KRTAP9-3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adhesion of symbiont to host cell (GO:0044650)9.98123730
2virion attachment to host cell (GO:0019062)9.98123730
3citrulline biosynthetic process (GO:0019240)8.85272510
4peptide cross-linking (GO:0018149)8.54347812
5adhesion of symbiont to host (GO:0044406)8.42561989
6hair follicle morphogenesis (GO:0031069)8.26137520
7intermediate filament cytoskeleton organization (GO:0045104)6.77819119
8intermediate filament-based process (GO:0045103)6.56231745
9epidermis development (GO:0008544)6.20146189
10establishment of skin barrier (GO:0061436)6.11815036
11cell wall macromolecule catabolic process (GO:0016998)5.94131658
12cell wall macromolecule metabolic process (GO:0044036)5.94131658
13citrulline metabolic process (GO:0000052)5.86065189
14keratinocyte differentiation (GO:0030216)5.85554833
15linoleic acid metabolic process (GO:0043651)5.62077069
16regulation of water loss via skin (GO:0033561)5.40497680
17hair cycle process (GO:0022405)5.30178725
18molting cycle process (GO:0022404)5.30178725
19bundle of His cell to Purkinje myocyte communication (GO:0086069)5.16960982
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.11765059
21hemidesmosome assembly (GO:0031581)5.07169714
22fatty-acyl-CoA biosynthetic process (GO:0046949)4.89873283
23peptidyl-arginine modification (GO:0018195)4.88372823
24skin morphogenesis (GO:0043589)4.87157994
25epidermal cell differentiation (GO:0009913)4.55335594
26retinol metabolic process (GO:0042572)4.38258441
27fatty-acyl-CoA metabolic process (GO:0035337)4.06922719
28thioester biosynthetic process (GO:0035384)4.05357077
29acyl-CoA biosynthetic process (GO:0071616)4.05357077
30molting cycle (GO:0042303)34.8848504
31hair cycle (GO:0042633)34.8848504
32keratinocyte development (GO:0003334)3.84243638
33tooth mineralization (GO:0034505)3.75917809
34multicellular organismal water homeostasis (GO:0050891)3.62298223
35phosphatidylinositol acyl-chain remodeling (GO:0036149)3.38847887
36alpha-linolenic acid metabolic process (GO:0036109)3.38241415
37negative regulation of keratinocyte proliferation (GO:0010839)3.35238526
38regulation of keratinocyte differentiation (GO:0045616)3.23129949
39primary alcohol metabolic process (GO:0034308)3.20505535
40negative regulation of establishment of protein localization to plasma membrane (GO:0090005)3.18247661
41positive regulation of hair follicle development (GO:0051798)3.15558981
42positive regulation of hair cycle (GO:0042635)3.15558981
43hair follicle development (GO:0001942)3.11690710
44phosphatidylserine acyl-chain remodeling (GO:0036150)3.10928654
45long-chain fatty acid biosynthetic process (GO:0042759)3.10174502
46positive regulation of chemokine secretion (GO:0090197)3.04932516
47positive regulation of keratinocyte differentiation (GO:0045618)2.99324496
48water homeostasis (GO:0030104)2.96787291
49regulation of hair follicle development (GO:0051797)2.94744379
50epithelium development (GO:0060429)2.93258817
51triglyceride biosynthetic process (GO:0019432)2.88447269
52ectoderm development (GO:0007398)2.87960525
53defense response to fungus (GO:0050832)2.87361512
54phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.85328466
55bone trabecula formation (GO:0060346)2.84921160
56disruption of cells of other organism (GO:0044364)2.83388017
57killing of cells of other organism (GO:0031640)2.83388017
58regulation of chemokine secretion (GO:0090196)2.75467881
59gap junction assembly (GO:0016264)2.74758902
60acylglycerol biosynthetic process (GO:0046463)2.74223186
61neutral lipid biosynthetic process (GO:0046460)2.74223186
62positive regulation of epidermis development (GO:0045684)2.70058910
63regulation of sequestering of triglyceride (GO:0010889)2.67370756
64regulation of hair cycle (GO:0042634)2.67144136
65fatty acid elongation (GO:0030497)2.66735305
66positive regulation of meiotic cell cycle (GO:0051446)2.64822732
67negative regulation of protein localization to plasma membrane (GO:1903077)2.63261257
68atrioventricular valve morphogenesis (GO:0003181)2.61496828
69regulation of epidermal cell differentiation (GO:0045604)2.52663939
70lipoxygenase pathway (GO:0019372)2.45388576
71thioester metabolic process (GO:0035383)2.45021570
72acyl-CoA metabolic process (GO:0006637)2.45021570
73regulation of epidermis development (GO:0045682)2.44199447
74ventricular cardiac muscle cell action potential (GO:0086005)2.38176685
75phosphatidylserine metabolic process (GO:0006658)2.33656512
76epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.33644182
77negative regulation of cell fate specification (GO:0009996)2.30376336
78phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.26974552
79carnitine metabolic process (GO:0009437)2.26399953
80response to phenylpropanoid (GO:0080184)2.24746524
81positive regulation of epidermal cell differentiation (GO:0045606)2.22797082
82skin development (GO:0043588)2.19752176
83wound healing, spreading of epidermal cells (GO:0035313)2.18667592
