ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	9.04360843
2	adhesion of symbiont to host (GO:0044406)	8.65318764
3	peptide cross-linking (GO:0018149)	8.50490393
4	hair follicle morphogenesis (GO:0031069)	8.21417258
5	intermediate filament cytoskeleton organization (GO:0045104)	6.80741531
6	intermediate filament-based process (GO:0045103)	6.59143959
7	epidermis development (GO:0008544)	6.09394983
8	citrulline metabolic process (GO:0000052)	5.99422800
9	cell wall macromolecule catabolic process (GO:0016998)	5.91714157
10	cell wall macromolecule metabolic process (GO:0044036)	5.91714157
11	keratinocyte differentiation (GO:0030216)	5.82744942
12	establishment of skin barrier (GO:0061436)	5.71803909
13	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.31144101
14	hair cycle process (GO:0022405)	5.27588434
15	molting cycle process (GO:0022404)	5.27588434
16	regulation of water loss via skin (GO:0033561)	5.06879558
17	hemidesmosome assembly (GO:0031581)	5.05662133
18	peptidyl-arginine modification (GO:0018195)	5.00213378
19	skin morphogenesis (GO:0043589)	4.98177737
20	epidermal cell differentiation (GO:0009913)	4.53455708
21	molting cycle (GO:0042303)	35.0447251
22	hair cycle (GO:0042633)	35.0447251
23	keratinocyte development (GO:0003334)	3.76516480
24	tooth mineralization (GO:0034505)	3.74104257
25	multicellular organismal water homeostasis (GO:0050891)	3.41322391
26	negative regulation of keratinocyte proliferation (GO:0010839)	3.35777057
27	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.31315170
28	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.25634305
29	positive regulation of hair cycle (GO:0042635)	3.10694661
30	positive regulation of hair follicle development (GO:0051798)	3.10694661
31	regulation of keratinocyte differentiation (GO:0045616)	3.10341936
32	hair follicle development (GO:0001942)	3.10113943
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.03536801
34	regulation of hair follicle development (GO:0051797)	2.92430130
35	ectoderm development (GO:0007398)	2.92262146
36	epithelium development (GO:0060429)	2.87948377
37	water homeostasis (GO:0030104)	2.79474154
38	gap junction assembly (GO:0016264)	2.77012667
39	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.76605816
40	fatty acid elongation (GO:0030497)	2.72480494
41	negative regulation of protein localization to plasma membrane (GO:1903077)	2.69922678
42	atrioventricular valve morphogenesis (GO:0003181)	2.68861284
43	positive regulation of epidermis development (GO:0045684)	2.68501211
44	bone trabecula formation (GO:0060346)	2.66526736
45	regulation of hair cycle (GO:0042634)	2.61702465
46	positive regulation of meiotic cell cycle (GO:0051446)	2.55875947
47	ventricular cardiac muscle cell action potential (GO:0086005)	2.46139378
48	regulation of epidermal cell differentiation (GO:0045604)	2.44172164
49	regulation of epidermis development (GO:0045682)	2.38747297
50	negative regulation of cell fate specification (GO:0009996)	2.35169238
51	phosphatidylserine metabolic process (GO:0006658)	2.29687028
52	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.27267679
53	positive regulation of epidermal cell differentiation (GO:0045606)	2.22054106
54	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.21052394
55	lymph vessel development (GO:0001945)	2.20504352
56	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.16300214
57	skin development (GO:0043588)	2.16148542
58	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.14172237
59	positive regulation of monocyte chemotaxis (GO:0090026)	2.10511270
60	regulation of cardioblast differentiation (GO:0051890)	2.09211315
61	wound healing, spreading of epidermal cells (GO:0035313)	2.07503391
62	aging (GO:0007568)	2.06642141
63	regulation of heart rate by cardiac conduction (GO:0086091)	2.05852550
64	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.04997248
65	epithelial cell-cell adhesion (GO:0090136)	2.03583065
66	intermediate filament organization (GO:0045109)	12.3454395
67	keratinization (GO:0031424)	11.6406872
68	virion attachment to host cell (GO:0019062)	10.2359713
69	adhesion of symbiont to host cell (GO:0044650)	10.2359713
70	desmosome organization (GO:0002934)	10.2217835
71	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.97073786
72	cranial suture morphogenesis (GO:0060363)	1.95302964
