ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.99802967
2	adhesion of symbiont to host cell (GO:0044650)	9.99802967
3	citrulline biosynthetic process (GO:0019240)	8.74578303
4	adhesion of symbiont to host (GO:0044406)	8.42258842
5	peptide cross-linking (GO:0018149)	8.37259819
6	hair follicle morphogenesis (GO:0031069)	7.96554728
7	cell wall macromolecule metabolic process (GO:0044036)	6.97840562
8	cell wall macromolecule catabolic process (GO:0016998)	6.97840562
9	intermediate filament cytoskeleton organization (GO:0045104)	6.66235080
10	establishment of skin barrier (GO:0061436)	6.49366525
11	intermediate filament-based process (GO:0045103)	6.44977005
12	epidermis development (GO:0008544)	6.28989514
13	keratinocyte differentiation (GO:0030216)	6.02143937
14	citrulline metabolic process (GO:0000052)	5.76873702
15	regulation of water loss via skin (GO:0033561)	5.72745458
16	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.35030328
17	hair cycle process (GO:0022405)	5.30714705
18	molting cycle process (GO:0022404)	5.30714705
19	skin morphogenesis (GO:0043589)	5.27677500
20	hemidesmosome assembly (GO:0031581)	5.15831617
21	peptidyl-arginine modification (GO:0018195)	4.85664309
22	epidermal cell differentiation (GO:0009913)	4.71421550
23	tooth mineralization (GO:0034505)	4.12885949
24	hair cycle (GO:0042633)	33.7586244
25	molting cycle (GO:0042303)	33.7586244
26	keratinocyte development (GO:0003334)	3.91285410
27	multicellular organismal water homeostasis (GO:0050891)	3.85339256
28	negative regulation of keratinocyte proliferation (GO:0010839)	3.42764473
29	hair follicle development (GO:0001942)	3.32458465
30	positive regulation of hair cycle (GO:0042635)	3.25566136
31	positive regulation of hair follicle development (GO:0051798)	3.25566136
32	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.17698936
33	regulation of keratinocyte differentiation (GO:0045616)	3.17604282
34	water homeostasis (GO:0030104)	3.15540095
35	fatty acid elongation (GO:0030497)	3.15249847
36	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.14795977
37	bone trabecula formation (GO:0060346)	3.10648996
38	regulation of hair follicle development (GO:0051797)	3.09566871
39	ectoderm development (GO:0007398)	3.01524567
40	epithelium development (GO:0060429)	2.98922343
41	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.88430787
42	gap junction assembly (GO:0016264)	2.86970634
43	positive regulation of meiotic cell cycle (GO:0051446)	2.79301369
44	atrioventricular valve morphogenesis (GO:0003181)	2.78985073
45	regulation of hair cycle (GO:0042634)	2.77875726
46	positive regulation of epidermis development (GO:0045684)	2.75300643
47	negative regulation of protein localization to plasma membrane (GO:1903077)	2.60999467
48	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.58803295
49	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.53108575
50	negative regulation of cell fate specification (GO:0009996)	2.49800538
51	regulation of epidermal cell differentiation (GO:0045604)	2.49064263
52	regulation of epidermis development (GO:0045682)	2.44666116
53	ventricular cardiac muscle cell action potential (GO:0086005)	2.43456015
54	lymph vessel development (GO:0001945)	2.41622686
55	skin development (GO:0043588)	2.37908258
56	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.37328368
57	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.36968099
58	wound healing, spreading of epidermal cells (GO:0035313)	2.25260033
59	positive regulation of epidermal cell differentiation (GO:0045606)	2.25097302
60	cranial suture morphogenesis (GO:0060363)	2.21969550
61	phosphatidylserine metabolic process (GO:0006658)	2.19571114
62	myotube differentiation (GO:0014902)	2.18103403
63	regulation of cardioblast differentiation (GO:0051890)	2.17373066
64	epithelial cell-cell adhesion (GO:0090136)	2.12833753
65	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.12097612
66	outflow tract septum morphogenesis (GO:0003148)	2.11757903
67	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.11568085
68	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.09264623
69	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.08415131
70	positive regulation of monocyte chemotaxis (GO:0090026)	2.07612100
71	negative regulation of epidermis development (GO:0045683)	2.04987030
