ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	virion attachment to host cell (GO:0019062)	9.80643043
2	adhesion of symbiont to host cell (GO:0044650)	9.80643043
3	citrulline biosynthetic process (GO:0019240)	8.84160303
4	peptide cross-linking (GO:0018149)	8.52636032
5	hair follicle morphogenesis (GO:0031069)	8.39169028
6	adhesion of symbiont to host (GO:0044406)	8.26415767
7	intermediate filament cytoskeleton organization (GO:0045104)	6.77181173
8	intermediate filament-based process (GO:0045103)	6.55468969
9	epidermis development (GO:0008544)	6.24593190
10	cell wall macromolecule metabolic process (GO:0044036)	6.10137581
11	cell wall macromolecule catabolic process (GO:0016998)	6.10137581
12	citrulline metabolic process (GO:0000052)	5.84918606
13	keratinocyte differentiation (GO:0030216)	5.79928986
14	establishment of skin barrier (GO:0061436)	5.74920824
15	hair cycle process (GO:0022405)	5.41962519
16	molting cycle process (GO:0022404)	5.41962519
17	regulation of water loss via skin (GO:0033561)	5.11331054
18	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.98802947
19	peptidyl-arginine modification (GO:0018195)	4.89046403
20	hemidesmosome assembly (GO:0031581)	4.81882766
21	skin morphogenesis (GO:0043589)	4.61633957
22	epidermal cell differentiation (GO:0009913)	4.52466870
23	molting cycle (GO:0042303)	34.7270687
24	hair cycle (GO:0042633)	34.7270687
25	keratinocyte development (GO:0003334)	3.86993241
26	tooth mineralization (GO:0034505)	3.80727335
27	multicellular organismal water homeostasis (GO:0050891)	3.43199403
28	regulation of keratinocyte differentiation (GO:0045616)	3.42432292
29	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.36898453
30	negative regulation of keratinocyte proliferation (GO:0010839)	3.36136541
31	positive regulation of hair cycle (GO:0042635)	3.24769774
32	positive regulation of hair follicle development (GO:0051798)	3.24769774
33	hair follicle development (GO:0001942)	3.22864332
34	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.13835300
35	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.07573449
36	regulation of hair follicle development (GO:0051797)	3.01712394
37	bone trabecula formation (GO:0060346)	2.98756473
38	epithelium development (GO:0060429)	2.95728521
39	gap junction assembly (GO:0016264)	2.90429153
40	positive regulation of meiotic cell cycle (GO:0051446)	2.84916243
41	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.84680351
42	water homeostasis (GO:0030104)	2.81332785
43	regulation of hair cycle (GO:0042634)	2.75214117
44	positive regulation of epidermis development (GO:0045684)	2.71187618
45	regulation of epidermal cell differentiation (GO:0045604)	2.64514936
46	ectoderm development (GO:0007398)	2.63260372
47	negative regulation of protein localization to plasma membrane (GO:1903077)	2.60025446
48	fatty acid elongation (GO:0030497)	2.55754434
49	regulation of epidermis development (GO:0045682)	2.51700218
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.51022761
51	atrioventricular valve morphogenesis (GO:0003181)	2.48342515
52	phosphatidylserine metabolic process (GO:0006658)	2.32786437
53	positive regulation of monocyte chemotaxis (GO:0090026)	2.32419272
54	ventricular cardiac muscle cell action potential (GO:0086005)	2.30906586
55	wound healing, spreading of epidermal cells (GO:0035313)	2.28711008
56	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.25516498
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.24727609
58	cranial suture morphogenesis (GO:0060363)	2.23637685
59	positive regulation of epidermal cell differentiation (GO:0045606)	2.22783359
60	negative regulation of cell fate specification (GO:0009996)	2.19245086
61	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.16742298
62	regulation of ruffle assembly (GO:1900027)	2.08633562
63	skin development (GO:0043588)	2.08420106
64	aging (GO:0007568)	2.03958371
65	negative regulation of epidermis development (GO:0045683)	2.02859550
66	lymph vessel development (GO:0001945)	2.02046279
67	intermediate filament organization (GO:0045109)	12.2050780
68	keratinization (GO:0031424)	11.9257411
69	desmosome organization (GO:0002934)	10.1417766
70	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.99144703
71	epithelial cell-cell adhesion (GO:0090136)	1.95744302
