ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adhesion of symbiont to host cell (GO:0044650)	9.86910609
2	virion attachment to host cell (GO:0019062)	9.86910609
3	citrulline biosynthetic process (GO:0019240)	8.90034358
4	peptide cross-linking (GO:0018149)	8.47965981
5	hair follicle morphogenesis (GO:0031069)	8.41150540
6	adhesion of symbiont to host (GO:0044406)	8.32353103
7	intermediate filament cytoskeleton organization (GO:0045104)	6.73379030
8	intermediate filament-based process (GO:0045103)	6.51826835
9	epidermis development (GO:0008544)	6.20610286
10	cell wall macromolecule metabolic process (GO:0044036)	6.03433649
11	cell wall macromolecule catabolic process (GO:0016998)	6.03433649
12	citrulline metabolic process (GO:0000052)	5.89298533
13	establishment of skin barrier (GO:0061436)	5.74643942
14	keratinocyte differentiation (GO:0030216)	5.73995612
15	hair cycle process (GO:0022405)	5.39989786
16	molting cycle process (GO:0022404)	5.39989786
17	regulation of water loss via skin (GO:0033561)	5.10506050
18	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.97605704
19	peptidyl-arginine modification (GO:0018195)	4.92242360
20	hemidesmosome assembly (GO:0031581)	4.78725474
21	skin morphogenesis (GO:0043589)	4.65218478
22	epidermal cell differentiation (GO:0009913)	4.47605772
23	molting cycle (GO:0042303)	34.9304848
24	hair cycle (GO:0042633)	34.9304848
25	keratinocyte development (GO:0003334)	3.83349648
26	tooth mineralization (GO:0034505)	3.80196782
27	multicellular organismal water homeostasis (GO:0050891)	3.42702218
28	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.37811430
29	regulation of keratinocyte differentiation (GO:0045616)	3.37134505
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.33450967
31	positive regulation of hair cycle (GO:0042635)	3.22259073
32	positive regulation of hair follicle development (GO:0051798)	3.22259073
33	hair follicle development (GO:0001942)	3.17974896
34	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.15109923
35	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.08987366
36	regulation of hair follicle development (GO:0051797)	2.99725204
37	bone trabecula formation (GO:0060346)	2.96499830
38	epithelium development (GO:0060429)	2.93776873
39	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.86289067
40	gap junction assembly (GO:0016264)	2.83035115
41	water homeostasis (GO:0030104)	2.80923689
42	positive regulation of meiotic cell cycle (GO:0051446)	2.79271997
43	regulation of hair cycle (GO:0042634)	2.70892631
44	positive regulation of epidermis development (GO:0045684)	2.69779992
45	regulation of epidermal cell differentiation (GO:0045604)	2.60985560
46	negative regulation of protein localization to plasma membrane (GO:1903077)	2.60939637
47	ectoderm development (GO:0007398)	2.58980110
48	fatty acid elongation (GO:0030497)	2.51387270
49	atrioventricular valve morphogenesis (GO:0003181)	2.50137724
50	regulation of epidermis development (GO:0045682)	2.49226057
51	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.46063405
52	phosphatidylserine metabolic process (GO:0006658)	2.33769749
53	ventricular cardiac muscle cell action potential (GO:0086005)	2.31153924
54	positive regulation of monocyte chemotaxis (GO:0090026)	2.27260226
55	wound healing, spreading of epidermal cells (GO:0035313)	2.26427117
56	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.26131596
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.21398427
58	positive regulation of epidermal cell differentiation (GO:0045606)	2.21351495
59	negative regulation of cell fate specification (GO:0009996)	2.20488870
60	cranial suture morphogenesis (GO:0060363)	2.18004153
61	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.16141546
62	skin development (GO:0043588)	2.10590603
63	aging (GO:0007568)	2.05937200
64	regulation of ruffle assembly (GO:1900027)	2.05931668
65	lymph vessel development (GO:0001945)	2.04107265
66	intermediate filament organization (GO:0045109)	12.2044336
67	keratinization (GO:0031424)	11.7686215
68	desmosome organization (GO:0002934)	10.0535728
69	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.99868813
70	negative regulation of epidermis development (GO:0045683)	1.99129414
71	epithelial cell-cell adhesion (GO:0090136)	1.96116668
