ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	citrulline biosynthetic process (GO:0019240)	8.97339256
2	adhesion of symbiont to host (GO:0044406)	8.70154066
3	peptide cross-linking (GO:0018149)	8.57968889
4	hair follicle morphogenesis (GO:0031069)	8.07599613
5	intermediate filament cytoskeleton organization (GO:0045104)	6.74110431
6	intermediate filament-based process (GO:0045103)	6.52691039
7	establishment of skin barrier (GO:0061436)	6.30686146
8	cell wall macromolecule catabolic process (GO:0016998)	6.19765137
9	cell wall macromolecule metabolic process (GO:0044036)	6.19765137
10	epidermis development (GO:0008544)	6.10665934
11	keratinocyte differentiation (GO:0030216)	6.00338602
12	citrulline metabolic process (GO:0000052)	5.93807688
13	regulation of water loss via skin (GO:0033561)	5.56585879
14	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.45988866
15	molting cycle process (GO:0022404)	5.25432898
16	hair cycle process (GO:0022405)	5.25432898
17	skin morphogenesis (GO:0043589)	5.21996087
18	hemidesmosome assembly (GO:0031581)	5.05453719
19	peptidyl-arginine modification (GO:0018195)	4.96054002
20	epidermal cell differentiation (GO:0009913)	4.67686712
21	hair cycle (GO:0042633)	34.3548301
22	molting cycle (GO:0042303)	34.3548301
23	tooth mineralization (GO:0034505)	3.86288259
24	keratinocyte development (GO:0003334)	3.82947333
25	multicellular organismal water homeostasis (GO:0050891)	3.74009852
26	negative regulation of keratinocyte proliferation (GO:0010839)	3.39008039
27	negative regulation of establishment of protein localization to plasma membrane (GO:0090005)	3.28265505
28	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.21433635
29	hair follicle development (GO:0001942)	3.15956024
30	positive regulation of hair cycle (GO:0042635)	3.10981288
31	positive regulation of hair follicle development (GO:0051798)	3.10981288
32	regulation of keratinocyte differentiation (GO:0045616)	3.09575951
33	water homeostasis (GO:0030104)	3.06518143
34	ectoderm development (GO:0007398)	2.97884497
35	regulation of hair follicle development (GO:0051797)	2.94629365
36	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.93734149
37	fatty acid elongation (GO:0030497)	2.89749284
38	epithelium development (GO:0060429)	2.89378762
39	gap junction assembly (GO:0016264)	2.81075874
40	atrioventricular valve morphogenesis (GO:0003181)	2.77968440
41	bone trabecula formation (GO:0060346)	2.75636184
42	negative regulation of protein localization to plasma membrane (GO:1903077)	2.72075284
43	positive regulation of epidermis development (GO:0045684)	2.69643301
44	regulation of hair cycle (GO:0042634)	2.67114633
45	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.64988757
46	positive regulation of meiotic cell cycle (GO:0051446)	2.61162853
47	ventricular cardiac muscle cell action potential (GO:0086005)	2.50560867
48	negative regulation of cell fate specification (GO:0009996)	2.44535002
49	regulation of epidermal cell differentiation (GO:0045604)	2.43312373
50	regulation of epidermis development (GO:0045682)	2.38823461
51	lymph vessel development (GO:0001945)	2.32908677
52	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.32552021
53	skin development (GO:0043588)	2.26174822
54	regulation of mesenchymal cell apoptotic process (GO:2001053)	2.23710093
55	positive regulation of epidermal cell differentiation (GO:0045606)	2.23605055
56	phosphatidylserine metabolic process (GO:0006658)	2.23144909
57	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.22095050
58	regulation of cardioblast differentiation (GO:0051890)	2.15956368
59	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.14132716
60	epithelial cell-cell adhesion (GO:0090136)	2.10312318
61	wound healing, spreading of epidermal cells (GO:0035313)	2.10255750
