ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	molting cycle (GO:0042303)	6.39244585
2	hair cycle (GO:0042633)	6.39244585
3	DNA double-strand break processing (GO:0000729)	5.28348759
4	photoreceptor cell maintenance (GO:0045494)	4.93478115
5	tachykinin receptor signaling pathway (GO:0007217)	4.47937225
6	regulation of hippo signaling (GO:0035330)	4.28658169
7	retinal cone cell development (GO:0046549)	4.14295651
8	signal peptide processing (GO:0006465)	4.01498706
9	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.98599890
10	indole-containing compound catabolic process (GO:0042436)	3.97948836
11	indolalkylamine catabolic process (GO:0046218)	3.97948836
12	tryptophan catabolic process (GO:0006569)	3.97948836
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.96000820
14	neural tube formation (GO:0001841)	3.93995686
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.91910951
16	gamma-aminobutyric acid transport (GO:0015812)	3.84401371
17	DNA integration (GO:0015074)	3.80256411
18	regulation of posttranscriptional gene silencing (GO:0060147)	3.66543163
19	regulation of gene silencing by miRNA (GO:0060964)	3.66543163
20	regulation of gene silencing by RNA (GO:0060966)	3.66543163
21	regulation of glucocorticoid secretion (GO:2000849)	3.57550950
22	indolalkylamine metabolic process (GO:0006586)	3.54275133
23	L-methionine salvage (GO:0071267)	3.48628801
24	L-methionine biosynthetic process (GO:0071265)	3.48628801
25	amino acid salvage (GO:0043102)	3.48628801
26	base-excision repair, AP site formation (GO:0006285)	3.47812206
27	somite rostral/caudal axis specification (GO:0032525)	3.39224891
28	L-fucose catabolic process (GO:0042355)	3.38153431
29	fucose catabolic process (GO:0019317)	3.38153431
30	L-fucose metabolic process (GO:0042354)	3.38153431
31	tryptophan metabolic process (GO:0006568)	3.35450689
32	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.35381270
33	reflex (GO:0060004)	3.35164854
34	positive regulation of mitochondrial fission (GO:0090141)	3.27674392
35	amine catabolic process (GO:0009310)	3.24386051
36	cellular biogenic amine catabolic process (GO:0042402)	3.24386051
37	histone H4-K12 acetylation (GO:0043983)	3.21251186
38	DNA catabolic process, exonucleolytic (GO:0000738)	3.17860453
39	piRNA metabolic process (GO:0034587)	3.11132794
40	transmission of nerve impulse (GO:0019226)	3.00645339
41	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.98492943
42	detection of light stimulus involved in sensory perception (GO:0050962)	2.89477605
43	detection of light stimulus involved in visual perception (GO:0050908)	2.89477605
44	double-strand break repair via homologous recombination (GO:0000724)	2.88651441
45	snRNA transcription (GO:0009301)	2.88374718
46	ubiquinone metabolic process (GO:0006743)	2.87265645
47	recombinational repair (GO:0000725)	2.87071302
48	kynurenine metabolic process (GO:0070189)	2.86272032
49	regulation of corticosteroid hormone secretion (GO:2000846)	2.85428464
50	ubiquinone biosynthetic process (GO:0006744)	2.83217605
51	N-terminal protein amino acid acetylation (GO:0006474)	2.82969646
52	seminiferous tubule development (GO:0072520)	2.79809415
53	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.79288330
54	methionine biosynthetic process (GO:0009086)	2.79043168
55	dopamine transport (GO:0015872)	2.78448601
56	DNA methylation involved in gamete generation (GO:0043046)	2.78244344
57	positive regulation of developmental pigmentation (GO:0048087)	2.77341428
58	behavioral response to ethanol (GO:0048149)	2.76794436
59	protein localization to cilium (GO:0061512)	2.76305127
60	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.76064070
61	sensory perception of smell (GO:0007608)	2.73449950
62	regulation of acrosome reaction (GO:0060046)	2.71072589
63	cilium movement (GO:0003341)	2.68558895
64	dicarboxylic acid catabolic process (GO:0043649)	2.65679759
65	reciprocal DNA recombination (GO:0035825)	2.64402083
66	reciprocal meiotic recombination (GO:0007131)	2.64402083
67	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.62796589
68	negative regulation of neurotransmitter transport (GO:0051589)	2.62712903
69	auditory receptor cell stereocilium organization (GO:0060088)	2.62668879
70	membrane depolarization during action potential (GO:0086010)	2.62499533
