ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	hair cycle (GO:0042633)	8.59079700
2	molting cycle (GO:0042303)	8.59079700
3	central nervous system myelination (GO:0022010)	7.45092397
4	axon ensheathment in central nervous system (GO:0032291)	7.45092397
5	viral transcription (GO:0019083)	7.38179513
6	translational termination (GO:0006415)	7.27628674
7	ribosomal small subunit assembly (GO:0000028)	6.50752225
8	maturation of SSU-rRNA (GO:0030490)	6.45861235
9	viral protein processing (GO:0019082)	6.25587202
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.07735754
11	ribosomal small subunit biogenesis (GO:0042274)	6.01251370
12	cotranslational protein targeting to membrane (GO:0006613)	5.92972811
13	protein targeting to ER (GO:0045047)	5.86270669
14	L-phenylalanine catabolic process (GO:0006559)	5.77843570
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.77843570
16	translational elongation (GO:0006414)	5.67503869
17	virion assembly (GO:0019068)	5.63480036
18	cellular protein complex disassembly (GO:0043624)	5.62496476
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.57016727
20	protein localization to endoplasmic reticulum (GO:0070972)	5.53873620
21	neuron fate determination (GO:0048664)	5.51346650
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.41634062
23	viral life cycle (GO:0019058)	5.38493543
24	protein neddylation (GO:0045116)	5.29784312
25	tyrosine metabolic process (GO:0006570)	5.06686664
26	protein complex disassembly (GO:0043241)	5.05103144
27	acrosome assembly (GO:0001675)	4.88993785
28	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.83300200
29	L-phenylalanine metabolic process (GO:0006558)	4.83300200
30	positive regulation of cell fate commitment (GO:0010455)	4.69930312
31	macromolecular complex disassembly (GO:0032984)	4.69297753
32	male meiosis I (GO:0007141)	4.58406889
33	behavioral response to nicotine (GO:0035095)	4.46004051
34	centriole replication (GO:0007099)	4.43646755
35	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	4.32644832
36	protein targeting to membrane (GO:0006612)	4.30645351
37	ATP synthesis coupled proton transport (GO:0015986)	4.12709931
38	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.12709931
39	translational initiation (GO:0006413)	4.07687662
40	N-glycan processing (GO:0006491)	3.96830494
41	protein targeting to Golgi (GO:0000042)	3.95177730
42	presynaptic membrane assembly (GO:0097105)	3.89585218
43	seminiferous tubule development (GO:0072520)	3.84901188
44	axonemal dynein complex assembly (GO:0070286)	3.82067176
45	hair cell differentiation (GO:0035315)	3.81918754
46	snRNA transcription (GO:0009301)	3.79424407
47	negative regulation of cell fate commitment (GO:0010454)	3.74030717
48	histone H4 deacetylation (GO:0070933)	3.73935462
49	auditory receptor cell differentiation (GO:0042491)	3.72892445
50	establishment of protein localization to Golgi (GO:0072600)	3.71610792
51	positive regulation of protein homooligomerization (GO:0032464)	3.69021898
52	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.68480445
53	regulation of meiosis I (GO:0060631)	3.61003484
54	alditol metabolic process (GO:0019400)	3.59753882
55	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.57927414
56	negative regulation of glial cell differentiation (GO:0045686)	3.56929162
57	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.52619085
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.48276062
59	pattern specification involved in kidney development (GO:0061004)	3.48117703
60	positive regulation of male gonad development (GO:2000020)	3.47618407
61	middle ear morphogenesis (GO:0042474)	3.42928732
62	meiosis I (GO:0007127)	3.42731064
63	protein localization to Golgi apparatus (GO:0034067)	3.42689680
64	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.41627672
65	negative regulation of DNA repair (GO:0045738)	3.40771965
66	monoubiquitinated protein deubiquitination (GO:0035520)	3.31858118
67	mRNA catabolic process (GO:0006402)	3.30046749
68	glycerol metabolic process (GO:0006071)	3.27382449
69	histone deubiquitination (GO:0016578)	3.27081140
70	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.26661755
71	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.26142745
72	chemosensory behavior (GO:0007635)	3.23049388
73	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.20730704
