KRTAP4-8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1citrulline biosynthetic process (GO:0019240)9.76252540
2adhesion of symbiont to host (GO:0044406)9.39028932
3hair follicle morphogenesis (GO:0031069)8.72321495
4peptide cross-linking (GO:0018149)8.71889815
5intermediate filament cytoskeleton organization (GO:0045104)6.94548576
6intermediate filament-based process (GO:0045103)6.72473361
7citrulline metabolic process (GO:0000052)6.47422835
8cell wall macromolecule metabolic process (GO:0044036)6.28037166
9cell wall macromolecule catabolic process (GO:0016998)6.28037166
10epidermis development (GO:0008544)6.13818846
11keratinocyte differentiation (GO:0030216)5.90909320
12bundle of His cell to Purkinje myocyte communication (GO:0086069)5.60313247
13hair cycle process (GO:0022405)5.57769368
14molting cycle process (GO:0022404)5.57769368
15peptidyl-arginine modification (GO:0018195)5.41123820
16establishment of skin barrier (GO:0061436)5.30429398
17skin morphogenesis (GO:0043589)5.19849696
18hemidesmosome assembly (GO:0031581)4.92963304
19regulation of water loss via skin (GO:0033561)4.73054088
20epidermal cell differentiation (GO:0009913)4.60865525
21* molting cycle (GO:0042303)33.4018074
22* hair cycle (GO:0042633)33.4018074
23tooth mineralization (GO:0034505)3.98901445
24keratinocyte development (GO:0003334)3.92237643
25negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.51995191
26negative regulation of keratinocyte proliferation (GO:0010839)3.45044288
27phosphatidylinositol acyl-chain remodeling (GO:0036149)3.33235014
28hair follicle development (GO:0001942)3.24786149
29positive regulation of hair cycle (GO:0042635)3.21937657
30positive regulation of hair follicle development (GO:0051798)3.21937657
31multicellular organismal water homeostasis (GO:0050891)3.20447043
32regulation of keratinocyte differentiation (GO:0045616)3.15737881
33phosphatidylserine acyl-chain remodeling (GO:0036150)3.04473061
34regulation of hair follicle development (GO:0051797)3.04228033
35epithelium development (GO:0060429)2.91450030
36negative regulation of protein localization to plasma membrane (GO:1903077)2.90823943
37gap junction assembly (GO:0016264)2.87677883
38ectoderm development (GO:0007398)2.86392021
39atrioventricular valve morphogenesis (GO:0003181)2.85772372
40phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77301756
41positive regulation of epidermis development (GO:0045684)2.77054237
42bone trabecula formation (GO:0060346)2.74798595
43regulation of hair cycle (GO:0042634)2.69662482
44fatty acid elongation (GO:0030497)2.67936260
45positive regulation of meiotic cell cycle (GO:0051446)2.63130019
46water homeostasis (GO:0030104)2.61423094
47ventricular cardiac muscle cell action potential (GO:0086005)2.60474161
48regulation of epidermal cell differentiation (GO:0045604)2.47903556
49negative regulation of cell fate specification (GO:0009996)2.46743960
50regulation of epidermis development (GO:0045682)2.43518489
51lymph vessel development (GO:0001945)2.42666303
52epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.36591142
53phosphatidylserine metabolic process (GO:0006658)2.32408406
54regulation of mesenchymal cell apoptotic process (GO:2001053)2.30607431
55positive regulation of epidermal cell differentiation (GO:0045606)2.28314393
56skin development (GO:0043588)2.25664259
57cell surface receptor signaling pathway involved in heart development (GO:0061311)2.23869591
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.20681830
59phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.19858033
60regulation of cardioblast differentiation (GO:0051890)2.19438118
61regulation of heart rate by cardiac conduction (GO:0086091)2.18064875
62epithelial cell-cell adhesion (GO:0090136)2.16056813
63wound healing, spreading of epidermal cells (GO:0035313)2.13904584
64myotube differentiation (GO:0014902)2.11408567
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.07858416
66cell communication involved in cardiac conduction (GO:0086065)2.07268259
67cranial suture morphogenesis (GO:0060363)2.05885636
