ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	9.22506744
2	adhesion of symbiont to host (GO:0044406)	8.68080648
3	hair follicle morphogenesis (GO:0031069)	8.33038300
4	peptide cross-linking (GO:0018149)	8.25695629
5	intermediate filament cytoskeleton organization (GO:0045104)	6.68951800
6	intermediate filament-based process (GO:0045103)	6.47749017
7	cell wall macromolecule catabolic process (GO:0016998)	6.23946665
8	cell wall macromolecule metabolic process (GO:0044036)	6.23946665
9	citrulline metabolic process (GO:0000052)	6.11125036
10	epidermis development (GO:0008544)	6.04202056
11	keratinocyte differentiation (GO:0030216)	5.64241620
12	molting cycle process (GO:0022404)	5.35547183
13	hair cycle process (GO:0022405)	5.35547183
14	establishment of skin barrier (GO:0061436)	5.17696082
15	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.16894811
16	peptidyl-arginine modification (GO:0018195)	5.11248301
17	skin morphogenesis (GO:0043589)	4.92260274
18	hemidesmosome assembly (GO:0031581)	4.80992197
19	regulation of water loss via skin (GO:0033561)	4.61176810
20	epidermal cell differentiation (GO:0009913)	4.40375689
21	molting cycle (GO:0042303)	35.3863536
22	hair cycle (GO:0042633)	35.3863536
23	tooth mineralization (GO:0034505)	3.87310304
24	keratinocyte development (GO:0003334)	3.72899688
25	negative regulation of keratinocyte proliferation (GO:0010839)	3.34693307
26	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.29423286
27	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.29160971
28	positive regulation of hair follicle development (GO:0051798)	3.26379739
29	positive regulation of hair cycle (GO:0042635)	3.26379739
30	hair follicle development (GO:0001942)	3.15465631
31	multicellular organismal water homeostasis (GO:0050891)	3.12578757
32	regulation of keratinocyte differentiation (GO:0045616)	3.11714005
33	regulation of hair follicle development (GO:0051797)	3.04679577
34	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.00428792
35	epithelium development (GO:0060429)	2.86016442
36	bone trabecula formation (GO:0060346)	2.83032607
37	ectoderm development (GO:0007398)	2.76501354
38	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.74314264
39	positive regulation of epidermis development (GO:0045684)	2.74035277
40	gap junction assembly (GO:0016264)	2.73738093
41	negative regulation of protein localization to plasma membrane (GO:1903077)	2.71589445
42	atrioventricular valve morphogenesis (GO:0003181)	2.68465311
43	regulation of hair cycle (GO:0042634)	2.66031175
44	fatty acid elongation (GO:0030497)	2.65575777
45	positive regulation of meiotic cell cycle (GO:0051446)	2.62423072
46	water homeostasis (GO:0030104)	2.56314357
47	regulation of epidermal cell differentiation (GO:0045604)	2.44187040
48	ventricular cardiac muscle cell action potential (GO:0086005)	2.43724554
49	regulation of epidermis development (GO:0045682)	2.40386663
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.35711887
51	negative regulation of cell fate specification (GO:0009996)	2.33797047
52	lymph vessel development (GO:0001945)	2.29056268
53	phosphatidylserine metabolic process (GO:0006658)	2.28842903
54	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.26197214
55	positive regulation of epidermal cell differentiation (GO:0045606)	2.23096857
56	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.19749133
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.16006493
58	wound healing, spreading of epidermal cells (GO:0035313)	2.13166520
59	skin development (GO:0043588)	2.11396450
60	regulation of cardioblast differentiation (GO:0051890)	2.09427203
61	aging (GO:0007568)	2.09246212
62	myotube differentiation (GO:0014902)	2.05273690
63	regulation of heart rate by cardiac conduction (GO:0086091)	2.02910232
64	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.02753162
65	epithelial cell-cell adhesion (GO:0090136)	2.01366383
66	cranial suture morphogenesis (GO:0060363)	2.00563203
67	intermediate filament organization (GO:0045109)	12.2592775
68	keratinization (GO:0031424)	10.8271572
69	adhesion of symbiont to host cell (GO:0044650)	10.2630580
70	virion attachment to host cell (GO:0019062)	10.2630580
71	desmosome organization (GO:0002934)	10.0047474
72	outflow tract septum morphogenesis (GO:0003148)	1.98822354