72	regulation of cardioblast differentiation (GO:0051890)	1.94755385
73	regulation of heart rate by cardiac conduction (GO:0086091)	1.92680098
74	myotube differentiation (GO:0014902)	1.92663435
75	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.91890315
76	outflow tract septum morphogenesis (GO:0003148)	1.91800605
77	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.90346791
78	ephrin receptor signaling pathway (GO:0048013)	1.86979648
79	regulation of keratinocyte proliferation (GO:0010837)	1.86515703
80	cell communication involved in cardiac conduction (GO:0086065)	1.84360590
81	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.78084647
82	non-canonical Wnt signaling pathway (GO:0035567)	1.77777783
83	cell-substrate junction assembly (GO:0007044)	1.76068188
84	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.75080636
85	alditol phosphate metabolic process (GO:0052646)	1.72488714
86	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.70128471
87	primary alcohol catabolic process (GO:0034310)	1.64836924
88	regulation of monocyte chemotaxis (GO:0090025)	1.62361390
89	keratinocyte proliferation (GO:0043616)	1.62160117
90	very long-chain fatty acid metabolic process (GO:0000038)	1.61987772
91	negative regulation of epidermal cell differentiation (GO:0045605)	1.60907956
92	wound healing, spreading of cells (GO:0044319)	1.58511284
93	establishment of planar polarity (GO:0001736)	1.58298267
94	establishment of tissue polarity (GO:0007164)	1.58298267
95	response to UV-B (GO:0010224)	1.58066468
96	craniofacial suture morphogenesis (GO:0097094)	1.57314148
97	coronary vasculature morphogenesis (GO:0060977)	1.55728734
98	cellular modified amino acid biosynthetic process (GO:0042398)	1.55202821
99	cardiac right ventricle morphogenesis (GO:0003215)	1.54932444
100	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.54414017

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.27697170
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.05781430
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.60816509
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.66664088
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.39670890
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.15219914
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.12959556
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.5626295
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.87700288
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.86448966
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.86097086
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.76743179
13	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.75793688
14	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.75302798
15	EGR1_19032775_ChIP-ChIP_M12_Human	1.71821880
16	ERG_20517297_ChIP-Seq_VCAP_Human	1.68098404
17	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.67778658
18	P53_21459846_ChIP-Seq_SAOS-2_Human	1.63866261
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.61886795
20	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.55983054
21	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.54583335
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.54255722
23	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.54075077
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51891167
25	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.51150593
26	TP63_22573176_ChIP-Seq_HFKS_Human	1.50502285
27	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.49707786
28	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.49707786
29	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.49092671
30	LXR_22292898_ChIP-Seq_THP-1_Human	1.49038413
31	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.45323135
32	BCOR_27268052_Chip-Seq_Bcells_Human	1.45240365
33	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.38873440
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.37898976
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.37738468
36	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.37693602
37	ATF3_27146783_Chip-Seq_COLON_Human	1.36302521
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.29311868
39	PHF8_20622854_ChIP-Seq_HELA_Human	1.29003693
40	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27604358
