

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | viral transcription (GO:0019083) | 7.84370711 |
| 2 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.66915113 |
| 3 | cotranslational protein targeting to membrane (GO:0006613) | 7.61647317 |
| 4 | protein targeting to ER (GO:0045047) | 7.56574637 |
| 5 | translational termination (GO:0006415) | 7.56265585 |
| 6 | ribosomal small subunit assembly (GO:0000028) | 7.52554803 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 7.47133338 |
| 8 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 7.21827279 |
| 9 | protein localization to endoplasmic reticulum (GO:0070972) | 7.18146335 |
| 10 | translational elongation (GO:0006414) | 6.35905462 |
| 11 | viral life cycle (GO:0019058) | 5.96716267 |
| 12 | cellular protein complex disassembly (GO:0043624) | 5.81574820 |
| 13 | signal peptide processing (GO:0006465) | 5.57917761 |
| 14 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 5.49220261 |
| 15 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.44344016 |
| 16 | translational initiation (GO:0006413) | 5.43380055 |
| 17 | DNA deamination (GO:0045006) | 5.41330833 |
| 18 | ribosomal large subunit biogenesis (GO:0042273) | 5.41110042 |
| 19 | maturation of SSU-rRNA (GO:0030490) | 5.34977649 |
| 20 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.24991466 |
| 21 | ATP synthesis coupled proton transport (GO:0015986) | 5.24991466 |
| 22 | translation (GO:0006412) | 5.11630145 |
| 23 | protein targeting to membrane (GO:0006612) | 5.02400048 |
| 24 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.94135348 |
| 25 | protein complex disassembly (GO:0043241) | 4.85988365 |
| 26 | macromolecular complex disassembly (GO:0032984) | 4.62726058 |
| 27 | respiratory electron transport chain (GO:0022904) | 4.54872406 |
| 28 | electron transport chain (GO:0022900) | 4.45418579 |
| 29 | GTP biosynthetic process (GO:0006183) | 4.23956676 |
| 30 | ATP biosynthetic process (GO:0006754) | 4.22696898 |
| 31 | proteasome assembly (GO:0043248) | 4.18452319 |
| 32 | protein complex biogenesis (GO:0070271) | 4.15628751 |
| 33 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.14717410 |
| 34 | NADH dehydrogenase complex assembly (GO:0010257) | 4.14717410 |
| 35 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.14717410 |
| 36 | termination of RNA polymerase III transcription (GO:0006386) | 4.05159323 |
| 37 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.05159323 |
| 38 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 4.00775886 |
| 39 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 4.00102569 |
| 40 | hydrogen ion transmembrane transport (GO:1902600) | 3.96234404 |
| 41 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.94904794 |
| 42 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.91275337 |
| 43 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.91275337 |
| 44 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.83152961 |
| 45 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.81325874 |
| 46 | GDP-mannose metabolic process (GO:0019673) | 3.79421571 |
| 47 | mRNA catabolic process (GO:0006402) | 3.75030788 |
| 48 | UTP biosynthetic process (GO:0006228) | 3.74091169 |
| 49 | respiratory chain complex IV assembly (GO:0008535) | 3.73565451 |
| 50 | rRNA modification (GO:0000154) | 3.62797740 |
| 51 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.62390563 |
| 52 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.61319253 |
| 53 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.61006096 |
| 54 | cellular component biogenesis (GO:0044085) | 3.60864729 |
| 55 | regulation of mitochondrial translation (GO:0070129) | 3.60707769 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.59567108 |
| 57 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.55712536 |
| 58 | CTP biosynthetic process (GO:0006241) | 3.55573221 |
| 59 | CTP metabolic process (GO:0046036) | 3.55573221 |
| 60 | establishment of protein localization to membrane (GO:0090150) | 3.53138397 |
| 61 | proton transport (GO:0015992) | 3.49957814 |
| 62 | protein localization to mitochondrion (GO:0070585) | 3.49359468 |
| 63 | protein targeting (GO:0006605) | 3.48619790 |
| 64 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.41911453 |
| 65 | hydrogen transport (GO:0006818) | 3.41419956 |
| 66 | RNA catabolic process (GO:0006401) | 3.39553514 |
| 67 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.38718841 |
| 68 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.38056090 |
| 69 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.36263138 |
| 70 | oxidative phosphorylation (GO:0006119) | 3.30915004 |
| 71 | chaperone-mediated protein transport (GO:0072321) | 3.28654221 |
| 72 | UTP metabolic process (GO:0046051) | 3.27847520 |
| 73 | protein neddylation (GO:0045116) | 3.24138389 |
| 74 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 3.23564080 |
| 75 | cytochrome complex assembly (GO:0017004) | 3.22050108 |
| 76 | intracellular protein transmembrane import (GO:0044743) | 3.21952227 |
| 77 | protein targeting to mitochondrion (GO:0006626) | 3.21309837 |
| 78 | rRNA processing (GO:0006364) | 3.20660291 |
| 79 | inner mitochondrial membrane organization (GO:0007007) | 3.19227925 |
| 80 | establishment of protein localization to organelle (GO:0072594) | 3.18158898 |
| 81 | mitochondrial transport (GO:0006839) | 3.17718006 |
| 82 | protein maturation by protein folding (GO:0022417) | 3.17479671 |
| 83 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.17442769 |
| 84 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.17346885 |
| 85 | mannosylation (GO:0097502) | 3.17247612 |
| 86 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.17111032 |
| 87 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.15220768 |
| 88 | peptidyl-histidine modification (GO:0018202) | 3.14987264 |