72	regulation of heart rate by cardiac conduction (GO:0086091)	2.03449782
73	intermediate filament organization (GO:0045109)	11.9972813
74	keratinization (GO:0031424)	11.8723027
75	desmosome organization (GO:0002934)	10.5153825
76	regulation of ruffle assembly (GO:1900027)	1.97659291
77	aging (GO:0007568)	1.96982582
78	regulation of keratinocyte proliferation (GO:0010837)	1.96334145
79	keratinocyte proliferation (GO:0043616)	1.95091672
80	cell communication involved in cardiac conduction (GO:0086065)	1.94497473
81	non-canonical Wnt signaling pathway (GO:0035567)	1.93869235
82	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.92944126
83	cell-substrate junction assembly (GO:0007044)	1.90439970
84	ephrin receptor signaling pathway (GO:0048013)	1.88219962
85	coronary vasculature morphogenesis (GO:0060977)	1.88064929
86	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.85843745
87	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.82248700
88	regulation of cardioblast proliferation (GO:0003264)	1.82248700
89	very long-chain fatty acid metabolic process (GO:0000038)	1.82186964
90	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.80978485
91	negative regulation of cell fate commitment (GO:0010454)	1.74539322
92	outer ear morphogenesis (GO:0042473)	1.71053265
93	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	1.70485541
94	establishment of planar polarity (GO:0001736)	1.70282174
95	establishment of tissue polarity (GO:0007164)	1.70282174
96	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.69889770
97	fatty-acyl-CoA biosynthetic process (GO:0046949)	1.69831004
98	cardiac right ventricle morphogenesis (GO:0003215)	1.69609244
99	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.68006783
100	primary alcohol catabolic process (GO:0034310)	1.66650483

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.80262041
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.75825492
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.52436258
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.86665764
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.22252718
6	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.07955672
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.7002304
8	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.98806409
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.83493242
10	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.80101436
11	E2F1_20622854_ChIP-Seq_HELA_Human	1.78403782
12	EGR1_19032775_ChIP-ChIP_M12_Human	1.75933233
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75678508
14	TAF2_19829295_ChIP-Seq_ESCs_Human	1.73280400
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.69643639
16	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.65514345
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.62357897
18	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.54749673
19	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.52936009
20	RACK7_27058665_Chip-Seq_MCF-7_Human	1.52404962
21	P53_21459846_ChIP-Seq_SAOS-2_Human	1.48896098
22	LXR_22292898_ChIP-Seq_THP-1_Human	1.48601787
23	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.47886007
24	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.47886007
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.46190253
26	* CTCF_27219007_Chip-Seq_Bcells_Human	1.44278088
27	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.43781633
28	BCL6_27268052_Chip-Seq_Bcells_Human	1.43130193
29	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.42810474
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.42501983
31	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.42265105
32	* TP63_22573176_ChIP-Seq_HFKS_Human	1.41604969
33	ATF3_27146783_Chip-Seq_COLON_Human	1.35876332
34	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.35595973
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.34784233
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.31828629
37	* ERG_20517297_ChIP-Seq_VCAP_Human	1.30929177
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.30429801
39	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.30087227
40	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27295881
41	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.22085149
