ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	8.66883897
2	peptide cross-linking (GO:0018149)	8.64438740
3	adhesion of symbiont to host (GO:0044406)	8.49030559
4	hair follicle morphogenesis (GO:0031069)	8.20737389
5	intermediate filament cytoskeleton organization (GO:0045104)	7.06485663
6	intermediate filament-based process (GO:0045103)	6.83907084
7	epidermis development (GO:0008544)	6.39499612
8	cell wall macromolecule metabolic process (GO:0044036)	6.34957402
9	cell wall macromolecule catabolic process (GO:0016998)	6.34957402
10	keratinocyte differentiation (GO:0030216)	6.07724252
11	establishment of skin barrier (GO:0061436)	5.88872310
12	citrulline metabolic process (GO:0000052)	5.72978403
13	hair cycle process (GO:0022405)	5.45595223
14	molting cycle process (GO:0022404)	5.45595223
15	hemidesmosome assembly (GO:0031581)	5.41110485
16	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.32660867
17	regulation of water loss via skin (GO:0033561)	5.22849134
18	peptidyl-arginine modification (GO:0018195)	4.80177130
19	skin morphogenesis (GO:0043589)	4.75953240
20	epidermal cell differentiation (GO:0009913)	4.73615319
21	molting cycle (GO:0042303)	34.3084985
22	hair cycle (GO:0042633)	34.3084985
23	keratinocyte development (GO:0003334)	3.89833476
24	tooth mineralization (GO:0034505)	3.75254302
25	multicellular organismal water homeostasis (GO:0050891)	3.51364345
26	negative regulation of keratinocyte proliferation (GO:0010839)	3.49470728
27	hair follicle development (GO:0001942)	3.42138759
28	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.34274990
29	regulation of keratinocyte differentiation (GO:0045616)	3.30326424
30	positive regulation of hair follicle development (GO:0051798)	3.26077967
31	positive regulation of hair cycle (GO:0042635)	3.26077967
32	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.24729237
33	ectoderm development (GO:0007398)	3.20041492
34	regulation of hair follicle development (GO:0051797)	3.07044799
35	gap junction assembly (GO:0016264)	3.04970101
36	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.03645829
37	epithelium development (GO:0060429)	3.02806689
38	bone trabecula formation (GO:0060346)	2.97584598
39	water homeostasis (GO:0030104)	2.86959766
40	regulation of hair cycle (GO:0042634)	2.83973677
41	fatty acid elongation (GO:0030497)	2.83006282
42	positive regulation of meiotic cell cycle (GO:0051446)	2.77043890
43	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.75898644
44	positive regulation of epidermis development (GO:0045684)	2.75712005
45	negative regulation of protein localization to plasma membrane (GO:1903077)	2.69549317
46	atrioventricular valve morphogenesis (GO:0003181)	2.59736150
47	regulation of epidermal cell differentiation (GO:0045604)	2.57156584
48	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.55758011
49	regulation of epidermis development (GO:0045682)	2.48825345
50	ventricular cardiac muscle cell action potential (GO:0086005)	2.40792109
51	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.31690207
52	negative regulation of cell fate specification (GO:0009996)	2.30715299
53	positive regulation of epidermal cell differentiation (GO:0045606)	2.27818594
54	phosphatidylserine metabolic process (GO:0006658)	2.27458773
55	wound healing, spreading of epidermal cells (GO:0035313)	2.26279324
56	cranial suture morphogenesis (GO:0060363)	2.25524162
57	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.23922679
58	positive regulation of monocyte chemotaxis (GO:0090026)	2.23898756
59	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.16715912
60	skin development (GO:0043588)	2.16432405
61	negative regulation of epidermis development (GO:0045683)	2.02712747
62	regulation of cardioblast differentiation (GO:0051890)	2.02130496
63	lymph vessel development (GO:0001945)	2.01844962
64	regulation of heart rate by cardiac conduction (GO:0086091)	2.01745536
65	aging (GO:0007568)	2.01110060
66	intermediate filament organization (GO:0045109)	12.5124773
67	keratinization (GO:0031424)	12.0377900
68	desmosome organization (GO:0002934)	10.5810250
69	adhesion of symbiont to host cell (GO:0044650)	10.0755517
70	virion attachment to host cell (GO:0019062)	10.0755517
71	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.99683045
