

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.72865546 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.49797938 |
| 3 | vocalization behavior (GO:0071625) | 5.39620464 |
| 4 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.37391232 |
| 5 | locomotory exploration behavior (GO:0035641) | 5.31188473 |
| 6 | synaptic vesicle maturation (GO:0016188) | 5.18917021 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 5.06063322 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.97123120 |
| 9 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.87548240 |
| 10 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.82582520 |
| 11 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.75997979 |
| 12 | neuron cell-cell adhesion (GO:0007158) | 4.70724108 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.65176513 |
| 14 | glutamate secretion (GO:0014047) | 4.61559255 |
| 15 | protein localization to synapse (GO:0035418) | 4.49469336 |
| 16 | synaptic transmission, glutamatergic (GO:0035249) | 4.42528702 |
| 17 | glutamate receptor signaling pathway (GO:0007215) | 4.40946658 |
| 18 | regulation of synaptic vesicle transport (GO:1902803) | 4.31746549 |
| 19 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.18367769 |
| 20 | neuronal action potential propagation (GO:0019227) | 4.15616362 |
| 21 | neuron-neuron synaptic transmission (GO:0007270) | 4.13252067 |
| 22 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.10960707 |
| 23 | exploration behavior (GO:0035640) | 4.10830156 |
| 24 | neurotransmitter secretion (GO:0007269) | 4.10484151 |
| 25 | behavioral response to nicotine (GO:0035095) | 4.06158850 |
| 26 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.05366132 |
| 27 | serotonin metabolic process (GO:0042428) | 3.91612157 |
| 28 | long-term memory (GO:0007616) | 3.86677039 |
| 29 | dendritic spine morphogenesis (GO:0060997) | 3.85794269 |
| 30 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.83840130 |
| 31 | positive regulation of membrane potential (GO:0045838) | 3.83158412 |
| 32 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.78732673 |
| 33 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.75118143 |
| 34 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.74922287 |
| 35 | primary amino compound metabolic process (GO:1901160) | 3.71609056 |
| 36 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.70506545 |
| 37 | regulation of synapse structural plasticity (GO:0051823) | 3.70273570 |
| 38 | regulation of postsynaptic membrane potential (GO:0060078) | 3.70039506 |
| 39 | gamma-aminobutyric acid transport (GO:0015812) | 3.65880984 |
| 40 | cellular potassium ion homeostasis (GO:0030007) | 3.65039710 |
| 41 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.64872231 |
| 42 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.62883506 |
| 43 | synaptic vesicle endocytosis (GO:0048488) | 3.62641576 |
| 44 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.54025315 |
| 45 | neuronal action potential (GO:0019228) | 3.46459278 |
| 46 | transmission of nerve impulse (GO:0019226) | 3.43257537 |
| 47 | neurotransmitter transport (GO:0006836) | 3.42513869 |
| 48 | regulation of synaptic plasticity (GO:0048167) | 3.40514474 |
| 49 | layer formation in cerebral cortex (GO:0021819) | 3.40458943 |
| 50 | postsynaptic membrane organization (GO:0001941) | 3.40268040 |
| 51 | regulation of neurotransmitter secretion (GO:0046928) | 3.39683562 |
| 52 | proline transport (GO:0015824) | 3.38927579 |
| 53 | chemosensory behavior (GO:0007635) | 3.38870872 |
| 54 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.37552606 |
| 55 | neuron recognition (GO:0008038) | 3.36747807 |
| 56 | membrane depolarization during action potential (GO:0086010) | 3.35655510 |
| 57 | long-term synaptic potentiation (GO:0060291) | 3.32694077 |
| 58 | protein polyglutamylation (GO:0018095) | 3.32232552 |
| 59 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.31081485 |
| 60 | presynaptic membrane assembly (GO:0097105) | 3.30627225 |
| 61 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.30598615 |
| 62 | innervation (GO:0060384) | 3.28651710 |
| 63 | regulation of vesicle fusion (GO:0031338) | 3.28005394 |
