KRTAP4-7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.50355528
2adhesion of symbiont to host (GO:0044406)9.07287136
3peptide cross-linking (GO:0018149)8.77272996
4hair follicle morphogenesis (GO:0031069)8.63899761
5intermediate filament cytoskeleton organization (GO:0045104)7.00883013
6intermediate filament-based process (GO:0045103)6.78636570
7citrulline metabolic process (GO:0000052)6.30231814
8epidermis development (GO:0008544)6.28549283
9cell wall macromolecule metabolic process (GO:0044036)6.25917926
10cell wall macromolecule catabolic process (GO:0016998)6.25917926
11linoleic acid metabolic process (GO:0043651)6.22351060
12keratinocyte differentiation (GO:0030216)5.98897039
13establishment of skin barrier (GO:0061436)5.74522198
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.59642936
15molting cycle process (GO:0022404)5.55377223
16hair cycle process (GO:0022405)5.55377223
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.46659928
18fatty-acyl-CoA biosynthetic process (GO:0046949)5.40620949
19peptidyl-arginine modification (GO:0018195)5.26278469
20skin morphogenesis (GO:0043589)5.12394788
21regulation of water loss via skin (GO:0033561)5.09952597
22hemidesmosome assembly (GO:0031581)5.05330724
23retinol metabolic process (GO:0042572)4.82440763
24epidermal cell differentiation (GO:0009913)4.66757100
25acyl-CoA biosynthetic process (GO:0071616)4.41773827
26thioester biosynthetic process (GO:0035384)4.41773827
27fatty-acyl-CoA metabolic process (GO:0035337)4.40740801
28keratinocyte proliferation (GO:0043616)4.05108227
29* hair cycle (GO:0042633)33.5501485
30* molting cycle (GO:0042303)33.5501485
31tooth mineralization (GO:0034505)3.94837667
32keratinocyte development (GO:0003334)3.88592934
33positive regulation of keratinocyte differentiation (GO:0045618)3.66453688
34alpha-linolenic acid metabolic process (GO:0036109)3.59238268
35primary alcohol metabolic process (GO:0034308)3.51460684
36negative regulation of keratinocyte proliferation (GO:0010839)3.47619466
37multicellular organismal water homeostasis (GO:0050891)3.44150273
38phosphatidylinositol acyl-chain remodeling (GO:0036149)3.43267295
39negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.41125159
40positive regulation of chemokine secretion (GO:0090197)3.33366367
41defense response to fungus (GO:0050832)3.32550425
42long-chain fatty acid biosynthetic process (GO:0042759)3.32306723
43hair follicle development (GO:0001942)3.26974046
44killing of cells of other organism (GO:0031640)3.26373732
45disruption of cells of other organism (GO:0044364)3.26373732
46positive regulation of hair cycle (GO:0042635)3.26008156
47positive regulation of hair follicle development (GO:0051798)3.26008156
48regulation of keratinocyte differentiation (GO:0045616)3.23067751
49triglyceride biosynthetic process (GO:0019432)3.18661462
50regulation of sequestering of triglyceride (GO:0010889)3.18079344
51phosphatidylserine acyl-chain remodeling (GO:0036150)3.14629011
52regulation of hair follicle development (GO:0051797)3.07089213
53neutral lipid biosynthetic process (GO:0046460)3.00683731
54acylglycerol biosynthetic process (GO:0046463)3.00683731
55regulation of chemokine secretion (GO:0090196)2.99981733
56epithelium development (GO:0060429)2.97380092
57lipoxygenase pathway (GO:0019372)2.96645905
58ectoderm development (GO:0007398)2.91603075
59negative regulation of execution phase of apoptosis (GO:1900118)2.91571378
60phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.87658311
61gap junction assembly (GO:0016264)2.85538632
62negative regulation of protein localization to plasma membrane (GO:1903077)2.82422273
63water homeostasis (GO:0030104)2.81565386
64bone trabecula formation (GO:0060346)2.79195045
65atrioventricular valve morphogenesis (GO:0003181)2.79017032
66positive regulation of epidermis development (GO:0045684)2.78985936
67fatty acid elongation (GO:0030497)2.73909410
68regulation of hair cycle (GO:0042634)2.72727320
69positive regulation of meiotic cell cycle (GO:0051446)2.67971642
70acyl-CoA metabolic process (GO:0006637)2.62832715
71thioester metabolic process (GO:0035383)2.62832715
72one-carbon compound transport (GO:0019755)2.58591169
73carnitine metabolic process (GO:0009437)2.55504905
74ventricular cardiac muscle cell action potential (GO:0086005)2.54701278
75regulation of epidermal cell differentiation (GO:0045604)2.53547272
76regulation of defense response to virus by host (GO:0050691)2.52378220
77regulation of epidermis development (GO:0045682)2.48013485
78regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44608579
79negative regulation of cell fate specification (GO:0009996)2.43396352
80epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.40315830
81phosphatidylserine metabolic process (GO:0006658)2.38545329
82response to phenylpropanoid (GO:0080184)2.37509552
83lymph vessel development (GO:0001945)2.32120185
84positive regulation of epidermal cell differentiation (GO:0045606)2.29240726
85phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.28909906