| 89 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.14583112 |
| 90 | negative regulation of ligase activity (GO:0051352) | 3.14583112 |
| 91 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.13564655 |
| 92 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.11408366 |
| 93 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.11298048 |
| 94 | cullin deneddylation (GO:0010388) | 3.10220959 |
| 95 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.08262313 |
| 96 | establishment of protein localization to mitochondrion (GO:0072655) | 3.06579089 |
| 97 | rRNA metabolic process (GO:0016072) | 3.05482476 |
| 98 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.03760661 |
| 99 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.03760661 |
| 100 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.03275294 |
| 101 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.01138307 |
| 102 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.00577957 |
| 103 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.00577957 |
| 104 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.00577957 |
| 105 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.96939221 |
| 106 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.96271009 |
| 107 | platelet dense granule organization (GO:0060155) | 2.95616028 |
| 108 | protein deneddylation (GO:0000338) | 2.95348989 |
| 109 | pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208) | 2.92039287 |
| 110 | establishment of integrated proviral latency (GO:0075713) | 2.89290326 |
| 111 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.89110445 |
| 112 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.89110445 |
| 113 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.87640144 |
| 114 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.87420936 |
| 115 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.87420936 |
| 116 | protein-cofactor linkage (GO:0018065) | 2.86781804 |
| 117 | formation of translation preinitiation complex (GO:0001731) | 2.86674873 |
| 118 | pseudouridine synthesis (GO:0001522) | 2.86308034 |
| 119 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.85241803 |
| 120 | iron-sulfur cluster assembly (GO:0016226) | 2.84617176 |
| 121 | metallo-sulfur cluster assembly (GO:0031163) | 2.84617176 |
| 122 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.83808548 |
| 123 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.82556596 |
| 124 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.80628011 |
| 125 | spliceosomal snRNP assembly (GO:0000387) | 2.78303986 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.58747361 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.79558647 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.55365043 |
| 4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.20216469 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.10329468 |
| 6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.91099448 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.82675645 |
| 8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.59175821 |
| 9 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.55885894 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.32563085 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.28279016 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.03551402 |
| 13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.99614535 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.97516792 |
| 15 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.93884569 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.91795184 |
| 17 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.67024782 |
| 18 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.64506987 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.61397300 |
| 20 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.55382892 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.44906783 |
| 22 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.42940676 |
| 23 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.33490553 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.32215393 |
| 25 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.28975397 |
| 26 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.28124658 |
| 27 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.27723731 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.22059546 |
| 29 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.20310114 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.14652237 |
| 31 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.07615242 |
| 32 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.05249903 |
| 33 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.03105122 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.02317020 |
| 35 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.99330643 |
| 36 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.97634863 |
| 37 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.93281132 |
| 38 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.89125332 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.89050924 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.87549497 |
| 41 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.75593616 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.75556344 |
| 43 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.71350394 |
| 44 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.62427789 |
| 45 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.54770812 |
| 46 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.54608055 |
| 47 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.52507895 |
| 48 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49644710 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.37694772 |