| 64 | detection of calcium ion (GO:0005513) | 3.27652578 |
| 65 | membrane depolarization (GO:0051899) | 3.24452847 |
| 66 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.24235637 |
| 67 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.24004253 |
| 68 | positive regulation of synapse maturation (GO:0090129) | 3.22830320 |
| 69 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.21831315 |
| 70 | membrane hyperpolarization (GO:0060081) | 3.20116959 |
| 71 | response to pheromone (GO:0019236) | 3.19562945 |
| 72 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.19165092 |
| 73 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.17753455 |
| 74 | calcium ion-dependent exocytosis (GO:0017156) | 3.14645090 |
| 75 | activation of protein kinase A activity (GO:0034199) | 3.14492116 |
| 76 | auditory behavior (GO:0031223) | 3.14211443 |
| 77 | startle response (GO:0001964) | 3.13659280 |
| 78 | response to auditory stimulus (GO:0010996) | 3.11660227 |
| 79 | regulation of neurotransmitter transport (GO:0051588) | 3.11564405 |
| 80 | response to histamine (GO:0034776) | 3.11351639 |
| 81 | positive regulation of neurotransmitter transport (GO:0051590) | 3.10646547 |
| 82 | regulation of neurotransmitter levels (GO:0001505) | 3.10286699 |
| 83 | axonal fasciculation (GO:0007413) | 3.08673589 |
| 84 | behavioral defense response (GO:0002209) | 3.07884992 |
| 85 | behavioral fear response (GO:0001662) | 3.07884992 |
| 86 | neuromuscular process controlling balance (GO:0050885) | 3.06916093 |
| 87 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.05816598 |
| 88 | synapse assembly (GO:0007416) | 3.05800029 |
| 89 | learning (GO:0007612) | 3.05275834 |
| 90 | cerebellar granule cell differentiation (GO:0021707) | 3.04490046 |
| 91 | presynaptic membrane organization (GO:0097090) | 3.04206007 |
| 92 | neuromuscular synaptic transmission (GO:0007274) | 3.03809160 |
| 93 | dendritic spine organization (GO:0097061) | 3.03626784 |
| 94 | retinal cone cell development (GO:0046549) | 3.01411513 |
| 95 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.01354522 |
| 96 | detection of light stimulus involved in visual perception (GO:0050908) | 3.00877646 |
| 97 | detection of light stimulus involved in sensory perception (GO:0050962) | 3.00877646 |
| 98 | dendrite morphogenesis (GO:0048813) | 3.00583606 |
| 99 | fear response (GO:0042596) | 3.00104688 |
| 100 | reflex (GO:0060004) | 2.99163769 |
| 101 | synaptic transmission (GO:0007268) | 2.98923740 |
| 102 | neuromuscular process controlling posture (GO:0050884) | 2.97363287 |
| 103 | long term synaptic depression (GO:0060292) | 2.97124865 |
| 104 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.96674704 |
| 105 | prepulse inhibition (GO:0060134) | 2.93749490 |
| 106 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.91928913 |
| 107 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.91193508 |
| 108 | protein localization to cilium (GO:0061512) | 2.90883621 |
| 109 | regulation of synaptic transmission (GO:0050804) | 2.90084723 |
| 110 | glycine transport (GO:0015816) | 2.89553613 |
| 111 | positive regulation of synaptic transmission (GO:0050806) | 2.87931609 |
| 112 | social behavior (GO:0035176) | 2.87466890 |
| 113 | intraspecies interaction between organisms (GO:0051703) | 2.87466890 |
| 114 | regulation of synapse maturation (GO:0090128) | 2.86728074 |
| 115 | vesicle transport along microtubule (GO:0047496) | 2.85869393 |
| 116 | phosphorelay signal transduction system (GO:0000160) | 2.84935676 |
| 117 | multicellular organismal signaling (GO:0035637) | 2.82998069 |
| 118 | potassium ion transmembrane transport (GO:0071805) | 2.81368733 |
| 119 | cellular potassium ion transport (GO:0071804) | 2.81368733 |
| 120 | regulation of action potential (GO:0098900) | 2.79817452 |
| 121 | glycosphingolipid biosynthetic process (GO:0006688) | 2.78967625 |
| 122 | action potential (GO:0001508) | 2.77382990 |
| 123 | cellular ketone body metabolic process (GO:0046950) | 2.76583607 |
| 124 | adult walking behavior (GO:0007628) | 2.76104125 |
| 125 | righting reflex (GO:0060013) | 2.75423928 |
| 126 | indole-containing compound metabolic process (GO:0042430) | 2.74530919 |