41	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.26472807
42	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.25626615
43	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.25504130
44	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.25264860
45	AHR_22903824_ChIP-Seq_MCF-7_Human	1.24364489
46	P68_20966046_ChIP-Seq_HELA_Human	1.24032362
47	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21734247
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.19813057
49	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.19421439
50	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.18856556
51	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17866006
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.17758793
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16874381
54	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.14123648
55	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.12886314
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.12375156
57	TP63_23658742_ChIP-Seq_EP156T_Human	1.11364309
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10216934
59	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.09866632
60	SMC4_20622854_ChIP-Seq_HELA_Human	1.08445786
61	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07135178
62	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06556545
63	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06045695
64	SOX2_21211035_ChIP-Seq_LN229_Human	1.05934064
65	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.05399108
66	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.04171698
67	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03553069
68	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.02898949
69	SPI1_20517297_ChIP-Seq_HL60_Human	1.02659810
70	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01185254
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99614250
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98578926
73	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.98450503
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96432249
75	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.96123918
76	KLF5_25053715_ChIP-Seq_YYC3_Human	0.95161901
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94278671
78	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.92029214
79	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.91822340
80	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.91598012
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90962110
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89438590
83	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.88362017
84	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88152814
85	RXR_22108803_ChIP-Seq_LS180_Human	0.87007391
86	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86270390
87	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.84647715
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.82474248
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.80251215
90	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.79644081
91	ZNF263_19887448_ChIP-Seq_K562_Human	0.78622372
92	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78080797
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.77925914
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.76440564
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.75309849
96	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.75049901
97	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74760861
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.74750416
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.74750416
100	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.73779363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.54654046
2	MP0002098_abnormal_vibrissa_morphology	7.29311998
3	MP0000647_abnormal_sebaceous_gland	6.47842654
4	MP0002796_impaired_skin_barrier	5.89522370
5	MP0010234_abnormal_vibrissa_follicle	5.16542832
6	MP0005275_abnormal_skin_tensile	5.12132868
7	MP0000383_abnormal_hair_follicle	4.53913814
8	MP0000377_abnormal_hair_follicle	4.08684257
9	MP0010678_abnormal_skin_adnexa	4.03505212
10	MP0003705_abnormal_hypodermis_morpholog	3.74202815
11	MP0005501_abnormal_skin_physiology	3.68624735
12	MP0000427_abnormal_hair_cycle	3.46955554
