ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	9.10726127
2	adhesion of symbiont to host (GO:0044406)	8.70109806
3	peptide cross-linking (GO:0018149)	8.47465026
4	hair follicle morphogenesis (GO:0031069)	8.27769385
5	intermediate filament cytoskeleton organization (GO:0045104)	6.81090660
6	intermediate filament-based process (GO:0045103)	6.59427443
7	epidermis development (GO:0008544)	6.05245215
8	citrulline metabolic process (GO:0000052)	6.03274156
9	cell wall macromolecule catabolic process (GO:0016998)	5.82155494
10	cell wall macromolecule metabolic process (GO:0044036)	5.82155494
11	keratinocyte differentiation (GO:0030216)	5.76982773
12	establishment of skin barrier (GO:0061436)	5.55684737
13	hair cycle process (GO:0022405)	5.31260125
14	molting cycle process (GO:0022404)	5.31260125
15	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.26558263
16	peptidyl-arginine modification (GO:0018195)	5.05331464
17	hemidesmosome assembly (GO:0031581)	4.92981088
18	regulation of water loss via skin (GO:0033561)	4.92333656
19	skin morphogenesis (GO:0043589)	4.89835800
20	epidermal cell differentiation (GO:0009913)	4.48964202
21	molting cycle (GO:0042303)	35.1826165
22	hair cycle (GO:0042633)	35.1826165
23	tooth mineralization (GO:0034505)	3.73427616
24	keratinocyte development (GO:0003334)	3.72560422
25	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.33789472
26	negative regulation of keratinocyte proliferation (GO:0010839)	3.33762758
27	multicellular organismal water homeostasis (GO:0050891)	3.31686523
28	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.27414179
29	positive regulation of hair cycle (GO:0042635)	3.13947283
30	positive regulation of hair follicle development (GO:0051798)	3.13947283
31	hair follicle development (GO:0001942)	3.11198306
32	regulation of keratinocyte differentiation (GO:0045616)	3.09116997
33	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.03458048
34	regulation of hair follicle development (GO:0051797)	2.93947699
35	epithelium development (GO:0060429)	2.86748942
36	ectoderm development (GO:0007398)	2.86191781
37	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.76515305
38	gap junction assembly (GO:0016264)	2.74461031
39	negative regulation of protein localization to plasma membrane (GO:1903077)	2.72475548
40	water homeostasis (GO:0030104)	2.71027786
41	bone trabecula formation (GO:0060346)	2.67936530
42	positive regulation of epidermis development (GO:0045684)	2.67459217
43	atrioventricular valve morphogenesis (GO:0003181)	2.66498496
44	regulation of hair cycle (GO:0042634)	2.65071339
45	fatty acid elongation (GO:0030497)	2.61996085
46	positive regulation of meiotic cell cycle (GO:0051446)	2.56407701
47	ventricular cardiac muscle cell action potential (GO:0086005)	2.47270608
48	regulation of epidermal cell differentiation (GO:0045604)	2.42744408
49	regulation of epidermis development (GO:0045682)	2.37669834
50	negative regulation of cell fate specification (GO:0009996)	2.33928471
51	phosphatidylserine metabolic process (GO:0006658)	2.28371710
52	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.27319128
53	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.20348858
54	positive regulation of epidermal cell differentiation (GO:0045606)	2.18900825
55	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.18040300
56	lymph vessel development (GO:0001945)	2.16280588
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.12947261
58	skin development (GO:0043588)	2.12349573
59	positive regulation of monocyte chemotaxis (GO:0090026)	2.08319855
60	regulation of heart rate by cardiac conduction (GO:0086091)	2.07038864
61	wound healing, spreading of epidermal cells (GO:0035313)	2.06839363
62	aging (GO:0007568)	2.06447284
63	regulation of cardioblast differentiation (GO:0051890)	2.06062052
64	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.04165567
65	intermediate filament organization (GO:0045109)	12.3552905
66	keratinization (GO:0031424)	11.4574022
67	virion attachment to host cell (GO:0019062)	10.2992377
68	adhesion of symbiont to host cell (GO:0044650)	10.2992377
69	desmosome organization (GO:0002934)	10.1528691
70	epithelial cell-cell adhesion (GO:0090136)	1.99746532
71	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.96139808
72	cranial suture morphogenesis (GO:0060363)	1.95152200