84positive regulation of monocyte chemotaxis (GO:0090026)2.17211969
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.16559450
86negative regulation of execution phase of apoptosis (GO:1900118)2.16557036
87regulation of mesenchymal cell apoptotic process (GO:2001053)2.16326594
88regulation of defense response to virus by host (GO:0050691)2.13701852
89lymph vessel development (GO:0001945)2.10982611
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.08613955
91cranial suture morphogenesis (GO:0060363)2.05742215
92aging (GO:0007568)2.05284434
93regulation of cardioblast differentiation (GO:0051890)2.03099573
94regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.01895014
95epithelial cell-cell adhesion (GO:0090136)2.01208199
96phosphatidylcholine acyl-chain remodeling (GO:0036151)2.00631811
97intermediate filament organization (GO:0045109)12.2856499
98keratinization (GO:0031424)11.9780005
99desmosome organization (GO:0002934)10.2209538
100regulation of ruffle assembly (GO:1900027)1.99792721
101regulation of heart rate by cardiac conduction (GO:0086091)1.98770848
102cytoskeletal anchoring at plasma membrane (GO:0007016)1.97606542
103planar cell polarity pathway involved in neural tube closure (GO:0090179)1.93245468
104myotube differentiation (GO:0014902)1.92408034
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)1.90355121
106outflow tract septum morphogenesis (GO:0003148)1.90285475
107negative regulation of epidermis development (GO:0045683)1.90265170
108cell communication involved in cardiac conduction (GO:0086065)1.88740809
109regulation of keratinocyte proliferation (GO:0010837)1.87400376
110fatty acid biosynthetic process (GO:0006633)1.84862133
111one-carbon compound transport (GO:0019755)1.84542863
112cell-substrate junction assembly (GO:0007044)1.84102880
113response to fungus (GO:0009620)1.83302037
114ethanol metabolic process (GO:0006067)1.82649755
115ephrin receptor signaling pathway (GO:0048013)1.82532933
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.77739168
117phosphatidic acid biosynthetic process (GO:0006654)1.77197352
118phosphatidic acid metabolic process (GO:0046473)1.77197352
119non-canonical Wnt signaling pathway (GO:0035567)1.76392398
120primary alcohol catabolic process (GO:0034310)1.72882883
121alditol phosphate metabolic process (GO:0052646)1.72580221
122keratinocyte proliferation (GO:0043616)1.70620679
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.68609552
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.68609552
125unsaturated fatty acid biosynthetic process (GO:0006636)1.68348053
126very long-chain fatty acid metabolic process (GO:0000038)1.64815278
127coronary vasculature morphogenesis (GO:0060977)1.63708356
128epithelial cell differentiation involved in prostate gland development (GO:0060742)1.61726529
129establishment of tissue polarity (GO:0007164)1.61660851
130establishment of planar polarity (GO:0001736)1.61660851
131regulation of secondary heart field cardioblast proliferation (GO:0003266)1.60649093
132regulation of cardioblast proliferation (GO:0003264)1.60649093
133regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.58481942
134negative regulation of cell fate commitment (GO:0010454)1.58112040
135amino-acid betaine metabolic process (GO:0006577)1.58055042
136cardiac right ventricle morphogenesis (GO:0003215)1.56870507
137long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.56258416
138wound healing, spreading of cells (GO:0044319)1.55688682
139hair cell differentiation (GO:0035315)1.55031107
140lipid storage (GO:0019915)1.52373963
141regulation of phospholipase A2 activity (GO:0032429)1.50641798
142triglyceride metabolic process (GO:0006641)1.45206602
143phospholipid catabolic process (GO:0009395)1.44004253
144retinoid metabolic process (GO:0001523)1.42578950
145diterpenoid metabolic process (GO:0016101)1.40828393
146positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.39332137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.16075771
2CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.83071031
3P63_26484246_Chip-Seq_KERATINOCYTES_Human3.57872010
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67466547
5* CTCF_20526341_ChIP-Seq_ESCs_Human2.19553372
6BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.15127367
7NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse2.11154674
8TP63_17297297_ChIP-ChIP_HaCaT_Human12.9095941
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91147077
10E2F1_20622854_ChIP-Seq_HELA_Human1.85416656
11TAF2_19829295_ChIP-Seq_ESCs_Human1.82899685
12EGR1_19032775_ChIP-ChIP_M12_Human1.74395522
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.74186816
14P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.73545317
15NANOG_20526341_ChIP-Seq_ESCs_Human1.70736686
16SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70674244
17ERG_20517297_ChIP-Seq_VCAP_Human1.62765982
18P53_21459846_ChIP-Seq_SAOS-2_Human1.58262155
19* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.56461037