13	MP0002254_reproductive_system_inflammat	3.14580008
14	MP0001216_abnormal_epidermal_layer	2.66469456
15	MP0004381_abnormal_hair_follicle	2.45825292
16	MP0000367_abnormal_coat/_hair	2.39916989
17	MP0010771_integument_phenotype	2.31172452
18	MP0004947_skin_inflammation	2.27677528
19	MP0002060_abnormal_skin_morphology	2.19939098
20	MP0003453_abnormal_keratinocyte_physiol	2.17231380
21	MP0001243_abnormal_dermal_layer	2.14387548
22	MP0002234_abnormal_pharynx_morphology	2.00011658
23	MP0000467_abnormal_esophagus_morphology	1.70413569
24	MP0009053_abnormal_anal_canal	1.53959958
25	MP0009931_abnormal_skin_appearance	1.51568453
26	MP0000762_abnormal_tongue_morphology	1.47657925
27	MP0003566_abnormal_cell_adhesion	1.45308500
28	MP0003941_abnormal_skin_development	1.24473593
29	MP0005409_darkened_coat_color	1.19245853
30	MP0004885_abnormal_endolymph	0.99435627
31	MP0001191_abnormal_skin_condition	0.98900276
32	MP0004185_abnormal_adipocyte_glucose	0.95238108
33	MP0004264_abnormal_extraembryonic_tissu	0.90591578
34	MP0008438_abnormal_cutaneous_collagen	0.80429381
35	MP0002095_abnormal_skin_pigmentation	0.78516854
36	MP0001851_eye_inflammation	0.76664045
37	MP0003315_abnormal_perineum_morphology	0.70207581
38	MP0002877_abnormal_melanocyte_morpholog	0.65585031
39	MP0001346_abnormal_lacrimal_gland	0.64601696
40	MP0001849_ear_inflammation	0.63763613
41	MP0001340_abnormal_eyelid_morphology	0.63703644
42	MP0010030_abnormal_orbit_morphology	0.61676896
43	MP0000566_synostosis	0.60460320
44	MP0001661_extended_life_span	0.57784411
45	MP0003191_abnormal_cellular_cholesterol	0.57081928
46	MP0000627_abnormal_mammary_gland	0.56694595
47	MP0002282_abnormal_trachea_morphology	0.49746505
48	MP0005023_abnormal_wound_healing	0.48322524
49	MP0005451_abnormal_body_composition	0.48289143
50	MP0003755_abnormal_palate_morphology	0.48121000
51	MP0002970_abnormal_white_adipose	0.46716305
52	MP0001784_abnormal_fluid_regulation	0.44250512
53	MP0002111_abnormal_tail_morphology	0.40699182
54	MP0010352_gastrointestinal_tract_polyps	0.35949324
55	MP0002249_abnormal_larynx_morphology	0.35176779
56	MP0009840_abnormal_foam_cell	0.32576238
57	MP0004272_abnormal_basement_membrane	0.32514095
58	MP0009379_abnormal_foot_pigmentation	0.32348180
59	MP0000537_abnormal_urethra_morphology	0.31803377
60	MP0003385_abnormal_body_wall	0.31637375
61	MP0005075_abnormal_melanosome_morpholog	0.31293752
62	MP0002177_abnormal_outer_ear	0.28776969
63	MP0000678_abnormal_parathyroid_gland	0.28646259
64	MP0003329_amyloid_beta_deposits	0.26858350
65	MP0003763_abnormal_thymus_physiology	0.25537162
66	MP0003950_abnormal_plasma_membrane	0.25348272
67	MP0000465_gastrointestinal_hemorrhage	0.23601779
68	MP0002697_abnormal_eye_size	0.23450051
69	MP0005248_abnormal_Harderian_gland	0.21638792
70	MP0006054_spinal_hemorrhage	0.20006434
71	MP0004019_abnormal_vitamin_homeostasis	0.18791715
72	MP0003300_gastrointestinal_ulcer	0.18617763
73	MP0000432_abnormal_head_morphology	0.17692978
74	MP0005666_abnormal_adipose_tissue	0.17364230
75	MP0003638_abnormal_response/metabolism_	0.15756190
76	MP0003448_altered_tumor_morphology	0.15285573
77	MP0000604_amyloidosis	0.15214821
78	MP0004742_abnormal_vestibular_system	0.15201202
79	MP0003935_abnormal_craniofacial_develop	0.14961069
80	MP0005375_adipose_tissue_phenotype	0.14288796
81	MP0001879_abnormal_lymphatic_vessel	0.13545501
82	MP0004858_abnormal_nervous_system	0.13403644
83	MP0002166_altered_tumor_susceptibility	0.11876297
84	MP0002006_tumorigenesis	0.11862669
85	MP0003075_altered_response_to	0.10974567
86	MP0005367_renal/urinary_system_phenotyp	0.10955345
87	MP0000516_abnormal_urinary_system	0.10955345
88	MP0005076_abnormal_cell_differentiation	0.10424809
89	MP0003011_delayed_dark_adaptation	0.10283525
90	MP0000751_myopathy	0.09642086
91	MP0001958_emphysema	0.09452725
92	MP0009384_cardiac_valve_regurgitation	0.09253092
93	MP0002233_abnormal_nose_morphology	0.09121749
94	MP0003045_fibrosis	0.08829803
95	MP0005193_abnormal_anterior_eye	0.08023116
96	MP0000013_abnormal_adipose_tissue	0.06960523
97	MP0000733_abnormal_muscle_development	0.06871553
98	MP0006138_congestive_heart_failure	0.06860370
99	MP0008569_lethality_at_weaning	0.06324605
100	MP0010368_abnormal_lymphatic_system	0.05587590

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.75825918