71	postsynaptic membrane organization (GO:0001941)	2.62295307
72	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.61897196
73	translesion synthesis (GO:0019985)	2.60776192
74	cilium morphogenesis (GO:0060271)	2.60457165
75	ADP metabolic process (GO:0046031)	2.60290503
76	indole-containing compound metabolic process (GO:0042430)	2.59805295
77	NAD biosynthetic process (GO:0009435)	2.59315528
78	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.56636494
79	axoneme assembly (GO:0035082)	2.56621301
80	acrosome reaction (GO:0007340)	2.56152835
81	intermediate filament organization (GO:0045109)	2.55672126
82	gene silencing by RNA (GO:0031047)	2.55663031
83	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.55511584
84	behavioral response to nicotine (GO:0035095)	2.53002888
85	fatty acid elongation (GO:0030497)	2.52081854
86	anterograde synaptic vesicle transport (GO:0048490)	2.52055937
87	neuronal action potential propagation (GO:0019227)	2.51972827
88	pyrimidine dimer repair (GO:0006290)	2.51286925
89	neuronal action potential (GO:0019228)	2.50564384
90	amino-acid betaine metabolic process (GO:0006577)	2.48723008
91	histone H3-K9 modification (GO:0061647)	2.48722238
92	presynaptic membrane assembly (GO:0097105)	2.47172324
93	quinone biosynthetic process (GO:1901663)	2.45183796
94	aspartate family amino acid catabolic process (GO:0009068)	2.44618933
95	regulation of cofactor metabolic process (GO:0051193)	2.44258265
96	regulation of coenzyme metabolic process (GO:0051196)	2.44258265
97	non-recombinational repair (GO:0000726)	2.43011982
98	double-strand break repair via nonhomologous end joining (GO:0006303)	2.43011982
99	epithelial cilium movement (GO:0003351)	2.41293562
100	regulation of development, heterochronic (GO:0040034)	2.41205739

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	4.64268429
2	GBX2_23144817_ChIP-Seq_PC3_Human	4.19731871
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.00219602
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.76687243
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.36933458
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.18834802
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93688328
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.68934939
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62208875
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59477924
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53356195
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43725101
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.15786637
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.13938914
15	FUS_26573619_Chip-Seq_HEK293_Human	2.09986385
16	EWS_26573619_Chip-Seq_HEK293_Human	2.09540934
17	P300_19829295_ChIP-Seq_ESCs_Human	2.02683027
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.96803059
19	STAT3_23295773_ChIP-Seq_U87_Human	1.96443829
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.79729478
21	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.77049475
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75603946
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.74846721
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74744299
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72094203
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71725051
27	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.68691215
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67570316
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.64940946
30	AR_25329375_ChIP-Seq_VCAP_Human	1.60750349
31	TCF4_23295773_ChIP-Seq_U87_Human	1.55199806
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51078052
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47404583
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43600008
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42706305
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.41761387
37	RUNX2_22187159_ChIP-Seq_PCA_Human	1.39774123
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.39564739
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39048442
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39048442
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.37446313
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.37253499
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.34476975