86regulation of mesenchymal cell apoptotic process (GO:2001053)2.28730163
87cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23731485
88fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.21661765
89skin development (GO:0043588)2.21049636
90wound healing, spreading of epidermal cells (GO:0035313)2.17302248
91regulation of cardioblast differentiation (GO:0051890)2.16472662
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.13124252
93regulation of heart rate by cardiac conduction (GO:0086091)2.13070979
94positive regulation of monocyte chemotaxis (GO:0090026)2.12513878
95epithelial cell-cell adhesion (GO:0090136)2.10767173
96response to fungus (GO:0009620)2.10596255
97fatty acid biosynthetic process (GO:0006633)2.10199457
98cranial suture morphogenesis (GO:0060363)2.06842570
99myotube differentiation (GO:0014902)2.05988361
100detection of bacterium (GO:0016045)2.05345808
101regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.03691327
102outflow tract septum morphogenesis (GO:0003148)2.02438879
103phosphatidylcholine acyl-chain remodeling (GO:0036151)2.02161934
104cell communication involved in cardiac conduction (GO:0086065)2.01736028
105intermediate filament organization (GO:0045109)12.7970840
106keratinization (GO:0031424)11.7792788
107virion attachment to host cell (GO:0019062)10.7285850
108adhesion of symbiont to host cell (GO:0044650)10.7285850
109desmosome organization (GO:0002934)10.5309227
110regulation of ruffle assembly (GO:1900027)1.97309072
111unsaturated fatty acid biosynthetic process (GO:0006636)1.97014132
112ethanol metabolic process (GO:0006067)1.96269236
113planar cell polarity pathway involved in neural tube closure (GO:0090179)1.95812665
114negative regulation of epidermis development (GO:0045683)1.94067035
115regulation of keratinocyte proliferation (GO:0010837)1.93612723
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.88332102
117antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.88332102
118regulation of phospholipase A2 activity (GO:0032429)1.86686572
119ephrin receptor signaling pathway (GO:0048013)1.85800535
120cell-substrate junction assembly (GO:0007044)1.85688231
121phosphatidic acid biosynthetic process (GO:0006654)1.81702994
122phosphatidic acid metabolic process (GO:0046473)1.81702994
123coronary vasculature morphogenesis (GO:0060977)1.81602294
124detection of other organism (GO:0098543)1.81100837
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.80353410
126non-canonical Wnt signaling pathway (GO:0035567)1.80192939
127* aging (GO:0007568)1.79785613
128regulation of secondary heart field cardioblast proliferation (GO:0003266)1.77551041
129regulation of cardioblast proliferation (GO:0003264)1.77551041
130alditol phosphate metabolic process (GO:0052646)1.76493369
131amino-acid betaine metabolic process (GO:0006577)1.74433167
132very long-chain fatty acid metabolic process (GO:0000038)1.71134376
133positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.70920553
134primary alcohol catabolic process (GO:0034310)1.70678690
135negative regulation of cell fate commitment (GO:0010454)1.67541015
136cardiac conduction (GO:0061337)1.66681663
137cellular modified amino acid biosynthetic process (GO:0042398)1.64423454
138regulation of transforming growth factor beta2 production (GO:0032909)1.64107472
139cell killing (GO:0001906)1.63935776
140lipid storage (GO:0019915)1.62744339
141outer ear morphogenesis (GO:0042473)1.62739617
142cardiac muscle cell action potential involved in contraction (GO:0086002)1.61640059
143long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.61638797
144retinoid metabolic process (GO:0001523)1.60566184
145establishment of planar polarity (GO:0001736)1.59985910
146diterpenoid metabolic process (GO:0016101)1.58335316
147lateral sprouting from an epithelium (GO:0060601)1.57850963
148triglyceride metabolic process (GO:0006641)1.56202140
149epithelial cell differentiation involved in prostate gland development (GO:0060742)1.54082158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.37610237
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.81383451
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.53490836
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.66239375
5CTCF_20526341_ChIP-Seq_ESCs_Human2.34217033
6NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.19991337
7BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.19738245
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.6139189
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.94396517
10E2F1_20622854_ChIP-Seq_HELA_Human1.85804962
11TAF2_19829295_ChIP-Seq_ESCs_Human1.82851163
12EGR1_19032775_ChIP-ChIP_M12_Human1.75036847
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74165982
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.72916376
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.72440276
16NANOG_20526341_ChIP-Seq_ESCs_Human1.71563609
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68164934
18CTCF_27219007_Chip-Seq_Bcells_Human1.60977507
