ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.96771611
2	DNA deamination (GO:0045006)	4.89573209
3	L-fucose catabolic process (GO:0042355)	4.59230312
4	fucose catabolic process (GO:0019317)	4.59230312
5	L-fucose metabolic process (GO:0042354)	4.59230312
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.79155485
7	water-soluble vitamin biosynthetic process (GO:0042364)	3.75748256
8	pyrimidine nucleobase catabolic process (GO:0006208)	3.73247240
9	negative regulation of telomere maintenance (GO:0032205)	3.56864044
10	piRNA metabolic process (GO:0034587)	3.52638851
11	kidney morphogenesis (GO:0060993)	3.51773115
12	indolalkylamine metabolic process (GO:0006586)	3.51087930
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50067436
14	tryptophan catabolic process (GO:0006569)	3.47974623
15	indole-containing compound catabolic process (GO:0042436)	3.47974623
16	indolalkylamine catabolic process (GO:0046218)	3.47974623
17	regulation of mesoderm development (GO:2000380)	3.45456693
18	cellular ketone body metabolic process (GO:0046950)	3.43734054
19	cellular anion homeostasis (GO:0030002)	3.42338443
20	response to pheromone (GO:0019236)	3.37313688
21	nucleobase catabolic process (GO:0046113)	3.30441786
22	detection of light stimulus involved in visual perception (GO:0050908)	3.30042558
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.30042558
24	kynurenine metabolic process (GO:0070189)	3.25447329
25	protein polyglutamylation (GO:0018095)	3.25339265
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24910190
27	NADH dehydrogenase complex assembly (GO:0010257)	3.17820043
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.17820043
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.17820043
30	nonmotile primary cilium assembly (GO:0035058)	3.14537535
31	regulation of cilium movement (GO:0003352)	3.13643684
32	somite rostral/caudal axis specification (GO:0032525)	3.13038131
33	axoneme assembly (GO:0035082)	3.12168669
34	platelet dense granule organization (GO:0060155)	3.11529379
35	protein complex biogenesis (GO:0070271)	3.10289520
36	positive regulation of defense response to virus by host (GO:0002230)	3.09541757
37	protein-cofactor linkage (GO:0018065)	3.08168527
38	ketone body metabolic process (GO:1902224)	3.02381582
39	negative regulation of mast cell activation (GO:0033004)	3.00917063
40	preassembly of GPI anchor in ER membrane (GO:0016254)	2.97933743
41	tryptophan metabolic process (GO:0006568)	2.97625126
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94300933
43	respiratory chain complex IV assembly (GO:0008535)	2.93502037
44	epithelial cilium movement (GO:0003351)	2.91852392
45	cellular response to ATP (GO:0071318)	2.90358232
46	cytidine deamination (GO:0009972)	2.87243313
47	cytidine metabolic process (GO:0046087)	2.87243313
48	cytidine catabolic process (GO:0006216)	2.87243313
49	positive regulation of fatty acid transport (GO:2000193)	2.84043954
50	glycerophospholipid catabolic process (GO:0046475)	2.83533329
51	positive regulation of prostaglandin secretion (GO:0032308)	2.82991080
52	regulation of microtubule-based movement (GO:0060632)	2.82040039
53	adaptation of signaling pathway (GO:0023058)	2.79719834
54	neuronal action potential (GO:0019228)	2.76082659
55	ubiquinone biosynthetic process (GO:0006744)	2.74252949
56	DNA methylation involved in gamete generation (GO:0043046)	2.73491662
57	indole-containing compound metabolic process (GO:0042430)	2.72777668
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.72148861
59	ATP synthesis coupled proton transport (GO:0015986)	2.72148861
60	cytochrome complex assembly (GO:0017004)	2.70212685
61	cellular biogenic amine catabolic process (GO:0042402)	2.67561478
62	amine catabolic process (GO:0009310)	2.67561478
63	sulfation (GO:0051923)	2.63762197
64	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61680749
65	photoreceptor cell maintenance (GO:0045494)	2.61296267
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.58884778
67	auditory receptor cell stereocilium organization (GO:0060088)	2.57397448
68	rhodopsin mediated signaling pathway (GO:0016056)	2.57325194
69	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.56842175
70	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.56636294
71	regulation of mitotic spindle checkpoint (GO:1903504)	2.56588654