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34476975
45	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33778402
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32885564
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31962403
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31553199
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31553199
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31156918
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26870426
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26506040
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25535270
54	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.23698241
55	* TCF4_22108803_ChIP-Seq_LS180_Human	1.23534956
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22649763
57	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.22357939
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21214196
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20054199
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.19246615
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16937039
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16937039
63	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15745127
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15130897
65	CDX2_22108803_ChIP-Seq_LS180_Human	1.14314103
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14076823
67	AR_20517297_ChIP-Seq_VCAP_Human	1.13911578
68	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.12915490
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.11984560
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11121586
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08022159
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07684798
73	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.07478785
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07412630
75	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.07233972
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06373255
77	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06252057
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05726453
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.04022559
80	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00878480
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00437143
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.99948925
83	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99287458
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98050427
85	NCOR_22424771_ChIP-Seq_293T_Human	0.97916321
86	DROSHA_22980978_ChIP-Seq_HELA_Human	0.97693409
87	TP53_16413492_ChIP-PET_HCT116_Human	0.96726923
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95818112
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95818019
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94392625
91	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.94027872
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93549087
93	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92912839
94	GATA3_26560356_Chip-Seq_TH2_Human	0.92008320
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90140201
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.90138158
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.89889943
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89769366
99	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.89590055
100	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.87570268

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002736_abnormal_nociception_after	4.96226906
2	MP0001968_abnormal_touch/_nociception	3.88028725
3	MP0008789_abnormal_olfactory_epithelium	2.47347183
4	MP0002735_abnormal_chemical_nociception	2.41251671
5	MP0003880_abnormal_central_pattern	2.40287097
6	MP0009046_muscle_twitch	2.32869632
7	MP0001984_abnormal_olfaction	2.27162424
8	MP0000647_abnormal_sebaceous_gland	2.19816055
9	MP0005551_abnormal_eye_electrophysiolog	2.15272784
10	MP0008058_abnormal_DNA_repair	2.15124315
11	MP0005499_abnormal_olfactory_system	2.13129021
12	MP0005394_taste/olfaction_phenotype	2.13129021
13	MP0003950_abnormal_plasma_membrane	2.05857857
14	MP0001529_abnormal_vocalization	2.02701724
15	MP0010094_abnormal_chromosome_stability	1.95920347
16	MP0008057_abnormal_DNA_replication	1.95645393