19ERG_20517297_ChIP-Seq_VCAP_Human1.57754492
20P53_21459846_ChIP-Seq_SAOS-2_Human1.55440109
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.53227489
22LXR_22292898_ChIP-Seq_THP-1_Human1.52481070
23MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.51995547
24RACK7_27058665_Chip-Seq_MCF-7_Human1.51399200
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.51015433
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50932179
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50932179
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49733788
29TP63_22573176_ChIP-Seq_HFKS_Human1.49390209
30BCL6_27268052_Chip-Seq_Bcells_Human1.46897965
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46031720
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.41980561
33BCOR_27268052_Chip-Seq_Bcells_Human1.38681624
34ATF3_27146783_Chip-Seq_COLON_Human1.38604905
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37267440
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.36770517
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36449728
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31858518
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.27873843
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27395337
41PHF8_20622854_ChIP-Seq_HELA_Human1.26032905
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23191469
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22580338
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.22580338
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.22516080
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19616531
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19200288
48AHR_22903824_ChIP-Seq_MCF-7_Human1.19197975
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18313529
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17909372
51P68_20966046_ChIP-Seq_HELA_Human1.17626945
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16327623
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.15041370
54CEBPB_22108803_ChIP-Seq_LS180_Human1.14495707
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14327690
56E2F1_17053090_ChIP-ChIP_MCF-7_Human1.12768405
57RAC3_21632823_ChIP-Seq_H3396_Human1.12252546
58SMC4_20622854_ChIP-Seq_HELA_Human1.11891437
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.10533851
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07873868
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07750423
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07457463
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07404798
64JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06547892
65TP63_23658742_ChIP-Seq_EP156T_Human1.06534962
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.06453780
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.06367543
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01337949
69SPI1_20517297_ChIP-Seq_HL60_Human1.01273055
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.00966011
71SOX2_21211035_ChIP-Seq_LN229_Human0.99851746
72KLF5_25053715_ChIP-Seq_YYC3_Human0.98364403
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97936022
74* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96536044
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95012994
76ERG_21242973_ChIP-ChIP_JURKAT_Human0.94867939
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94538954
78HTT_18923047_ChIP-ChIP_STHdh_Human0.92932085
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.92442867
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91907802
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90803866
82* GATA4_25053715_ChIP-Seq_YYC3_Human0.90220251
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88836237
84TP53_18474530_ChIP-ChIP_U2OS_Human0.88358122
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.88184848
86* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87735791
87RING1B_27294783_Chip-Seq_ESCs_Mouse0.87635469
88RUNX1_27514584_Chip-Seq_MCF-7_Human0.87463661
89RXR_22108803_ChIP-Seq_LS180_Human0.86254663
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86185173
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86144555
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85049029
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83939610
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83939610
95SOX2_20726797_ChIP-Seq_SW620_Human0.83351233
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83181277
97* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81473965
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.81190791
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79984965
100ZNF263_19887448_ChIP-Seq_K562_Human0.79980597
101CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.79511879
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79368379
103EZH2_27294783_Chip-Seq_ESCs_Mouse0.78694321
104EZH2_27304074_Chip-Seq_ESCs_Mouse0.77503137
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.76095879