68outflow tract septum morphogenesis (GO:0003148)2.04789086
69positive regulation of monocyte chemotaxis (GO:0090026)2.04675957
70intermediate filament organization (GO:0045109)12.7707683
71keratinization (GO:0031424)11.2577897
72adhesion of symbiont to host cell (GO:0044650)11.1085355
73virion attachment to host cell (GO:0019062)11.1085355
74desmosome organization (GO:0002934)10.5733467
75planar cell polarity pathway involved in neural tube closure (GO:0090179)1.97601462
76phosphatidylcholine acyl-chain remodeling (GO:0036151)1.93696568
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.92482870
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.92482870
79regulation of keratinocyte proliferation (GO:0010837)1.92143128
80regulation of ruffle assembly (GO:1900027)1.91469175
81negative regulation of epidermis development (GO:0045683)1.90514939
82coronary vasculature morphogenesis (GO:0060977)1.87610224
83ephrin receptor signaling pathway (GO:0048013)1.85592784
84cell-substrate junction assembly (GO:0007044)1.82991607
85regulation of secondary heart field cardioblast proliferation (GO:0003266)1.82387981
86regulation of cardioblast proliferation (GO:0003264)1.82387981
87regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.81507915
88non-canonical Wnt signaling pathway (GO:0035567)1.81332907
89* aging (GO:0007568)1.80279298
90alditol phosphate metabolic process (GO:0052646)1.72133733
91outer ear morphogenesis (GO:0042473)1.70983282
92cardiac conduction (GO:0061337)1.70778803
93negative regulation of cell fate commitment (GO:0010454)1.69959987
94very long-chain fatty acid metabolic process (GO:0000038)1.68753005
95cellular modified amino acid biosynthetic process (GO:0042398)1.68439098
96primary alcohol catabolic process (GO:0034310)1.67350242
97cardiac muscle cell action potential involved in contraction (GO:0086002)1.65949528
98regulation of transforming growth factor beta2 production (GO:0032909)1.64233785
99G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.60259853
100establishment of planar polarity (GO:0001736)1.60100786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.39528060
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.77850996
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.31949421
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68544079
5CTCF_20526341_ChIP-Seq_ESCs_Human2.29694871
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.20902598
7* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.09567322
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00692224
9TP63_17297297_ChIP-ChIP_HaCaT_Human12.4843868
10E2F1_20622854_ChIP-Seq_HELA_Human1.83489992
11TAF2_19829295_ChIP-Seq_ESCs_Human1.80730222
12EGR1_19032775_ChIP-ChIP_M12_Human1.75921004
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.73602371
14CSB_26484114_Chip-Seq_FIBROBLAST_Human1.70878612
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.69041849
16NANOG_20526341_ChIP-Seq_ESCs_Human1.68922143
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68742287
18CTCF_27219007_Chip-Seq_Bcells_Human1.61475010
19LXR_22292898_ChIP-Seq_THP-1_Human1.55939677
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.54326918
21MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.54119127
22RACK7_27058665_Chip-Seq_MCF-7_Human1.52764621
23ERG_20517297_ChIP-Seq_VCAP_Human1.52751886
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.52669074
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51682549
26P53_21459846_ChIP-Seq_SAOS-2_Human1.51211444
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50413735
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50413735
29TP63_22573176_ChIP-Seq_HFKS_Human1.47398384
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43244338
31BCL6_27268052_Chip-Seq_Bcells_Human1.41744639
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40102728
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.38780066
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.36833251
35ATF3_27146783_Chip-Seq_COLON_Human1.36650548
36BCOR_27268052_Chip-Seq_Bcells_Human1.33931279
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.33814058
