ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neuronal action potential propagation (GO:0019227)	6.32404940
2	snRNA transcription (GO:0009301)	5.23033721
3	histone H4-K12 acetylation (GO:0043983)	5.15312531
4	gamma-aminobutyric acid transport (GO:0015812)	4.89331491
5	intermediate filament organization (GO:0045109)	4.86372398
6	serotonin metabolic process (GO:0042428)	4.75314738
7	neuronal action potential (GO:0019228)	4.58667625
8	keratinocyte development (GO:0003334)	4.57181835
9	primary amino compound metabolic process (GO:1901160)	4.54271151
10	early endosome to late endosome transport (GO:0045022)	4.38535979
11	detection of light stimulus involved in visual perception (GO:0050908)	4.18504997
12	detection of light stimulus involved in sensory perception (GO:0050962)	4.18504997
13	protein targeting to vacuole (GO:0006623)	4.09934708
14	protein targeting to lysosome (GO:0006622)	4.09934708
15	establishment of protein localization to vacuole (GO:0072666)	4.09934708
16	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	3.87440148
17	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	3.87440148
18	heparin metabolic process (GO:0030202)	3.76379994
19	heparin biosynthetic process (GO:0030210)	3.76379994
20	piRNA metabolic process (GO:0034587)	3.75902452
21	phosphorelay signal transduction system (GO:0000160)	3.67196263
22	negative regulation of T cell differentiation in thymus (GO:0033085)	3.60282045
23	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.53796386
24	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.52780430
25	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.45320223
26	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.44308017
27	positive regulation of action potential (GO:0045760)	3.43318319
28	cellular ketone body metabolic process (GO:0046950)	3.40887089
29	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.40192739
30	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.40192739
31	heme transport (GO:0015886)	3.39825981
32	regulation of gene silencing by RNA (GO:0060966)	3.39431547
33	regulation of posttranscriptional gene silencing (GO:0060147)	3.39431547
34	regulation of gene silencing by miRNA (GO:0060964)	3.39431547
35	neurotransmitter-gated ion channel clustering (GO:0072578)	3.31072492
36	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.29012142
37	phenol-containing compound catabolic process (GO:0019336)	3.28054956
38	fatty acid elongation (GO:0030497)	3.26868859
39	protein localization to lysosome (GO:0061462)	3.25424512
40	protein localization to vacuole (GO:0072665)	3.25424512
41	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.25122687
42	L-phenylalanine catabolic process (GO:0006559)	3.25122687
43	hair follicle morphogenesis (GO:0031069)	3.23992126
44	membrane depolarization during action potential (GO:0086010)	3.23503009
45	intermediate filament cytoskeleton organization (GO:0045104)	3.18528282
46	flavonoid metabolic process (GO:0009812)	3.18288009
47	regulation of axon regeneration (GO:0048679)	3.15744501
48	regulation of neuron projection regeneration (GO:0070570)	3.15744501
49	endoderm formation (GO:0001706)	3.15608448
50	cellular response to ATP (GO:0071318)	3.11394637
51	intermediate filament-based process (GO:0045103)	3.06912932
52	behavioral response to nicotine (GO:0035095)	3.06669263
53	neuron remodeling (GO:0016322)	3.05001053
54	ketone body metabolic process (GO:1902224)	2.98750760
55	positive regulation of protein homodimerization activity (GO:0090073)	2.97460960
56	positive regulation of mRNA catabolic process (GO:0061014)	2.97316430
57	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.94668388
58	phenylpropanoid metabolic process (GO:0009698)	2.94364255
59	protein localization to synapse (GO:0035418)	2.92407484
60	positive regulation of synapse assembly (GO:0051965)	2.91010350
61	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.89801245
62	action potential (GO:0001508)	2.81551201
63	brain morphogenesis (GO:0048854)	2.81344234
64	glutamate receptor signaling pathway (GO:0007215)	2.80248307
65	cardiovascular system development (GO:0072358)	2.79550611
66	regulation of action potential (GO:0098900)	2.78237645
67	Sertoli cell development (GO:0060009)	2.76293310
68	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.73882381
69	keratinization (GO:0031424)	2.71650956
