KRTAP6-2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1virion attachment to host cell (GO:0019062)9.65970966
2adhesion of symbiont to host cell (GO:0044650)9.65970966
3peptide cross-linking (GO:0018149)8.84579994
4establishment of skin barrier (GO:0061436)8.10298093
5adhesion of symbiont to host (GO:0044406)8.09740307
6citrulline biosynthetic process (GO:0019240)8.04498507
7hair follicle morphogenesis (GO:0031069)7.74752041
8regulation of water loss via skin (GO:0033561)7.04573750
9intermediate filament cytoskeleton organization (GO:0045104)6.93269490
10intermediate filament-based process (GO:0045103)6.78764315
11epidermis development (GO:0008544)6.60620161
12keratinocyte differentiation (GO:0030216)6.53155386
13cell wall macromolecule metabolic process (GO:0044036)6.31998930
14cell wall macromolecule catabolic process (GO:0016998)6.31998930
15hemidesmosome assembly (GO:0031581)5.84268921
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.45142646
17citrulline metabolic process (GO:0000052)5.28717552
18molting cycle process (GO:0022404)5.25045252
19hair cycle process (GO:0022405)5.25045252
20skin morphogenesis (GO:0043589)5.09080822
21epidermal cell differentiation (GO:0009913)5.03358726
22peptidyl-arginine modification (GO:0018195)4.75072189
23multicellular organismal water homeostasis (GO:0050891)4.67637284
24keratinocyte development (GO:0003334)4.61355015
25negative regulation of keratinocyte proliferation (GO:0010839)4.09073706
26hair cycle (GO:0042633)32.8804312
27molting cycle (GO:0042303)32.8804312
28water homeostasis (GO:0030104)3.81842413
29tooth mineralization (GO:0034505)3.64578080
30ectoderm development (GO:0007398)3.60013376
31hair follicle development (GO:0001942)3.41956488
32phosphatidylinositol acyl-chain remodeling (GO:0036149)3.27645867
33negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.24377432
34epithelium development (GO:0060429)3.21756319
35positive regulation of hair cycle (GO:0042635)3.15473215
36positive regulation of hair follicle development (GO:0051798)3.15473215
37regulation of keratinocyte differentiation (GO:0045616)3.15324535
38fatty acid elongation (GO:0030497)3.15264375
39phosphatidylserine acyl-chain remodeling (GO:0036150)2.95861874
40regulation of hair follicle development (GO:0051797)2.95206191
41bone trabecula formation (GO:0060346)2.89969546
42positive regulation of epidermis development (GO:0045684)2.88182520
43gap junction assembly (GO:0016264)2.79610244
44regulation of hair cycle (GO:0042634)2.71957246
45atrioventricular valve morphogenesis (GO:0003181)2.70507940
46positive regulation of meiotic cell cycle (GO:0051446)2.65892229
47negative regulation of protein localization to plasma membrane (GO:1903077)2.62743366
48phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.62086840
49regulation of epidermal cell differentiation (GO:0045604)2.59299406
50regulation of epidermis development (GO:0045682)2.57598870
51positive regulation of epidermal cell differentiation (GO:0045606)2.56512669
52skin development (GO:0043588)2.39199811
53ventricular cardiac muscle cell action potential (GO:0086005)2.37360655
54regulation of keratinocyte proliferation (GO:0010837)2.37311192
55keratinocyte proliferation (GO:0043616)2.34768273
56negative regulation of cell fate specification (GO:0009996)2.33679377
57epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.33542105
58phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.26351249
59positive regulation of monocyte chemotaxis (GO:0090026)2.22832029
60cell surface receptor signaling pathway involved in heart development (GO:0061311)2.21738995
61phosphatidylserine metabolic process (GO:0006658)2.21364610
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.16979271
63wound healing, spreading of epidermal cells (GO:0035313)2.16621860
64regulation of mesenchymal cell apoptotic process (GO:2001053)2.10940059
65regulation of cardioblast differentiation (GO:0051890)2.09863566
66lymph vessel development (GO:0001945)2.07956329
67cranial suture morphogenesis (GO:0060363)2.07790066
68epithelial cell-cell adhesion (GO:0090136)2.07331489
