KSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.94867810
2positive regulation of gamma-delta T cell activation (GO:0046645)4.92606994
3locomotory exploration behavior (GO:0035641)4.45801146
4positive regulation by symbiont of host defense response (GO:0052509)4.33156790
5modulation by symbiont of host defense response (GO:0052031)4.33156790
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33156790
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33156790
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.33156790
9modulation by symbiont of host immune response (GO:0052553)4.33156790
10synaptic vesicle maturation (GO:0016188)4.30127637
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29218050
12vocalization behavior (GO:0071625)4.20199087
13sarcoplasmic reticulum calcium ion transport (GO:0070296)4.17400317
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12504106
15regulation of gamma-delta T cell activation (GO:0046643)4.12060614
16neuronal action potential propagation (GO:0019227)3.94102719
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87566568
18sodium ion export (GO:0071436)3.84156303
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81280835
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.77727873
21skeletal muscle contraction (GO:0003009)3.77534640
22antigen processing and presentation of endogenous antigen (GO:0019883)3.73724817
23regulation of glutamate receptor signaling pathway (GO:1900449)3.73340883
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72329882
25regulation of B cell receptor signaling pathway (GO:0050855)3.71218248
26cellular potassium ion homeostasis (GO:0030007)3.69320263
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67837396
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.66643400
29response to muramyl dipeptide (GO:0032495)3.65940990
30muscle filament sliding (GO:0030049)3.64980530
31actin-myosin filament sliding (GO:0033275)3.64980530
32regulation of gamma-delta T cell differentiation (GO:0045586)3.63536737
33skeletal muscle adaptation (GO:0043501)3.54793305
34plasma membrane repair (GO:0001778)3.52960955
35regulation of synapse structural plasticity (GO:0051823)3.49628279
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.48682361
37glutamate secretion (GO:0014047)3.46247704
38synaptic vesicle exocytosis (GO:0016079)3.45659322
39detection of other organism (GO:0098543)3.44538275
40regulation of neuronal synaptic plasticity (GO:0048168)3.44508452
41skeletal muscle fiber development (GO:0048741)3.44508410
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43128053
43germinal center formation (GO:0002467)3.42716041
44regulation of skeletal muscle contraction (GO:0014819)3.42437571
45protein localization to synapse (GO:0035418)3.39585132
46B cell receptor signaling pathway (GO:0050853)3.39540533
47detection of bacterium (GO:0016045)3.38297286
48response to interleukin-15 (GO:0070672)3.38172032
49regulation of dendritic spine morphogenesis (GO:0061001)3.35483227
50regulation of long-term neuronal synaptic plasticity (GO:0048169)3.34992175
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34618231
52exploration behavior (GO:0035640)3.33494268
53glutamate receptor signaling pathway (GO:0007215)3.30579782
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.29897985
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.25721151
56histone H3-K9 demethylation (GO:0033169)3.24740143
57histone H3-K36 demethylation (GO:0070544)3.20723398
58mannose metabolic process (GO:0006013)3.18315284
59layer formation in cerebral cortex (GO:0021819)3.17381990
60nerve growth factor signaling pathway (GO:0038180)3.13202868
61negative regulation of cell killing (GO:0031342)3.12244112
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12244112
63proline transport (GO:0015824)3.10900469
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.06770315
65positive regulation of synapse maturation (GO:0090129)3.06029362
66macrophage activation involved in immune response (GO:0002281)3.05133058
67negative thymic T cell selection (GO:0045060)3.04509967
68regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04228746
69regulation of ARF protein signal transduction (GO:0032012)3.03969615
70signal complex assembly (GO:0007172)3.03872049
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03137073
72long-term memory (GO:0007616)3.01664745
73dendritic spine morphogenesis (GO:0060997)2.97777352
74histone lysine demethylation (GO:0070076)2.93804963
75positive thymic T cell selection (GO:0045059)2.93749950
76histone H3-K4 trimethylation (GO:0080182)2.92725801
77regulation of synaptic vesicle exocytosis (GO:2000300)2.92408531
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.92382330
79actin-mediated cell contraction (GO:0070252)2.92285489
80negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91788805
81potassium ion import (GO:0010107)2.91175664
82synaptic transmission, glutamatergic (GO:0035249)2.90646521
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.89908181
84thymic T cell selection (GO:0045061)2.89784577
85cellular extravasation (GO:0045123)2.89110926
86membrane depolarization during action potential (GO:0086010)2.89066007
87detection of external biotic stimulus (GO:0098581)2.89036911
88regulation of calcium ion transmembrane transporter activity (GO:1901019)2.88526178
89regulation of calcium ion transmembrane transport (GO:1903169)2.88526178
90cellular response to interleukin-15 (GO:0071350)2.88410402
91regulation of dendritic spine development (GO:0060998)2.87146287
92regulation of synaptic plasticity (GO:0048167)2.86928840
93detection of molecule of bacterial origin (GO:0032490)2.85480107
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85302308
95striated muscle contraction (GO:0006941)2.85034553
96response to histamine (GO:0034776)2.84017180
97negative regulation of lymphocyte mediated immunity (GO:0002707)2.82541430
98myotube cell development (GO:0014904)2.82410244
