse1.09014175
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08951590
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08454023
94SOX2_19829295_ChIP-Seq_ESCs_Human1.07120363
95NANOG_19829295_ChIP-Seq_ESCs_Human1.07120363
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07059625
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07036065
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07036065
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06812768
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06377232
101TP63_23658742_ChIP-Seq_EP156T_Human1.05532575
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05491365
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05309132
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.03482414
105SPI1_20517297_ChIP-Seq_HL60_Human1.03245993
106SOX2_21211035_ChIP-Seq_LN229_Human1.02313635
107GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02029854
108RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01114712
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00314757
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99805606
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98787861
112KLF5_25053715_ChIP-Seq_YYC3_Human0.98778322
113AR_20517297_ChIP-Seq_VCAP_Human0.98717723
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.97541010
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97496564
116TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97432399
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97298337
118FOXH1_21741376_ChIP-Seq_EPCs_Human0.97220022
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.97072151
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.96624115
121FOXH1_21741376_ChIP-Seq_ESCs_Human0.95782733
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95780184
123* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94846112
124ER_23166858_ChIP-Seq_MCF-7_Human0.94412103
125SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93116340
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92901326
127* GATA4_25053715_ChIP-Seq_YYC3_Human0.92159652
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92049680
129GATA6_21074721_ChIP-Seq_CACO-2_Human0.91814742
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91393456
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90961013
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90814040
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90539246
134SMAD4_21799915_ChIP-Seq_A2780_Human0.89851438
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89822905
136MYC_19829295_ChIP-Seq_ESCs_Human0.89740618
137* UBF1/2_26484160_Chip-Seq_HMECs_Human0.89157430
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.88705567
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88625900
140OCT4_19829295_ChIP-Seq_ESCs_Human0.87877115
141RXR_22108803_ChIP-Seq_LS180_Human0.87177326
142RING1B_27294783_Chip-Seq_ESCs_Mouse0.86850730
143TP53_18474530_ChIP-ChIP_U2OS_Human0.86563552
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86397157
145SOX2_20726797_ChIP-Seq_SW620_Human0.85706114
146ZNF263_19887448_ChIP-Seq_K562_Human0.85317455
147GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84055331
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82296146
149EZH2_27294783_Chip-Seq_ESCs_Mouse0.79015760
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78661947
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.78400219
152ELK3_25401928_ChIP-Seq_HUVEC_Human0.77732391
153KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75738933
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.74319937
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73878054
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73434551
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72163531
158GATA6_25053715_ChIP-Seq_YYC3_Human0.72114651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.68626946