42	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21332965
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.20940463
44	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.20723771
45	PHF8_20622854_ChIP-Seq_HELA_Human	1.19147367
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18865264
47	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.18564973
48	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16642129
49	P68_20966046_ChIP-Seq_HELA_Human	1.15708103
50	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15595562
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.15024253
52	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.12201744
53	TP63_23658742_ChIP-Seq_EP156T_Human	1.11343086
54	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.08354315
55	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07274765
56	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07118542
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.06649840
58	SMC4_20622854_ChIP-Seq_HELA_Human	1.06528569
59	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06386388
60	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.04992953
61	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04538532
62	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.04225682
63	GATA4_25053715_ChIP-Seq_YYC3_Human	1.03594230
64	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.02840998
65	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.02769295
66	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01619913
67	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00489534
68	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98576623
69	SOX2_21211035_ChIP-Seq_LN229_Human	0.95922390
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95708517
71	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.93211688
72	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.93053336
73	ZNF263_19887448_ChIP-Seq_K562_Human	0.92651786
74	SPI1_20517297_ChIP-Seq_HL60_Human	0.91077687
75	AR_21572438_ChIP-Seq_LNCaP_Human	0.90793689
76	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.90695621
77	TP53_18474530_ChIP-ChIP_U2OS_Human	0.90616667
78	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.90422053
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89946784
80	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.89890051
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.89595745
82	RXR_22108803_ChIP-Seq_LS180_Human	0.89416359
83	* SA1_27219007_Chip-Seq_ERYTHROID_Human	0.89218767
84	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.87894053
85	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.87416170
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87334967
87	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.85362096
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.84284708
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81825819
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.81803482
91	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.81562188
92	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78978866
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.77434804
94	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.76963589
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.74107466
96	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.73992233
97	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.73279174
98	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.71996818
99	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.70266443
100	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.70261705

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.70821455
2	MP0002098_abnormal_vibrissa_morphology	6.82029450
3	MP0000647_abnormal_sebaceous_gland	6.22403279
4	MP0002796_impaired_skin_barrier	6.17365362
5	MP0005275_abnormal_skin_tensile	5.37300614
6	MP0010234_abnormal_vibrissa_follicle	4.89732571
7	MP0000383_abnormal_hair_follicle	4.60913063
8	MP0010678_abnormal_skin_adnexa	4.05875641
9	MP0000377_abnormal_hair_follicle	3.99915156
10	MP0005501_abnormal_skin_physiology	3.83079605
11	MP0003705_abnormal_hypodermis_morpholog	3.64600909
12	MP0000427_abnormal_hair_cycle	3.52578711
13	MP0002254_reproductive_system_inflammat	3.00999199