72	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.56588654
73	endoderm formation (GO:0001706)	2.55039174
74	ubiquinone metabolic process (GO:0006743)	2.54871888
75	retinal cone cell development (GO:0046549)	2.51928278
76	primary amino compound metabolic process (GO:1901160)	2.51891296
77	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.51404060
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.51404060
79	exogenous drug catabolic process (GO:0042738)	2.51018927
80	fucosylation (GO:0036065)	2.50937590
81	secondary heart field specification (GO:0003139)	2.50850071
82	heart field specification (GO:0003128)	2.50850071
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50814650
84	nephron epithelium morphogenesis (GO:0072088)	2.50092086
85	nephron tubule morphogenesis (GO:0072078)	2.50092086
86	regulation of neurotransmitter uptake (GO:0051580)	2.49875758
87	positive regulation of icosanoid secretion (GO:0032305)	2.49733813
88	inner ear receptor stereocilium organization (GO:0060122)	2.48711857
89	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.47980244
90	synaptic transmission, cholinergic (GO:0007271)	2.47335469
91	somite development (GO:0061053)	2.47040581
92	neural tube formation (GO:0001841)	2.46330870
93	regulation of action potential (GO:0098900)	2.45965022
94	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45356603
95	cornea development in camera-type eye (GO:0061303)	2.45237425
96	retinal ganglion cell axon guidance (GO:0031290)	2.44636315
97	photoreceptor cell development (GO:0042461)	2.43009957
98	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.42587983
99	reflex (GO:0060004)	2.42426380
100	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.42098396

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.33605671
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.10636205
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16802180
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.72761986
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42217357
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27036312
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25662995
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.24049315
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22443681
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.19365890
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12130154
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.09072277
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02092051
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97595371
15	P300_19829295_ChIP-Seq_ESCs_Human	1.90279549
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83488391
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80572356
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78896565
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77532814
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.76568227
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72474379
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72229293
23	EWS_26573619_Chip-Seq_HEK293_Human	1.71093675
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.68141212
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.67495081
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.64876357
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61296996
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60434565
29	FUS_26573619_Chip-Seq_HEK293_Human	1.60380069
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52169570
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.47324591
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44657522
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42070261
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41566578
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.40951295
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39032290
37	AR_25329375_ChIP-Seq_VCAP_Human	1.37212823
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36242221
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36242221
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36113892
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.36113892
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36092340
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34165244