2MP0002098_abnormal_vibrissa_morphology7.17964729
3MP0000647_abnormal_sebaceous_gland6.43917269
4MP0002796_impaired_skin_barrier5.96084931
5MP0005275_abnormal_skin_tensile5.16066192
6MP0010234_abnormal_vibrissa_follicle5.12656778
7MP0000383_abnormal_hair_follicle4.48147576
8MP0005083_abnormal_biliary_tract4.27916205
9MP0000377_abnormal_hair_follicle4.09034961
10MP0002653_abnormal_ependyma_morphology4.03620703
11MP0010678_abnormal_skin_adnexa3.97627528
12MP0003705_abnormal_hypodermis_morpholog3.81003508
13MP0005501_abnormal_skin_physiology3.74417944
14MP0000427_abnormal_hair_cycle3.45893553
15MP0002736_abnormal_nociception_after3.15215386
16MP0002254_reproductive_system_inflammat2.90738708
17MP0001216_abnormal_epidermal_layer2.67169069
18MP0005377_hearing/vestibular/ear_phenot2.61814608
19MP0003878_abnormal_ear_physiology2.61814608
20MP0004381_abnormal_hair_follicle2.58441615
21MP0000367_abnormal_coat/_hair2.37608266
22MP0004947_skin_inflammation2.34403161
23MP0001968_abnormal_touch/_nociception2.31844077
24MP0005360_urolithiasis2.30264078
25MP0010771_integument_phenotype2.29585574
26MP0003453_abnormal_keratinocyte_physiol2.18681172
27MP0002060_abnormal_skin_morphology2.12342473
28MP0001243_abnormal_dermal_layer2.11383447
29MP0002234_abnormal_pharynx_morphology2.10325759
30MP0000467_abnormal_esophagus_morphology1.81336334
31MP0009379_abnormal_foot_pigmentation1.78757942
32MP0003252_abnormal_bile_duct1.68394094
33MP0002909_abnormal_adrenal_gland1.67803079
34MP0003172_abnormal_lysosome_physiology1.57218325
35MP0009053_abnormal_anal_canal1.52183348
36MP0009931_abnormal_skin_appearance1.50104705
37MP0000762_abnormal_tongue_morphology1.49511358
38MP0003566_abnormal_cell_adhesion1.46931706
39MP0005409_darkened_coat_color1.34514647
40MP0005670_abnormal_white_adipose1.25268752
41MP0006276_abnormal_autonomic_nervous1.21458534
42MP0010386_abnormal_urinary_bladder1.18386227
43MP0005085_abnormal_gallbladder_physiolo1.18380252
44MP0005365_abnormal_bile_salt1.16584506
45MP0003941_abnormal_skin_development1.14590839
46MP0001984_abnormal_olfaction1.12526874
47MP0002734_abnormal_mechanical_nocicepti1.02701462
48MP0004043_abnormal_pH_regulation1.01696706
49MP0001191_abnormal_skin_condition0.99455026
50MP0001529_abnormal_vocalization0.98254810
51MP0004885_abnormal_endolymph0.93577813
52MP0005646_abnormal_pituitary_gland0.92037827
53MP0004185_abnormal_adipocyte_glucose0.91153215
54MP0009697_abnormal_copulation0.88389369
55MP0004264_abnormal_extraembryonic_tissu0.85146602
56MP0001851_eye_inflammation0.82414746
57MP0002095_abnormal_skin_pigmentation0.80632587
58MP0003195_calcinosis0.79566311
59MP0001485_abnormal_pinna_reflex0.78596241
60MP0010329_abnormal_lipoprotein_level0.76405722
61MP0001188_hyperpigmentation0.70664493
62MP0001849_ear_inflammation0.68918173
63MP0003315_abnormal_perineum_morphology0.68041114
64MP0008438_abnormal_cutaneous_collagen0.64224844
65MP0002277_abnormal_respiratory_mucosa0.63830646
66MP0001340_abnormal_eyelid_morphology0.62182468
67MP0005451_abnormal_body_composition0.61608105
68MP0010030_abnormal_orbit_morphology0.61226019
69MP0003191_abnormal_cellular_cholesterol0.61014786
70MP0002877_abnormal_melanocyte_morpholog0.60124510
71MP0005551_abnormal_eye_electrophysiolog0.60035000
72MP0005647_abnormal_sex_gland0.59553621
73MP0001346_abnormal_lacrimal_gland0.59081564
74MP0001661_extended_life_span0.58417360
75MP0005174_abnormal_tail_pigmentation0.57689004
76MP0003646_muscle_fatigue0.56498520
77MP0000538_abnormal_urinary_bladder0.55499635
78MP0000627_abnormal_mammary_gland0.55093086
79MP0008872_abnormal_physiological_respon0.54052176
80MP0001502_abnormal_circadian_rhythm0.53523936
81MP0008961_abnormal_basal_metabolism0.53197406
82MP0002282_abnormal_trachea_morphology0.51176680
83MP0005023_abnormal_wound_healing0.49930995
84MP0000566_synostosis0.49629789