69cell-substrate junction assembly (GO:0007044)2.00372404
70keratinization (GO:0031424)13.8283237
71intermediate filament organization (GO:0045109)12.2367627
72desmosome organization (GO:0002934)10.8231796
73regulation of somitogenesis (GO:0014807)1.99965682
74phosphatidylcholine acyl-chain remodeling (GO:0036151)1.98677067
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.98468647
76regulation of heart rate by cardiac conduction (GO:0086091)1.97768766
77regulation of ruffle assembly (GO:1900027)1.95808647
78regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.92342161
79very long-chain fatty acid metabolic process (GO:0000038)1.91181472
80myotube differentiation (GO:0014902)1.91172894
81non-canonical Wnt signaling pathway (GO:0035567)1.91116459
82cell communication involved in cardiac conduction (GO:0086065)1.90785917
83cytoskeletal anchoring at plasma membrane (GO:0007016)1.88440105
84aging (GO:0007568)1.87286514
85outflow tract septum morphogenesis (GO:0003148)1.84037961
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.83689906
87negative regulation of epidermis development (GO:0045683)1.82346568
88amyloid precursor protein catabolic process (GO:0042987)1.81232235
89ephrin receptor signaling pathway (GO:0048013)1.76313563
90long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.72699537
91cellular component disassembly involved in execution phase of apoptosis (GO:0006921)1.72185167
92long-chain fatty acid biosynthetic process (GO:0042759)1.71601449
93establishment of tissue polarity (GO:0007164)1.71520644
94establishment of planar polarity (GO:0001736)1.71520644
95antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.66189230
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.66189230
97long-chain fatty-acyl-CoA metabolic process (GO:0035336)1.65947353
98amyloid precursor protein metabolic process (GO:0042982)1.62653295
99eyelid development in camera-type eye (GO:0061029)1.62306252
100regulation of monocyte chemotaxis (GO:0090025)1.62028928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.37844490
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.75881978
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.52016989
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.21709906
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42365897
6CTCF_20526341_ChIP-Seq_ESCs_Human2.13652028
7TP63_17297297_ChIP-ChIP_HaCaT_Human13.1609401
8EGR1_19032775_ChIP-ChIP_M12_Human1.96186616
9BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.94902967
10NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.86777902
11SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85058014
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79854738
13E2F1_20622854_ChIP-Seq_HELA_Human1.75933608
14TAF2_19829295_ChIP-Seq_ESCs_Human1.74404992
15P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.71516756
16NANOG_20526341_ChIP-Seq_ESCs_Human1.66766718
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62385363
18ERG_20517297_ChIP-Seq_VCAP_Human1.61263967
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59638050
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59638050
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.55646284
22CSB_26484114_Chip-Seq_FIBROBLAST_Human1.55440738
23CTCF_27219007_Chip-Seq_Bcells_Human1.52779686
24TP53_20018659_ChIP-ChIP_R1E_Mouse1.51087367
25P53_21459846_ChIP-Seq_SAOS-2_Human1.48255268
26MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.42544399
27TP63_22573176_ChIP-Seq_HFKS_Human1.42377762
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41675912
29BCL6_27268052_Chip-Seq_Bcells_Human1.39524847
30YY1_22570637_ChIP-Seq_MALME-3M_Human1.38002197
31RACK7_27058665_Chip-Seq_MCF-7_Human1.37149934
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.35864288
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35016590
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33178215
35BCOR_27268052_Chip-Seq_Bcells_Human1.28137146
36AHR_22903824_ChIP-Seq_MCF-7_Human1.27304083
37ATF3_27146783_Chip-Seq_COLON_Human1.27079612
