KRTAP5-4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.76817808
2virion attachment to host cell (GO:0019062)9.76817808
3desmosome organization (GO:0002934)9.60161279
4citrulline biosynthetic process (GO:0019240)8.86313189
5hair follicle morphogenesis (GO:0031069)8.26743755
6adhesion of symbiont to host (GO:0044406)8.23982611
7peptide cross-linking (GO:0018149)8.00396529
8intermediate filament cytoskeleton organization (GO:0045104)6.43191282
9sulfation (GO:0051923)6.34694916
10intermediate filament-based process (GO:0045103)6.22331801
11cell wall macromolecule metabolic process (GO:0044036)6.19693100
12cell wall macromolecule catabolic process (GO:0016998)6.19693100
13epidermis development (GO:0008544)6.03442975
14citrulline metabolic process (GO:0000052)5.89683393
15keratinocyte differentiation (GO:0030216)5.61608511
16behavioral response to nicotine (GO:0035095)5.41066673
17hair cycle process (GO:0022405)5.40846754
18molting cycle process (GO:0022404)5.40846754
19regulation of glomerulus development (GO:0090192)5.16623260
20establishment of skin barrier (GO:0061436)5.09071227
21cellular response to ATP (GO:0071318)5.08567102
22bundle of His cell to Purkinje myocyte communication (GO:0086069)5.06637504
23positive regulation of fatty acid oxidation (GO:0046321)4.97830854
24regulation of sequestering of triglyceride (GO:0010889)4.85910251
25epidermal cell differentiation (GO:0009913)4.83821192
26peptidyl-arginine modification (GO:0018195)4.83033845
27water-soluble vitamin biosynthetic process (GO:0042364)4.70746266
28cell proliferation in forebrain (GO:0021846)4.70099369
293-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.64201947
30purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.64201947
31skin morphogenesis (GO:0043589)4.62217222
32hemidesmosome assembly (GO:0031581)4.54926475
33regulation of water loss via skin (GO:0033561)4.51712232
34regulation of cell proliferation involved in kidney development (GO:1901722)4.36443418
35otic vesicle formation (GO:0030916)4.09716684
36hair cycle (GO:0042633)34.4762834
37molting cycle (GO:0042303)34.4762834
38negative regulation of telomerase activity (GO:0051974)3.95585046
39regulation of gene silencing by RNA (GO:0060966)3.95411382
40regulation of posttranscriptional gene silencing (GO:0060147)3.95411382
41regulation of gene silencing by miRNA (GO:0060964)3.95411382
42lateral sprouting from an epithelium (GO:0060601)3.94920552
43auditory receptor cell differentiation (GO:0042491)3.93964371
44positive regulation of cAMP-mediated signaling (GO:0043950)3.92575096
45regulation of collateral sprouting (GO:0048670)3.91721065
46keratinocyte development (GO:0003334)3.90281366
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.89788097
48NADH dehydrogenase complex assembly (GO:0010257)3.89788097
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89788097
50somite development (GO:0061053)3.85622309
51tooth mineralization (GO:0034505)3.84969445
52peristalsis (GO:0030432)3.69293786
53phosphatidylinositol acyl-chain remodeling (GO:0036149)3.67400088
54pharyngeal system development (GO:0060037)3.62759500
55kynurenine metabolic process (GO:0070189)3.61129305
56cellular response to lithium ion (GO:0071285)3.60942046
57negative regulation of keratinocyte proliferation (GO:0010839)3.59800318
58gamma-aminobutyric acid transport (GO:0015812)3.59734523
59viral transcription (GO:0019083)3.59687177
60negative regulation of systemic arterial blood pressure (GO:0003085)3.57692084
61negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.57223787
62regulation of keratinocyte differentiation (GO:0045616)3.55988580
63white fat cell differentiation (GO:0050872)3.55610572
64negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.51702058
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.49842065
66tryptophan catabolic process (GO:0006569)3.47037659
67indole-containing compound catabolic process (GO:0042436)3.47037659
68indolalkylamine catabolic process (GO:0046218)3.47037659
69regulation of hippo signaling (GO:0035330)3.45702659
70negative regulation of cardiac muscle tissue development (GO:0055026)3.41490083
71phosphatidylserine acyl-chain remodeling (GO:0036150)3.38862513
72protein complex biogenesis (GO:0070271)3.33336582
73flavonoid metabolic process (GO:0009812)3.30706391
74cellular anion homeostasis (GO:0030002)3.28906263
75hair follicle development (GO:0001942)3.28306060
76positive regulation of metanephros development (GO:0072216)3.24368894
77negative regulation of mast cell activation (GO:0033004)3.23048101
78lung morphogenesis (GO:0060425)3.22929676
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.19194883
80response to lipoprotein particle (GO:0055094)3.17895895
81positive regulation of oligodendrocyte differentiation (GO:0048714)3.14586710
82positive regulation of hair follicle development (GO:0051798)3.14137796
83positive regulation of hair cycle (GO:0042635)3.14137796
84phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.12849284
85regulation of phospholipid biosynthetic process (GO:0071071)3.11724978
86protein polyglutamylation (GO:0018095)3.11120129
87multicellular organismal water homeostasis (GO:0050891)3.04338217
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03334283
89positive regulation of epidermis development (GO:0045684)3.03107420
90translational termination (GO:0006415)3.01979149
91regulation of cholesterol storage (GO:0010885)2.99653418
92protein prenylation (GO:0018342)2.98870951
93prenylation (GO:0097354)2.98870951
94tryptophan metabolic process (GO:0006568)2.98488842
95regulation of hair follicle development (GO:0051797)2.97334015
96indolalkylamine metabolic process (GO:0006586)2.93023782
97negative regulation of hormone biosynthetic process (GO:0032353)2.92934290
98bone trabecula formation (GO:0060346)2.92406240
99epithelium development (GO:0060429)2.88710677
100interkinetic nuclear migration (GO:0022027)2.88422410
101branching involved in labyrinthine layer morphogenesis (GO:0060670)2.88223774
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.87975716
103serotonin metabolic process (GO:0042428)2.87418516
104mitochondrial respiratory chain complex assembly (GO:0033108)2.87138440
105positive regulation of glomerulus development (GO:0090193)2.85943098
106gap junction assembly (GO:0016264)2.82940521
107negative regulation of protein localization to plasma membrane (GO:1903077)2.82374767
108positive regulation of epidermal cell differentiation (GO:0045606)2.82081262
109indole-containing compound metabolic process (GO:0042430)2.81231939
110GPI anchor metabolic process (GO:0006505)2.80144536