| 50 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32670612 |
| 51 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.28547584 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.28469319 |
| 53 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.28241431 |
| 54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.25222228 |
| 55 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.24008432 |
| 56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.21296466 |
| 57 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.19232179 |
| 58 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.18770142 |
| 59 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.18326749 |
| 60 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.16901674 |
| 61 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.14579837 |
| 62 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.13259127 |
| 63 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.13196588 |
| 64 | VDR_22108803_ChIP-Seq_LS180_Human | 1.11198168 |
| 65 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.08691661 |
| 66 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08618028 |
| 67 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.08211217 |
| 68 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06090205 |
| 69 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.03104702 |
| 70 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.03081390 |
| 71 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.03019222 |
| 72 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.01833399 |
| 73 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.00710929 |
| 74 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99820743 |
| 75 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.98473073 |
| 76 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96374371 |
| 77 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.96077905 |
| 78 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.95746454 |
| 79 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95332534 |
| 80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.94849153 |
| 81 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.94812965 |
| 82 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.93547681 |
| 83 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.92649546 |
| 84 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.92215964 |
| 85 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.92054010 |
| 86 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.91455590 |
| 87 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.90983771 |
| 88 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.90630645 |
| 89 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90258482 |
| 90 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.90081441 |
| 91 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.89718515 |
| 92 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.89328356 |
| 93 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.87397716 |
| 94 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.86687597 |
| 95 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.86415878 |
| 96 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.85962932 |
| 97 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.85638422 |
| 98 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.85314141 |
| 99 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.84620913 |
| 100 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.84286503 |
| 101 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.84259538 |
| 102 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 0.83232581 |
| 103 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.82429440 |
| 104 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.82184559 |
| 105 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.82145844 |
| 106 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.81904218 |
| 107 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.81886765 |
| 108 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.81866071 |
| 109 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.81829152 |
| 110 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.81564183 |
| 111 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.81412076 |
| 112 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81346493 |
| 113 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.80498106 |
| 114 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.80412014 |
| 115 | AR_20517297_ChIP-Seq_VCAP_Human | 0.80287838 |
| 116 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.80142549 |
| 117 | ERA_21632823_ChIP-Seq_H3396_Human | 0.79470133 |
| 118 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.78958333 |
| 119 | * LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.73544231 |
| 120 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.73487282 |
| 121 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.72688919 |
| 122 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.69822819 |
| 123 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.68278693 |
| 124 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.67503436 |
| 125 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.67472347 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 7.97682765 |
| 2 | MP0003724_increased_susceptibility_to | 3.19530220 |
| 3 | MP0003693_abnormal_embryo_hatching | 2.75782586 |
| 4 | MP0008875_abnormal_xenobiotic_pharmacok | 2.36762630 |
| 5 | MP0003186_abnormal_redox_activity | 2.27548879 |
| 6 | MP0001986_abnormal_taste_sensitivity | 2.26348653 |
| 7 | MP0000372_irregular_coat_pigmentation | 2.18309270 |
| 8 | MP0004957_abnormal_blastocyst_morpholog | 2.15675300 |