73	myotube differentiation (GO:0014902)	1.95182998
74	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.95155468
75	cell communication involved in cardiac conduction (GO:0086065)	1.95114604
76	regulation of ruffle assembly (GO:1900027)	1.91519230
77	outflow tract septum morphogenesis (GO:0003148)	1.91001979
78	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.88892182
79	regulation of keratinocyte proliferation (GO:0010837)	1.86712892
80	cell-substrate junction assembly (GO:0007044)	1.84195624
81	negative regulation of epidermis development (GO:0045683)	1.84091669
82	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.83729183
83	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.83729183
84	ephrin receptor signaling pathway (GO:0048013)	1.78720520
85	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.74041810
86	non-canonical Wnt signaling pathway (GO:0035567)	1.72846151
87	coronary vasculature morphogenesis (GO:0060977)	1.72237296
88	alditol phosphate metabolic process (GO:0052646)	1.69962552
89	regulation of cardioblast proliferation (GO:0003264)	1.68128474
90	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.68128474
91	very long-chain fatty acid metabolic process (GO:0000038)	1.66890660
92	primary alcohol catabolic process (GO:0034310)	1.65171408
93	negative regulation of cell fate commitment (GO:0010454)	1.61563703
94	cardiac conduction (GO:0061337)	1.60919849
95	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.60106804
96	cardiac muscle cell action potential involved in contraction (GO:0086002)	1.55957822
97	cellular modified amino acid biosynthetic process (GO:0042398)	1.55880761
98	regulation of transforming growth factor beta2 production (GO:0032909)	1.55497742
99	establishment of planar polarity (GO:0001736)	1.55115345
100	establishment of tissue polarity (GO:0007164)	1.55115345

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.21952590
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.78247274
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.54795629
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.68515671
5	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.17926981
6	* CTCF_20526341_ChIP-Seq_ESCs_Human	2.17899702
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.16707771
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.8192706
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.93410057
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.86325595
11	EGR1_19032775_ChIP-ChIP_M12_Human	1.77901710
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.72893084
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.72705532
14	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.72089131
15	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.69107651
16	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.66996637
17	CTCF_27219007_Chip-Seq_Bcells_Human	1.60719298
18	ERG_20517297_ChIP-Seq_VCAP_Human	1.58624326
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.58597882
20	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.55188611
21	P53_21459846_ChIP-Seq_SAOS-2_Human	1.55004837
22	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.53842201
23	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.53184487
24	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.53184487
25	LXR_22292898_ChIP-Seq_THP-1_Human	1.52300821
26	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51880059
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.49997829
28	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.49856752
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49612644
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.47292221
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.42559427
32	ATF3_27146783_Chip-Seq_COLON_Human	1.39865738
33	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.37776088
34	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.37580879
35	* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.37010433
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36956381
37	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.35262252
38	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28040076
39	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.28003610