14	MP0001216_abnormal_epidermal_layer	2.73141345
15	MP0004381_abnormal_hair_follicle	2.55094300
16	MP0010771_integument_phenotype	2.37332081
17	MP0004947_skin_inflammation	2.33679301
18	MP0000367_abnormal_coat/_hair	2.29683462
19	MP0002060_abnormal_skin_morphology	2.25250292
20	MP0001243_abnormal_dermal_layer	2.18013970
21	MP0003453_abnormal_keratinocyte_physiol	2.17802266
22	MP0002234_abnormal_pharynx_morphology	1.96982328
23	MP0000467_abnormal_esophagus_morphology	1.78750465
24	MP0009931_abnormal_skin_appearance	1.52275634
25	MP0000762_abnormal_tongue_morphology	1.51195831
26	MP0009053_abnormal_anal_canal	1.44255787
27	MP0003566_abnormal_cell_adhesion	1.40288454
28	MP0005409_darkened_coat_color	1.36435674
29	MP0003941_abnormal_skin_development	1.28582850
30	MP0001191_abnormal_skin_condition	1.03981134
31	MP0002095_abnormal_skin_pigmentation	0.93484169
32	MP0004185_abnormal_adipocyte_glucose	0.92939497
33	MP0004885_abnormal_endolymph	0.92745211
34	MP0008438_abnormal_cutaneous_collagen	0.89440485
35	MP0004264_abnormal_extraembryonic_tissu	0.87160225
36	MP0001851_eye_inflammation	0.76567922
37	MP0001346_abnormal_lacrimal_gland	0.72285235
38	MP0001340_abnormal_eyelid_morphology	0.69033364
39	MP0001661_extended_life_span	0.68671996
40	MP0010030_abnormal_orbit_morphology	0.68075281
41	MP0001849_ear_inflammation	0.67688288
42	MP0000566_synostosis	0.64086082
43	MP0003315_abnormal_perineum_morphology	0.61775708
44	MP0002877_abnormal_melanocyte_morpholog	0.60291745
45	MP0009379_abnormal_foot_pigmentation	0.57739036
46	MP0002282_abnormal_trachea_morphology	0.56474177
47	MP0000627_abnormal_mammary_gland	0.54806665
48	MP0003191_abnormal_cellular_cholesterol	0.52761463
49	MP0003755_abnormal_palate_morphology	0.52181760
50	MP0001784_abnormal_fluid_regulation	0.49607977
51	MP0005023_abnormal_wound_healing	0.49371058
52	MP0005451_abnormal_body_composition	0.49215346
53	MP0002249_abnormal_larynx_morphology	0.47512939
54	MP0002970_abnormal_white_adipose	0.42626631
55	MP0002111_abnormal_tail_morphology	0.40867469
56	MP0000678_abnormal_parathyroid_gland	0.39107184
57	MP0002177_abnormal_outer_ear	0.37814651
58	MP0005075_abnormal_melanosome_morpholog	0.36892741
59	MP0010352_gastrointestinal_tract_polyps	0.34378649
60	MP0003385_abnormal_body_wall	0.34197603
61	MP0004272_abnormal_basement_membrane	0.33726345
62	MP0000537_abnormal_urethra_morphology	0.30789103
63	MP0002697_abnormal_eye_size	0.26506535
64	MP0005248_abnormal_Harderian_gland	0.25312553
65	MP0009840_abnormal_foam_cell	0.25178240
66	MP0003950_abnormal_plasma_membrane	0.24902091
67	MP0000465_gastrointestinal_hemorrhage	0.23666341
68	MP0000432_abnormal_head_morphology	0.22497730
69	MP0003763_abnormal_thymus_physiology	0.22443283
70	MP0006054_spinal_hemorrhage	0.21816072
71	MP0003300_gastrointestinal_ulcer	0.20075865
72	MP0005367_renal/urinary_system_phenotyp	0.19899431
73	MP0000516_abnormal_urinary_system	0.19899431
74	MP0003935_abnormal_craniofacial_develop	0.18476230
75	MP0003329_amyloid_beta_deposits	0.17728287
76	MP0000751_myopathy	0.17511447
77	MP0001879_abnormal_lymphatic_vessel	0.16631239
78	MP0004019_abnormal_vitamin_homeostasis	0.16084777
79	MP0005666_abnormal_adipose_tissue	0.15705077
80	MP0002166_altered_tumor_susceptibility	0.15226531
81	MP0005076_abnormal_cell_differentiation	0.14901406
82	MP0002006_tumorigenesis	0.14781524
83	MP0005375_adipose_tissue_phenotype	0.14638930
84	MP0000733_abnormal_muscle_development	0.12905124
85	MP0003448_altered_tumor_morphology	0.12334497
86	MP0009384_cardiac_valve_regurgitation	0.12140829
87	MP0003011_delayed_dark_adaptation	0.12099940
88	MP0000462_abnormal_digestive_system	0.11923965
89	MP0002009_preneoplasia	0.11394400
90	MP0004742_abnormal_vestibular_system	0.11344624
91	MP0003638_abnormal_response/metabolism_	0.11102002
92	MP0002233_abnormal_nose_morphology	0.10940886
93	MP0005508_abnormal_skeleton_morphology	0.10588689
94	MP0005193_abnormal_anterior_eye	0.10528465
95	MP0001958_emphysema	0.09606760
96	MP0003045_fibrosis	0.09556805
97	MP0004858_abnormal_nervous_system	0.09513904
98	MP0000428_abnormal_craniofacial_morphol	0.07805737
99	MP0000604_amyloidosis	0.07143164
100	MP0000013_abnormal_adipose_tissue	0.06843256

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Brittle hair (HP:0002299)	9.63285130