74	presynaptic membrane organization (GO:0097090)	3.18071287
75	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.17709679
76	axoneme assembly (GO:0035082)	3.17319026
77	intermediate filament organization (GO:0045109)	3.16785089
78	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.13994207
79	cellular ketone body metabolic process (GO:0046950)	3.12287577
80	somite rostral/caudal axis specification (GO:0032525)	3.11748740
81	centriole assembly (GO:0098534)	3.10971899
82	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.08828003
83	neuronal stem cell maintenance (GO:0097150)	3.07644897
84	synapsis (GO:0007129)	3.00736775
85	regulation of translational fidelity (GO:0006450)	2.99335730
86	dendritic spine morphogenesis (GO:0060997)	2.98904214
87	negative regulation of JUN kinase activity (GO:0043508)	2.98598896
88	RNA catabolic process (GO:0006401)	2.94207939
89	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.89621204
90	cell proliferation in forebrain (GO:0021846)	2.87183585
91	negative regulation of transcription by competitive promoter binding (GO:0010944)	2.86896795
92	male sex determination (GO:0030238)	2.85972965
93	translation (GO:0006412)	2.85943291
94	ribosomal large subunit biogenesis (GO:0042273)	2.85455254
95	spinal cord development (GO:0021510)	2.81073839
96	positive regulation of gastrulation (GO:2000543)	2.80019036
97	negative regulation of gliogenesis (GO:0014014)	2.79920718
98	male meiosis (GO:0007140)	2.79215930
99	lipid particle organization (GO:0034389)	2.79018938
100	establishment of protein localization to membrane (GO:0090150)	2.78398739

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.44832883
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.76305998
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.48300334
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.24991760
5	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.97931432
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.68545515
7	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.60069954
8	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.36214697
9	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.29938895
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.15061850
11	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.83450814
12	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.80520635
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73293006
14	VDR_22108803_ChIP-Seq_LS180_Human	1.64978786
15	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.57085031
16	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.56737888
17	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.55611275
18	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.51564379
19	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.51014860
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.50996486
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48822415
22	ERG_20517297_ChIP-Seq_VCAP_Human	1.48185925
23	NANOG_20526341_ChIP-Seq_ESCs_Human	1.48077014
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43229254
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.42498942
26	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.39285907
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.38908228
28	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.38344832
29	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.38308525
30	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.38123275
31	ERA_21632823_ChIP-Seq_H3396_Human	1.38027130
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37065176
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.34826679
34	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.34043484
35	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.34043484
36	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.34043484
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.33518383
38	HTT_18923047_ChIP-ChIP_STHdh_Human	1.33166110
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.32223502
40	EGR1_19032775_ChIP-ChIP_M12_Human	1.28986860
41	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.25906908
42	ZNF274_21170338_ChIP-Seq_K562_Hela	1.25565539
43	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.24813200
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.22955581