73	cell communication involved in cardiac conduction (GO:0086065)	1.94935407
74	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.94582347
75	myotube differentiation (GO:0014902)	1.90238295
76	outflow tract septum morphogenesis (GO:0003148)	1.90042771
77	regulation of ruffle assembly (GO:1900027)	1.89263775
78	ephrin receptor signaling pathway (GO:0048013)	1.86713596
79	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.86012567
80	regulation of keratinocyte proliferation (GO:0010837)	1.85006859
81	negative regulation of epidermis development (GO:0045683)	1.84382013
82	cell-substrate junction assembly (GO:0007044)	1.80817182
83	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.80377147
84	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.80377147
85	non-canonical Wnt signaling pathway (GO:0035567)	1.71723508
86	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.70862612
87	coronary vasculature morphogenesis (GO:0060977)	1.69433847
88	alditol phosphate metabolic process (GO:0052646)	1.68590108
89	regulation of cardioblast proliferation (GO:0003264)	1.65474307
90	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.65474307
91	cardiac conduction (GO:0061337)	1.62292127
92	primary alcohol catabolic process (GO:0034310)	1.61831563
93	very long-chain fatty acid metabolic process (GO:0000038)	1.61342010
94	negative regulation of cell fate commitment (GO:0010454)	1.60512021
95	outer ear morphogenesis (GO:0042473)	1.59029546
96	cardiac muscle cell action potential involved in contraction (GO:0086002)	1.56543599
97	cellular modified amino acid biosynthetic process (GO:0042398)	1.56083939
98	regulation of transforming growth factor beta2 production (GO:0032909)	1.54685336
99	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.52874475
100	establishment of planar polarity (GO:0001736)	1.51405991

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.14420212
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.80361986
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.51614609
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.67657467
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.31947916
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.18744589
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.18462738
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.6354341
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.90031111
10	TAF2_19829295_ChIP-Seq_ESCs_Human	1.82930119
11	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75504449
12	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.72413091
13	EGR1_19032775_ChIP-ChIP_M12_Human	1.72205170
14	NANOG_20526341_ChIP-Seq_ESCs_Human	1.71719269
15	* E2F1_20622854_ChIP-Seq_HELA_Human	1.68228454
16	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.68213606
17	CTCF_27219007_Chip-Seq_Bcells_Human	1.62683197
18	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.56560457
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.54900252
20	ERG_20517297_ChIP-Seq_VCAP_Human	1.54544462
21	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.53802046
22	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.52054252
23	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.52054252
24	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.51869729
25	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.51865923
26	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.51211096
27	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49447614
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.49404091
29	TP63_22573176_ChIP-Seq_HFKS_Human	1.48845344
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.44937084
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.39117368
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.37944208
33	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.37088942
34	ATF3_27146783_Chip-Seq_COLON_Human	1.37010192
35	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36725073
36	* LXR_22292898_ChIP-Seq_THP-1_Human	1.35806646
37	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35800282
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33928216
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25641003
40	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.25467298