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31961093
45	STAT3_23295773_ChIP-Seq_U87_Human	1.31401114
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29688154
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.28859892
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.28712278
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27679341
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27258460
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27145246
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26837483
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26816635
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.26757667
55	TCF4_23295773_ChIP-Seq_U87_Human	1.26031342
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25136397
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23666538
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.23650929
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.22675114
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20880542
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.20588690
62	NCOR_22424771_ChIP-Seq_293T_Human	1.20517060
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19706343
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19508826
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19508826
66	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.19504126
67	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17974320
68	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17948354
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.17745231
70	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17350472
71	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16428076
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14231141
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13897181
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13337066
75	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12438112
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12438112
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12437109
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12361521
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11285160
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.10821915
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10630909
82	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09863689
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09522904
84	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08966530
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08698348
86	AR_20517297_ChIP-Seq_VCAP_Human	1.08362178
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.07683681
88	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.06803687
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05382276
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04315240
91	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03816105
92	ERA_21632823_ChIP-Seq_H3396_Human	1.01706315
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00108459
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00021551
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96453572
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95266928
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.94228421
98	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93497598
99	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.93011145
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92702712

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.61107128
2	MP0003195_calcinosis	2.61987218
3	MP0006072_abnormal_retinal_apoptosis	2.47263172
4	MP0008875_abnormal_xenobiotic_pharmacok	2.44558627
5	MP0005551_abnormal_eye_electrophysiolog	2.42951844
6	MP0003787_abnormal_imprinting	2.37289418
7	MP0001968_abnormal_touch/_nociception	2.36678567
8	MP0002876_abnormal_thyroid_physiology	2.28205034
9	MP0004885_abnormal_endolymph	2.26787668
10	MP0002102_abnormal_ear_morphology	2.19271727
11	MP0002837_dystrophic_cardiac_calcinosis	2.18764659
12	MP0002234_abnormal_pharynx_morphology	2.17664142
13	MP0006292_abnormal_olfactory_placode	2.14701683
14	MP0008872_abnormal_physiological_respon	2.08902065
15	MP0003283_abnormal_digestive_organ	2.02762073
16	MP0005645_abnormal_hypothalamus_physiol	2.00728219
17	MP0002736_abnormal_nociception_after	1.94699157