70	tyrosine metabolic process (GO:0006570)	2.70985566
71	indole-containing compound metabolic process (GO:0042430)	2.68588733
72	protein K48-linked deubiquitination (GO:0071108)	2.68085107
73	regulation of hexokinase activity (GO:1903299)	2.67365669
74	regulation of glucokinase activity (GO:0033131)	2.67365669
75	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.67031980
76	regulation of dopamine metabolic process (GO:0042053)	2.66306214
77	regulation of catecholamine metabolic process (GO:0042069)	2.66306214
78	cell differentiation in hindbrain (GO:0021533)	2.64255444
79	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.63464484
80	somite rostral/caudal axis specification (GO:0032525)	2.62494160
81	regulation of mRNA catabolic process (GO:0061013)	2.56669856
82	presynaptic membrane assembly (GO:0097105)	2.56176088
83	adult walking behavior (GO:0007628)	2.55889824
84	magnesium ion transport (GO:0015693)	2.55728316
85	positive regulation of mitochondrial fission (GO:0090141)	2.55503418
86	cerebellar granule cell differentiation (GO:0021707)	2.54985476
87	response to acidic pH (GO:0010447)	2.53864281
88	negative regulation of keratinocyte proliferation (GO:0010839)	2.53641298
89	positive regulation of dendrite morphogenesis (GO:0050775)	2.52021623
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.51614687
91	L-phenylalanine metabolic process (GO:0006558)	2.51614687
92	negative regulation of execution phase of apoptosis (GO:1900118)	2.51011296
93	behavioral response to ethanol (GO:0048149)	2.50697060
94	aromatic amino acid family catabolic process (GO:0009074)	2.49866358
95	interkinetic nuclear migration (GO:0022027)	2.49199333
96	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.49011563
97	protein carboxylation (GO:0018214)	2.48889301
98	peptidyl-glutamic acid carboxylation (GO:0017187)	2.48889301
99	molting cycle (GO:0042303)	11.7561587
100	hair cycle (GO:0042633)	11.7561587

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.11768120
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.38818837
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.73070667
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.07893979
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82136161
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.40010022
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23632336
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.10334407
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09832414
10	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.03419223
11	VDR_22108803_ChIP-Seq_LS180_Human	1.84917190
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.80945528
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.80159637
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79082487
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77020823
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74566105
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.73965155
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73839224
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71711614
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.69760427
21	AR_25329375_ChIP-Seq_VCAP_Human	1.67473333
22	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.65997450
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65671147
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.61721466
25	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.58269723
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.57388620
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56233888
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54442285
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54442285
30	AR_21572438_ChIP-Seq_LNCaP_Human	1.52034486
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.49588519
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47563310
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.46958110
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.46287176
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.44048391
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42873293
37	EWS_26573619_Chip-Seq_HEK293_Human	1.42633867
38	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42157501
39	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.42074327