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54877932
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.53709644
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52204069
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52204069
24TP63_22573176_ChIP-Seq_HFKS_Human1.50447162
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.50104398
26RACK7_27058665_Chip-Seq_MCF-7_Human1.50017781
27BCL6_27268052_Chip-Seq_Bcells_Human1.49574802
28LXR_22292898_ChIP-Seq_THP-1_Human1.48357633
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.47256847
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46827015
31MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.46231362
32* CTCF_27219007_Chip-Seq_Bcells_Human1.45580842
33BCOR_27268052_Chip-Seq_Bcells_Human1.42695612
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.40121617
35ATF3_27146783_Chip-Seq_COLON_Human1.37472392
36UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36687391
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34887131
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33682727
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.28105358
40PHF8_20622854_ChIP-Seq_HELA_Human1.25582834
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.23224725
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23121680
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22366756
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.22366756
45* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21903710
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21610240
47P68_20966046_ChIP-Seq_HELA_Human1.21348184
48AHR_22903824_ChIP-Seq_MCF-7_Human1.20644443
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.18377322
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17400106
51CEBPB_22108803_ChIP-Seq_LS180_Human1.16637255
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15682856
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13308817
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.12857841
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12413581
56RAC3_21632823_ChIP-Seq_H3396_Human1.11504141
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11086295
58GATA3_24758297_ChIP-Seq_MCF-7_Human1.10209980
59TP63_23658742_ChIP-Seq_EP156T_Human1.10195825
60SMC4_20622854_ChIP-Seq_HELA_Human1.09236180
61ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08409211
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06842720
63UBF1/2_26484160_Chip-Seq_HMECs_Human1.06246429
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05527456
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04863904
66GATA4_25053715_ChIP-Seq_YYC3_Human1.04825015
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04606462
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04135765
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02380433
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.01785624
71SPI1_20517297_ChIP-Seq_HL60_Human1.01073233
72SOX2_21211035_ChIP-Seq_LN229_Human1.00999316
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97309589
74KLF5_25053715_ChIP-Seq_YYC3_Human0.97251983
75RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96943650
76TP53_18474530_ChIP-ChIP_U2OS_Human0.95741028
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95600593
78* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94650795
79FOXH1_21741376_ChIP-Seq_ESCs_Human0.93474257
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93205259
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.92567162
82HTT_18923047_ChIP-ChIP_STHdh_Human0.91549919
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90878748
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.90259615
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89340033
86RXR_22108803_ChIP-Seq_LS180_Human0.88347288
87RUNX1_27514584_Chip-Seq_MCF-7_Human0.87077960
88RING1B_27294783_Chip-Seq_ESCs_Mouse0.86518896
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84939235
90ZNF263_19887448_ChIP-Seq_K562_Human0.84785502
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84680138
92SOX2_20726797_ChIP-Seq_SW620_Human0.83531288
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83114742
94CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82399048
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82091962
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81592762
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81592762
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80851708
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.79879854
100EZH2_27294783_Chip-Seq_ESCs_Mouse0.78045267
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.76947423
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75681185
103AR_21572438_ChIP-Seq_LNCaP_Human0.75298010
104ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75139455
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.74718619
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.74248302
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.73936186