111ectoderm development (GO:0007398)2.78082100
112negative regulation of astrocyte differentiation (GO:0048712)2.77945386
113serine family amino acid catabolic process (GO:0009071)2.77490276
114regulation of neurotransmitter uptake (GO:0051580)2.76498191
115regulation of hair cycle (GO:0042634)2.76033865
116N-acetylglucosamine metabolic process (GO:0006044)2.75110064
117regulation of telomerase activity (GO:0051972)2.75090195
118negative regulation of cell cycle arrest (GO:0071157)2.75013584
119regulation of receptor binding (GO:1900120)2.74490907
120negative regulation of appetite (GO:0032099)2.73853957
121negative regulation of response to food (GO:0032096)2.73853957
122ATP synthesis coupled proton transport (GO:0015986)2.72056899
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72056899
124presynaptic membrane assembly (GO:0097105)2.72029950
125negative regulation of heart growth (GO:0061117)2.71580676
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.71580676
127neuromuscular process controlling posture (GO:0050884)2.71284097
128positive regulation of digestive system process (GO:0060456)2.69268025
129regulation of female receptivity (GO:0045924)2.68627107
130lymphangiogenesis (GO:0001946)2.66787562
131primary amino compound metabolic process (GO:1901160)2.66253248
132spindle assembly involved in mitosis (GO:0090307)2.66114677
133regulation of epidermal cell differentiation (GO:0045604)2.65382430
134forebrain morphogenesis (GO:0048853)2.65097605
135positive regulation of meiotic cell cycle (GO:0051446)2.64877035
136positive regulation of triglyceride biosynthetic process (GO:0010867)2.64736856
137negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64624316
138prostate gland growth (GO:0060736)2.64456526
139neuronal action potential (GO:0019228)2.64170482
140regulation of mesenchymal cell apoptotic process (GO:2001053)2.63981452
141negative regulation of DNA biosynthetic process (GO:2000279)2.63721853
142pituitary gland development (GO:0021983)2.63651214
143postsynaptic membrane organization (GO:0001941)2.63422020
144fatty acid elongation (GO:0030497)2.62355120
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60924114
146atrioventricular valve morphogenesis (GO:0003181)2.59776540
147regulation of germinal center formation (GO:0002634)2.59633230
148glandular epithelial cell differentiation (GO:0002067)2.57160858
149hair cell differentiation (GO:0035315)2.57139094
150phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.54209808
151regulation of epidermis development (GO:0045682)2.50745707
152phosphatidylserine metabolic process (GO:0006658)2.50509260
153water homeostasis (GO:0030104)2.46705054
154epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.40432728
155inner ear receptor cell development (GO:0060119)2.38058566
156phosphatidylcholine acyl-chain remodeling (GO:0036151)2.26747801
157post-embryonic morphogenesis (GO:0009886)2.24132914
158ventricular cardiac muscle cell action potential (GO:0086005)2.23675800
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.22123965
160lymph vessel development (GO:0001945)2.19070962
161inner ear receptor cell differentiation (GO:0060113)2.17072137
162negative regulation of cell fate specification (GO:0009996)2.16581392
163cell surface receptor signaling pathway involved in heart development (GO:0061311)2.10586313
164wound healing, spreading of epidermal cells (GO:0035313)2.09231884
165skin development (GO:0043588)2.08289214
166cranial suture morphogenesis (GO:0060363)2.05882476
167regulation of keratinocyte proliferation (GO:0010837)2.03274421
168positive regulation of keratinocyte differentiation (GO:0045618)2.02753706
169regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.02655283
170eyelid development in camera-type eye (GO:0061029)2.01159746
171intermediate filament organization (GO:0045109)11.9514291
172keratinization (GO:0031424)10.6514089
173aging (GO:0007568)1.97986199
174epithelial cell-cell adhesion (GO:0090136)1.97477030
175positive regulation of monocyte chemotaxis (GO:0090026)1.93986405
176negative regulation of epidermis development (GO:0045683)1.92585886
177myotube differentiation (GO:0014902)1.92578055
178cytoskeletal anchoring at plasma membrane (GO:0007016)1.91611472
179regulation of cardioblast differentiation (GO:0051890)1.91246819
180cell communication involved in cardiac conduction (GO:0086065)1.89668129
181outflow tract septum morphogenesis (GO:0003148)1.89111254
182regulation of ruffle assembly (GO:1900027)1.86240554
183alditol phosphate metabolic process (GO:0052646)1.85944281
184non-canonical Wnt signaling pathway (GO:0035567)1.85905883
185regulation of heart rate by cardiac conduction (GO:0086091)1.84527068
186regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.81165309
187regulation of secondary heart field cardioblast proliferation (GO:0003266)1.78645753
188regulation of cardioblast proliferation (GO:0003264)1.78645753
189ephrin receptor signaling pathway (GO:0048013)1.77552695
190cardiac right ventricle morphogenesis (GO:0003215)1.76508148
191negative regulation of mesenchymal cell apoptotic process (GO:2001054)1.72100675
192cranial nerve morphogenesis (GO:0021602)1.71489603
193establishment of tissue polarity (GO:0007164)1.69742165
194establishment of planar polarity (GO:0001736)1.69742165
195cell-substrate junction assembly (GO:0007044)1.69731773
196cochlea morphogenesis (GO:0090103)1.69263135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.89277797
2EZH2_22144423_ChIP-Seq_EOC_Human4.78543884
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.50820716
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.51574996
5P63_26484246_Chip-Seq_KERATINOCYTES_Human3.37955310
6GBX2_23144817_ChIP-Seq_PC3_Human3.30283565
7ZNF274_21170338_ChIP-Seq_K562_Hela3.04289763
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65095776
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.51778530
10FUS_26573619_Chip-Seq_HEK293_Human2.33433543
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22906405
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22750246
13CTCF_20526341_ChIP-Seq_ESCs_Human2.20914252
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19952363
15VDR_22108803_ChIP-Seq_LS180_Human2.18789964
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11943835
17BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.11732005
18NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.11643806
19IGF1R_20145208_ChIP-Seq_DFB_Human2.10939612
20EWS_26573619_Chip-Seq_HEK293_Human2.10770375
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07716589
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02531477