18	MP0002638_abnormal_pupillary_reflex	1.92160724
19	MP0009046_muscle_twitch	1.90302425
20	MP0006276_abnormal_autonomic_nervous	1.88130105
21	MP0001986_abnormal_taste_sensitivity	1.87368244
22	MP0004742_abnormal_vestibular_system	1.84743467
23	MP0009745_abnormal_behavioral_response	1.82840884
24	MP0003880_abnormal_central_pattern	1.76265732
25	MP0005253_abnormal_eye_physiology	1.75455277
26	MP0004142_abnormal_muscle_tone	1.71487860
27	MP0002272_abnormal_nervous_system	1.68465724
28	MP0002254_reproductive_system_inflammat	1.65698604
29	MP0001984_abnormal_olfaction	1.63916306
30	MP0001501_abnormal_sleep_pattern	1.61356339
31	MP0005646_abnormal_pituitary_gland	1.59765602
32	MP0000427_abnormal_hair_cycle	1.59703317
33	MP0000569_abnormal_digit_pigmentation	1.50636605
34	MP0002653_abnormal_ependyma_morphology	1.50480620
35	MP0002138_abnormal_hepatobiliary_system	1.47429415
36	MP0002938_white_spotting	1.47129251
37	MP0005084_abnormal_gallbladder_morpholo	1.45044255
38	MP0002557_abnormal_social/conspecific_i	1.43544334
39	MP0001485_abnormal_pinna_reflex	1.43142626
40	MP0002735_abnormal_chemical_nociception	1.43120499
41	MP0002572_abnormal_emotion/affect_behav	1.41805625
42	MP0003646_muscle_fatigue	1.40076047
43	MP0001486_abnormal_startle_reflex	1.39183981
44	MP0004147_increased_porphyrin_level	1.38664639
45	MP0004133_heterotaxia	1.33452694
46	MP0005389_reproductive_system_phenotype	1.32005536
47	MP0001873_stomach_inflammation	1.31190476
48	MP0004043_abnormal_pH_regulation	1.30164228
49	MP0002163_abnormal_gland_morphology	1.29293860
50	MP0001970_abnormal_pain_threshold	1.27999255
51	MP0001905_abnormal_dopamine_level	1.27543819
52	MP0000631_abnormal_neuroendocrine_gland	1.26283968
53	MP0002064_seizures	1.25749304
54	MP0001919_abnormal_reproductive_system	1.25448830
55	MP0005423_abnormal_somatic_nervous	1.25440564
56	MP0003122_maternal_imprinting	1.20486165
57	MP0002063_abnormal_learning/memory/cond	1.18852826
58	MP0003011_delayed_dark_adaptation	1.16763442
59	MP0003635_abnormal_synaptic_transmissio	1.15651565
60	MP0002733_abnormal_thermal_nociception	1.14816142
61	MP0002909_abnormal_adrenal_gland	1.14796796
62	MP0002067_abnormal_sensory_capabilities	1.12060456
63	MP0005195_abnormal_posterior_eye	1.11993130
64	MP0001529_abnormal_vocalization	1.10872926
65	MP0002160_abnormal_reproductive_system	1.09177746
66	MP0003121_genomic_imprinting	1.09143707
67	MP0004924_abnormal_behavior	1.09143637
68	MP0005386_behavior/neurological_phenoty	1.09143637
69	MP0005379_endocrine/exocrine_gland_phen	1.07391893
70	MP0002928_abnormal_bile_duct	1.05737913
71	MP0001502_abnormal_circadian_rhythm	1.05710542
72	MP0005377_hearing/vestibular/ear_phenot	1.05602399
73	MP0003878_abnormal_ear_physiology	1.05602399
74	MP0002734_abnormal_mechanical_nocicepti	1.03525441
75	MP0004145_abnormal_muscle_electrophysio	1.02254001
76	MP0000372_irregular_coat_pigmentation	1.01553198
77	MP0008775_abnormal_heart_ventricle	1.01386060
78	MP0000230_abnormal_systemic_arterial	0.99749839
79	MP0008995_early_reproductive_senescence	0.97550443
80	MP0002184_abnormal_innervation	0.97053208
81	MP0002277_abnormal_respiratory_mucosa	0.95498276
82	MP0002752_abnormal_somatic_nervous	0.94637980
83	MP0002693_abnormal_pancreas_physiology	0.94357031
84	MP0000778_abnormal_nervous_system	0.88182216
85	MP0008789_abnormal_olfactory_epithelium	0.87821013
86	MP0002229_neurodegeneration	0.84667182
87	MP0003252_abnormal_bile_duct	0.82300677
88	MP0000026_abnormal_inner_ear	0.80691806
89	MP0005167_abnormal_blood-brain_barrier	0.78937328
90	MP0005332_abnormal_amino_acid	0.78711437
91	MP0001944_abnormal_pancreas_morphology	0.78285891
92	MP0003698_abnormal_male_reproductive	0.77485310
93	MP0003315_abnormal_perineum_morphology	0.76968684
94	MP0009780_abnormal_chondrocyte_physiolo	0.75492174
95	MP0005174_abnormal_tail_pigmentation	0.74466003
96	MP0005671_abnormal_response_to	0.74290024
97	MP0001440_abnormal_grooming_behavior	0.73802066
98	MP0001963_abnormal_hearing_physiology	0.73718138
99	MP0008058_abnormal_DNA_repair	0.73603152
100	MP0002210_abnormal_sex_determination	0.73547567

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.22629469
2	Molar tooth sign on MRI (HP:0002419)	4.22629469
3	Congenital stationary night blindness (HP:0007642)	4.16577562
4	Pancreatic cysts (HP:0001737)	4.13005677
5	Pancreatic fibrosis (HP:0100732)	3.92084171