45	XRN2_22483619_ChIP-Seq_HELA_Human	1.20918711
46	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.20041067
47	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19546700
48	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.19244279
49	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18644861
50	CTCF_27219007_Chip-Seq_Bcells_Human	1.18204597
51	E2F7_22180533_ChIP-Seq_HELA_Human	1.18110997
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17103691
53	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.15441285
54	SOX3_22085726_ChIP-Seq_NPCs_Mouse	1.11299094
55	KDM5A_27292631_Chip-Seq_BREAST_Human	1.10675863
56	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.10217983
57	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.09114743
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09078384
59	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.08936816
60	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.08846303
61	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.06460122
62	* SA1_27219007_Chip-Seq_Bcells_Human	1.04737569
63	BCL6_27268052_Chip-Seq_Bcells_Human	1.04691573
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.04503328
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03383180
66	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.03280594
67	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.01159185
68	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.00823145
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00746188
70	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.99392700
71	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98779408
72	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97454820
73	CIITA_25753668_ChIP-Seq_RAJI_Human	0.97095982
74	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97007821
75	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.96125215
76	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.95208385
77	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.93129745
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.92977946
79	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.91575998
80	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.91411346
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91238082
82	CBP_20019798_ChIP-Seq_JUKART_Human	0.91238082
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90268843
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89289431
85	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.89128351
86	P68_20966046_ChIP-Seq_HELA_Human	0.88319143
87	DCP1A_22483619_ChIP-Seq_HELA_Human	0.87547862
88	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.86909898
89	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86459530
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86459530
91	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.86167739
92	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.85698513
93	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85683853
94	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.85544813
95	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.84841553
96	REST_21632747_ChIP-Seq_MESCs_Mouse	0.83515436
97	PHF8_20622854_ChIP-Seq_HELA_Human	0.83021098
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.82753197
99	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.82753197
100	SMC4_20622854_ChIP-Seq_HELA_Human	0.82201409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.71092586
2	MP0002837_dystrophic_cardiac_calcinosis	5.87224988
3	MP0003878_abnormal_ear_physiology	5.81661196
4	MP0005377_hearing/vestibular/ear_phenot	5.81661196
5	MP0006292_abnormal_olfactory_placode	4.29325201
6	MP0002653_abnormal_ependyma_morphology	3.79590408
7	MP0003136_yellow_coat_color	3.02928022
8	MP0001849_ear_inflammation	2.98249443
9	MP0003890_abnormal_embryonic-extraembry	2.81828740
10	MP0010307_abnormal_tumor_latency	2.79066843
11	MP0001485_abnormal_pinna_reflex	2.66705964
12	MP0000647_abnormal_sebaceous_gland	2.57228886
13	MP0008877_abnormal_DNA_methylation	2.39886188
14	MP0001529_abnormal_vocalization	2.31918302
15	MP0003183_abnormal_peptide_metabolism	2.29694782
16	MP0008789_abnormal_olfactory_epithelium	2.17358156
17	MP0000049_abnormal_middle_ear	2.05382510
18	MP0003646_muscle_fatigue	1.99260914
19	MP0005394_taste/olfaction_phenotype	1.98462163