72	epithelial cell-cell adhesion (GO:0090136)	1.98385245
73	regulation of ruffle assembly (GO:1900027)	1.97275379
74	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.96909987
75	regulation of keratinocyte proliferation (GO:0010837)	1.96248874
76	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.93263928
77	cell-substrate junction assembly (GO:0007044)	1.92119551
78	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.91623106
79	outflow tract septum morphogenesis (GO:0003148)	1.91605321
80	cell communication involved in cardiac conduction (GO:0086065)	1.91510136
81	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.84445895
82	non-canonical Wnt signaling pathway (GO:0035567)	1.82412947
83	myotube differentiation (GO:0014902)	1.81045773
84	ephrin receptor signaling pathway (GO:0048013)	1.80947274
85	very long-chain fatty acid metabolic process (GO:0000038)	1.73849956
86	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.69785114
87	establishment of planar polarity (GO:0001736)	1.67808428
88	establishment of tissue polarity (GO:0007164)	1.67808428
89	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.67163391
90	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.67163391
91	alditol phosphate metabolic process (GO:0052646)	1.66948884
92	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.66821890
93	keratinocyte proliferation (GO:0043616)	1.66374435
94	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.62917375
95	negative regulation of epidermal cell differentiation (GO:0045605)	1.61881313
96	primary alcohol catabolic process (GO:0034310)	1.61252170
97	craniofacial suture morphogenesis (GO:0097094)	1.61102546
98	regulation of monocyte chemotaxis (GO:0090025)	1.59169732
99	wound healing, spreading of cells (GO:0044319)	1.57335945
100	eyelid development in camera-type eye (GO:0061029)	1.57220497

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.69998633
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.93269660
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.64227660
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.99687559
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.26858013
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.09136359
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.01465599
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	13.3740434
9	EGR1_19032775_ChIP-ChIP_M12_Human	1.83639119
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.82223353
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.81240239
12	TAF2_19829295_ChIP-Seq_ESCs_Human	1.80946467
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.74084785
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.71356553
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.70481876
16	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.68391133
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.68289226
18	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.67995958
19	ERG_20517297_ChIP-Seq_VCAP_Human	1.63933282
20	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.61890619
21	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.61890619
22	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.59052588
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.50788651
24	TP63_22573176_ChIP-Seq_HFKS_Human	1.46670468
25	RACK7_27058665_Chip-Seq_MCF-7_Human	1.46291650
26	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.45814477
27	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.45786600
28	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.45731717
29	BCL6_27268052_Chip-Seq_Bcells_Human	1.43861426
30	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.42362979
31	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.41212011
32	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.39712602
33	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.39374189
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38134652
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.36303039
36	LXR_22292898_ChIP-Seq_THP-1_Human	1.36259647
37	ATF3_27146783_Chip-Seq_COLON_Human	1.35935983
38	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.32591805
39	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27962027
40	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.27212914