| 127 | regulation of neurotransmitter uptake (GO:0051580) | 2.74352698 |
| 128 | neuronal ion channel clustering (GO:0045161) | 2.70480210 |
| 129 | C4-dicarboxylate transport (GO:0015740) | 2.69526644 |
| 130 | adult behavior (GO:0030534) | 2.68870280 |
| 131 | negative regulation of dendrite development (GO:2000171) | 2.67562760 |
| 132 | potassium ion transport (GO:0006813) | 2.67549640 |
| 133 | mechanosensory behavior (GO:0007638) | 2.66506851 |
| 134 | response to amphetamine (GO:0001975) | 2.65980839 |
| 135 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.61456668 |
| 136 | positive regulation of meiosis (GO:0045836) | 2.56136083 |
| 137 | potassium ion import (GO:0010107) | 2.55646311 |
| 138 | positive regulation of action potential (GO:0045760) | 2.54578862 |
| 139 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.54515162 |
| 140 | axoneme assembly (GO:0035082) | 2.54159167 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.20831660 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.95858453 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.92325476 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.91651578 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.82235669 |
| 6 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.67393192 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.50977164 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.50977164 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.46031467 |
| 10 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.45685379 |
| 11 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.43508117 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.39619628 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.34832494 |
| 14 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.33476534 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.29959625 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.25750715 |
| 17 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.19590288 |
| 18 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.18255384 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.13713729 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.10166806 |
| 21 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.07387317 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.07082488 |
| 23 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.03708690 |
| 24 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.96007416 |
| 25 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.87955549 |
| 26 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.85334316 |
| 27 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.80753340 |
| 28 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.79595171 |
| 29 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.78205511 |
| 30 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.75927887 |
| 31 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.70206419 |
| 32 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.67319287 |
| 33 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.67313688 |
| 34 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.66227627 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.64541909 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.64004986 |
| 37 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.63272295 |
| 38 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.62636165 |
| 39 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.52404112 |
| 40 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.52372927 |
| 41 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51522869 |
| 42 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.42301677 |
| 43 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.39865463 |
| 44 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.39085384 |
| 45 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.38960252 |
| 46 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.38361939 |
| 47 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.36439450 |
| 48 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.34239280 |