6	Nephronophthisis (HP:0000090)	3.74136551
7	True hermaphroditism (HP:0010459)	3.60817769
8	Type II lissencephaly (HP:0007260)	3.25377702
9	Abnormality of the renal cortex (HP:0011035)	3.21901198
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.19142740
11	Abnormality of the renal medulla (HP:0100957)	3.17551658
12	Abnormal drinking behavior (HP:0030082)	2.93759810
13	Polydipsia (HP:0001959)	2.93759810
14	Medial flaring of the eyebrow (HP:0010747)	2.92991453
15	Abolished electroretinogram (ERG) (HP:0000550)	2.90605591
16	Hyperventilation (HP:0002883)	2.82871584
17	Attenuation of retinal blood vessels (HP:0007843)	2.71604121
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65428053
19	Tubular atrophy (HP:0000092)	2.48681740
20	Cystic liver disease (HP:0006706)	2.48587720
21	Chronic hepatic failure (HP:0100626)	2.43217966
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.42019814
23	Absent/shortened dynein arms (HP:0200106)	2.42019814
24	Inability to walk (HP:0002540)	2.41674318
25	Renal cortical cysts (HP:0000803)	2.41259096
26	Polyuria (HP:0000103)	2.40159600
27	Pendular nystagmus (HP:0012043)	2.39170285
28	Autoimmune thrombocytopenia (HP:0001973)	2.34834975
29	Birth length less than 3rd percentile (HP:0003561)	2.34108020
30	Broad-based gait (HP:0002136)	2.30354973
31	Cerebellar dysplasia (HP:0007033)	2.30149812
32	Sclerocornea (HP:0000647)	2.29756151
33	Congenital, generalized hypertrichosis (HP:0004540)	2.26517142
34	Concave nail (HP:0001598)	2.23823538
35	Mitochondrial inheritance (HP:0001427)	2.21231673
36	Pachygyria (HP:0001302)	2.16944146
37	Abnormality of alanine metabolism (HP:0010916)	2.15717340
38	Hyperalaninemia (HP:0003348)	2.15717340
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.15717340
40	Acute necrotizing encephalopathy (HP:0006965)	2.15084510
41	Increased corneal curvature (HP:0100692)	2.14247608
42	Keratoconus (HP:0000563)	2.14247608
43	Gait imbalance (HP:0002141)	2.13325477
44	Increased CSF lactate (HP:0002490)	2.12777385
45	Hypothermia (HP:0002045)	2.12163304
46	Large for gestational age (HP:0001520)	2.12144877
47	Lissencephaly (HP:0001339)	2.10355447
48	Hypomagnesemia (HP:0002917)	2.08812529
49	Gaze-evoked nystagmus (HP:0000640)	2.08687911
50	Anterior segment dysgenesis (HP:0007700)	2.06734847
51	Bony spicule pigmentary retinopathy (HP:0007737)	2.06596790
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.05746285
53	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.04759426
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.03766657
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.03766657
56	Methylmalonic acidemia (HP:0002912)	2.01651725
57	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98537313
58	Congenital primary aphakia (HP:0007707)	1.95630059
59	Methylmalonic aciduria (HP:0012120)	1.95526997
60	Tachypnea (HP:0002789)	1.95313581
61	Anencephaly (HP:0002323)	1.94743926
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94184207
63	Asplenia (HP:0001746)	1.93688979
64	Progressive inability to walk (HP:0002505)	1.93687603
65	Optic disc pallor (HP:0000543)	1.93656605
66	Progressive macrocephaly (HP:0004481)	1.93479297
67	Acute encephalopathy (HP:0006846)	1.93382420
68	Severe muscular hypotonia (HP:0006829)	1.92311509
69	Abnormal urine output (HP:0012590)	1.90936813
70	Patellar aplasia (HP:0006443)	1.90878241
71	Abnormality of the labia minora (HP:0012880)	1.90075868
72	Decreased central vision (HP:0007663)	1.89263311
73	Constricted visual fields (HP:0001133)	1.88289681
74	Stomach cancer (HP:0012126)	1.87975040
75	Congenital hepatic fibrosis (HP:0002612)	1.87722125
76	Male pseudohermaphroditism (HP:0000037)	1.87331966
77	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87125462
78	Agitation (HP:0000713)	1.86603190
79	Nephrogenic diabetes insipidus (HP:0009806)	1.82819413
80	Postaxial foot polydactyly (HP:0001830)	1.82679769
81	Rib fusion (HP:0000902)	1.81643817
82	Hemiparesis (HP:0001269)	1.81403409
83	Abnormal mitochondria in muscle tissue (HP:0008316)	1.80574894
84	3-Methylglutaconic aciduria (HP:0003535)	1.79167859
85	Bile duct proliferation (HP:0001408)	1.79161735
86	Abnormal biliary tract physiology (HP:0012439)	1.79161735
87	Ketoacidosis (HP:0001993)	1.78997530
88	Hepatocellular necrosis (HP:0001404)	1.78921589
89	Hepatic necrosis (HP:0002605)	1.78745822
90	Furrowed tongue (HP:0000221)	1.77923815