2	Nail dystrophy (HP:0008404)	7.55509541
3	Abnormality of nail color (HP:0100643)	5.98817431
4	Abnormal hair laboratory examination (HP:0003328)	5.53627743
5	Fragile nails (HP:0001808)	5.50463409
6	Fine hair (HP:0002213)	5.44886479
7	Alopecia of scalp (HP:0002293)	4.82209017
8	Palmoplantar hyperkeratosis (HP:0000972)	4.67314931
9	Onycholysis (HP:0001806)	4.52287812
10	Palmar hyperkeratosis (HP:0010765)	4.39519763
11	Thick nail (HP:0001805)	4.30958775
12	Plantar hyperkeratosis (HP:0007556)	4.25924970
13	Increased IgE level (HP:0003212)	4.21411329
14	Follicular hyperkeratosis (HP:0007502)	4.09082313
15	Right ventricular cardiomyopathy (HP:0011663)	4.07471563
16	Sparse eyelashes (HP:0000653)	3.46955425
17	Erythema (HP:0010783)	3.35110647
18	Oral leukoplakia (HP:0002745)	3.24059804
19	Abnormality of the frontal sinuses (HP:0002687)	3.14160632
20	Milia (HP:0001056)	3.08517181
21	Parakeratosis (HP:0001036)	3.07814163
22	Amelogenesis imperfecta (HP:0000705)	3.06133377
23	Erythroderma (HP:0001019)	2.89429859
24	Curly hair (HP:0002212)	2.69048353
25	Intention tremor (HP:0002080)	2.60423677
26	Ridged nail (HP:0001807)	2.59853560
27	Congenital ichthyosiform erythroderma (HP:0007431)	2.56809609
28	Congenital, generalized hypertrichosis (HP:0004540)	2.53694186
29	Neck muscle weakness (HP:0000467)	2.47089358
30	Dry hair (HP:0011359)	2.45014017
31	Aplasia cutis congenita (HP:0001057)	2.44120614
32	Torticollis (HP:0000473)	2.36003682
33	Abnormal blistering of the skin (HP:0008066)	2.30560237
34	Natal tooth (HP:0000695)	2.29197737
35	Advanced eruption of teeth (HP:0006288)	2.19173133
36	Corneal erosion (HP:0200020)	2.09665215
37	Hypohidrosis (HP:0000966)	2.08437313
38	Craniofacial dystonia (HP:0012179)	2.00008737
39	Hypotrichosis (HP:0001006)	15.1741558
40	Abnormality of hair growth rate (HP:0011363)	11.5585280
41	Slow-growing hair (HP:0002217)	11.5585280
42	Woolly hair (HP:0002224)	11.0351748
43	Brittle hair (HP:0002299)	10.7826901
44	Palmoplantar keratoderma (HP:0000982)	1.99887609
45	Ventricular tachycardia (HP:0004756)	1.95359487
46	Pruritus (HP:0000989)	1.87270082
47	Difficulty walking (HP:0002355)	1.86633818
48	Abnormality of the pupil (HP:0000615)	1.86226339
49	Concave nail (HP:0001598)	1.84562745
50	Focal dystonia (HP:0004373)	1.83040240
51	Abnormality of the parietal bone (HP:0002696)	1.77553138
52	Abnormality of dental color (HP:0011073)	1.76903695
53	Abnormality of the dental root (HP:0006486)	1.76254091
54	Taurodontia (HP:0000679)	1.76254091
55	Abnormality of permanent molar morphology (HP:0011071)	1.76254091
56	Ventricular fibrillation (HP:0001663)	1.73596711
57	Abnormality of molar (HP:0011077)	1.73364501
58	Abnormality of molar morphology (HP:0011070)	1.73364501
59	Widely patent fontanelles and sutures (HP:0004492)	1.70178271
60	Hyporeflexia of lower limbs (HP:0002600)	1.65811409
61	Absent eyelashes (HP:0000561)	1.64026232
62	Recurrent corneal erosions (HP:0000495)	1.62588486
63	Conjunctival hamartoma (HP:0100780)	1.56260604
64	Abnormality of the neuromuscular junction (HP:0003398)	1.55863297
65	Fatigable weakness (HP:0003473)	1.55863297
66	Abnormality of the dental pulp (HP:0006479)	1.53988605
67	Blepharitis (HP:0000498)	1.52942897
68	Amniotic constriction ring (HP:0009775)	1.48604937
69	Abnormality of placental membranes (HP:0011409)	1.48604937
70	Sudden death (HP:0001699)	1.46190951
71	Heterogeneous (HP:0001425)	1.46098728
72	Acanthosis nigricans (HP:0000956)	1.44799364
73	Unilateral renal agenesis (HP:0000122)	1.40587329
74	Lip pit (HP:0100267)	1.39975100
75	Abnormality of the aortic arch (HP:0012303)	1.39770382
76	Keratoconjunctivitis sicca (HP:0001097)	1.39657506
77	Distal lower limb muscle weakness (HP:0009053)	1.37508443
78	Achilles tendon contracture (HP:0001771)	1.37421438
79	Carious teeth (HP:0000670)	1.35445213
80	Autoamputation (HP:0001218)	1.32723436
81	Gangrene (HP:0100758)	1.32371181
82	Ectropion (HP:0000656)	1.32359892
83	Round ear (HP:0100830)	1.31818295
84	Craniofacial hyperostosis (HP:0004493)	1.31395781
85	Abnormality of the Achilles tendon (HP:0005109)	1.29573012
86	Anonychia (HP:0001798)	1.27070769
87	Variable expressivity (HP:0003828)	1.25128911
88	Abnormality of the fingernails (HP:0001231)	1.23578899
89	Keratoconjunctivitis (HP:0001096)	1.22742679
90	Hypergammaglobulinemia (HP:0010702)	1.21989515