73	positive regulation of monocyte chemotaxis (GO:0090026)	1.97335541
74	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.95418240
75	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.94131254
76	negative regulation of epidermis development (GO:0045683)	1.90929837
77	cell communication involved in cardiac conduction (GO:0086065)	1.89382465
78	regulation of keratinocyte proliferation (GO:0010837)	1.87447484
79	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.86849475
80	regulation of ruffle assembly (GO:1900027)	1.85494212
81	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.78325029
82	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.78325029
83	ephrin receptor signaling pathway (GO:0048013)	1.77893623
84	coronary vasculature morphogenesis (GO:0060977)	1.77844018
85	cell-substrate junction assembly (GO:0007044)	1.77697285
86	regulation of cardioblast proliferation (GO:0003264)	1.74676632
87	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.74676632
88	non-canonical Wnt signaling pathway (GO:0035567)	1.72996967
89	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.71400642
90	alditol phosphate metabolic process (GO:0052646)	1.68931103
91	very long-chain fatty acid metabolic process (GO:0000038)	1.62817455
92	outer ear morphogenesis (GO:0042473)	1.62687087
93	cellular modified amino acid biosynthetic process (GO:0042398)	1.62237771
94	regulation of transforming growth factor beta2 production (GO:0032909)	1.61888507
95	primary alcohol catabolic process (GO:0034310)	1.61615850
96	negative regulation of cell fate commitment (GO:0010454)	1.60619143
97	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.60194032
98	cardiac conduction (GO:0061337)	1.58664042
99	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.55887523
100	cardiac right ventricle morphogenesis (GO:0003215)	1.55247653

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.78875079
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.80097183
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.48080186
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.63708122
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.33220103
6	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.23600024
7	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.18655926
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.5354937
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.97450079
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.84272069
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.82541712
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75097921
13	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.73792470
14	EGR1_19032775_ChIP-ChIP_M12_Human	1.73518440
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.71885302
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.71610171
17	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.67096711
18	CTCF_27219007_Chip-Seq_Bcells_Human	1.60855835
19	P53_21459846_ChIP-Seq_SAOS-2_Human	1.55668728
20	ERG_20517297_ChIP-Seq_VCAP_Human	1.55550356
21	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.52801747
22	LXR_22292898_ChIP-Seq_THP-1_Human	1.52569542
23	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.51322588
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.50398007
25	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.49991356
26	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49270739
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.48895930
28	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.46590118
29	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.46590118
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.46337885
31	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.41832430
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.38882706
33	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36431831
34	BCOR_27268052_Chip-Seq_Bcells_Human	1.36354139
35	ATF3_27146783_Chip-Seq_COLON_Human	1.36291462
36	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33416369
37	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32953109
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.26646735
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.25639146
40	PHF8_20622854_ChIP-Seq_HELA_Human	1.25436055