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32257468
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27278101
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26690841
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25533805
42PHF8_20622854_ChIP-Seq_HELA_Human1.24201382
43* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22289380
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21921181
45ARNT_22903824_ChIP-Seq_MCF-7_Human1.21674949
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16851827
47AHR_22903824_ChIP-Seq_MCF-7_Human1.16572398
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16160177
49P68_20966046_ChIP-Seq_HELA_Human1.14413265
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13567643
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13100198
52CEBPB_22108803_ChIP-Seq_LS180_Human1.12963025
53SMC4_20622854_ChIP-Seq_HELA_Human1.12802365
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.12345403
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11827899
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10766998
57RAC3_21632823_ChIP-Seq_H3396_Human1.10373320
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.09426318
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.07764007
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.06925908
61GATA4_25053715_ChIP-Seq_YYC3_Human1.06193092
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05733019
63ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05381507
64TP63_23658742_ChIP-Seq_EP156T_Human1.03941398
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02329432
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.00440701
67SPI1_20517297_ChIP-Seq_HL60_Human0.99883862
68KLF5_25053715_ChIP-Seq_YYC3_Human0.99449551
69SOX2_21211035_ChIP-Seq_LN229_Human0.97472724
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97455992
71ERG_21242973_ChIP-ChIP_JURKAT_Human0.96140601
72* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95416632
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94667722
74GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94335651
75* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91456064
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90994072
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90971401
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90956836
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.90953718
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89415859
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.89316889
82RING1B_27294783_Chip-Seq_ESCs_Mouse0.88925892
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88511866
84RUNX1_27514584_Chip-Seq_MCF-7_Human0.87782000
85TP53_18474530_ChIP-ChIP_U2OS_Human0.86368151
86RXR_22108803_ChIP-Seq_LS180_Human0.85878380
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.84328557
88SOX2_20726797_ChIP-Seq_SW620_Human0.84222032
89RNF2_27304074_Chip-Seq_ESCs_Mouse0.83683874
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83271880
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.80913082
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80815797
93ZNF263_19887448_ChIP-Seq_K562_Human0.79730773
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.78661693
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77660470
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76803698
97AR_21572438_ChIP-Seq_LNCaP_Human0.76365163
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75488078
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74432702
100SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.72420141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.76422518
2MP0002098_abnormal_vibrissa_morphology7.23104447
3MP0000647_abnormal_sebaceous_gland6.48330674
4MP0002796_impaired_skin_barrier5.74688872
5MP0010234_abnormal_vibrissa_follicle5.37560356
6MP0005275_abnormal_skin_tensile5.11682492
7MP0000383_abnormal_hair_follicle4.47815167
8MP0000377_abnormal_hair_follicle4.10094536
9MP0010678_abnormal_skin_adnexa4.05190984
10MP0003705_abnormal_hypodermis_morpholog3.81130683