41	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.24641131
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24092828
43	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.23739592
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.22443805
45	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20755380
46	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.17817988
47	P68_20966046_ChIP-Seq_HELA_Human	1.16467142
48	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15721928
49	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.14497569
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14268953
51	CEBPB_22108803_ChIP-Seq_LS180_Human	1.13381424
52	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.12784478
53	SMC4_20622854_ChIP-Seq_HELA_Human	1.11268918
54	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.10188260
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.09823646
56	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.09779298
57	* PHF8_20622854_ChIP-Seq_HELA_Human	1.09344108
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.09314801
59	TP63_23658742_ChIP-Seq_EP156T_Human	1.09037751
60	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08538668
61	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.08283851
62	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.05288642
63	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.05250315
64	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04130651
65	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.03022206
66	SPI1_20517297_ChIP-Seq_HL60_Human	1.02130705
67	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00768585
68	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.00155189
69	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.99235507
70	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98404928
71	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.97300616
72	* RAC3_21632823_ChIP-Seq_H3396_Human	0.96113426
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.95776257
74	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95719909
75	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93926881
76	TP53_18474530_ChIP-ChIP_U2OS_Human	0.92943216
77	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.91577520
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91054533
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90793214
80	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88287991
81	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88118392
82	RXR_22108803_ChIP-Seq_LS180_Human	0.87240394
83	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86446500
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.85910000
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.85285004
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.84528718
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83651433
88	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.82908775
89	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.82554419
90	* SOX2_21211035_ChIP-Seq_LN229_Human	0.82472458
91	SOX2_20726797_ChIP-Seq_SW620_Human	0.82278787
92	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.80580444
93	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.78859343
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78172756
95	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.77980731
96	AR_21572438_ChIP-Seq_LNCaP_Human	0.75132504
97	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.74754171
98	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74050564
99	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.73979805
100	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.73832988

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.85663085
2	MP0002098_abnormal_vibrissa_morphology	7.16211484
3	MP0000647_abnormal_sebaceous_gland	6.43713732
4	MP0002796_impaired_skin_barrier	5.89152498
5	MP0005275_abnormal_skin_tensile	5.12189128
6	MP0010234_abnormal_vibrissa_follicle	5.08570275
7	MP0000383_abnormal_hair_follicle	4.53232080
8	MP0000377_abnormal_hair_follicle	4.09189827
9	MP0010678_abnormal_skin_adnexa	4.01931321
10	MP0003705_abnormal_hypodermis_morpholog	3.76898280
11	MP0005501_abnormal_skin_physiology	3.70878488
12	MP0000427_abnormal_hair_cycle	3.49329052