40	PHF8_20622854_ChIP-Seq_HELA_Human	1.25813739
41	* BCOR_27268052_Chip-Seq_Bcells_Human	1.23875877
42	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.23560945
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.21045473
44	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.20879454
45	P68_20966046_ChIP-Seq_HELA_Human	1.18529830
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18514899
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17683533
48	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16645801
49	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.16029106
50	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.15514703
51	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14642495
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.14448755
53	RAC3_21632823_ChIP-Seq_H3396_Human	1.12770549
54	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12570974
55	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11403385
56	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.11360796
57	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.08451929
58	TP63_23658742_ChIP-Seq_EP156T_Human	1.07599514
59	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.07238823
60	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07178298
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06882356
62	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.06554538
63	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.06493073
64	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.05459120
65	SPI1_20517297_ChIP-Seq_HL60_Human	1.01901861
66	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.01427335
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00118061
68	SOX2_21211035_ChIP-Seq_LN229_Human	0.99041379
69	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98511050
70	* SMC4_20622854_ChIP-Seq_HELA_Human	0.95977150
71	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.95796146
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.94764451
73	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.94302870
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.94144062
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92208926
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.90659290
77	* GATA4_25053715_ChIP-Seq_YYC3_Human	0.90149740
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90046360
79	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.89441026
80	TP53_18474530_ChIP-ChIP_U2OS_Human	0.88964978
81	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.87738658
82	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.87002152
83	RXR_22108803_ChIP-Seq_LS180_Human	0.86488950
84	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.86473366
85	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.86280019
86	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.85558809
87	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.84373642
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.84330093
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83519292
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.81165279
91	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80603161
92	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.79341367
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78920434
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.78185240
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.76715376
96	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74910818
97	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.74057004
98	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.73993146
99	AR_21572438_ChIP-Seq_LNCaP_Human	0.73333014
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.73022507

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.82848940
2	MP0002098_abnormal_vibrissa_morphology	7.08374405
3	MP0000647_abnormal_sebaceous_gland	6.38125409
4	MP0002796_impaired_skin_barrier	5.95369051
5	MP0005275_abnormal_skin_tensile	5.14520696
6	MP0010234_abnormal_vibrissa_follicle	5.06985830
7	MP0000383_abnormal_hair_follicle	4.53424044
8	MP0000377_abnormal_hair_follicle	4.06961315
9	MP0010678_abnormal_skin_adnexa	4.01843155
10	MP0003705_abnormal_hypodermis_morpholog	3.78379742
11	MP0005501_abnormal_skin_physiology	3.74335558
12	MP0000427_abnormal_hair_cycle	3.46084257