17	MP0001986_abnormal_taste_sensitivity	1.94054203
18	MP0003136_yellow_coat_color	1.91163832
19	MP0008877_abnormal_DNA_methylation	1.90046807
20	MP0001501_abnormal_sleep_pattern	1.81890100
21	MP0008004_abnormal_stomach_pH	1.77913536
22	MP0004147_increased_porphyrin_level	1.71482806
23	MP0006276_abnormal_autonomic_nervous	1.71177002
24	MP0002638_abnormal_pupillary_reflex	1.69767921
25	MP0002098_abnormal_vibrissa_morphology	1.67495478
26	MP0005253_abnormal_eye_physiology	1.66176741
27	MP0001485_abnormal_pinna_reflex	1.64092137
28	MP0009745_abnormal_behavioral_response	1.59224557
29	MP0005171_absent_coat_pigmentation	1.59067618
30	MP0003878_abnormal_ear_physiology	1.58604609
31	MP0005377_hearing/vestibular/ear_phenot	1.58604609
32	MP0000579_abnormal_nail_morphology	1.55413995
33	MP0004233_abnormal_muscle_weight	1.51677289
34	MP0003635_abnormal_synaptic_transmissio	1.51165678
35	MP0000427_abnormal_hair_cycle	1.46810437
36	MP0006035_abnormal_mitochondrial_morpho	1.45492342
37	MP0008872_abnormal_physiological_respon	1.44494622
38	MP0001486_abnormal_startle_reflex	1.42135887
39	MP0006072_abnormal_retinal_apoptosis	1.37716093
40	MP0002067_abnormal_sensory_capabilities	1.35883692
41	MP0005645_abnormal_hypothalamus_physiol	1.35415594
42	MP0002272_abnormal_nervous_system	1.32617490
43	MP0009697_abnormal_copulation	1.32345064
44	MP0003698_abnormal_male_reproductive	1.30298577
45	MP0001970_abnormal_pain_threshold	1.30218480
46	MP0005670_abnormal_white_adipose	1.27299961
47	MP0002733_abnormal_thermal_nociception	1.26835670
48	MP0005410_abnormal_fertilization	1.25960424
49	MP0004043_abnormal_pH_regulation	1.25950505
50	MP0002653_abnormal_ependyma_morphology	1.24255879
51	MP0005646_abnormal_pituitary_gland	1.22663292
52	MP0003693_abnormal_embryo_hatching	1.21292171
53	MP0001188_hyperpigmentation	1.15809266
54	MP0002184_abnormal_innervation	1.15338927
55	MP0005423_abnormal_somatic_nervous	1.13690305
56	MP0002572_abnormal_emotion/affect_behav	1.12700690
57	MP0001929_abnormal_gametogenesis	1.12363145
58	MP0006292_abnormal_olfactory_placode	1.10316081
59	MP0002557_abnormal_social/conspecific_i	1.07792780
60	MP0004084_abnormal_cardiac_muscle	1.07352139
61	MP0002064_seizures	1.04939590
62	MP0000631_abnormal_neuroendocrine_gland	1.04662920
63	MP0000383_abnormal_hair_follicle	1.04638310
64	MP0003183_abnormal_peptide_metabolism	1.04111442
65	MP0002249_abnormal_larynx_morphology	1.03602617
66	MP0004134_abnormal_chest_morphology	1.02415576
67	MP0004085_abnormal_heartbeat	1.01646132
68	MP0005647_abnormal_sex_gland	1.01448706
69	MP0004885_abnormal_endolymph	0.99962611
70	MP0000372_irregular_coat_pigmentation	0.99010760
71	MP0003385_abnormal_body_wall	0.98624683
72	MP0000049_abnormal_middle_ear	0.96553177
73	MP0005075_abnormal_melanosome_morpholog	0.96294399
74	MP0004142_abnormal_muscle_tone	0.95875729
75	MP0003890_abnormal_embryonic-extraembry	0.94227236
76	MP0002752_abnormal_somatic_nervous	0.91830264
77	MP0002095_abnormal_skin_pigmentation	0.90159878
78	MP0002210_abnormal_sex_determination	0.87275208
79	MP0002882_abnormal_neuron_morphology	0.86613800
80	MP0001963_abnormal_hearing_physiology	0.86427280
81	MP0005174_abnormal_tail_pigmentation	0.86123254
82	MP0002229_neurodegeneration	0.85683394
83	MP0000653_abnormal_sex_gland	0.85469465
84	MP0010386_abnormal_urinary_bladder	0.84747228
85	MP0002233_abnormal_nose_morphology	0.84095300
86	MP0001145_abnormal_male_reproductive	0.83977220
87	MP0002734_abnormal_mechanical_nocicepti	0.83524645
88	MP0001664_abnormal_digestion	0.81676741
89	MP0000026_abnormal_inner_ear	0.80559678
90	MP0005085_abnormal_gallbladder_physiolo	0.79800529
91	MP0003718_maternal_effect	0.78859419
92	MP0004215_abnormal_myocardial_fiber	0.77458244
93	MP0005275_abnormal_skin_tensile	0.76052570
94	MP0002063_abnormal_learning/memory/cond	0.76039527
95	MP0006054_spinal_hemorrhage	0.74706674
96	MP0002102_abnormal_ear_morphology	0.74416095
97	MP0000955_abnormal_spinal_cord	0.73005431
98	MP0001177_atelectasis	0.72448562
99	MP0008775_abnormal_heart_ventricle	0.72095864
100	MP0004924_abnormal_behavior	0.70789985

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Atonic seizures (HP:0010819)	4.22012340
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.94827893
3	Absent/shortened dynein arms (HP:0200106)	3.94827893