13	MP0002254_reproductive_system_inflammat	2.91002928
14	MP0001216_abnormal_epidermal_layer	2.66020545
15	MP0004381_abnormal_hair_follicle	2.61838303
16	MP0000367_abnormal_coat/_hair	2.36540504
17	MP0004947_skin_inflammation	2.31513269
18	MP0010771_integument_phenotype	2.28999648
19	MP0003453_abnormal_keratinocyte_physiol	2.20755718
20	MP0002060_abnormal_skin_morphology	2.13633415
21	MP0001243_abnormal_dermal_layer	2.11042008
22	MP0002234_abnormal_pharynx_morphology	2.10473815
23	MP0000467_abnormal_esophagus_morphology	1.85979008
24	MP0000762_abnormal_tongue_morphology	1.52054930
25	MP0009053_abnormal_anal_canal	1.48885099
26	MP0009931_abnormal_skin_appearance	1.47353811
27	MP0003566_abnormal_cell_adhesion	1.46369475
28	MP0005409_darkened_coat_color	1.45228472
29	MP0003941_abnormal_skin_development	1.19038903
30	MP0001191_abnormal_skin_condition	0.98956139
31	MP0004885_abnormal_endolymph	0.98482099
32	MP0004185_abnormal_adipocyte_glucose	0.86242788
33	MP0001851_eye_inflammation	0.85568092
34	MP0004264_abnormal_extraembryonic_tissu	0.85415988
35	MP0002095_abnormal_skin_pigmentation	0.78598930
36	MP0001849_ear_inflammation	0.70133147
37	MP0003315_abnormal_perineum_morphology	0.66355342
38	MP0008438_abnormal_cutaneous_collagen	0.63159474
39	MP0001340_abnormal_eyelid_morphology	0.62827579
40	MP0002877_abnormal_melanocyte_morpholog	0.61038687
41	MP0001661_extended_life_span	0.60784596
42	MP0001346_abnormal_lacrimal_gland	0.59314940
43	MP0005451_abnormal_body_composition	0.54980522
44	MP0000627_abnormal_mammary_gland	0.54735424
45	MP0002282_abnormal_trachea_morphology	0.53166009
46	MP0010030_abnormal_orbit_morphology	0.53077687
47	MP0003191_abnormal_cellular_cholesterol	0.51963225
48	MP0003755_abnormal_palate_morphology	0.50649223
49	MP0005023_abnormal_wound_healing	0.49358478
50	MP0000566_synostosis	0.48888005
51	MP0002970_abnormal_white_adipose	0.48031594
52	MP0001784_abnormal_fluid_regulation	0.45235603
53	MP0000678_abnormal_parathyroid_gland	0.43755246
54	MP0002249_abnormal_larynx_morphology	0.41332887
55	MP0005075_abnormal_melanosome_morpholog	0.40285309
56	MP0002111_abnormal_tail_morphology	0.38155550
57	MP0009840_abnormal_foam_cell	0.31595804
58	MP0004272_abnormal_basement_membrane	0.31548769
59	MP0010352_gastrointestinal_tract_polyps	0.30384550
60	MP0003385_abnormal_body_wall	0.28811987
61	MP0002177_abnormal_outer_ear	0.27447816
62	MP0003329_amyloid_beta_deposits	0.26729013
63	MP0003763_abnormal_thymus_physiology	0.25017346
64	MP0003950_abnormal_plasma_membrane	0.24770896
65	MP0000537_abnormal_urethra_morphology	0.24672300
66	MP0000465_gastrointestinal_hemorrhage	0.24488599
67	MP0002697_abnormal_eye_size	0.22245753
68	MP0005248_abnormal_Harderian_gland	0.21394467
69	MP0003300_gastrointestinal_ulcer	0.20513697
70	MP0004019_abnormal_vitamin_homeostasis	0.20223177
71	MP0004742_abnormal_vestibular_system	0.19386993
72	MP0001879_abnormal_lymphatic_vessel	0.19245826
73	MP0004858_abnormal_nervous_system	0.18354889
74	MP0000432_abnormal_head_morphology	0.15515182
75	MP0005666_abnormal_adipose_tissue	0.14291514
76	MP0008961_abnormal_basal_metabolism	0.14092160
77	MP0003448_altered_tumor_morphology	0.13786441
78	MP0005375_adipose_tissue_phenotype	0.13774384
79	MP0006054_spinal_hemorrhage	0.13563587
80	MP0000604_amyloidosis	0.13308373
81	MP0003935_abnormal_craniofacial_develop	0.13283446
82	MP0003011_delayed_dark_adaptation	0.13040114
83	MP0003075_altered_response_to	0.12064153
84	MP0003638_abnormal_response/metabolism_	0.12004432
85	MP0008569_lethality_at_weaning	0.11936349
86	MP0010368_abnormal_lymphatic_system	0.10956478
87	MP0002233_abnormal_nose_morphology	0.10547500
88	MP0005193_abnormal_anterior_eye	0.10191766
89	MP0003045_fibrosis	0.10018846
90	MP0005367_renal/urinary_system_phenotyp	0.09697467
91	MP0000516_abnormal_urinary_system	0.09697467
92	MP0000462_abnormal_digestive_system	0.07488425
93	MP0005076_abnormal_cell_differentiation	0.07388520
94	MP0002006_tumorigenesis	0.07274988
95	MP0000013_abnormal_adipose_tissue	0.07044134
96	MP0002090_abnormal_vision	0.06428924
97	MP0005452_abnormal_adipose_tissue	0.06120530
98	MP0000733_abnormal_muscle_development	0.06103524
99	MP0002166_altered_tumor_susceptibility	0.06023827
100	MP0006138_congestive_heart_failure	0.05836876

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.18347705