20	MP0005499_abnormal_olfactory_system	1.98462163
21	MP0010030_abnormal_orbit_morphology	1.96975747
22	MP0002938_white_spotting	1.84873511
23	MP0001293_anophthalmia	1.81923871
24	MP0002095_abnormal_skin_pigmentation	1.81712505
25	MP0000566_synostosis	1.64978718
26	MP0005174_abnormal_tail_pigmentation	1.57800428
27	MP0000427_abnormal_hair_cycle	1.55722767
28	MP0002234_abnormal_pharynx_morphology	1.49754457
29	MP0004270_analgesia	1.41962251
30	MP0005408_hypopigmentation	1.40652948
31	MP0003122_maternal_imprinting	1.38315678
32	MP0001986_abnormal_taste_sensitivity	1.35089599
33	MP0002098_abnormal_vibrissa_morphology	1.34118211
34	MP0002282_abnormal_trachea_morphology	1.32908402
35	MP0000579_abnormal_nail_morphology	1.32736815
36	MP0004381_abnormal_hair_follicle	1.32463481
37	MP0003186_abnormal_redox_activity	1.28286528
38	MP0000013_abnormal_adipose_tissue	1.23322712
39	MP0004019_abnormal_vitamin_homeostasis	1.18552061
40	MP0005075_abnormal_melanosome_morpholog	1.17458650
41	MP0008995_early_reproductive_senescence	1.16505800
42	MP0000377_abnormal_hair_follicle	1.11226576
43	MP0008058_abnormal_DNA_repair	1.02424779
44	MP0001968_abnormal_touch/_nociception	0.98729755
45	MP0003755_abnormal_palate_morphology	0.98572035
46	MP0002102_abnormal_ear_morphology	0.98304135
47	MP0003698_abnormal_male_reproductive	0.96236024
48	MP0002928_abnormal_bile_duct	0.95961334
49	MP0004742_abnormal_vestibular_system	0.94755469
50	MP0001486_abnormal_startle_reflex	0.93888363
51	MP0001963_abnormal_hearing_physiology	0.89926446
52	MP0002092_abnormal_eye_morphology	0.88950653
53	MP0002638_abnormal_pupillary_reflex	0.87466006
54	MP0002163_abnormal_gland_morphology	0.84543008
55	MP0009046_muscle_twitch	0.83955808
56	MP0000778_abnormal_nervous_system	0.82714493
57	MP0002138_abnormal_hepatobiliary_system	0.80430580
58	MP0001929_abnormal_gametogenesis	0.78681575
59	MP0001348_abnormal_lacrimal_gland	0.77788646
60	MP0002210_abnormal_sex_determination	0.76914800
61	MP0002295_abnormal_pulmonary_circulatio	0.75607563
62	MP0003786_premature_aging	0.73768820
63	MP0001545_abnormal_hematopoietic_system	0.72803090
64	MP0005397_hematopoietic_system_phenotyp	0.72803090
65	MP0004885_abnormal_endolymph	0.69640538
66	MP0005379_endocrine/exocrine_gland_phen	0.69341086
67	MP0005386_behavior/neurological_phenoty	0.65242514
68	MP0004924_abnormal_behavior	0.65242514
69	MP0002233_abnormal_nose_morphology	0.64893476
70	MP0006276_abnormal_autonomic_nervous	0.64210089
71	MP0000026_abnormal_inner_ear	0.63566726
72	MP0005647_abnormal_sex_gland	0.62923437
73	MP0002697_abnormal_eye_size	0.62816889
74	MP0001145_abnormal_male_reproductive	0.62731823
75	MP0002152_abnormal_brain_morphology	0.62686593
76	MP0003567_abnormal_fetal_cardiomyocyte	0.62044479
77	MP0005501_abnormal_skin_physiology	0.58674875
78	MP0002161_abnormal_fertility/fecundity	0.58230108
79	MP0002751_abnormal_autonomic_nervous	0.57794747
80	MP0000631_abnormal_neuroendocrine_gland	0.56647431
81	MP0002572_abnormal_emotion/affect_behav	0.55154733
82	MP0005275_abnormal_skin_tensile	0.54929426
83	MP0001324_abnormal_eye_pigmentation	0.54049434
84	MP0003861_abnormal_nervous_system	0.53995583
85	MP0000653_abnormal_sex_gland	0.53262979
86	MP0004133_heterotaxia	0.53192644
87	MP0003011_delayed_dark_adaptation	0.53037214
88	MP0005195_abnormal_posterior_eye	0.52777633
89	MP0000467_abnormal_esophagus_morphology	0.52585418
90	MP0002063_abnormal_learning/memory/cond	0.52328243
91	MP0003635_abnormal_synaptic_transmissio	0.51428998
92	MP0003283_abnormal_digestive_organ	0.49501503
93	MP0003121_genomic_imprinting	0.49368687
94	MP0003936_abnormal_reproductive_system	0.48879574
95	MP0003787_abnormal_imprinting	0.48552196
96	MP0000367_abnormal_coat/_hair	0.47601945
97	MP0005391_vision/eye_phenotype	0.47343715
98	MP0003937_abnormal_limbs/digits/tail_de	0.47058905
99	MP0005084_abnormal_gallbladder_morpholo	0.46030241
100	MP0000955_abnormal_spinal_cord	0.44894845

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	7.63699624
2	Lipid accumulation in hepatocytes (HP:0006561)	7.01796847
3	Increased intramyocellular lipid droplets (HP:0012240)	5.71637266
4	Renal Fanconi syndrome (HP:0001994)	5.64716886
5	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	5.05176735
6	Reticulocytopenia (HP:0001896)	5.04773563
7	Increased muscle lipid content (HP:0009058)	4.97079868