41	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.23368366
42	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.21202519
43	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.21021547
44	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20427838
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19710773
46	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.18845833
47	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18035646
48	P68_20966046_ChIP-Seq_HELA_Human	1.17358445
49	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.14942934
50	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14016122
51	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13452973
52	SMC4_20622854_ChIP-Seq_HELA_Human	1.12390679
53	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.12131253
54	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12106340
55	RAC3_21632823_ChIP-Seq_H3396_Human	1.11940150
56	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.10663258
57	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.09574018
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.08941861
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08006014
60	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06381205
61	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05714324
62	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.05582567
63	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.05091365
64	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04841151
65	TP63_23658742_ChIP-Seq_EP156T_Human	1.03724622
66	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.03466261
67	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.01970377
68	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.00902440
69	SOX2_21211035_ChIP-Seq_LN229_Human	0.99730220
70	SPI1_20517297_ChIP-Seq_HL60_Human	0.99003089
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97692358
72	KLF5_25053715_ChIP-Seq_YYC3_Human	0.96983332
73	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.95265201
74	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.95237335
75	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94146372
76	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92716288
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.92012130
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91659469
79	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88929497
80	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87968355
81	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.87225810
82	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.84778068
83	TP53_18474530_ChIP-ChIP_U2OS_Human	0.84708744
84	RXR_22108803_ChIP-Seq_LS180_Human	0.84487433
85	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.84237019
86	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.82240505
87	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.82117066
88	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82110438
89	SOX2_20726797_ChIP-Seq_SW620_Human	0.81475515
90	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.81457079
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.80062671
92	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.79552882
93	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77804418
94	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.75493992
95	AR_21572438_ChIP-Seq_LNCaP_Human	0.75402146
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.74831451
97	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.73540918
98	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.72601902
99	ZNF263_19887448_ChIP-Seq_K562_Human	0.72536493
100	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.72372908

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.85163459
2	MP0002098_abnormal_vibrissa_morphology	7.28166364
3	MP0000647_abnormal_sebaceous_gland	6.51860122
4	MP0002796_impaired_skin_barrier	5.80291510
5	MP0010234_abnormal_vibrissa_follicle	5.10669643
6	MP0005275_abnormal_skin_tensile	5.05835100
7	MP0000383_abnormal_hair_follicle	4.54184015
8	MP0000377_abnormal_hair_follicle	4.13834230
9	MP0010678_abnormal_skin_adnexa	4.02386283
10	MP0003705_abnormal_hypodermis_morpholog	3.74813102
11	MP0005501_abnormal_skin_physiology	3.64741691
12	MP0000427_abnormal_hair_cycle	3.52273606