62	regulation of heart rate by cardiac conduction (GO:0086091)	2.09813368
63	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.09665977
64	positive regulation of monocyte chemotaxis (GO:0090026)	2.09027225
65	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	2.06126861
66	myotube differentiation (GO:0014902)	2.04731449
67	aging (GO:0007568)	2.01542441
68	cranial suture morphogenesis (GO:0060363)	2.00957584
69	intermediate filament organization (GO:0045109)	12.1822154
70	keratinization (GO:0031424)	12.0187096
71	desmosome organization (GO:0002934)	10.4729867
72	adhesion of symbiont to host cell (GO:0044650)	10.3072494
73	virion attachment to host cell (GO:0019062)	10.3072494
74	cell communication involved in cardiac conduction (GO:0086065)	1.99161443
75	outflow tract septum morphogenesis (GO:0003148)	1.97506262
76	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.97481517
77	regulation of ruffle assembly (GO:1900027)	1.94564809
78	regulation of keratinocyte proliferation (GO:0010837)	1.90577159
79	phosphatidylcholine acyl-chain remodeling (GO:0036151)	1.88689995
80	negative regulation of epidermis development (GO:0045683)	1.88181901
81	cell-substrate junction assembly (GO:0007044)	1.85328635
82	coronary vasculature morphogenesis (GO:0060977)	1.82829967
83	ephrin receptor signaling pathway (GO:0048013)	1.82822714
84	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.82158934
85	non-canonical Wnt signaling pathway (GO:0035567)	1.81220149
86	regulation of secondary heart field cardioblast proliferation (GO:0003266)	1.77023854
87	regulation of cardioblast proliferation (GO:0003264)	1.77023854
88	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	1.74631582
89	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	1.74631582
90	very long-chain fatty acid metabolic process (GO:0000038)	1.73027271
91	negative regulation of cell fate commitment (GO:0010454)	1.69701458
92	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	1.68518962
93	primary alcohol catabolic process (GO:0034310)	1.67024591
94	cardiac conduction (GO:0061337)	1.64440649
95	alditol phosphate metabolic process (GO:0052646)	1.64357231
96	outer ear morphogenesis (GO:0042473)	1.64074861
97	establishment of tissue polarity (GO:0007164)	1.62067131
98	establishment of planar polarity (GO:0001736)	1.62067131
99	keratinocyte proliferation (GO:0043616)	1.59310694
100	cardiac muscle cell action potential involved in contraction (GO:0086002)	1.58985657

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	7.27565680
2	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.72060196
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.54585022
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.77502139
5	CTCF_20526341_ChIP-Seq_ESCs_Human	2.27755890
6	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	2.09724842
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	12.7570904
8	* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.98357301
9	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.91493357
10	E2F1_20622854_ChIP-Seq_HELA_Human	1.81194901
11	TAF2_19829295_ChIP-Seq_ESCs_Human	1.77080157
12	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.74841214
13	EGR1_19032775_ChIP-ChIP_M12_Human	1.74527245
14	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.73287440
15	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.70738208
16	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.67509029
17	NANOG_20526341_ChIP-Seq_ESCs_Human	1.66266052
18	CTCF_27219007_Chip-Seq_Bcells_Human	1.59237709
19	ERG_20517297_ChIP-Seq_VCAP_Human	1.58375290
20	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.56267807
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54104437
22	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.52746421