23TP63_17297297_ChIP-ChIP_HaCaT_Human11.4756601
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92727844
25E2F1_20622854_ChIP-Seq_HELA_Human1.89423657
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89192042
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84367271
28EGR1_19032775_ChIP-ChIP_M12_Human1.77684267
29CSB_26484114_Chip-Seq_FIBROBLAST_Human1.76900224
30TAF2_19829295_ChIP-Seq_ESCs_Human1.74402350
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74224887
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.72918305
33NANOG_20526341_ChIP-Seq_ESCs_Human1.72485074
34P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.70917268
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.70208097
36CTCF_27219007_Chip-Seq_Bcells_Human1.69728679
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.69723526
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68762399
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.67940290
40ER_23166858_ChIP-Seq_MCF-7_Human1.64011267
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61234078
42MYC_18940864_ChIP-ChIP_HL60_Human1.60142569
43MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.59566954
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58834450
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.58475224
46P53_21459846_ChIP-Seq_SAOS-2_Human1.58400878
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55503283
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54263264
49IRF1_19129219_ChIP-ChIP_H3396_Human1.53066207
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50868466
51RNF2_27304074_Chip-Seq_NSC_Mouse1.50289688
52ERG_20517297_ChIP-Seq_VCAP_Human1.49752094
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48086110
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46301092
55LXR_22292898_ChIP-Seq_THP-1_Human1.45138565
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44321242
57TP63_22573176_ChIP-Seq_HFKS_Human1.44312777
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.43022218
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42769154
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42569710
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.41162405
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39915564
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.39698969
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39231011
65RACK7_27058665_Chip-Seq_MCF-7_Human1.38707741
66BCL6_27268052_Chip-Seq_Bcells_Human1.38470497
67REST_21632747_ChIP-Seq_MESCs_Mouse1.37492922
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.36837136
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36350251
70CBP_20019798_ChIP-Seq_JUKART_Human1.36350251
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36159270
72BCAT_22108803_ChIP-Seq_LS180_Human1.34575752
73ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33937335
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32621206
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32621206
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31683093
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30915330
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.30419124
79P300_19829295_ChIP-Seq_ESCs_Human1.29479127
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29357793
81SMAD4_21799915_ChIP-Seq_A2780_Human1.29269347
82AHR_22903824_ChIP-Seq_MCF-7_Human1.27431331
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26450127
84BCOR_27268052_Chip-Seq_Bcells_Human1.25263929
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23008862
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.21571102
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.20522288
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19894056
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18342696
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.17786823
91EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17744094
92RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17744094
93TP53_16413492_ChIP-PET_HCT116_Human1.16862487
94AR_21572438_ChIP-Seq_LNCaP_Human1.16792778
95P68_20966046_ChIP-Seq_HELA_Human1.15239674
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.15003759
97MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14168132
98PHF8_20622854_ChIP-Seq_HELA_Human1.13916441
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13698216
100ATF3_27146783_Chip-Seq_COLON_Human1.12097969
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11969195
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11885497
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.11223592
104E2F1_17053090_ChIP-ChIP_MCF-7_Human1.10794378
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.10646888
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09567386
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.07009277
108RAC3_21632823_ChIP-Seq_H3396_Human1.06971304
109FLI1_27457419_Chip-Seq_LIVER_Mouse1.06735965
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.06297701
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05980245
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05488160
113SMC4_20622854_ChIP-Seq_HELA_Human1.04659220
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04630187
115GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04167447
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04054428
117TP53_18474530_ChIP-ChIP_U2OS_Human1.03927130
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03870461
119CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03782808
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03577015
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03012011
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02875882
123CEBPB_22108803_ChIP-Seq_LS180_Human1.02840876
124TP63_23658742_ChIP-Seq_EP156T_Human1.02559455
125TP63_19390658_ChIP-ChIP_HaCaT_Human1.01972724
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01509540
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.01509540
128TAF15_26573619_Chip-Seq_HEK293_Human1.01491945
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.01058599
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00415032
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.98812432
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98583839
133TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98393885
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97807044
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97070219
136GATA6_21074721_ChIP-Seq_CACO-2_Human0.95911696
137GATA4_25053715_ChIP-Seq_YYC3_Human0.95813290
138GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95461220
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.95039311
140SOX2_21211035_ChIP-Seq_LN229_Human0.94810932
141JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94734384
142PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94167202
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94062623
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.93859008
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.93851066
146RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93558264
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93171868
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93151986
149JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93040438
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92947687
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.92486571
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92283648
153POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92091645
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92051775
155FOXH1_21741376_ChIP-Seq_ESCs_Human0.91908774
156TCF4_23295773_ChIP-Seq_U87_Human0.91835589
157RXR_22108803_ChIP-Seq_LS180_Human0.90813361
158KLF5_25053715_ChIP-Seq_YYC3_Human0.90060405
159ERG_21242973_ChIP-ChIP_JURKAT_Human0.90004295
160UBF1/2_26484160_Chip-Seq_HMECs_Human0.89598433
161SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89539961
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.89459174
163JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89284562
164NANOG_16153702_ChIP-ChIP_HESCs_Human0.89145830
165EED_16625203_ChIP-ChIP_MESCs_Mouse0.89033810
166SPI1_20517297_ChIP-Seq_HL60_Human0.88996074
167SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88393424
168EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88171103
169FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88145559
170AR_25329375_ChIP-Seq_VCAP_Human0.88082322
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87728440
172P53_22387025_ChIP-Seq_ESCs_Mouse0.87725869
173* RUNX2_22187159_ChIP-Seq_PCA_Human0.87358155
174STAT3_23295773_ChIP-Seq_U87_Human0.85725690
175KDM2B_26808549_Chip-Seq_REH_Human0.85424790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.56244265
2MP0002098_abnormal_vibrissa_morphology7.42100515
3MP0000647_abnormal_sebaceous_gland6.68943495
4MP0002796_impaired_skin_barrier5.76791566
5MP0005275_abnormal_skin_tensile4.91617846
6MP0010234_abnormal_vibrissa_follicle4.89454218
7MP0000383_abnormal_hair_follicle4.79691494
8MP0010678_abnormal_skin_adnexa4.18328128
9MP0000377_abnormal_hair_follicle4.09483991
10MP0005670_abnormal_white_adipose4.02552317
11MP0005501_abnormal_skin_physiology3.62732012
12MP0003705_abnormal_hypodermis_morpholog3.59284020
13MP0000427_abnormal_hair_cycle3.48382571
14MP0005646_abnormal_pituitary_gland3.30590003
15MP0000569_abnormal_digit_pigmentation3.10186165
16MP0002254_reproductive_system_inflammat2.90983238
17MP0003724_increased_susceptibility_to2.73351672
18MP0001485_abnormal_pinna_reflex2.70805622
19MP0001216_abnormal_epidermal_layer2.59959164
20MP0004381_abnormal_hair_follicle2.55675743
21MP0006292_abnormal_olfactory_placode2.53441038
22MP0002138_abnormal_hepatobiliary_system2.42435990
23MP0002163_abnormal_gland_morphology2.37902134
24MP0000367_abnormal_coat/_hair2.35244117
25MP0010771_integument_phenotype2.29589901
26MP0004145_abnormal_muscle_electrophysio2.28276961
27MP0002234_abnormal_pharynx_morphology2.18809207
28MP0004947_skin_inflammation2.18223878
29MP0004130_abnormal_muscle_cell2.17909499
30MP0000631_abnormal_neuroendocrine_gland2.16694005
31MP0003453_abnormal_keratinocyte_physiol2.14289824
32MP0003646_muscle_fatigue2.10912354
33MP0002060_abnormal_skin_morphology2.10527689
34MP0002938_white_spotting2.04266462
35MP0001243_abnormal_dermal_layer2.02212338
36MP0005174_abnormal_tail_pigmentation1.99351411
37MP0003136_yellow_coat_color1.85165116
38MP0004134_abnormal_chest_morphology1.79078098
39MP0002160_abnormal_reproductive_system1.70212643
40MP0005084_abnormal_gallbladder_morpholo1.67067741
41MP0000467_abnormal_esophagus_morphology1.66766599
42MP0009250_abnormal_appendicular_skeleto1.66366704
43MP0004133_heterotaxia1.66235748
44MP0008872_abnormal_physiological_respon1.64418335
45MP0003195_calcinosis1.62362452
46MP0002272_abnormal_nervous_system1.59997521
47MP0002277_abnormal_respiratory_mucosa1.59473823
48MP0002139_abnormal_hepatobiliary_system1.56731463
49MP0000762_abnormal_tongue_morphology1.47690768
50MP0002928_abnormal_bile_duct1.44648505
51MP0009931_abnormal_skin_appearance1.44216581
52MP0003011_delayed_dark_adaptation1.44216515
53MP0009053_abnormal_anal_canal1.41766228
54MP0005551_abnormal_eye_electrophysiolog1.41531975
55MP0002876_abnormal_thyroid_physiology1.35720431
56MP0003942_abnormal_urinary_system1.32991198
57MP0003119_abnormal_digestive_system1.32002856
58MP0003566_abnormal_cell_adhesion1.30354068
59MP0001968_abnormal_touch/_nociception1.29193297
60MP0005409_darkened_coat_color1.26209135
61MP0002102_abnormal_ear_morphology1.23743981
62MP0006072_abnormal_retinal_apoptosis1.22357943
63MP0003693_abnormal_embryo_hatching1.20348872
64MP0002734_abnormal_mechanical_nocicepti1.18234246
65MP0000534_abnormal_ureter_morphology1.16674893
66MP0005389_reproductive_system_phenotype1.16294763
67MP0001986_abnormal_taste_sensitivity1.15149054
68MP0009046_muscle_twitch1.14168718
69MP0002735_abnormal_chemical_nociception1.13011310
70MP0000566_synostosis1.12842826
71MP0008877_abnormal_DNA_methylation1.12301185
72MP0002751_abnormal_autonomic_nervous1.10043808
73MP0003941_abnormal_skin_development1.07969864
74MP0004885_abnormal_endolymph1.05992544
75MP0002733_abnormal_thermal_nociception1.04605137
76MP0009745_abnormal_behavioral_response1.02518556
77MP0004742_abnormal_vestibular_system1.01931548
78MP0005379_endocrine/exocrine_gland_phen1.01586871
79MP0000372_irregular_coat_pigmentation1.01298886
80MP0004142_abnormal_muscle_tone0.99592041
81MP0005645_abnormal_hypothalamus_physiol0.98774359
82MP0002064_seizures0.96765445
83MP0001191_abnormal_skin_condition0.93752004
84MP0002557_abnormal_social/conspecific_i0.92761569
85MP0002089_abnormal_postnatal_growth/wei0.91872022
86MP0003183_abnormal_peptide_metabolism0.91496263
87MP0000613_abnormal_salivary_gland0.91011706
88MP0009765_abnormal_xenobiotic_induced0.89706925
89MP0001440_abnormal_grooming_behavior0.86719296
90MP0001529_abnormal_vocalization0.85137965
91MP0003315_abnormal_perineum_morphology0.83661447
92MP0005503_abnormal_tendon_morphology0.83395264
93MP0001963_abnormal_hearing_physiology0.83250179
94MP0001293_anophthalmia0.82336241
95MP0005195_abnormal_posterior_eye0.81761634