4	Hyperventilation (HP:0002883)	3.70403902
5	Abnormal ciliary motility (HP:0012262)	3.51602632
6	Pili torti (HP:0003777)	3.36305930
7	Pancreatic cysts (HP:0001737)	3.11864254
8	Absent eyebrow (HP:0002223)	3.07740468
9	Medial flaring of the eyebrow (HP:0010747)	3.03831412
10	Gaze-evoked nystagmus (HP:0000640)	3.02971989
11	True hermaphroditism (HP:0010459)	2.98779180
12	Pancreatic fibrosis (HP:0100732)	2.91182450
13	Dialeptic seizures (HP:0011146)	2.88417750
14	Abnormal respiratory motile cilium physiology (HP:0012261)	2.86355085
15	Abnormal respiratory epithelium morphology (HP:0012253)	2.85538363
16	Abnormal respiratory motile cilium morphology (HP:0005938)	2.85538363
17	Gait imbalance (HP:0002141)	2.80613042
18	Abnormality of hair growth rate (HP:0011363)	2.78505374
19	Slow-growing hair (HP:0002217)	2.78505374
20	Retinal dysplasia (HP:0007973)	2.75728410
21	Inability to walk (HP:0002540)	2.73935202
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.72881383
23	Abolished electroretinogram (ERG) (HP:0000550)	2.70673063
24	Central scotoma (HP:0000603)	2.70452764
25	Absence seizures (HP:0002121)	2.69495723
26	Congenital primary aphakia (HP:0007707)	2.69341598
27	Congenital stationary night blindness (HP:0007642)	2.66457250
28	Chronic hepatic failure (HP:0100626)	2.59527214
29	Absent eyelashes (HP:0000561)	2.59401358
30	Focal seizures (HP:0007359)	2.58233015
31	Focal motor seizures (HP:0011153)	2.57668424
32	Abnormality of midbrain morphology (HP:0002418)	2.55395047
33	Molar tooth sign on MRI (HP:0002419)	2.55395047
34	Attenuation of retinal blood vessels (HP:0007843)	2.53941112
35	Progressive cerebellar ataxia (HP:0002073)	2.49778688
36	Genital tract atresia (HP:0001827)	2.43088227
37	Cystic liver disease (HP:0006706)	2.42685845
38	Protruding tongue (HP:0010808)	2.41570925
39	Progressive inability to walk (HP:0002505)	2.41158637
40	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.40330688
41	Bony spicule pigmentary retinopathy (HP:0007737)	2.37993378
42	Vaginal atresia (HP:0000148)	2.37945180
43	Tented upper lip vermilion (HP:0010804)	2.36194891
44	Absent speech (HP:0001344)	2.34067006
45	Nephrogenic diabetes insipidus (HP:0009806)	2.33878391
46	Broad alveolar ridges (HP:0000187)	2.33341948
47	Febrile seizures (HP:0002373)	2.31089646
48	Thyroid-stimulating hormone excess (HP:0002925)	2.30839817
49	Bifid tongue (HP:0010297)	2.26486502
50	Brittle hair (HP:0002299)	2.23029610
51	Nephronophthisis (HP:0000090)	2.21039848
52	Abnormality of lateral ventricle (HP:0030047)	2.15300026
53	Drooling (HP:0002307)	2.11890930
54	Gonadotropin excess (HP:0000837)	2.09896042
55	Sclerocornea (HP:0000647)	2.09146928
56	Abnormality of alanine metabolism (HP:0010916)	2.07690511
57	Hyperalaninemia (HP:0003348)	2.07690511
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07690511
59	Poikiloderma (HP:0001029)	2.07674566
60	Clumsiness (HP:0002312)	2.07321699
61	Congenital sensorineural hearing impairment (HP:0008527)	2.07276212
62	Abnormality of macular pigmentation (HP:0008002)	2.04021496
63	Growth hormone deficiency (HP:0000824)	2.02478121
64	Hyperglycinuria (HP:0003108)	2.01734529
65	Fair hair (HP:0002286)	2.00481730
66	Abnormality of the renal medulla (HP:0100957)	2.00189420
67	Type II lissencephaly (HP:0007260)	1.98904167
68	Epileptic encephalopathy (HP:0200134)	1.98473541
69	Widely spaced teeth (HP:0000687)	1.95976709
70	Ileus (HP:0002595)	1.92942068
71	Abnormal hair laboratory examination (HP:0003328)	1.92722271
72	Abnormality of the renal cortex (HP:0011035)	1.90219742
73	Postaxial foot polydactyly (HP:0001830)	1.87959850
74	Stomach cancer (HP:0012126)	1.86794559
75	Abnormality of the labia minora (HP:0012880)	1.86615612
76	Excessive salivation (HP:0003781)	1.86299545
77	Split foot (HP:0001839)	1.85116248
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84301174
79	Poor coordination (HP:0002370)	1.82242259
80	Abnormality of the pubic bones (HP:0003172)	1.81478857
81	Astigmatism (HP:0000483)	1.81029714
82	Absent hair (HP:0002298)	1.80787246
83	Broad foot (HP:0001769)	1.80186246
84	Abnormality of chromosome stability (HP:0003220)	1.80037976
85	Septate vagina (HP:0001153)	1.77255464
86	Retinitis pigmentosa (HP:0000510)	1.77169913
87	Cerebellar dysplasia (HP:0007033)	1.76583139
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.75904955
89	Scotoma (HP:0000575)	1.74852930