| 9 | MP0003136_yellow_coat_color | 2.12504221 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.10854950 |
| 11 | MP0005220_abnormal_exocrine_pancreas | 2.08280195 |
| 12 | MP0006072_abnormal_retinal_apoptosis | 2.08011163 |
| 13 | MP0002837_dystrophic_cardiac_calcinosis | 2.03603103 |
| 14 | MP0005084_abnormal_gallbladder_morpholo | 2.03312488 |
| 15 | MP0003195_calcinosis | 2.00972707 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 1.94460392 |
| 17 | MP0009785_altered_susceptibility_to | 1.93107573 |
| 18 | MP0008932_abnormal_embryonic_tissue | 1.85921610 |
| 19 | MP0005379_endocrine/exocrine_gland_phen | 1.74623201 |
| 20 | MP0005671_abnormal_response_to | 1.72761721 |
| 21 | MP0006036_abnormal_mitochondrial_physio | 1.71925191 |
| 22 | MP0008995_early_reproductive_senescence | 1.70246612 |
| 23 | MP0001529_abnormal_vocalization | 1.70175884 |
| 24 | MP0002938_white_spotting | 1.69900830 |
| 25 | MP0002102_abnormal_ear_morphology | 1.68978234 |
| 26 | MP0002163_abnormal_gland_morphology | 1.65808486 |
| 27 | MP0000490_abnormal_crypts_of | 1.60489950 |
| 28 | MP0008872_abnormal_physiological_respon | 1.59684374 |
| 29 | MP0005075_abnormal_melanosome_morpholog | 1.58831615 |
| 30 | MP0005377_hearing/vestibular/ear_phenot | 1.54244241 |
| 31 | MP0003878_abnormal_ear_physiology | 1.54244241 |
| 32 | MP0005646_abnormal_pituitary_gland | 1.51807970 |
| 33 | MP0008438_abnormal_cutaneous_collagen | 1.51145139 |
| 34 | MP0001542_abnormal_bone_strength | 1.47693417 |
| 35 | MP0005025_abnormal_response_to | 1.46594882 |
| 36 | MP0006054_spinal_hemorrhage | 1.45833208 |
| 37 | MP0002132_abnormal_respiratory_system | 1.45461688 |
| 38 | MP0008789_abnormal_olfactory_epithelium | 1.45000104 |
| 39 | MP0005000_abnormal_immune_tolerance | 1.44224976 |
| 40 | MP0005083_abnormal_biliary_tract | 1.44100117 |
| 41 | MP0002876_abnormal_thyroid_physiology | 1.43030268 |
| 42 | MP0002638_abnormal_pupillary_reflex | 1.42853581 |
| 43 | MP0000613_abnormal_salivary_gland | 1.42327447 |
| 44 | MP0001905_abnormal_dopamine_level | 1.41183095 |
| 45 | MP0005551_abnormal_eye_electrophysiolog | 1.40296996 |
| 46 | MP0005332_abnormal_amino_acid | 1.39994612 |
| 47 | MP0005174_abnormal_tail_pigmentation | 1.39603394 |
| 48 | MP0002095_abnormal_skin_pigmentation | 1.38069310 |
| 49 | MP0001188_hyperpigmentation | 1.38046550 |
| 50 | MP0008877_abnormal_DNA_methylation | 1.33567789 |
| 51 | MP0004381_abnormal_hair_follicle | 1.32720599 |
| 52 | MP0002160_abnormal_reproductive_system | 1.32621801 |
| 53 | MP0005389_reproductive_system_phenotype | 1.31822200 |
| 54 | MP0003436_decreased_susceptibility_to | 1.31203153 |
| 55 | MP0002693_abnormal_pancreas_physiology | 1.31188939 |
| 56 | MP0002933_joint_inflammation | 1.29526862 |
| 57 | MP0000465_gastrointestinal_hemorrhage | 1.28890018 |
| 58 | MP0002139_abnormal_hepatobiliary_system | 1.28234228 |
| 59 | MP0005410_abnormal_fertilization | 1.27189367 |
| 60 | MP0001835_abnormal_antigen_presentation | 1.25433028 |
| 61 | MP0008007_abnormal_cellular_replicative | 1.25366206 |
| 62 | MP0003763_abnormal_thymus_physiology | 1.25178989 |
| 63 | MP0005360_urolithiasis | 1.24498735 |
| 64 | MP0002653_abnormal_ependyma_morphology | 1.22134864 |
| 65 | MP0005408_hypopigmentation | 1.19683082 |
| 66 | MP0003786_premature_aging | 1.19585550 |
| 67 | MP0003866_abnormal_defecation | 1.17708949 |
| 68 | MP0005409_darkened_coat_color | 1.16074964 |
| 69 | MP0002234_abnormal_pharynx_morphology | 1.15925460 |
| 70 | MP0002736_abnormal_nociception_after | 1.15586927 |
| 71 | MP0010030_abnormal_orbit_morphology | 1.14474578 |
| 72 | MP0005253_abnormal_eye_physiology | 1.14265036 |
| 73 | MP0002277_abnormal_respiratory_mucosa | 1.14094621 |
| 74 | MP0002723_abnormal_immune_serum | 1.13944860 |
| 75 | MP0001944_abnormal_pancreas_morphology | 1.13608331 |
| 76 | MP0002420_abnormal_adaptive_immunity | 1.12756108 |
| 77 | MP0006292_abnormal_olfactory_placode | 1.12591163 |
| 78 | MP0001485_abnormal_pinna_reflex | 1.12220369 |
| 79 | MP0003806_abnormal_nucleotide_metabolis | 1.12041500 |
| 80 | MP0000678_abnormal_parathyroid_gland | 1.11749368 |
| 81 | MP0002396_abnormal_hematopoietic_system | 1.10457628 |
| 82 | MP0001819_abnormal_immune_cell | 1.09134247 |
| 83 | MP0004142_abnormal_muscle_tone | 1.08724527 |
| 84 | MP0006276_abnormal_autonomic_nervous | 1.07949039 |
| 85 | MP0002419_abnormal_innate_immunity | 1.06915009 |
| 86 | MP0005645_abnormal_hypothalamus_physiol | 1.06371282 |
| 87 | MP0001919_abnormal_reproductive_system | 1.05737249 |
| 88 | MP0008004_abnormal_stomach_pH | 1.04559107 |
| 89 | MP0005636_abnormal_mineral_homeostasis | 1.04107779 |
| 90 | MP0009697_abnormal_copulation | 1.04036212 |
| 91 | MP0001663_abnormal_digestive_system | 1.03662937 |
| 92 | MP0000681_abnormal_thyroid_gland | 1.03469451 |
| 93 | MP0000631_abnormal_neuroendocrine_gland | 1.01306502 |
| 94 | MP0008058_abnormal_DNA_repair | 1.01217474 |
| 95 | MP0003077_abnormal_cell_cycle | 1.01069968 |
| 96 | MP0000858_altered_metastatic_potential | 1.00565811 |
| 97 | MP0004019_abnormal_vitamin_homeostasis | 0.99637950 |
| 98 | MP0002138_abnormal_hepatobiliary_system | 0.99375432 |
| 99 | MP0003868_abnormal_feces_composition | 0.98925724 |
| 100 | MP0003646_muscle_fatigue | 0.98846289 |
| 101 | MP0004133_heterotaxia | 0.98574666 |
| 102 | MP0004147_increased_porphyrin_level | 0.97203646 |
| 103 | MP0010155_abnormal_intestine_physiology | 0.96101426 |
| 104 | MP0002452_abnormal_antigen_presenting | 0.95713691 |
| 105 | MP0003959_abnormal_lean_body | 0.94470018 |
| 106 | MP0005381_digestive/alimentary_phenotyp | 0.93725213 |
| 107 | MP0005365_abnormal_bile_salt | 0.93094284 |
| 108 | MP0005503_abnormal_tendon_morphology | 0.92896536 |
| 109 | MP0001845_abnormal_inflammatory_respons | 0.92738771 |
| 110 | MP0001800_abnormal_humoral_immune | 0.92120244 |