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27036738
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.25566552
40LXR_22292898_ChIP-Seq_THP-1_Human1.24471049
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.23761936
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21491303
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.21132584
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20905833
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19769055
46TP63_23658742_ChIP-Seq_EP156T_Human1.17229412
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15386013
48GATA6_21074721_ChIP-Seq_CACO-2_Human1.14603823
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13048607
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.11961969
51CEBPB_22108803_ChIP-Seq_LS180_Human1.11738348
52P68_20966046_ChIP-Seq_HELA_Human1.10089913
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.09781281
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07664042
55TP53_18474530_ChIP-ChIP_U2OS_Human1.06786754
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05879138
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05582846
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04600153
59RAC3_21632823_ChIP-Seq_H3396_Human1.03769911
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03577995
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.02969094
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02679382
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02495219
64PHF8_20622854_ChIP-Seq_HELA_Human1.01675517
65KLF5_25053715_ChIP-Seq_YYC3_Human1.01553798
66E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00484243
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99731350
68GATA4_25053715_ChIP-Seq_YYC3_Human0.98990978
69SOX2_21211035_ChIP-Seq_LN229_Human0.96135529
70SMC4_20622854_ChIP-Seq_HELA_Human0.94138424
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93896937
72ELF1_20517297_ChIP-Seq_JURKAT_Human0.93473483
73RING1B_27294783_Chip-Seq_ESCs_Mouse0.91918387
74SA1_27219007_Chip-Seq_ERYTHROID_Human0.89501060
75AR_21572438_ChIP-Seq_LNCaP_Human0.88884024
76RXR_22108803_ChIP-Seq_LS180_Human0.88779902
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.88689232
78SOX2_20726797_ChIP-Seq_SW620_Human0.87617802
79EZH2_27294783_Chip-Seq_ESCs_Mouse0.87496792
80FOXH1_21741376_ChIP-Seq_ESCs_Human0.87080906
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85976703
82RNF2_27304074_Chip-Seq_ESCs_Mouse0.85215228
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84780612
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81143432
85SPI1_20517297_ChIP-Seq_HL60_Human0.81089681
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.80994984
87ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80950495
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80477534
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.79149853
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78250250
91IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78194143
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77398115
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76550629
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75868422
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.75638251
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75638251
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75576245
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.75061429
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74541214
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74484801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.00447753
2MP0002098_abnormal_vibrissa_morphology6.29833643
3MP0002796_impaired_skin_barrier6.23234358
4MP0000647_abnormal_sebaceous_gland5.92006765
5MP0005275_abnormal_skin_tensile5.47223652
6MP0000383_abnormal_hair_follicle4.79664752
7MP0010234_abnormal_vibrissa_follicle4.45426866
8MP0010678_abnormal_skin_adnexa4.13363425
9MP0000377_abnormal_hair_follicle3.90892603
10MP0005501_abnormal_skin_physiology3.84433353
11MP0000427_abnormal_hair_cycle3.41390243