106P300_27268052_Chip-Seq_Bcells_Human0.75352715
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75328483
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74741016
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.74495888
110AR_21572438_ChIP-Seq_LNCaP_Human0.74398116
111OCT4_20526341_ChIP-Seq_ESCs_Human0.74183647
112FOXH1_21741376_ChIP-Seq_EPCs_Human0.74007135
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73702065
114PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73673534
115PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.73305281
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73262071
117CBP_20019798_ChIP-Seq_JUKART_Human0.73262071
118CBX2_27304074_Chip-Seq_ESCs_Mouse0.72968317
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72697443
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70523841
121KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69716097
122MYC_19829295_ChIP-Seq_ESCs_Human0.69508500
123SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68515875
124ERA_21632823_ChIP-Seq_H3396_Human0.68433036
125PHF8_20622853_ChIP-Seq_HELA_Human0.66849991
126STAT1_20625510_ChIP-Seq_HELA_Human0.66583954
127KAP1_27257070_Chip-Seq_ESCs_Mouse0.66505439
128NCOR_22424771_ChIP-Seq_293T_Human0.66400442
129HNFA_21074721_ChIP-Seq_CACO-2_Human0.65453791
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61943625
131SMAD4_21741376_ChIP-Seq_ESCs_Human0.61338513
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61092901
133RBPJ_21746931_ChIP-Seq_IB4_Human0.60212135
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.60046626
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.59751246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.78690340
2MP0002098_abnormal_vibrissa_morphology7.20006843
3MP0000647_abnormal_sebaceous_gland6.47024253
4MP0002796_impaired_skin_barrier5.87494542
5MP0005275_abnormal_skin_tensile5.12327693
6MP0010234_abnormal_vibrissa_follicle5.09502587
7MP0000383_abnormal_hair_follicle4.55074664
8MP0000377_abnormal_hair_follicle4.10892073
9MP0010678_abnormal_skin_adnexa4.03499029
10MP0003705_abnormal_hypodermis_morpholog3.77791484
11MP0005501_abnormal_skin_physiology3.69124730
12MP0009379_abnormal_foot_pigmentation3.66046768
13MP0000427_abnormal_hair_cycle3.50823331
14MP0002254_reproductive_system_inflammat2.93174225
15MP0001216_abnormal_epidermal_layer2.65542628
16MP0004381_abnormal_hair_follicle2.57544027
17MP0000367_abnormal_coat/_hair2.36944128
18MP0005377_hearing/vestibular/ear_phenot2.33402804
19MP0003878_abnormal_ear_physiology2.33402804
20MP0004947_skin_inflammation2.31048595
21MP0010771_integument_phenotype2.27653574
22MP0003453_abnormal_keratinocyte_physiol2.18423570
23MP0001243_abnormal_dermal_layer2.14041133
24MP0002060_abnormal_skin_morphology2.11480996
25MP0002234_abnormal_pharynx_morphology2.06824722
26MP0000467_abnormal_esophagus_morphology1.78680068
27MP0009053_abnormal_anal_canal1.51096544
28MP0000762_abnormal_tongue_morphology1.48510918
29MP0009931_abnormal_skin_appearance1.48278574
30MP0003566_abnormal_cell_adhesion1.46267010
31MP0005409_darkened_coat_color1.36571049
32MP0003941_abnormal_skin_development1.12338314
33MP0001188_hyperpigmentation1.10917795
34MP0006035_abnormal_mitochondrial_morpho1.00710227
35MP0001191_abnormal_skin_condition0.98115721
36MP0004885_abnormal_endolymph0.94822434
37MP0005647_abnormal_sex_gland0.94627367
38MP0004185_abnormal_adipocyte_glucose0.86907647
39MP0004264_abnormal_extraembryonic_tissu0.84105735
40MP0001851_eye_inflammation0.84042899
41MP0002095_abnormal_skin_pigmentation0.79851806
42MP0005174_abnormal_tail_pigmentation0.79369957
43MP0001849_ear_inflammation0.67909621
44MP0003315_abnormal_perineum_morphology0.67472213
45MP0000015_abnormal_ear_pigmentation0.66774330
46MP0001661_extended_life_span0.65748606
47MP0008438_abnormal_cutaneous_collagen0.64758641
48MP0001340_abnormal_eyelid_morphology0.64026192
49MP0002877_abnormal_melanocyte_morpholog0.62326402
50MP0001346_abnormal_lacrimal_gland0.61816278
51MP0001485_abnormal_pinna_reflex0.60499731
52MP0010030_abnormal_orbit_morphology0.56682343
53MP0003191_abnormal_cellular_cholesterol0.55227031
54MP0000627_abnormal_mammary_gland0.54892154
55MP0000566_synostosis0.52896271
56MP0002282_abnormal_trachea_morphology0.52077166
57MP0005451_abnormal_body_composition0.51737964
58MP0003755_abnormal_palate_morphology0.49197378
59MP0005023_abnormal_wound_healing0.49110847
60MP0002970_abnormal_white_adipose0.47872494
61MP0001784_abnormal_fluid_regulation0.45138480
62MP0002249_abnormal_larynx_morphology0.41411350
63MP0000678_abnormal_parathyroid_gland0.40405708
64MP0003646_muscle_fatigue0.39655115
65MP0002111_abnormal_tail_morphology0.38587583
66MP0005075_abnormal_melanosome_morpholog0.37646120
67MP0004782_abnormal_surfactant_physiolog0.36944034
68MP0009840_abnormal_foam_cell0.35593726
69MP0005535_abnormal_body_temperature0.35565961
70MP0010352_gastrointestinal_tract_polyps0.33119006
71MP0004272_abnormal_basement_membrane0.32939402
72MP0005503_abnormal_tendon_morphology0.31551153