| 111 | MP0001533_abnormal_skeleton_physiology | 0.90798836 |
| 112 | MP0000049_abnormal_middle_ear | 0.89776173 |
| 113 | MP0002405_respiratory_system_inflammati | 0.89145264 |
| 114 | MP0001790_abnormal_immune_system | 0.89060346 |
| 115 | MP0005387_immune_system_phenotype | 0.89060346 |
| 116 | MP0001873_stomach_inflammation | 0.88892920 |
| 117 | MP0000358_abnormal_cell_content/ | 0.88878662 |
| 118 | MP0000685_abnormal_immune_system | 0.88870484 |
| 119 | MP0001764_abnormal_homeostasis | 0.87435103 |
| 120 | MP0000716_abnormal_immune_system | 0.86773578 |
| 121 | MP0001968_abnormal_touch/_nociception | 0.86676447 |
| 122 | MP0001666_abnormal_nutrient_absorption | 0.86330791 |
| 123 | MP0002210_abnormal_sex_determination | 0.86150010 |
| 124 | MP0008469_abnormal_protein_level | 0.85412891 |
| 125 | MP0001881_abnormal_mammary_gland | 0.84869886 |
| 126 | MP0004043_abnormal_pH_regulation | 0.84600951 |
| 127 | MP0003111_abnormal_nucleus_morphology | 0.84320944 |
| 128 | MP0001853_heart_inflammation | 0.84054911 |
| 129 | MP0009046_muscle_twitch | 0.83158931 |
| 130 | MP0010094_abnormal_chromosome_stability | 0.83083897 |
| 131 | MP0001664_abnormal_digestion | 0.82718198 |
| 132 | MP0003011_delayed_dark_adaptation | 0.82712504 |
| 133 | MP0002429_abnormal_blood_cell | 0.82417019 |
| 134 | MP0003638_abnormal_response/metabolism_ | 0.81589007 |
| 135 | MP0009764_decreased_sensitivity_to | 0.81481116 |
| 136 | MP0010386_abnormal_urinary_bladder | 0.81474701 |
| 137 | MP0003718_maternal_effect | 0.80940207 |
| 138 | MP0002722_abnormal_immune_system | 0.79666799 |
| 139 | MP0000689_abnormal_spleen_morphology | 0.79310910 |
| 140 | MP0002398_abnormal_bone_marrow | 0.79157035 |
| 141 | MP0000343_altered_response_to | 0.77949525 |
| 142 | MP0006035_abnormal_mitochondrial_morpho | 0.77908407 |
| 143 | MP0005319_abnormal_enzyme/_coenzyme | 0.77052561 |
| 144 | MP0005058_abnormal_lysosome_morphology | 0.76532113 |
| 145 | MP0005085_abnormal_gallbladder_physiolo | 0.75214306 |
| 146 | MP0005670_abnormal_white_adipose | 0.74491036 |
| 147 | MP0004742_abnormal_vestibular_system | 0.74107018 |
| 148 | MP0003137_abnormal_impulse_conducting | 0.74015942 |
| 149 | MP0001929_abnormal_gametogenesis | 0.73489312 |
| 150 | MP0009643_abnormal_urine_homeostasis | 0.72814389 |
| 151 | MP0000653_abnormal_sex_gland | 0.72286888 |
| 152 | MP0001119_abnormal_female_reproductive | 0.69191801 |
| 153 | MP0001145_abnormal_male_reproductive | 0.68854636 |
| 154 | MP0008873_increased_physiological_sensi | 0.68828718 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.75183861 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.47553796 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 5.30550416 |
| 4 | Mitochondrial inheritance (HP:0001427) | 5.23326626 |
| 5 | Reticulocytopenia (HP:0001896) | 5.03956211 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.86108642 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.76248184 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 4.72509421 |
| 9 | Macrocytic anemia (HP:0001972) | 4.64724231 |
| 10 | Progressive macrocephaly (HP:0004481) | 4.47425052 |
| 11 | Acute encephalopathy (HP:0006846) | 4.44752068 |
| 12 | Hepatic necrosis (HP:0002605) | 4.40678268 |
| 13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.33218951 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 4.31614773 |
| 15 | Increased CSF lactate (HP:0002490) | 4.29640566 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 4.24492652 |
| 17 | Type I transferrin isoform profile (HP:0003642) | 4.16312575 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 4.10338800 |
| 19 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.07638292 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.07638292 |
| 21 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 4.02637764 |
| 22 | Exertional dyspnea (HP:0002875) | 3.82236551 |
| 23 | Pallor (HP:0000980) | 3.77292533 |
| 24 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.71386261 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 3.57871918 |
| 26 | Reduced antithrombin III activity (HP:0001976) | 3.51575214 |
| 27 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.37434650 |
| 28 | Abnormal protein glycosylation (HP:0012346) | 3.37434650 |
| 29 | Abnormal glycosylation (HP:0012345) | 3.37434650 |
| 30 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.37434650 |
| 31 | Exercise intolerance (HP:0003546) | 3.24252790 |
| 32 | Increased serum lactate (HP:0002151) | 3.18520786 |
| 33 | Respiratory failure (HP:0002878) | 3.12101313 |
| 34 | Aplastic anemia (HP:0001915) | 3.07339151 |
| 35 | Increased muscle lipid content (HP:0009058) | 3.06041101 |
| 36 | Abnormal hemoglobin (HP:0011902) | 3.00953148 |
| 37 | Lactic acidosis (HP:0003128) | 2.86570347 |
| 38 | Thrombocytosis (HP:0001894) | 2.85769416 |
| 39 | Cerebral edema (HP:0002181) | 2.84832834 |
| 40 | Abnormality of renal resorption (HP:0011038) | 2.83457135 |
| 41 | Respiratory difficulties (HP:0002880) | 2.72191013 |
| 42 | Optic disc pallor (HP:0000543) | 2.65776768 |
| 43 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.63050528 |
| 44 | Microvesicular hepatic steatosis (HP:0001414) | 2.56808799 |
| 45 | Abnormality of midbrain morphology (HP:0002418) | 2.52703819 |
| 46 | Molar tooth sign on MRI (HP:0002419) | 2.52703819 |
| 47 | Vacuolated lymphocytes (HP:0001922) | 2.51466652 |
| 48 | Leukodystrophy (HP:0002415) | 2.51071441 |
| 49 | Pancreatic cysts (HP:0001737) | 2.38914777 |
| 50 | Congenital, generalized hypertrichosis (HP:0004540) | 2.37233598 |
| 51 | Methylmalonic acidemia (HP:0002912) | 2.35290613 |
| 52 | Dicarboxylic aciduria (HP:0003215) | 2.33328314 |
| 53 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.33328314 |
| 54 | Hyperphosphaturia (HP:0003109) | 2.32574518 |
| 55 | Abnormality of urine glucose concentration (HP:0011016) | 2.31855847 |