2	Pili torti (HP:0003777)	9.19145029
3	Nail dystrophy (HP:0008404)	7.04432655
4	Abnormality of nail color (HP:0100643)	6.62626610
5	Abnormal hair laboratory examination (HP:0003328)	5.78527527
6	Fragile nails (HP:0001808)	5.68299168
7	Alopecia of scalp (HP:0002293)	5.27594184
8	Palmoplantar hyperkeratosis (HP:0000972)	5.06360717
9	Onycholysis (HP:0001806)	5.03471570
10	Increased IgE level (HP:0003212)	5.02271068
11	Fine hair (HP:0002213)	4.97522441
12	Palmar hyperkeratosis (HP:0010765)	4.76856807
13	Follicular hyperkeratosis (HP:0007502)	4.75298996
14	Thick nail (HP:0001805)	4.66104267
15	Plantar hyperkeratosis (HP:0007556)	4.61231387
16	Right ventricular cardiomyopathy (HP:0011663)	4.28898276
17	Erythema (HP:0010783)	3.82047505
18	Sparse eyelashes (HP:0000653)	3.63522097
19	Oral leukoplakia (HP:0002745)	3.52571365
20	Milia (HP:0001056)	3.28843091
21	Amelogenesis imperfecta (HP:0000705)	3.15367894
22	Abnormality of the frontal sinuses (HP:0002687)	3.14772018
23	Erythroderma (HP:0001019)	3.09542484
24	Parakeratosis (HP:0001036)	2.86986856
25	Congenital, generalized hypertrichosis (HP:0004540)	2.80740602
26	Curly hair (HP:0002212)	2.74500744
27	Ridged nail (HP:0001807)	2.70645177
28	Congenital ichthyosiform erythroderma (HP:0007431)	2.64844012
29	Abnormal blistering of the skin (HP:0008066)	2.57866206
30	Aplasia cutis congenita (HP:0001057)	2.51378020
31	Intention tremor (HP:0002080)	2.51315869
32	Neck muscle weakness (HP:0000467)	2.41635605
33	Natal tooth (HP:0000695)	2.39126577
34	Advanced eruption of teeth (HP:0006288)	2.38025067
35	Dry hair (HP:0011359)	2.21838199
36	Torticollis (HP:0000473)	2.16971088
37	Hypohidrosis (HP:0000966)	2.12939184
38	Corneal erosion (HP:0200020)	2.11747010
39	Palmoplantar keratoderma (HP:0000982)	2.11448189
40	Ventricular tachycardia (HP:0004756)	2.06831211
41	Hypotrichosis (HP:0001006)	14.2485395
42	Woolly hair (HP:0002224)	11.0183941
43	Slow-growing hair (HP:0002217)	10.4139774
44	Abnormality of hair growth rate (HP:0011363)	10.4139774
45	Pruritus (HP:0000989)	1.95609962
46	Conjunctival hamartoma (HP:0100780)	1.93652035
47	Concave nail (HP:0001598)	1.87468736
48	Craniofacial dystonia (HP:0012179)	1.81711692
49	Difficulty walking (HP:0002355)	1.81482794
50	Abnormality of the dental root (HP:0006486)	1.77160692
51	Taurodontia (HP:0000679)	1.77160692
52	Abnormality of permanent molar morphology (HP:0011071)	1.77160692
53	Abnormality of the parietal bone (HP:0002696)	1.77113876
54	Abnormality of molar morphology (HP:0011070)	1.76514018
55	Abnormality of molar (HP:0011077)	1.76514018
56	Ventricular fibrillation (HP:0001663)	1.75173619
57	Abnormality of the pupil (HP:0000615)	1.74634097
58	Abnormality of dental color (HP:0011073)	1.71950426
59	Widely patent fontanelles and sutures (HP:0004492)	1.71936900
60	Absent eyelashes (HP:0000561)	1.70096762
61	Fatigable weakness (HP:0003473)	1.69139132
62	Abnormality of the neuromuscular junction (HP:0003398)	1.69139132
63	Hyporeflexia of lower limbs (HP:0002600)	1.68054823
64	Focal dystonia (HP:0004373)	1.65474623
65	Recurrent corneal erosions (HP:0000495)	1.63992813
66	Unilateral renal agenesis (HP:0000122)	1.62022417
67	Blepharitis (HP:0000498)	1.58542683
68	Abnormality of the aortic arch (HP:0012303)	1.57329827
69	Abnormality of placental membranes (HP:0011409)	1.54810002
70	Amniotic constriction ring (HP:0009775)	1.54810002
71	Abnormality of the dental pulp (HP:0006479)	1.54351508
72	Lip pit (HP:0100267)	1.52469243
73	Type 1 muscle fiber predominance (HP:0003803)	1.51960681
74	Sudden death (HP:0001699)	1.51862378
75	Acanthosis nigricans (HP:0000956)	1.50519121
76	Round ear (HP:0100830)	1.49755094
77	Carious teeth (HP:0000670)	1.47537531
78	Hypergammaglobulinemia (HP:0010702)	1.46789671
79	Anonychia (HP:0001798)	1.43801545
80	Gangrene (HP:0100758)	1.43748083
81	Keratoconjunctivitis sicca (HP:0001097)	1.40421807
82	Atrophic scars (HP:0001075)	1.39966396
83	Ectropion (HP:0000656)	1.38705833
84	Laryngomalacia (HP:0001601)	1.36573997
85	Increased connective tissue (HP:0009025)	1.36008391
86	Distal lower limb muscle weakness (HP:0009053)	1.35530201
87	Craniofacial hyperostosis (HP:0004493)	1.34582074
88	Achilles tendon contracture (HP:0001771)	1.33302563
89	Heterogeneous (HP:0001425)	1.32935009
90	Abnormality of the fingernails (HP:0001231)	1.32531759