12MP0003705_abnormal_hypodermis_morpholog3.33817764
13MP0001216_abnormal_epidermal_layer2.88089638
14MP0002254_reproductive_system_inflammat2.87608778
15MP0004381_abnormal_hair_follicle2.71791436
16MP0004947_skin_inflammation2.60746731
17MP0010771_integument_phenotype2.45657665
18MP0003453_abnormal_keratinocyte_physiol2.40854533
19MP0002060_abnormal_skin_morphology2.33567475
20MP0000467_abnormal_esophagus_morphology2.24548945
21MP0000367_abnormal_coat/_hair2.19543547
22MP0001243_abnormal_dermal_layer2.10839574
23MP0000566_synostosis1.92643002
24MP0003941_abnormal_skin_development1.80654281
25MP0002234_abnormal_pharynx_morphology1.72882888
26MP0005409_darkened_coat_color1.71787539
27MP0000762_abnormal_tongue_morphology1.71598259
28MP0009931_abnormal_skin_appearance1.58405190
29MP0003566_abnormal_cell_adhesion1.34359593
30MP0009053_abnormal_anal_canal1.34148847
31MP0001191_abnormal_skin_condition1.12666169
32MP0002095_abnormal_skin_pigmentation1.02585050
33MP0001661_extended_life_span0.86546064
34MP0004185_abnormal_adipocyte_glucose0.86079771
35MP0004885_abnormal_endolymph0.82949782
36MP0008438_abnormal_cutaneous_collagen0.81615890
37MP0001851_eye_inflammation0.80595006
38MP0004264_abnormal_extraembryonic_tissu0.77560398
39MP0001346_abnormal_lacrimal_gland0.75642379
40MP0001188_hyperpigmentation0.73875322
41MP0001340_abnormal_eyelid_morphology0.72390733
42MP0001849_ear_inflammation0.61412941
43MP0003315_abnormal_perineum_morphology0.61204922
44MP0005451_abnormal_body_composition0.59266690
45MP0002282_abnormal_trachea_morphology0.56851399
46MP0003755_abnormal_palate_morphology0.52098758
47MP0001784_abnormal_fluid_regulation0.51868019
48MP0002877_abnormal_melanocyte_morpholog0.51288755
49MP0003191_abnormal_cellular_cholesterol0.50661009
50MP0009379_abnormal_foot_pigmentation0.49986668
51MP0010030_abnormal_orbit_morphology0.47477814
52MP0000627_abnormal_mammary_gland0.46911515
53MP0005248_abnormal_Harderian_gland0.43335615
54MP0005023_abnormal_wound_healing0.42714706
55MP0002970_abnormal_white_adipose0.41190337
56MP0002177_abnormal_outer_ear0.41004486
57MP0009780_abnormal_chondrocyte_physiolo0.40388148
58MP0001958_emphysema0.39883564
59MP0002111_abnormal_tail_morphology0.38739658
60MP0002697_abnormal_eye_size0.37361050
61MP0000465_gastrointestinal_hemorrhage0.32479016
62MP0002249_abnormal_larynx_morphology0.30721461
63MP0003385_abnormal_body_wall0.29541423
64MP0004272_abnormal_basement_membrane0.25501832
65MP0003763_abnormal_thymus_physiology0.25321301
66MP0000678_abnormal_parathyroid_gland0.25126396
67MP0000432_abnormal_head_morphology0.23824845
68MP0005075_abnormal_melanosome_morpholog0.23795742
69MP0003950_abnormal_plasma_membrane0.23706621
70MP0002006_tumorigenesis0.21796195
71MP0010352_gastrointestinal_tract_polyps0.18654108
72MP0002166_altered_tumor_susceptibility0.17948134
73MP0006054_spinal_hemorrhage0.17896307
74MP0004742_abnormal_vestibular_system0.15633776
75MP0005666_abnormal_adipose_tissue0.14731578
76MP0009840_abnormal_foam_cell0.14216502
77MP0003935_abnormal_craniofacial_develop0.13307605
78MP0003448_altered_tumor_morphology0.13015326
79MP0000428_abnormal_craniofacial_morphol0.12343673
80MP0002009_preneoplasia0.11515056
81MP0000537_abnormal_urethra_morphology0.11455629
82MP0009384_cardiac_valve_regurgitation0.11113717
83MP0005193_abnormal_anterior_eye0.10976357
84MP0000733_abnormal_muscle_development0.10951286
85MP0002089_abnormal_postnatal_growth/wei0.10669246
86MP0001299_abnormal_eye_distance/0.09965300
87MP0005508_abnormal_skeleton_morphology0.09713372
88MP0003300_gastrointestinal_ulcer0.09433069
89MP0003011_delayed_dark_adaptation0.09095407
90MP0008569_lethality_at_weaning0.08217691
91MP0003329_amyloid_beta_deposits0.07779254
92MP0003045_fibrosis0.07723854
93MP0005367_renal/urinary_system_phenotyp0.07378365
94MP0000516_abnormal_urinary_system0.07378365
95MP0000750_abnormal_muscle_regeneration0.07101901
96MP0005375_adipose_tissue_phenotype0.06394824
97MP0002233_abnormal_nose_morphology0.06030791
98MP0004019_abnormal_vitamin_homeostasis0.05399897
99MP0005257_abnormal_intraocular_pressure0.04915995