8	Exertional dyspnea (HP:0002875)	4.61278117
9	Chromsome breakage (HP:0040012)	4.30371459
10	Abnormality of DNA repair (HP:0003254)	4.09753012
11	Respiratory difficulties (HP:0002880)	4.09347710
12	Abnormality of cells of the erythroid lineage (HP:0012130)	4.07740219
13	Abdominal situs inversus (HP:0003363)	3.77751385
14	Abnormality of abdominal situs (HP:0011620)	3.77751385
15	Abnormality of renal resorption (HP:0011038)	3.63422905
16	Flat capital femoral epiphysis (HP:0003370)	3.56414294
17	Genetic anticipation (HP:0003743)	3.42639454
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.35240150
19	Mitochondrial inheritance (HP:0001427)	3.34208003
20	Brittle hair (HP:0002299)	3.34082251
21	Abnormal number of erythroid precursors (HP:0012131)	3.32727570
22	Septo-optic dysplasia (HP:0100842)	3.30199868
23	Entropion (HP:0000621)	3.29069992
24	11 pairs of ribs (HP:0000878)	3.12153478
25	Woolly hair (HP:0002224)	3.10521484
26	High anterior hairline (HP:0009890)	3.08117720
27	Pili torti (HP:0003777)	2.98597125
28	Onycholysis (HP:0001806)	2.98247839
29	Pendular nystagmus (HP:0012043)	2.94196095
30	Pancreatic fibrosis (HP:0100732)	2.92696822
31	Increased CSF lactate (HP:0002490)	2.92119879
32	Hyperphosphaturia (HP:0003109)	2.91596919
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.84275449
34	True hermaphroditism (HP:0010459)	2.78348246
35	Macrocytic anemia (HP:0001972)	2.74796963
36	Progressive cerebellar ataxia (HP:0002073)	2.70407157
37	Recurrent cutaneous fungal infections (HP:0011370)	2.69150556
38	Chronic mucocutaneous candidiasis (HP:0002728)	2.69150556
39	Slow-growing hair (HP:0002217)	2.61402866
40	Abnormality of hair growth rate (HP:0011363)	2.61402866
41	Colon cancer (HP:0003003)	2.59424263
42	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.57049182
43	Cystic liver disease (HP:0006706)	2.52033247
44	Fragile nails (HP:0001808)	2.48654663
45	Molar tooth sign on MRI (HP:0002419)	2.47090859
46	Abnormality of midbrain morphology (HP:0002418)	2.47090859
47	Nuclear cataract (HP:0100018)	2.43266151
48	Absent septum pellucidum (HP:0001331)	2.41062378
49	Slow saccadic eye movements (HP:0000514)	2.37956871
50	Missing ribs (HP:0000921)	2.33944986
51	Pallor (HP:0000980)	2.33761039
52	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.33213921
53	Abnormality of urine glucose concentration (HP:0011016)	2.32145184
54	Glycosuria (HP:0003076)	2.32145184
55	Absent thumb (HP:0009777)	2.31580595
56	Pancreatic cysts (HP:0001737)	2.31475917
57	Abnormal urine phosphate concentration (HP:0012599)	2.29245707
58	Sclerocornea (HP:0000647)	2.25384971
59	Panhypogammaglobulinemia (HP:0003139)	2.25185835
60	Poikiloderma (HP:0001029)	2.24484746
61	Acute necrotizing encephalopathy (HP:0006965)	2.23479978
62	Type II lissencephaly (HP:0007260)	2.23024488
63	Broad alveolar ridges (HP:0000187)	2.15253833
64	Long foot (HP:0001833)	2.14939512
65	Anterior segment dysgenesis (HP:0007700)	2.14504283
66	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14459508
67	Nephronophthisis (HP:0000090)	2.13141401
68	Duplicated collecting system (HP:0000081)	2.10989058
69	Testicular atrophy (HP:0000029)	2.02589556
70	Hypotrichosis (HP:0001006)	2.00532928
71	Hepatocellular necrosis (HP:0001404)	2.00319602
72	Maternal diabetes (HP:0009800)	1.99611253
73	Abnormality of the renal medulla (HP:0100957)	1.95542535
74	Hydroureter (HP:0000072)	1.94419768
75	Flared iliac wings (HP:0002869)	1.93911163
76	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93215971
77	Abnormality of the renal collecting system (HP:0004742)	1.91747638
78	Abnormal biliary tract physiology (HP:0012439)	1.91019323
79	Bile duct proliferation (HP:0001408)	1.91019323
80	Abnormality of the ileum (HP:0001549)	1.90719146
81	Congenital ichthyosiform erythroderma (HP:0007431)	1.89495743
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.88526392
83	Ulnar deviation of the wrist (HP:0003049)	1.88428451
84	Abnormality of small intestinal villus morphology (HP:0011472)	1.87772848
85	Villous atrophy (HP:0011473)	1.87772848
86	Asplenia (HP:0001746)	1.85699902
87	Scrotal hypoplasia (HP:0000046)	1.85515191
88	Renal tubular dysfunction (HP:0000124)	1.85268427
89	Erythroderma (HP:0001019)	1.84159685
90	Depressed nasal ridge (HP:0000457)	1.84003750
91	Hepatic necrosis (HP:0002605)	1.83779595