23	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.52746421
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.51494263
25	P53_21459846_ChIP-Seq_SAOS-2_Human	1.50079080
26	LXR_22292898_ChIP-Seq_THP-1_Human	1.49686883
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.49300118
28	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.49245088
29	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	1.47991195
30	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.46575764
31	BCL6_27268052_Chip-Seq_Bcells_Human	1.42744214
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40490066
33	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.39317522
34	ATF3_27146783_Chip-Seq_COLON_Human	1.38449867
35	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.36499713
36	BCOR_27268052_Chip-Seq_Bcells_Human	1.35993427
37	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35586763
38	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.33679836
39	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.28468431
40	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.28307190
41	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.23131418
42	PHF8_20622854_ChIP-Seq_HELA_Human	1.21934744
43	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.19996990
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.19746415
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19544892
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.16556460
47	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15941396
48	P68_20966046_ChIP-Seq_HELA_Human	1.15242151
49	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14890251
50	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.13224584
51	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.12673884
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.12428197
53	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.11246370
54	TP63_23658742_ChIP-Seq_EP156T_Human	1.10025600
55	SMC4_20622854_ChIP-Seq_HELA_Human	1.09781713
56	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.09439672
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.09283671
58	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.08851304
59	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.08740492
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08060316
61	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.07540450
62	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06645502
63	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.06174021
64	GATA4_25053715_ChIP-Seq_YYC3_Human	1.04722233
65	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.04088310
66	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01870823
67	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.01299460
68	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.00752714
69	KLF5_25053715_ChIP-Seq_YYC3_Human	0.99984816
70	SPI1_20517297_ChIP-Seq_HL60_Human	0.97700602
71	SOX2_21211035_ChIP-Seq_LN229_Human	0.96051244
72	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.95364388
73	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.92874092
74	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92745443
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92159445
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92019435
77	ZNF263_19887448_ChIP-Seq_K562_Human	0.91127989
78	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.89994714
79	TP53_18474530_ChIP-ChIP_U2OS_Human	0.89890531
80	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89713546
81	RXR_22108803_ChIP-Seq_LS180_Human	0.89017549
82	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.88308198
83	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.88152663
84	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.87682400