96MP0004185_abnormal_adipocyte_glucose0.81190099
97MP0002095_abnormal_skin_pigmentation0.78862878
98MP0001188_hyperpigmentation0.78851289
99MP0001970_abnormal_pain_threshold0.77207539
100MP0003936_abnormal_reproductive_system0.76263982
101MP0000230_abnormal_systemic_arterial0.73139180
102MP0004270_analgesia0.73059292
103MP0005367_renal/urinary_system_phenotyp0.72595515
104MP0000516_abnormal_urinary_system0.72595515
105MP0002932_abnormal_joint_morphology0.71202663
106MP0001661_extended_life_span0.70438520
107MP0002752_abnormal_somatic_nervous0.69369103
108MP0008438_abnormal_cutaneous_collagen0.68828778
109MP0001851_eye_inflammation0.67731647
110MP0001340_abnormal_eyelid_morphology0.67270827
111MP0000750_abnormal_muscle_regeneration0.66515466
112MP0003890_abnormal_embryonic-extraembry0.65083800
113MP0005253_abnormal_eye_physiology0.64638245
114MP0001849_ear_inflammation0.64013209
115MP0002184_abnormal_innervation0.63469652
116MP0004264_abnormal_extraembryonic_tissu0.59848940
117MP0002249_abnormal_larynx_morphology0.59011315
118MP0001346_abnormal_lacrimal_gland0.55476350
119MP0010030_abnormal_orbit_morphology0.53923701
120MP0002282_abnormal_trachea_morphology0.51433015
121MP0003755_abnormal_palate_morphology0.51345457
122MP0005451_abnormal_body_composition0.50889426
123MP0000627_abnormal_mammary_gland0.46407816
124MP0002111_abnormal_tail_morphology0.46199419
125MP0002970_abnormal_white_adipose0.44487328
126MP0005023_abnormal_wound_healing0.44095867
127MP0003385_abnormal_body_wall0.43337510
128MP0003191_abnormal_cellular_cholesterol0.41925785
129MP0001784_abnormal_fluid_regulation0.39700584
130MP0000465_gastrointestinal_hemorrhage0.37952092
131MP0002877_abnormal_melanocyte_morpholog0.36158166
132MP0002697_abnormal_eye_size0.32957933
133MP0002177_abnormal_outer_ear0.31555074
134MP0004272_abnormal_basement_membrane0.30838589
135MP0000537_abnormal_urethra_morphology0.30355558
136MP0000678_abnormal_parathyroid_gland0.29599977
137MP0005075_abnormal_melanosome_morpholog0.28195205
138MP0010368_abnormal_lymphatic_system0.27297082
139MP0004019_abnormal_vitamin_homeostasis0.27199681
140MP0003763_abnormal_thymus_physiology0.26538322
141MP0003950_abnormal_plasma_membrane0.26328648
142MP0010352_gastrointestinal_tract_polyps0.26160725
143MP0004858_abnormal_nervous_system0.24587239
144MP0002233_abnormal_nose_morphology0.21148543
145MP0003935_abnormal_craniofacial_develop0.20785003
146MP0003300_gastrointestinal_ulcer0.20449658
147MP0005666_abnormal_adipose_tissue0.20273639
148MP0000432_abnormal_head_morphology0.20261889
149MP0000049_abnormal_middle_ear0.18095703
150MP0005623_abnormal_meninges_morphology0.18012907
151MP0005375_adipose_tissue_phenotype0.17858198
152MP0000013_abnormal_adipose_tissue0.16541900
153MP0005248_abnormal_Harderian_gland0.15447087
154MP0000751_myopathy0.15214820
155MP0005193_abnormal_anterior_eye0.14591324
156MP0009379_abnormal_foot_pigmentation0.14520961
157MP0005187_abnormal_penis_morphology0.14443031
158MP0001286_abnormal_eye_development0.12559538
159MP0009840_abnormal_foam_cell0.12385192
160MP0005257_abnormal_intraocular_pressure0.12382802
161MP0003329_amyloid_beta_deposits0.12202606
162MP0008569_lethality_at_weaning0.11797871
163MP0000462_abnormal_digestive_system0.11325720
164MP0005508_abnormal_skeleton_morphology0.11285959
165MP0003448_altered_tumor_morphology0.11098757
166MP0000026_abnormal_inner_ear0.10212431
167MP0003638_abnormal_response/metabolism_0.10146491
168MP0005452_abnormal_adipose_tissue0.10014152
169MP0003937_abnormal_limbs/digits/tail_de0.09335844
170MP0003938_abnormal_ear_development0.08137084
171MP0003045_fibrosis0.07948809
172MP0001879_abnormal_lymphatic_vessel0.07790712
173MP0005377_hearing/vestibular/ear_phenot0.07486364
174MP0003878_abnormal_ear_physiology0.07486364

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.77779441
2Nail dystrophy (HP:0008404)7.47615022
3Abnormality of nail color (HP:0100643)5.95514726
4Abnormal hair laboratory examination (HP:0003328)5.56305064
5Fragile nails (HP:0001808)5.45613008
6Fine hair (HP:0002213)5.42812736
7Pendular nystagmus (HP:0012043)5.42482084
8Alopecia of scalp (HP:0002293)4.76886852
9Onycholysis (HP:0001806)4.71559389
10Palmoplantar hyperkeratosis (HP:0000972)4.56046333
11Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)4.52545725
12Short 1st metacarpal (HP:0010034)4.52545725
13Absent rod-and cone-mediated responses on ERG (HP:0007688)4.47782347
14Increased IgE level (HP:0003212)4.35166004
15Thick nail (HP:0001805)4.31591358
16Palmar hyperkeratosis (HP:0010765)4.27751345
17Plantar hyperkeratosis (HP:0007556)4.15420155
18Follicular hyperkeratosis (HP:0007502)4.13091443
19Carpal bone hypoplasia (HP:0001498)4.05247006
20Increased corneal curvature (HP:0100692)4.01831681
21Keratoconus (HP:0000563)4.01831681
22Abnormality of the 1st metacarpal (HP:0010009)3.98101865
23Right ventricular cardiomyopathy (HP:0011663)3.97891291
24Genetic anticipation (HP:0003743)3.68199093
25Abolished electroretinogram (ERG) (HP:0000550)3.65671961
26Decreased central vision (HP:0007663)3.58359127
27Pancreatic fibrosis (HP:0100732)3.54427165
28Stenosis of the external auditory canal (HP:0000402)3.46545176
29Sparse eyelashes (HP:0000653)3.46153691
30Short phalanx of the thumb (HP:0009660)3.41641166
31Erythema (HP:0010783)3.34046938
32Short hallux (HP:0010109)3.29074657
33Abnormality of the frontal sinuses (HP:0002687)3.28386194
34Aplasia/Hypoplasia of the hallux (HP:0008362)3.25620578
35Amelogenesis imperfecta (HP:0000705)3.24408790
36Attenuation of retinal blood vessels (HP:0007843)3.22807805
37Parakeratosis (HP:0001036)3.22433697
38Pancreatic cysts (HP:0001737)3.15139012
39Absent thumb (HP:0009777)3.14825675
40Agitation (HP:0000713)3.12804764
41Milia (HP:0001056)3.11780004
423-Methylglutaconic aciduria (HP:0003535)3.09123596
43Oral leukoplakia (HP:0002745)3.08901671
44True hermaphroditism (HP:0010459)3.06509463
45Methylmalonic acidemia (HP:0002912)3.03172973
46Abnormal rod and cone electroretinograms (HP:0008323)3.00433309
47Porencephaly (HP:0002132)2.98185217
48Oligomenorrhea (HP:0000876)2.82546061
49Visual hallucinations (HP:0002367)2.80014624
50Long nose (HP:0003189)2.76035185
51Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.75823481
52Morphological abnormality of the middle ear (HP:0008609)2.75608174
53Maternal diabetes (HP:0009800)2.74161293
54Curly hair (HP:0002212)2.70151690
55Erythroderma (HP:0001019)2.69543086
56Abnormality of the middle phalanges of the toes (HP:0010183)2.66453501
57Synostosis of carpal bones (HP:0005048)2.66045559
58Abnormality of the proximal phalanges of the hand (HP:0009834)2.62901446