2	Nail dystrophy (HP:0008404)	7.29231427
3	Abnormality of nail color (HP:0100643)	6.68297859
4	Abnormal hair laboratory examination (HP:0003328)	5.80275892
5	Fragile nails (HP:0001808)	5.60249362
6	Fine hair (HP:0002213)	5.20948919
7	Alopecia of scalp (HP:0002293)	5.04726874
8	Palmoplantar hyperkeratosis (HP:0000972)	5.03759328
9	Onycholysis (HP:0001806)	4.98509147
10	Thick nail (HP:0001805)	4.90965805
11	Increased IgE level (HP:0003212)	4.88080557
12	Palmar hyperkeratosis (HP:0010765)	4.74458448
13	Plantar hyperkeratosis (HP:0007556)	4.56095534
14	Follicular hyperkeratosis (HP:0007502)	4.48940644
15	Right ventricular cardiomyopathy (HP:0011663)	4.30697665
16	Erythema (HP:0010783)	3.63438193
17	Oral leukoplakia (HP:0002745)	3.61011652
18	Sparse eyelashes (HP:0000653)	3.60249075
19	Milia (HP:0001056)	3.29274554
20	Amelogenesis imperfecta (HP:0000705)	3.10027048
21	Abnormality of the frontal sinuses (HP:0002687)	3.03885956
22	Erythroderma (HP:0001019)	3.01649464
23	Parakeratosis (HP:0001036)	2.88661018
24	Ridged nail (HP:0001807)	2.76787044
25	Curly hair (HP:0002212)	2.71894391
26	Intention tremor (HP:0002080)	2.69305141
27	Congenital, generalized hypertrichosis (HP:0004540)	2.62616518
28	Abnormal blistering of the skin (HP:0008066)	2.51879756
29	Natal tooth (HP:0000695)	2.47780754
30	Neck muscle weakness (HP:0000467)	2.44548446
31	Torticollis (HP:0000473)	2.39790240
32	Aplasia cutis congenita (HP:0001057)	2.38375118
33	Advanced eruption of teeth (HP:0006288)	2.38122289
34	Congenital ichthyosiform erythroderma (HP:0007431)	2.36351695
35	Dry hair (HP:0011359)	2.35052447
36	Hypohidrosis (HP:0000966)	2.14179648
37	Ventricular tachycardia (HP:0004756)	2.05522623
38	Corneal erosion (HP:0200020)	2.05396930
39	Palmoplantar keratoderma (HP:0000982)	2.04966232
40	Craniofacial dystonia (HP:0012179)	2.02674532
41	Hypotrichosis (HP:0001006)	14.6176818
42	Woolly hair (HP:0002224)	11.2220095
43	Slow-growing hair (HP:0002217)	11.0579340
44	Abnormality of hair growth rate (HP:0011363)	11.0579340
45	Brittle hair (HP:0002299)	10.1768553
46	Pruritus (HP:0000989)	1.96925126
47	Difficulty walking (HP:0002355)	1.93042606
48	Ventricular fibrillation (HP:0001663)	1.89590827
49	Focal dystonia (HP:0004373)	1.85418636
50	Abnormality of the pupil (HP:0000615)	1.82713983
51	Abnormality of the neuromuscular junction (HP:0003398)	1.73770831
52	Fatigable weakness (HP:0003473)	1.73770831
53	Abnormality of the dental root (HP:0006486)	1.71851888
54	Taurodontia (HP:0000679)	1.71851888
55	Abnormality of permanent molar morphology (HP:0011071)	1.71851888
56	Abnormality of the parietal bone (HP:0002696)	1.70695928
57	Abnormality of dental color (HP:0011073)	1.68758433
58	Abnormality of molar morphology (HP:0011070)	1.68129633
59	Abnormality of molar (HP:0011077)	1.68129633
60	Concave nail (HP:0001598)	1.67450359
61	Widely patent fontanelles and sutures (HP:0004492)	1.65692160
62	Absent eyelashes (HP:0000561)	1.64708395
63	Conjunctival hamartoma (HP:0100780)	1.62104151
64	Recurrent corneal erosions (HP:0000495)	1.59771731
65	Blepharitis (HP:0000498)	1.58353258
66	Unilateral renal agenesis (HP:0000122)	1.55830084
67	Abnormality of the dental pulp (HP:0006479)	1.49950334
68	Abnormality of the aortic arch (HP:0012303)	1.49862751
69	Sudden death (HP:0001699)	1.48012421
70	Hyporeflexia of lower limbs (HP:0002600)	1.46715170
71	Hypergammaglobulinemia (HP:0010702)	1.45616238
72	Anonychia (HP:0001798)	1.45370212
73	Abnormality of placental membranes (HP:0011409)	1.44919483
74	Amniotic constriction ring (HP:0009775)	1.44919483
75	Acanthosis nigricans (HP:0000956)	1.44142208
76	Carious teeth (HP:0000670)	1.43984441
77	Heterogeneous (HP:0001425)	1.41902472
78	Gangrene (HP:0100758)	1.37359244
79	Lip pit (HP:0100267)	1.36789608
80	Laryngomalacia (HP:0001601)	1.36561109
81	Keratoconjunctivitis sicca (HP:0001097)	1.34339633
82	Neonatal onset (HP:0003623)	1.32944568
83	Ectropion (HP:0000656)	1.32587108
84	Abnormality of the fingernails (HP:0001231)	1.30889571
85	Autoamputation (HP:0001218)	1.30574771
86	Craniofacial hyperostosis (HP:0004493)	1.27429442
87	Achilles tendon contracture (HP:0001771)	1.26475623
88	Distal lower limb muscle weakness (HP:0009053)	1.25567648
89	Hyperhidrosis (HP:0000975)	1.20627605
90	Abnormality of the Achilles tendon (HP:0005109)	1.19168974