41	AHR_22903824_ChIP-Seq_MCF-7_Human	1.25491359
42	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.22385117
43	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.22012903
44	CEBPB_22108803_ChIP-Seq_LS180_Human	1.18558640
45	PHF8_20622854_ChIP-Seq_HELA_Human	1.18516613
46	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17140140
47	TP63_23658742_ChIP-Seq_EP156T_Human	1.16989431
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.15842235
49	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14824119
50	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.14777526
51	P68_20966046_ChIP-Seq_HELA_Human	1.14276941
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12593387
53	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.12245838
54	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.11063786
55	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.07854654
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.07725034
57	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07149695
58	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05351242
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04588230
60	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.03267291
61	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.02724345
62	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02146291
63	SMC4_20622854_ChIP-Seq_HELA_Human	1.01084563
64	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00886875
65	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.00313005
66	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.98691853
67	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.98541145
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98230254
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98208614
70	SPI1_20517297_ChIP-Seq_HL60_Human	0.96415207
71	SOX2_21211035_ChIP-Seq_LN229_Human	0.94953656
72	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.94688219
73	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93328377
74	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92896384
75	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.92451252
76	* E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91083264
77	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.90511226
78	RXR_22108803_ChIP-Seq_LS180_Human	0.89632741
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.88933297
80	SOX2_20726797_ChIP-Seq_SW620_Human	0.86921187
81	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86858560
82	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86725972
83	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.85471319
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.84784876
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84130967
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.84104633
87	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.83336563
88	AR_21572438_ChIP-Seq_LNCaP_Human	0.80862348
89	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.80058253
90	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.78850545
91	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.77670406
92	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.76590100
93	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.76143664
94	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.75973267
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.75884041
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.75884041
97	ZNF263_19887448_ChIP-Seq_K562_Human	0.75442375
98	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.72466442
99	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.71867639
100	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.71323365

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	8.03043315
2	MP0002098_abnormal_vibrissa_morphology	6.85814314
3	MP0000647_abnormal_sebaceous_gland	6.15613284
4	MP0002796_impaired_skin_barrier	5.84517071
5	MP0005275_abnormal_skin_tensile	5.18014306
6	MP0000383_abnormal_hair_follicle	5.01441456
7	MP0010234_abnormal_vibrissa_follicle	4.83085679
8	MP0010678_abnormal_skin_adnexa	4.37686332
9	MP0000377_abnormal_hair_follicle	4.03209639
10	MP0005501_abnormal_skin_physiology	3.63740770
11	MP0000427_abnormal_hair_cycle	3.57693446
12	MP0003705_abnormal_hypodermis_morpholog	3.47046269