13	MP0002254_reproductive_system_inflammat	2.91240461
14	MP0001216_abnormal_epidermal_layer	2.63444646
15	MP0004381_abnormal_hair_follicle	2.58132076
16	MP0000367_abnormal_coat/_hair	2.37817163
17	MP0004947_skin_inflammation	2.24991380
18	MP0010771_integument_phenotype	2.24859684
19	MP0003453_abnormal_keratinocyte_physiol	2.17436607
20	MP0001243_abnormal_dermal_layer	2.15446775
21	MP0002060_abnormal_skin_morphology	2.09382337
22	MP0002234_abnormal_pharynx_morphology	2.07881604
23	MP0000467_abnormal_esophagus_morphology	1.76883518
24	MP0009053_abnormal_anal_canal	1.50243473
25	MP0000762_abnormal_tongue_morphology	1.48533656
26	MP0009931_abnormal_skin_appearance	1.46466017
27	MP0003566_abnormal_cell_adhesion	1.45032377
28	MP0005409_darkened_coat_color	1.37026367
29	MP0003941_abnormal_skin_development	1.09120246
30	MP0001191_abnormal_skin_condition	0.96660299
31	MP0004885_abnormal_endolymph	0.95445708
32	MP0004264_abnormal_extraembryonic_tissu	0.91295411
33	MP0004185_abnormal_adipocyte_glucose	0.85674195
34	MP0001851_eye_inflammation	0.82022966
35	MP0002095_abnormal_skin_pigmentation	0.76554095
36	MP0003315_abnormal_perineum_morphology	0.70158100
37	MP0008438_abnormal_cutaneous_collagen	0.68283155
38	MP0001849_ear_inflammation	0.68152668
39	MP0001340_abnormal_eyelid_morphology	0.63913354
40	MP0001661_extended_life_span	0.63072876
41	MP0002877_abnormal_melanocyte_morpholog	0.62219557
42	MP0001346_abnormal_lacrimal_gland	0.61075618
43	MP0010030_abnormal_orbit_morphology	0.56056253
44	MP0000627_abnormal_mammary_gland	0.55430758
45	MP0005451_abnormal_body_composition	0.53924131
46	MP0002282_abnormal_trachea_morphology	0.53093422
47	MP0003191_abnormal_cellular_cholesterol	0.51418567
48	MP0003755_abnormal_palate_morphology	0.50873084
49	MP0000566_synostosis	0.50870328
50	MP0005023_abnormal_wound_healing	0.49055424
51	MP0002970_abnormal_white_adipose	0.47699413
52	MP0000678_abnormal_parathyroid_gland	0.45587590
53	MP0002249_abnormal_larynx_morphology	0.45573002
54	MP0001784_abnormal_fluid_regulation	0.43829767
55	MP0002111_abnormal_tail_morphology	0.39106135
56	MP0005075_abnormal_melanosome_morpholog	0.36859089
57	MP0009840_abnormal_foam_cell	0.35524397
58	MP0004272_abnormal_basement_membrane	0.32893538
59	MP0010352_gastrointestinal_tract_polyps	0.31845776
60	MP0003385_abnormal_body_wall	0.30202419
61	MP0000537_abnormal_urethra_morphology	0.26878069
62	MP0002177_abnormal_outer_ear	0.26831546
63	MP0003950_abnormal_plasma_membrane	0.25238881
64	MP0003329_amyloid_beta_deposits	0.25094363
65	MP0003763_abnormal_thymus_physiology	0.24899689
66	MP0003300_gastrointestinal_ulcer	0.24359692
67	MP0000465_gastrointestinal_hemorrhage	0.24352522
68	MP0002697_abnormal_eye_size	0.22891200
69	MP0004019_abnormal_vitamin_homeostasis	0.22289396
70	MP0005248_abnormal_Harderian_gland	0.20931504
71	MP0001879_abnormal_lymphatic_vessel	0.18232162
72	MP0006054_spinal_hemorrhage	0.16915828
73	MP0000432_abnormal_head_morphology	0.16797780
74	MP0004742_abnormal_vestibular_system	0.16341054
75	MP0003935_abnormal_craniofacial_develop	0.15627755
76	MP0003011_delayed_dark_adaptation	0.15251130
77	MP0004858_abnormal_nervous_system	0.14640910
78	MP0003448_altered_tumor_morphology	0.14514299
79	MP0005375_adipose_tissue_phenotype	0.14419479
80	MP0005666_abnormal_adipose_tissue	0.13729060
81	MP0003638_abnormal_response/metabolism_	0.13518228
82	MP0000516_abnormal_urinary_system	0.13465521
83	MP0005367_renal/urinary_system_phenotyp	0.13465521
84	MP0000604_amyloidosis	0.12385079
85	MP0005076_abnormal_cell_differentiation	0.11359739
86	MP0000733_abnormal_muscle_development	0.11320145
87	MP0003075_altered_response_to	0.10292076
88	MP0002233_abnormal_nose_morphology	0.10204646
89	MP0000462_abnormal_digestive_system	0.10057060
90	MP0003045_fibrosis	0.09219174
91	MP0005193_abnormal_anterior_eye	0.09206266
92	MP0010368_abnormal_lymphatic_system	0.09094653
93	MP0000751_myopathy	0.08497503
94	MP0002006_tumorigenesis	0.08337119
95	MP0006138_congestive_heart_failure	0.07382668
96	MP0000013_abnormal_adipose_tissue	0.06849229
97	MP0008569_lethality_at_weaning	0.06605746
98	MP0001958_emphysema	0.06219005
99	MP0002166_altered_tumor_susceptibility	0.06159911
100	MP0005165_increased_susceptibility_to	0.05516817

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.21280653