59Aplasia cutis congenita (HP:0001057)2.62578482
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.62313364
61Ridged nail (HP:0001807)2.62010707
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.56283574
63Confusion (HP:0001289)2.53169587
64Fused cervical vertebrae (HP:0002949)2.52236534
65Abnormal number of erythroid precursors (HP:0012131)2.51904739
66Intention tremor (HP:0002080)2.51755249
67Progressive cerebellar ataxia (HP:0002073)2.50241143
68Neck muscle weakness (HP:0000467)2.47970628
69Ectopic kidney (HP:0000086)2.47673886
70Congenital, generalized hypertrichosis (HP:0004540)2.47336417
71Congenital sensorineural hearing impairment (HP:0008527)2.46044662
72Unilateral renal agenesis (HP:0000122)2.43694045
73Abnormality of the nasal septum (HP:0000419)2.42247556
74Abnormality of the renal collecting system (HP:0004742)2.39561729
75Nephronophthisis (HP:0000090)2.38066743
76Decreased subcutaneous fat (HP:0001002)2.36921374
77Abnormality of the phalanges of the 5th finger (HP:0004213)2.36793184
78Furrowed tongue (HP:0000221)2.33909585
79Congenital ichthyosiform erythroderma (HP:0007431)2.33752633
80Septo-optic dysplasia (HP:0100842)2.31911241
81Torticollis (HP:0000473)2.30023263
82Natal tooth (HP:0000695)2.23564695
83Dry hair (HP:0011359)2.23439883
84Abnormality of cells of the erythroid lineage (HP:0012130)2.21188479
85Abnormal blistering of the skin (HP:0008066)2.20527742
86Advanced eruption of teeth (HP:0006288)2.16005416
87Hemiplegia (HP:0002301)2.15129232
88Hypoplasia of the pons (HP:0012110)2.14611565
89Acute necrotizing encephalopathy (HP:0006965)2.14527969
90Diplopia (HP:0000651)2.12742575
91Abnormality of binocular vision (HP:0011514)2.12742575
92Ventricular tachycardia (HP:0004756)2.11703405
93Conjunctival hamartoma (HP:0100780)2.09647141
94Abnormality of the pons (HP:0007361)2.08679802
95Abnormality of secondary sexual hair (HP:0009888)2.07874497
96Abnormality of the axillary hair (HP:0100134)2.07874497
97Hypohidrosis (HP:0000966)2.07159752
98Synostosis involving the elbow (HP:0003938)2.06858304
99Humeroradial synostosis (HP:0003041)2.06858304
100Corneal erosion (HP:0200020)2.05850946
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04348272
102Chorioretinal atrophy (HP:0000533)2.04287194
103Increased purine levels (HP:0004368)2.00614480
104Hyperuricemia (HP:0002149)2.00614480
105Hypotrichosis (HP:0001006)14.9969168
106Abnormality of hair growth rate (HP:0011363)11.3936864
107Slow-growing hair (HP:0002217)11.3936864
108Woolly hair (HP:0002224)10.8930672
109Brittle hair (HP:0002299)10.6235527
110Sclerocornea (HP:0000647)1.99908711
111Gaze-evoked nystagmus (HP:0000640)1.97046489
112Methylmalonic aciduria (HP:0012120)1.95592488
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94871748
114Abnormality of the parietal bone (HP:0002696)1.94169571
115Abnormality of the pupil (HP:0000615)1.94125404
116Asplenia (HP:0001746)1.93676934
117Symphalangism affecting the phalanges of the hand (HP:0009773)1.92850113
118Congenital stationary night blindness (HP:0007642)1.91384322
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.91051138
120Cystic liver disease (HP:0006706)1.90368063
121Craniofacial dystonia (HP:0012179)1.90279881
122Pruritus (HP:0000989)1.89885213
123Abnormal mitochondria in muscle tissue (HP:0008316)1.89868899
124Acanthocytosis (HP:0001927)1.89483914
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89358263
126Abnormality of homocysteine metabolism (HP:0010919)1.88295130
127Homocystinuria (HP:0002156)1.88295130
128Palmoplantar keratoderma (HP:0000982)1.87419184
129Abnormality of the costochondral junction (HP:0000919)1.87091266
130Abnormality of the dental root (HP:0006486)1.86065202
131Taurodontia (HP:0000679)1.86065202
132Abnormality of permanent molar morphology (HP:0011071)1.86065202
133Abnormality of molar (HP:0011077)1.85772013
134Abnormality of molar morphology (HP:0011070)1.85772013
135Widely patent fontanelles and sutures (HP:0004492)1.84373458
136Progressive macrocephaly (HP:0004481)1.84360274
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.83608167
138Gonadotropin excess (HP:0000837)1.83262690
139Bony spicule pigmentary retinopathy (HP:0007737)1.81427981
140Reticulocytopenia (HP:0001896)1.81052808
141Vertebral fusion (HP:0002948)1.80978443
142Toxemia of pregnancy (HP:0100603)1.80881139
143Lip pit (HP:0100267)1.79988812
144Difficulty walking (HP:0002355)1.79109979
145Abnormality of subcutaneous fat tissue (HP:0001001)1.76982970
146Pallor (HP:0000980)1.76951211
147Chronic hepatic failure (HP:0100626)1.76696715
148Abnormality of the renal medulla (HP:0100957)1.76673035
149Hypoplasia of the uterus (HP:0000013)1.76062837
150Abnormality of the upper arm (HP:0001454)1.75662686
151Focal dystonia (HP:0004373)1.73494596
152Concave nail (HP:0001598)1.70255807
153Ventricular fibrillation (HP:0001663)1.67558927
154Recurrent corneal erosions (HP:0000495)1.66946655
155Abnormality of the dental pulp (HP:0006479)1.61875973
156Abnormality of dental color (HP:0011073)1.61635597
157Hyporeflexia of lower limbs (HP:0002600)1.60741079
158Distal lower limb muscle weakness (HP:0009053)1.57894373
159Absent eyelashes (HP:0000561)1.57666842
160Abnormality of the aortic arch (HP:0012303)1.55667079
161Fatigable weakness (HP:0003473)1.54046571
162Abnormality of the neuromuscular junction (HP:0003398)1.54046571
163Heterogeneous (HP:0001425)1.49172134
164Sudden death (HP:0001699)1.42595210
165Amniotic constriction ring (HP:0009775)1.40821642
166Abnormality of placental membranes (HP:0011409)1.40821642
167Craniofacial hyperostosis (HP:0004493)1.39292970
168Carious teeth (HP:0000670)1.38364561
169Blepharitis (HP:0000498)1.36743596
170Acanthosis nigricans (HP:0000956)1.35825878
171Keratoconjunctivitis sicca (HP:0001097)1.35577912
172Distal lower limb amyotrophy (HP:0008944)1.31763475
173Variable expressivity (HP:0003828)1.30121439
174Achilles tendon contracture (HP:0001771)1.29065817
175Atrophic scars (HP:0001075)1.28492875
176Sparse scalp hair (HP:0002209)1.28141155
177Widely spaced teeth (HP:0000687)1.27917631
178Hypergammaglobulinemia (HP:0010702)1.27589961
179Autoamputation (HP:0001218)1.26515158
180Neonatal onset (HP:0003623)1.25252314
181Ectropion (HP:0000656)1.24904203
182Congenital malformation of the right heart (HP:0011723)1.24211375
183Double outlet right ventricle (HP:0001719)1.24211375
184Laryngomalacia (HP:0001601)1.23083791
185Gangrene (HP:0100758)1.22593035
186Abnormality of the fingernails (HP:0001231)1.21689779
187Abnormality of the Achilles tendon (HP:0005109)1.21381486
188Anonychia (HP:0001798)1.19778590
189Type 1 muscle fiber predominance (HP:0003803)1.19765491