| 56 | Glycosuria (HP:0003076) | 2.31855847 |
| 57 | Pancreatic fibrosis (HP:0100732) | 2.24145226 |
| 58 | Hypothermia (HP:0002045) | 2.23691193 |
| 59 | Parakeratosis (HP:0001036) | 2.21825117 |
| 60 | Trismus (HP:0000211) | 2.17433018 |
| 61 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.17159665 |
| 62 | Generalized aminoaciduria (HP:0002909) | 2.14518097 |
| 63 | Poor head control (HP:0002421) | 2.13422922 |
| 64 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.11282575 |
| 65 | True hermaphroditism (HP:0010459) | 2.09677196 |
| 66 | Congenital stationary night blindness (HP:0007642) | 2.06929496 |
| 67 | Testicular atrophy (HP:0000029) | 2.05088995 |
| 68 | Hyperglycinemia (HP:0002154) | 2.04869314 |
| 69 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.04626750 |
| 70 | Absent thumb (HP:0009777) | 2.04324425 |
| 71 | Abnormality of glycolysis (HP:0004366) | 2.03445592 |
| 72 | Increased serum pyruvate (HP:0003542) | 2.03445592 |
| 73 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.03421499 |
| 74 | Rough bone trabeculation (HP:0100670) | 2.02897887 |
| 75 | 11 pairs of ribs (HP:0000878) | 2.01231515 |
| 76 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.00887591 |
| 77 | Cerebral hypomyelination (HP:0006808) | 1.97497241 |
| 78 | Oral leukoplakia (HP:0002745) | 1.97378115 |
| 79 | Abnormal pupillary function (HP:0007686) | 1.94390320 |
| 80 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.92949957 |
| 81 | X-linked dominant inheritance (HP:0001423) | 1.92306619 |
| 82 | Amniotic constriction ring (HP:0009775) | 1.90615158 |
| 83 | Abnormality of placental membranes (HP:0011409) | 1.90615158 |
| 84 | CNS demyelination (HP:0007305) | 1.90509319 |
| 85 | Beaking of vertebral bodies (HP:0004568) | 1.89770134 |
| 86 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.88310663 |
| 87 | Pancytopenia (HP:0001876) | 1.86589703 |
| 88 | Progressive microcephaly (HP:0000253) | 1.84750909 |
| 89 | Petechiae (HP:0000967) | 1.84386142 |
| 90 | Sparse eyelashes (HP:0000653) | 1.83119307 |
| 91 | Redundant skin (HP:0001582) | 1.82507104 |
| 92 | IgM deficiency (HP:0002850) | 1.81888569 |
| 93 | Microretrognathia (HP:0000308) | 1.79975608 |
| 94 | Hypoplasia of the pons (HP:0012110) | 1.79951048 |
| 95 | Opisthotonus (HP:0002179) | 1.79019140 |
| 96 | Blindness (HP:0000618) | 1.77068987 |
| 97 | Sclerocornea (HP:0000647) | 1.76206951 |
| 98 | Vomiting (HP:0002013) | 1.75739066 |
| 99 | Depressed nasal ridge (HP:0000457) | 1.75585136 |
| 100 | Abnormal urine phosphate concentration (HP:0012599) | 1.74565574 |
| 101 | Abnormality of secondary sexual hair (HP:0009888) | 1.74014062 |
| 102 | Abnormality of the axillary hair (HP:0100134) | 1.74014062 |
| 103 | Large for gestational age (HP:0001520) | 1.73358229 |
| 104 | Abnormality of the pons (HP:0007361) | 1.71841039 |
| 105 | Emotional lability (HP:0000712) | 1.70662047 |
| 106 | Severe visual impairment (HP:0001141) | 1.70411182 |
| 107 | Nephronophthisis (HP:0000090) | 1.69776540 |
| 108 | Medial flaring of the eyebrow (HP:0010747) | 1.69513079 |
| 109 | Abnormality of alanine metabolism (HP:0010916) | 1.68677660 |
| 110 | Hyperalaninemia (HP:0003348) | 1.68677660 |
| 111 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.68677660 |
| 112 | Cleft eyelid (HP:0000625) | 1.67790152 |
| 113 | Abolished electroretinogram (ERG) (HP:0000550) | 1.65380193 |
| 114 | Rib fusion (HP:0000902) | 1.64275164 |
| 115 | Lethargy (HP:0001254) | 1.62484436 |
| 116 | Hypoplasia of the uterus (HP:0000013) | 1.62157699 |
| 117 | Hypoplasia of the radius (HP:0002984) | 1.60035274 |
| 118 | Delayed CNS myelination (HP:0002188) | 1.59971139 |
| 119 | Neutropenia (HP:0001875) | 1.58557997 |
| 120 | Degeneration of anterior horn cells (HP:0002398) | 1.58492779 |
| 121 | Abnormality of the anterior horn cell (HP:0006802) | 1.58492779 |
| 122 | Secondary amenorrhea (HP:0000869) | 1.57620519 |
| 123 | Progressive muscle weakness (HP:0003323) | 1.56973963 |
| 124 | Type II lissencephaly (HP:0007260) | 1.56509635 |
| 125 | Pendular nystagmus (HP:0012043) | 1.56442143 |
| 126 | Glossoptosis (HP:0000162) | 1.54782770 |
| 127 | Gliosis (HP:0002171) | 1.54528838 |
| 128 | Premature graying of hair (HP:0002216) | 1.54460430 |
| 129 | Renal tubular dysfunction (HP:0000124) | 1.54414222 |
| 130 | Abnormal trabecular bone morphology (HP:0100671) | 1.53739428 |
| 131 | Purpura (HP:0000979) | 1.50118318 |
| 132 | Vertebral compression fractures (HP:0002953) | 1.49768994 |
| 133 | Methylmalonic aciduria (HP:0012120) | 1.48071147 |
| 134 | Progressive neurologic deterioration (HP:0002344) | 1.48024423 |
| 135 | Multiple enchondromatosis (HP:0005701) | 1.47365713 |
| 136 | Dry hair (HP:0011359) | 1.45864798 |
| 137 | Partial duplication of the phalanx of hand (HP:0009999) | 1.44797750 |
| 138 | Congenital sensorineural hearing impairment (HP:0008527) | 1.43859604 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.65956195 |
| 2 | NME2 | 5.16640874 |
| 3 | STK16 | 4.14731790 |
| 4 | BUB1 | 3.09151868 |
| 5 | EIF2AK3 | 3.06032704 |
| 6 | EIF2AK1 | 2.92825608 |
| 7 | PIM2 | 2.75174836 |
| 8 | TLK1 | 2.71728275 |
| 9 | NME1 | 2.54534025 |
| 10 | VRK1 | 2.45297835 |
| 11 | TESK2 | 2.35585593 |
| 12 | NUAK1 | 2.16990878 |
| 13 | MST4 | 2.10222742 |
| 14 | IRAK3 | 2.03821528 |
| 15 | MAP4K2 | 1.99459531 |
| 16 | PBK | 1.98746292 |
| 17 | WEE1 | 1.89584184 |
| 18 | IRAK4 | 1.87196720 |
| 19 | BCKDK | 1.85540579 |
| 20 | TEC | 1.73500141 |
| 21 | CDC7 | 1.62987425 |
| 22 | GRK1 | 1.59419880 |
| 23 | LIMK1 | 1.57602965 |
| 24 | PASK | 1.47682652 |
| 25 | KDR | 1.47578203 |
| 26 | PDK2 | 1.45486326 |
| 27 | WNK3 | 1.40521221 |
| 28 | INSRR | 1.37069396 |
| 29 | MAPK15 | 1.34803468 |
| 30 | SRPK1 | 1.33486824 |
| 31 | CDK8 | 1.32475922 |
| 32 | CDK19 | 1.32427585 |