91	Sparse scalp hair (HP:0002209)	1.18506714
92	Corneal dystrophy (HP:0001131)	1.18328452
93	Keratoconjunctivitis (HP:0001096)	1.18184146
94	Variable expressivity (HP:0003828)	1.17373765
95	Selective tooth agenesis (HP:0001592)	1.16909385
96	Widely spaced teeth (HP:0000687)	1.14185277
97	Abnormality of the gastric mucosa (HP:0004295)	1.13460339
98	Lack of skin elasticity (HP:0100679)	1.10775502
99	Bronchomalacia (HP:0002780)	1.09912596
100	Skin ulcer (HP:0200042)	1.09096086

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.34427510
2	EPHA2	4.30836765
3	MAP3K6	4.14123956
4	MAPKAPK3	4.04759785
5	ERN1	4.04111824
6	EPHB2	3.07585628
7	TAOK1	3.01605755
8	TRIB3	2.64510869
9	MAP3K3	2.64117709
10	MAP3K2	2.34847764
11	LATS1	2.22237037
12	MAP3K11	2.03193257
13	RPS6KB2	1.88783804
14	EPHB1	1.88618496
15	EEF2K	1.85085720
16	MAP2K6	1.69414211
17	TTN	1.62797432
18	PIK3CG	1.56333470
19	LATS2	1.55199652
20	FGFR4	1.49304224
21	BMX	1.32414516
22	BCR	1.30680458
23	MAP3K1	1.28651716
24	RIPK1	1.22257242
25	NME1	1.20197028
26	PKN2	1.18708979
27	KSR2	1.14690428
28	FGFR1	1.14400382
29	BLK	1.13122896
30	CDK6	1.11439312
31	MST1R	1.11396858
32	MAPKAPK2	1.09207712
33	FGFR3	1.09193207
34	PTK6	1.05389731
35	PDGFRA	1.05212153
36	MAP2K3	1.04596940
37	MAP3K9	1.04057798
38	FGFR2	1.03211766
39	MAP3K7	1.02348273
40	PTK2	0.94691327
41	RPS6KA4	0.92055858
42	LRRK2	0.89150585
43	SIK1	0.85517024
44	MAP2K4	0.85250302
45	STK38	0.81094122
46	EPHA3	0.79329390
47	PBK	0.71955867
48	MAP2K1	0.71896989
49	PIM2	0.70813108
50	DYRK1B	0.68732646
51	MAP3K10	0.67582362
52	PRKD1	0.66899634
53	PAK4	0.66153652
54	DDR2	0.65565008
55	PAK3	0.65292163
56	MET	0.63042035
57	TESK1	0.61794787
58	STK38L	0.61682406
59	CDK19	0.61048486
60	JAK1	0.60819732
61	TYK2	0.60760817
62	PRKCI	0.57403715
63	NTRK2	0.57309257
64	PRKCH	0.53885550
65	MAP3K5	0.53100256
66	RET	0.51487754
67	TYRO3	0.50454944
68	PAK2	0.49679545
69	PAK6	0.49477636
70	ALK	0.49091324
71	ERBB4	0.48202262
72	TRPM7	0.46166479
73	ERBB2	0.46078469
74	CLK1	0.44486244
75	TGFBR1	0.44319744
76	RPS6KA1	0.43558153
77	CSNK1E	0.41610780
78	MAPK12	0.41451514
79	GRK6	0.38931578
80	GSK3A	0.38510372
81	OBSCN	0.38247779
82	MARK2	0.35512518
83	FYN	0.34136166
84	JAK2	0.34069477
85	HCK	0.33405237
86	MAP3K8	0.31717914
87	SCYL2	0.30449755
88	MAP2K2	0.29510590
89	NEK1	0.28342439
90	CSNK1A1	0.26996344
91	STK11	0.26487481
92	MST4	0.25992115
93	TGFBR2	0.25760794
94	SRC	0.25261912
95	FES	0.23602833
96	MAPK8	0.23366926
97	PRKACG	0.22350306
98	PRKACA	0.20908767
99	CSNK1D	0.20192667
100	ILK	0.20002218

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.94941648
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.90201134
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.20834706
4	Fatty acid elongation_Homo sapiens_hsa00062	2.78172285
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.57331871
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.10406014
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.88893667
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.85237714
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.83990785
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.81980512
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.65041783
12	Axon guidance_Homo sapiens_hsa04360	1.57996110
13	Melanogenesis_Homo sapiens_hsa04916	1.51069753
14	Caffeine metabolism_Homo sapiens_hsa00232	1.49359712
15	Histidine metabolism_Homo sapiens_hsa00340	1.36281693
16	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30700973
17	Glioma_Homo sapiens_hsa05214	1.29409260
18	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.28796726
19	Thyroid cancer_Homo sapiens_hsa05216	1.27972498
20	Acute myeloid leukemia_Homo sapiens_hsa05221	1.27889384
21	Bladder cancer_Homo sapiens_hsa05219	1.27879354
22	Proteoglycans in cancer_Homo sapiens_hsa05205	1.22747312
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.18322913
24	GnRH signaling pathway_Homo sapiens_hsa04912	1.17168409
25	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.13343412
26	Pancreatic secretion_Homo sapiens_hsa04972	1.09592587
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07795585
28	Mineral absorption_Homo sapiens_hsa04978	1.05099454
29	Tight junction_Homo sapiens_hsa04530	1.04997583
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.04790856