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.87485228
86	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.85607869
87	* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.85517694
88	SOX2_20726797_ChIP-Seq_SW620_Human	0.84977214
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82669448
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.81921224
91	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.80644415
92	AR_21572438_ChIP-Seq_LNCaP_Human	0.79950546
93	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.79025142
94	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.78313951
95	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.76476371
96	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.75599371
97	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.75473934
98	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.74117455
99	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.73604093
100	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.73308308

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.75092696
2	MP0002098_abnormal_vibrissa_morphology	6.92591043
3	MP0000647_abnormal_sebaceous_gland	6.30513049
4	MP0002796_impaired_skin_barrier	6.12059297
5	MP0005275_abnormal_skin_tensile	5.31453254
6	MP0010234_abnormal_vibrissa_follicle	4.99579038
7	MP0000383_abnormal_hair_follicle	4.51823814
8	MP0000377_abnormal_hair_follicle	4.02421122
9	MP0010678_abnormal_skin_adnexa	4.00239413
10	MP0005501_abnormal_skin_physiology	3.83519259
11	MP0003705_abnormal_hypodermis_morpholog	3.79567591
12	MP0000427_abnormal_hair_cycle	3.49303782
13	MP0002254_reproductive_system_inflammat	2.95496079
14	MP0001216_abnormal_epidermal_layer	2.71978568
15	MP0004381_abnormal_hair_follicle	2.56278528
16	MP0004947_skin_inflammation	2.37332921
17	MP0010771_integument_phenotype	2.34954082
18	MP0000367_abnormal_coat/_hair	2.31496491
19	MP0002060_abnormal_skin_morphology	2.20765733
20	MP0003453_abnormal_keratinocyte_physiol	2.18649723
21	MP0001243_abnormal_dermal_layer	2.15541481
22	MP0002234_abnormal_pharynx_morphology	2.03092250
23	MP0000467_abnormal_esophagus_morphology	1.82233307
24	MP0009931_abnormal_skin_appearance	1.51419766
25	MP0000762_abnormal_tongue_morphology	1.50327508
26	MP0009053_abnormal_anal_canal	1.46767199
27	MP0003566_abnormal_cell_adhesion	1.46023804
28	MP0005409_darkened_coat_color	1.34536633
29	MP0003941_abnormal_skin_development	1.21953234
30	MP0001191_abnormal_skin_condition	1.02168661
31	MP0004885_abnormal_endolymph	0.93362255
32	MP0004185_abnormal_adipocyte_glucose	0.90848109
33	MP0001851_eye_inflammation	0.85538300
34	MP0004264_abnormal_extraembryonic_tissu	0.84540779
35	MP0002095_abnormal_skin_pigmentation	0.84214853
36	MP0008438_abnormal_cutaneous_collagen	0.70870326
37	MP0001849_ear_inflammation	0.69272762
38	MP0001346_abnormal_lacrimal_gland	0.66442169
39	MP0001340_abnormal_eyelid_morphology	0.65286931
40	MP0003315_abnormal_perineum_morphology	0.64512158
41	MP0001661_extended_life_span	0.62107247
42	MP0002877_abnormal_melanocyte_morpholog	0.61964608
43	MP0010030_abnormal_orbit_morphology	0.59532828
44	MP0005451_abnormal_body_composition	0.57618045
45	MP0003191_abnormal_cellular_cholesterol	0.57046645
46	MP0000566_synostosis	0.56993688
47	MP0000627_abnormal_mammary_gland	0.55092213
48	MP0002282_abnormal_trachea_morphology	0.52463475
49	MP0005023_abnormal_wound_healing	0.50107781
50	MP0003755_abnormal_palate_morphology	0.49739437
51	MP0001784_abnormal_fluid_regulation	0.48178702
52	MP0002970_abnormal_white_adipose	0.45079878
53	MP0002249_abnormal_larynx_morphology	0.42208514
54	MP0000678_abnormal_parathyroid_gland	0.39932749
55	MP0002111_abnormal_tail_morphology	0.38883987
56	MP0005075_abnormal_melanosome_morpholog	0.35126702