73MP0003385_abnormal_body_wall0.29543067
74MP0000537_abnormal_urethra_morphology0.28267729
75MP0003329_amyloid_beta_deposits0.27121817
76MP0002177_abnormal_outer_ear0.26556717
77MP0000465_gastrointestinal_hemorrhage0.26129935
78MP0002163_abnormal_gland_morphology0.25870225
79MP0003950_abnormal_plasma_membrane0.25769876
80MP0003763_abnormal_thymus_physiology0.25641900
81MP0001984_abnormal_olfaction0.25418188
82MP0005452_abnormal_adipose_tissue0.24204935
83MP0002697_abnormal_eye_size0.23881965
84MP0005671_abnormal_response_to0.23870804
85MP0005248_abnormal_Harderian_gland0.22667282
86MP0003300_gastrointestinal_ulcer0.22648833
87MP0001919_abnormal_reproductive_system0.20821734
88MP0004019_abnormal_vitamin_homeostasis0.20754951
89MP0001879_abnormal_lymphatic_vessel0.18882951
90MP0006054_spinal_hemorrhage0.18189291
91MP0004742_abnormal_vestibular_system0.18015597
92MP0000432_abnormal_head_morphology0.16320104
93MP0001905_abnormal_dopamine_level0.15665475
94MP0004858_abnormal_nervous_system0.15404521
95MP0003448_altered_tumor_morphology0.15141608
96MP0005666_abnormal_adipose_tissue0.14848732
97MP0005646_abnormal_pituitary_gland0.14573788
98MP0003011_delayed_dark_adaptation0.14546348
99MP0000604_amyloidosis0.14401096
100MP0005375_adipose_tissue_phenotype0.14318092
101MP0003935_abnormal_craniofacial_develop0.14292998
102MP0005379_endocrine/exocrine_gland_phen0.13886867
103MP0003638_abnormal_response/metabolism_0.13343165
104MP0002009_preneoplasia0.13267539
105MP0002971_abnormal_brown_adipose0.12625158
106MP0004043_abnormal_pH_regulation0.11974100
107MP0000516_abnormal_urinary_system0.11714912
108MP0005367_renal/urinary_system_phenotyp0.11714912
109MP0003075_altered_response_to0.11678563
110MP0005076_abnormal_cell_differentiation0.11261851
111MP0002233_abnormal_nose_morphology0.10082481
112MP0005193_abnormal_anterior_eye0.09759180
113MP0000358_abnormal_cell_content/0.09751329
114MP0010368_abnormal_lymphatic_system0.09097425
115MP0002006_tumorigenesis0.08990182
116MP0003045_fibrosis0.08522958
117MP0000733_abnormal_muscle_development0.08354642
118MP0008569_lethality_at_weaning0.07947048
119MP0000462_abnormal_digestive_system0.07916377
120MP0002166_altered_tumor_susceptibility0.07795750
121MP0001958_emphysema0.07057870
122MP0000013_abnormal_adipose_tissue0.07015589
123MP0006138_congestive_heart_failure0.06919906
124MP0009384_cardiac_valve_regurgitation0.06396915
125MP0001765_abnormal_ion_homeostasis0.06384583
126MP0000538_abnormal_urinary_bladder0.05519149
127MP0002090_abnormal_vision0.05461018
128MP0009703_decreased_birth_body0.03868802
129MP0009333_abnormal_splenocyte_physiolog0.03126099
130MP0001756_abnormal_urination0.02342708
131MP0005636_abnormal_mineral_homeostasis0.01504264
132MP0002118_abnormal_lipid_homeostasis0.01466291
133MP0009780_abnormal_chondrocyte_physiolo0.01180457
134MP0000685_abnormal_immune_system0.01091580
135MP0001186_pigmentation_phenotype0.00115405
136MP0005332_abnormal_amino_acid-0.0206956
137MP0005508_abnormal_skeleton_morphology-0.0156140
138MP0001881_abnormal_mammary_gland-0.0097934

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.24271424
2Nail dystrophy (HP:0008404)7.29839212
3Abnormality of nail color (HP:0100643)6.49098178
4Absent eyebrow (HP:0002223)6.41331364
5Abnormal hair laboratory examination (HP:0003328)5.84390700
6Fragile nails (HP:0001808)5.56002419
7Absent hair (HP:0002298)5.43402745
8Fine hair (HP:0002213)5.23256282
9Alopecia of scalp (HP:0002293)4.97017531
10Onycholysis (HP:0001806)4.96530900
11Palmoplantar hyperkeratosis (HP:0000972)4.94674912
12Increased IgE level (HP:0003212)4.83163084
13Thick nail (HP:0001805)4.73131728
14Palmar hyperkeratosis (HP:0010765)4.65584024
15Plantar hyperkeratosis (HP:0007556)4.48101874
16Follicular hyperkeratosis (HP:0007502)4.46186390
17Right ventricular cardiomyopathy (HP:0011663)4.30283321
18Abnormality of the axillary hair (HP:0100134)3.98322196
19Abnormality of secondary sexual hair (HP:0009888)3.98322196
20Erythema (HP:0010783)3.62245030
21Sparse eyelashes (HP:0000653)3.60910379
22Oral leukoplakia (HP:0002745)3.52769634
23Milia (HP:0001056)3.23160352
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.22573479
25Amelogenesis imperfecta (HP:0000705)3.09226342
26Abnormality of the frontal sinuses (HP:0002687)3.04661062
27Erythroderma (HP:0001019)2.93473429
28Parakeratosis (HP:0001036)2.86655021
29Curly hair (HP:0002212)2.71944201
30Ridged nail (HP:0001807)2.71747657
31Intention tremor (HP:0002080)2.68886024
32Congenital, generalized hypertrichosis (HP:0004540)2.66879630
33Natal tooth (HP:0000695)2.46429699
34Abnormal blistering of the skin (HP:0008066)2.46299629
35Neck muscle weakness (HP:0000467)2.46023918
36Torticollis (HP:0000473)2.40365583
37Advanced eruption of teeth (HP:0006288)2.37904119
38Congenital ichthyosiform erythroderma (HP:0007431)2.37526896
39Aplasia cutis congenita (HP:0001057)2.37076684
40Dry hair (HP:0011359)2.33392462
41Hypohidrosis (HP:0000966)2.10317024
42Ventricular tachycardia (HP:0004756)2.04789773
43Corneal erosion (HP:0200020)2.04772003