11MP0005501_abnormal_skin_physiology3.63875096
12MP0000427_abnormal_hair_cycle3.57215235
13MP0002254_reproductive_system_inflammat2.89246330
14MP0001216_abnormal_epidermal_layer2.61692915
15MP0004381_abnormal_hair_follicle2.45855764
16MP0000367_abnormal_coat/_hair2.35682491
17MP0004947_skin_inflammation2.25181383
18MP0010771_integument_phenotype2.25177144
19MP0003453_abnormal_keratinocyte_physiol2.18823550
20MP0001243_abnormal_dermal_layer2.17486529
21MP0002060_abnormal_skin_morphology2.13211841
22MP0002234_abnormal_pharynx_morphology2.08462112
23MP0000467_abnormal_esophagus_morphology1.72418444
24MP0009053_abnormal_anal_canal1.49091824
25MP0009931_abnormal_skin_appearance1.45744803
26MP0000762_abnormal_tongue_morphology1.45711026
27MP0003566_abnormal_cell_adhesion1.45492656
28MP0005409_darkened_coat_color1.36617896
29MP0003941_abnormal_skin_development1.02876345
30MP0001191_abnormal_skin_condition0.97189131
31MP0004885_abnormal_endolymph0.95083341
32MP0001851_eye_inflammation0.89183729
33MP0004185_abnormal_adipocyte_glucose0.84164812
34MP0004264_abnormal_extraembryonic_tissu0.81277331
35MP0002095_abnormal_skin_pigmentation0.74212365
36MP0001661_extended_life_span0.72459014
37MP0008438_abnormal_cutaneous_collagen0.72448402
38MP0001849_ear_inflammation0.67565225
39MP0001340_abnormal_eyelid_morphology0.64601422
40MP0003315_abnormal_perineum_morphology0.64134979
41MP0001346_abnormal_lacrimal_gland0.60884603
42MP0002877_abnormal_melanocyte_morpholog0.60846906
43MP0000627_abnormal_mammary_gland0.56308503
44MP0010030_abnormal_orbit_morphology0.53324361
45MP0010352_gastrointestinal_tract_polyps0.52147523
46MP0003191_abnormal_cellular_cholesterol0.51798896
47MP0002282_abnormal_trachea_morphology0.50849405
48MP0005023_abnormal_wound_healing0.50073965
49MP0000566_synostosis0.49371496
50MP0002970_abnormal_white_adipose0.48437541
51MP0003755_abnormal_palate_morphology0.47113393
52MP0002249_abnormal_larynx_morphology0.44813510
53MP0005451_abnormal_body_composition0.44327441
54MP0001784_abnormal_fluid_regulation0.43776393
55MP0000678_abnormal_parathyroid_gland0.42844557
56MP0002111_abnormal_tail_morphology0.37699283
57MP0005075_abnormal_melanosome_morpholog0.34503347
58MP0009840_abnormal_foam_cell0.34344224
59MP0004272_abnormal_basement_membrane0.32640513
60MP0000465_gastrointestinal_hemorrhage0.30695709
61MP0003385_abnormal_body_wall0.28285585
62MP0003763_abnormal_thymus_physiology0.26929800
63MP0000537_abnormal_urethra_morphology0.26252348
64MP0003329_amyloid_beta_deposits0.25300888
65MP0003950_abnormal_plasma_membrane0.24755879
66MP0003300_gastrointestinal_ulcer0.24479789
67MP0000516_abnormal_urinary_system0.23669050
68MP0005367_renal/urinary_system_phenotyp0.23669050
69MP0002177_abnormal_outer_ear0.22565556
70MP0002697_abnormal_eye_size0.22286550
71MP0005248_abnormal_Harderian_gland0.21951759
72MP0004019_abnormal_vitamin_homeostasis0.20469536
73MP0006054_spinal_hemorrhage0.19110457
74MP0001879_abnormal_lymphatic_vessel0.18976755
75MP0004742_abnormal_vestibular_system0.18110748
76MP0003075_altered_response_to0.16225800
77MP0004858_abnormal_nervous_system0.15939449
78MP0005375_adipose_tissue_phenotype0.15911967
79MP0002166_altered_tumor_susceptibility0.15804586
80MP0000432_abnormal_head_morphology0.15616062
81MP0002006_tumorigenesis0.15470185
82MP0005666_abnormal_adipose_tissue0.15338522
83MP0003448_altered_tumor_morphology0.14420760
84MP0003935_abnormal_craniofacial_develop0.13216150
85MP0003011_delayed_dark_adaptation0.13182431
86MP0000604_amyloidosis0.12650059
87MP0003638_abnormal_response/metabolism_0.12559264
88MP0005076_abnormal_cell_differentiation0.11033535
89MP0002233_abnormal_nose_morphology0.09638589
90MP0005193_abnormal_anterior_eye0.09478095
91MP0003045_fibrosis0.09223503
92MP0000733_abnormal_muscle_development0.08666391
93MP0008569_lethality_at_weaning0.08346574
94MP0010368_abnormal_lymphatic_system0.08144750
95MP0000013_abnormal_adipose_tissue0.07958210
96MP0000462_abnormal_digestive_system0.07598579
97MP0006138_congestive_heart_failure0.07472082
98MP0001958_emphysema0.07462285