13	MP0002254_reproductive_system_inflammat	2.92264629
14	MP0001216_abnormal_epidermal_layer	2.68861379
15	MP0004381_abnormal_hair_follicle	2.63627225
16	MP0000367_abnormal_coat/_hair	2.35521455
17	MP0004947_skin_inflammation	2.32645708
18	MP0010771_integument_phenotype	2.30482553
19	MP0003453_abnormal_keratinocyte_physiol	2.21766433
20	MP0002060_abnormal_skin_morphology	2.14722422
21	MP0001243_abnormal_dermal_layer	2.12163701
22	MP0002234_abnormal_pharynx_morphology	2.06020174
23	MP0000467_abnormal_esophagus_morphology	1.88070954
24	MP0000762_abnormal_tongue_morphology	1.52292249
25	MP0009053_abnormal_anal_canal	1.50639512
26	MP0009931_abnormal_skin_appearance	1.49608233
27	MP0003566_abnormal_cell_adhesion	1.47962080
28	MP0005409_darkened_coat_color	1.43136665
29	MP0003941_abnormal_skin_development	1.15365863
30	MP0001191_abnormal_skin_condition	0.99872973
31	MP0004885_abnormal_endolymph	0.94619354
32	MP0004185_abnormal_adipocyte_glucose	0.88730408
33	MP0001851_eye_inflammation	0.85258012
34	MP0004264_abnormal_extraembryonic_tissu	0.84772155
35	MP0002095_abnormal_skin_pigmentation	0.77572176
36	MP0001849_ear_inflammation	0.69221511
37	MP0003315_abnormal_perineum_morphology	0.67903170
38	MP0008438_abnormal_cutaneous_collagen	0.66812721
39	MP0001340_abnormal_eyelid_morphology	0.63221389
40	MP0002877_abnormal_melanocyte_morpholog	0.61930649
41	MP0001346_abnormal_lacrimal_gland	0.60962846
42	MP0001661_extended_life_span	0.60326917
43	MP0003191_abnormal_cellular_cholesterol	0.57479978
44	MP0010030_abnormal_orbit_morphology	0.55904765
45	MP0005451_abnormal_body_composition	0.55888826
46	MP0000627_abnormal_mammary_gland	0.54578986
47	MP0002282_abnormal_trachea_morphology	0.53939368
48	MP0000566_synostosis	0.52443758
49	MP0005023_abnormal_wound_healing	0.51358696
50	MP0003755_abnormal_palate_morphology	0.49933688
51	MP0002970_abnormal_white_adipose	0.46783487
52	MP0001784_abnormal_fluid_regulation	0.45505983
53	MP0002249_abnormal_larynx_morphology	0.39693123
54	MP0000678_abnormal_parathyroid_gland	0.38678821
55	MP0002111_abnormal_tail_morphology	0.38488732
56	MP0005075_abnormal_melanosome_morpholog	0.36495889
57	MP0009840_abnormal_foam_cell	0.34684129
58	MP0010352_gastrointestinal_tract_polyps	0.33136983
59	MP0004272_abnormal_basement_membrane	0.32874851
60	MP0003385_abnormal_body_wall	0.29091081
61	MP0000537_abnormal_urethra_morphology	0.27984682
62	MP0000465_gastrointestinal_hemorrhage	0.27858318
63	MP0003329_amyloid_beta_deposits	0.26995496
64	MP0002177_abnormal_outer_ear	0.26706180
65	MP0003950_abnormal_plasma_membrane	0.26466175
66	MP0003763_abnormal_thymus_physiology	0.26009981
67	MP0002697_abnormal_eye_size	0.23692602
68	MP0005248_abnormal_Harderian_gland	0.21904866
69	MP0003300_gastrointestinal_ulcer	0.21829512
70	MP0004019_abnormal_vitamin_homeostasis	0.20744429
71	MP0006054_spinal_hemorrhage	0.18734691
72	MP0004742_abnormal_vestibular_system	0.18141600
73	MP0001879_abnormal_lymphatic_vessel	0.18033394
74	MP0003448_altered_tumor_morphology	0.15958447
75	MP0000432_abnormal_head_morphology	0.15874357
76	MP0003011_delayed_dark_adaptation	0.15501489
77	MP0005666_abnormal_adipose_tissue	0.15339056
78	MP0004858_abnormal_nervous_system	0.15216820
79	MP0000604_amyloidosis	0.14705679
80	MP0005375_adipose_tissue_phenotype	0.14513832
81	MP0003935_abnormal_craniofacial_develop	0.13557798
82	MP0003638_abnormal_response/metabolism_	0.12933602
83	MP0003075_altered_response_to	0.11939531
84	MP0005076_abnormal_cell_differentiation	0.11044236
85	MP0005367_renal/urinary_system_phenotyp	0.10894072
86	MP0000516_abnormal_urinary_system	0.10894072
87	MP0005193_abnormal_anterior_eye	0.10389739
88	MP0002233_abnormal_nose_morphology	0.10217697
89	MP0010368_abnormal_lymphatic_system	0.08980408
90	MP0002006_tumorigenesis	0.08952317
91	MP0003045_fibrosis	0.08410566
92	MP0008569_lethality_at_weaning	0.08022110
93	MP0000462_abnormal_digestive_system	0.08021603
94	MP0000733_abnormal_muscle_development	0.07779378
95	MP0002166_altered_tumor_susceptibility	0.07774263
96	MP0001958_emphysema	0.07251678
97	MP0006138_congestive_heart_failure	0.06104081
98	MP0002090_abnormal_vision	0.06031332
99	MP0000013_abnormal_adipose_tissue	0.06014184
100	MP0005165_increased_susceptibility_to	0.05131442

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.11379058