92	Exercise intolerance (HP:0003546)	1.80998098
93	Occipital encephalocele (HP:0002085)	1.80840573
94	Pigmentary retinal degeneration (HP:0001146)	1.79186410
95	Acute encephalopathy (HP:0006846)	1.78234378
96	Abnormality of the preputium (HP:0100587)	1.77699987
97	Cerebellar dysplasia (HP:0007033)	1.77241982
98	Decreased muscle mass (HP:0003199)	1.75721363
99	Increased serum lactate (HP:0002151)	1.74018288
100	Meckel diverticulum (HP:0002245)	1.73254077

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.55907093
2	CDK19	4.20414883
3	EPHB2	4.18067100
4	STK39	3.83121331
5	PAK3	3.27832456
6	PINK1	3.22394924
7	CASK	2.49860958
8	MAPK15	2.34747982
9	OXSR1	2.29933123
10	NTRK1	2.15560034
11	TIE1	2.12036356
12	MYLK	2.10308087
13	STK16	2.09174154
14	MAP3K10	2.03833129
15	DMPK	1.98895558
16	WNK1	1.98531907
17	RPS6KL1	1.74797329
18	RPS6KC1	1.74797329
19	RPS6KA6	1.69266724
20	WNK3	1.67230284
21	DYRK3	1.65507816
22	IRAK1	1.64009425
23	MAP2K3	1.63665298
24	NTRK2	1.53343568
25	MAP2K4	1.52290779
26	RPS6KA4	1.51341744
27	PRKD3	1.40565564
28	LRRK2	1.33463768
29	CAMK4	1.22895302
30	MAP2K6	1.21572350
31	STK4	1.14468271
32	STK11	1.11600125
33	CAMKK2	1.10853326
34	SGK2	1.05821802
35	MAP2K2	1.04690356
36	RIPK1	1.03649961
37	IKBKE	1.00657405
38	MAPK11	0.98674965
39	HIPK2	0.97916854
40	MARK2	0.97142158
41	DYRK1B	0.94370969
42	SGK223	0.93773551
43	SGK494	0.93773551
44	PIM2	0.93567158
45	RPS6KA2	0.92216900
46	CAMK1	0.84766849
47	MAP3K8	0.84541156
48	CAMK2D	0.83853989
49	MAPK7	0.81178815
50	MAP3K7	0.79391727
51	EPHA4	0.79001912
52	TYK2	0.78104037
53	CAMKK1	0.74948028
54	PNCK	0.72073628
55	PIK3CA	0.70450927
56	CAMK1D	0.69924822
57	ROCK2	0.67576105
58	PRKCG	0.64449803
59	MAPK12	0.62861673
60	PRKCQ	0.62350112
61	ABL2	0.58572423
62	CDK4	0.57441912
63	DYRK2	0.56649908
64	CAMK2G	0.56401938
65	CHEK2	0.56068050
66	CSNK1E	0.54576549
67	PRKDC	0.54228701
68	MTOR	0.52946480
69	DAPK3	0.52355307
70	PRKAA2	0.50054926
71	PRKCE	0.49794339
72	STK38L	0.48339076
73	AKT1	0.48308012
74	GRK1	0.47874773
75	PKN1	0.45682769
76	CSNK2A2	0.45043806
77	ERBB4	0.44071179
78	MAP3K4	0.43751390
79	RPS6KA5	0.42729642
80	MET	0.40726509
81	PRKACA	0.40500711
82	RPS6KA1	0.39429314
83	PAK1	0.37719026
84	TNIK	0.37704408
85	SGK1	0.36640039
86	CDK3	0.36307089
87	FLT3	0.34933121
88	VRK2	0.34726441
89	CSNK2A1	0.34165184
90	ADRBK1	0.33892272
91	GSK3A	0.33160752
92	MAPK13	0.32541824
93	PRKCA	0.31907735
94	TEC	0.31498680
95	CAMK2B	0.30633217
96	EPHA3	0.30617695
97	PRKCD	0.30389308
98	MAPK8	0.30161155
99	INSRR	0.29748696
100	STK3	0.29283190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.54017804
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.16710276
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.88682808
4	Protein export_Homo sapiens_hsa03060	2.74242281
5	Tyrosine metabolism_Homo sapiens_hsa00350	2.47262500
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31830467
7	Parkinsons disease_Homo sapiens_hsa05012	2.22476931
8	Butanoate metabolism_Homo sapiens_hsa00650	2.11592484
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.03934356
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.02829907
11	Regulation of autophagy_Homo sapiens_hsa04140	2.01933839
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88627859
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87720166
14	Huntingtons disease_Homo sapiens_hsa05016	1.81403306
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.72684833
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64715340
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.60465733
18	Alzheimers disease_Homo sapiens_hsa05010	1.53283476
19	Notch signaling pathway_Homo sapiens_hsa04330	1.44554820
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.43483952
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.35450413
22	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.29129780
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.27124651
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24095397
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.23820703
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.22952168
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.18682596
28	Propanoate metabolism_Homo sapiens_hsa00640	1.16048892
29	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.15358355
30	Homologous recombination_Homo sapiens_hsa03440	1.08883157