90	Broad-based gait (HP:0002136)	1.73957574
91	Action tremor (HP:0002345)	1.73015947
92	Hemiparesis (HP:0001269)	1.72861767
93	Abnormal auditory evoked potentials (HP:0006958)	1.72650781
94	Colon cancer (HP:0003003)	1.71356730
95	Hemiplegia (HP:0002301)	1.71012117
96	Onycholysis (HP:0001806)	1.70271208
97	Intestinal atresia (HP:0011100)	1.68031681
98	Pachygyria (HP:0001302)	1.66695772
99	Micropenis (HP:0000054)	1.66569525
100	Sloping forehead (HP:0000340)	1.65995921

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.03429896
2	MAP3K4	3.14459747
3	MAP2K7	2.85628971
4	TRIM28	2.79978760
5	CDK19	2.62939216
6	AKT3	2.54557845
7	CASK	2.45638613
8	STK38L	2.45194604
9	CCNB1	2.39773145
10	EPHA3	2.29117520
11	INSRR	2.17319518
12	PINK1	2.03407207
13	TEC	2.01507933
14	NUAK1	2.00753434
15	LATS1	1.95743229
16	MAPK13	1.93834690
17	WNK3	1.89751047
18	EIF2AK3	1.58711024
19	ERBB4	1.52173339
20	PBK	1.43653914
21	GRK5	1.40774735
22	MAP3K6	1.38226728
23	TNIK	1.37253129
24	ADRBK2	1.36027236
25	NTRK3	1.34130379
26	MAP4K2	1.33523565
27	MARK1	1.33286676
28	BMPR1B	1.30566623
29	MAP2K4	1.30497100
30	MAP3K13	1.29068414
31	ZAK	1.24466118
32	IRAK1	1.22045352
33	PKN1	1.21849049
34	RPS6KA4	1.20566692
35	ARAF	1.18524977
36	SIK2	1.15384173
37	BRAF	1.14757089
38	MAPKAPK3	1.09368144
39	BCKDK	1.08361169
40	EPHA4	1.05777813
41	ICK	0.97953576
42	CSNK1G3	0.93756187
43	PTK2B	0.87852607
44	TNK2	0.87395081
45	ADRBK1	0.85773198
46	PRKCG	0.83946806
47	PLK2	0.81484414
48	CSNK1A1L	0.80764941
49	STK3	0.79457388
50	FLT3	0.76732608
51	CSNK1G2	0.75778402
52	NTRK2	0.75539720
53	ITK	0.75374034
54	PRKCE	0.75112844
55	GRK1	0.74976567
56	FER	0.74013798
57	CDK3	0.70951834
58	DYRK2	0.70603454
59	PNCK	0.70533912
60	BCR	0.69479672
61	CHEK2	0.68669674
62	PLK4	0.68369566
63	BTK	0.66725285
64	TTK	0.64936848
65	EPHB1	0.64768600
66	CSNK1G1	0.63299224
67	OXSR1	0.63076840
68	MKNK2	0.62935321
69	ATR	0.62197563
70	MST4	0.59268185
71	BRD4	0.58485316
72	NEK6	0.57989728
73	PIK3CG	0.54916886
74	RAF1	0.54830504
75	PRKCQ	0.54586591
76	CDC7	0.52988199
77	ATM	0.51583337
78	STK16	0.51237148
79	TIE1	0.51125006
80	CAMK1	0.50347798
81	PRKCB	0.48961486
82	STK39	0.47831662
83	RPS6KB1	0.47641916
84	STK38	0.47160517
85	MAP2K6	0.46480671
86	MKNK1	0.42767628
87	MAP3K7	0.42559485
88	MAP3K14	0.41466314
89	DYRK3	0.40046217
90	CSNK1D	0.36059852
91	MINK1	0.31247492
92	PRKAA1	0.30991762
93	SYK	0.30942069
94	CDK5	0.30594423
95	CAMK2A	0.29984441
96	PIK3CA	0.29787807
97	RET	0.27704764
98	KIT	0.27421557
99	MARK3	0.27208138
100	OBSCN	0.27171079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.43199352
2	Phototransduction_Homo sapiens_hsa04744	2.78444686
3	Butanoate metabolism_Homo sapiens_hsa00650	2.71581045
4	Nicotine addiction_Homo sapiens_hsa05033	2.64659088
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.54329501
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.51380008
7	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.37132547
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.30683035
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.26851254
10	Olfactory transduction_Homo sapiens_hsa04740	2.21461150
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.05935315
12	beta-Alanine metabolism_Homo sapiens_hsa00410	2.03621053
13	Propanoate metabolism_Homo sapiens_hsa00640	1.94371838
14	GABAergic synapse_Homo sapiens_hsa04727	1.94058554
15	ABC transporters_Homo sapiens_hsa02010	1.90545443
16	Homologous recombination_Homo sapiens_hsa03440	1.88147281
17	Morphine addiction_Homo sapiens_hsa05032	1.84866359
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.72189643
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.71843428
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55027360
21	Circadian entrainment_Homo sapiens_hsa04713	1.53449973
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47978872
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45374072
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44672590
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.40709511
26	Retinol metabolism_Homo sapiens_hsa00830	1.40610099
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.40221224
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.40002239
29	Base excision repair_Homo sapiens_hsa03410	1.39732568
30	Peroxisome_Homo sapiens_hsa04146	1.36858159