72	regulation of cardioblast differentiation (GO:0051890)	1.93578420
73	regulation of heart rate by cardiac conduction (GO:0086091)	1.92657434
74	outflow tract septum morphogenesis (GO:0003148)	1.92215505
75	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.91975803
76	myotube differentiation (GO:0014902)	1.91262813
77	cytoskeletal anchoring at plasma membrane (GO:0007016)	1.90675887
78	ephrin receptor signaling pathway (GO:0048013)	1.88450741
79	regulation of keratinocyte proliferation (GO:0010837)	1.88355820
80	cell communication involved in cardiac conduction (GO:0086065)	1.84927882
81	non-canonical Wnt signaling pathway (GO:0035567)	1.79693643
82	cell-substrate junction assembly (GO:0007044)	1.76686957
83	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.76648101
84	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	1.76476853
85	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	1.74641007
86	alditol phosphate metabolic process (GO:0052646)	1.71501720
87	primary alcohol catabolic process (GO:0034310)	1.65922959
88	regulation of monocyte chemotaxis (GO:0090025)	1.65737596
89	negative regulation of epidermal cell differentiation (GO:0045605)	1.65586615
90	very long-chain fatty acid metabolic process (GO:0000038)	1.64829747
91	establishment of tissue polarity (GO:0007164)	1.60836695
92	establishment of planar polarity (GO:0001736)	1.60836695
93	craniofacial suture morphogenesis (GO:0097094)	1.60706986
94	wound healing, spreading of cells (GO:0044319)	1.59791585
95	response to UV-B (GO:0010224)	1.59147943
96	keratinocyte proliferation (GO:0043616)	1.57396854
97	eyelid development in camera-type eye (GO:0061029)	1.55704343
98	cardiac right ventricle morphogenesis (GO:0003215)	1.55655003
99	positive regulation of protein export from nucleus (GO:0046827)	1.55502227
100	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.55260173

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.16234466
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	5.10453591
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.62984290
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.73933633
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.38744782
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.12777858
7	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	2.09780414
8	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.6550873
9	TAF2_19829295_ChIP-Seq_ESCs_Human	1.85757436
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.85431369
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.83873041
12	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.76897676
13	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.74684777
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.74660087
15	EGR1_19032775_ChIP-ChIP_M12_Human	1.73182070
16	NANOG_20526341_ChIP-Seq_ESCs_Human	1.72266077
17	ERG_20517297_ChIP-Seq_VCAP_Human	1.69644171
18	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.68556782
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.61094625
20	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.55994032
21	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.54122280
22	BCL6_27268052_Chip-Seq_Bcells_Human	1.53935164
23	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51990310
24	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.51161973
25	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.51161973
26	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.50420739
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.50001913
28	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.48158726
29	LXR_22292898_ChIP-Seq_THP-1_Human	1.47105370
30	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.46908375
31	BCOR_27268052_Chip-Seq_Bcells_Human	1.45012670
32	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.43999826
33	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40175432
34	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38663315
35	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.38208698
36	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.37273961
37	ATF3_27146783_Chip-Seq_COLON_Human	1.35825055
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.31279183
39	PHF8_20622854_ChIP-Seq_HELA_Human	1.28117430
40	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.27688292