13	MP0002254_reproductive_system_inflammat	3.01694586
14	MP0001216_abnormal_epidermal_layer	2.70475119
15	MP0004381_abnormal_hair_follicle	2.68493856
16	MP0004947_skin_inflammation	2.34735201
17	MP0010771_integument_phenotype	2.32762210
18	MP0000367_abnormal_coat/_hair	2.32170508
19	MP0003453_abnormal_keratinocyte_physiol	2.24993967
20	MP0002060_abnormal_skin_morphology	2.12206930
21	MP0001243_abnormal_dermal_layer	2.09047843
22	MP0000467_abnormal_esophagus_morphology	1.94609886
23	MP0002234_abnormal_pharynx_morphology	1.82734654
24	MP0005409_darkened_coat_color	1.65908950
25	MP0000762_abnormal_tongue_morphology	1.55833784
26	MP0009931_abnormal_skin_appearance	1.49799421
27	MP0009053_abnormal_anal_canal	1.45631998
28	MP0003566_abnormal_cell_adhesion	1.42505941
29	MP0003941_abnormal_skin_development	1.27771552
30	MP0001191_abnormal_skin_condition	1.03031841
31	MP0001661_extended_life_span	0.98907160
32	MP0004885_abnormal_endolymph	0.97596925
33	MP0002095_abnormal_skin_pigmentation	0.93517457
34	MP0004264_abnormal_extraembryonic_tissu	0.93157549
35	MP0004185_abnormal_adipocyte_glucose	0.93001506
36	MP0001851_eye_inflammation	0.76109689
37	MP0008438_abnormal_cutaneous_collagen	0.72284183
38	MP0001346_abnormal_lacrimal_gland	0.67731226
39	MP0000566_synostosis	0.66481567
40	MP0001340_abnormal_eyelid_morphology	0.65853233
41	MP0003315_abnormal_perineum_morphology	0.64509559
42	MP0002877_abnormal_melanocyte_morpholog	0.63345963
43	MP0001849_ear_inflammation	0.61305181
44	MP0002282_abnormal_trachea_morphology	0.56064037
45	MP0000627_abnormal_mammary_gland	0.54664986
46	MP0010030_abnormal_orbit_morphology	0.54203210
47	MP0003191_abnormal_cellular_cholesterol	0.52216710
48	MP0005023_abnormal_wound_healing	0.51135719
49	MP0003755_abnormal_palate_morphology	0.50768660
50	MP0005451_abnormal_body_composition	0.48470030
51	MP0001784_abnormal_fluid_regulation	0.45731096
52	MP0002970_abnormal_white_adipose	0.44979309
53	MP0002111_abnormal_tail_morphology	0.37818267
54	MP0010352_gastrointestinal_tract_polyps	0.36747519
55	MP0005075_abnormal_melanosome_morpholog	0.35783305
56	MP0004272_abnormal_basement_membrane	0.32851235
57	MP0003385_abnormal_body_wall	0.29263960
58	MP0002697_abnormal_eye_size	0.29124669
59	MP0000537_abnormal_urethra_morphology	0.29007467
60	MP0002177_abnormal_outer_ear	0.28611326
61	MP0002249_abnormal_larynx_morphology	0.27741338
62	MP0003950_abnormal_plasma_membrane	0.26054841
63	MP0000465_gastrointestinal_hemorrhage	0.24720586
64	MP0005248_abnormal_Harderian_gland	0.24653695
65	MP0002166_altered_tumor_susceptibility	0.24234724
66	MP0002009_preneoplasia	0.24007450
67	MP0002006_tumorigenesis	0.23927516
68	MP0003763_abnormal_thymus_physiology	0.22679692
69	MP0009840_abnormal_foam_cell	0.21945702
70	MP0000678_abnormal_parathyroid_gland	0.21375191
71	MP0000432_abnormal_head_morphology	0.21291788
72	MP0003300_gastrointestinal_ulcer	0.20586218
73	MP0009384_cardiac_valve_regurgitation	0.18363963
74	MP0006054_spinal_hemorrhage	0.17643040
75	MP0003329_amyloid_beta_deposits	0.16475038
76	MP0005666_abnormal_adipose_tissue	0.16347913
77	MP0003935_abnormal_craniofacial_develop	0.15014940
78	MP0009379_abnormal_foot_pigmentation	0.14583972
79	MP0005193_abnormal_anterior_eye	0.13233734
80	MP0005367_renal/urinary_system_phenotyp	0.13054260
81	MP0000516_abnormal_urinary_system	0.13054260
82	MP0004019_abnormal_vitamin_homeostasis	0.12646628
83	MP0005375_adipose_tissue_phenotype	0.12027028
84	MP0003448_altered_tumor_morphology	0.11950597
85	MP0004742_abnormal_vestibular_system	0.11422840
86	MP0005076_abnormal_cell_differentiation	0.11154804
87	MP0001879_abnormal_lymphatic_vessel	0.10689135
88	MP0003638_abnormal_response/metabolism_	0.09707870
89	MP0000604_amyloidosis	0.08354133
90	MP0002233_abnormal_nose_morphology	0.08268490
91	MP0003011_delayed_dark_adaptation	0.07972898
92	MP0002090_abnormal_vision	0.06409170
93	MP0000462_abnormal_digestive_system	0.05698897
94	MP0000428_abnormal_craniofacial_morphol	0.05310794
95	MP0003075_altered_response_to	0.05221171
96	MP0001958_emphysema	0.05128624
97	MP0001730_embryonic_growth_arrest	0.05095121
98	MP0000538_abnormal_urinary_bladder	0.04730498
99	MP0005508_abnormal_skeleton_morphology	0.04632300
100	MP0008569_lethality_at_weaning	0.04496874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	9.38130808