57	MP0010352_gastrointestinal_tract_polyps	0.32695619
58	MP0004272_abnormal_basement_membrane	0.32542903
59	MP0002177_abnormal_outer_ear	0.31470614
60	MP0003385_abnormal_body_wall	0.30550263
61	MP0009840_abnormal_foam_cell	0.29753294
62	MP0000537_abnormal_urethra_morphology	0.28209557
63	MP0000465_gastrointestinal_hemorrhage	0.26962186
64	MP0003763_abnormal_thymus_physiology	0.25889603
65	MP0003950_abnormal_plasma_membrane	0.25730175
66	MP0002697_abnormal_eye_size	0.24960179
67	MP0005248_abnormal_Harderian_gland	0.23630016
68	MP0003329_amyloid_beta_deposits	0.23404715
69	MP0003300_gastrointestinal_ulcer	0.22180329
70	MP0006054_spinal_hemorrhage	0.19789571
71	MP0004019_abnormal_vitamin_homeostasis	0.19413715
72	MP0001879_abnormal_lymphatic_vessel	0.19162263
73	MP0004742_abnormal_vestibular_system	0.18493152
74	MP0000432_abnormal_head_morphology	0.17855792
75	MP0005666_abnormal_adipose_tissue	0.16334569
76	MP0005375_adipose_tissue_phenotype	0.15317534
77	MP0003448_altered_tumor_morphology	0.15296332
78	MP0003935_abnormal_craniofacial_develop	0.14832948
79	MP0003011_delayed_dark_adaptation	0.14830143
80	MP0004858_abnormal_nervous_system	0.14022836
81	MP0005367_renal/urinary_system_phenotyp	0.13669456
82	MP0000516_abnormal_urinary_system	0.13669456
83	MP0005076_abnormal_cell_differentiation	0.13239189
84	MP0003638_abnormal_response/metabolism_	0.11626024
85	MP0000604_amyloidosis	0.11498544
86	MP0002233_abnormal_nose_morphology	0.10716038
87	MP0005193_abnormal_anterior_eye	0.10452458
88	MP0000733_abnormal_muscle_development	0.10265481
89	MP0001188_hyperpigmentation	0.10062187
90	MP0002006_tumorigenesis	0.10001693
91	MP0003075_altered_response_to	0.09816719
92	MP0002166_altered_tumor_susceptibility	0.09393802
93	MP0010368_abnormal_lymphatic_system	0.08881960
94	MP0003045_fibrosis	0.08511505
95	MP0000462_abnormal_digestive_system	0.08342536
96	MP0000751_myopathy	0.08233948
97	MP0009384_cardiac_valve_regurgitation	0.08013057
98	MP0008569_lethality_at_weaning	0.07770850
99	MP0001958_emphysema	0.07451687
100	MP0009379_abnormal_foot_pigmentation	0.06742541

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Brittle hair (HP:0002299)	9.58981464
2	Pili torti (HP:0003777)	9.28183822
3	Nail dystrophy (HP:0008404)	7.06114620
4	Abnormality of nail color (HP:0100643)	6.79343651
5	Abnormal hair laboratory examination (HP:0003328)	5.86073665
6	Fragile nails (HP:0001808)	5.63175061
7	Increased IgE level (HP:0003212)	5.30264582
8	Palmoplantar hyperkeratosis (HP:0000972)	5.20426937
9	Onycholysis (HP:0001806)	5.16945363
10	Alopecia of scalp (HP:0002293)	5.11087806
11	Fine hair (HP:0002213)	4.97531099
12	Palmar hyperkeratosis (HP:0010765)	4.90153045
13	Thick nail (HP:0001805)	4.84590778
14	Plantar hyperkeratosis (HP:0007556)	4.71597451
15	Follicular hyperkeratosis (HP:0007502)	4.59175543
16	Right ventricular cardiomyopathy (HP:0011663)	4.44207812
17	Erythema (HP:0010783)	3.86566483
18	Sparse eyelashes (HP:0000653)	3.67389558
19	Oral leukoplakia (HP:0002745)	3.67250797
20	Milia (HP:0001056)	3.30934414
21	Erythroderma (HP:0001019)	3.20321552
22	Amelogenesis imperfecta (HP:0000705)	3.08830940
23	Abnormality of the frontal sinuses (HP:0002687)	3.05316419
24	Parakeratosis (HP:0001036)	2.92771799
25	Curly hair (HP:0002212)	2.76786513
26	Ridged nail (HP:0001807)	2.73445448
27	Congenital, generalized hypertrichosis (HP:0004540)	2.67290053
28	Intention tremor (HP:0002080)	2.63684997
29	Abnormal blistering of the skin (HP:0008066)	2.62567379
30	Congenital ichthyosiform erythroderma (HP:0007431)	2.55024954
31	Natal tooth (HP:0000695)	2.50304568
32	Neck muscle weakness (HP:0000467)	2.44898994
33	Advanced eruption of teeth (HP:0006288)	2.44749612
34	Aplasia cutis congenita (HP:0001057)	2.41463417
35	Torticollis (HP:0000473)	2.31091753