2	Nail dystrophy (HP:0008404)	7.32957898
3	Abnormality of nail color (HP:0100643)	6.45022315
4	Abnormal hair laboratory examination (HP:0003328)	5.82835835
5	Fragile nails (HP:0001808)	5.58730912
6	Fine hair (HP:0002213)	5.27695595
7	Alopecia of scalp (HP:0002293)	4.98852594
8	Onycholysis (HP:0001806)	4.97279832
9	Palmoplantar hyperkeratosis (HP:0000972)	4.81728757
10	Thick nail (HP:0001805)	4.68901700
11	Increased IgE level (HP:0003212)	4.67619252
12	Palmar hyperkeratosis (HP:0010765)	4.53258733
13	Follicular hyperkeratosis (HP:0007502)	4.42673775
14	Plantar hyperkeratosis (HP:0007556)	4.37766004
15	Right ventricular cardiomyopathy (HP:0011663)	4.25635736
16	Sparse eyelashes (HP:0000653)	3.56897438
17	Oral leukoplakia (HP:0002745)	3.51757290
18	Erythema (HP:0010783)	3.51651387
19	Milia (HP:0001056)	3.22815299
20	Amelogenesis imperfecta (HP:0000705)	3.12558767
21	Abnormality of the frontal sinuses (HP:0002687)	3.08660006
22	Parakeratosis (HP:0001036)	2.78832068
23	Erythroderma (HP:0001019)	2.77754981
24	Ridged nail (HP:0001807)	2.72361821
25	Curly hair (HP:0002212)	2.71158284
26	Intention tremor (HP:0002080)	2.65974693
27	Congenital, generalized hypertrichosis (HP:0004540)	2.64428398
28	Neck muscle weakness (HP:0000467)	2.47212923
29	Natal tooth (HP:0000695)	2.45556095
30	Torticollis (HP:0000473)	2.42232441
31	Aplasia cutis congenita (HP:0001057)	2.42123986
32	Abnormal blistering of the skin (HP:0008066)	2.41589781
33	Advanced eruption of teeth (HP:0006288)	2.37903241
34	Congenital ichthyosiform erythroderma (HP:0007431)	2.34113897
35	Dry hair (HP:0011359)	2.31110298
36	Hypohidrosis (HP:0000966)	2.06218233
37	Ventricular tachycardia (HP:0004756)	2.05370580
38	Craniofacial dystonia (HP:0012179)	2.04530990
39	Corneal erosion (HP:0200020)	2.00525928
40	Hypotrichosis (HP:0001006)	14.7259687
41	Woolly hair (HP:0002224)	11.2229586
42	Abnormality of hair growth rate (HP:0011363)	11.1430203
43	Slow-growing hair (HP:0002217)	11.1430203
44	Brittle hair (HP:0002299)	10.3262929
45	Palmoplantar keratoderma (HP:0000982)	1.97980855
46	Difficulty walking (HP:0002355)	1.92495631
47	Pruritus (HP:0000989)	1.90503903
48	Focal dystonia (HP:0004373)	1.86999176
49	Ventricular fibrillation (HP:0001663)	1.86234541
50	Abnormality of the pupil (HP:0000615)	1.84218219
51	Taurodontia (HP:0000679)	1.76885062
52	Abnormality of permanent molar morphology (HP:0011071)	1.76885062
53	Abnormality of the dental root (HP:0006486)	1.76885062
54	Abnormality of molar (HP:0011077)	1.73994790
55	Abnormality of molar morphology (HP:0011070)	1.73994790
56	Abnormality of the parietal bone (HP:0002696)	1.73669419
57	Abnormality of dental color (HP:0011073)	1.71804021
58	Concave nail (HP:0001598)	1.71443958
59	Abnormality of the neuromuscular junction (HP:0003398)	1.69500422
60	Fatigable weakness (HP:0003473)	1.69500422
61	Widely patent fontanelles and sutures (HP:0004492)	1.67214550
62	Unilateral renal agenesis (HP:0000122)	1.64608344
63	Absent eyelashes (HP:0000561)	1.62387023
64	Recurrent corneal erosions (HP:0000495)	1.59466945
65	Abnormality of the aortic arch (HP:0012303)	1.59214490
66	Blepharitis (HP:0000498)	1.54955239
67	Abnormality of the dental pulp (HP:0006479)	1.54407931
68	Sudden death (HP:0001699)	1.50604441
69	Hyporeflexia of lower limbs (HP:0002600)	1.49896613
70	Abnormality of placental membranes (HP:0011409)	1.48677237
71	Amniotic constriction ring (HP:0009775)	1.48677237
72	Acanthosis nigricans (HP:0000956)	1.45145746
73	Heterogeneous (HP:0001425)	1.42649456
74	Carious teeth (HP:0000670)	1.42131795
75	Anonychia (HP:0001798)	1.40909463
76	Hypergammaglobulinemia (HP:0010702)	1.37334693
77	Lip pit (HP:0100267)	1.34153488
78	Laryngomalacia (HP:0001601)	1.33770581
79	Keratoconjunctivitis sicca (HP:0001097)	1.33521536
80	Conjunctival hamartoma (HP:0100780)	1.32706073
81	Craniofacial hyperostosis (HP:0004493)	1.32599343
82	Neonatal onset (HP:0003623)	1.28677135
83	Autoamputation (HP:0001218)	1.28504713
84	Ectropion (HP:0000656)	1.28000631
85	Achilles tendon contracture (HP:0001771)	1.27718937
86	Abnormality of the fingernails (HP:0001231)	1.26853285
87	Distal lower limb muscle weakness (HP:0009053)	1.25483529
88	Gangrene (HP:0100758)	1.23393460
89	Selective tooth agenesis (HP:0001592)	1.20492192
90	Abnormality of the Achilles tendon (HP:0005109)	1.20268364