2	Abnormality of nail color (HP:0100643)	7.22148302
3	Nail dystrophy (HP:0008404)	7.19688204
4	Abnormal hair laboratory examination (HP:0003328)	5.93530568
5	Fragile nails (HP:0001808)	5.71579775
6	Alopecia of scalp (HP:0002293)	5.42416051
7	Follicular hyperkeratosis (HP:0007502)	5.35481283
8	Fine hair (HP:0002213)	5.19247578
9	Thick nail (HP:0001805)	5.13651797
10	Palmoplantar hyperkeratosis (HP:0000972)	5.10825034
11	Palmar hyperkeratosis (HP:0010765)	4.81811776
12	Onycholysis (HP:0001806)	4.65229025
13	Plantar hyperkeratosis (HP:0007556)	4.63519231
14	Increased IgE level (HP:0003212)	4.26441215
15	Right ventricular cardiomyopathy (HP:0011663)	4.10055349
16	Oral leukoplakia (HP:0002745)	3.94539135
17	Sparse eyelashes (HP:0000653)	3.77912364
18	Erythema (HP:0010783)	3.62382063
19	Milia (HP:0001056)	3.39906364
20	Parakeratosis (HP:0001036)	3.19003971
21	Congenital, generalized hypertrichosis (HP:0004540)	3.14229139
22	Abnormality of the frontal sinuses (HP:0002687)	3.06491095
23	Amelogenesis imperfecta (HP:0000705)	3.03151407
24	Erythroderma (HP:0001019)	2.90295099
25	Ridged nail (HP:0001807)	2.87057378
26	Curly hair (HP:0002212)	2.65914428
27	Intention tremor (HP:0002080)	2.63731085
28	Abnormal blistering of the skin (HP:0008066)	2.55507145
29	Congenital ichthyosiform erythroderma (HP:0007431)	2.44514125
30	Aplasia cutis congenita (HP:0001057)	2.43201838
31	Dry hair (HP:0011359)	2.43159407
32	Natal tooth (HP:0000695)	2.36656199
33	Neck muscle weakness (HP:0000467)	2.32751464
34	Torticollis (HP:0000473)	2.27025984
35	Advanced eruption of teeth (HP:0006288)	2.25601085
36	Hypohidrosis (HP:0000966)	2.17843865
37	Palmoplantar keratoderma (HP:0000982)	2.10832657
38	Corneal erosion (HP:0200020)	2.08778027
39	Hypotrichosis (HP:0001006)	14.2058595
40	Woolly hair (HP:0002224)	11.1990056
41	Slow-growing hair (HP:0002217)	10.9061760
42	Abnormality of hair growth rate (HP:0011363)	10.9061760
43	Brittle hair (HP:0002299)	10.0812237
44	Pruritus (HP:0000989)	1.96659660
45	Ventricular tachycardia (HP:0004756)	1.93288515
46	Craniofacial dystonia (HP:0012179)	1.91006695
47	Absent eyelashes (HP:0000561)	1.80553865
48	Concave nail (HP:0001598)	1.80511754
49	Difficulty walking (HP:0002355)	1.79709638
50	Fatigable weakness (HP:0003473)	1.77895880
51	Abnormality of the neuromuscular junction (HP:0003398)	1.77895880
52	Abnormality of the pupil (HP:0000615)	1.77421530
53	Abnormality of the parietal bone (HP:0002696)	1.76295307
54	Ventricular fibrillation (HP:0001663)	1.75656927
55	Focal dystonia (HP:0004373)	1.74336504
56	Abnormality of the dental root (HP:0006486)	1.72858695
57	Taurodontia (HP:0000679)	1.72858695
58	Abnormality of permanent molar morphology (HP:0011071)	1.72858695
59	Abnormality of molar morphology (HP:0011070)	1.70012615
60	Abnormality of molar (HP:0011077)	1.70012615
61	Abnormality of dental color (HP:0011073)	1.69592814
62	Recurrent corneal erosions (HP:0000495)	1.69479397
63	Widely patent fontanelles and sutures (HP:0004492)	1.67191419
64	Blepharitis (HP:0000498)	1.61785573
65	Amniotic constriction ring (HP:0009775)	1.59509904
66	Abnormality of placental membranes (HP:0011409)	1.59509904
67	Conjunctival hamartoma (HP:0100780)	1.55823014
68	Carious teeth (HP:0000670)	1.53787497
69	Anonychia (HP:0001798)	1.51724707
70	Lip pit (HP:0100267)	1.51514499
71	Abnormality of the dental pulp (HP:0006479)	1.50775709
72	Hyporeflexia of lower limbs (HP:0002600)	1.47045178
73	Laryngomalacia (HP:0001601)	1.46833249
74	Keratoconjunctivitis sicca (HP:0001097)	1.44474823
75	Acanthosis nigricans (HP:0000956)	1.44230600
76	Autoamputation (HP:0001218)	1.39783254
77	Abnormality of the fingernails (HP:0001231)	1.37426873
78	Heterogeneous (HP:0001425)	1.36103700
79	Ectropion (HP:0000656)	1.35697709
80	Gangrene (HP:0100758)	1.35105385
81	Sudden death (HP:0001699)	1.34157637
82	Craniofacial hyperostosis (HP:0004493)	1.32823919
83	Unilateral renal agenesis (HP:0000122)	1.30009957
84	Abnormality of the aortic arch (HP:0012303)	1.29026928
85	Neonatal onset (HP:0003623)	1.28816631
86	Corneal dystrophy (HP:0001131)	1.28763592
87	Keratoconjunctivitis (HP:0001096)	1.27241182
88	Hyperhidrosis (HP:0000975)	1.24743083
89	Achilles tendon contracture (HP:0001771)	1.23983299
90	Sparse scalp hair (HP:0002209)	1.23449309