| 33 | MAP2K6 | 1.27942791 |
| 34 | BMPR1B | 1.24573406 |
| 35 | ADRBK2 | 1.14647367 |
| 36 | FRK | 1.13412258 |
| 37 | STK39 | 1.12726324 |
| 38 | MYLK | 1.12474077 |
| 39 | BLK | 1.12454865 |
| 40 | MAPKAPK3 | 1.09016531 |
| 41 | IRAK1 | 1.05251822 |
| 42 | TNIK | 1.04731357 |
| 43 | ARAF | 1.04500614 |
| 44 | MAP3K12 | 1.04213562 |
| 45 | MAPKAPK5 | 1.01763836 |
| 46 | MKNK1 | 1.01449553 |
| 47 | NLK | 0.94077283 |
| 48 | NEK1 | 0.93749477 |
| 49 | FES | 0.93681801 |
| 50 | ABL2 | 0.91809069 |
| 51 | PIK3CG | 0.91714107 |
| 52 | MUSK | 0.91628748 |
| 53 | MKNK2 | 0.91146305 |
| 54 | TESK1 | 0.89952527 |
| 55 | RPS6KB2 | 0.89725937 |
| 56 | EIF2AK2 | 0.86477489 |
| 57 | BTK | 0.85803360 |
| 58 | BRAF | 0.83595562 |
| 59 | DYRK2 | 0.82818824 |
| 60 | PLK4 | 0.82588602 |
| 61 | IRAK2 | 0.82424045 |
| 62 | TXK | 0.81522378 |
| 63 | ILK | 0.80075769 |
| 64 | GRK5 | 0.79761556 |
| 65 | ERN1 | 0.79084542 |
| 66 | DYRK3 | 0.78540420 |
| 67 | FLT3 | 0.78489518 |
| 68 | ZAP70 | 0.76678737 |
| 69 | PLK3 | 0.74988400 |
| 70 | AURKA | 0.74454992 |
| 71 | PINK1 | 0.74129818 |
| 72 | GRK7 | 0.73452494 |
| 73 | MAP2K2 | 0.72845196 |
| 74 | TAOK3 | 0.72712152 |
| 75 | CHEK2 | 0.72372409 |
| 76 | CSNK1G1 | 0.70475179 |
| 77 | PRKCI | 0.69298079 |
| 78 | TGFBR1 | 0.68590083 |
| 79 | SCYL2 | 0.67606817 |
| 80 | DAPK1 | 0.66558989 |
| 81 | RPS6KA5 | 0.66378406 |
| 82 | CSNK1G2 | 0.66246775 |
| 83 | NEK9 | 0.65696370 |
| 84 | ACVR1B | 0.65417853 |
| 85 | LYN | 0.64018671 |
| 86 | MAP4K1 | 0.63559362 |
| 87 | CDK7 | 0.62973642 |
| 88 | CSNK2A1 | 0.62674268 |
| 89 | BRSK2 | 0.61654828 |
| 90 | ATR | 0.60594963 |
| 91 | TBK1 | 0.60269820 |
| 92 | AURKB | 0.60254044 |
| 93 | WNK4 | 0.59657570 |
| 94 | MAP3K11 | 0.59493922 |
| 95 | TSSK6 | 0.58922672 |
| 96 | CASK | 0.58168927 |
| 97 | KIT | 0.58126718 |
| 98 | TAF1 | 0.58042864 |
| 99 | CSNK1A1L | 0.57666301 |
| 100 | PAK1 | 0.56965619 |
| 101 | CSNK2A2 | 0.55741923 |
| 102 | DAPK3 | 0.54978175 |
| 103 | BRSK1 | 0.54502023 |
| 104 | UHMK1 | 0.53457079 |
| 105 | OXSR1 | 0.52324205 |
| 106 | MAP2K7 | 0.52247818 |
| 107 | TRIM28 | 0.51900296 |
| 108 | CSNK1G3 | 0.51093824 |
| 109 | ADRBK1 | 0.50487264 |
| 110 | PRKCG | 0.49603741 |
| 111 | CLK1 | 0.49590306 |
| 112 | LCK | 0.48905414 |
| 113 | IKBKB | 0.47613092 |
| 114 | YES1 | 0.47516493 |
| 115 | HIPK2 | 0.47410926 |
| 116 | TIE1 | 0.46140462 |
| 117 | PRKG2 | 0.45652370 |
| 118 | CCNB1 | 0.45193709 |
| 119 | CAMK2D | 0.44987703 |
| 120 | LRRK2 | 0.44863267 |
| 121 | STK4 | 0.43157291 |
| 122 | TAOK2 | 0.41755820 |
| 123 | CSNK1A1 | 0.41567522 |
| 124 | MOS | 0.40888739 |
| 125 | TNK2 | 0.40583096 |
| 126 | PLK1 | 0.40562467 |
| 127 | MARK3 | 0.39479904 |
| 128 | SYK | 0.38945624 |
| 129 | TTK | 0.38145001 |
| 130 | EPHB2 | 0.37507817 |
| 131 | PIK3CA | 0.37190453 |
| 132 | MAPK4 | 0.36348417 |
| 133 | PIM1 | 0.36130559 |
| 134 | IKBKE | 0.35994419 |
| 135 | PRKACA | 0.35392363 |
| 136 | GRK6 | 0.34795602 |
| 137 | CAMK2B | 0.34732603 |
| 138 | ZAK | 0.34496768 |
| 139 | PRKCQ | 0.32840399 |
| 140 | PRKCA | 0.30301602 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 6.14232132 |
| 2 | Protein export_Homo sapiens_hsa03060 | 5.35699589 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.92835511 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.67575164 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.43154181 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.11326540 |
| 7 | DNA replication_Homo sapiens_hsa03030 | 2.55272935 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.45749098 |
| 9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.44543061 |
| 10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.28125562 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.18685548 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.00019996 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 1.89378839 |
| 14 | Spliceosome_Homo sapiens_hsa03040 | 1.81537951 |
| 15 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.79007024 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.68518920 |
| 17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.63792663 |
| 18 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.50955332 |
| 19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.47406682 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.47073665 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.46380590 |
| 22 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.43722762 |
| 23 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.36001444 |
| 24 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.30283303 |
| 25 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.22626603 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.20496032 |
| 27 | Sulfur relay system_Homo sapiens_hsa04122 | 1.20086268 |
| 28 | Basal transcription factors_Homo sapiens_hsa03022 | 1.17950500 |
| 29 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.16277290 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.12801580 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.12498513 |
| 32 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.07451826 |
| 33 | Other glycan degradation_Homo sapiens_hsa00511 | 1.05473197 |
| 34 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.00328477 |
| 35 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.99863582 |
| 36 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.98222528 |
| 37 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.97670789 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.96938153 |
| 39 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.96574684 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 0.94587100 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.93757109 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 0.89243827 |