| 49 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.34235269 |
| 50 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.33485756 |
| 51 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.33485756 |
| 52 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.32795290 |
| 53 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.30495677 |
| 54 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.30235830 |
| 55 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.30228864 |
| 56 | AR_25329375_ChIP-Seq_VCAP_Human | 1.27974570 |
| 57 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.26166958 |
| 58 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.26021116 |
| 59 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.24481836 |
| 60 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.24419455 |
| 61 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.23582748 |
| 62 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.22909290 |
| 63 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.22034065 |
| 64 | EWS_26573619_Chip-Seq_HEK293_Human | 1.20877846 |
| 65 | * AR_19668381_ChIP-Seq_PC3_Human | 1.20209098 |
| 66 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.19904517 |
| 67 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.16980362 |
| 68 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.16816385 |
| 69 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.16087857 |
| 70 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.15861382 |
| 71 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.15657651 |
| 72 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.14373525 |
| 73 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.14340428 |
| 74 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.13996333 |
| 75 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.12620047 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.12440755 |
| 77 | * ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.12061515 |
| 78 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.11704823 |
| 79 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.11088433 |
| 80 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 1.09920645 |
| 81 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.08630473 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08630473 |
| 83 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.08174977 |
| 84 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.07486020 |
| 85 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.07063893 |
| 86 | * KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06609026 |
| 87 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.06495490 |
| 88 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.06460309 |
| 89 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06132630 |
| 90 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05658316 |
| 91 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.05545664 |
| 92 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04890519 |
| 93 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.04106140 |
| 94 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.02659565 |
| 95 | KDM2B_26808549_Chip-Seq_REH_Human | 1.02655342 |
| 96 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.02185575 |
| 97 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.02141821 |
| 98 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.01978533 |
| 99 | FUS_26573619_Chip-Seq_HEK293_Human | 1.01914158 |
| 100 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.01337731 |
| 101 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.00673839 |
| 102 | VDR_22108803_ChIP-Seq_LS180_Human | 1.00107796 |
| 103 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.99363131 |
| 104 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.99132244 |
| 105 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.98825118 |
| 106 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.97826059 |
| 107 | * RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.97197151 |
| 108 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96805741 |
| 109 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96805741 |
| 110 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96707858 |