40	STAT3_23295773_ChIP-Seq_U87_Human	1.40073886
41	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40041008
42	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.36108520
43	FUS_26573619_Chip-Seq_HEK293_Human	1.35796119
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35048307
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34563578
46	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.31016945
47	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.30655655
48	DROSHA_22980978_ChIP-Seq_HELA_Human	1.29441613
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26961051
50	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.26665970
51	P300_19829295_ChIP-Seq_ESCs_Human	1.25431153
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25227184
53	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24992353
54	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.24881297
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.20058846
56	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19834190
57	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19252456
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.18649109
59	TCF4_23295773_ChIP-Seq_U87_Human	1.17507006
60	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.17286635
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.16150599
62	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.16150599
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15793554
64	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.15062685
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14342604
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13668741
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.12575274
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.11620964
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11511579
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11246298
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11222542
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09617357
73	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.06901549
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06546558
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04772015
76	TAF15_26573619_Chip-Seq_HEK293_Human	1.02096332
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00530247
78	KDM2B_26808549_Chip-Seq_REH_Human	1.00324243
79	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99266294
80	RXR_22108803_ChIP-Seq_LS180_Human	0.98958765
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.98936049
82	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97440056
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.94677246
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94554232
85	TP63_23658742_ChIP-Seq_EP156T_Human	0.94391624
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.94044257
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93503059
88	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93275283
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93019951
90	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93019951
91	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92059150
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.90706146
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89723740
94	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89633460
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89633460
96	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.89419246
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.89400331
98	ERA_21632823_ChIP-Seq_H3396_Human	0.88991889
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.88329965
100	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.87401287

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	6.28796999
2	MP0004147_increased_porphyrin_level	5.44356841
3	MP0000647_abnormal_sebaceous_gland	3.95099563
4	MP0004270_analgesia	3.80811019
5	MP0008877_abnormal_DNA_methylation	2.99294680
6	MP0002098_abnormal_vibrissa_morphology	2.58887413
7	MP0005423_abnormal_somatic_nervous	2.54964969
8	MP0000579_abnormal_nail_morphology	2.49007603
9	MP0005646_abnormal_pituitary_gland	2.46226071
10	MP0009046_muscle_twitch	2.33520890
11	MP0000427_abnormal_hair_cycle	2.24399013
12	MP0001968_abnormal_touch/_nociception	2.15030278