| 43 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.86043870 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.84146096 |
| 45 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.82817557 |
| 46 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.82606244 |
| 47 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.82117581 |
| 48 | Phototransduction_Homo sapiens_hsa04744 | 0.80328618 |
| 49 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.79807950 |
| 50 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.77667700 |
| 51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74982075 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74462724 |
| 53 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.71319341 |
| 54 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.69015407 |
| 55 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.67462763 |
| 56 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.66872503 |
| 57 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.66205797 |
| 58 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64692401 |
| 59 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.64196860 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.64155266 |
| 61 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.63887538 |
| 62 | Retinol metabolism_Homo sapiens_hsa00830 | 0.63528025 |
| 63 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.59966701 |
| 64 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.58443007 |
| 65 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.55073047 |
| 66 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.52747096 |
| 67 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.52019357 |
| 68 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.51411225 |
| 69 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.49508258 |
| 70 | Allograft rejection_Homo sapiens_hsa05330 | 0.49209186 |
| 71 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48545216 |
| 72 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.46503243 |
| 73 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.46365494 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.45691402 |
| 75 | Asthma_Homo sapiens_hsa05310 | 0.45669975 |
| 76 | Galactose metabolism_Homo sapiens_hsa00052 | 0.45183311 |
| 77 | Cell cycle_Homo sapiens_hsa04110 | 0.44759733 |
| 78 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.44481932 |
| 79 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.43088328 |
| 80 | Malaria_Homo sapiens_hsa05144 | 0.41821973 |
| 81 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41495192 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.41184811 |
| 83 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.41134692 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.41107857 |
| 85 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.40974772 |
| 86 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.40921373 |
| 87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.40870760 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.39566035 |
| 89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.38103441 |
| 90 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.37545606 |
| 91 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.37494623 |
| 92 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.37032776 |
| 93 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36375797 |
| 94 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.35990142 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.35515615 |
| 96 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.34126176 |
| 97 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.34056497 |
| 98 | Histidine metabolism_Homo sapiens_hsa00340 | 0.33679935 |
| 99 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.33366033 |
| 100 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.32588565 |
| 101 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.32519763 |
| 102 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.32446884 |
| 103 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31531554 |
| 104 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.31438588 |
| 105 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.31099601 |
| 106 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.30692521 |
| 107 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.29290868 |
| 108 | Carbon metabolism_Homo sapiens_hsa01200 | 0.28588249 |
| 109 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28472361 |
| 110 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.28353972 |
| 111 | Pertussis_Homo sapiens_hsa05133 | 0.27165058 |
| 112 | Mineral absorption_Homo sapiens_hsa04978 | 0.26884102 |
| 113 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.26349370 |
| 114 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.25810252 |
| 115 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.25014751 |
| 116 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.24982428 |
| 117 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.24385305 |
| 118 | Phagosome_Homo sapiens_hsa04145 | 0.24221269 |
| 119 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.22716305 |
| 120 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.20868360 |
| 121 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.20252257 |
| 122 | Lysosome_Homo sapiens_hsa04142 | 0.19291568 |
| 123 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.18076477 |
| 124 | Peroxisome_Homo sapiens_hsa04146 | 0.17874678 |
| 125 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.14801292 |
| 126 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.14083782 |
| 127 | Measles_Homo sapiens_hsa05162 | 0.13540150 |
| 128 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.13342130 |
| 129 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.13137490 |