85MP0002928_abnormal_bile_duct0.48897137
86MP0003755_abnormal_palate_morphology0.48594223
87MP0002970_abnormal_white_adipose0.47643014
88MP0001784_abnormal_fluid_regulation0.45173210
89MP0008789_abnormal_olfactory_epithelium0.44980114
90MP0006035_abnormal_mitochondrial_morpho0.43433372
91MP0000026_abnormal_inner_ear0.43223184
92MP0000678_abnormal_parathyroid_gland0.40944938
93MP0000015_abnormal_ear_pigmentation0.40871943
94MP0002933_joint_inflammation0.40834809
95MP0001970_abnormal_pain_threshold0.40193017
96MP0002735_abnormal_chemical_nociception0.39640567
97MP0002249_abnormal_larynx_morphology0.39587217
98MP0002111_abnormal_tail_morphology0.37733463
99MP0005075_abnormal_melanosome_morpholog0.37687869
100MP0009840_abnormal_foam_cell0.36829249
101MP0005332_abnormal_amino_acid0.36744654
102MP0009780_abnormal_chondrocyte_physiolo0.36434225
103MP0001873_stomach_inflammation0.35845356
104MP0005671_abnormal_response_to0.34813407
105MP0010352_gastrointestinal_tract_polyps0.34493635
106MP0000465_gastrointestinal_hemorrhage0.33065124
107MP0002118_abnormal_lipid_homeostasis0.32661625
108MP0003136_yellow_coat_color0.32533582
109MP0004272_abnormal_basement_membrane0.31535930
110MP0008875_abnormal_xenobiotic_pharmacok0.31384351
111MP0001963_abnormal_hearing_physiology0.29629340
112MP0003385_abnormal_body_wall0.29595385
113MP0002272_abnormal_nervous_system0.28585078
114MP0003329_amyloid_beta_deposits0.28134835
115MP0003879_abnormal_hair_cell0.27983856
116MP0000537_abnormal_urethra_morphology0.27735505
117MP0002177_abnormal_outer_ear0.26311117
118MP0008058_abnormal_DNA_repair0.26282306
119MP0000003_abnormal_adipose_tissue0.26201215
120MP0003119_abnormal_digestive_system0.26192170
121MP0003950_abnormal_plasma_membrane0.26125922
122MP0004019_abnormal_vitamin_homeostasis0.24474170
123MP0005666_abnormal_adipose_tissue0.24379313
124MP0003763_abnormal_thymus_physiology0.24256674
125MP0005248_abnormal_Harderian_gland0.22680116
126MP0002697_abnormal_eye_size0.21959513
127MP0004858_abnormal_nervous_system0.21742132
128MP0003300_gastrointestinal_ulcer0.21389932
129MP0001879_abnormal_lymphatic_vessel0.20294395
130MP0005375_adipose_tissue_phenotype0.19531104
131MP0004742_abnormal_vestibular_system0.18044934
132MP0006054_spinal_hemorrhage0.17208408
133MP0000432_abnormal_head_morphology0.14594732
134MP0000604_amyloidosis0.14407548
135MP0003011_delayed_dark_adaptation0.14079985
136MP0003448_altered_tumor_morphology0.13989476
137MP0003638_abnormal_response/metabolism_0.13679823
138MP0005076_abnormal_cell_differentiation0.13275750
139MP0003075_altered_response_to0.13059543
140MP0003935_abnormal_craniofacial_develop0.12705586
141MP0005165_increased_susceptibility_to0.10087150
142MP0001958_emphysema0.09968598
143MP0010368_abnormal_lymphatic_system0.09560647
144MP0005367_renal/urinary_system_phenotyp0.09434691
145MP0000516_abnormal_urinary_system0.09434691
146MP0005193_abnormal_anterior_eye0.09146042
147MP0002233_abnormal_nose_morphology0.09129450
148MP0000462_abnormal_digestive_system0.08723799
149MP0000013_abnormal_adipose_tissue0.08255095
150MP0003045_fibrosis0.07968244
151MP0002006_tumorigenesis0.07652782
152MP0008569_lethality_at_weaning0.07529992
153MP0000733_abnormal_muscle_development0.07525759
154MP0002166_altered_tumor_susceptibility0.07033752
155MP0006138_congestive_heart_failure0.06408267
156MP0000751_myopathy0.04612057

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.02729081
2Nail dystrophy (HP:0008404)7.41306841
3Absent eyebrow (HP:0002223)7.19227650
4Abnormality of nail color (HP:0100643)6.42924914
5Abnormal hair laboratory examination (HP:0003328)5.70078525
6Fragile nails (HP:0001808)5.48188159
7Absent hair (HP:0002298)5.41295452
8Fine hair (HP:0002213)5.29915749
9Palmoplantar hyperkeratosis (HP:0000972)4.97644943
10Increased IgE level (HP:0003212)4.93538377
11Onycholysis (HP:0001806)4.90047214
12Alopecia of scalp (HP:0002293)4.89096862