13	MP0009745_abnormal_behavioral_response	2.13897958
14	MP0003635_abnormal_synaptic_transmissio	2.00564649
15	MP0005085_abnormal_gallbladder_physiolo	2.00363310
16	MP0004885_abnormal_endolymph	1.96510759
17	MP0002734_abnormal_mechanical_nocicepti	1.95207498
18	MP0002837_dystrophic_cardiac_calcinosis	1.86398940
19	MP0002064_seizures	1.80725691
20	MP0000569_abnormal_digit_pigmentation	1.79190347
21	MP0003890_abnormal_embryonic-extraembry	1.78706920
22	MP0005379_endocrine/exocrine_gland_phen	1.78246010
23	MP0002733_abnormal_thermal_nociception	1.78165355
24	MP0002796_impaired_skin_barrier	1.77960077
25	MP0000377_abnormal_hair_follicle	1.76392226
26	MP0005275_abnormal_skin_tensile	1.70074271
27	MP0003787_abnormal_imprinting	1.69667908
28	MP0005551_abnormal_eye_electrophysiolog	1.67109447
29	MP0000383_abnormal_hair_follicle	1.62151244
30	MP0000631_abnormal_neuroendocrine_gland	1.58913664
31	MP0002572_abnormal_emotion/affect_behav	1.58330040
32	MP0005645_abnormal_hypothalamus_physiol	1.57382615
33	MP0005647_abnormal_sex_gland	1.53934929
34	MP0005083_abnormal_biliary_tract	1.53577825
35	MP0002272_abnormal_nervous_system	1.50888061
36	MP0002163_abnormal_gland_morphology	1.37812457
37	MP0003122_maternal_imprinting	1.37733276
38	MP0010678_abnormal_skin_adnexa	1.37061894
39	MP0002736_abnormal_nociception_after	1.35161323
40	MP0003646_muscle_fatigue	1.34972674
41	MP0001486_abnormal_startle_reflex	1.34947564
42	MP0004381_abnormal_hair_follicle	1.33061884
43	MP0001970_abnormal_pain_threshold	1.32247273
44	MP0001905_abnormal_dopamine_level	1.30577641
45	MP0004133_heterotaxia	1.27489413
46	MP0002557_abnormal_social/conspecific_i	1.27421820
47	MP0001485_abnormal_pinna_reflex	1.26731734
48	MP0002067_abnormal_sensory_capabilities	1.24704486
49	MP0001986_abnormal_taste_sensitivity	1.22061982
50	MP0001501_abnormal_sleep_pattern	1.19081822
51	MP0005377_hearing/vestibular/ear_phenot	1.18633473
52	MP0003878_abnormal_ear_physiology	1.18633473
53	MP0002735_abnormal_chemical_nociception	1.17941802
54	MP0005075_abnormal_melanosome_morpholog	1.15366501
55	MP0010234_abnormal_vibrissa_follicle	1.14965579
56	MP0008875_abnormal_xenobiotic_pharmacok	1.14896880
57	MP0010329_abnormal_lipoprotein_level	1.13491676
58	MP0005386_behavior/neurological_phenoty	1.12750195
59	MP0004924_abnormal_behavior	1.12750195
60	MP0002063_abnormal_learning/memory/cond	1.12507157
61	MP0008057_abnormal_DNA_replication	1.11890643
62	MP0003633_abnormal_nervous_system	1.11014878
63	MP0008872_abnormal_physiological_respon	1.10228349
64	MP0002822_catalepsy	1.06465355
65	MP0000367_abnormal_coat/_hair	1.06433319
66	MP0006276_abnormal_autonomic_nervous	0.98857653
67	MP0002090_abnormal_vision	0.98078727
68	MP0004859_abnormal_synaptic_plasticity	0.97780135
69	MP0010386_abnormal_urinary_bladder	0.96287104
70	MP0002139_abnormal_hepatobiliary_system	0.94941964
71	MP0005187_abnormal_penis_morphology	0.94546135
72	MP0005360_urolithiasis	0.94298508
73	MP0005501_abnormal_skin_physiology	0.93888720
74	MP0003698_abnormal_male_reproductive	0.92725353
75	MP0002138_abnormal_hepatobiliary_system	0.91752588
76	MP0003631_nervous_system_phenotype	0.91376447
77	MP0010771_integument_phenotype	0.91166471
78	MP0005332_abnormal_amino_acid	0.90101159
79	MP0006292_abnormal_olfactory_placode	0.88178309
80	MP0004742_abnormal_vestibular_system	0.86623343
81	MP0002693_abnormal_pancreas_physiology	0.86382525
82	MP0003195_calcinosis	0.82668530
83	MP0005448_abnormal_energy_balance	0.82332320
84	MP0002089_abnormal_postnatal_growth/wei	0.80899090
85	MP0004019_abnormal_vitamin_homeostasis	0.77110986
86	MP0002210_abnormal_sex_determination	0.75967677
87	MP0010368_abnormal_lymphatic_system	0.75756840
88	MP0005174_abnormal_tail_pigmentation	0.75500021
89	MP0005409_darkened_coat_color	0.74926607
90	MP0005410_abnormal_fertilization	0.73753883
91	MP0005365_abnormal_bile_salt	0.71798174
92	MP0002069_abnormal_eating/drinking_beha	0.71713926
93	MP0005389_reproductive_system_phenotype	0.71403201
94	MP0005084_abnormal_gallbladder_morpholo	0.69336864
95	MP0004142_abnormal_muscle_tone	0.68774637
96	MP0000778_abnormal_nervous_system	0.68664909
97	MP0001944_abnormal_pancreas_morphology	0.67966717
98	MP0000653_abnormal_sex_gland	0.64997477
99	MP0008961_abnormal_basal_metabolism	0.64880224
100	MP0002909_abnormal_adrenal_gland	0.64284275

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	5.81852110