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.73245401
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73140839
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72863925
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72704344
112STAT1_20625510_ChIP-Seq_HELA_Human0.72147446
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.72004822
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.71815204
115HNFA_21074721_ChIP-Seq_CACO-2_Human0.70780564
116PHF8_20622853_ChIP-Seq_HELA_Human0.70667887
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.69769881
118ERA_21632823_ChIP-Seq_H3396_Human0.69248831
119P300_27268052_Chip-Seq_Bcells_Human0.68507654
120KAP1_27257070_Chip-Seq_ESCs_Mouse0.68235000
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.66875739
122MYC_19829295_ChIP-Seq_ESCs_Human0.66339106
123TP53_16413492_ChIP-PET_HCT116_Human0.66316693
124FOXH1_21741376_ChIP-Seq_EPCs_Human0.64195880
125KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64164501
126OCT4_20526341_ChIP-Seq_ESCs_Human0.60899418
127CBP_20019798_ChIP-Seq_JUKART_Human0.60712391
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.60712391
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.60358693
130RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.59511513
131AR_20517297_ChIP-Seq_VCAP_Human0.58852868
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.58514860
133RBPJ_21746931_ChIP-Seq_IB4_Human0.58441354
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.57925130
135NCOR_22424771_ChIP-Seq_293T_Human0.57460986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.65418189
2MP0002098_abnormal_vibrissa_morphology7.09457597
3MP0000647_abnormal_sebaceous_gland6.36521796
4MP0002796_impaired_skin_barrier6.00350325
5MP0005275_abnormal_skin_tensile5.18572750
6MP0010234_abnormal_vibrissa_follicle5.06630983
7MP0000383_abnormal_hair_follicle4.53254143
8MP0000377_abnormal_hair_follicle4.04972370
9MP0010678_abnormal_skin_adnexa4.00940029
10MP0005501_abnormal_skin_physiology3.76388733
11MP0003705_abnormal_hypodermis_morpholog3.74432778
12MP0000427_abnormal_hair_cycle3.45083744
13MP0002254_reproductive_system_inflammat3.01085832
14MP0004381_abnormal_hair_follicle2.71331732
15MP0001216_abnormal_epidermal_layer2.70881480
16MP0005377_hearing/vestibular/ear_phenot2.38221894
17MP0003878_abnormal_ear_physiology2.38221894
18MP0000367_abnormal_coat/_hair2.36156628
19MP0010771_integument_phenotype2.34313008
20MP0004947_skin_inflammation2.32416246
21MP0002060_abnormal_skin_morphology2.22283932
22MP0003453_abnormal_keratinocyte_physiol2.22183334
23MP0001243_abnormal_dermal_layer2.13325865
24MP0002234_abnormal_pharynx_morphology2.03004799
25MP0000467_abnormal_esophagus_morphology1.82694147
26MP0009931_abnormal_skin_appearance1.52186115
27MP0000762_abnormal_tongue_morphology1.51118242
28MP0009053_abnormal_anal_canal1.50022637
29MP0003566_abnormal_cell_adhesion1.47645530
30MP0005409_darkened_coat_color1.36765692
31MP0003941_abnormal_skin_development1.24941136
32MP0001188_hyperpigmentation1.03106895
33MP0001191_abnormal_skin_condition1.00679261
34MP0006035_abnormal_mitochondrial_morpho0.95313034
35MP0005647_abnormal_sex_gland0.94040700
36MP0004885_abnormal_endolymph0.92772586
37MP0004185_abnormal_adipocyte_glucose0.90228992
38MP0004264_abnormal_extraembryonic_tissu0.85130835
39MP0001851_eye_inflammation0.84941481
40MP0002095_abnormal_skin_pigmentation0.82344860
41MP0008438_abnormal_cutaneous_collagen0.82218919
42MP0005174_abnormal_tail_pigmentation0.78834910
43MP0000015_abnormal_ear_pigmentation0.75839325
44MP0003315_abnormal_perineum_morphology0.68113206
45MP0001849_ear_inflammation0.65581902
46MP0001340_abnormal_eyelid_morphology0.63829215
47MP0001346_abnormal_lacrimal_gland0.62364507
48MP0010030_abnormal_orbit_morphology0.61770183
49MP0002877_abnormal_melanocyte_morpholog0.61411273
50MP0000566_synostosis0.60534901
51MP0001485_abnormal_pinna_reflex0.59825863
52MP0003191_abnormal_cellular_cholesterol0.58767213
53MP0000627_abnormal_mammary_gland0.55658190
54MP0001661_extended_life_span0.55490289
55MP0005451_abnormal_body_composition0.55283232
56MP0002282_abnormal_trachea_morphology0.53480181
57MP0005023_abnormal_wound_healing0.50320835
58MP0003755_abnormal_palate_morphology0.49332865
59MP0001784_abnormal_fluid_regulation0.45107100
60MP0002970_abnormal_white_adipose0.44793669
61MP0002163_abnormal_gland_morphology0.42236498
62MP0002111_abnormal_tail_morphology0.39671909
63MP0002249_abnormal_larynx_morphology0.38376446
64MP0005379_endocrine/exocrine_gland_phen0.37424540
65MP0009379_abnormal_foot_pigmentation0.37153313
66MP0005075_abnormal_melanosome_morpholog0.36208106
67MP0010352_gastrointestinal_tract_polyps0.34852895
68MP0005535_abnormal_body_temperature0.33394661
69MP0000678_abnormal_parathyroid_gland0.32638483
70MP0004272_abnormal_basement_membrane0.32391516
71MP0002177_abnormal_outer_ear0.31521380
72MP0009840_abnormal_foam_cell0.31233196
73MP0003385_abnormal_body_wall0.30186220