91	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77043219
92	Ketosis (HP:0001946)	1.75474538
93	Congenital sensorineural hearing impairment (HP:0008527)	1.75074000
94	Abnormality of renal excretion (HP:0011036)	1.74083493
95	Abnormal number of erythroid precursors (HP:0012131)	1.73170259
96	Decreased circulating renin level (HP:0003351)	1.72961809
97	Retinal dysplasia (HP:0007973)	1.72209770
98	Short tibia (HP:0005736)	1.72029351
99	Intestinal atresia (HP:0011100)	1.71948795
100	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.71713537

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.63572981
2	FRK	4.62098070
3	ADRBK2	3.27866072
4	WNK4	2.91906650
5	WNK3	2.87575570
6	BMPR1B	2.71530069
7	TAOK3	2.66610847
8	GRK1	2.50078634
9	MAP4K2	2.48843068
10	TXK	2.36460445
11	ZAK	2.36190165
12	PIK3CA	2.24693087
13	PINK1	2.18158368
14	CASK	2.00003004
15	INSRR	1.90597801
16	OXSR1	1.89692721
17	NUAK1	1.82389682
18	ACVR1B	1.76728202
19	DAPK2	1.59518574
20	MAPK13	1.56491848
21	STK39	1.27004784
22	PNCK	1.26048416
23	MAP3K4	1.25672281
24	PRKCG	1.22517352
25	PHKG2	1.21785982
26	PHKG1	1.21785982
27	PAK3	1.19514016
28	ADRBK1	1.18948953
29	CDK19	1.18158033
30	BCKDK	1.17771756
31	MUSK	1.15191820
32	MARK1	1.11274713
33	DYRK2	1.11080428
34	MAP2K7	1.05866692
35	TGFBR1	1.04106077
36	MKNK2	1.01732377
37	FGFR2	0.99810917
38	MAP2K6	0.96218520
39	CAMKK2	0.92874268
40	GRK7	0.87629443
41	PRKCI	0.85536158
42	KIT	0.83163656
43	NTRK2	0.81886696
44	IKBKB	0.81378177
45	TIE1	0.78733891
46	PRKCE	0.74649391
47	NTRK3	0.72211887
48	IRAK1	0.71660944
49	CAMK1D	0.69834681
50	CSNK1G2	0.68281699
51	CSNK1G1	0.67944316
52	MAP2K2	0.65759310
53	TNIK	0.64783646
54	PLK2	0.64505951
55	CSNK1G3	0.60890540
56	GRK5	0.56963786
57	PRKCQ	0.55074875
58	MAPK15	0.54309856
59	CAMK1	0.52080359
60	NEK2	0.51527763
61	MAPKAPK3	0.50879727
62	CAMK2A	0.50714974
63	PTK2B	0.50194734
64	PKN1	0.50154588
65	PRKACA	0.49413864
66	RPS6KA5	0.46513537
67	PRKG1	0.45279364
68	STK11	0.45141757
69	TEC	0.45086564
70	CSNK1A1	0.44328260
71	CAMK1G	0.44168074
72	CAMKK1	0.44122028
73	NME1	0.42950369
74	MAP2K4	0.42729944
75	CAMK2D	0.42598357
76	STK16	0.42560094
77	GRK6	0.40708291
78	VRK1	0.40645645
79	EPHB2	0.38989823
80	PRKCH	0.38418862
81	IGF1R	0.38289275
82	ITK	0.38284996
83	SYK	0.37364630
84	MINK1	0.37200452
85	STK38L	0.36743990
86	WNK1	0.36522590
87	PRKCZ	0.35001780
88	PRKCA	0.34357103
89	CSNK1D	0.33962020
90	EPHA3	0.33769432
91	EIF2AK2	0.32625725
92	MAP2K1	0.32304191
93	CSNK1A1L	0.32149260
94	EPHA4	0.31500393
95	CDK3	0.31281803
96	MKNK1	0.29571276
97	MAPKAPK5	0.29555955
98	MST4	0.27949249
99	PAK6	0.27915530
100	PASK	0.27853561

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.05186841
2	Caffeine metabolism_Homo sapiens_hsa00232	2.99760222
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.96657381
4	Phototransduction_Homo sapiens_hsa04744	2.73345936
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.67825435
6	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.39075047
7	Butanoate metabolism_Homo sapiens_hsa00650	2.38038675
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.36575647
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.30953565
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.28661880
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22126505
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20501068
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00342104
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.98440046
15	Nicotine addiction_Homo sapiens_hsa05033	1.91643680
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89860760
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.80156216
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.71937514
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.70317882
20	Protein export_Homo sapiens_hsa03060	1.67618062
21	Parkinsons disease_Homo sapiens_hsa05012	1.59091920
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53667382
23	RNA polymerase_Homo sapiens_hsa03020	1.42241897
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41111250
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.40803728
26	Propanoate metabolism_Homo sapiens_hsa00640	1.33948655
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29513946
28	Basal transcription factors_Homo sapiens_hsa03022	1.28383383
29	Homologous recombination_Homo sapiens_hsa03440	1.27637491