36	Dry hair (HP:0011359)	2.30927896
37	Hypohidrosis (HP:0000966)	2.17745018
38	Palmoplantar keratoderma (HP:0000982)	2.14318962
39	Corneal erosion (HP:0200020)	2.14242717
40	Ventricular tachycardia (HP:0004756)	2.13045072
41	Conjunctival hamartoma (HP:0100780)	2.05520779
42	Pruritus (HP:0000989)	2.00595870
43	Hypotrichosis (HP:0001006)	14.2429446
44	Woolly hair (HP:0002224)	11.2039594
45	Slow-growing hair (HP:0002217)	10.4824754
46	Abnormality of hair growth rate (HP:0011363)	10.4824754
47	Craniofacial dystonia (HP:0012179)	1.94588062
48	Difficulty walking (HP:0002355)	1.89696632
49	Ventricular fibrillation (HP:0001663)	1.87784135
50	Abnormality of the pupil (HP:0000615)	1.78315313
51	Focal dystonia (HP:0004373)	1.77733677
52	Taurodontia (HP:0000679)	1.73215333
53	Abnormality of permanent molar morphology (HP:0011071)	1.73215333
54	Abnormality of the dental root (HP:0006486)	1.73215333
55	Fatigable weakness (HP:0003473)	1.71687416
56	Abnormality of the neuromuscular junction (HP:0003398)	1.71687416
57	Abnormality of molar (HP:0011077)	1.70678299
58	Abnormality of molar morphology (HP:0011070)	1.70678299
59	Abnormality of the parietal bone (HP:0002696)	1.69262509
60	Abnormality of dental color (HP:0011073)	1.69025461
61	Concave nail (HP:0001598)	1.68803458
62	Absent eyelashes (HP:0000561)	1.66553503
63	Recurrent corneal erosions (HP:0000495)	1.63296783
64	Widely patent fontanelles and sutures (HP:0004492)	1.62678418
65	Blepharitis (HP:0000498)	1.61189765
66	Unilateral renal agenesis (HP:0000122)	1.60959779
67	Hyporeflexia of lower limbs (HP:0002600)	1.57788068
68	Hypergammaglobulinemia (HP:0010702)	1.56371384
69	Abnormality of the aortic arch (HP:0012303)	1.53213505
70	Gangrene (HP:0100758)	1.52255486
71	Sudden death (HP:0001699)	1.52208088
72	Abnormality of the dental pulp (HP:0006479)	1.51218413
73	Abnormality of placental membranes (HP:0011409)	1.48805810
74	Amniotic constriction ring (HP:0009775)	1.48805810
75	Acanthosis nigricans (HP:0000956)	1.48652138
76	Anonychia (HP:0001798)	1.48579331
77	Carious teeth (HP:0000670)	1.47306113
78	Lip pit (HP:0100267)	1.44893770
79	Ectropion (HP:0000656)	1.42661537
80	Laryngomalacia (HP:0001601)	1.40155508
81	Keratoconjunctivitis sicca (HP:0001097)	1.37633861
82	Heterogeneous (HP:0001425)	1.34507800
83	Abnormality of the fingernails (HP:0001231)	1.33518140
84	Autoamputation (HP:0001218)	1.32465106
85	Hamartoma of the eye (HP:0010568)	1.31515853
86	Achilles tendon contracture (HP:0001771)	1.30875785
87	Craniofacial hyperostosis (HP:0004493)	1.30303648
88	Distal lower limb muscle weakness (HP:0009053)	1.30128306
89	Neonatal onset (HP:0003623)	1.27342981
90	Round ear (HP:0100830)	1.23503532
91	Abnormality of the Achilles tendon (HP:0005109)	1.22861356
92	Atrophic scars (HP:0001075)	1.22559203
93	Hyperhidrosis (HP:0000975)	1.22496274
94	Corneal dystrophy (HP:0001131)	1.21177400
95	Sparse scalp hair (HP:0002209)	1.20901060
96	Keratoconjunctivitis (HP:0001096)	1.20873713
97	Type 1 muscle fiber predominance (HP:0003803)	1.20216099
98	Selective tooth agenesis (HP:0001592)	1.18095986
99	Abnormality of the gastric mucosa (HP:0004295)	1.17871002
100	Increased connective tissue (HP:0009025)	1.17207702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FER	4.40185564
2	EPHA2	4.11494081
3	MAPKAPK3	3.95271814
4	ERN1	3.87301404
5	MAP3K6	3.72928163
6	EPHB2	3.13843074
7	TAOK1	3.10381135
8	MAP3K3	2.75476294
9	TRIB3	2.72428172
10	LATS1	2.36478402
11	MAP3K2	2.35570164
12	MAP3K11	2.09904810
13	RPS6KB2	1.92002652
14	PIK3CG	1.90593775
15	TTN	1.89207242
16	EEF2K	1.86673168
17	EPHB1	1.80200441
18	MAP2K6	1.58831399
19	LATS2	1.54202592
20	BCR	1.46214034
21	FGFR4	1.43624049
22	FGFR1	1.34356350
23	MAP3K1	1.30970182
24	RIPK1	1.28235160
25	NME1	1.25104973
26	MST1R	1.24891231
27	FGFR2	1.21875147