91	Hypergammaglobulinemia (HP:0010702)	1.23136088
92	Atrophic scars (HP:0001075)	1.20626566
93	Distal lower limb muscle weakness (HP:0009053)	1.17759096
94	Widely spaced teeth (HP:0000687)	1.17689582
95	Selective tooth agenesis (HP:0001592)	1.17266273
96	Abnormality of the Achilles tendon (HP:0005109)	1.16299706
97	Lack of skin elasticity (HP:0100679)	1.12436482
98	Variable expressivity (HP:0003828)	1.11780401
99	Skin ulcer (HP:0200042)	1.09162025
100	Abnormality of the gastric mucosa (HP:0004295)	1.09140123

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.30840449
2	FER	4.14918060
3	MAPKAPK3	3.99507713
4	ERN1	3.83720580
5	MAP3K6	3.72477045
6	EPHB2	3.17144242
7	TAOK1	2.92672743
8	LATS1	2.88881779
9	MAP3K3	2.78332653
10	MAP3K2	2.52899531
11	TRIB3	2.52175305
12	MAP3K11	2.00035729
13	RPS6KB2	1.92545845
14	FGFR2	1.82588861
15	MAP2K6	1.73813811
16	EEF2K	1.66326280
17	EPHB1	1.64598188
18	BCR	1.62520531
19	LATS2	1.60783559
20	PIK3CG	1.60144005
21	TTN	1.60063362
22	FGFR3	1.50894168
23	FGFR1	1.38492643
24	MST1R	1.36797390
25	FGFR4	1.34293914
26	CDK6	1.30684974
27	MAP3K1	1.26931348
28	NME1	1.26128897
29	PDGFRA	1.25133279
30	RIPK1	1.19114788
31	KSR2	1.15201712
32	PKN2	1.13789599
33	BMX	1.13008379
34	PTK6	1.11591892
35	BLK	1.10201681
36	MAP2K3	1.09018359
37	MAPKAPK2	1.06722741
38	PBK	1.03129841
39	MAP3K7	1.00469307
40	RPS6KA4	0.98409062
41	LRRK2	0.96824032
42	MAP3K9	0.91639152
43	MAP2K4	0.82993798
44	PTK2	0.80984773
45	MET	0.77772367
46	MAP2K1	0.75091042
47	SIK1	0.72148002
48	STK38	0.71383052
49	DYRK1B	0.70617830
50	ERBB4	0.69637963
51	STK38L	0.69205992
52	TESK1	0.68598802
53	TRPM7	0.66628945
54	PAK4	0.66282928
55	DDR2	0.64585768
56	PIM2	0.64324439
57	PRKD1	0.63505184
58	PAK3	0.63193502
59	TYK2	0.60759242
60	MAP3K5	0.60084471
61	MAP3K10	0.57253452
62	JAK1	0.55392463
63	TGFBR1	0.53822396
64	ERBB2	0.52814929
65	ERBB3	0.52810229
66	TYRO3	0.51979269
67	NTRK2	0.51475920
68	CDK19	0.51103502
69	MST4	0.49573414
70	PRKCI	0.49542261
71	NEK1	0.48993736
72	PRKCH	0.48097911
73	RET	0.48004469
74	PAK2	0.46534535
75	EPHA3	0.45533373
76	RPS6KA1	0.44092368
77	CSNK1E	0.42849508
78	GSK3A	0.41902424
79	ALK	0.37564408
80	PAK6	0.37227657
81	MAPK12	0.36428506
82	JAK2	0.36293757
83	STK3	0.32511130
84	TGFBR2	0.32201490
85	FYN	0.30131242
86	LIMK1	0.29959785
87	MAP3K8	0.29794263
88	MAP2K2	0.29442620
89	CSNK1A1L	0.26553022
90	CSNK1G1	0.26148777
91	STK24	0.25402438
92	SRC	0.24979447
93	OBSCN	0.24613811
94	CSNK1A1	0.24461941
95	ILK	0.23656701
96	PDGFRB	0.23311499
97	CLK1	0.23058313
98	STK11	0.22928050
99	CSNK1D	0.22913175
100	PRKACG	0.22556088

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.82739074
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.79750064
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.03909444
4	Fatty acid elongation_Homo sapiens_hsa00062	2.91587029
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.55438361
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.31499671
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.84754293
8	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.81453762
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.80120045
10	Phenylalanine metabolism_Homo sapiens_hsa00360	1.79842317
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.70255698
12	Melanogenesis_Homo sapiens_hsa04916	1.62241703
13	Axon guidance_Homo sapiens_hsa04360	1.54990524
14	Caffeine metabolism_Homo sapiens_hsa00232	1.53287051
15	Thyroid cancer_Homo sapiens_hsa05216	1.47321725
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.44606728
17	Bladder cancer_Homo sapiens_hsa05219	1.43598403
18	Hippo signaling pathway_Homo sapiens_hsa04390	1.39184268
19	Glioma_Homo sapiens_hsa05214	1.38163137
20	Histidine metabolism_Homo sapiens_hsa00340	1.35082163
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.34746083
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.27509468
23	Mineral absorption_Homo sapiens_hsa04978	1.22719429
24	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.22360879
25	GnRH signaling pathway_Homo sapiens_hsa04912	1.20451115
26	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.17450657
27	Acute myeloid leukemia_Homo sapiens_hsa05221	1.17241598
28	Tight junction_Homo sapiens_hsa04530	1.13531181
29	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.08892422
30	Adherens junction_Homo sapiens_hsa04520	1.07342736