41	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27150077
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.25846341
43	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.25821410
44	AHR_22903824_ChIP-Seq_MCF-7_Human	1.25194819
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.24971092
46	P68_20966046_ChIP-Seq_HELA_Human	1.23502819
47	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21825298
48	CEBPB_22108803_ChIP-Seq_LS180_Human	1.20920628
49	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.20293383
50	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.19404373
51	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.18529743
52	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17728753
53	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.16878809
54	TP63_23658742_ChIP-Seq_EP156T_Human	1.13405367
55	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.12727092
56	RAC3_21632823_ChIP-Seq_H3396_Human	1.11723209
57	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.11132706
58	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.10637690
59	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08368894
60	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07832445
61	SMC4_20622854_ChIP-Seq_HELA_Human	1.06752949
62	GATA4_25053715_ChIP-Seq_YYC3_Human	1.06668237
63	SOX2_21211035_ChIP-Seq_LN229_Human	1.05927120
64	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.05702218
65	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.04829801
66	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04404972
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.03970567
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02729608
69	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.01848158
70	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.00493778
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98616274
72	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.97958523
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.96033521
74	KLF5_25053715_ChIP-Seq_YYC3_Human	0.95301245
75	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.93975410
76	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93879751
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92020471
78	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91073873
79	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.90784869
80	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90656681
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.90137173
82	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.89747834
83	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88388741
84	RXR_22108803_ChIP-Seq_LS180_Human	0.88012284
85	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.86787724
86	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.86334171
87	SOX2_20726797_ChIP-Seq_SW620_Human	0.83459072
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.79960189
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.79837756
90	ZNF263_19887448_ChIP-Seq_K562_Human	0.79803870
91	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78034462
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.77385974
93	AR_21572438_ChIP-Seq_LNCaP_Human	0.77357178
94	* SPI1_20517297_ChIP-Seq_HL60_Human	0.75798256
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.75608957
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.75608957
97	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.74857850
98	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.74610957
99	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74130285
100	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.73049573

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.57150809
2	MP0002098_abnormal_vibrissa_morphology	7.25271246
3	MP0000647_abnormal_sebaceous_gland	6.44379038
4	MP0002796_impaired_skin_barrier	5.90784794
5	MP0010234_abnormal_vibrissa_follicle	5.13577558
6	MP0005275_abnormal_skin_tensile	5.11681658
7	MP0000383_abnormal_hair_follicle	4.61374754
8	MP0010678_abnormal_skin_adnexa	4.09455836
9	MP0000377_abnormal_hair_follicle	4.07653143
10	MP0003705_abnormal_hypodermis_morpholog	3.69235918
11	MP0005501_abnormal_skin_physiology	3.68605436
12	MP0000427_abnormal_hair_cycle	3.48937368
13	MP0002254_reproductive_system_inflammat	3.17846303