| 111 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.96118149 |
| 112 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.96077388 |
| 113 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.95998497 |
| 114 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.94537767 |
| 115 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.94141997 |
| 116 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94131808 |
| 117 | * CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.92293564 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.93068170 |
| 2 | MP0003880_abnormal_central_pattern | 4.44527797 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.93734306 |
| 4 | MP0004270_analgesia | 3.54523992 |
| 5 | MP0009745_abnormal_behavioral_response | 3.26576239 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.16272215 |
| 7 | MP0009046_muscle_twitch | 3.15457464 |
| 8 | MP0001968_abnormal_touch/_nociception | 3.06169929 |
| 9 | MP0002064_seizures | 2.96984732 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.92192985 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.83315282 |
| 12 | MP0001486_abnormal_startle_reflex | 2.64679547 |
| 13 | MP0002734_abnormal_mechanical_nocicepti | 2.62821701 |
| 14 | MP0002272_abnormal_nervous_system | 2.62734330 |
| 15 | MP0002735_abnormal_chemical_nociception | 2.41440533 |
| 16 | MP0005645_abnormal_hypothalamus_physiol | 2.36536198 |
| 17 | MP0002736_abnormal_nociception_after | 2.32396388 |
| 18 | MP0002822_catalepsy | 2.30766225 |
| 19 | MP0001984_abnormal_olfaction | 2.24393083 |
| 20 | MP0001501_abnormal_sleep_pattern | 2.21547903 |
| 21 | MP0002067_abnormal_sensory_capabilities | 2.07203429 |
| 22 | MP0001440_abnormal_grooming_behavior | 2.05350123 |
| 23 | MP0005646_abnormal_pituitary_gland | 2.02568481 |
| 24 | MP0002733_abnormal_thermal_nociception | 2.00460712 |
| 25 | MP0003787_abnormal_imprinting | 1.97625799 |
| 26 | MP0002184_abnormal_innervation | 1.97550684 |
| 27 | MP0003879_abnormal_hair_cell | 1.96562860 |
| 28 | MP0001970_abnormal_pain_threshold | 1.94788837 |
| 29 | MP0002909_abnormal_adrenal_gland | 1.90082632 |
| 30 | MP0002557_abnormal_social/conspecific_i | 1.88780478 |
| 31 | MP0008569_lethality_at_weaning | 1.85345434 |
| 32 | MP0001188_hyperpigmentation | 1.76212636 |
| 33 | MP0006276_abnormal_autonomic_nervous | 1.73523252 |
| 34 | MP0009780_abnormal_chondrocyte_physiolo | 1.72711647 |
| 35 | MP0005386_behavior/neurological_phenoty | 1.69112619 |
| 36 | MP0004924_abnormal_behavior | 1.69112619 |
| 37 | MP0000778_abnormal_nervous_system | 1.66694138 |
| 38 | MP0004811_abnormal_neuron_physiology | 1.62001847 |
| 39 | MP0010386_abnormal_urinary_bladder | 1.61216490 |
| 40 | MP0001502_abnormal_circadian_rhythm | 1.53426095 |
| 41 | MP0000955_abnormal_spinal_cord | 1.44234762 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.38591127 |
| 43 | MP0004858_abnormal_nervous_system | 1.36697203 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.34222212 |
| 45 | MP0003646_muscle_fatigue | 1.31095935 |
| 46 | MP0001529_abnormal_vocalization | 1.28800495 |
| 47 | MP0002102_abnormal_ear_morphology | 1.28607236 |
| 48 | MP0004742_abnormal_vestibular_system | 1.27609326 |
| 49 | MP0004885_abnormal_endolymph | 1.26434384 |
| 50 | MP0003633_abnormal_nervous_system | 1.24174303 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.23328808 |
| 52 | MP0003122_maternal_imprinting | 1.22176584 |
| 53 | MP0002653_abnormal_ependyma_morphology | 1.19405720 |
| 54 | MP0004142_abnormal_muscle_tone | 1.17864045 |
| 55 | MP0002638_abnormal_pupillary_reflex | 1.17439488 |
| 56 | MP0003195_calcinosis | 1.15887599 |
| 57 | MP0000569_abnormal_digit_pigmentation | 1.13250647 |
| 58 | MP0006292_abnormal_olfactory_placode | 1.11591967 |
| 59 | MP0003329_amyloid_beta_deposits | 1.10860433 |
| 60 | MP0001905_abnormal_dopamine_level | 1.06985911 |
| 61 | MP0004145_abnormal_muscle_electrophysio | 1.06270365 |
| 62 | MP0002229_neurodegeneration | 1.04745654 |
| 63 | MP0002152_abnormal_brain_morphology | 1.03248835 |
| 64 | MP0004133_heterotaxia | 1.02700416 |
| 65 | MP0000631_abnormal_neuroendocrine_gland | 1.01849107 |