74MP0000537_abnormal_urethra_morphology0.29194082
75MP0000465_gastrointestinal_hemorrhage0.28087983
76MP0003646_muscle_fatigue0.27384729
77MP0003763_abnormal_thymus_physiology0.26813470
78MP0005503_abnormal_tendon_morphology0.25208329
79MP0003950_abnormal_plasma_membrane0.24743196
80MP0001984_abnormal_olfaction0.24615678
81MP0003329_amyloid_beta_deposits0.24365849
82MP0009780_abnormal_chondrocyte_physiolo0.23820785
83MP0005452_abnormal_adipose_tissue0.23785699
84MP0002697_abnormal_eye_size0.23392474
85MP0002009_preneoplasia0.23049720
86MP0004782_abnormal_surfactant_physiolog0.22534790
87MP0005248_abnormal_Harderian_gland0.21321387
88MP0001905_abnormal_dopamine_level0.20885999
89MP0001919_abnormal_reproductive_system0.20460698
90MP0004019_abnormal_vitamin_homeostasis0.20227821
91MP0003300_gastrointestinal_ulcer0.19465883
92MP0005646_abnormal_pituitary_gland0.19392913
93MP0006054_spinal_hemorrhage0.18955921
94MP0000432_abnormal_head_morphology0.17006831
95MP0004742_abnormal_vestibular_system0.16739415
96MP0003011_delayed_dark_adaptation0.16280368
97MP0003448_altered_tumor_morphology0.15991621
98MP0005666_abnormal_adipose_tissue0.14821908
99MP0001879_abnormal_lymphatic_vessel0.14380449
100MP0003935_abnormal_craniofacial_develop0.13782810
101MP0004858_abnormal_nervous_system0.13775926
102MP0003638_abnormal_response/metabolism_0.13540039
103MP0005375_adipose_tissue_phenotype0.13449375
104MP0000604_amyloidosis0.12810006
105MP0002233_abnormal_nose_morphology0.11797384
106MP0002006_tumorigenesis0.10848944
107MP0005076_abnormal_cell_differentiation0.10508905
108MP0001958_emphysema0.10460945
109MP0003075_altered_response_to0.10083727
110MP0002166_altered_tumor_susceptibility0.09992517
111MP0005193_abnormal_anterior_eye0.09946372
112MP0005367_renal/urinary_system_phenotyp0.09166606
113MP0000516_abnormal_urinary_system0.09166606
114MP0003045_fibrosis0.09155609
115MP0002971_abnormal_brown_adipose0.07396346
116MP0008569_lethality_at_weaning0.07355676
117MP0009703_decreased_birth_body0.07316642
118MP0000462_abnormal_digestive_system0.07265692
119MP0000013_abnormal_adipose_tissue0.06624487
120MP0000733_abnormal_muscle_development0.06518501
121MP0006072_abnormal_retinal_apoptosis0.06463621
122MP0009384_cardiac_valve_regurgitation0.06443925
123MP0004147_increased_porphyrin_level0.06357539
124MP0005508_abnormal_skeleton_morphology0.06332564
125MP0000751_myopathy0.06135119
126MP0000358_abnormal_cell_content/0.05963262
127MP0002118_abnormal_lipid_homeostasis0.05946402
128MP0010368_abnormal_lymphatic_system0.05902090
129MP0001186_pigmentation_phenotype0.03216175
130MP0005332_abnormal_amino_acid0.02634084
131MP0005636_abnormal_mineral_homeostasis-0.0381189
132MP0002139_abnormal_hepatobiliary_system-0.0380352
133MP0006138_congestive_heart_failure-0.0360069
134MP0005253_abnormal_eye_physiology-0.0179592
135MP0004043_abnormal_pH_regulation-0.0169965
136MP0001756_abnormal_urination-0.0161898
137MP0001881_abnormal_mammary_gland-0.0153418
138MP0000685_abnormal_immune_system-0.0018310

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)8.82965382
2Nail dystrophy (HP:0008404)7.43848487
3Abnormality of nail color (HP:0100643)6.49566007
4Absent eyebrow (HP:0002223)6.39051709
5Fragile nails (HP:0001808)5.58581323
6Abnormal hair laboratory examination (HP:0003328)5.57896901
7Absent hair (HP:0002298)5.38723182
8Fine hair (HP:0002213)5.25665368
9Alopecia of scalp (HP:0002293)5.11203612
10Palmoplantar hyperkeratosis (HP:0000972)4.98930000
11Onycholysis (HP:0001806)4.81669050
12Thick nail (HP:0001805)4.76471859
13Increased IgE level (HP:0003212)4.69763479
14Palmar hyperkeratosis (HP:0010765)4.69710857
15Plantar hyperkeratosis (HP:0007556)4.53813632
16Follicular hyperkeratosis (HP:0007502)4.34671804
17Right ventricular cardiomyopathy (HP:0011663)4.20814882
18Abnormality of secondary sexual hair (HP:0009888)3.96613286
19Abnormality of the axillary hair (HP:0100134)3.96613286
20Erythema (HP:0010783)3.54194841
21Sparse eyelashes (HP:0000653)3.52968839
22Oral leukoplakia (HP:0002745)3.49063319
23Milia (HP:0001056)3.30152097
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24086227
25Amelogenesis imperfecta (HP:0000705)3.01926600
26Erythroderma (HP:0001019)3.01500979
27Abnormality of the frontal sinuses (HP:0002687)3.01218223
28Parakeratosis (HP:0001036)2.97481302
29Ridged nail (HP:0001807)2.76154700
30Curly hair (HP:0002212)2.69621383
31Congenital ichthyosiform erythroderma (HP:0007431)2.63711714
32Intention tremor (HP:0002080)2.58308762
33Abnormal blistering of the skin (HP:0008066)2.52940705
34Congenital, generalized hypertrichosis (HP:0004540)2.52189094
35Natal tooth (HP:0000695)2.42175292
36Neck muscle weakness (HP:0000467)2.39451051
37Aplasia cutis congenita (HP:0001057)2.38880902
38Dry hair (HP:0011359)2.36167185
39Torticollis (HP:0000473)2.32904779
40Advanced eruption of teeth (HP:0006288)2.31682843
41Hypohidrosis (HP:0000966)2.16448924
42Corneal erosion (HP:0200020)2.13444285
43Palmoplantar keratoderma (HP:0000982)2.09236194
44Ventricular tachycardia (HP:0004756)2.01387884