99regulation of histone H3-K27 methylation (GO:0061085)2.82027840
100activation of protein kinase A activity (GO:0034199)2.81745376
101histone demethylation (GO:0016577)2.80859555
102negative T cell selection (GO:0043383)2.80125723
103regulation of ARF GTPase activity (GO:0032312)2.79836427
104response to peptidoglycan (GO:0032494)2.79112642
105regulation of synaptic vesicle transport (GO:1902803)2.79084720
106positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79060165
107tolerance induction (GO:0002507)2.78923541
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76581573
109response to host (GO:0075136)2.76581573
110response to host defenses (GO:0052200)2.76581573
111response to host immune response (GO:0052572)2.75457821
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75457821
113positive regulation of Rap GTPase activity (GO:0032854)2.74981944
114regulation of cell communication by electrical coupling (GO:0010649)2.74081442
115cell communication by electrical coupling (GO:0010644)2.73733074
116detection of biotic stimulus (GO:0009595)2.69283383
117positive regulation of fibroblast migration (GO:0010763)2.69043277
118CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.68257367
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.67641406
120regulation of postsynaptic membrane potential (GO:0060078)2.66869853
121regulation of interleukin-12 biosynthetic process (GO:0045075)2.65124378
122neuromuscular process controlling balance (GO:0050885)2.65108004
123synaptic vesicle endocytosis (GO:0048488)2.64396143
124regulation of Rap GTPase activity (GO:0032317)2.63732080
125positive regulation of dendritic spine development (GO:0060999)2.63072274
126neuron recognition (GO:0008038)2.62963777
127negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62945782
128cellular response to electrical stimulus (GO:0071257)2.61728581
129neuron-neuron synaptic transmission (GO:0007270)2.61330605
130cellular sodium ion homeostasis (GO:0006883)2.60997593
131T cell selection (GO:0045058)2.60917927
132dendritic spine organization (GO:0097061)2.60418216
133creatine metabolic process (GO:0006600)2.60325851
134chemosensory behavior (GO:0007635)2.59852698
135stress fiber assembly (GO:0043149)2.59749000
136positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58748215
137actin filament-based movement (GO:0030048)2.58603184
138negative regulation of toll-like receptor signaling pathway (GO:0034122)2.58467116
139positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57846140
140positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57341956
141antigen processing and presentation via MHC class Ib (GO:0002475)2.57214377
142negative regulation of myotube differentiation (GO:0010832)2.56990091
143negative regulation of leukocyte mediated immunity (GO:0002704)2.56259422
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56234958
145regulation of ion transmembrane transporter activity (GO:0032412)2.55074043
146vesicle transport along microtubule (GO:0047496)2.54377248
147neuromuscular synaptic transmission (GO:0007274)2.54062489
148regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.53844026
149regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53574176
150leukocyte aggregation (GO:0070486)2.52866486
151L-amino acid import (GO:0043092)2.52438529
152behavioral defense response (GO:0002209)2.51989356
153behavioral fear response (GO:0001662)2.51989356
154regulation of mast cell degranulation (GO:0043304)2.51605695
155positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51580996
156negative regulation of T cell mediated immunity (GO:0002710)2.51133856
157positive regulation of membrane potential (GO:0045838)2.50895884
158membrane depolarization (GO:0051899)2.50470842
159neurotransmitter secretion (GO:0007269)2.50210701
160positive regulation of dendritic spine morphogenesis (GO:0061003)2.49358650
161peptidyl-threonine phosphorylation (GO:0018107)2.48802442
162negative regulation of histone methylation (GO:0031061)2.48584299
163axonal fasciculation (GO:0007413)2.47911686
164neurotransmitter-gated ion channel clustering (GO:0072578)2.46815647
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.44273159
166intracellular estrogen receptor signaling pathway (GO:0030520)2.43513790
1673-UTR-mediated mRNA stabilization (GO:0070935)2.42109088
168positive T cell selection (GO:0043368)2.41225750
169macrophage activation (GO:0042116)2.40678727
170positive regulation of cellular amide metabolic process (GO:0034250)2.39380146
171regulation of NFAT protein import into nucleus (GO:0051532)2.39278574
172positive regulation of B cell differentiation (GO:0045579)2.38762708
173response to laminar fluid shear stress (GO:0034616)2.38213464
174protein dealkylation (GO:0008214)2.38141263
175protein demethylation (GO:0006482)2.38141263
176regulation of leukocyte degranulation (GO:0043300)2.37849706
177positive regulation of myotube differentiation (GO:0010831)2.35315281
178modulation by virus of host process (GO:0019054)2.34674041
179regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33712771
180B cell homeostasis (GO:0001782)2.33361744
181regulation of mast cell activation involved in immune response (GO:0033006)2.33163246
182regulation of interferon-beta biosynthetic process (GO:0045357)2.33001491
183positive regulation of CREB transcription factor activity (GO:0032793)2.30095093
184modulation by symbiont of host cellular process (GO:0044068)2.27921477
185megakaryocyte development (GO:0035855)2.27697848
186positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.25997666
187regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.25620136
188regulation of T-helper 2 cell differentiation (GO:0045628)2.22855093
189T-helper 1 type immune response (GO:0042088)2.22441084
190regulation of RNA export from nucleus (GO:0046831)2.20976818
191regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.20493370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47891746
2* DROSHA_22980978_ChIP-Seq_HELA_Human2.67679415