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.33743866
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31270346
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.29638116
34	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.28006388
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.27604211
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25882806
37	Salivary secretion_Homo sapiens_hsa04970	1.25854740
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25784552
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.25784148
40	One carbon pool by folate_Homo sapiens_hsa00670	1.25237929
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23139440
42	Fatty acid elongation_Homo sapiens_hsa00062	1.19758343
43	Glycerolipid metabolism_Homo sapiens_hsa00561	1.17234941
44	Taste transduction_Homo sapiens_hsa04742	1.16378019
45	Serotonergic synapse_Homo sapiens_hsa04726	1.16281173
46	Glutamatergic synapse_Homo sapiens_hsa04724	1.14068917
47	Basal transcription factors_Homo sapiens_hsa03022	1.13241147
48	Circadian rhythm_Homo sapiens_hsa04710	1.08169840
49	Long-term depression_Homo sapiens_hsa04730	1.07372160
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06739890
51	Fatty acid degradation_Homo sapiens_hsa00071	1.05019665
52	Ether lipid metabolism_Homo sapiens_hsa00565	1.03068834
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99787996
54	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99141155
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.97670768
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.96243146
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92815968
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.91553867
59	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90486664
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.88113535
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.87715604
62	Glutathione metabolism_Homo sapiens_hsa00480	0.85515610
63	RNA polymerase_Homo sapiens_hsa03020	0.81088273
64	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79922457
65	Regulation of autophagy_Homo sapiens_hsa04140	0.79812818
66	Purine metabolism_Homo sapiens_hsa00230	0.74568811
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73959094
68	Mismatch repair_Homo sapiens_hsa03430	0.71369195
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.71223660
70	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70727568
71	Gastric acid secretion_Homo sapiens_hsa04971	0.70006800
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.68684830
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66405490
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65220776
75	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64895390
76	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.60705338
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.59272818
78	Lysine degradation_Homo sapiens_hsa00310	0.58982639
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58077260
80	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.56872382
81	Metabolic pathways_Homo sapiens_hsa01100	0.54260959
82	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48270458
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.48216133
84	Platelet activation_Homo sapiens_hsa04611	0.48002227
85	RNA transport_Homo sapiens_hsa03013	0.45176355
86	Caffeine metabolism_Homo sapiens_hsa00232	0.44028806
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43418122
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43275436
89	DNA replication_Homo sapiens_hsa03030	0.43175666
90	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39822433
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.39556237
92	Oocyte meiosis_Homo sapiens_hsa04114	0.38883016
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.36351622
94	Histidine metabolism_Homo sapiens_hsa00340	0.34549594
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.34172119
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.33342301
97	Cholinergic synapse_Homo sapiens_hsa04725	0.32460226
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.32279050
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.28837836
100	Melanoma_Homo sapiens_hsa05218	0.27191968

KRTAP5-11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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