45Hypotrichosis (HP:0001006)14.8636562
46Abnormality of hair growth rate (HP:0011363)11.1286379
47Slow-growing hair (HP:0002217)11.1286379
48Woolly hair (HP:0002224)10.9859770
49Brittle hair (HP:0002299)10.4016838
50Craniofacial dystonia (HP:0012179)1.96704328
51Pruritus (HP:0000989)1.93274493
52Coarse hair (HP:0002208)1.88637278
53Difficulty walking (HP:0002355)1.84982390
54Abnormality of the pupil (HP:0000615)1.82689244
55Concave nail (HP:0001598)1.81895512
56Focal dystonia (HP:0004373)1.79774970
57Ventricular fibrillation (HP:0001663)1.79331939
58Conjunctival hamartoma (HP:0100780)1.74858018
59Abnormality of the dental root (HP:0006486)1.73238977
60Taurodontia (HP:0000679)1.73238977
61Abnormality of permanent molar morphology (HP:0011071)1.73238977
62Abnormality of the neuromuscular junction (HP:0003398)1.72215728
63Fatigable weakness (HP:0003473)1.72215728
64Abnormality of molar morphology (HP:0011070)1.71286532
65Abnormality of molar (HP:0011077)1.71286532
66Abnormality of the parietal bone (HP:0002696)1.70094811
67Abnormality of dental color (HP:0011073)1.68247375
68Widely patent fontanelles and sutures (HP:0004492)1.62330036
69Recurrent corneal erosions (HP:0000495)1.62016787
70Absent eyelashes (HP:0000561)1.60304538
71Blepharitis (HP:0000498)1.57203796
72Hyporeflexia of lower limbs (HP:0002600)1.55839698
73Furrowed tongue (HP:0000221)1.53171563
74Abnormality of the dental pulp (HP:0006479)1.51235869
75Hamartoma of the eye (HP:0010568)1.51226746
76Abnormality of the aortic arch (HP:0012303)1.48024010
77Unilateral renal agenesis (HP:0000122)1.46764490
78Amniotic constriction ring (HP:0009775)1.46369207
79Abnormality of placental membranes (HP:0011409)1.46369207
80Sudden death (HP:0001699)1.46164603
81Lip pit (HP:0100267)1.45565056
82Acanthosis nigricans (HP:0000956)1.44944084
83Heterogeneous (HP:0001425)1.43492731
84Carious teeth (HP:0000670)1.42862341
85Gangrene (HP:0100758)1.42811817
86Ectropion (HP:0000656)1.40496796
87Anonychia (HP:0001798)1.40216762
88Hypergammaglobulinemia (HP:0010702)1.38177256
89Keratoconjunctivitis sicca (HP:0001097)1.37884559
90Urticaria (HP:0001025)1.36022158
91Achilles tendon contracture (HP:0001771)1.33942292
92Distal lower limb muscle weakness (HP:0009053)1.31675780
93Abnormality of the fingernails (HP:0001231)1.29928746
94Autoamputation (HP:0001218)1.28595971
95Laryngomalacia (HP:0001601)1.28559601
96Neonatal onset (HP:0003623)1.28545159
97Atrophic scars (HP:0001075)1.28108208
98Craniofacial hyperostosis (HP:0004493)1.27435558
99Abnormality of the Achilles tendon (HP:0005109)1.25824656
100Keratoconjunctivitis (HP:0001096)1.21186147
101Variable expressivity (HP:0003828)1.20809601
102Lack of skin elasticity (HP:0100679)1.19632702
103Hyperhidrosis (HP:0000975)1.18246113
104Round ear (HP:0100830)1.17683463
105Increased connective tissue (HP:0009025)1.17312884
106Multifactorial inheritance (HP:0001426)1.16564885
107Sparse scalp hair (HP:0002209)1.16035400
108Selective tooth agenesis (HP:0001592)1.15244306
109Corneal dystrophy (HP:0001131)1.14835629
110Type 1 muscle fiber predominance (HP:0003803)1.12352570
111Abnormality of the salivary glands (HP:0010286)1.03184678
112Generalized hyperpigmentation (HP:0007440)0.94207468
113Aplasia involving bones of the extremities (HP:0009825)0.86662319
114Aplasia involving bones of the upper limbs (HP:0009823)0.86662319
115Aplasia of the phalanges of the hand (HP:0009802)0.86662319
116Cranial hyperostosis (HP:0004437)0.86653585
117Skin ulcer (HP:0200042)0.84860660
118Septate vagina (HP:0001153)0.81244988
119Acanthocytosis (HP:0001927)0.80982403
120Hypoplastic toenails (HP:0001800)0.76844791
121Conical tooth (HP:0000698)0.76698422
122Melanocytic nevus (HP:0000995)0.74373856
123Dehydration (HP:0001944)0.73880241
124Neonatal death (HP:0003811)0.71465478
125Dry skin (HP:0000958)0.69855195
126Clubbing of toes (HP:0100760)0.66492579
127Hamartoma (HP:0010566)0.66077012
128Nasolacrimal duct obstruction (HP:0000579)0.66019798
129Seborrheic dermatitis (HP:0001051)0.65540219
130Hypoplastic labia majora (HP:0000059)0.65399371
131Preauricular skin tag (HP:0000384)0.63389871
132Split foot (HP:0001839)0.62188678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.32199815
2FER4.25187656
3MAPKAPK34.16282909
4ERN13.88202769
5MAP3K63.68837689
6STK393.16441727
7EPHB23.07491534
8TAOK13.01493253
9MAP3K32.74579130
10TRIB32.65196677
11LATS12.42115249
12MAP3K22.32111552
13MAP3K112.18801918
14RPS6KB22.00459687
15EEF2K1.92703152
16MYLK1.85176659
17TTN1.75912795
18MAP2K61.74144635
19PIK3CG1.70617901
20EPHB11.69007297
21MAPK71.63840682
22LATS21.62666297
23LMTK21.62376916
24OXSR11.58905093
25GRK11.54359613
26FGFR41.38808191
27NLK1.35502648
28MAP3K11.34547539
29BCR1.32876893
30NME11.29734261
31MST1R1.28740949
32RIPK11.25882147
33FGFR21.24778530
34FGFR11.24133634
35BMX1.21009884
36BLK1.19359449
37MAP2K31.17213523
38KSR21.15487437
39BCKDK1.15432486
40TNIK1.15305399
41PRKD21.14196468
42PKN21.14026610
43CASK1.12928675
44ABL21.12699269
45CDK61.10088456