91	Autoamputation (HP:0001218)	1.30790146
92	Sparse scalp hair (HP:0002209)	1.24862121
93	Abnormality of the Achilles tendon (HP:0005109)	1.24415055
94	Hamartoma of the eye (HP:0010568)	1.24093073
95	Keratoconjunctivitis (HP:0001096)	1.23297164
96	Neonatal onset (HP:0003623)	1.20355036
97	Selective tooth agenesis (HP:0001592)	1.19547196
98	Widely spaced teeth (HP:0000687)	1.19357061
99	Corneal dystrophy (HP:0001131)	1.18113536
100	Lack of skin elasticity (HP:0100679)	1.17409058

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.25116605
2	EPHA2	4.02813437
3	MAPKAPK3	3.92811847
4	MAP3K6	3.66301024
5	ERN1	3.65247899
6	EPHB2	3.25615780
7	TAOK1	3.03254803
8	MAP3K3	2.76743525
9	TRIB3	2.62706540
10	LATS1	2.58689868
11	MAP3K2	2.40646652
12	PIK3CG	2.27188468
13	MAP3K11	2.17886416
14	TTN	2.12654052
15	RPS6KB2	1.94936397
16	EEF2K	1.75514430
17	EPHB1	1.64412509
18	LATS2	1.64002273
19	FGFR2	1.53503928
20	FGFR1	1.50592381
21	BCR	1.50399285
22	MAP2K6	1.49826904
23	OBSCN	1.32522586
24	MST1R	1.25413200
25	BMX	1.24062112
26	MAP3K1	1.23730060
27	CDK6	1.22672933
28	RIPK1	1.22491933
29	NME1	1.21248470
30	FGFR4	1.19965961
31	PDGFRA	1.16758070
32	FGFR3	1.15989876
33	MAP2K3	1.12963852
34	KSR2	1.11856259
35	MAPKAPK2	1.09582933
36	PKN2	1.00464040
37	MAP3K7	0.99897330
38	BLK	0.99279859
39	PBK	0.98298378
40	PTK6	0.96746394
41	LRRK2	0.95067035
42	MAP3K9	0.87590275
43	DDR2	0.84293137
44	SIK1	0.84076624
45	PTK2	0.82895667
46	DYRK1B	0.80442122
47	RPS6KA4	0.80396743
48	MAP2K4	0.77286427
49	PIM2	0.73174405
50	MET	0.71620249
51	MAP2K1	0.70667658
52	TRPM7	0.70592468
53	PRKD1	0.70358898
54	STK38	0.70136120
55	STK38L	0.67472361
56	PAK4	0.64403039
57	TYRO3	0.62396356
58	CDK19	0.62281587
59	MAP3K10	0.59528354
60	TESK1	0.59371561
61	PAK3	0.58527483
62	NTRK2	0.57333507
63	ERBB4	0.55322158
64	NEK1	0.54505883
65	PRKCI	0.53624083
66	PRKCH	0.50367399
67	PHKG1	0.48656400
68	PHKG2	0.48656400
69	MAP3K5	0.48614151
70	PAK2	0.48369744
71	ERBB2	0.48134526
72	EPHA3	0.47243545
73	RPS6KA1	0.46226544
74	GSK3A	0.45882125
75	RET	0.45426680
76	PAK6	0.44796231
77	MAPK12	0.43025143
78	JAK1	0.41986413
79	TGFBR1	0.41054570
80	TYK2	0.40843597
81	ICK	0.39666161
82	MST4	0.39374567
83	CSNK1E	0.38199138
84	ALK	0.36316848
85	MAP2K2	0.34465306
86	JAK2	0.29868517
87	TGFBR2	0.29103988
88	ERBB3	0.29022590
89	FYN	0.27739074
90	MAP3K8	0.27577798
91	MATK	0.26734571
92	LIMK1	0.26453528
93	CLK1	0.24649818
94	CSNK1A1	0.24007440
95	SRC	0.23407293
96	STK11	0.23144315
97	ILK	0.22546539
98	MTOR	0.22543407
99	STK24	0.21891843
100	PRKACG	0.21191044

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.52450491
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.47737576
3	Fatty acid elongation_Homo sapiens_hsa00062	3.23666026
4	Fat digestion and absorption_Homo sapiens_hsa04975	3.02569250
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.37450319
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.35810853
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.96237733
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.80069140
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.74678269
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.70672026
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.69480250
12	Melanogenesis_Homo sapiens_hsa04916	1.63114757
13	Axon guidance_Homo sapiens_hsa04360	1.56188759
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.49768210
15	Bladder cancer_Homo sapiens_hsa05219	1.39158126
16	Glioma_Homo sapiens_hsa05214	1.38063028
17	Hippo signaling pathway_Homo sapiens_hsa04390	1.38030719
18	Proteoglycans in cancer_Homo sapiens_hsa05205	1.34846330
19	Thyroid cancer_Homo sapiens_hsa05216	1.33756351
20	Histidine metabolism_Homo sapiens_hsa00340	1.33226716
21	Caffeine metabolism_Homo sapiens_hsa00232	1.32424635
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.26882251
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.26760195
24	Acute myeloid leukemia_Homo sapiens_hsa05221	1.24868051
25	Tight junction_Homo sapiens_hsa04530	1.24833852
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.20450117
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18814443
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.18755265
29	Adherens junction_Homo sapiens_hsa04520	1.16902209
30	Mineral absorption_Homo sapiens_hsa04978	1.16439894