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.64409753
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.63844872
5VDR_21846776_ChIP-Seq_THP-1_Human2.54907140
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38743613
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35070786
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27842219
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25568744
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23470249
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23470249
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20912934
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10164147
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07024600
15SCL_19346495_ChIP-Seq_HPC-7_Human2.06909517
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.06214039
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04204126
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03261878
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02298666
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00963269
21* MAF_26560356_Chip-Seq_TH1_Human1.94113681
22AR_21572438_ChIP-Seq_LNCaP_Human1.91637342
23* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90865748
24VDR_24763502_ChIP-Seq_THP-1_Human1.90844146
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90529235
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88056156
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87876437
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.83874812
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82205379
30KDM2B_26808549_Chip-Seq_K562_Human1.81653385
31* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79512444
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.79337636
33GBX2_23144817_ChIP-Seq_PC3_Human1.78889591
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78047020
35* KDM2B_26808549_Chip-Seq_DND41_Human1.76771725
36REST_21632747_ChIP-Seq_MESCs_Mouse1.75760212
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74799655
38* GATA1_19941827_ChIP-Seq_MEL_Mouse1.74174679
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73358860
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66745543
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65417252
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64734415
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63805527
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63254596
45* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61823378
46* UTX_26944678_Chip-Seq_JUKART_Human1.59896457
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.59479759
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58245866
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.57701929
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54840321
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52326124
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.48882090
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.47881277
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.46662915
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45969186
56* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45488171
57* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44198943
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39694329
59GATA1_22025678_ChIP-Seq_K562_Human1.38465185
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38311584
61MAF_26560356_Chip-Seq_TH2_Human1.36804355
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.36478811
63NCOR1_26117541_ChIP-Seq_K562_Human1.34400358
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34302601
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.33288396
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31621701
67NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31501119
68* IRF8_27001747_Chip-Seq_BMDM_Mouse1.31026250
69* GATA2_19941826_ChIP-Seq_K562_Human1.30166244
70* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28783942
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.28122038
72* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26732998
73TCF7_22412390_ChIP-Seq_EML_Mouse1.26731873
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26297406
75* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25991333
76* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25827638
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.25433906
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24994465
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.24873001
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24585802
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22420977
82* LXR_22292898_ChIP-Seq_THP-1_Human1.22218243
83* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21156734
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21066231
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20339895
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.18632395
87TP53_16413492_ChIP-PET_HCT116_Human1.18051401
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17268882
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16997019
90CTCF_27219007_Chip-Seq_Bcells_Human1.12042556
91* MYB_26560356_Chip-Seq_TH1_Human1.10838922
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10696292
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10696292
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10696292
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.10119344
96* AR_19668381_ChIP-Seq_PC3_Human1.09461941
97MYB_26560356_Chip-Seq_TH2_Human1.09331195
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08753906
99* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08653162
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07894245
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07017458
102* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06471577
103VDR_24787735_ChIP-Seq_THP-1_Human1.04916850
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03997896