| 66 | MP0000013_abnormal_adipose_tissue | 1.01580116 |
| 67 | MP0002928_abnormal_bile_duct | 1.00436070 |
| 68 | MP0003631_nervous_system_phenotype | 0.99884903 |
| 69 | MP0004147_increased_porphyrin_level | 0.98998101 |
| 70 | MP0003121_genomic_imprinting | 0.98142101 |
| 71 | MP0001485_abnormal_pinna_reflex | 0.97757383 |
| 72 | MP0002069_abnormal_eating/drinking_beha | 0.97282171 |
| 73 | MP0005499_abnormal_olfactory_system | 0.96973122 |
| 74 | MP0005394_taste/olfaction_phenotype | 0.96973122 |
| 75 | MP0001963_abnormal_hearing_physiology | 0.96649917 |
| 76 | MP0004043_abnormal_pH_regulation | 0.92991137 |
| 77 | MP0006072_abnormal_retinal_apoptosis | 0.89222602 |
| 78 | MP0005410_abnormal_fertilization | 0.89097824 |
| 79 | MP0008872_abnormal_physiological_respon | 0.85847931 |
| 80 | MP0002752_abnormal_somatic_nervous | 0.84655597 |
| 81 | MP0001986_abnormal_taste_sensitivity | 0.83607076 |
| 82 | MP0003119_abnormal_digestive_system | 0.83083304 |
| 83 | MP0008874_decreased_physiological_sensi | 0.82076209 |
| 84 | MP0005409_darkened_coat_color | 0.81811617 |
| 85 | MP0003283_abnormal_digestive_organ | 0.81640319 |
| 86 | MP0004085_abnormal_heartbeat | 0.76120626 |
| 87 | MP0005535_abnormal_body_temperature | 0.75804993 |
| 88 | MP0001944_abnormal_pancreas_morphology | 0.74667715 |
| 89 | MP0005379_endocrine/exocrine_gland_phen | 0.74390940 |
| 90 | MP0003698_abnormal_male_reproductive | 0.74272007 |
| 91 | MP0002876_abnormal_thyroid_physiology | 0.73904941 |
| 92 | MP0002938_white_spotting | 0.73708430 |
| 93 | MP0002234_abnormal_pharynx_morphology | 0.73591962 |
| 94 | MP0003634_abnormal_glial_cell | 0.71380186 |
| 95 | MP0001664_abnormal_digestion | 0.71274386 |
| 96 | MP0002160_abnormal_reproductive_system | 0.70980815 |
| 97 | MP0001177_atelectasis | 0.70742459 |
| 98 | MP0002751_abnormal_autonomic_nervous | 0.70245945 |
| 99 | MP0002163_abnormal_gland_morphology | 0.69852262 |
| 100 | MP0003183_abnormal_peptide_metabolism | 0.68777370 |
| 101 | MP0005167_abnormal_blood-brain_barrier | 0.68074541 |
| 102 | MP0000427_abnormal_hair_cycle | 0.66071689 |
| 103 | MP0008877_abnormal_DNA_methylation | 0.65784203 |
| 104 | MP0002837_dystrophic_cardiac_calcinosis | 0.65683494 |
| 105 | MP0008961_abnormal_basal_metabolism | 0.64832533 |
| 106 | MP0005377_hearing/vestibular/ear_phenot | 0.64825101 |
| 107 | MP0003878_abnormal_ear_physiology | 0.64825101 |
| 108 | MP0003137_abnormal_impulse_conducting | 0.64632341 |
| 109 | MP0002090_abnormal_vision | 0.63759201 |
| 110 | MP0005195_abnormal_posterior_eye | 0.63326337 |
| 111 | MP0005253_abnormal_eye_physiology | 0.62599670 |
| 112 | MP0003632_abnormal_nervous_system | 0.62399168 |
| 113 | MP0000026_abnormal_inner_ear | 0.62240491 |
| 114 | MP0002693_abnormal_pancreas_physiology | 0.60892842 |
| 115 | MP0003172_abnormal_lysosome_physiology | 0.60868467 |
| 116 | MP0003690_abnormal_glial_cell | 0.58653241 |
| 117 | MP0003045_fibrosis | 0.57193126 |
| 118 | MP0000920_abnormal_myelination | 0.54344165 |
| 119 | MP0001765_abnormal_ion_homeostasis | 0.53061119 |
| 120 | MP0005171_absent_coat_pigmentation | 0.53040546 |
| 121 | MP0000678_abnormal_parathyroid_gland | 0.52842661 |
| 122 | MP0001299_abnormal_eye_distance/ | 0.52536095 |
| 123 | MP0003075_altered_response_to | 0.52144032 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.80406988 |
| 2 | Myokymia (HP:0002411) | 5.93865603 |
| 3 | Focal seizures (HP:0007359) | 5.67697932 |
| 4 | Febrile seizures (HP:0002373) | 5.24356079 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.05411316 |
| 6 | Visual hallucinations (HP:0002367) | 4.93526869 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 4.71179590 |
| 8 | Atonic seizures (HP:0010819) | 4.39481493 |
| 9 | Absence seizures (HP:0002121) | 4.23923090 |
| 10 | Generalized tonic-clonic seizures (HP:0002069) | 3.94283287 |
| 11 | Dialeptic seizures (HP:0011146) | 3.88549051 |
| 12 | Action tremor (HP:0002345) | 3.67348289 |
| 13 | Broad-based gait (HP:0002136) | 3.67257937 |
| 14 | Gaze-evoked nystagmus (HP:0000640) | 3.63958874 |
| 15 | Hyperventilation (HP:0002883) | 3.51794227 |
| 16 | Poor eye contact (HP:0000817) | 3.29135152 |
| 17 | Pancreatic cysts (HP:0001737) | 3.26626137 |