44Craniofacial dystonia (HP:0012179)2.03226257
45Palmoplantar keratoderma (HP:0000982)2.02467618
46Hypotrichosis (HP:0001006)14.6601837
47Woolly hair (HP:0002224)11.2207774
48Slow-growing hair (HP:0002217)11.0842496
49Abnormality of hair growth rate (HP:0011363)11.0842496
50Brittle hair (HP:0002299)10.2478175
51Pruritus (HP:0000989)1.93328098
52Coarse hair (HP:0002208)1.93166962
53Difficulty walking (HP:0002355)1.92445451
54Focal dystonia (HP:0004373)1.85974636
55Ventricular fibrillation (HP:0001663)1.85644239
56Abnormality of the pupil (HP:0000615)1.82782574
57Abnormality of permanent molar morphology (HP:0011071)1.73446080
58Abnormality of the dental root (HP:0006486)1.73446080
59Taurodontia (HP:0000679)1.73446080
60Abnormality of dental color (HP:0011073)1.70888572
61Abnormality of the parietal bone (HP:0002696)1.70860964
62Abnormality of molar (HP:0011077)1.70083848
63Abnormality of molar morphology (HP:0011070)1.70083848
64Fatigable weakness (HP:0003473)1.69743793
65Abnormality of the neuromuscular junction (HP:0003398)1.69743793
66Concave nail (HP:0001598)1.68440421
67Widely patent fontanelles and sutures (HP:0004492)1.63876507
68Absent eyelashes (HP:0000561)1.63147891
69Conjunctival hamartoma (HP:0100780)1.61611540
70Recurrent corneal erosions (HP:0000495)1.59890926
71Unilateral renal agenesis (HP:0000122)1.57927821
72Blepharitis (HP:0000498)1.56264642
73Abnormality of the aortic arch (HP:0012303)1.55189976
74Abnormality of the dental pulp (HP:0006479)1.51468081
75Sudden death (HP:0001699)1.49720236
76Hyporeflexia of lower limbs (HP:0002600)1.49599304
77Amniotic constriction ring (HP:0009775)1.46371877
78Abnormality of placental membranes (HP:0011409)1.46371877
79Acanthosis nigricans (HP:0000956)1.45410331
80Urticaria (HP:0001025)1.45399439
81Hypergammaglobulinemia (HP:0010702)1.42929953
82Carious teeth (HP:0000670)1.42244495
83Anonychia (HP:0001798)1.41504160
84Heterogeneous (HP:0001425)1.41103214
85Hamartoma of the eye (HP:0010568)1.40578939
86Furrowed tongue (HP:0000221)1.40249284
87Lip pit (HP:0100267)1.35300896
88Gangrene (HP:0100758)1.34927514
89Keratoconjunctivitis sicca (HP:0001097)1.33035915
90Ectropion (HP:0000656)1.31543155
91Laryngomalacia (HP:0001601)1.31201880
92Autoamputation (HP:0001218)1.30391692
93Achilles tendon contracture (HP:0001771)1.29489304
94Craniofacial hyperostosis (HP:0004493)1.29201391
95Neonatal onset (HP:0003623)1.29112092
96Abnormality of the fingernails (HP:0001231)1.28326288
97Distal lower limb muscle weakness (HP:0009053)1.25065217
98Abnormality of the Achilles tendon (HP:0005109)1.22028141
99Selective tooth agenesis (HP:0001592)1.19479935
100Variable expressivity (HP:0003828)1.18226007
101Sparse scalp hair (HP:0002209)1.18016134
102Keratoconjunctivitis (HP:0001096)1.16687693
103Widely spaced teeth (HP:0000687)1.15635444
104Hyperhidrosis (HP:0000975)1.15464103
105Corneal dystrophy (HP:0001131)1.13613205
106Abnormality of the gastric mucosa (HP:0004295)1.13469110
107Multifactorial inheritance (HP:0001426)1.13181973
108Lack of skin elasticity (HP:0100679)1.11292750
109Atrophic scars (HP:0001075)1.08808027
110Bronchomalacia (HP:0002780)1.08544438
111Dysdiadochokinesis (HP:0002075)0.90421058
112Generalized hyperpigmentation (HP:0007440)0.89850124
113Skin ulcer (HP:0200042)0.86903346
114Abnormality of the salivary glands (HP:0010286)0.86901472
115Acanthocytosis (HP:0001927)0.82331735
116Septate vagina (HP:0001153)0.82175088
117Aplasia involving bones of the extremities (HP:0009825)0.80374581
118Aplasia involving bones of the upper limbs (HP:0009823)0.80374581
119Aplasia of the phalanges of the hand (HP:0009802)0.80374581
120Cranial hyperostosis (HP:0004437)0.80197451
121Conical tooth (HP:0000698)0.75505534
122Dry skin (HP:0000958)0.75220845
123Hypoplastic toenails (HP:0001800)0.74927667
124Seborrheic dermatitis (HP:0001051)0.74665724
125Dehydration (HP:0001944)0.72710466
126Split foot (HP:0001839)0.70786610
127Delayed epiphyseal ossification (HP:0002663)0.70335657
128Breast hypoplasia (HP:0003187)0.69145309
129Xerostomia (HP:0000217)0.65940922
130Hypoplastic labia majora (HP:0000059)0.65431235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.32552016
2EPHA24.24598814
3MAPKAPK33.95639384
4ERN13.94188875
5MAP3K63.94113107
6MAP3K123.35246013
7TAOK33.12571443
8EPHB23.11403029
9TAOK13.10180938
10STK392.80509659
11MYLK2.79613737
12STK242.78943432
13TRIB32.77087625
14MAP3K32.71264518
15MAP3K22.34874758
16LATS12.23446470
17MAP3K112.10841687
18WNK42.09880243
19RPS6KB21.94489265
20EEF2K1.94002225
21EPHB11.82170418
22LMTK21.80470503
23OXSR11.71995135
24TTN1.70911281
25PIK3CG1.68349380
26MAP2K61.59626815
27MAPK71.59396855
28LATS21.55021640
29FGFR41.45289137
30BCR1.36181260
31MAP3K11.31104171
32PDK21.28505731
33PKN21.26597345
34NME11.26586407
35RIPK11.25272714
36BMX1.24436332
37KDR1.20688375
38MAPKAPK51.19332484
39KSR21.18766390
40BLK1.18373450
41MAP2K31.13337036
42CDK61.12387826
43FGFR21.11531516
44MST1R1.09586473
45MAPKAPK21.09241277
46FGFR11.09038963
47FGFR31.08872870
48PDGFRA1.08155357