99MP0005623_abnormal_meninges_morphology0.06837576
100MP0000751_myopathy0.06096865

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.86715914
2Pili torti (HP:0003777)9.42360217
3Nail dystrophy (HP:0008404)7.12152326
4Abnormality of nail color (HP:0100643)6.39983834
5Abnormal hair laboratory examination (HP:0003328)5.94157259
6Fragile nails (HP:0001808)5.55944989
7Fine hair (HP:0002213)5.11231925
8Onycholysis (HP:0001806)5.08223715
9Palmoplantar hyperkeratosis (HP:0000972)4.92432044
10Alopecia of scalp (HP:0002293)4.91182558
11Increased IgE level (HP:0003212)4.81646801
12Palmar hyperkeratosis (HP:0010765)4.63020703
13Thick nail (HP:0001805)4.62591549
14Plantar hyperkeratosis (HP:0007556)4.46540701
15Right ventricular cardiomyopathy (HP:0011663)4.44982040
16Follicular hyperkeratosis (HP:0007502)4.44897093
17Sparse eyelashes (HP:0000653)3.65798554
18Erythema (HP:0010783)3.59213964
19Oral leukoplakia (HP:0002745)3.55186651
20Milia (HP:0001056)3.24906023
21Amelogenesis imperfecta (HP:0000705)3.14763774
22Abnormality of the frontal sinuses (HP:0002687)3.09563417
23Parakeratosis (HP:0001036)2.86138142
24Intention tremor (HP:0002080)2.82442249
25Erythroderma (HP:0001019)2.80674434
26Curly hair (HP:0002212)2.74530971
27Congenital, generalized hypertrichosis (HP:0004540)2.68538781
28Ridged nail (HP:0001807)2.65321046
29Neck muscle weakness (HP:0000467)2.56200861
30Natal tooth (HP:0000695)2.50431365
31Torticollis (HP:0000473)2.47344473
32Advanced eruption of teeth (HP:0006288)2.43542706
33Abnormal blistering of the skin (HP:0008066)2.42246528
34Aplasia cutis congenita (HP:0001057)2.40246970
35Dry hair (HP:0011359)2.30319044
36Congenital ichthyosiform erythroderma (HP:0007431)2.27001548
37Ventricular tachycardia (HP:0004756)2.11175408
38Craniofacial dystonia (HP:0012179)2.08792932
39Hypohidrosis (HP:0000966)2.06019202
40Corneal erosion (HP:0200020)2.01347797
41Hypotrichosis (HP:0001006)14.3718824
42Woolly hair (HP:0002224)11.4936054
43Slow-growing hair (HP:0002217)10.8347581
44Abnormality of hair growth rate (HP:0011363)10.8347581
45Palmoplantar keratoderma (HP:0000982)1.99776547
46Difficulty walking (HP:0002355)1.97872492
47Pruritus (HP:0000989)1.93605270
48Abnormality of the pupil (HP:0000615)1.91771457
49Focal dystonia (HP:0004373)1.91132536
50Ventricular fibrillation (HP:0001663)1.90915010
51Abnormality of the parietal bone (HP:0002696)1.77520597
52Abnormality of the dental root (HP:0006486)1.76242225
53Taurodontia (HP:0000679)1.76242225
54Abnormality of permanent molar morphology (HP:0011071)1.76242225
55Abnormality of molar morphology (HP:0011070)1.73048962
56Abnormality of molar (HP:0011077)1.73048962
57Abnormality of dental color (HP:0011073)1.70996262
58Fatigable weakness (HP:0003473)1.67271530
59Abnormality of the neuromuscular junction (HP:0003398)1.67271530
60Concave nail (HP:0001598)1.64567236
61Absent eyelashes (HP:0000561)1.63407238
62Widely patent fontanelles and sutures (HP:0004492)1.63153310
63Unilateral renal agenesis (HP:0000122)1.62760534
64Recurrent corneal erosions (HP:0000495)1.62552753
65Conjunctival hamartoma (HP:0100780)1.60543454
66Abnormality of the aortic arch (HP:0012303)1.59627931
67Blepharitis (HP:0000498)1.56389099
68Abnormality of the dental pulp (HP:0006479)1.53974242
69Hyporeflexia of lower limbs (HP:0002600)1.53262856
70Sudden death (HP:0001699)1.53196340
71Acanthosis nigricans (HP:0000956)1.52731630
72Abnormality of placental membranes (HP:0011409)1.52564805
73Amniotic constriction ring (HP:0009775)1.52564805
74Hypergammaglobulinemia (HP:0010702)1.45008983
75Carious teeth (HP:0000670)1.43105741
76Anonychia (HP:0001798)1.41757682
77Craniofacial hyperostosis (HP:0004493)1.38889779
78Heterogeneous (HP:0001425)1.36905563
79Lip pit (HP:0100267)1.33964933
80Keratoconjunctivitis sicca (HP:0001097)1.33627399
81Laryngomalacia (HP:0001601)1.28894956
82Autoamputation (HP:0001218)1.28849122
83Achilles tendon contracture (HP:0001771)1.27993343
84Ectropion (HP:0000656)1.27680001
85Gangrene (HP:0100758)1.27301622
86Neonatal onset (HP:0003623)1.26430874
87Abnormality of the fingernails (HP:0001231)1.25371632