13Thick nail (HP:0001805)4.71317384
14Palmar hyperkeratosis (HP:0010765)4.68292785
15Plantar hyperkeratosis (HP:0007556)4.50161328
16Follicular hyperkeratosis (HP:0007502)4.29362335
17Right ventricular cardiomyopathy (HP:0011663)4.28498610
18Erythema (HP:0010783)3.64131705
19Oral leukoplakia (HP:0002745)3.54066229
20Sparse eyelashes (HP:0000653)3.53183667
21Milia (HP:0001056)3.21758829
22Absent/shortened dynein arms (HP:0200106)3.13233325
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.13233325
24Abnormality of secondary sexual hair (HP:0009888)3.09509528
25Abnormality of the axillary hair (HP:0100134)3.09509528
26Erythroderma (HP:0001019)3.02834648
27Amelogenesis imperfecta (HP:0000705)3.01265857
28Failure to thrive in infancy (HP:0001531)2.95225050
29Abnormality of the frontal sinuses (HP:0002687)2.94627008
30Abnormality of cochlea (HP:0000375)2.93768234
31Parakeratosis (HP:0001036)2.78529149
32Ridged nail (HP:0001807)2.70879205
33Curly hair (HP:0002212)2.69113443
34Intention tremor (HP:0002080)2.63440981
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.60433153
36Congenital, generalized hypertrichosis (HP:0004540)2.58465790
37Dysautonomia (HP:0002459)2.50696160
38Decreased central vision (HP:0007663)2.50317570
39Abnormal blistering of the skin (HP:0008066)2.47756985
40Congenital ichthyosiform erythroderma (HP:0007431)2.47168811
41Natal tooth (HP:0000695)2.43138517
42Neck muscle weakness (HP:0000467)2.42241701
43Torticollis (HP:0000473)2.35466092
44Advanced eruption of teeth (HP:0006288)2.34649293
45Poor head control (HP:0002421)2.34555246
46Dry hair (HP:0011359)2.30969392
47Aplasia cutis congenita (HP:0001057)2.30336898
48Morphological abnormality of the inner ear (HP:0011390)2.29847866
49Bony spicule pigmentary retinopathy (HP:0007737)2.23060017
50Abolished electroretinogram (ERG) (HP:0000550)2.13033319
51Hypohidrosis (HP:0000966)2.11670936
52Corneal erosion (HP:0200020)2.09853518
53Lymphangioma (HP:0100764)2.08467115
54Palmoplantar keratoderma (HP:0000982)2.05328220
55Ventricular tachycardia (HP:0004756)2.03708812
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03585918
57Attenuation of retinal blood vessels (HP:0007843)2.00379800
58Hypotrichosis (HP:0001006)14.8715681
59Slow-growing hair (HP:0002217)11.2535240
60Abnormality of hair growth rate (HP:0011363)11.2535240
61Woolly hair (HP:0002224)11.0474027
62Brittle hair (HP:0002299)10.4847016
63Craniofacial dystonia (HP:0012179)1.98926256
64Abnormality of the costochondral junction (HP:0000919)1.93260466
65Pruritus (HP:0000989)1.93223638
66Difficulty walking (HP:0002355)1.89441543
67Absent phalangeal crease (HP:0006109)1.85430335
68Tinnitus (HP:0000360)1.85198965
69Conjunctival hamartoma (HP:0100780)1.84741713
70Ventricular fibrillation (HP:0001663)1.83125366
71Focal dystonia (HP:0004373)1.81987774
72Abnormality of the pupil (HP:0000615)1.80910775
73Cone-rod dystrophy (HP:0000548)1.78208927
74Constricted visual fields (HP:0001133)1.75773949
75Abnormality of the neuromuscular junction (HP:0003398)1.71277525
76Fatigable weakness (HP:0003473)1.71277525
77Abnormality of permanent molar morphology (HP:0011071)1.66919712
78Abnormality of the dental root (HP:0006486)1.66919712
79Taurodontia (HP:0000679)1.66919712
80Furrowed tongue (HP:0000221)1.66325641
81Abnormality of dental color (HP:0011073)1.65948213
82Abnormality of the nasal septum (HP:0000419)1.65766259
83Concave nail (HP:0001598)1.65075777
84Abnormality of the parietal bone (HP:0002696)1.64989041
85Abnormality of molar (HP:0011077)1.63453778
86Abnormality of molar morphology (HP:0011070)1.63453778
87Widely patent fontanelles and sutures (HP:0004492)1.61462752
88Unilateral renal agenesis (HP:0000122)1.58778200
89Severe Myopia (HP:0011003)1.57927946
90Absent eyelashes (HP:0000561)1.57042643
91Abnormality of the aortic arch (HP:0012303)1.55933742