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02892222
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02685537
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.02652268
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01456509
109* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00544026
110* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98060502
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97523763
112RXR_22108803_ChIP-Seq_LS180_Human0.97146110
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97108565
114CREB1_26743006_Chip-Seq_LNCaP_Human0.97107475
115* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96146963
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95611880
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.95109091
118* SMAD4_21799915_ChIP-Seq_A2780_Human0.94735123
119* SPI1_23127762_ChIP-Seq_K562_Human0.94099000
120ZNF274_21170338_ChIP-Seq_K562_Hela0.93659507
121P68_20966046_ChIP-Seq_HELA_Human0.93655514
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91556527
123ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91001344
124* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90704668
125OCT4_19829295_ChIP-Seq_ESCs_Human0.90687998
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90180158
127GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89847580
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.89757046
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89522399
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89514984
131* GATA1_19941826_ChIP-Seq_K562_Human0.88926843
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88903264
133IRF8_21731497_ChIP-ChIP_J774_Mouse0.88749349
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88483907
135RACK7_27058665_Chip-Seq_MCF-7_Human0.87921110
136MYC_22102868_ChIP-Seq_BL_Human0.86940919
137SMC4_20622854_ChIP-Seq_HELA_Human0.86661010
138* ARNT_22903824_ChIP-Seq_MCF-7_Human0.86650863
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.86482429
140* AHR_22903824_ChIP-Seq_MCF-7_Human0.86131713
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85981276
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85825824
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.85636138
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85176007
145RUNX_20019798_ChIP-Seq_JUKART_Human0.84921516
146* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84811531
147GATA3_27048872_Chip-Seq_THYMUS_Human0.84138185
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.83095947
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.83095947
150* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82862626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0004859_abnormal_synaptic_plasticity6.29677533
2MP0004145_abnormal_muscle_electrophysio3.98994331
3MP0004270_analgesia3.69836523
4MP0000751_myopathy3.67939650
5MP0003880_abnormal_central_pattern3.25493348
6* MP0003635_abnormal_synaptic_transmissio3.23093166
7MP0000749_muscle_degeneration2.92382481
8MP0001835_abnormal_antigen_presentation2.86061856
9MP0005451_abnormal_body_composition2.81459609
10* MP0003436_decreased_susceptibility_to2.74072400
11MP0000685_abnormal_immune_system2.71891194
12MP0009278_abnormal_bone_marrow2.64166381
13MP0003646_muscle_fatigue2.60193027
14* MP0002063_abnormal_learning/memory/cond2.51419053
15MP0004510_myositis2.47681022
16MP0000747_muscle_weakness2.45943648
17MP0009745_abnormal_behavioral_response2.44295176
18MP0005387_immune_system_phenotype2.39325018
19MP0001790_abnormal_immune_system2.39325018
20MP0003724_increased_susceptibility_to2.37757488
21MP0003878_abnormal_ear_physiology2.25731691
22MP0005377_hearing/vestibular/ear_phenot2.25731691
23MP0002837_dystrophic_cardiac_calcinosis2.23203697
24MP0002106_abnormal_muscle_physiology2.22675964
25MP0005671_abnormal_response_to2.21549852
26MP0001800_abnormal_humoral_immune2.19916370
27MP0002064_seizures2.19685037
28MP0001501_abnormal_sleep_pattern2.08248358
29MP0003763_abnormal_thymus_physiology2.04791910
30MP0002822_catalepsy2.02874110
31MP0004036_abnormal_muscle_relaxation2.02652376
32MP0000759_abnormal_skeletal_muscle2.00776030
33MP0002419_abnormal_innate_immunity1.99606970
34MP0004858_abnormal_nervous_system1.98470099
35MP0002396_abnormal_hematopoietic_system1.98301943
36MP0004130_abnormal_muscle_cell1.95320908
37MP0004087_abnormal_muscle_fiber1.93219302
38* MP0005000_abnormal_immune_tolerance1.92583117
39MP0003329_amyloid_beta_deposits1.88796338
40MP0008569_lethality_at_weaning1.83934645
41MP0005025_abnormal_response_to1.83241183
42MP0005369_muscle_phenotype1.82688899
43MP0002572_abnormal_emotion/affect_behav1.80095021
44MP0005620_abnormal_muscle_contractility1.77428556
45* MP0002420_abnormal_adaptive_immunity1.75439933
46MP0002272_abnormal_nervous_system1.75164573
47* MP0001819_abnormal_immune_cell1.72862375
48MP0003828_pulmonary_edema1.72743540
49* MP0002723_abnormal_immune_serum1.72107157
50* MP0005076_abnormal_cell_differentiation1.70166986
51* MP0002398_abnormal_bone_marrow1.67946936
52MP0009780_abnormal_chondrocyte_physiolo1.67745936
53MP0008961_abnormal_basal_metabolism1.67565263
54MP0002269_muscular_atrophy1.66941266
55MP0001486_abnormal_startle_reflex1.66786147
56MP0004233_abnormal_muscle_weight1.66403277
57MP0004185_abnormal_adipocyte_glucose1.62749346
58MP0002452_abnormal_antigen_presenting1.61806086
59MP0001440_abnormal_grooming_behavior1.61794479
60MP0002405_respiratory_system_inflammati1.57289569
61MP0004947_skin_inflammation1.54358048
62MP0002734_abnormal_mechanical_nocicepti1.53917417
63MP0000703_abnormal_thymus_morphology1.49472060
64MP0004484_altered_response_of1.45975707
65MP0009046_muscle_twitch1.45388478
66MP0003879_abnormal_hair_cell1.44951485
67MP0001545_abnormal_hematopoietic_system1.44784632
68MP0005397_hematopoietic_system_phenotyp1.44784632
69MP0001958_emphysema1.44671931
70* MP0000716_abnormal_immune_system1.42800303
71MP0003172_abnormal_lysosome_physiology1.41473819