46FGFR31.08747388
47MAPKAPK21.08551638
48LRRK21.06009033
49PDGFRA1.05373280
50PRPF4B1.04978969
51PINK11.04925238
52MAP3K71.02010920
53PTK60.99181179
54FRK0.95314453
55MAP3K90.93806491
56PBK0.92352498
57MAP2K40.90661738
58MAP3K120.89085134
59PRKCE0.88666222
60RPS6KA40.87343740
61PTK20.82364296
62SIK10.82282157
63RPS6KB10.78986250
64STK380.78978463
65SMG10.77908070
66MAP2K10.75947629
67MET0.73333399
68PIM20.71541961
69STK38L0.71330714
70TESK10.69602886
71IKBKB0.69396618
72SGK20.69292644
73PAK40.68794995
74PHKG10.68645185
75PHKG20.68645185
76PRKD10.67832252
77DDR20.67235672
78PAK30.66941907
79DYRK1B0.65662984
80TRPM70.65545411
81NTRK20.63050181
82EPHA40.62854817
83SGK4940.61809588
84SGK2230.61809588
85TYK20.60649599
86CDK190.60546050
87MAP3K100.58373048
88ADRBK10.57937618
89MAP3K50.56800036
90EPHA30.55566583
91PRKCH0.54946530
92JAK10.54087732
93PRKCI0.53821078
94ERBB40.52158996
95TYRO30.51663682
96TGFBR10.51134616
97PDK20.50817515
98PRKAA20.50384997
99DAPK20.50053303
100PAK20.49596933
101RET0.49089665
102OBSCN0.47673025
103PAK60.46722230
104ERBB20.46210886
105MAPK120.45393191
106RPS6KA10.44627583
107MINK10.44487753
108ALK0.43992062
109MST40.42714890
110STK30.42384270
111PIK3CA0.41486290
112HIPK20.41445870
113SGK30.40371590
114MARK20.40358668
115PASK0.39593517
116CDK70.38470967
117GSK3A0.38127178
118ERBB30.36733121
119NEK10.36732804
120CSNK1E0.36728836
121MAP2K20.36185868
122MAPK40.35461086
123JAK20.35342276
124CLK10.35099828
125WNK40.35099558
126ILK0.34612912
127STK240.32289940
128GRK60.31079957
129MAP3K80.30968682
130LIMK10.30139660
131KIT0.30128746
132FYN0.30000259
133TGFBR20.29670879
134AKT20.26597306
135HCK0.25836662
136ADRBK20.25685867
137SRC0.25614798
138UHMK10.24958505
139SGK10.24792159
140CDC42BPA0.24276220
141CSNK1A10.23259441
142MAPKAPK50.23117460
143ROCK20.22478549
144ROCK10.21821620
145PRKACG0.21135839
146STK110.20867442
147MAP3K40.20728161
148IGF1R0.20156776
149PRKACA0.19888792

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.01066829
2Linoleic acid metabolism_Homo sapiens_hsa005914.96081503
3Vitamin digestion and absorption_Homo sapiens_hsa049774.17487774
4Fatty acid biosynthesis_Homo sapiens_hsa000613.26468221
5Fat digestion and absorption_Homo sapiens_hsa049753.21652207
6Fatty acid elongation_Homo sapiens_hsa000622.81536890
7Ether lipid metabolism_Homo sapiens_hsa005652.62585413
8Basal cell carcinoma_Homo sapiens_hsa052172.12837327
9Arachidonic acid metabolism_Homo sapiens_hsa005901.96914612
10Retinol metabolism_Homo sapiens_hsa008301.94047338
11Phenylalanine metabolism_Homo sapiens_hsa003601.89994629
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.80001585
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.79136403
14VEGF signaling pathway_Homo sapiens_hsa043701.69880077
15Melanogenesis_Homo sapiens_hsa049161.52765419
16Axon guidance_Homo sapiens_hsa043601.52100857
17Glycerolipid metabolism_Homo sapiens_hsa005611.50993580
18Histidine metabolism_Homo sapiens_hsa003401.43703616
19Caffeine metabolism_Homo sapiens_hsa002321.39249500
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33960776
21Hedgehog signaling pathway_Homo sapiens_hsa043401.31446522
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.30524285
23Bladder cancer_Homo sapiens_hsa052191.30298577
24Glioma_Homo sapiens_hsa052141.29479605
25Thyroid cancer_Homo sapiens_hsa052161.26426703
26Proteoglycans in cancer_Homo sapiens_hsa052051.25979440
27GnRH signaling pathway_Homo sapiens_hsa049121.23928494
28Hippo signaling pathway_Homo sapiens_hsa043901.18818319
29Acute myeloid leukemia_Homo sapiens_hsa052211.18213528
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16976983
31Pancreatic secretion_Homo sapiens_hsa049721.14551622
32Tight junction_Homo sapiens_hsa045301.08690915
33Dorso-ventral axis formation_Homo sapiens_hsa043201.07113371
34PPAR signaling pathway_Homo sapiens_hsa033201.04011645
35Mineral absorption_Homo sapiens_hsa049781.03980021
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02656789
37ECM-receptor interaction_Homo sapiens_hsa045121.02556857
38Collecting duct acid secretion_Homo sapiens_hsa049661.01767389
39Steroid biosynthesis_Homo sapiens_hsa001001.01054920
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98401685
41Long-term potentiation_Homo sapiens_hsa047200.97115962
42Adherens junction_Homo sapiens_hsa045200.96789693
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96620663
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.95161347
45Nitrogen metabolism_Homo sapiens_hsa009100.94233622
46Tyrosine metabolism_Homo sapiens_hsa003500.93736313
47Ovarian steroidogenesis_Homo sapiens_hsa049130.89617646
48Peroxisome_Homo sapiens_hsa041460.88008163
49Pertussis_Homo sapiens_hsa051330.87683092
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86995446
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84148409
52beta-Alanine metabolism_Homo sapiens_hsa004100.83395701
53Ras signaling pathway_Homo sapiens_hsa040140.82957540
54Non-small cell lung cancer_Homo sapiens_hsa052230.81998357