2	Nail dystrophy (HP:0008404)	7.28717122
3	Abnormality of nail color (HP:0100643)	6.84543612
4	Abnormal hair laboratory examination (HP:0003328)	5.76167600
5	Fragile nails (HP:0001808)	5.62961554
6	Fine hair (HP:0002213)	5.15322385
7	Alopecia of scalp (HP:0002293)	5.14326684
8	Palmoplantar hyperkeratosis (HP:0000972)	5.10667331
9	Onycholysis (HP:0001806)	5.02892768
10	Thick nail (HP:0001805)	4.99255713
11	Increased IgE level (HP:0003212)	4.92342105
12	Palmar hyperkeratosis (HP:0010765)	4.80838092
13	Plantar hyperkeratosis (HP:0007556)	4.62936246
14	Follicular hyperkeratosis (HP:0007502)	4.52499506
15	Right ventricular cardiomyopathy (HP:0011663)	4.33323955
16	Oral leukoplakia (HP:0002745)	3.71945695
17	Erythema (HP:0010783)	3.65011819
18	Sparse eyelashes (HP:0000653)	3.59258228
19	Milia (HP:0001056)	3.34243392
20	Amelogenesis imperfecta (HP:0000705)	3.05242227
21	Erythroderma (HP:0001019)	3.00402471
22	Abnormality of the frontal sinuses (HP:0002687)	2.99927529
23	Parakeratosis (HP:0001036)	2.88371011
24	Ridged nail (HP:0001807)	2.79571208
25	Curly hair (HP:0002212)	2.71723383
26	Intention tremor (HP:0002080)	2.66971627
27	Congenital, generalized hypertrichosis (HP:0004540)	2.58777050
28	Abnormal blistering of the skin (HP:0008066)	2.57823125
29	Natal tooth (HP:0000695)	2.47989337
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.43269437
31	Neck muscle weakness (HP:0000467)	2.43014800
32	Advanced eruption of teeth (HP:0006288)	2.38728015
33	Torticollis (HP:0000473)	2.36769896
34	Aplasia cutis congenita (HP:0001057)	2.35716580
35	Dry hair (HP:0011359)	2.34300777
36	Hypohidrosis (HP:0000966)	2.15514160
37	Palmoplantar keratoderma (HP:0000982)	2.09328752
38	Corneal erosion (HP:0200020)	2.08508901
39	Ventricular tachycardia (HP:0004756)	2.06569194
40	Craniofacial dystonia (HP:0012179)	2.00043405
41	Hypotrichosis (HP:0001006)	14.5350421
42	Woolly hair (HP:0002224)	11.1429385
43	Slow-growing hair (HP:0002217)	10.9028706
44	Abnormality of hair growth rate (HP:0011363)	10.9028706
45	Brittle hair (HP:0002299)	10.0632952
46	Pruritus (HP:0000989)	1.94942381
47	Difficulty walking (HP:0002355)	1.90226604
48	Ventricular fibrillation (HP:0001663)	1.86607060
49	Focal dystonia (HP:0004373)	1.82986672
50	Abnormality of the pupil (HP:0000615)	1.80601306
51	Abnormality of the neuromuscular junction (HP:0003398)	1.78052464
52	Fatigable weakness (HP:0003473)	1.78052464
53	Abnormality of the dental root (HP:0006486)	1.70246577
54	Taurodontia (HP:0000679)	1.70246577
55	Abnormality of permanent molar morphology (HP:0011071)	1.70246577
56	Conjunctival hamartoma (HP:0100780)	1.70074650
57	Abnormality of dental color (HP:0011073)	1.67799396
58	Abnormality of molar morphology (HP:0011070)	1.67247870
59	Abnormality of molar (HP:0011077)	1.67247870
60	Abnormality of the parietal bone (HP:0002696)	1.66762564
61	Concave nail (HP:0001598)	1.65815663
62	Absent eyelashes (HP:0000561)	1.62974478
63	Recurrent corneal erosions (HP:0000495)	1.61448565
64	Widely patent fontanelles and sutures (HP:0004492)	1.60843102
65	Blepharitis (HP:0000498)	1.58331726
66	Unilateral renal agenesis (HP:0000122)	1.55477790
67	Abnormality of the aortic arch (HP:0012303)	1.50978399
68	Sudden death (HP:0001699)	1.49419439
69	Hyporeflexia of lower limbs (HP:0002600)	1.49186421
70	Anonychia (HP:0001798)	1.48724518
71	Abnormality of the dental pulp (HP:0006479)	1.48594086
72	Amniotic constriction ring (HP:0009775)	1.47971544
73	Abnormality of placental membranes (HP:0011409)	1.47971544
74	Carious teeth (HP:0000670)	1.47120064
75	Hypergammaglobulinemia (HP:0010702)	1.46097032
76	Acanthosis nigricans (HP:0000956)	1.45203781
77	Laryngomalacia (HP:0001601)	1.42237308
78	Gangrene (HP:0100758)	1.40509154
79	Heterogeneous (HP:0001425)	1.40354108
80	Lip pit (HP:0100267)	1.37259091
81	Ectropion (HP:0000656)	1.36255453
82	Keratoconjunctivitis sicca (HP:0001097)	1.35901293
83	Neonatal onset (HP:0003623)	1.33168306
84	Abnormality of the fingernails (HP:0001231)	1.32591522
85	Autoamputation (HP:0001218)	1.31866593
86	Achilles tendon contracture (HP:0001771)	1.29801410
87	Craniofacial hyperostosis (HP:0004493)	1.26942920
88	Distal lower limb muscle weakness (HP:0009053)	1.25277543
89	Hyperhidrosis (HP:0000975)	1.22791374
90	Corneal dystrophy (HP:0001131)	1.22743330