49PTK61.03310552
50LRRK20.99361812
51MAP3K70.98379083
52MAP3K90.97295913
53MAPK150.94543147
54WNK10.91730829
55PINK10.90836064
56PRKD20.89810646
57SIK10.88588323
58ZAP700.86896725
59PTK20.85511384
60RPS6KA40.83555656
61MAP2K40.82595165
62PBK0.79263559
63PRPF4B0.79155204
64MAP3K130.78116725
65MAP3K100.75515655
66MAP2K10.75355307
67EPHA40.73492738
68MINK10.73401927
69PAK40.73280407
70STK380.73209293
71PAK30.69814994
72PIM20.69713211
73IKBKB0.69239344
74PRKD10.68502569
75TESK10.68227671
76MET0.68068107
77CDK190.66818288
78DYRK1B0.66499335
79CSK0.65513853
80DDR20.63594360
81TYK20.61570727
82CASK0.60648600
83JAK10.59156102
84STK38L0.57325199
85RPS6KB10.56812815
86PRKCH0.56048311
87ABL20.54631906
88PASK0.54529199
89SMG10.54265974
90PAK20.54084170
91TYRO30.54046576
92PRKCI0.53985343
93TRPM70.53558022
94ADRBK10.53425468
95PAK60.53390017
96OBSCN0.53376064
97EPHA30.53127937
98MAPK40.52970245
99RET0.52303253
100NTRK20.52114441
101MAP3K50.51679565
102ERBB40.51546633
103TNK20.50397713
104ERBB20.48410114
105TGFBR10.48032180
106SGK30.47561597
107ALK0.46709237
108RPS6KA10.46578555
109MAPK120.45105201
110CLK10.42520518
111GSK3A0.40274722
112SGK20.39425612
113GRK60.38899811
114CSNK1E0.38766116
115NEK60.37678097
116NEK10.37153178
117JAK20.36893295
118IGF1R0.35810086
119MAP2K20.35688757
120PRKCE0.35411218
121FES0.35333711
122KIT0.34321501
123FYN0.33462246
124MST40.33449328
125DAPK30.33446104
126MAP3K80.32621313
127PRKCD0.30944890
128TGFBR20.29229991
129SGK10.28593740
130CDC42BPA0.28490792
131LIMK10.26726497
132MAPK30.26161988
133PRKACA0.26076748
134HCK0.25618531
135SRC0.25498546
136PRKCA0.25257749
137STK110.24825908
138ILK0.24807476
139MAP4K10.24269629
140CSNK1A10.23920994
141ROCK10.23585972
142PRKACG0.22771696
143ICK0.22607163
144NTRK10.22519016
145MATK0.21690927
146PDPK10.21565546
147MAPK80.21154948
148SGK2230.21018353

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.92746028
2Linoleic acid metabolism_Homo sapiens_hsa005914.87687181
3Vitamin digestion and absorption_Homo sapiens_hsa049774.25039742
4Fat digestion and absorption_Homo sapiens_hsa049753.25965082
5Fatty acid biosynthesis_Homo sapiens_hsa000613.24693970
6Fatty acid elongation_Homo sapiens_hsa000622.83665304
7Ether lipid metabolism_Homo sapiens_hsa005652.58012067
8Basal cell carcinoma_Homo sapiens_hsa052172.14559475
9Retinol metabolism_Homo sapiens_hsa008301.99188676
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86158891
11Arachidonic acid metabolism_Homo sapiens_hsa005901.85869069
12Phenylalanine metabolism_Homo sapiens_hsa003601.85620203
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84197891
14Sphingolipid metabolism_Homo sapiens_hsa006001.83871751
15Glycerolipid metabolism_Homo sapiens_hsa005611.66331766
16VEGF signaling pathway_Homo sapiens_hsa043701.66104438
17Melanogenesis_Homo sapiens_hsa049161.52959655
18Axon guidance_Homo sapiens_hsa043601.52489077
19Caffeine metabolism_Homo sapiens_hsa002321.50554727
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37422106
21Histidine metabolism_Homo sapiens_hsa003401.35968346
22Hedgehog signaling pathway_Homo sapiens_hsa043401.31580367
23Glioma_Homo sapiens_hsa052141.31404531
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.29108893
25Thyroid cancer_Homo sapiens_hsa052161.27120636
26Bladder cancer_Homo sapiens_hsa052191.26921037
27Proteoglycans in cancer_Homo sapiens_hsa052051.24040983
28Acute myeloid leukemia_Homo sapiens_hsa052211.23703083
29Hippo signaling pathway_Homo sapiens_hsa043901.18381966
30GnRH signaling pathway_Homo sapiens_hsa049121.16917660
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14583980
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12546057
33Pancreatic secretion_Homo sapiens_hsa049721.10129138
34Steroid biosynthesis_Homo sapiens_hsa001001.08466849
35Tight junction_Homo sapiens_hsa045301.08302610
36Dorso-ventral axis formation_Homo sapiens_hsa043201.08225139
37PPAR signaling pathway_Homo sapiens_hsa033201.07554600
38Mineral absorption_Homo sapiens_hsa049781.06452225
39Nitrogen metabolism_Homo sapiens_hsa009101.05990599
40Long-term potentiation_Homo sapiens_hsa047200.97202042
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95755595
42Adherens junction_Homo sapiens_hsa045200.95537772
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94161032
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.93666774
45ECM-receptor interaction_Homo sapiens_hsa045120.93128634
46Tyrosine metabolism_Homo sapiens_hsa003500.91391752
47Collecting duct acid secretion_Homo sapiens_hsa049660.89351275
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85934601
49Pertussis_Homo sapiens_hsa051330.85230458
50Peroxisome_Homo sapiens_hsa041460.84894240
51Non-small cell lung cancer_Homo sapiens_hsa052230.84782605
52Endometrial cancer_Homo sapiens_hsa052130.83610313
53beta-Alanine metabolism_Homo sapiens_hsa004100.81222987
54Estrogen signaling pathway_Homo sapiens_hsa049150.81205241
55Ras signaling pathway_Homo sapiens_hsa040140.80941962
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80440857