190Keratoconjunctivitis (HP:0001096)1.18425671
191Corneal dystrophy (HP:0001131)1.18138724
192Round ear (HP:0100830)1.16661825
193Selective tooth agenesis (HP:0001592)1.14863009

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FER4.42146194
2EPHA24.31209313
3GRK14.26738820
4ADRBK23.86783919
5MAP3K63.77636941
6EPHB23.69193961
7MAPKAPK33.55943012
8ERN13.46760411
9NUAK13.39849074
10INSRR3.20602120
11VRK23.13740840
12FRK3.06151370
13TAF12.90714355
14TAOK12.73020997
15TRIB32.44711530
16PINK12.43346590
17MAP3K32.40005003
18TAOK32.38036644
19LATS12.37813500
20MAP3K22.16254720
21TLK12.12525305
22BMPR1B2.07664021
23PIK3CG1.95190601
24WNK31.85397933
25ZAK1.84731935
26TTN1.83568609
27PRKD21.83249305
28EPHB11.77719317
29LATS21.77585341
30CDK91.73137305
31MAP4K21.72652954
32RPS6KB21.71747615
33PNCK1.71203597
34TNIK1.71157557
35STK161.70752911
36VRK11.69788388
37MAP2K61.62107840
38PDGFRA1.59245571
39MAP3K111.58026064
40MAPKAPK51.57592196
41EEF2K1.52142750
42RIPK11.50252784
43MUSK1.45495852
44NME11.43210259
45NME21.38081177
46MAP3K11.35962574
47BCR1.30190759
48BLK1.25528435
49FGFR41.17298426
50PAK61.12082787
51CAMK1D1.11254030
52MAP3K71.10960436
53DYRK21.08585633
54RPS6KA51.06181529
55PTK61.02622605
56BMX1.02154827
57MAP3K91.01115997
58KSR21.01040347
59ADRBK11.00899918
60PRKCG0.99897675
61PTK20.99340492
62OBSCN0.97646643
63DYRK30.96754986
64TXK0.96277448
65PAK30.96045916
66MST1R0.95754454
67FGFR10.95753056
68WNK40.95097227
69MAPKAPK20.94908227
70PLK20.94520373
71NTRK30.91809842
72CAMKK20.91314196
73FGFR20.87785586
74STK38L0.87702915
75CDK60.87174640
76GRK50.86208171
77IKBKB0.85761015
78CAMK1G0.85746960
79NEK90.85102157
80MAP2K10.84109463
81DYRK1B0.82558028
82MAPK130.80594019
83PKN20.79553037
84ALK0.78011330
85FGFR30.76294548
86CDC70.76114208
87TIE10.75909962
88GRK70.74994831
89MAP2K30.74377460
90MAP2K40.74271599
91STK380.73274023
92CLK10.72930589
93IRAK10.71499785
94PRKD10.70859421
95FLT30.69477964
96PAK20.68949943
97NTRK10.67788585
98ERBB40.67109594
99NTRK20.67014296
100DDR20.66790670
101PRKCI0.66300121
102MAP3K100.65130773
103LRRK20.63338595
104MAP2K20.62784664
105OXSR10.62330417
106CSNK1G30.62272612
107CDK190.62090561
108KSR10.61731755
109RPS6KA60.61222169
110PHKG10.60860047
111PHKG20.60860047
112CAMK10.59731743
113PASK0.59297325
114PBK0.57584512
115PRKCE0.57336958
116ACVR1B0.56463030
117CSNK1G10.54096076
118MAP4K10.53975796
119PRKCH0.53882529
120RPS6KB10.53021902
121ERBB20.52975930
122RPS6KA40.52505644
123DAPK20.51953010
124PAK40.51809492
125MAPK150.51754678
126CSNK1E0.51362625
127STK390.50439679
128CAMKK10.50236071
129TNK20.49904953
130MAPK120.49390604
131PTK2B0.49359994
132SIK10.47507997
133CHEK20.47348990
134TRPM70.45543459
135PIM20.45322107
136TGFBR10.45244084
137MKNK20.44667800
138CHUK0.43891133
139HCK0.42860003
140CSNK1A1L0.42784062
141CSNK1G20.42308733
142PRKCQ0.41606530
143CAMK2A0.39491934
144TESK10.39165400
145FGR0.39148315
146MAPK40.39028839
147MET0.38589938
148RPS6KA10.38095258
149AURKA0.37715105
150JAK10.37655406
151STK110.37627017
152EIF2AK20.36965389
153FYN0.36577017
154MATK0.36391831
155PKN10.36382279
156HIPK20.35197773
157DAPK30.35074893
158SRC0.34960402
159BRSK20.34799617
160PRKCZ0.34579708
161BCKDK0.33741905
162CSNK1D0.33588068
163RPS6KL10.33241586
164RPS6KC10.33241586
165PRKACG0.32954554
166EPHA30.32822496
167MAP3K80.32635583
168GSK3A0.32611534
169CASK0.32430477
170PRKACA0.32366095
171TYK20.32323838
172MARK10.31350023
173MAP3K50.31076525
174ATR0.30493162
175GRK60.30379308
176CSNK1A10.29062892
177FES0.28867902
178IKBKE0.28779992
179TGFBR20.27842231
180TAOK20.27689478

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.22938686
2Linoleic acid metabolism_Homo sapiens_hsa005915.21188337
3Ribosome_Homo sapiens_hsa030103.56527983
4Ether lipid metabolism_Homo sapiens_hsa005653.00581263
5Fat digestion and absorption_Homo sapiens_hsa049752.89300773
6Fatty acid elongation_Homo sapiens_hsa000622.79315415
7Oxidative phosphorylation_Homo sapiens_hsa001902.73417522
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56999612
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.49274585
10Sulfur metabolism_Homo sapiens_hsa009202.42233857
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39103991
12Selenocompound metabolism_Homo sapiens_hsa004502.37387095
13Nicotine addiction_Homo sapiens_hsa050332.29245456
14Parkinsons disease_Homo sapiens_hsa050122.25676599
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13057231
16Basal cell carcinoma_Homo sapiens_hsa052172.12394912
17Phenylalanine metabolism_Homo sapiens_hsa003602.05910804
18Arachidonic acid metabolism_Homo sapiens_hsa005902.01239052
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.96796612
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.82687536
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81145884
22Alzheimers disease_Homo sapiens_hsa050101.79501435
23Homologous recombination_Homo sapiens_hsa034401.64432292
24RNA polymerase_Homo sapiens_hsa030201.63875385
25Glycerolipid metabolism_Homo sapiens_hsa005611.62511199
26VEGF signaling pathway_Homo sapiens_hsa043701.62508332
27Axon guidance_Homo sapiens_hsa043601.61326972
28Taste transduction_Homo sapiens_hsa047421.58552827
29Melanogenesis_Homo sapiens_hsa049161.53945995
30Huntingtons disease_Homo sapiens_hsa050161.53657625
31Vitamin digestion and absorption_Homo sapiens_hsa049771.49045944
32Morphine addiction_Homo sapiens_hsa050321.48668684
33Cardiac muscle contraction_Homo sapiens_hsa042601.47251377
34Hedgehog signaling pathway_Homo sapiens_hsa043401.41031689
35beta-Alanine metabolism_Homo sapiens_hsa004101.36453896
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35176353
37Tryptophan metabolism_Homo sapiens_hsa003801.33427711
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.30065175
39Histidine metabolism_Homo sapiens_hsa003401.29562553
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.28750091
41Systemic lupus erythematosus_Homo sapiens_hsa053221.24166653
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22232586
43GnRH signaling pathway_Homo sapiens_hsa049121.19317568
44Melanoma_Homo sapiens_hsa052181.19059443
45Basal transcription factors_Homo sapiens_hsa030221.18672845
46Hippo signaling pathway_Homo sapiens_hsa043901.15480681
47Retinol metabolism_Homo sapiens_hsa008301.12669717
48ECM-receptor interaction_Homo sapiens_hsa045121.10740114
49Caffeine metabolism_Homo sapiens_hsa002321.10439642
50Acute myeloid leukemia_Homo sapiens_hsa052211.08885797
51Asthma_Homo sapiens_hsa053101.08546839
52Glioma_Homo sapiens_hsa052141.07749518
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02881752
54Pancreatic secretion_Homo sapiens_hsa049721.02669502