91	Abnormality of the Achilles tendon (HP:0005109)	1.22221210
92	Keratoconjunctivitis (HP:0001096)	1.19359613
93	Sparse scalp hair (HP:0002209)	1.17514885
94	Selective tooth agenesis (HP:0001592)	1.17348185
95	Variable expressivity (HP:0003828)	1.16924172
96	Atrophic scars (HP:0001075)	1.14326687
97	Abnormality of the gastric mucosa (HP:0004295)	1.14312590
98	Lack of skin elasticity (HP:0100679)	1.13857991
99	Widely spaced teeth (HP:0000687)	1.12309322
100	Skin ulcer (HP:0200042)	1.11120307

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.34528697
2	EPHA2	4.23547912
3	ERN1	3.98130277
4	MAPKAPK3	3.96977427
5	MAP3K6	3.89007822
6	EPHB2	3.08498805
7	TAOK1	3.08300851
8	TRIB3	2.76580125
9	MAP3K3	2.71125052
10	MAP3K2	2.32252012
11	LATS1	2.23982533
12	MAP3K11	2.10389769
13	RPS6KB2	1.92603680
14	EEF2K	1.92098451
15	EPHB1	1.82850551
16	TTN	1.70325528
17	PIK3CG	1.66595884
18	MAP2K6	1.63409881
19	LATS2	1.55352786
20	FGFR4	1.49796235
21	BCR	1.36285328
22	MAP3K1	1.31878439
23	NME1	1.26754299
24	RIPK1	1.26559031
25	PKN2	1.24797901
26	BMX	1.23828687
27	BLK	1.23205583
28	KSR2	1.18106320
29	MST1R	1.17818644
30	MAP2K3	1.14394075
31	CDK6	1.11720665
32	FGFR1	1.11292470
33	FGFR3	1.09627342
34	MAPKAPK2	1.09295488
35	PDGFRA	1.08278592
36	FGFR2	1.08266252
37	PTK6	1.02797482
38	MAP3K9	0.99882314
39	LRRK2	0.99865934
40	MAP3K7	0.97133436
41	RPS6KA4	0.87264960
42	SIK1	0.86975061
43	PTK2	0.85694202
44	MAP2K4	0.82613987
45	PBK	0.79658008
46	MAP2K1	0.75920140
47	STK38	0.72885398
48	PAK4	0.72443147
49	MAP3K10	0.71830796
50	TESK1	0.70866750
51	MET	0.70225931
52	PIM2	0.70179074
53	PAK3	0.69245863
54	PRKD1	0.68054828
55	TYK2	0.66915329
56	DDR2	0.66075060
57	DYRK1B	0.64812118
58	CDK19	0.63179021
59	JAK1	0.61926001
60	STK38L	0.58181146
61	EPHA3	0.57505617
62	PRKCH	0.55439009
63	PRKCI	0.54792456
64	TYRO3	0.54401722
65	TRPM7	0.54395805
66	PAK2	0.54094763
67	NTRK2	0.54066254
68	PAK6	0.52386526
69	RET	0.52218790
70	MAP3K5	0.52174257
71	ERBB4	0.50680232
72	OBSCN	0.49834019
73	ERBB2	0.48088337
74	TGFBR1	0.47810049
75	ALK	0.47070405
76	RPS6KA1	0.46690406
77	MAPK12	0.44549638
78	CLK1	0.41318169
79	GSK3A	0.39816432
80	CSNK1E	0.37869101
81	JAK2	0.37674509
82	GRK6	0.37426349
83	MST4	0.36426251
84	NEK1	0.35868144
85	MAP2K2	0.35097561
86	FYN	0.33452155
87	MAP3K8	0.32465881
88	TGFBR2	0.31205310
89	LIMK1	0.28252488
90	HCK	0.26713019
91	ILK	0.25833050
92	SRC	0.25725548
93	MAP4K1	0.24302928
94	CSNK1A1	0.24159585
95	STK11	0.23757439
96	PRKACG	0.22479493
97	MATK	0.21807352
98	NTRK1	0.21544927
99	ROCK2	0.21036625
100	MAPK8	0.21027971

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.93521714
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.88323779
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.23456482
4	Fatty acid elongation_Homo sapiens_hsa00062	2.89261684
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.58344085
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.11139005
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.88543881
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.86780095
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.85804532
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.83822540
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.67711750
12	Caffeine metabolism_Homo sapiens_hsa00232	1.53486445
13	Axon guidance_Homo sapiens_hsa04360	1.51282135
14	Melanogenesis_Homo sapiens_hsa04916	1.51036128
15	Histidine metabolism_Homo sapiens_hsa00340	1.36642363
16	Glioma_Homo sapiens_hsa05214	1.30197117
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.29247245
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.28622641
19	Bladder cancer_Homo sapiens_hsa05219	1.26729678
20	Thyroid cancer_Homo sapiens_hsa05216	1.26030868
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.24091956
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.23796182
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.19016925
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.16883231
25	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14051820
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.12440610
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.10599265
28	Pancreatic secretion_Homo sapiens_hsa04972	1.09847343
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08288255
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.07714364