92Recurrent corneal erosions (HP:0000495)1.55266124
93Blepharitis (HP:0000498)1.53379681
94Hyporeflexia of lower limbs (HP:0002600)1.49814100
95Sudden death (HP:0001699)1.49504064
96Morphological abnormality of the middle ear (HP:0008609)1.49108325
97Abnormal respiratory epithelium morphology (HP:0012253)1.48998969
98Abnormal respiratory motile cilium morphology (HP:0005938)1.48998969
99Progressive microcephaly (HP:0000253)1.48451186
100Pustule (HP:0200039)1.48138825
101Generalized aminoaciduria (HP:0002909)1.47039940
102Gangrene (HP:0100758)1.46032051
103Hypergammaglobulinemia (HP:0010702)1.45843013
104Abnormality of the dental pulp (HP:0006479)1.45661890
105Nonimmune hydrops fetalis (HP:0001790)1.45515979
106Mesangial abnormality (HP:0001966)1.45395234
107Acanthosis nigricans (HP:0000956)1.44889473
108Heterogeneous (HP:0001425)1.44251236
109Stenosis of the external auditory canal (HP:0000402)1.44105245
110Abnormal finger flexion creases (HP:0006143)1.43153080
111Coarse hair (HP:0002208)1.40845263
112Abnormality of placental membranes (HP:0011409)1.40690734
113Amniotic constriction ring (HP:0009775)1.40690734
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.39533768
115Carious teeth (HP:0000670)1.38941678
116Anonychia (HP:0001798)1.38578800
117Ulnar deviation of the wrist (HP:0003049)1.36434189
118Neoplasm of the adrenal cortex (HP:0100641)1.36194156
119Ectropion (HP:0000656)1.35942882
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.35699468
121Keratoconus (HP:0000563)1.35447240
122Increased corneal curvature (HP:0100692)1.35447240
123Abnormal autonomic nervous system physiology (HP:0012332)1.34720507
124Lip pit (HP:0100267)1.31533212
125Keratoconjunctivitis sicca (HP:0001097)1.31216365
126Achilles tendon contracture (HP:0001771)1.30140421
127Neonatal onset (HP:0003623)1.29836893
128Distal lower limb muscle weakness (HP:0009053)1.29242893
129Laryngomalacia (HP:0001601)1.28349509
130Delayed epiphyseal ossification (HP:0002663)1.27400349
131Autoamputation (HP:0001218)1.27282339
132Abnormality of the fingernails (HP:0001231)1.26997958
133Abnormal ciliary motility (HP:0012262)1.26566364
134Tibial bowing (HP:0002982)1.25207088
135Chest pain (HP:0100749)1.24773542
136Photophobia (HP:0000613)1.23712239
137Craniofacial hyperostosis (HP:0004493)1.23493173
138Abnormality of the Achilles tendon (HP:0005109)1.22655333
139Variable expressivity (HP:0003828)1.22497028
140Short tibia (HP:0005736)1.20340016
141Conical tooth (HP:0000698)1.18582258
142Hamartoma of the eye (HP:0010568)1.17386352
143Flat occiput (HP:0005469)1.17353872
144Selective tooth agenesis (HP:0001592)1.17187306
145Hyperhidrosis (HP:0000975)1.16498140
146Sparse scalp hair (HP:0002209)1.15293508
147Keratoconjunctivitis (HP:0001096)1.15068972
148Lack of skin elasticity (HP:0100679)1.14346851
149Abnormality of the gastric mucosa (HP:0004295)1.13486178
150Corneal dystrophy (HP:0001131)1.11630392
151Widely spaced teeth (HP:0000687)1.08907960
152Epidermoid cyst (HP:0200040)1.08018258

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB15.54810087
2NEK24.74742399
3FER4.20757305
4EPHA24.18771413
5MAPKAPK34.02474106
6ERN14.01386650
7MAP3K63.92965127
8CAMKK23.88916002
9CAMK1D3.23456641
10VRK23.17544301
11TAOK13.16570960
12EPHB23.05840235
13TRIB32.81360371
14MAP3K32.74314710
15NUAK12.67037934
16GRK12.64106412
17TAF12.59678171
18ZAK2.42641646
19MAP3K22.31681681
20CAMK1G2.29647805
21LATS12.24739118
22RPS6KB22.23024691
23MAP3K112.18248483
24MUSK2.16406995
25SMG12.10322424
26EEF2K2.02393713
27FRK1.94422777
28TTN1.76201947
29EPHB11.73600902
30WNK41.65299209
31MAP2K61.64188202
32NME11.63359162
33CSNK1G31.63255168
34PIK3CG1.60042959
35CSNK1A1L1.58882957
36LATS21.49334680
37MAPKAPK51.48268654
38TXK1.46438735
39FGFR41.37936383
40BLK1.33498332
41MAP3K11.31602090
42PIK3CA1.29031457
43MAP4K21.27514192
44BCR1.27447396
45PKN21.26307589
46MYLK1.23910956
47CSNK1G21.22928964
48CSNK1G11.21244675