30	Peroxisome_Homo sapiens_hsa04146	1.25537424
31	Insulin secretion_Homo sapiens_hsa04911	1.23587224
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21487581
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17513093
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16620114
35	Morphine addiction_Homo sapiens_hsa05032	1.15670173
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10301514
37	Taste transduction_Homo sapiens_hsa04742	1.10212124
38	Ribosome_Homo sapiens_hsa03010	1.08149454
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.04518933
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03542268
41	Alzheimers disease_Homo sapiens_hsa05010	1.03110497
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03082333
43	Huntingtons disease_Homo sapiens_hsa05016	1.01506068
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.00966119
45	Serotonergic synapse_Homo sapiens_hsa04726	1.00664985
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98130271
47	RNA degradation_Homo sapiens_hsa03018	0.95659943
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.95000623
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.94092706
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92857725
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92846882
52	Olfactory transduction_Homo sapiens_hsa04740	0.91831536
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91545993
54	GABAergic synapse_Homo sapiens_hsa04727	0.89316515
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88192476
56	Retinol metabolism_Homo sapiens_hsa00830	0.87141202
57	One carbon pool by folate_Homo sapiens_hsa00670	0.85852499
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85361269
59	Circadian entrainment_Homo sapiens_hsa04713	0.84403443
60	Allograft rejection_Homo sapiens_hsa05330	0.81109355
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.77692237
62	Asthma_Homo sapiens_hsa05310	0.77370861
63	ABC transporters_Homo sapiens_hsa02010	0.74534056
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73907589
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71245354
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69071377
67	Regulation of autophagy_Homo sapiens_hsa04140	0.69060018
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68570038
69	Salivary secretion_Homo sapiens_hsa04970	0.66768037
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66407969
71	Graft-versus-host disease_Homo sapiens_hsa05332	0.63206048
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.63057490
73	Metabolic pathways_Homo sapiens_hsa01100	0.61919240
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.61225076
75	African trypanosomiasis_Homo sapiens_hsa05143	0.60265593
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59733571
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.54437133
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52421562
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51354483
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49760837
81	Mineral absorption_Homo sapiens_hsa04978	0.48928175
82	Purine metabolism_Homo sapiens_hsa00230	0.48753477
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.47077865
84	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47030713
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.46965099
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45336010
87	Dopaminergic synapse_Homo sapiens_hsa04728	0.44624233
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44478743
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44167950
90	Histidine metabolism_Homo sapiens_hsa00340	0.39275639
91	Circadian rhythm_Homo sapiens_hsa04710	0.39033762
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38641323
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.38612926
94	Fatty acid degradation_Homo sapiens_hsa00071	0.37697115
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34205008
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34154460
97	Sulfur metabolism_Homo sapiens_hsa00920	0.34098124
98	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33868090
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.32110270
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.29440597

KRTAP9-6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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