91	Sparse scalp hair (HP:0002209)	1.19832970
92	Variable expressivity (HP:0003828)	1.19577418
93	Widely spaced teeth (HP:0000687)	1.17625050
94	Keratoconjunctivitis (HP:0001096)	1.17046623
95	Round ear (HP:0100830)	1.14915252
96	Corneal dystrophy (HP:0001131)	1.13656819
97	Abnormality of the gastric mucosa (HP:0004295)	1.12370376
98	Hyperhidrosis (HP:0000975)	1.12270236
99	Type 1 muscle fiber predominance (HP:0003803)	1.11687478
100	Atrophic scars (HP:0001075)	1.09841700

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.34376170
2	EPHA2	4.29551391
3	MAP3K6	4.12114033
4	MAPKAPK3	3.92903810
5	ERN1	3.92191451
6	EPHB2	3.20400439
7	TAOK1	3.10974025
8	TRIB3	2.73364341
9	MAP3K3	2.64146439
10	LATS1	2.42174948
11	MAP3K2	2.28847395
12	PIK3CG	2.09040168
13	MAP3K11	2.03407181
14	EEF2K	1.99370078
15	RPS6KB2	1.95745101
16	EPHB1	1.79938498
17	TTN	1.79611986
18	LATS2	1.63943196
19	MAP2K6	1.51516216
20	BCR	1.39263117
21	FGFR4	1.38626350
22	RIPK1	1.29325440
23	MAP3K1	1.27107380
24	NME1	1.22269756
25	PKN2	1.21931165
26	BMX	1.21808903
27	KSR2	1.19242193
28	BLK	1.16553620
29	CDK6	1.15889149
30	MAPKAPK2	1.08106049
31	MAP2K3	1.06815545
32	PDGFRA	1.03892451
33	FGFR2	1.02180537
34	MAP3K7	1.00906306
35	PTK6	1.00695234
36	FGFR3	1.00469311
37	LRRK2	0.99880505
38	MST1R	0.98138907
39	FGFR1	0.95239589
40	MAP3K9	0.90324951
41	SIK1	0.88024842
42	PTK2	0.87852419
43	RPS6KA4	0.82342008
44	MAP2K4	0.78810052
45	PBK	0.77747938
46	OBSCN	0.77624040
47	STK38	0.77530022
48	MAP2K1	0.74209912
49	PAK4	0.73918636
50	CDK19	0.70217551
51	STK38L	0.70066869
52	MAP3K10	0.68921056
53	PRKD1	0.68332742
54	PAK3	0.68142771
55	DYRK1B	0.66905463
56	PIM2	0.64492637
57	TESK1	0.62646531
58	MET	0.62033204
59	DDR2	0.58955433
60	TYK2	0.58447028
61	ERBB4	0.58283497
62	PAK6	0.57124468
63	JAK1	0.55045093
64	PRKCI	0.54904270
65	PAK2	0.54335482
66	TYRO3	0.53254940
67	EPHA3	0.52845707
68	PRKCH	0.52735385
69	TRPM7	0.52233113
70	RET	0.51897715
71	TGFBR1	0.48321129
72	NTRK2	0.48054519
73	MAP3K5	0.48009006
74	ERBB2	0.46496657
75	ALK	0.45729946
76	RPS6KA1	0.45321862
77	MAPK12	0.42735560
78	CLK1	0.40854312
79	CSNK1E	0.40073995
80	GSK3A	0.39011253
81	NEK1	0.38783625
82	MAP3K8	0.36748312
83	GRK6	0.36021247
84	JAK2	0.34984676
85	MST4	0.34095944
86	MAP2K2	0.33483457
87	FYN	0.32423057
88	TGFBR2	0.25482620
89	CSNK1A1	0.25352704
90	SRC	0.24992899
91	STK11	0.24748279
92	MAP4K1	0.24459159
93	HCK	0.23657889
94	PHKG1	0.23331195
95	PHKG2	0.23331195
96	ILK	0.23183718
97	LIMK1	0.22489697
98	FES	0.22344180
99	NTRK1	0.21661396
100	ABL2	0.21602751

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	5.00444263
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.94896739
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.29296199
4	Fatty acid elongation_Homo sapiens_hsa00062	2.94272469
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.62398599
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.22453872
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.90450252
8	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.86499180
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.82929131
10	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.81296968
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.62017355
12	Melanogenesis_Homo sapiens_hsa04916	1.56833703
13	Axon guidance_Homo sapiens_hsa04360	1.52378631
14	Caffeine metabolism_Homo sapiens_hsa00232	1.50512486
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.39635052
16	Histidine metabolism_Homo sapiens_hsa00340	1.36330472
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30169987
18	Bladder cancer_Homo sapiens_hsa05219	1.28605981
19	Glioma_Homo sapiens_hsa05214	1.28084021
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.25340038
21	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.25247016
22	Thyroid cancer_Homo sapiens_hsa05216	1.24997037
23	Proteoglycans in cancer_Homo sapiens_hsa05205	1.24373983
24	Acute myeloid leukemia_Homo sapiens_hsa05221	1.22565178
25	Hippo signaling pathway_Homo sapiens_hsa04390	1.21908730
26	GnRH signaling pathway_Homo sapiens_hsa04912	1.15972637
27	Pancreatic secretion_Homo sapiens_hsa04972	1.13975848
28	Tight junction_Homo sapiens_hsa04530	1.11662040
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08818251
30	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.08071436