2	Hyperventilation (HP:0002883)	4.82299981
3	Woolly hair (HP:0002224)	4.61100758
4	Brittle hair (HP:0002299)	4.60701318
5	Slow-growing hair (HP:0002217)	4.44439971
6	Abnormality of hair growth rate (HP:0011363)	4.44439971
7	Onycholysis (HP:0001806)	4.23279320
8	Gaze-evoked nystagmus (HP:0000640)	4.04671549
9	Abnormal hair laboratory examination (HP:0003328)	4.03886449
10	Hypotrichosis (HP:0001006)	3.78335975
11	Fair hair (HP:0002286)	3.48584111
12	Prolonged partial thromboplastin time (HP:0003645)	3.41307845
13	Medial flaring of the eyebrow (HP:0010747)	3.38827068
14	Vascular calcification (HP:0004934)	3.26798351
15	Abnormality of the axillary hair (HP:0100134)	3.22424125
16	Abnormality of secondary sexual hair (HP:0009888)	3.22424125
17	Prominent supraorbital ridges (HP:0000336)	3.21959098
18	Generalized myoclonic seizures (HP:0002123)	3.17953429
19	Autoamputation (HP:0001218)	3.17247973
20	Protruding tongue (HP:0010808)	3.09221722
21	Mesangial abnormality (HP:0001966)	3.07736847
22	Tubular atrophy (HP:0000092)	3.05193908
23	Inability to walk (HP:0002540)	3.02772542
24	Nephrogenic diabetes insipidus (HP:0009806)	2.98048447
25	Absent hair (HP:0002298)	2.96642191
26	Focal motor seizures (HP:0011153)	2.93882796
27	Broad-based gait (HP:0002136)	2.88919068
28	Mitral stenosis (HP:0001718)	2.87330707
29	Congenital, generalized hypertrichosis (HP:0004540)	2.82051057
30	Gait imbalance (HP:0002141)	2.81463091
31	Generalized hypopigmentation of hair (HP:0011358)	2.80045629
32	Cardiovascular calcification (HP:0011915)	2.78830218
33	Arthropathy (HP:0003040)	2.78557784
34	Absent eyebrow (HP:0002223)	2.76082252
35	Inappropriate behavior (HP:0000719)	2.70539675
36	Fine hair (HP:0002213)	2.69756897
37	Congenital primary aphakia (HP:0007707)	2.63827724
38	Bilateral sensorineural hearing impairment (HP:0008619)	2.62952371
39	Akinesia (HP:0002304)	2.62238447
40	Hemiparesis (HP:0001269)	2.55916691
41	Curly hair (HP:0002212)	2.53153549
42	Thick nail (HP:0001805)	2.48486311
43	Osteomalacia (HP:0002749)	2.47676000
44	Clumsiness (HP:0002312)	2.47675868
45	Pancreatic cysts (HP:0001737)	2.46704041
46	Furrowed tongue (HP:0000221)	2.46428993
47	Enlarged penis (HP:0000040)	2.46022816
48	Type II lissencephaly (HP:0007260)	2.44264304
49	Concave nail (HP:0001598)	2.43899083
50	Vacuolated lymphocytes (HP:0001922)	2.31352411
51	Drooling (HP:0002307)	2.31261722
52	Pancreatic fibrosis (HP:0100732)	2.29904478
53	Oligomenorrhea (HP:0000876)	2.24212600
54	Limb dystonia (HP:0002451)	2.23299550
55	Ventricular fibrillation (HP:0001663)	2.21233864
56	Dry hair (HP:0011359)	2.19190508
57	Joint hemorrhage (HP:0005261)	2.17843112
58	Conjunctival hamartoma (HP:0100780)	2.13124707
59	Nephronophthisis (HP:0000090)	2.12610850
60	Excessive salivation (HP:0003781)	2.12228896
61	Focal seizures (HP:0007359)	2.12024272
62	Febrile seizures (HP:0002373)	2.10515301
63	Poor coordination (HP:0002370)	2.08589040
64	True hermaphroditism (HP:0010459)	2.08003220
65	Palmar hyperkeratosis (HP:0010765)	2.07832521
66	Back pain (HP:0003418)	2.04547299
67	Large for gestational age (HP:0001520)	2.03521331
68	Congenital sensorineural hearing impairment (HP:0008527)	2.01926286
69	Palmoplantar hyperkeratosis (HP:0000972)	2.01704862
70	Abnormality of the renal medulla (HP:0100957)	2.00528564
71	Absent eyelashes (HP:0000561)	2.00265020
72	Abnormality of dental color (HP:0011073)	1.99953586
73	Attenuation of retinal blood vessels (HP:0007843)	1.99485810
74	Flat occiput (HP:0005469)	1.98347157
75	Epileptic encephalopathy (HP:0200134)	1.98049700
76	Follicular hyperkeratosis (HP:0007502)	1.97422391
77	Agitation (HP:0000713)	1.97284726
78	Amblyopia (HP:0000646)	1.95512901
79	Abnormality of the dental pulp (HP:0006479)	1.94031090
80	Lissencephaly (HP:0001339)	1.92582998
81	Hypothermia (HP:0002045)	1.91963274
82	Tinnitus (HP:0000360)	1.91862118
83	Abnormality of the sella turcica (HP:0002679)	1.91586511
84	Slender build (HP:0001533)	1.91366940
85	Genital tract atresia (HP:0001827)	1.90501128
86	Generalized tonic-clonic seizures (HP:0002069)	1.89200648
87	Vaginal atresia (HP:0000148)	1.87530880
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.86861725
89	Nail dystrophy (HP:0008404)	1.86389508
90	Genetic anticipation (HP:0003743)	1.85273644
91	Tapered finger (HP:0001182)	1.84921772