14	MP0001216_abnormal_epidermal_layer	2.66896345
15	MP0004381_abnormal_hair_follicle	2.44801212
16	MP0000367_abnormal_coat/_hair	2.39443457
17	MP0010771_integument_phenotype	2.31843137
18	MP0004947_skin_inflammation	2.28634731
19	MP0002060_abnormal_skin_morphology	2.18848104
20	MP0003453_abnormal_keratinocyte_physiol	2.18064861
21	MP0001243_abnormal_dermal_layer	2.13713373
22	MP0002234_abnormal_pharynx_morphology	1.96404632
23	MP0000467_abnormal_esophagus_morphology	1.72256915
24	MP0009053_abnormal_anal_canal	1.53800070
25	MP0009931_abnormal_skin_appearance	1.51451346
26	MP0000762_abnormal_tongue_morphology	1.48476788
27	MP0003566_abnormal_cell_adhesion	1.44720120
28	MP0003941_abnormal_skin_development	1.26397329
29	MP0005409_darkened_coat_color	1.20773062
30	MP0004885_abnormal_endolymph	1.01320658
31	MP0001191_abnormal_skin_condition	0.99590385
32	MP0004185_abnormal_adipocyte_glucose	0.97391725
33	MP0004264_abnormal_extraembryonic_tissu	0.93317336
34	MP0002095_abnormal_skin_pigmentation	0.78376827
35	MP0001851_eye_inflammation	0.75511609
36	MP0008438_abnormal_cutaneous_collagen	0.73613771
37	MP0003315_abnormal_perineum_morphology	0.69713510
38	MP0001346_abnormal_lacrimal_gland	0.66876514
39	MP0002877_abnormal_melanocyte_morpholog	0.66331009
40	MP0001340_abnormal_eyelid_morphology	0.64340203
41	MP0001661_extended_life_span	0.62709487
42	MP0000566_synostosis	0.62671870
43	MP0001849_ear_inflammation	0.62385694
44	MP0010030_abnormal_orbit_morphology	0.61523903
45	MP0000627_abnormal_mammary_gland	0.56923168
46	MP0003191_abnormal_cellular_cholesterol	0.55297238
47	MP0002282_abnormal_trachea_morphology	0.49667918
48	MP0005023_abnormal_wound_healing	0.48460689
49	MP0003755_abnormal_palate_morphology	0.48268070
50	MP0005451_abnormal_body_composition	0.47997198
51	MP0002970_abnormal_white_adipose	0.46487954
52	MP0001784_abnormal_fluid_regulation	0.44618866
53	MP0002111_abnormal_tail_morphology	0.40761085
54	MP0010352_gastrointestinal_tract_polyps	0.36617323
55	MP0002249_abnormal_larynx_morphology	0.32932890
56	MP0000537_abnormal_urethra_morphology	0.32432127
57	MP0004272_abnormal_basement_membrane	0.32096750
58	MP0003385_abnormal_body_wall	0.31879652
59	MP0009840_abnormal_foam_cell	0.30840763
60	MP0005075_abnormal_melanosome_morpholog	0.30272792
61	MP0002177_abnormal_outer_ear	0.27323317
62	MP0000678_abnormal_parathyroid_gland	0.25971964
63	MP0003329_amyloid_beta_deposits	0.25948832
64	MP0003950_abnormal_plasma_membrane	0.25865507
65	MP0003763_abnormal_thymus_physiology	0.24915248
66	MP0002697_abnormal_eye_size	0.24137792
67	MP0000465_gastrointestinal_hemorrhage	0.23115230
68	MP0005248_abnormal_Harderian_gland	0.22558050
69	MP0006054_spinal_hemorrhage	0.19071679
70	MP0003300_gastrointestinal_ulcer	0.18587033
71	MP0005666_abnormal_adipose_tissue	0.18277243
72	MP0000432_abnormal_head_morphology	0.18206930
73	MP0004019_abnormal_vitamin_homeostasis	0.17838935
74	MP0009379_abnormal_foot_pigmentation	0.17623466
75	MP0003638_abnormal_response/metabolism_	0.15639329
76	MP0003935_abnormal_craniofacial_develop	0.15012084
77	MP0000604_amyloidosis	0.14813941
78	MP0004742_abnormal_vestibular_system	0.14536761
79	MP0003448_altered_tumor_morphology	0.14374031
80	MP0005375_adipose_tissue_phenotype	0.14245624
81	MP0002166_altered_tumor_susceptibility	0.13558795
82	MP0002006_tumorigenesis	0.12956937
83	MP0001879_abnormal_lymphatic_vessel	0.12671836
84	MP0004858_abnormal_nervous_system	0.12072326
85	MP0000516_abnormal_urinary_system	0.11463382
86	MP0005367_renal/urinary_system_phenotyp	0.11463382
87	MP0009384_cardiac_valve_regurgitation	0.11274348
88	MP0003075_altered_response_to	0.10602546
89	MP0005076_abnormal_cell_differentiation	0.10457282
90	MP0000751_myopathy	0.09010253
91	MP0003011_delayed_dark_adaptation	0.08913789
92	MP0002233_abnormal_nose_morphology	0.08411609
93	MP0005193_abnormal_anterior_eye	0.08364804
94	MP0003045_fibrosis	0.07232676
95	MP0001958_emphysema	0.06803884
96	MP0006138_congestive_heart_failure	0.06450005
97	MP0000733_abnormal_muscle_development	0.06120324
98	MP0000013_abnormal_adipose_tissue	0.06040228
99	MP0008569_lethality_at_weaning	0.05939393
100	MP0001730_embryonic_growth_arrest	0.05897824

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pili torti (HP:0003777)	8.80063730