28	BMX	1.20119501
29	PKN2	1.17935720
30	MAP2K3	1.16754238
31	KSR2	1.14914720
32	CDK6	1.14740488
33	FGFR3	1.13763852
34	BLK	1.12077806
35	MAPKAPK2	1.09676643
36	PDGFRA	1.08373863
37	PTK6	1.01721345
38	MAP3K7	1.00718568
39	MAP3K9	0.99805322
40	LRRK2	0.97775256
41	SIK1	0.93672626
42	PBK	0.85614650
43	PTK2	0.85319438
44	RPS6KA4	0.84946373
45	MAP2K4	0.82320299
46	OBSCN	0.81284507
47	MAP2K1	0.73168402
48	MET	0.72174523
49	STK38	0.70296706
50	MAP3K10	0.69702183
51	PRKD1	0.68903205
52	PAK4	0.68800151
53	DYRK1B	0.68193426
54	PIM2	0.67137102
55	PAK3	0.66395984
56	TESK1	0.65972073
57	DDR2	0.63739695
58	CDK19	0.61419938
59	TYK2	0.60495724
60	STK38L	0.59271811
61	EPHA3	0.58068552
62	NTRK2	0.57247344
63	JAK1	0.57150399
64	TRPM7	0.56552356
65	PRKCI	0.54749022
66	PRKCH	0.53649800
67	TYRO3	0.53446219
68	PAK2	0.52147446
69	RET	0.51419735
70	MAP3K5	0.51049937
71	ERBB4	0.50772959
72	ERBB2	0.49382231
73	PAK6	0.48890382
74	TGFBR1	0.46293824
75	RPS6KA1	0.45735015
76	MAPK12	0.45115303
77	ALK	0.42396198
78	NEK1	0.39803222
79	GSK3A	0.39789340
80	CLK1	0.38628947
81	CSNK1E	0.37200555
82	MST4	0.36824047
83	JAK2	0.35022971
84	MAP2K2	0.32994980
85	FYN	0.32588466
86	TGFBR2	0.31712098
87	MAP3K8	0.30469374
88	GRK6	0.30357323
89	PHKG1	0.26356323
90	PHKG2	0.26356323
91	LIMK1	0.26294946
92	SRC	0.25011312
93	STK11	0.24248370
94	HCK	0.23938857
95	CSNK1A1	0.23845321
96	ILK	0.23409819
97	ICK	0.22658782
98	ERBB3	0.22100800
99	PRKACG	0.21746745
100	MAPK8	0.20890350

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	4.71270529
2	Linoleic acid metabolism_Homo sapiens_hsa00591	4.66301906
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.08059051
4	Fatty acid elongation_Homo sapiens_hsa00062	3.00882253
5	Ether lipid metabolism_Homo sapiens_hsa00565	2.46565307
6	Basal cell carcinoma_Homo sapiens_hsa05217	2.19055186
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.94530008
8	Phenylalanine metabolism_Homo sapiens_hsa00360	1.85591438
9	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.81894016
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.79738605
11	VEGF signaling pathway_Homo sapiens_hsa04370	1.68329660
12	Melanogenesis_Homo sapiens_hsa04916	1.55633693
13	Axon guidance_Homo sapiens_hsa04360	1.53874704
14	Caffeine metabolism_Homo sapiens_hsa00232	1.46951491
15	Histidine metabolism_Homo sapiens_hsa00340	1.35204429
16	Glioma_Homo sapiens_hsa05214	1.35028614
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.34435426
18	Bladder cancer_Homo sapiens_hsa05219	1.28743174
19	Proteoglycans in cancer_Homo sapiens_hsa05205	1.28164594
20	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.28002970
21	Thyroid cancer_Homo sapiens_hsa05216	1.27514596
22	Acute myeloid leukemia_Homo sapiens_hsa05221	1.26651728
23	GnRH signaling pathway_Homo sapiens_hsa04912	1.23286930
24	Hippo signaling pathway_Homo sapiens_hsa04390	1.22370485
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.17754327
26	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.16833526
27	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.14905631
28	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14325655
29	Tight junction_Homo sapiens_hsa04530	1.13556865
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.07354148
31	Mineral absorption_Homo sapiens_hsa04978	1.06572832
32	Pancreatic secretion_Homo sapiens_hsa04972	1.05947059
33	Adherens junction_Homo sapiens_hsa04520	1.04036607
34	ECM-receptor interaction_Homo sapiens_hsa04512	1.01492071
35	Long-term potentiation_Homo sapiens_hsa04720	0.98580298
36	Nitrogen metabolism_Homo sapiens_hsa00910	0.97783345
37	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.95975364
38	Tyrosine metabolism_Homo sapiens_hsa00350	0.91130807
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.90127232