100MP0001730_embryonic_growth_arrest0.04908947

Predicted human phenotypes

RankGene SetZ-score
1Brittle hair (HP:0002299)9.34636356
2Pili torti (HP:0003777)9.03074941
3Abnormality of nail color (HP:0100643)7.58021179
4Nail dystrophy (HP:0008404)7.08369525
5Abnormal hair laboratory examination (HP:0003328)5.79991265
6Fragile nails (HP:0001808)5.55348731
7Palmoplantar hyperkeratosis (HP:0000972)5.51851950
8Alopecia of scalp (HP:0002293)5.49228511
9Follicular hyperkeratosis (HP:0007502)5.43775553
10Thick nail (HP:0001805)5.41768861
11Palmar hyperkeratosis (HP:0010765)5.20694382
12Increased IgE level (HP:0003212)5.18660382
13Oral leukoplakia (HP:0002745)5.07653202
14Plantar hyperkeratosis (HP:0007556)5.00585058
15Onycholysis (HP:0001806)4.88291526
16Fine hair (HP:0002213)4.79768686
17Right ventricular cardiomyopathy (HP:0011663)4.07166253
18Erythema (HP:0010783)4.04202740
19Sparse eyelashes (HP:0000653)3.89909252
20Milia (HP:0001056)3.51758237
21Ridged nail (HP:0001807)3.51139125
22Erythroderma (HP:0001019)3.35901504
23Abnormal blistering of the skin (HP:0008066)2.97583027
24Congenital, generalized hypertrichosis (HP:0004540)2.90631086
25Parakeratosis (HP:0001036)2.87949513
26Amelogenesis imperfecta (HP:0000705)2.79345975
27Abnormality of the frontal sinuses (HP:0002687)2.77002090
28Congenital ichthyosiform erythroderma (HP:0007431)2.74683376
29Curly hair (HP:0002212)2.68799514
30Corneal erosion (HP:0200020)2.40677980
31Intention tremor (HP:0002080)2.39829802
32Palmoplantar keratoderma (HP:0000982)2.36156509
33Conjunctival hamartoma (HP:0100780)2.34597367
34Aplasia cutis congenita (HP:0001057)2.32568678
35Natal tooth (HP:0000695)2.29713338
36Dry hair (HP:0011359)2.25171638
37Advanced eruption of teeth (HP:0006288)2.23845366
38Hypohidrosis (HP:0000966)2.23766484
39Neck muscle weakness (HP:0000467)2.19618599
40Selective tooth agenesis (HP:0001592)2.11750053
41Recurrent corneal erosions (HP:0000495)2.11049528
42Torticollis (HP:0000473)2.00969963
43Pruritus (HP:0000989)2.00883709
44Hypotrichosis (HP:0001006)13.6270994
45Woolly hair (HP:0002224)10.5255893
46Slow-growing hair (HP:0002217)10.0425082
47Abnormality of hair growth rate (HP:0011363)10.0425082
48Blepharitis (HP:0000498)1.94046391
49Ventricular tachycardia (HP:0004756)1.90143155
50Abnormality of the dental root (HP:0006486)1.77437376
51Taurodontia (HP:0000679)1.77437376
52Abnormality of permanent molar morphology (HP:0011071)1.77437376
53Fatigable weakness (HP:0003473)1.77030609
54Abnormality of the neuromuscular junction (HP:0003398)1.77030609
55Abnormality of molar (HP:0011077)1.76861406
56Abnormality of molar morphology (HP:0011070)1.76861406
57Squamous cell carcinoma (HP:0002860)1.75503558
58Absent eyelashes (HP:0000561)1.75104552
59Concave nail (HP:0001598)1.70080785
60Gangrene (HP:0100758)1.68678405
61Carious teeth (HP:0000670)1.68299371
62Laryngomalacia (HP:0001601)1.66375994
63Anonychia (HP:0001798)1.65783553
64Ventricular fibrillation (HP:0001663)1.65589040
65Craniofacial dystonia (HP:0012179)1.64977184
66Atrophic scars (HP:0001075)1.61990654
67Hyperhidrosis (HP:0000975)1.61175831
68Difficulty walking (HP:0002355)1.59754091
69Acanthosis nigricans (HP:0000956)1.58728015
70Abnormality of the pupil (HP:0000615)1.57879178
71Abnormality of the dental pulp (HP:0006479)1.53969100
72Abnormality of the parietal bone (HP:0002696)1.53580111
73Hamartoma of the eye (HP:0010568)1.52835311
74Focal dystonia (HP:0004373)1.51108449
75Lip pit (HP:0100267)1.48527553
76Abnormality of the fingernails (HP:0001231)1.47673525
77Widely patent fontanelles and sutures (HP:0004492)1.46914626
78Hypergammaglobulinemia (HP:0010702)1.46538119
79Ectropion (HP:0000656)1.46212163
80Hyporeflexia of lower limbs (HP:0002600)1.46167187
81Abnormality of dental color (HP:0011073)1.45995448
82Corneal dystrophy (HP:0001131)1.43696963
83Keratoconjunctivitis sicca (HP:0001097)1.38386917
84Amniotic constriction ring (HP:0009775)1.38351199
85Abnormality of placental membranes (HP:0011409)1.38351199
86Neonatal death (HP:0003811)1.38190184
87Sparse scalp hair (HP:0002209)1.37898068
88Aplasia involving bones of the extremities (HP:0009825)1.31167211