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.06625244
32	mRNA surveillance pathway_Homo sapiens_hsa03015	1.02211558
33	Other glycan degradation_Homo sapiens_hsa00511	1.01146914
34	Arginine and proline metabolism_Homo sapiens_hsa00330	1.00113664
35	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.98081774
36	Fatty acid degradation_Homo sapiens_hsa00071	0.94000469
37	Peroxisome_Homo sapiens_hsa04146	0.92258964
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92133638
39	Choline metabolism in cancer_Homo sapiens_hsa05231	0.87657570
40	Fatty acid metabolism_Homo sapiens_hsa01212	0.84960308
41	Phototransduction_Homo sapiens_hsa04744	0.83776359
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.82830006
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.81684151
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79681750
45	RNA polymerase_Homo sapiens_hsa03020	0.79037880
46	Sulfur relay system_Homo sapiens_hsa04122	0.76999320
47	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76399289
48	Glucagon signaling pathway_Homo sapiens_hsa04922	0.71663089
49	Retinol metabolism_Homo sapiens_hsa00830	0.68957734
50	DNA replication_Homo sapiens_hsa03030	0.62410371
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60358096
52	Hippo signaling pathway_Homo sapiens_hsa04390	0.59134406
53	Olfactory transduction_Homo sapiens_hsa04740	0.58380515
54	Nicotine addiction_Homo sapiens_hsa05033	0.56497734
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55771655
56	Wnt signaling pathway_Homo sapiens_hsa04310	0.55622647
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55451946
58	Axon guidance_Homo sapiens_hsa04360	0.49347526
59	ABC transporters_Homo sapiens_hsa02010	0.49320956
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49150221
61	Metabolic pathways_Homo sapiens_hsa01100	0.49093052
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46299070
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.44933555
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44150942
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43819171
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.43603181
67	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.42591009
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42070949
69	Fatty acid elongation_Homo sapiens_hsa00062	0.40287381
70	Insulin secretion_Homo sapiens_hsa04911	0.39983080
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.39976195
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.38896730
73	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.38811388
74	Melanogenesis_Homo sapiens_hsa04916	0.38407285
75	Spliceosome_Homo sapiens_hsa03040	0.37960636
76	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35504657
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35443204
78	Glutathione metabolism_Homo sapiens_hsa00480	0.35058840
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31743040
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30945421
81	Sulfur metabolism_Homo sapiens_hsa00920	0.30164322
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27565879
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.26816869
84	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.25700796
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25566459
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25051214
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.24978499
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.24300521
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.23675754
90	Insulin resistance_Homo sapiens_hsa04931	0.23014950
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.22991492
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22703641
93	Purine metabolism_Homo sapiens_hsa00230	0.22674575
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.20838147
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.20720525
96	Histidine metabolism_Homo sapiens_hsa00340	0.20096669
97	Amphetamine addiction_Homo sapiens_hsa05031	0.19741968
98	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.19447358
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.17937676
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.17360772

KRTAP5-10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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