72MP0000733_abnormal_muscle_development1.38158106
73MP0003075_altered_response_to1.35946491
74MP0001968_abnormal_touch/_nociception1.35875256
75MP0010155_abnormal_intestine_physiology1.34935882
76MP0002722_abnormal_immune_system1.34534143
77MP0005423_abnormal_somatic_nervous1.31383994
78MP0002998_abnormal_bone_remodeling1.31088396
79MP0004885_abnormal_endolymph1.31074722
80MP0009333_abnormal_splenocyte_physiolog1.30788161
81MP0004808_abnormal_hematopoietic_stem1.30084973
82MP0002254_reproductive_system_inflammat1.29449423
83MP0004811_abnormal_neuron_physiology1.28991545
84MP0002735_abnormal_chemical_nociception1.28574675
85MP0008260_abnormal_autophagy1.28362058
86MP0010234_abnormal_vibrissa_follicle1.27031201
87MP0003045_fibrosis1.25177671
88MP0000750_abnormal_muscle_regeneration1.24698060
89MP0002249_abnormal_larynx_morphology1.24236837
90MP0003690_abnormal_glial_cell1.18943481
91MP0002909_abnormal_adrenal_gland1.16574546
92* MP0002429_abnormal_blood_cell1.16541897
93MP0005464_abnormal_platelet_physiology1.16258547
94MP0002733_abnormal_thermal_nociception1.12908438
95MP0000689_abnormal_spleen_morphology1.12570964
96MP0004215_abnormal_myocardial_fiber1.12557976
97MP0005409_darkened_coat_color1.12172108
98MP0001970_abnormal_pain_threshold1.12130818
99MP0002132_abnormal_respiratory_system1.11264187
100MP0003303_peritoneal_inflammation1.10462334
101MP0005330_cardiomyopathy1.10186865
102MP0002067_abnormal_sensory_capabilities1.08866672
103MP0000604_amyloidosis1.08497850
104MP0009785_altered_susceptibility_to1.07059368
105MP0002653_abnormal_ependyma_morphology1.06030298
106MP0003633_abnormal_nervous_system1.06018869
107MP0001348_abnormal_lacrimal_gland1.05210074
108MP0000013_abnormal_adipose_tissue1.05003320
109MP0002066_abnormal_motor_capabilities/c1.04287610
110MP0002108_abnormal_muscle_morphology1.03979751
111MP0003183_abnormal_peptide_metabolism1.03852767
112MP0004264_abnormal_extraembryonic_tissu1.03276470
113MP0005623_abnormal_meninges_morphology1.02151878
114MP0003866_abnormal_defecation1.01444904
115MP0002736_abnormal_nociception_after0.98692699
116MP0008874_decreased_physiological_sensi0.98139543
117MP0005375_adipose_tissue_phenotype0.97615612
118MP0000955_abnormal_spinal_cord0.97103650
119MP0005167_abnormal_blood-brain_barrier0.96805729
120MP0003656_abnormal_erythrocyte_physiolo0.96427505
121MP0002184_abnormal_innervation0.96200443
122MP0005666_abnormal_adipose_tissue0.96195940
123MP0000778_abnormal_nervous_system0.94024135
124MP0003787_abnormal_imprinting0.91154598
125MP0002882_abnormal_neuron_morphology0.90279589
126MP0003300_gastrointestinal_ulcer0.89938521
127MP0005083_abnormal_biliary_tract0.89569048
128* MP0001533_abnormal_skeleton_physiology0.89324092
129MP0004084_abnormal_cardiac_muscle0.88531760
130MP0005386_behavior/neurological_phenoty0.88402447
131MP0004924_abnormal_behavior0.88402447
132MP0003566_abnormal_cell_adhesion0.87096856
133MP0003705_abnormal_hypodermis_morpholog0.86936016
134MP0004782_abnormal_surfactant_physiolog0.86747861
135MP0000003_abnormal_adipose_tissue0.85777038
136MP0002166_altered_tumor_susceptibility0.84324699
137MP0002133_abnormal_respiratory_system0.84249663
138MP0005388_respiratory_system_phenotype0.84249663
139MP0000920_abnormal_myelination0.83740417
140MP0000678_abnormal_parathyroid_gland0.81995673
141MP0002557_abnormal_social/conspecific_i0.81332397
142MP0003631_nervous_system_phenotype0.80566211
143MP0002138_abnormal_hepatobiliary_system0.78737612
144MP0000465_gastrointestinal_hemorrhage0.78645685
145MP0001851_eye_inflammation0.76528397
146MP0005310_abnormal_salivary_gland0.75470312
147MP0005166_decreased_susceptibility_to0.75204113
148* MP0009115_abnormal_fat_cell0.74554310
149MP0002972_abnormal_cardiac_muscle0.73193559
150MP0002148_abnormal_hypersensitivity_rea0.73045120
151MP0002009_preneoplasia0.72920609
152MP0004085_abnormal_heartbeat0.72629216
153MP0001845_abnormal_inflammatory_respons0.72627990
154MP0001873_stomach_inflammation0.70707377
155MP0002089_abnormal_postnatal_growth/wei0.70289630
156MP0001849_ear_inflammation0.67700315
157MP0002971_abnormal_brown_adipose0.66648926
158MP0008770_decreased_survivor_rate0.64213544
159MP0010630_abnormal_cardiac_muscle0.63611799
160MP0003137_abnormal_impulse_conducting0.63564128
161MP0002152_abnormal_brain_morphology0.62884138
162MP0002332_abnormal_exercise_endurance0.62617642
163MP0003091_abnormal_cell_migration0.60135526
164MP0002234_abnormal_pharynx_morphology0.59546853
165MP0001299_abnormal_eye_distance/0.59041047
166MP0002069_abnormal_eating/drinking_beha0.58604604

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.00271274
2Muscle fiber inclusion bodies (HP:0100299)5.78411444
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.56249805
4Nemaline bodies (HP:0003798)5.16382261
5Type 1 muscle fiber predominance (HP:0003803)5.11691488
6Exercise-induced muscle cramps (HP:0003710)4.87624730
7Focal motor seizures (HP:0011153)4.66346014
8Difficulty running (HP:0009046)4.49919563
9Muscle hypertrophy of the lower extremities (HP:0008968)4.43049881
10Myopathic facies (HP:0002058)4.28086122
11Distal arthrogryposis (HP:0005684)4.26280257
12Round ear (HP:0100830)4.08544086
13Abnormality of the fingertips (HP:0001211)4.08442806
14Calf muscle hypertrophy (HP:0008981)3.93969013
15Hyporeflexia of lower limbs (HP:0002600)3.77928312
16Eczematoid dermatitis (HP:0000976)3.71802030
17Ulnar deviation of the wrist (HP:0003049)3.70243492
18Myokymia (HP:0002411)3.62729766
19EMG: myopathic abnormalities (HP:0003458)3.41017306
20Muscle fiber splitting (HP:0003555)3.35092612
21Focal seizures (HP:0007359)3.34485164
22Visual hallucinations (HP:0002367)3.31105932
23Obstructive sleep apnea (HP:0002870)3.22276249
24Abnormality of skeletal muscle fiber size (HP:0012084)3.20591431
25Increased variability in muscle fiber diameter (HP:0003557)3.19303927
26Increased connective tissue (HP:0009025)3.16929358
27Increased IgE level (HP:0003212)3.12470394
28Atonic seizures (HP:0010819)2.95979962
29Abnormality of the calf musculature (HP:0001430)2.94582804