91	Neonatal onset (HP:0003623)	1.21777921
92	Lack of skin elasticity (HP:0100679)	1.18648656
93	Atrophic scars (HP:0001075)	1.17311915
94	Type 1 muscle fiber predominance (HP:0003803)	1.16413808
95	Increased connective tissue (HP:0009025)	1.15932363
96	Widely spaced teeth (HP:0000687)	1.15340382
97	Selective tooth agenesis (HP:0001592)	1.14827262
98	Sparse scalp hair (HP:0002209)	1.11258110
99	Bronchomalacia (HP:0002780)	1.09876016
100	Wide cranial sutures (HP:0010537)	1.08394762

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.41882254
2	MAPKAPK3	4.20182869
3	FER	3.93053426
4	ERN1	3.88192526
5	MAP3K6	3.55413567
6	EPHB2	3.10507122
7	TAOK1	3.00704215
8	MAP3K3	2.80073158
9	TRIB3	2.68335488
10	LATS1	2.46646950
11	MAP3K2	2.40945120
12	MAP3K11	2.04620332
13	RPS6KB2	2.02266121
14	TTN	1.85138966
15	PIK3CG	1.84896688
16	MAP2K6	1.84786328
17	EEF2K	1.74881934
18	LATS2	1.65913075
19	EPHB1	1.60093113
20	NME1	1.47962094
21	FGFR2	1.38906152
22	BCR	1.35760435
23	MAP3K1	1.29646292
24	KSR2	1.26284347
25	FGFR4	1.23930754
26	RIPK1	1.23434674
27	MAP2K3	1.21355704
28	MST1R	1.19829726
29	BMX	1.17676760
30	PKN2	1.16863539
31	CDK6	1.15606161
32	BLK	1.13219740
33	FGFR1	1.12474225
34	LRRK2	1.06035707
35	MAPKAPK2	1.05768204
36	FGFR3	1.04509696
37	PDGFRA	1.03466469
38	PBK	1.03146380
39	PTK6	0.99907500
40	MAP3K7	0.99142884
41	MAP3K9	0.92953405
42	MAP2K4	0.87522099
43	RPS6KA4	0.81799238
44	MAP2K1	0.81068035
45	SIK1	0.79731494
46	STK38	0.79320370
47	PTK2	0.77563180
48	PIM2	0.75727734
49	TESK1	0.71500299
50	STK38L	0.71100770
51	PAK3	0.70318399
52	PAK4	0.70120139
53	PRKD1	0.69598211
54	DDR2	0.68852855
55	DYRK1B	0.68431119
56	CDK19	0.67972610
57	MET	0.67870874
58	ERBB4	0.60165162
59	NTRK2	0.58223650
60	MAP3K5	0.56901915
61	PRKCI	0.55872660
62	TGFBR1	0.55432286
63	TRPM7	0.54994204
64	TYRO3	0.54620684
65	PRKCH	0.54378519
66	MAP3K10	0.52753130
67	NEK1	0.51770328
68	RET	0.51398396
69	ALK	0.49537794
70	PAK6	0.49054531
71	JAK1	0.47129564
72	ERBB2	0.46710832
73	PAK2	0.44993954
74	MAPK12	0.44832480
75	OBSCN	0.43926822
76	RPS6KA1	0.42965630
77	EPHA3	0.42421171
78	MST4	0.41963336
79	GSK3A	0.41505243
80	TYK2	0.41205924
81	ERBB3	0.41120654
82	CSNK1E	0.40625223
83	MAP2K2	0.39826455
84	JAK2	0.37216667
85	ILK	0.36650054
86	LIMK1	0.34833371
87	PHKG1	0.31210472
88	PHKG2	0.31210472
89	GRK6	0.30607773
90	MAP3K8	0.28862314
91	FYN	0.28330865
92	SRC	0.24889761
93	CSNK1A1	0.24425159
94	ROCK2	0.24346255
95	HCK	0.23000592
96	TGFBR2	0.22990417
97	PRKACG	0.22030192
98	CSNK1D	0.21975900
99	CLK1	0.21665968
100	STK11	0.21448757

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.91084191
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.87680076
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.15531949
4	Fatty acid elongation_Homo sapiens_hsa00062	2.68266129
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.57396883
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.16600841
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.88389746
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.81168927
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.78887992
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.73820859
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.73372604
12	Melanogenesis_Homo sapiens_hsa04916	1.57936697
13	Axon guidance_Homo sapiens_hsa04360	1.52902348
14	Histidine metabolism_Homo sapiens_hsa00340	1.38338312
15	Bladder cancer_Homo sapiens_hsa05219	1.36555137
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.35127589
17	Glioma_Homo sapiens_hsa05214	1.33713978
18	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.31130848
19	Thyroid cancer_Homo sapiens_hsa05216	1.30922920
20	Caffeine metabolism_Homo sapiens_hsa00232	1.29770289
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.27792051
22	GnRH signaling pathway_Homo sapiens_hsa04912	1.24992624
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.22939454
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.18237150
25	Pancreatic secretion_Homo sapiens_hsa04972	1.11949082
26	Acute myeloid leukemia_Homo sapiens_hsa05221	1.11875797
27	Tight junction_Homo sapiens_hsa04530	1.11870917
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.09427377
29	Mineral absorption_Homo sapiens_hsa04978	1.06818684
30	Long-term potentiation_Homo sapiens_hsa04720	1.05650845