49RIPK11.20509945
50BMX1.19586836
51MAP2K31.19372051
52KSR21.19354639
53CAMK11.17599369
54BMPR1B1.15178367
55DAPK11.13353499
56FGFR11.13046659
57MST1R1.11968730
58CHUK1.11494392
59MAPKAPK21.10624852
60PTK61.09796781
61GRK51.08731202
62MAPK131.07648346
63CDK61.06647224
64CDK41.01820775
65FGFR21.01761304
66PDGFRA1.01065063
67MAP3K71.01049199
68LRRK21.00974285
69ABL21.00404997
70TESK20.97823289
71FGFR30.96893877
72MAP3K90.96736796
73CASK0.95560664
74BCKDK0.94523116
75ADRBK20.91279426
76TRIM280.88833214
77WNK30.86166239
78PRKCE0.85120220
79PTK20.83984648
80SIK10.83692113
81MAP3K40.83321061
82MAP2K40.80599386
83MAP2K10.79837688
84MAPK40.79186526
85RPS6KA40.78057362
86PAK40.74553398
87CHEK20.74469331
88KDR0.74232931
89TAOK30.73579277
90MAP3K100.73467297
91MARK10.72950251
92PBK0.72674689
93PIM20.72608498
94TESK10.72127886
95PAK30.69519158
96STK380.68398014
97CAMKK10.67384530
98PRKD10.66977321
99STK390.66373269
100DYRK1B0.65831383
101MET0.64692990
102CDK190.64360602
103DDR20.61331566
104CDK120.60812920
105ADRBK10.58597986
106PRKD20.57906370
107PLK20.56105392
108INSRR0.56046735
109TYK20.55631639
110TRPM70.55536086
111PRKCH0.55141240
112HIPK20.55074054
113JAK10.54692646
114PRKCI0.53999968
115PAK60.53160012
116STK38L0.52919432
117CAMK2B0.52849900
118MAP3K50.51897555
119MAP2K70.51821641
120TYRO30.51349202
121PAK20.51263575
122NTRK20.49473433
123RET0.48711011
124ERBB40.48576603
125EPHA30.48469118
126RPS6KA10.46166887
127ERBB20.46163605
128VRK10.45981809
129ALK0.45813030
130SYK0.44760734
131PRKAA20.44036610
132PRKCA0.43973414
133MAPK120.43641836
134MST40.43589028
135CLK10.43110581
136MAP2K20.42541200
137MAP3K120.42011843
138TGFBR10.41949947
139GRK60.41713481
140PRKCZ0.40560130
141OBSCN0.39837564
142GSK3A0.38285938
143NEK10.37989685
144CSNK1E0.36980180
145AKT30.36439104
146NTRK30.35594343
147JAK20.34930065
148DYRK20.34725384
149MAP3K80.34670686
150CAMK40.34211045
151EPHA40.33953587
152STK240.33181907
153PRKCG0.33169346
154FYN0.33144726
155ILK0.32636122
156RPS6KB10.28745240
157MARK20.28096613
158HCK0.27995274
159LIMK10.27724384
160PRKACA0.27677863
161MAP4K10.26767218
162IGF1R0.26235074
163TGFBR20.25336070
164SRC0.25312848
165CSNK1A10.25281287
166ICK0.25149790
167TNIK0.24829495
168STK110.21674506
169PRKACG0.20940478
170ROCK20.20622622
171MATK0.20471475

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.25131983
2Linoleic acid metabolism_Homo sapiens_hsa005915.20953204
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.65201892
4Fat digestion and absorption_Homo sapiens_hsa049753.54300196
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.07758840
6Retinol metabolism_Homo sapiens_hsa008303.04211333
7Ether lipid metabolism_Homo sapiens_hsa005652.76807080
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.76149851
9Fatty acid elongation_Homo sapiens_hsa000622.69292708
10Sulfur metabolism_Homo sapiens_hsa009202.67571470
11Vitamin digestion and absorption_Homo sapiens_hsa049772.35131949
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.31038355
13Arachidonic acid metabolism_Homo sapiens_hsa005902.08494317
14Starch and sucrose metabolism_Homo sapiens_hsa005002.06305165
15Basal cell carcinoma_Homo sapiens_hsa052171.98678072
16Phenylalanine metabolism_Homo sapiens_hsa003601.85942199
17Fatty acid biosynthesis_Homo sapiens_hsa000611.85783242
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80649930
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.79698959
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.75987137
21Glycerolipid metabolism_Homo sapiens_hsa005611.69213155
22VEGF signaling pathway_Homo sapiens_hsa043701.63461508
23Renin-angiotensin system_Homo sapiens_hsa046141.52626098
24Melanogenesis_Homo sapiens_hsa049161.45681260
25Sphingolipid metabolism_Homo sapiens_hsa006001.45482695
26Caffeine metabolism_Homo sapiens_hsa002321.44319238
27Axon guidance_Homo sapiens_hsa043601.43652424