30Myotonia (HP:0002486)2.91917910
31Calcaneovalgus deformity (HP:0001848)2.89949718
32Slender build (HP:0001533)2.89595137
33Muscle stiffness (HP:0003552)2.87677697
34Gastrointestinal infarctions (HP:0005244)2.85577516
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.78673483
36Frequent falls (HP:0002359)2.75786167
37Myositis (HP:0100614)2.72469364
38Spontaneous hematomas (HP:0007420)2.72170582
39Difficulty climbing stairs (HP:0003551)2.72053806
40Myoglobinuria (HP:0002913)2.69630850
41Achilles tendon contracture (HP:0001771)2.68188332
42Recurrent fungal infections (HP:0002841)2.64273312
43Absence seizures (HP:0002121)2.64232552
44Sudden death (HP:0001699)2.63702763
45Deformed tarsal bones (HP:0008119)2.61430600
46Colitis (HP:0002583)2.60019590
47Lower limb amyotrophy (HP:0007210)2.59343748
48Chronic mucocutaneous candidiasis (HP:0002728)2.57055486
49Recurrent cutaneous fungal infections (HP:0011370)2.57055486
50Mildly elevated creatine phosphokinase (HP:0008180)2.55151903
51Urinary urgency (HP:0000012)2.52781705
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52687004
53Abnormality of macrophages (HP:0004311)2.51737837
54Orchitis (HP:0100796)2.51236495
55Absent phalangeal crease (HP:0006109)2.50180807
56Recurrent bacterial skin infections (HP:0005406)2.49223276
57Subaortic stenosis (HP:0001682)2.48834353
58Abnormality of the left ventricular outflow tract (HP:0011103)2.48834353
59Optic neuritis (HP:0100653)2.46912546
60Retrobulbar optic neuritis (HP:0100654)2.46912546
61Distal lower limb amyotrophy (HP:0008944)2.46411368
62Hyperkalemia (HP:0002153)2.44033197
63Cellulitis (HP:0100658)2.42044099
64Recurrent abscess formation (HP:0002722)2.40889817
65Impaired vibration sensation in the lower limbs (HP:0002166)2.40073422
66Dysmetric saccades (HP:0000641)2.39940430
67Meningitis (HP:0001287)2.39028367
68Supranuclear gaze palsy (HP:0000605)2.38178087
69Cerebral inclusion bodies (HP:0100314)2.36278790
70Rapidly progressive (HP:0003678)2.36248444
71Urinary bladder sphincter dysfunction (HP:0002839)2.32869715
72Bundle branch block (HP:0011710)2.30845496
73Neck muscle weakness (HP:0000467)2.30268420
74Generalized tonic-clonic seizures (HP:0002069)2.29738866
75Dialeptic seizures (HP:0011146)2.28772288
76Broad-based gait (HP:0002136)2.28563155
77Epileptic encephalopathy (HP:0200134)2.28000812
78Abnormality of the hip-girdle musculature (HP:0001445)2.27434486
79Abnormality of the musculature of the pelvis (HP:0001469)2.27434486
80Shoulder girdle muscle weakness (HP:0003547)2.26690797
81Gingivitis (HP:0000230)2.26382866
82Dysmetria (HP:0001310)2.26202010
83Abnormality of the Achilles tendon (HP:0005109)2.25311693
84Polycythemia (HP:0001901)2.25309413
85Action tremor (HP:0002345)2.25212202
86Pelvic girdle muscle weakness (HP:0003749)2.23087222
87Prolonged bleeding time (HP:0003010)2.21869224
88Febrile seizures (HP:0002373)2.21220360
89Peritonitis (HP:0002586)2.18188220
90Vasculitis (HP:0002633)2.17524142
91Gastrointestinal stroma tumor (HP:0100723)2.16344017
92Recurrent gram-negative bacterial infections (HP:0005420)2.14726652
93EMG: neuropathic changes (HP:0003445)2.13967219
94Ankle clonus (HP:0011448)2.13368426
95Impaired social interactions (HP:0000735)2.13170353
96Abnormal social behavior (HP:0012433)2.13170353
97Metaphyseal cupping (HP:0003021)2.12946231
98Chronic obstructive pulmonary disease (HP:0006510)2.11744709
99Obstructive lung disease (HP:0006536)2.11744709
100Bowel incontinence (HP:0002607)2.09293613
101Abnormality of the peritoneum (HP:0002585)2.08641748
102Gastrointestinal inflammation (HP:0004386)2.08259748
103Chest pain (HP:0100749)2.07264408
104Abnormality of the lower motor neuron (HP:0002366)2.04735377
105Abnormal finger flexion creases (HP:0006143)2.02520722
106Inflammation of the large intestine (HP:0002037)2.01655978
107Depression (HP:0000716)2.01219405
108Agammaglobulinemia (HP:0004432)2.01179813
109Bronchomalacia (HP:0002780)2.00958440
110Ulnar deviation of finger (HP:0009465)2.00603795
111Recurrent viral infections (HP:0004429)2.00119647
112Proximal amyotrophy (HP:0007126)1.99287666
113Malignant hyperthermia (HP:0002047)1.98577636
114Termporal pattern (HP:0011008)1.98573543
115Insidious onset (HP:0003587)1.98573543
116Poor eye contact (HP:0000817)1.98403394
117Mediastinal lymphadenopathy (HP:0100721)1.98334672
118Disproportionate tall stature (HP:0001519)1.95190740
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.95020592
120Insomnia (HP:0100785)1.94879304
121Recurrent skin infections (HP:0001581)1.93831961
122Progressive cerebellar ataxia (HP:0002073)1.91148177
123Segmental peripheral demyelination/remyelination (HP:0003481)1.91045266
124Cerebral aneurysm (HP:0004944)1.90835693
125Dysdiadochokinesis (HP:0002075)1.90450710
126Hemiplegia (HP:0002301)1.90301706
127Abnormality of the neuromuscular junction (HP:0003398)1.90292410
128Fatigable weakness (HP:0003473)1.90292410
129Increased density of long bones (HP:0006392)1.90228821
130Postural instability (HP:0002172)1.89922094
131Persistence of primary teeth (HP:0006335)1.89164734
132Scapular winging (HP:0003691)1.89090394
133Annular pancreas (HP:0001734)1.88920689
134Abnormality of the calcaneus (HP:0008364)1.87495284
135Viral hepatitis (HP:0006562)1.86604562
136Emphysema (HP:0002097)1.86565817
137Dislocated radial head (HP:0003083)1.86552439
138Asymmetric septal hypertrophy (HP:0001670)1.86482092
139Amblyopia (HP:0000646)1.86074831
140Abnormality of the columella (HP:0009929)1.84901631
141Genetic anticipation (HP:0003743)1.83428434
142Abnormality of binocular vision (HP:0011514)1.81780823
143Diplopia (HP:0000651)1.81780823
144Pointed chin (HP:0000307)1.81305888
145Hemoptysis (HP:0002105)1.80825827
146Limb-girdle muscle weakness (HP:0003325)1.80330001
147Encephalitis (HP:0002383)1.79864696
148Keratoconjunctivitis sicca (HP:0001097)1.79564150
149Abnormal large intestine physiology (HP:0012700)1.79560327
150Broad metatarsal (HP:0001783)1.79267453
151Abnormality of the radial head (HP:0003995)1.79015939