89Aplasia involving bones of the upper limbs (HP:0009823)1.31167211
90Aplasia of the phalanges of the hand (HP:0009802)1.31167211
91Neonatal onset (HP:0003623)1.27055762
92Heterogeneous (HP:0001425)1.26274905
93Sudden death (HP:0001699)1.26170386
94Lack of skin elasticity (HP:0100679)1.25579405
95Unilateral renal agenesis (HP:0000122)1.24903042
96Distal lower limb muscle weakness (HP:0009053)1.24284799
97Skin ulcer (HP:0200042)1.22992820
98Keratoconjunctivitis (HP:0001096)1.22570129
99Autoamputation (HP:0001218)1.20312476
100Craniofacial hyperostosis (HP:0004493)1.18929796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.53827605
2MAP3K64.13854224
3TAOK13.89527198
4FER3.80100148
5EPHA23.41496315
6MAPKAPK33.28347898
7ERN13.22019136
8EPHB22.73762120
9FGFR32.62828804
10LATS22.43475156
11FGFR12.39213763
12MAP3K32.34831671
13MAP3K22.10905003
14EPHB12.09645620
15RIPK12.06552857
16TRIB31.96339066
17TTK1.91999583
18MAP3K111.88204756
19BCR1.67724806
20RPS6KB21.52885131
21STK38L1.46693332
22SIK11.42424043
23MAP2K61.41960591
24FGFR21.41065730
25MST1R1.40023386
26PIK3CG1.38796536
27TTN1.38393836
28BLK1.32305378
29MAP2K41.24703993
30BMX1.22472814
31PBK1.21061009
32EEF2K1.20680285
33FGFR41.20121157
34MAP3K11.07538109
35PDGFRA1.03911451
36CDK60.98527001
37PTK60.96235534
38MAPKAPK20.92599094
39STK380.90329227
40KSR20.90148025
41MAP3K70.89740376
42MAP3K50.83503570
43DYRK1B0.80190646
44LRRK20.79786208
45PTK20.78205323
46PAK40.77662366
47PKN20.76482863
48MAP3K100.75806599
49MAP2K30.74647048
50MAP3K90.73345795
51NME10.71353903
52RPS6KA40.70948204
53MET0.68938355
54TGFBR10.68583412
55NTRK20.67275029
56STK30.66727472
57EPHA30.65636027
58MAP2K10.57665006
59ALK0.57560487
60PAK60.54506614
61MAPK120.54317950
62ERBB40.52660630
63CSNK1A1L0.52341806
64RET0.50576873
65ERBB20.45356750
66JAK10.43478147
67PAK30.42536651
68DDR20.42314475
69PRKD10.41478554
70PAK20.40515874
71TYK20.40389035
72CSNK1E0.39748660
73TRPM70.38723805
74BMPR1B0.37882439
75MARK20.35537310
76JAK30.33787946
77STK110.33509284
78NEK20.33301835
79PRKCI0.32294456
80MAP2K20.31861969
81PIM20.31686960
82DMPK0.31523294
83OBSCN0.30824793
84TESK10.29808477
85FYN0.29530129
86RPS6KA10.28991833
87CLK10.28595557
88TGFBR20.27404878
89MAPK80.27344299
90ATR0.25309400
91LIMK10.24867943
92IKBKE0.23976016
93STK240.23610565
94PRKCH0.23486978
95SRC0.23150015
96JAK20.21982670
97CDK190.21288661
98GSK3A0.21233275
99MST40.21053471
100TYRO30.20497655

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.58773529
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.57903831
3Fatty acid elongation_Homo sapiens_hsa000623.59549029
4Fat digestion and absorption_Homo sapiens_hsa049752.75256223
5Ether lipid metabolism_Homo sapiens_hsa005652.47023577
6Nitrogen metabolism_Homo sapiens_hsa009102.24529916
7Basal cell carcinoma_Homo sapiens_hsa052172.18953000
8Phenylalanine metabolism_Homo sapiens_hsa003602.01788916
9Arachidonic acid metabolism_Homo sapiens_hsa005901.92109907
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71053432
11Bladder cancer_Homo sapiens_hsa052191.67761206
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63915480
13VEGF signaling pathway_Homo sapiens_hsa043701.63157052
14Melanogenesis_Homo sapiens_hsa049161.57478571
15Axon guidance_Homo sapiens_hsa043601.51072557
16Dorso-ventral axis formation_Homo sapiens_hsa043201.50373161
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.41338653
18Hippo signaling pathway_Homo sapiens_hsa043901.36654096
19Histidine metabolism_Homo sapiens_hsa003401.33865985
20Glioma_Homo sapiens_hsa052141.30129575
21GnRH signaling pathway_Homo sapiens_hsa049121.28303112
22Proteoglycans in cancer_Homo sapiens_hsa052051.26537947
23Steroid biosynthesis_Homo sapiens_hsa001001.25301735
24Thyroid cancer_Homo sapiens_hsa052161.24093748
25Hedgehog signaling pathway_Homo sapiens_hsa043401.22535913
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19192936
27Caffeine metabolism_Homo sapiens_hsa002321.16218668
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14060883
29beta-Alanine metabolism_Homo sapiens_hsa004101.14019746