88Distal lower limb muscle weakness (HP:0009053)1.23806126
89Selective tooth agenesis (HP:0001592)1.21507883
90Abnormality of the Achilles tendon (HP:0005109)1.20883588
91Widely spaced teeth (HP:0000687)1.17644043
92Keratoconjunctivitis (HP:0001096)1.17049084
93Abnormality of the gastric mucosa (HP:0004295)1.16815461
94Hyperthyroidism (HP:0000836)1.16786996
95Sparse scalp hair (HP:0002209)1.16424902
96Furrowed tongue (HP:0000221)1.13783696
97Hyperhidrosis (HP:0000975)1.13242931
98Variable expressivity (HP:0003828)1.13212454
99Bronchomalacia (HP:0002780)1.11709589
100Corneal dystrophy (HP:0001131)1.11282144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.44850045
2EPHA24.11668571
3MAP3K63.90246083
4ERN13.83721310
5MAPKAPK33.76700025
6EPHB23.14613593
7TAOK13.05502544
8TRIB32.77319560
9MAP3K32.54541164
10MAP3K22.34434558
11LATS12.10641910
12MAP3K112.05077624
13FGFR22.02730847
14EEF2K1.98144260
15RPS6KB21.89282314
16EPHB11.84427510
17TTN1.81536189
18PIK3CG1.73009841
19MAP2K61.53106472
20LATS21.52446720
21FGFR31.45204544
22FGFR41.43928110
23BCR1.34618125
24MAP3K11.30202493
25PKN21.28331928
26BMX1.23206254
27RIPK11.22352131
28NME11.19767979
29KSR21.19602727
30BLK1.15953068
31MAPKAPK21.05825882
32CDK61.05564097
33MAP2K31.04169887
34PTK61.03918675
35PDGFRA1.02565263
36SIK11.01286757
37MST1R0.98219216
38MAP3K70.95625875
39LRRK20.93933256
40FGFR10.89705193
41MAP3K90.88805079
42PTK20.83687834
43MAP2K40.77841520
44MAP3K100.77352196
45FRK0.73710185
46CDK190.71757701
47MAP2K10.71448241
48PAK40.71153724
49STK380.70677046
50RPS6KA40.70190745
51OBSCN0.69023771
52PAK30.68462995
53PRKD10.67040002
54PIM20.64887522
55PBK0.64251697
56TYK20.63809601
57DYRK1B0.63061536
58FES0.61605561
59DDR20.61507795
60MET0.61505976
61TESK10.58795061
62PRKCH0.58544881
63JAK10.57816219
64TRPM70.57114081
65PAK20.54122294
66PRKCI0.53747794
67STK38L0.53591837
68RET0.52733679
69EPHA30.52388517
70PAK60.51813196
71ALK0.49110319
72NTRK20.49021470
73MAPK120.48281095
74TYRO30.47965944
75TGFBR10.47549588
76ERBB40.47252240
77ERBB20.45952516
78MAP3K50.45400297
79RPS6KA10.45096235
80CLK10.44655224
81GSK3A0.40077605
82CSNK1E0.38048073
83GRK60.37445220
84STK110.37208836
85JAK20.35774065
86MAP2K20.34055136
87FYN0.33543782
88MAP3K80.31234663
89HCK0.30608708
90SRC0.27791663
91TGFBR20.27312402
92ICK0.26824602
93MAP4K10.26170940
94MATK0.25883400
95NEK10.25833169
96LIMK10.25825686
97NTRK10.23106808
98PRKACG0.22852562
99PHKG10.22444159
100PHKG20.22444159

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.74080719
2Linoleic acid metabolism_Homo sapiens_hsa005914.69164712
3Fat digestion and absorption_Homo sapiens_hsa049753.20258383
4Fatty acid elongation_Homo sapiens_hsa000622.78947040
5Ether lipid metabolism_Homo sapiens_hsa005652.46184852
6Basal cell carcinoma_Homo sapiens_hsa052172.17940911
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93083621
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.83979914
9Phenylalanine metabolism_Homo sapiens_hsa003601.83008562
10Arachidonic acid metabolism_Homo sapiens_hsa005901.76127722
11VEGF signaling pathway_Homo sapiens_hsa043701.64193528
12Caffeine metabolism_Homo sapiens_hsa002321.60912335
13Axon guidance_Homo sapiens_hsa043601.59462580
14Melanogenesis_Homo sapiens_hsa049161.52360958
15Glioma_Homo sapiens_hsa052141.39212254
16Hedgehog signaling pathway_Homo sapiens_hsa043401.33572977
17Histidine metabolism_Homo sapiens_hsa003401.30178583
18Acute myeloid leukemia_Homo sapiens_hsa052211.27732986
19Thyroid cancer_Homo sapiens_hsa052161.25277102
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.25264190
21Proteoglycans in cancer_Homo sapiens_hsa052051.24341515
22Bladder cancer_Homo sapiens_hsa052191.22832773
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20562852
24Hippo signaling pathway_Homo sapiens_hsa043901.16073728
25Dorso-ventral axis formation_Homo sapiens_hsa043201.15599473
26GnRH signaling pathway_Homo sapiens_hsa049121.14412202
27Mineral absorption_Homo sapiens_hsa049781.13181238
28Tight junction_Homo sapiens_hsa045301.12872183
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10603910