2	Nail dystrophy (HP:0008404)	7.51808782
3	Abnormality of nail color (HP:0100643)	6.07216552
4	Abnormal hair laboratory examination (HP:0003328)	5.56431482
5	Fragile nails (HP:0001808)	5.53128876
6	Fine hair (HP:0002213)	5.43185461
7	Alopecia of scalp (HP:0002293)	4.81895386
8	Palmoplantar hyperkeratosis (HP:0000972)	4.70052757
9	Onycholysis (HP:0001806)	4.47734081
10	Palmar hyperkeratosis (HP:0010765)	4.42200429
11	Thick nail (HP:0001805)	4.32186051
12	Plantar hyperkeratosis (HP:0007556)	4.28043778
13	Increased IgE level (HP:0003212)	4.15997170
14	Follicular hyperkeratosis (HP:0007502)	4.15934872
15	Right ventricular cardiomyopathy (HP:0011663)	4.05763588
16	Sparse eyelashes (HP:0000653)	3.51074381
17	Erythema (HP:0010783)	3.37515088
18	Oral leukoplakia (HP:0002745)	3.31186460
19	Parakeratosis (HP:0001036)	3.17206136
20	Abnormality of the frontal sinuses (HP:0002687)	3.16961747
21	Milia (HP:0001056)	3.07375796
22	Amelogenesis imperfecta (HP:0000705)	3.06586193
23	Erythroderma (HP:0001019)	2.92616179
24	Curly hair (HP:0002212)	2.68396312
25	Congenital, generalized hypertrichosis (HP:0004540)	2.61920085
26	Intention tremor (HP:0002080)	2.61104302
27	Ridged nail (HP:0001807)	2.60517031
28	Congenital ichthyosiform erythroderma (HP:0007431)	2.52429230
29	Dry hair (HP:0011359)	2.48209469
30	Neck muscle weakness (HP:0000467)	2.47641002
31	Aplasia cutis congenita (HP:0001057)	2.46590357
32	Torticollis (HP:0000473)	2.33422772
33	Abnormal blistering of the skin (HP:0008066)	2.29386461
34	Natal tooth (HP:0000695)	2.26801300
35	Advanced eruption of teeth (HP:0006288)	2.16746774
36	Corneal erosion (HP:0200020)	2.10992965
37	Hypohidrosis (HP:0000966)	2.10377138
38	Palmoplantar keratoderma (HP:0000982)	2.01207314
39	Hypotrichosis (HP:0001006)	15.1024558
40	Abnormality of hair growth rate (HP:0011363)	11.5151247
41	Slow-growing hair (HP:0002217)	11.5151247
42	Woolly hair (HP:0002224)	11.0741668
43	Brittle hair (HP:0002299)	10.7204840
44	Craniofacial dystonia (HP:0012179)	1.97734332
45	Ventricular tachycardia (HP:0004756)	1.94997581
46	Pruritus (HP:0000989)	1.88492862
47	Concave nail (HP:0001598)	1.88390828
48	Difficulty walking (HP:0002355)	1.85922327
49	Abnormality of the pupil (HP:0000615)	1.84692459
50	Focal dystonia (HP:0004373)	1.80952263
51	Abnormality of the parietal bone (HP:0002696)	1.80005744
52	Abnormality of dental color (HP:0011073)	1.78512938
53	Abnormality of the dental root (HP:0006486)	1.77829748
54	Taurodontia (HP:0000679)	1.77829748
55	Abnormality of permanent molar morphology (HP:0011071)	1.77829748
56	Abnormality of molar morphology (HP:0011070)	1.74163000
57	Abnormality of molar (HP:0011077)	1.74163000
58	Ventricular fibrillation (HP:0001663)	1.72877234
59	Widely patent fontanelles and sutures (HP:0004492)	1.72255807
60	Absent eyelashes (HP:0000561)	1.68428681
61	Hyporeflexia of lower limbs (HP:0002600)	1.67852747
62	Recurrent corneal erosions (HP:0000495)	1.65223131
63	Conjunctival hamartoma (HP:0100780)	1.60258955
64	Abnormality of the dental pulp (HP:0006479)	1.55379332
65	Fatigable weakness (HP:0003473)	1.54769223
66	Abnormality of the neuromuscular junction (HP:0003398)	1.54769223
67	Blepharitis (HP:0000498)	1.53210083
68	Amniotic constriction ring (HP:0009775)	1.52342519
69	Abnormality of placental membranes (HP:0011409)	1.52342519
70	Acanthosis nigricans (HP:0000956)	1.45391681
71	Sudden death (HP:0001699)	1.45084073
72	Heterogeneous (HP:0001425)	1.44858709
73	Lip pit (HP:0100267)	1.43563671
74	Keratoconjunctivitis sicca (HP:0001097)	1.41197166
75	Distal lower limb muscle weakness (HP:0009053)	1.38468542
76	Unilateral renal agenesis (HP:0000122)	1.37015736
77	Achilles tendon contracture (HP:0001771)	1.36779866
78	Carious teeth (HP:0000670)	1.36488824
79	Abnormality of the aortic arch (HP:0012303)	1.35893320
80	Autoamputation (HP:0001218)	1.35849148
81	Round ear (HP:0100830)	1.34357304
82	Gangrene (HP:0100758)	1.33795467
83	Ectropion (HP:0000656)	1.32653683
84	Craniofacial hyperostosis (HP:0004493)	1.32303749
85	Abnormality of the Achilles tendon (HP:0005109)	1.29093963
86	Anonychia (HP:0001798)	1.27567214
87	Abnormality of the fingernails (HP:0001231)	1.24827195
88	Keratoconjunctivitis (HP:0001096)	1.24142623
89	Variable expressivity (HP:0003828)	1.23635424
90	Neonatal onset (HP:0003623)	1.21766086