31	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.14517831
32	ECM-receptor interaction_Homo sapiens_hsa04512	1.12363060
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.04787775
34	Pancreatic secretion_Homo sapiens_hsa04972	1.02551698
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.01083494
36	Long-term potentiation_Homo sapiens_hsa04720	0.99924712
37	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.93739831
38	Endometrial cancer_Homo sapiens_hsa05213	0.92268244
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.90212080
40	Tyrosine metabolism_Homo sapiens_hsa00350	0.90118438
41	Wnt signaling pathway_Homo sapiens_hsa04310	0.88600793
42	Amoebiasis_Homo sapiens_hsa05146	0.86853951
43	Non-small cell lung cancer_Homo sapiens_hsa05223	0.86759580
44	Long-term depression_Homo sapiens_hsa04730	0.83230850
45	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83179798
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.83142998
47	Pertussis_Homo sapiens_hsa05133	0.83082960
48	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.82864352
49	Ras signaling pathway_Homo sapiens_hsa04014	0.80711702
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74199788
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.73624945
52	Gastric acid secretion_Homo sapiens_hsa04971	0.71809947
53	MicroRNAs in cancer_Homo sapiens_hsa05206	0.71128455
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.70240458
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.69466771
56	Renin secretion_Homo sapiens_hsa04924	0.68804483
57	Phototransduction_Homo sapiens_hsa04744	0.68027877
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66509696
59	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.66326115
60	Protein digestion and absorption_Homo sapiens_hsa04974	0.65853867
61	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.64088285
62	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63797578
63	Insulin resistance_Homo sapiens_hsa04931	0.63626994
64	Focal adhesion_Homo sapiens_hsa04510	0.62520671
65	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60779091
66	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.58703156
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.58097612
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56934561
69	Hepatitis C_Homo sapiens_hsa05160	0.56139063
70	Gap junction_Homo sapiens_hsa04540	0.54292905
71	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.54027533
72	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.53957326
73	Platelet activation_Homo sapiens_hsa04611	0.53733664
74	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.52711775
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.52036639
76	Salmonella infection_Homo sapiens_hsa05132	0.50782092
77	Notch signaling pathway_Homo sapiens_hsa04330	0.50738851
78	Renal cell carcinoma_Homo sapiens_hsa05211	0.48795495
79	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48541683
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47862496
81	ErbB signaling pathway_Homo sapiens_hsa04012	0.47488682
82	Salivary secretion_Homo sapiens_hsa04970	0.45378908
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43483344
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42538784
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.42160284
86	Fatty acid degradation_Homo sapiens_hsa00071	0.41605826
87	Insulin signaling pathway_Homo sapiens_hsa04910	0.41308403
88	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.41131264
89	p53 signaling pathway_Homo sapiens_hsa04115	0.40856454
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40455969
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40180400
92	Toxoplasmosis_Homo sapiens_hsa05145	0.38766964
93	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.38557714
94	Tuberculosis_Homo sapiens_hsa05152	0.37363500
95	Butanoate metabolism_Homo sapiens_hsa00650	0.37123240
96	Melanoma_Homo sapiens_hsa05218	0.35943248
97	Prion diseases_Homo sapiens_hsa05020	0.34806257
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34801564
99	Olfactory transduction_Homo sapiens_hsa04740	0.34515258
100	Pathways in cancer_Homo sapiens_hsa05200	0.34408075

KRTAP5-5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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