31	Tight junction_Homo sapiens_hsa04530	1.07235645
32	Mineral absorption_Homo sapiens_hsa04978	1.04943202
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.02085099
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.96769862
35	ECM-receptor interaction_Homo sapiens_hsa04512	0.95868683
36	Long-term potentiation_Homo sapiens_hsa04720	0.95813504
37	Adherens junction_Homo sapiens_hsa04520	0.95326605
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.94126209
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.89918577
40	Pertussis_Homo sapiens_hsa05133	0.87822417
41	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.84818295
42	Non-small cell lung cancer_Homo sapiens_hsa05223	0.83459853
43	Endometrial cancer_Homo sapiens_hsa05213	0.82018384
44	Ras signaling pathway_Homo sapiens_hsa04014	0.81316755
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81185662
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.80510081
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.78517590
48	Long-term depression_Homo sapiens_hsa04730	0.78500135
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.77052455
50	Amoebiasis_Homo sapiens_hsa05146	0.76754635
51	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74495482
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.74201868
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.72011295
54	Wnt signaling pathway_Homo sapiens_hsa04310	0.69895049
55	Gastric acid secretion_Homo sapiens_hsa04971	0.67659968
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67059198
57	Renin secretion_Homo sapiens_hsa04924	0.62136255
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.61826845
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61740948
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60430515
61	Hepatitis C_Homo sapiens_hsa05160	0.59474343
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.59272344
63	Insulin resistance_Homo sapiens_hsa04931	0.58645255
64	Phototransduction_Homo sapiens_hsa04744	0.58324783
65	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.58112046
66	MicroRNAs in cancer_Homo sapiens_hsa05206	0.56414236
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.54947980
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53871825
69	Salmonella infection_Homo sapiens_hsa05132	0.53773482
70	Gap junction_Homo sapiens_hsa04540	0.52594083
71	Salivary secretion_Homo sapiens_hsa04970	0.50858194
72	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.49800393
73	Focal adhesion_Homo sapiens_hsa04510	0.48307635
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47289333
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.46927014
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.46598004
77	Platelet activation_Homo sapiens_hsa04611	0.46094709
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45424483
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45306462
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.45020088
81	Fatty acid degradation_Homo sapiens_hsa00071	0.44567766
82	Protein digestion and absorption_Homo sapiens_hsa04974	0.43586550
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42289277
84	Toxoplasmosis_Homo sapiens_hsa05145	0.42245220
85	Butanoate metabolism_Homo sapiens_hsa00650	0.42196945
86	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41507497
87	Tuberculosis_Homo sapiens_hsa05152	0.40861659
88	Prion diseases_Homo sapiens_hsa05020	0.40291243
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.40014508
90	Notch signaling pathway_Homo sapiens_hsa04330	0.38061441
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.37686884
92	Olfactory transduction_Homo sapiens_hsa04740	0.36955654
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36462471
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36315535
95	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.36259201
96	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36171454
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.34466512
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.33965487
99	Insulin signaling pathway_Homo sapiens_hsa04910	0.33152312
100	Bile secretion_Homo sapiens_hsa04976	0.31245349

KRTAP4-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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