91	Hypergammaglobulinemia (HP:0010702)	1.19507271
92	Lack of skin elasticity (HP:0100679)	1.17643902
93	Widely spaced teeth (HP:0000687)	1.16893340
94	Selective tooth agenesis (HP:0001592)	1.14153129
95	Type 1 muscle fiber predominance (HP:0003803)	1.13363152
96	Increased connective tissue (HP:0009025)	1.12324333
97	Atrophic scars (HP:0001075)	1.12147429
98	Sparse scalp hair (HP:0002209)	1.11453309
99	Wide cranial sutures (HP:0010537)	1.09211881
100	Bronchomalacia (HP:0002780)	1.09119915

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	4.42171513
2	MAPKAPK3	4.19757780
3	FER	3.87318937
4	ERN1	3.86249916
5	MAP3K6	3.47685829
6	EPHB2	3.12017307
7	TAOK1	2.98107686
8	MAP3K3	2.81632480
9	TRIB3	2.64256784
10	LATS1	2.53917166
11	MAP3K2	2.44954501
12	MAP3K11	2.03503015
13	RPS6KB2	2.02683142
14	TTN	1.88696451
15	PIK3CG	1.88640127
16	MAP2K6	1.87900059
17	EEF2K	1.67721879
18	LATS2	1.67225842
19	EPHB1	1.56203654
20	NME1	1.49727378
21	FGFR2	1.48214854
22	BCR	1.40191098
23	MAP3K1	1.29777372
24	KSR2	1.28699887
25	MST1R	1.23563323
26	RIPK1	1.22159740
27	MAP2K3	1.21813761
28	FGFR4	1.20397104
29	CDK6	1.19211348
30	BMX	1.14626656
31	PKN2	1.13881677
32	FGFR1	1.12243581
33	BLK	1.09924137
34	FGFR3	1.08819794
35	PBK	1.07338898
36	LRRK2	1.06950687
37	MAPKAPK2	1.04849514
38	PDGFRA	1.02194646
39	PTK6	1.00893610
40	MAP3K7	0.99730709
41	MAP3K9	0.93534277
42	MAP2K4	0.89282427
43	RPS6KA4	0.82931540
44	MAP2K1	0.81663613
45	STK38	0.78048091
46	PTK2	0.76010209
47	PIM2	0.75796396
48	SIK1	0.75257372
49	TESK1	0.72345627
50	STK38L	0.71131506
51	PAK3	0.70440002
52	DYRK1B	0.69533098
53	PRKD1	0.69324659
54	MET	0.68806375
55	PAK4	0.68573529
56	DDR2	0.67711454
57	CDK19	0.67658976
58	ERBB4	0.63757820
59	MAP3K5	0.58873945
60	NEK1	0.57158350
61	NTRK2	0.57148446
62	TGFBR1	0.56952130
63	TRPM7	0.55902307
64	PRKCI	0.55268176
65	TYRO3	0.54155965
66	PRKCH	0.52219080
67	RET	0.50741046
68	ALK	0.49478932
69	MAP3K10	0.49117661
70	ERBB3	0.48420372
71	ERBB2	0.47502391
72	PAK6	0.47447577
73	MST4	0.45889972
74	JAK1	0.45216209
75	MAPK12	0.43944309
76	PAK2	0.43246262
77	GSK3A	0.42155461
78	RPS6KA1	0.42143095
79	CSNK1E	0.41876641
80	OBSCN	0.40156227
81	TYK2	0.39374845
82	MAP2K2	0.38662984
83	JAK2	0.37739089
84	ILK	0.37533163
85	LIMK1	0.37299113
86	EPHA3	0.36364309
87	PHKG2	0.32374064
88	PHKG1	0.32374064
89	MAP3K8	0.28348959
90	GRK6	0.28013803
91	FYN	0.27842595
92	SRC	0.24665545
93	CSNK1A1	0.24537198
94	ROCK2	0.24436504
95	CSNK1D	0.22682953
96	PRKACG	0.22506670
97	CSNK1A1L	0.21980372
98	HCK	0.21455093
99	PRKACA	0.21158895
100	MARK3	0.21087177

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.84076045
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.81183784
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.09163056
4	Fatty acid elongation_Homo sapiens_hsa00062	2.69875763
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.54066979
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.18671035
7	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.85514890
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.82180909
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.77626880
10	VEGF signaling pathway_Homo sapiens_hsa04370	1.75164648
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.72260179
12	Melanogenesis_Homo sapiens_hsa04916	1.59764069
13	Axon guidance_Homo sapiens_hsa04360	1.53083097
14	Histidine metabolism_Homo sapiens_hsa00340	1.39329383
15	Bladder cancer_Homo sapiens_hsa05219	1.39235606
16	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36985310
17	Glioma_Homo sapiens_hsa05214	1.35228655
18	Thyroid cancer_Homo sapiens_hsa05216	1.33880932
19	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.30576143
20	Proteoglycans in cancer_Homo sapiens_hsa05205	1.28859798
21	Caffeine metabolism_Homo sapiens_hsa00232	1.27117043
22	GnRH signaling pathway_Homo sapiens_hsa04912	1.26141963
23	Hippo signaling pathway_Homo sapiens_hsa04390	1.25706229
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.19740651
25	Tight junction_Homo sapiens_hsa04530	1.13569311
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.10804962
27	Pancreatic secretion_Homo sapiens_hsa04972	1.09925193
28	Acute myeloid leukemia_Homo sapiens_hsa05221	1.09865663
29	Mineral absorption_Homo sapiens_hsa04978	1.09361466
30	Long-term potentiation_Homo sapiens_hsa04720	1.08771502