92	Conjugated hyperbilirubinemia (HP:0002908)	1.84541720
93	Blue irides (HP:0000635)	1.81058967
94	Macroglossia (HP:0000158)	1.78190330
95	Amelogenesis imperfecta (HP:0000705)	1.77913834
96	Exotropia (HP:0000577)	1.76031368
97	Left ventricular hypertrophy (HP:0001712)	1.73065436
98	Hypsarrhythmia (HP:0002521)	1.71623551
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.71575185
100	Hamartoma of the eye (HP:0010568)	1.71122477

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.10697186
2	MAP3K4	4.57099553
3	EPHA4	4.12201370
4	ACVR1B	3.79336450
5	PHKG2	3.00571845
6	PHKG1	3.00571845
7	TNIK	2.94591678
8	CASK	2.20296220
9	SIK2	1.97127186
10	GRK1	1.95956915
11	STK24	1.90751755
12	BMPR1B	1.86484102
13	ZAK	1.83256140
14	TLK1	1.74521909
15	ADRBK2	1.69415789
16	FGFR2	1.68159736
17	IRAK2	1.65371267
18	MAP2K7	1.58123087
19	TAOK1	1.57515552
20	PTK2B	1.56713357
21	MAPKAPK3	1.51149372
22	CSNK1G3	1.45582522
23	CSNK1G2	1.44059990
24	DAPK2	1.43627528
25	MAPK13	1.43503794
26	STK38L	1.35741965
27	CSNK1G1	1.34051095
28	MAP3K6	1.32412784
29	ADRBK1	1.27044678
30	CSNK1A1L	1.24670473
31	NLK	1.24648036
32	STK3	1.21397508
33	NTRK3	1.17074919
34	MST4	1.13201324
35	EEF2K	1.13019554
36	NTRK2	1.11726505
37	PNCK	1.08341723
38	FGR	1.05819092
39	PRKCE	1.02953331
40	TGFBR1	0.99238223
41	TAOK3	0.98604650
42	SIK1	0.97777157
43	PRKAA2	0.96840001
44	OXSR1	0.93666529
45	MARK1	0.89065059
46	STK11	0.87497278
47	MAP3K9	0.82373641
48	MAP2K4	0.77454011
49	PRKCG	0.76903216
50	INSRR	0.75386753
51	SGK2	0.71008486
52	STK38	0.70528775
53	NEK2	0.67483514
54	CAMK1G	0.67293545
55	IRAK1	0.65552307
56	CSNK1D	0.63717054
57	CHUK	0.63325210
58	STK39	0.61395612
59	PAK3	0.59983299
60	IKBKB	0.59415516
61	TRPM7	0.58759384
62	MAP2K1	0.58333749
63	MKNK2	0.57406681
64	PRKG2	0.57222525
65	MAP4K2	0.53587839
66	TYRO3	0.52834754
67	PKN1	0.52521072
68	PIM1	0.52383936
69	FGFR3	0.49617579
70	MAP3K13	0.46881654
71	CAMK2A	0.45358576
72	PLK2	0.44736939
73	SGK223	0.43509002
74	SGK494	0.43509002
75	NTRK1	0.43497672
76	ERBB2	0.43149540
77	PRKAA1	0.42732979
78	RPS6KB1	0.40859642
79	PIK3CA	0.39718925
80	RPS6KA2	0.38256017
81	MAPKAPK5	0.37481226
82	PRKCI	0.36311672
83	RPS6KA6	0.35469435
84	FES	0.35094760
85	CDK5	0.34475863
86	CSNK1E	0.34180753
87	PINK1	0.32073673
88	PRKCQ	0.31929906
89	MAP2K2	0.30931095
90	PRKACA	0.30851400
91	CAMK1D	0.29324433
92	PRKD1	0.27819986
93	NUAK1	0.27272067
94	MAP3K7	0.25919753
95	GRK5	0.25478159
96	MATK	0.25275008
97	CAMK2B	0.24399593
98	SGK3	0.24265114
99	CSNK1A1	0.23234140
100	SGK1	0.22053447

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.97394020
2	Phototransduction_Homo sapiens_hsa04744	2.96022927
3	Nicotine addiction_Homo sapiens_hsa05033	2.81643272
4	Phenylalanine metabolism_Homo sapiens_hsa00360	2.67929675
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.55063379
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.37793983
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.20954113
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.10216992
9	Long-term depression_Homo sapiens_hsa04730	2.05370475
10	Dopaminergic synapse_Homo sapiens_hsa04728	1.95606480
11	Circadian entrainment_Homo sapiens_hsa04713	1.88278509
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86817888
13	Amphetamine addiction_Homo sapiens_hsa05031	1.84748557
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.78675806
15	Cocaine addiction_Homo sapiens_hsa05030	1.77043636
16	Tyrosine metabolism_Homo sapiens_hsa00350	1.75476698
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.65776173
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.60689396
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.59371693
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.56976363
21	Olfactory transduction_Homo sapiens_hsa04740	1.55495362
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53216798
23	Arginine biosynthesis_Homo sapiens_hsa00220	1.51227368
24	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.43478857
25	Sphingolipid metabolism_Homo sapiens_hsa00600	1.42142340
26	Histidine metabolism_Homo sapiens_hsa00340	1.40658561
27	Serotonergic synapse_Homo sapiens_hsa04726	1.36277661
28	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.27472627
29	Morphine addiction_Homo sapiens_hsa05032	1.26971921
30	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.24757805
31	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.24602519