55Long-term depression_Homo sapiens_hsa047300.80921262
56Endometrial cancer_Homo sapiens_hsa052130.80725643
57Estrogen signaling pathway_Homo sapiens_hsa049150.80331049
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80193987
59Amoebiasis_Homo sapiens_hsa051460.77548238
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.77331662
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76098214
62Arginine biosynthesis_Homo sapiens_hsa002200.74876331
63Staphylococcus aureus infection_Homo sapiens_hsa051500.73990931
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72821056
65Wnt signaling pathway_Homo sapiens_hsa043100.71621248
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69107547
67Amphetamine addiction_Homo sapiens_hsa050310.68999800
68Renin secretion_Homo sapiens_hsa049240.68601866
69Lysosome_Homo sapiens_hsa041420.68346328
70Gastric acid secretion_Homo sapiens_hsa049710.67480091
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65984326
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.65711636
73Phototransduction_Homo sapiens_hsa047440.64347200
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.63893582
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63558736
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62500835
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61023076
78MicroRNAs in cancer_Homo sapiens_hsa052060.59766190
79Hepatitis C_Homo sapiens_hsa051600.57818686
80Insulin resistance_Homo sapiens_hsa049310.57036980
81Fatty acid metabolism_Homo sapiens_hsa012120.56933081
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55982601
83Protein digestion and absorption_Homo sapiens_hsa049740.55320193
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.54326995
85Rap1 signaling pathway_Homo sapiens_hsa040150.54178338
86Salmonella infection_Homo sapiens_hsa051320.53961035
87Circadian entrainment_Homo sapiens_hsa047130.53322032
88Serotonergic synapse_Homo sapiens_hsa047260.52791117
89Gap junction_Homo sapiens_hsa045400.51835853
90Pyruvate metabolism_Homo sapiens_hsa006200.51549229
91Salivary secretion_Homo sapiens_hsa049700.49932760
92Focal adhesion_Homo sapiens_hsa045100.49734501
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49373594
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48903192
95Platelet activation_Homo sapiens_hsa046110.48625305
96Glucagon signaling pathway_Homo sapiens_hsa049220.47746793
97Renal cell carcinoma_Homo sapiens_hsa052110.47353762
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.46687027
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46482763
100Oxytocin signaling pathway_Homo sapiens_hsa049210.46092664
101Chemical carcinogenesis_Homo sapiens_hsa052040.45445436
102ErbB signaling pathway_Homo sapiens_hsa040120.45067614
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44685816
104Fatty acid degradation_Homo sapiens_hsa000710.44374787
105Toxoplasmosis_Homo sapiens_hsa051450.40452120
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40340672
107Butanoate metabolism_Homo sapiens_hsa006500.39339598
108Tuberculosis_Homo sapiens_hsa051520.39244082
109TGF-beta signaling pathway_Homo sapiens_hsa043500.39126905
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38606655
111Prion diseases_Homo sapiens_hsa050200.37857075
112Dopaminergic synapse_Homo sapiens_hsa047280.36397974
113Olfactory transduction_Homo sapiens_hsa047400.36163025
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.36154002
115Prolactin signaling pathway_Homo sapiens_hsa049170.35904373
116Notch signaling pathway_Homo sapiens_hsa043300.35715251
117Chronic myeloid leukemia_Homo sapiens_hsa052200.35369807
118p53 signaling pathway_Homo sapiens_hsa041150.35337009
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34569920
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31715460
121Insulin signaling pathway_Homo sapiens_hsa049100.31625594
122Sphingolipid metabolism_Homo sapiens_hsa006000.31310950
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27865551
124Propanoate metabolism_Homo sapiens_hsa006400.26911393
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24283602
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.21465529
127Synaptic vesicle cycle_Homo sapiens_hsa047210.21354289
128Malaria_Homo sapiens_hsa051440.20813631
129Vibrio cholerae infection_Homo sapiens_hsa051100.20485694
130Calcium signaling pathway_Homo sapiens_hsa040200.17181806
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.16761420
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15727281
133Choline metabolism in cancer_Homo sapiens_hsa052310.15722546
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.15046283
135Glutamatergic synapse_Homo sapiens_hsa047240.13339924
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11751528
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10921071
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09916104
139Glutathione metabolism_Homo sapiens_hsa004800.08221237

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