55Bladder cancer_Homo sapiens_hsa052191.01855137
56RNA degradation_Homo sapiens_hsa030181.00663081
57Tyrosine metabolism_Homo sapiens_hsa003500.99833663
58PPAR signaling pathway_Homo sapiens_hsa033200.99596757
59Proteoglycans in cancer_Homo sapiens_hsa052050.99548689
60Tight junction_Homo sapiens_hsa045300.98196667
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98161467
62Long-term depression_Homo sapiens_hsa047300.96237272
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.96093386
64Dorso-ventral axis formation_Homo sapiens_hsa043200.95608061
65Phototransduction_Homo sapiens_hsa047440.95505352
66Estrogen signaling pathway_Homo sapiens_hsa049150.92495658
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91238683
68Ras signaling pathway_Homo sapiens_hsa040140.87837916
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87560157
70Steroid biosynthesis_Homo sapiens_hsa001000.87272792
71Thyroid cancer_Homo sapiens_hsa052160.87011257
72Insulin secretion_Homo sapiens_hsa049110.86650762
73Calcium signaling pathway_Homo sapiens_hsa040200.85508515
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85484150
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85012544
76Amoebiasis_Homo sapiens_hsa051460.84106505
77Fanconi anemia pathway_Homo sapiens_hsa034600.83312322
78Gastric acid secretion_Homo sapiens_hsa049710.82413774
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82210090
80Wnt signaling pathway_Homo sapiens_hsa043100.80838319
81Pertussis_Homo sapiens_hsa051330.80515369
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78166397
83Long-term potentiation_Homo sapiens_hsa047200.77849976
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77755405
85Glutamatergic synapse_Homo sapiens_hsa047240.76432770
86Sulfur relay system_Homo sapiens_hsa041220.76280565
87One carbon pool by folate_Homo sapiens_hsa006700.74632906
88Mineral absorption_Homo sapiens_hsa049780.70975081
89Adherens junction_Homo sapiens_hsa045200.70249030
90DNA replication_Homo sapiens_hsa030300.68952952
91GABAergic synapse_Homo sapiens_hsa047270.68376512
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67934153
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67792007
94Staphylococcus aureus infection_Homo sapiens_hsa051500.66661736
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66429226
96Circadian entrainment_Homo sapiens_hsa047130.65767013
97Butanoate metabolism_Homo sapiens_hsa006500.65691088
98Cocaine addiction_Homo sapiens_hsa050300.64409115
99Nitrogen metabolism_Homo sapiens_hsa009100.64203744
100Endometrial cancer_Homo sapiens_hsa052130.63226052
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62989195
102Non-homologous end-joining_Homo sapiens_hsa034500.62344039
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61021828
104Fatty acid metabolism_Homo sapiens_hsa012120.60877005
105Renin-angiotensin system_Homo sapiens_hsa046140.60155540
106MicroRNAs in cancer_Homo sapiens_hsa052060.59779052
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58767022
108TGF-beta signaling pathway_Homo sapiens_hsa043500.57010008
109Oxytocin signaling pathway_Homo sapiens_hsa049210.56475972
110Non-small cell lung cancer_Homo sapiens_hsa052230.56090060
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.55203860
112Protein digestion and absorption_Homo sapiens_hsa049740.54273243
113Insulin resistance_Homo sapiens_hsa049310.54204123
114Purine metabolism_Homo sapiens_hsa002300.53399373
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53283130
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.52170989
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52052497
118Starch and sucrose metabolism_Homo sapiens_hsa005000.51610216
119Renin secretion_Homo sapiens_hsa049240.51299058
120Alcoholism_Homo sapiens_hsa050340.50871276
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50735434
122Platelet activation_Homo sapiens_hsa046110.50557431
123Ovarian steroidogenesis_Homo sapiens_hsa049130.50249510
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50216073
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50114061
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.49993005
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49480909
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49353603
129Focal adhesion_Homo sapiens_hsa045100.49324908
130Olfactory transduction_Homo sapiens_hsa047400.49269742
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48730849
132Type II diabetes mellitus_Homo sapiens_hsa049300.48693301
133p53 signaling pathway_Homo sapiens_hsa041150.47616002
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47553132
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46991737
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46848334
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46278684
138Dilated cardiomyopathy_Homo sapiens_hsa054140.46166203
139Fatty acid biosynthesis_Homo sapiens_hsa000610.45072858
140Rap1 signaling pathway_Homo sapiens_hsa040150.44809177
141Salivary secretion_Homo sapiens_hsa049700.42523242
142ErbB signaling pathway_Homo sapiens_hsa040120.42512866
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42268902
144MAPK signaling pathway_Homo sapiens_hsa040100.42226886
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41527732
146cAMP signaling pathway_Homo sapiens_hsa040240.41366337
147Primary immunodeficiency_Homo sapiens_hsa053400.41037456
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.40907514
149ABC transporters_Homo sapiens_hsa020100.40296160
150Collecting duct acid secretion_Homo sapiens_hsa049660.40115333
151Graft-versus-host disease_Homo sapiens_hsa053320.39619401
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39560506
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39147857
154Metabolic pathways_Homo sapiens_hsa011000.38785476
155Type I diabetes mellitus_Homo sapiens_hsa049400.38662166
156Cyanoamino acid metabolism_Homo sapiens_hsa004600.37573743
157Serotonergic synapse_Homo sapiens_hsa047260.37417765
158Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37056106
159Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37031144
160Gap junction_Homo sapiens_hsa045400.36691909
161Notch signaling pathway_Homo sapiens_hsa043300.36515270
162Bile secretion_Homo sapiens_hsa049760.36337182
163Chemical carcinogenesis_Homo sapiens_hsa052040.34349465
164Fatty acid degradation_Homo sapiens_hsa000710.33487505
165Dopaminergic synapse_Homo sapiens_hsa047280.33343504
166Toxoplasmosis_Homo sapiens_hsa051450.32709616
167Renal cell carcinoma_Homo sapiens_hsa052110.32446618

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