32	Taste transduction_Homo sapiens_hsa04742	1.24134821
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.23854890
34	Salivary secretion_Homo sapiens_hsa04970	1.18588472
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.18420147
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.17350181
37	Sulfur relay system_Homo sapiens_hsa04122	1.16679516
38	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15566964
39	Gastric acid secretion_Homo sapiens_hsa04971	1.15517201
40	Insulin secretion_Homo sapiens_hsa04911	1.13912656
41	ABC transporters_Homo sapiens_hsa02010	1.13195422
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13078596
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12641933
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.12361496
45	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.10789056
46	Butanoate metabolism_Homo sapiens_hsa00650	1.10359165
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.09631006
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08489282
49	Retinol metabolism_Homo sapiens_hsa00830	1.06880843
50	Renin secretion_Homo sapiens_hsa04924	1.05318252
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05086446
52	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.03681199
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03358196
54	GABAergic synapse_Homo sapiens_hsa04727	1.01373966
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00770034
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95003944
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.91802435
58	Bile secretion_Homo sapiens_hsa04976	0.86901784
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86354795
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.84327384
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84154622
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.79149547
63	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.75691268
64	Cholinergic synapse_Homo sapiens_hsa04725	0.74476570
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.74205990
66	Fatty acid elongation_Homo sapiens_hsa00062	0.74026104
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.71414158
68	Complement and coagulation cascades_Homo sapiens_hsa04610	0.70505429
69	MAPK signaling pathway_Homo sapiens_hsa04010	0.69171173
70	Axon guidance_Homo sapiens_hsa04360	0.67309930
71	Long-term potentiation_Homo sapiens_hsa04720	0.66547418
72	GnRH signaling pathway_Homo sapiens_hsa04912	0.62830408
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.58256460
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57468842
75	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.55985618
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54428033
77	Asthma_Homo sapiens_hsa05310	0.54179810
78	Pancreatic secretion_Homo sapiens_hsa04972	0.54045734
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.53077260
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.52568056
81	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52336787
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51319603
83	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.50049909
84	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48903242
85	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48829061
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.48600868
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.48339215
88	Ras signaling pathway_Homo sapiens_hsa04014	0.48184147
89	VEGF signaling pathway_Homo sapiens_hsa04370	0.48066468
90	Mineral absorption_Homo sapiens_hsa04978	0.45546875
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.43738852
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43706235
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.40628810
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38877433
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.36594940
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.36382080
97	Choline metabolism in cancer_Homo sapiens_hsa05231	0.36364524
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35302820
99	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.34971918
100	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.34653393

KRTAP5-7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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