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77681704
153Fetal akinesia sequence (HP:0001989)1.76658797
154Abnormality of incisor morphology (HP:0011063)1.76211477
155Neurofibrillary tangles (HP:0002185)1.76054943
156Nasal polyposis (HP:0100582)1.75375035
157Rhabdomyolysis (HP:0003201)1.75269819
158Recurrent sinusitis (HP:0011108)1.74310786
159Thin ribs (HP:0000883)1.74051493
160Restrictive lung disease (HP:0002091)1.70631383
161Elevated erythrocyte sedimentation rate (HP:0003565)1.70604895
162Onion bulb formation (HP:0003383)1.70391015
163Long eyelashes (HP:0000527)1.70322235
164Arterial thrombosis (HP:0004420)1.70200316
165Macroorchidism (HP:0000053)1.69345540
166Osteomyelitis (HP:0002754)1.67350461
167Easy fatigability (HP:0003388)1.65838141
168Abnormality of the nasal mucosa (HP:0000433)1.65822682
169Ankyloglossia (HP:0010296)1.64839373
170Keratoconjunctivitis (HP:0001096)1.64081668
171Stomatitis (HP:0010280)1.63810005
172Dilatation of the ascending aorta (HP:0005111)1.63341937
173Lymphopenia (HP:0001888)1.59209899
174Chronic otitis media (HP:0000389)1.59109810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.61746743
2NTRK33.51855263
3MAP3K93.21471518
4KSR22.75995674
5OBSCN2.64144991
6PHKG12.59775811
7PHKG22.59775811
8TTN2.54609433
9RIPK42.37243678
10FGFR42.23035160
11DMPK2.22383488
12TRIB32.18914181
13PRKD32.13461873
14PAK61.99739364
15MAP3K131.90602386
16MAP3K41.79446890
17TAOK11.63909692
18MAP2K41.62409131
19BLK1.62334366
20TYK21.60565847
21* MAP3K71.52912679
22MINK11.49795138
23CSK1.45857606
24KSR11.44714004
25SIK21.44358540
26DAPK21.43232951
27TYRO31.43152653
28SMG11.42390514
29FGFR31.39457364
30ERN11.37383534
31PTK2B1.35161376
32MAP3K141.31324207
33NTRK21.29574711
34JAK11.29173314
35LATS11.27155410
36RAF11.23427117
37CAMKK11.22410176
38PRPF4B1.22361391
39BRD41.21212581
40NTRK11.20487917
41CDK51.19618219
42FES1.17556703
43EEF2K1.17448487
44EPHA31.14780381
45PRKCH1.13259910
46ALK1.12097259
47CAMK1G1.12049624
48BTK1.08202964
49RIPK11.06841813
50JAK31.06839794
51GRK61.05163389
52ZAP701.01805703
53MAP3K21.01655447
54MAP3K11.00232905
55IRAK40.99028341
56MTOR0.98588920
57SIK10.98435182
58MAP3K100.98265711
59PKN20.97352662
60PDK10.96702640
61SYK0.96179140
62PNCK0.95759970
63RET0.94572480
64STK110.93532155
65MAPK70.87986139
66STK380.87387131
67BMX0.87268181
68EPHB10.87045677
69MARK20.86596541
70MARK10.83757174
71LMTK20.83695598
72FGR0.83219681
73SGK20.82921092
74MAPK120.81910666
75PDPK10.81527271
76ICK0.80515278
77CAMK10.79143864
78MAPK110.76691824
79PDGFRA0.75795499
80GRK50.75502125
81RPS6KA20.75294632
82IKBKE0.74115246
83MAP3K60.73388414
84SGK10.72097922
85WNK10.71355942
86MAP2K70.70437891
87TBK10.69861961
88DDR20.68970828
89HIPK20.68462179
90SGK30.67960298
91CAMK2B0.67805555
92NEK10.67273992
93RPS6KC10.67141012
94RPS6KL10.67141012
95CAMK40.65748571
96ROCK20.64816310
97MATK0.62620175
98KIT0.62208097
99CAMK2A0.61370034
100LRRK20.60901563
101PTK60.60318331
102SGK4940.60023202
103SGK2230.60023202
104CSF1R0.59852946
105CDK190.59827214
106MOS0.59684218
107MAP2K30.59543430
108DAPK10.57937075
109MAP4K10.57648761
110LATS20.56943432
111PINK10.56440394
112TXK0.56208910
113LYN0.56162209
114DYRK1B0.56023543
115PRKD20.55438618
116CDK120.54821886
117MAP2K10.54686450
118LCK0.54658760
119RPS6KA60.54629486
120ARAF0.54177546
121PAK30.53324029
122PRKCQ0.53087838
123HCK0.52205669
124TRPM70.51815559
125PRKCG0.51430213
126RPS6KA30.50170350
127YES10.50160133
128CDK150.49229670
129PIM10.49216425
130TEC0.48919471
131TNK20.48318439
132ITK0.48288119
133MELK0.47362403
134MAPK100.46409011
135FYN0.44433848
136CDK180.44241732
137CAMK1D0.43980457
138FER0.43192058
139CDK140.42201070
140CDK11A0.41352311
141PDGFRB0.41319473
142PLK20.40717318
143CAMK2G0.37952911
144BMPR20.37226422
145PRKAA20.37122023
146JAK20.35894001
147CDC42BPA0.34202794

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.40941834
2Nicotine addiction_Homo sapiens_hsa050332.05715777
3Circadian entrainment_Homo sapiens_hsa047132.04970012
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00755275
5Oxytocin signaling pathway_Homo sapiens_hsa049211.91573928
6Gastric acid secretion_Homo sapiens_hsa049711.89580609
7Salivary secretion_Homo sapiens_hsa049701.85682575
8Glutamatergic synapse_Homo sapiens_hsa047241.85344933
9Olfactory transduction_Homo sapiens_hsa047401.82014786
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79174446
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76591773
12Amphetamine addiction_Homo sapiens_hsa050311.75551261
13Acute myeloid leukemia_Homo sapiens_hsa052211.73019023
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69857103
15Calcium signaling pathway_Homo sapiens_hsa040201.67056780
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65675217
17GnRH signaling pathway_Homo sapiens_hsa049121.64759553
18Leishmaniasis_Homo sapiens_hsa051401.63690694
19Notch signaling pathway_Homo sapiens_hsa043301.62630281
20GABAergic synapse_Homo sapiens_hsa047271.59481002
21Renin secretion_Homo sapiens_hsa049241.54441844
22Morphine addiction_Homo sapiens_hsa050321.51727315
23Cholinergic synapse_Homo sapiens_hsa047251.50937473
24Long-term depression_Homo sapiens_hsa047301.48235747
25Dopaminergic synapse_Homo sapiens_hsa047281.46940261
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45481243
27Dilated cardiomyopathy_Homo sapiens_hsa054141.43792449
28Insulin secretion_Homo sapiens_hsa049111.37561746
29Synaptic vesicle cycle_Homo sapiens_hsa047211.35237631
30Glioma_Homo sapiens_hsa052141.34528087
31VEGF signaling pathway_Homo sapiens_hsa043701.33832899
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32792240
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32285968
34Pancreatic cancer_Homo sapiens_hsa052121.31965178
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28672039
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28541885
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28256427
38Influenza A_Homo sapiens_hsa051641.23061495