30Pancreatic secretion_Homo sapiens_hsa049721.08160556
31Nitrogen metabolism_Homo sapiens_hsa009101.07729529
32PPAR signaling pathway_Homo sapiens_hsa033201.06312805
33Steroid biosynthesis_Homo sapiens_hsa001001.03792238
34Adherens junction_Homo sapiens_hsa045201.00696034
35Endometrial cancer_Homo sapiens_hsa052130.95287589
36Long-term potentiation_Homo sapiens_hsa047200.94276704
37ECM-receptor interaction_Homo sapiens_hsa045120.93457903
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92150535
39Non-small cell lung cancer_Homo sapiens_hsa052230.89430896
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.87588476
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87066693
42Tyrosine metabolism_Homo sapiens_hsa003500.86336380
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84372294
44Pertussis_Homo sapiens_hsa051330.84195928
45Estrogen signaling pathway_Homo sapiens_hsa049150.83280527
46Leukocyte transendothelial migration_Homo sapiens_hsa046700.82479511
47beta-Alanine metabolism_Homo sapiens_hsa004100.81805298
48Ras signaling pathway_Homo sapiens_hsa040140.81535029
49Long-term depression_Homo sapiens_hsa047300.78789802
50Amoebiasis_Homo sapiens_hsa051460.76861319
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76526147
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73608590
53Gastric acid secretion_Homo sapiens_hsa049710.70564315
54Wnt signaling pathway_Homo sapiens_hsa043100.69892868
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63669176
56Insulin resistance_Homo sapiens_hsa049310.63484282
57Renin secretion_Homo sapiens_hsa049240.62907727
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.62293161
59Staphylococcus aureus infection_Homo sapiens_hsa051500.61952474
60Fatty acid metabolism_Homo sapiens_hsa012120.60394492
61Gap junction_Homo sapiens_hsa045400.59432661
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.59301678
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59178376
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58161003
65MicroRNAs in cancer_Homo sapiens_hsa052060.57845081
66Rap1 signaling pathway_Homo sapiens_hsa040150.56628739
67Hepatitis C_Homo sapiens_hsa051600.56542969
68Focal adhesion_Homo sapiens_hsa045100.54600900
69Renal cell carcinoma_Homo sapiens_hsa052110.54115705
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.53615865
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.53419482
72Salivary secretion_Homo sapiens_hsa049700.52770191
73Salmonella infection_Homo sapiens_hsa051320.52670874
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49318531
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49141314
76Phototransduction_Homo sapiens_hsa047440.48921258
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48721527
78Platelet activation_Homo sapiens_hsa046110.48551888
79Butanoate metabolism_Homo sapiens_hsa006500.48304922
80Oxytocin signaling pathway_Homo sapiens_hsa049210.46325557
81Fatty acid degradation_Homo sapiens_hsa000710.45743245
82ErbB signaling pathway_Homo sapiens_hsa040120.45314196
83Toxoplasmosis_Homo sapiens_hsa051450.43222747
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42391781
85Prion diseases_Homo sapiens_hsa050200.41281491
86Protein digestion and absorption_Homo sapiens_hsa049740.41071320
87Chemical carcinogenesis_Homo sapiens_hsa052040.40998506
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39616839
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39325566
90Chronic myeloid leukemia_Homo sapiens_hsa052200.38764580
91Arginine biosynthesis_Homo sapiens_hsa002200.38359447
92Melanoma_Homo sapiens_hsa052180.38010676
93Prolactin signaling pathway_Homo sapiens_hsa049170.37730706
94Notch signaling pathway_Homo sapiens_hsa043300.37435499
95Olfactory transduction_Homo sapiens_hsa047400.36208048
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.35848810
97Tuberculosis_Homo sapiens_hsa051520.35243746
98TGF-beta signaling pathway_Homo sapiens_hsa043500.35048122
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35005270
100Bile secretion_Homo sapiens_hsa049760.34418274

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