30Acute myeloid leukemia_Homo sapiens_hsa052211.11652899
31ECM-receptor interaction_Homo sapiens_hsa045121.09633950
32Staphylococcus aureus infection_Homo sapiens_hsa051501.09143217
33Adherens junction_Homo sapiens_hsa045201.05213218
34Long-term potentiation_Homo sapiens_hsa047201.03890877
35Pertussis_Homo sapiens_hsa051331.03314162
36Long-term depression_Homo sapiens_hsa047301.03272336
37Pancreatic secretion_Homo sapiens_hsa049721.02085956
38PPAR signaling pathway_Homo sapiens_hsa033201.01062761
39Mineral absorption_Homo sapiens_hsa049780.99480525
40Tight junction_Homo sapiens_hsa045300.97348264
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93659871
42Tyrosine metabolism_Homo sapiens_hsa003500.89928074
43Ras signaling pathway_Homo sapiens_hsa040140.88736472
44p53 signaling pathway_Homo sapiens_hsa041150.88006813
45Endometrial cancer_Homo sapiens_hsa052130.87014915
46Wnt signaling pathway_Homo sapiens_hsa043100.86251374
47Non-small cell lung cancer_Homo sapiens_hsa052230.85953733
48MicroRNAs in cancer_Homo sapiens_hsa052060.83664589
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.80237976
50Amoebiasis_Homo sapiens_hsa051460.79806041
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78471252
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.76373873
53Estrogen signaling pathway_Homo sapiens_hsa049150.75934713
54Fatty acid metabolism_Homo sapiens_hsa012120.75313223
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74397770
56Phototransduction_Homo sapiens_hsa047440.72601866
57Butanoate metabolism_Homo sapiens_hsa006500.71938085
58Renin secretion_Homo sapiens_hsa049240.71551227
59Salivary secretion_Homo sapiens_hsa049700.71257390
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.69935052
61TGF-beta signaling pathway_Homo sapiens_hsa043500.67179888
62Notch signaling pathway_Homo sapiens_hsa043300.67018130
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66379507
64Fatty acid degradation_Homo sapiens_hsa000710.65735975
65Rap1 signaling pathway_Homo sapiens_hsa040150.64900989
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.63792264
67Platelet activation_Homo sapiens_hsa046110.63715567
68Gastric acid secretion_Homo sapiens_hsa049710.62715211
69Hepatitis C_Homo sapiens_hsa051600.59310921
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59257644
71Protein digestion and absorption_Homo sapiens_hsa049740.57794198
72Gap junction_Homo sapiens_hsa045400.57061761
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55437979
74Focal adhesion_Homo sapiens_hsa045100.55255489
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54957084
76Salmonella infection_Homo sapiens_hsa051320.54198619
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.52957825
78Renal cell carcinoma_Homo sapiens_hsa052110.52658900
79Insulin resistance_Homo sapiens_hsa049310.50589695
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49950253
81Toxoplasmosis_Homo sapiens_hsa051450.48249686
82Arginine biosynthesis_Homo sapiens_hsa002200.45184493
83Sphingolipid metabolism_Homo sapiens_hsa006000.44814554
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43948189
85Melanoma_Homo sapiens_hsa052180.43749230
86ErbB signaling pathway_Homo sapiens_hsa040120.42446857
87Tuberculosis_Homo sapiens_hsa051520.40886280
88Prolactin signaling pathway_Homo sapiens_hsa049170.40545917
89Olfactory transduction_Homo sapiens_hsa047400.40146906
90Fatty acid biosynthesis_Homo sapiens_hsa000610.40062686
91Oxytocin signaling pathway_Homo sapiens_hsa049210.39946676
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39848995
93Pathways in cancer_Homo sapiens_hsa052000.39247035
94Chronic myeloid leukemia_Homo sapiens_hsa052200.35534773
95Pancreatic cancer_Homo sapiens_hsa052120.34820729
96Dopaminergic synapse_Homo sapiens_hsa047280.33711860
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31629528
98MAPK signaling pathway_Homo sapiens_hsa040100.30172206
99Complement and coagulation cascades_Homo sapiens_hsa046100.29567215
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29276974

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