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.05644550
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.03729522
33	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00293959
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97933946
35	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.93629252
36	ECM-receptor interaction_Homo sapiens_hsa04512	0.92855178
37	Adherens junction_Homo sapiens_hsa04520	0.90707060
38	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.90467193
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.88342540
40	Pertussis_Homo sapiens_hsa05133	0.87818679
41	Non-small cell lung cancer_Homo sapiens_hsa05223	0.87067400
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.86571624
43	Endometrial cancer_Homo sapiens_hsa05213	0.85046173
44	Long-term depression_Homo sapiens_hsa04730	0.84693396
45	Ras signaling pathway_Homo sapiens_hsa04014	0.82414327
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82166873
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.79086356
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78830475
49	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76589257
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.75993963
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.75160970
52	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74762431
53	Amoebiasis_Homo sapiens_hsa05146	0.74232251
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.71255450
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.69951584
56	Gastric acid secretion_Homo sapiens_hsa04971	0.68084045
57	Renin secretion_Homo sapiens_hsa04924	0.66963592
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65063905
59	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.64689742
60	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.61916710
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.60770503
62	MicroRNAs in cancer_Homo sapiens_hsa05206	0.60663639
63	Insulin resistance_Homo sapiens_hsa04931	0.58181159
64	Phototransduction_Homo sapiens_hsa04744	0.57518141
65	Hepatitis C_Homo sapiens_hsa05160	0.57082950
66	Gap junction_Homo sapiens_hsa04540	0.56596996
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.56432793
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.55895766
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54234096
70	Salmonella infection_Homo sapiens_hsa05132	0.53774056
71	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.50799491
72	Butanoate metabolism_Homo sapiens_hsa00650	0.49663178
73	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49320150
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48902700
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.48886881
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.48845123
77	Focal adhesion_Homo sapiens_hsa04510	0.48621256
78	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48431960
79	Platelet activation_Homo sapiens_hsa04611	0.47961280
80	Fatty acid degradation_Homo sapiens_hsa00071	0.47441299
81	Salivary secretion_Homo sapiens_hsa04970	0.47401066
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.47305655
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.45720539
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44041679
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.43418619
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42381784
87	Prion diseases_Homo sapiens_hsa05020	0.42053059
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41856644
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41809200
90	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.39143597
91	Tuberculosis_Homo sapiens_hsa05152	0.37993180
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.37986043
93	p53 signaling pathway_Homo sapiens_hsa04115	0.37254543
94	Olfactory transduction_Homo sapiens_hsa04740	0.36636918
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.36016320
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.36010817
97	Toxoplasmosis_Homo sapiens_hsa05145	0.34917801
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.34591428
99	Insulin signaling pathway_Homo sapiens_hsa04910	0.33187441
100	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.31663619

KRTAP7-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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