31	Adherens junction_Homo sapiens_hsa04520	1.04588636
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.04415525
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.03121542
34	Long-term potentiation_Homo sapiens_hsa04720	1.02736545
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.95865201
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.94203072
37	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.94162195
38	ECM-receptor interaction_Homo sapiens_hsa04512	0.93037675
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.88967720
40	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.87144041
41	Estrogen signaling pathway_Homo sapiens_hsa04915	0.85058012
42	Pertussis_Homo sapiens_hsa05133	0.84443303
43	Ras signaling pathway_Homo sapiens_hsa04014	0.83624817
44	Long-term depression_Homo sapiens_hsa04730	0.83494638
45	Non-small cell lung cancer_Homo sapiens_hsa05223	0.82146730
46	Endometrial cancer_Homo sapiens_hsa05213	0.80636951
47	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79956417
48	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.78850510
49	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.75867938
50	Amoebiasis_Homo sapiens_hsa05146	0.72369671
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71610973
52	Wnt signaling pathway_Homo sapiens_hsa04310	0.70097072
53	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.68327453
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.67944271
55	Gastric acid secretion_Homo sapiens_hsa04971	0.65495619
56	Renin secretion_Homo sapiens_hsa04924	0.63446291
57	Phototransduction_Homo sapiens_hsa04744	0.61955206
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61645678
59	Hepatitis C_Homo sapiens_hsa05160	0.61149456
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60983722
61	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.60909154
62	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.60425783
63	Insulin resistance_Homo sapiens_hsa04931	0.58618367
64	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.56845810
65	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54614353
66	MicroRNAs in cancer_Homo sapiens_hsa05206	0.54235453
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.53951071
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.53371276
69	Salmonella infection_Homo sapiens_hsa05132	0.52113320
70	Gap junction_Homo sapiens_hsa04540	0.51822620
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51056151
72	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.51004332
73	Salivary secretion_Homo sapiens_hsa04970	0.49147130
74	ErbB signaling pathway_Homo sapiens_hsa04012	0.48373006
75	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.47849009
76	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.46839383
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.45865676
78	Focal adhesion_Homo sapiens_hsa04510	0.45485265
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44119180
80	Platelet activation_Homo sapiens_hsa04611	0.43008493
81	Butanoate metabolism_Homo sapiens_hsa00650	0.42274013
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41761434
83	Olfactory transduction_Homo sapiens_hsa04740	0.40980768
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40394645
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.39687740
86	Tuberculosis_Homo sapiens_hsa05152	0.39627443
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.39243226
88	Fatty acid degradation_Homo sapiens_hsa00071	0.38888215
89	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.38602846
90	Toxoplasmosis_Homo sapiens_hsa05145	0.38381474
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36604671
92	Prion diseases_Homo sapiens_hsa05020	0.36560982
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.36482765
94	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.36219961
95	Notch signaling pathway_Homo sapiens_hsa04330	0.35829510
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.34917231
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.34378442
98	Insulin signaling pathway_Homo sapiens_hsa04910	0.33063702
99	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.32922595
100	Circadian entrainment_Homo sapiens_hsa04713	0.32676244

KRTAP4-2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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