57Ovarian steroidogenesis_Homo sapiens_hsa049130.79212562
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.78284366
59Long-term depression_Homo sapiens_hsa047300.77928217
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77697840
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77572590
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75629754
63Amoebiasis_Homo sapiens_hsa051460.75240829
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74376130
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72048040
66Wnt signaling pathway_Homo sapiens_hsa043100.71533901
67Pyruvate metabolism_Homo sapiens_hsa006200.69258423
68Staphylococcus aureus infection_Homo sapiens_hsa051500.68459550
69Gastric acid secretion_Homo sapiens_hsa049710.67705301
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.67596883
71Lysosome_Homo sapiens_hsa041420.63228321
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62698372
73Renin secretion_Homo sapiens_hsa049240.61746115
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.61016685
75Fatty acid metabolism_Homo sapiens_hsa012120.60356698
76Insulin resistance_Homo sapiens_hsa049310.59223903
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59122900
78Hepatitis C_Homo sapiens_hsa051600.58444811
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57779897
80Propanoate metabolism_Homo sapiens_hsa006400.57336994
81Phototransduction_Homo sapiens_hsa047440.57167052
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56937071
83MicroRNAs in cancer_Homo sapiens_hsa052060.56444586
84Amphetamine addiction_Homo sapiens_hsa050310.56387535
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.55111951
86Rap1 signaling pathway_Homo sapiens_hsa040150.53853741
87Gap junction_Homo sapiens_hsa045400.53207003
88Salmonella infection_Homo sapiens_hsa051320.52783212
89Salivary secretion_Homo sapiens_hsa049700.50997997
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48271152
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47850525
92Focal adhesion_Homo sapiens_hsa045100.47726841
93Renal cell carcinoma_Homo sapiens_hsa052110.47416862
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.47125427
95Fatty acid degradation_Homo sapiens_hsa000710.46451646
96Serotonergic synapse_Homo sapiens_hsa047260.46208488
97Oxytocin signaling pathway_Homo sapiens_hsa049210.45635863
98ErbB signaling pathway_Homo sapiens_hsa040120.45454030
99Butanoate metabolism_Homo sapiens_hsa006500.45304227
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45166987
101Platelet activation_Homo sapiens_hsa046110.44958594
102Protein digestion and absorption_Homo sapiens_hsa049740.42323475
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42180403
104Chemical carcinogenesis_Homo sapiens_hsa052040.41483330
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40564210
106Prion diseases_Homo sapiens_hsa050200.40477484
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.39957308
108Toxoplasmosis_Homo sapiens_hsa051450.39744611
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39618620
110Circadian entrainment_Homo sapiens_hsa047130.39173281
111Tuberculosis_Homo sapiens_hsa051520.38930577
112TGF-beta signaling pathway_Homo sapiens_hsa043500.37723344
113Olfactory transduction_Homo sapiens_hsa047400.37458720
114Prolactin signaling pathway_Homo sapiens_hsa049170.37057228
115Notch signaling pathway_Homo sapiens_hsa043300.37003277
116Chronic myeloid leukemia_Homo sapiens_hsa052200.36879418
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36483819
118Arginine biosynthesis_Homo sapiens_hsa002200.35815125
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35089060
120Insulin signaling pathway_Homo sapiens_hsa049100.33912198
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33339641
122Calcium signaling pathway_Homo sapiens_hsa040200.33143990
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.33090031
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29138519
125Malaria_Homo sapiens_hsa051440.28198935
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27326180
127Asthma_Homo sapiens_hsa053100.25864624
128Dopaminergic synapse_Homo sapiens_hsa047280.25526759
129Glucagon signaling pathway_Homo sapiens_hsa049220.23986854
130Tryptophan metabolism_Homo sapiens_hsa003800.21463681
131Glutamatergic synapse_Homo sapiens_hsa047240.17895627
132Taste transduction_Homo sapiens_hsa047420.16879429
133Rheumatoid arthritis_Homo sapiens_hsa053230.14524531
134Vibrio cholerae infection_Homo sapiens_hsa051100.12191415
135Phagosome_Homo sapiens_hsa041450.11551349
136Alzheimers disease_Homo sapiens_hsa050100.10913515
137Graft-versus-host disease_Homo sapiens_hsa053320.10815408
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.10760160
139Synaptic vesicle cycle_Homo sapiens_hsa047210.10512657
140Allograft rejection_Homo sapiens_hsa053300.09335401
141Autoimmune thyroid disease_Homo sapiens_hsa053200.09019620
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.07562173

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