28Tryptophan metabolism_Homo sapiens_hsa003801.38785249
29Histidine metabolism_Homo sapiens_hsa003401.35822828
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.34088353
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30408306
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29675596
33Nicotine addiction_Homo sapiens_hsa050331.29039859
34Glioma_Homo sapiens_hsa052141.27710664
35Thyroid cancer_Homo sapiens_hsa052161.23913370
36Bladder cancer_Homo sapiens_hsa052191.22210960
37Hedgehog signaling pathway_Homo sapiens_hsa043401.21348367
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.18001875
39Pancreatic secretion_Homo sapiens_hsa049721.17757359
40Acute myeloid leukemia_Homo sapiens_hsa052211.17681043
41Proteoglycans in cancer_Homo sapiens_hsa052051.17275220
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16939905
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16529805
44GnRH signaling pathway_Homo sapiens_hsa049121.16306127
45PPAR signaling pathway_Homo sapiens_hsa033201.14951650
46Arginine and proline metabolism_Homo sapiens_hsa003301.12699781
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09824070
48Peroxisome_Homo sapiens_hsa041461.08551438
49Hippo signaling pathway_Homo sapiens_hsa043901.08003379
50Lysosome_Homo sapiens_hsa041421.07310278
51Tight junction_Homo sapiens_hsa045301.04823509
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02611749
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.02261959
54Mineral absorption_Homo sapiens_hsa049781.00724160
55Dorso-ventral axis formation_Homo sapiens_hsa043201.00226876
56Steroid biosynthesis_Homo sapiens_hsa001001.00118183
57Sulfur relay system_Homo sapiens_hsa041220.98501478
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97127750
59Nitrogen metabolism_Homo sapiens_hsa009100.96413624
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95277606
61Long-term potentiation_Homo sapiens_hsa047200.93634760
62Tyrosine metabolism_Homo sapiens_hsa003500.91875844
63Adherens junction_Homo sapiens_hsa045200.86464946
64ECM-receptor interaction_Homo sapiens_hsa045120.86028734
65Pertussis_Homo sapiens_hsa051330.85657636
66Synaptic vesicle cycle_Homo sapiens_hsa047210.84980883
67Taste transduction_Homo sapiens_hsa047420.84894948
68Ras signaling pathway_Homo sapiens_hsa040140.82853465
69Non-small cell lung cancer_Homo sapiens_hsa052230.80874688
70beta-Alanine metabolism_Homo sapiens_hsa004100.80778431
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79473030
72Estrogen signaling pathway_Homo sapiens_hsa049150.79190438
73Propanoate metabolism_Homo sapiens_hsa006400.78759924
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78432218
75Endometrial cancer_Homo sapiens_hsa052130.77205663
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.77153966
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74859370
78ABC transporters_Homo sapiens_hsa020100.74665671
79Long-term depression_Homo sapiens_hsa047300.74531734
80Lysine degradation_Homo sapiens_hsa003100.73374309
81Amoebiasis_Homo sapiens_hsa051460.72813515
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72752693
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.72620989
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71349349
85Collecting duct acid secretion_Homo sapiens_hsa049660.70472202
86Staphylococcus aureus infection_Homo sapiens_hsa051500.69897721
87Gastric acid secretion_Homo sapiens_hsa049710.67063452
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64101439
89Wnt signaling pathway_Homo sapiens_hsa043100.63573947
90Renin secretion_Homo sapiens_hsa049240.62808330
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61637503
92Phototransduction_Homo sapiens_hsa047440.60750098
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59605097
94Hepatitis C_Homo sapiens_hsa051600.59291854
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.58865683