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.07056984
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.06686646
33	Mineral absorption_Homo sapiens_hsa04978	1.05338200
34	Adherens junction_Homo sapiens_hsa04520	0.99099990
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.96671780
36	ECM-receptor interaction_Homo sapiens_hsa04512	0.96215181
37	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.95928945
38	Long-term potentiation_Homo sapiens_hsa04720	0.92870046
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.88968986
40	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.87848669
41	Endometrial cancer_Homo sapiens_hsa05213	0.83909155
42	beta-Alanine metabolism_Homo sapiens_hsa00410	0.83259117
43	Non-small cell lung cancer_Homo sapiens_hsa05223	0.82305587
44	Pertussis_Homo sapiens_hsa05133	0.80615486
45	Ras signaling pathway_Homo sapiens_hsa04014	0.80203071
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.79815495
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.78146365
48	Amoebiasis_Homo sapiens_hsa05146	0.76260846
49	Long-term depression_Homo sapiens_hsa04730	0.75788428
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.74469410
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.74260465
52	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73535765
53	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68644996
54	Gastric acid secretion_Homo sapiens_hsa04971	0.68206519
55	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.68000926
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.65442049
57	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62195656
58	Insulin resistance_Homo sapiens_hsa04931	0.61625284
59	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.61544194
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60220630
61	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.58912923
62	Renin secretion_Homo sapiens_hsa04924	0.58898480
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.58603469
64	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.56811905
65	Hepatitis C_Homo sapiens_hsa05160	0.55172237
66	Gap junction_Homo sapiens_hsa04540	0.52377503
67	Phototransduction_Homo sapiens_hsa04744	0.52015845
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.51773310
69	Salivary secretion_Homo sapiens_hsa04970	0.49631996
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49372906
71	Fatty acid degradation_Homo sapiens_hsa00071	0.48747179
72	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.48485712
73	Salmonella infection_Homo sapiens_hsa05132	0.48335455
74	Focal adhesion_Homo sapiens_hsa04510	0.47903024
75	Butanoate metabolism_Homo sapiens_hsa00650	0.46761006
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.46462665
77	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.45177135
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45035445
79	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44791666
80	Renal cell carcinoma_Homo sapiens_hsa05211	0.44695162
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.44603884
82	Platelet activation_Homo sapiens_hsa04611	0.44107241
83	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.43601670
84	Notch signaling pathway_Homo sapiens_hsa04330	0.43475669
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43437778
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42619371
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41118206
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40482342
89	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40014747
90	Prion diseases_Homo sapiens_hsa05020	0.38041072
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.35770386
92	Toxoplasmosis_Homo sapiens_hsa05145	0.35766673
93	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.35657688
94	Prolactin signaling pathway_Homo sapiens_hsa04917	0.35294926
95	Tuberculosis_Homo sapiens_hsa05152	0.34497211
96	Olfactory transduction_Homo sapiens_hsa04740	0.33732881
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.33272954
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31981190
99	Bile secretion_Homo sapiens_hsa04976	0.31266602
100	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.30257015

KRTAP4-6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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