31	Long-term potentiation_Homo sapiens_hsa04720	1.06157337
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.05929207
33	Pancreatic secretion_Homo sapiens_hsa04972	1.05107791
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.03467075
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.02824660
36	ECM-receptor interaction_Homo sapiens_hsa04512	1.01629891
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99157161
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.97525525
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.96934518
40	Endometrial cancer_Homo sapiens_hsa05213	0.95817370
41	Non-small cell lung cancer_Homo sapiens_hsa05223	0.93115156
42	Pertussis_Homo sapiens_hsa05133	0.86714594
43	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.85864843
44	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.85267962
45	Long-term depression_Homo sapiens_hsa04730	0.84501173
46	Ras signaling pathway_Homo sapiens_hsa04014	0.83910266
47	Wnt signaling pathway_Homo sapiens_hsa04310	0.82896289
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.78274439
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.77672528
50	Amoebiasis_Homo sapiens_hsa05146	0.75110637
51	MicroRNAs in cancer_Homo sapiens_hsa05206	0.72516382
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72305121
53	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67886552
54	Hepatitis C_Homo sapiens_hsa05160	0.67659238
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.66939842
56	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.66748582
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.64380071
58	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.62484105
59	Insulin resistance_Homo sapiens_hsa04931	0.61371088
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61178547
61	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.60567457
62	Renin secretion_Homo sapiens_hsa04924	0.60002735
63	Gastric acid secretion_Homo sapiens_hsa04971	0.59164580
64	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.59107197
65	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.57212058
66	Rap1 signaling pathway_Homo sapiens_hsa04015	0.57102173
67	Focal adhesion_Homo sapiens_hsa04510	0.55453374
68	Phototransduction_Homo sapiens_hsa04744	0.53674854
69	p53 signaling pathway_Homo sapiens_hsa04115	0.53398284
70	Gap junction_Homo sapiens_hsa04540	0.53134083
71	Fatty acid metabolism_Homo sapiens_hsa01212	0.52549845
72	Renal cell carcinoma_Homo sapiens_hsa05211	0.51268576
73	Salmonella infection_Homo sapiens_hsa05132	0.50832125
74	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.50744795
75	Platelet activation_Homo sapiens_hsa04611	0.50523174
76	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50503318
77	Protein digestion and absorption_Homo sapiens_hsa04974	0.49858209
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48938351
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.48527635
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48310935
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44420932
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42890065
83	Toxoplasmosis_Homo sapiens_hsa05145	0.42475217
84	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.41937800
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41203119
86	Butanoate metabolism_Homo sapiens_hsa00650	0.40737037
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.40730967
88	Melanoma_Homo sapiens_hsa05218	0.39299409
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38797368
90	Tuberculosis_Homo sapiens_hsa05152	0.38570331
91	Salivary secretion_Homo sapiens_hsa04970	0.38525512
92	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36014321
93	Prolactin signaling pathway_Homo sapiens_hsa04917	0.35644440
94	Fatty acid degradation_Homo sapiens_hsa00071	0.35087171
95	Notch signaling pathway_Homo sapiens_hsa04330	0.34278724
96	Pathways in cancer_Homo sapiens_hsa05200	0.34054753
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.32671444
98	Prion diseases_Homo sapiens_hsa05020	0.32600621
99	Insulin signaling pathway_Homo sapiens_hsa04910	0.32140588
100	Endocytosis_Homo sapiens_hsa04144	0.32037505

KRTAP6-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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