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.21415278
40Endometrial cancer_Homo sapiens_hsa052131.21282145
41Measles_Homo sapiens_hsa051621.20194249
42Type II diabetes mellitus_Homo sapiens_hsa049301.19604432
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18525290
44Toxoplasmosis_Homo sapiens_hsa051451.16429684
45Allograft rejection_Homo sapiens_hsa053301.16099066
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15238198
47cAMP signaling pathway_Homo sapiens_hsa040241.14780345
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14727318
49Dorso-ventral axis formation_Homo sapiens_hsa043201.13767575
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.13405583
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11456586
52Gap junction_Homo sapiens_hsa045401.09106728
53ErbB signaling pathway_Homo sapiens_hsa040121.08675264
54Graft-versus-host disease_Homo sapiens_hsa053321.07523238
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06184010
56Hepatitis B_Homo sapiens_hsa051611.05889242
57Primary immunodeficiency_Homo sapiens_hsa053401.05087399
58Estrogen signaling pathway_Homo sapiens_hsa049151.05069649
59MAPK signaling pathway_Homo sapiens_hsa040101.03555889
60Phospholipase D signaling pathway_Homo sapiens_hsa040721.03223213
61* Tuberculosis_Homo sapiens_hsa051521.02439527
62Autoimmune thyroid disease_Homo sapiens_hsa053201.01885796
63Serotonergic synapse_Homo sapiens_hsa047261.01433795
64TNF signaling pathway_Homo sapiens_hsa046680.99112478
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97872877
66Colorectal cancer_Homo sapiens_hsa052100.97405278
67Staphylococcus aureus infection_Homo sapiens_hsa051500.97353794
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.96542628
69Choline metabolism in cancer_Homo sapiens_hsa052310.96010041
70Cardiac muscle contraction_Homo sapiens_hsa042600.95026904
71mTOR signaling pathway_Homo sapiens_hsa041500.94516240
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93539639
73Glucagon signaling pathway_Homo sapiens_hsa049220.92895539
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.92332273
75T cell receptor signaling pathway_Homo sapiens_hsa046600.91184594
76Hepatitis C_Homo sapiens_hsa051600.90047351
77Axon guidance_Homo sapiens_hsa043600.89725531
78Cocaine addiction_Homo sapiens_hsa050300.89481445
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88647382
80Insulin signaling pathway_Homo sapiens_hsa049100.87450240
81Melanogenesis_Homo sapiens_hsa049160.86009449
82Taste transduction_Homo sapiens_hsa047420.84789795
83Malaria_Homo sapiens_hsa051440.84548647
84Herpes simplex infection_Homo sapiens_hsa051680.83766774
85B cell receptor signaling pathway_Homo sapiens_hsa046620.81998543
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81450404
87Non-small cell lung cancer_Homo sapiens_hsa052230.80784735
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79876585
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79341949
90Pancreatic secretion_Homo sapiens_hsa049720.78717978
91FoxO signaling pathway_Homo sapiens_hsa040680.78526258
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76832316
93Adherens junction_Homo sapiens_hsa045200.76737214
94Renal cell carcinoma_Homo sapiens_hsa052110.76668022
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75476578
96MicroRNAs in cancer_Homo sapiens_hsa052060.74927592
97Prostate cancer_Homo sapiens_hsa052150.74291550
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73765838
99Rap1 signaling pathway_Homo sapiens_hsa040150.73135299
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.72768912
101Apoptosis_Homo sapiens_hsa042100.72645575
102Insulin resistance_Homo sapiens_hsa049310.70741502
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.70386180
104Other glycan degradation_Homo sapiens_hsa005110.69815428
105Circadian rhythm_Homo sapiens_hsa047100.69756701
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69207058
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69055784
108Focal adhesion_Homo sapiens_hsa045100.68603785
109Platelet activation_Homo sapiens_hsa046110.68207695
110Type I diabetes mellitus_Homo sapiens_hsa049400.67918253
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67626533
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.67087928
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66241766
114HTLV-I infection_Homo sapiens_hsa051660.65792621
115Hematopoietic cell lineage_Homo sapiens_hsa046400.63524339
116Bladder cancer_Homo sapiens_hsa052190.63293192
117Thyroid cancer_Homo sapiens_hsa052160.63098174
118Chronic myeloid leukemia_Homo sapiens_hsa052200.62728215
119HIF-1 signaling pathway_Homo sapiens_hsa040660.62358996
120Endocytosis_Homo sapiens_hsa041440.62351565
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62343759
122Chemokine signaling pathway_Homo sapiens_hsa040620.61968820
123Osteoclast differentiation_Homo sapiens_hsa043800.61931890
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61040310
125Inositol phosphate metabolism_Homo sapiens_hsa005620.60872013
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60566562
127* Ras signaling pathway_Homo sapiens_hsa040140.59266721
128Antigen processing and presentation_Homo sapiens_hsa046120.58608993
129African trypanosomiasis_Homo sapiens_hsa051430.58279345
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58195233
131Tight junction_Homo sapiens_hsa045300.57914877
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.57909523
133Viral myocarditis_Homo sapiens_hsa054160.56692913
134Oocyte meiosis_Homo sapiens_hsa041140.56201938
135Proteoglycans in cancer_Homo sapiens_hsa052050.54046755
136AMPK signaling pathway_Homo sapiens_hsa041520.53098272
137Nitrogen metabolism_Homo sapiens_hsa009100.52757629
138Amoebiasis_Homo sapiens_hsa051460.51939400
139Prolactin signaling pathway_Homo sapiens_hsa049170.51805559
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50650205
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.50028172

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