40	Pertussis_Homo sapiens_hsa05133	0.88350206
41	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87937131
42	Endometrial cancer_Homo sapiens_hsa05213	0.85669188
43	Non-small cell lung cancer_Homo sapiens_hsa05223	0.85404585
44	Estrogen signaling pathway_Homo sapiens_hsa04915	0.83112956
45	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.81899463
46	Ras signaling pathway_Homo sapiens_hsa04014	0.81396664
47	Amoebiasis_Homo sapiens_hsa05146	0.80745843
48	Long-term depression_Homo sapiens_hsa04730	0.80694158
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78253592
50	Wnt signaling pathway_Homo sapiens_hsa04310	0.75331936
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.75061553
52	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.74982203
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.74210676
54	Gastric acid secretion_Homo sapiens_hsa04971	0.72053005
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.68827268
56	Phototransduction_Homo sapiens_hsa04744	0.67533395
57	Renin secretion_Homo sapiens_hsa04924	0.67043823
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63708141
59	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63596666
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63113358
61	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.62631723
62	Insulin resistance_Homo sapiens_hsa04931	0.62237579
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61081867
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.60460203
65	Hepatitis C_Homo sapiens_hsa05160	0.59196712
66	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.58438050
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.56503472
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56196518
69	Salivary secretion_Homo sapiens_hsa04970	0.52971626
70	Focal adhesion_Homo sapiens_hsa04510	0.52934083
71	Salmonella infection_Homo sapiens_hsa05132	0.52800497
72	Gap junction_Homo sapiens_hsa04540	0.52022814
73	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.50829131
74	Platelet activation_Homo sapiens_hsa04611	0.49867037
75	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.49328843
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.49132516
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.48977078
78	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.48580783
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.46088528
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45865027
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.44354134
82	Fatty acid degradation_Homo sapiens_hsa00071	0.44267141
83	Notch signaling pathway_Homo sapiens_hsa04330	0.43577668
84	Toxoplasmosis_Homo sapiens_hsa05145	0.43319403
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42767608
86	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42398375
87	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42019304
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41543954
89	Tuberculosis_Homo sapiens_hsa05152	0.41501401
90	Olfactory transduction_Homo sapiens_hsa04740	0.39310271
91	Butanoate metabolism_Homo sapiens_hsa00650	0.39258495
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.38486007
93	Prion diseases_Homo sapiens_hsa05020	0.37767773
94	Prolactin signaling pathway_Homo sapiens_hsa04917	0.37534158
95	Insulin signaling pathway_Homo sapiens_hsa04910	0.37442848
96	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.34980959
97	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.34572500
98	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33816684
99	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.32807976
100	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.31030615

KRTAP9-1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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