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07618239
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.04465158
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.00186063
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.99233135
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.92547208
36	Adherens junction_Homo sapiens_hsa04520	0.91840965
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.91162120
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.90150732
39	Pertussis_Homo sapiens_hsa05133	0.88590872
40	ECM-receptor interaction_Homo sapiens_hsa04512	0.88371451
41	Non-small cell lung cancer_Homo sapiens_hsa05223	0.88331422
42	Long-term depression_Homo sapiens_hsa04730	0.86641385
43	Endometrial cancer_Homo sapiens_hsa05213	0.86511390
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.84823456
45	Ras signaling pathway_Homo sapiens_hsa04014	0.82178883
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.82050187
47	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.80516823
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78932167
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.76902393
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.76637782
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.76597359
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76039407
53	Amoebiasis_Homo sapiens_hsa05146	0.71784142
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.71625957
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.69314370
56	Renin secretion_Homo sapiens_hsa04924	0.67929005
57	Gastric acid secretion_Homo sapiens_hsa04971	0.67880415
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65749814
59	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.65639687
60	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61984199
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.61307163
62	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.60061378
63	Insulin resistance_Homo sapiens_hsa04931	0.58922535
64	Hepatitis C_Homo sapiens_hsa05160	0.58044420
65	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.57287817
66	Gap junction_Homo sapiens_hsa04540	0.56989406
67	Phototransduction_Homo sapiens_hsa04744	0.56605412
68	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.55765161
69	Rap1 signaling pathway_Homo sapiens_hsa04015	0.54650136
70	Salmonella infection_Homo sapiens_hsa05132	0.53487339
71	Butanoate metabolism_Homo sapiens_hsa00650	0.51606869
72	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51587024
73	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.51284462
74	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50342698
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.49716310
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49181024
77	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.48756284
78	Fatty acid degradation_Homo sapiens_hsa00071	0.48307273
79	Platelet activation_Homo sapiens_hsa04611	0.47678897
80	Focal adhesion_Homo sapiens_hsa04510	0.47582156
81	Salivary secretion_Homo sapiens_hsa04970	0.46616605
82	ErbB signaling pathway_Homo sapiens_hsa04012	0.46328697
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45304922
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44857609
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44648476
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43352295
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.43113237
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42838603
89	Prion diseases_Homo sapiens_hsa05020	0.42230188
90	p53 signaling pathway_Homo sapiens_hsa04115	0.40479518
91	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.40209732
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.38264746
93	Tuberculosis_Homo sapiens_hsa05152	0.37933953
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37818787
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.36651941
96	Olfactory transduction_Homo sapiens_hsa04740	0.36479583
97	Toxoplasmosis_Homo sapiens_hsa05145	0.33991671
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.33777537
99	Insulin signaling pathway_Homo sapiens_hsa04910	0.33454104
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.32008727

KRTAP8-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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