96Salivary secretion_Homo sapiens_hsa049700.57029172
97Calcium signaling pathway_Homo sapiens_hsa040200.57029062
98Ovarian steroidogenesis_Homo sapiens_hsa049130.55971281
99Insulin resistance_Homo sapiens_hsa049310.55539401
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55140408
101Homologous recombination_Homo sapiens_hsa034400.54464286
102Fatty acid metabolism_Homo sapiens_hsa012120.54419748
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.53451988
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52667017
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.52195000
106Salmonella infection_Homo sapiens_hsa051320.52031013
107Circadian entrainment_Homo sapiens_hsa047130.51193824
108Glutathione metabolism_Homo sapiens_hsa004800.50868399
109Gap junction_Homo sapiens_hsa045400.50787026
110MicroRNAs in cancer_Homo sapiens_hsa052060.50744067
111Rap1 signaling pathway_Homo sapiens_hsa040150.50481048
112Metabolic pathways_Homo sapiens_hsa011000.49582408
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48834865
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46934958
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46281158
116Fatty acid degradation_Homo sapiens_hsa000710.45762174
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45545020
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45532366
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.44849633
120Chemical carcinogenesis_Homo sapiens_hsa052040.44484469
121Oxytocin signaling pathway_Homo sapiens_hsa049210.43779318
122Renal cell carcinoma_Homo sapiens_hsa052110.43283107
123Butanoate metabolism_Homo sapiens_hsa006500.42706552
124Focal adhesion_Homo sapiens_hsa045100.42260170
125ErbB signaling pathway_Homo sapiens_hsa040120.42236052
126Pyruvate metabolism_Homo sapiens_hsa006200.41655752
127Oxidative phosphorylation_Homo sapiens_hsa001900.41428262
128Platelet activation_Homo sapiens_hsa046110.40831801
129Complement and coagulation cascades_Homo sapiens_hsa046100.40389437
130Protein digestion and absorption_Homo sapiens_hsa049740.40017029
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38669558
132Olfactory transduction_Homo sapiens_hsa047400.38621737
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38553729
134Tuberculosis_Homo sapiens_hsa051520.37828009
135Toxoplasmosis_Homo sapiens_hsa051450.37180607
136Bile secretion_Homo sapiens_hsa049760.37098611
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36770401
138Glutamatergic synapse_Homo sapiens_hsa047240.36694745
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36682205
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36316195
141Prion diseases_Homo sapiens_hsa050200.35984039
142Rheumatoid arthritis_Homo sapiens_hsa053230.35005365
143Arginine biosynthesis_Homo sapiens_hsa002200.34614450
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34329958
145Prolactin signaling pathway_Homo sapiens_hsa049170.34309060
146TGF-beta signaling pathway_Homo sapiens_hsa043500.33730786
147Insulin signaling pathway_Homo sapiens_hsa049100.33573833
148Chronic myeloid leukemia_Homo sapiens_hsa052200.33192804
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32100148
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.29569802
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26099652
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25956025
153Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22113886
154cAMP signaling pathway_Homo sapiens_hsa040240.20412803
155Dopaminergic synapse_Homo sapiens_hsa047280.20166268
156Serotonergic synapse_Homo sapiens_hsa047260.17526205
157Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17172152
158Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16689660
159Alzheimers disease_Homo sapiens_hsa050100.13153088
160Amphetamine addiction_Homo sapiens_hsa050310.12497019

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