| 18 | True hermaphroditism (HP:0010459) | 3.13585487 |
| 19 | Truncal ataxia (HP:0002078) | 3.09620524 |
| 20 | Pancreatic fibrosis (HP:0100732) | 3.08729431 |
| 21 | Nephronophthisis (HP:0000090) | 3.08503283 |
| 22 | Molar tooth sign on MRI (HP:0002419) | 2.98001542 |
| 23 | Abnormality of midbrain morphology (HP:0002418) | 2.98001542 |
| 24 | Epileptiform EEG discharges (HP:0011182) | 2.91878961 |
| 25 | Congenital stationary night blindness (HP:0007642) | 2.91660829 |
| 26 | Genetic anticipation (HP:0003743) | 2.91590807 |
| 27 | Dysdiadochokinesis (HP:0002075) | 2.88617661 |
| 28 | Anxiety (HP:0000739) | 2.84153116 |
| 29 | Impaired smooth pursuit (HP:0007772) | 2.84062364 |
| 30 | Impaired social interactions (HP:0000735) | 2.83753930 |
| 31 | Abnormal social behavior (HP:0012433) | 2.83753930 |
| 32 | Depression (HP:0000716) | 2.83333141 |
| 33 | Excessive salivation (HP:0003781) | 2.82670698 |
| 34 | Drooling (HP:0002307) | 2.82670698 |
| 35 | Supranuclear gaze palsy (HP:0000605) | 2.81190458 |
| 36 | Papilledema (HP:0001085) | 2.79716974 |
| 37 | EEG with generalized epileptiform discharges (HP:0011198) | 2.77782768 |
| 38 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.74653735 |
| 39 | Agitation (HP:0000713) | 2.73227812 |
| 40 | Ankle clonus (HP:0011448) | 2.73157637 |
| 41 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.71149052 |
| 42 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.70924455 |
| 43 | Dysmetria (HP:0001310) | 2.69354345 |
| 44 | Amblyopia (HP:0000646) | 2.62615744 |
| 45 | Abnormal eating behavior (HP:0100738) | 2.62469910 |
| 46 | Hemiparesis (HP:0001269) | 2.61296216 |
| 47 | Cystic liver disease (HP:0006706) | 2.56421837 |
| 48 | Abnormality of the renal medulla (HP:0100957) | 2.55698388 |
| 49 | Scanning speech (HP:0002168) | 2.55625910 |
| 50 | Hypsarrhythmia (HP:0002521) | 2.54490301 |
| 51 | Absent speech (HP:0001344) | 2.53673342 |
| 52 | Absent/shortened dynein arms (HP:0200106) | 2.49103345 |
| 53 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.49103345 |
| 54 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.49041140 |
| 55 | Fetal akinesia sequence (HP:0001989) | 2.40814708 |
| 56 | Abnormality of binocular vision (HP:0011514) | 2.39900967 |
| 57 | Diplopia (HP:0000651) | 2.39900967 |
| 58 | Chronic hepatic failure (HP:0100626) | 2.39240262 |
| 59 | Postural instability (HP:0002172) | 2.35790463 |
| 60 | Attenuation of retinal blood vessels (HP:0007843) | 2.34622527 |
| 61 | Stereotypic behavior (HP:0000733) | 2.34144125 |
| 62 | Gait imbalance (HP:0002141) | 2.33274345 |
| 63 | Mutism (HP:0002300) | 2.31802092 |
| 64 | Limb dystonia (HP:0002451) | 2.28624972 |
| 65 | Blue irides (HP:0000635) | 2.25523752 |
| 66 | Genital tract atresia (HP:0001827) | 2.21755685 |
| 67 | Abnormality of the renal cortex (HP:0011035) | 2.19424215 |
| 68 | Protruding tongue (HP:0010808) | 2.18675071 |
| 69 | Abnormal ciliary motility (HP:0012262) | 2.18105543 |
| 70 | Vaginal atresia (HP:0000148) | 2.17823066 |
| 71 | Torticollis (HP:0000473) | 2.16188605 |
| 72 | Type II lissencephaly (HP:0007260) | 2.15020377 |
| 73 | Polydipsia (HP:0001959) | 2.13647341 |
| 74 | Abnormal drinking behavior (HP:0030082) | 2.13647341 |
| 75 | Abolished electroretinogram (ERG) (HP:0000550) | 2.13124673 |
| 76 | Hemiplegia (HP:0002301) | 2.11633773 |
| 77 | Progressive inability to walk (HP:0002505) | 2.10943869 |
| 78 | Generalized hypopigmentation of hair (HP:0011358) | 2.10697468 |
| 79 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.09088130 |
| 80 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.08572482 |
| 81 | Spastic gait (HP:0002064) | 2.06655174 |
| 82 | Hypothermia (HP:0002045) | 2.03909826 |
| 83 | Decreased central vision (HP:0007663) | 2.03739716 |
| 84 | Medial flaring of the eyebrow (HP:0010747) | 2.02710599 |
| 85 | Inability to walk (HP:0002540) | 2.01744008 |
| 86 | Focal dystonia (HP:0004373) | 2.00923660 |
| 87 | Intention tremor (HP:0002080) | 1.99888067 |
| 88 | Congenital primary aphakia (HP:0007707) | 1.99782823 |
| 89 | Sclerocornea (HP:0000647) | 1.97347278 |
| 90 | Impaired vibratory sensation (HP:0002495) | 1.96928858 |
| 91 | Abnormality of the labia minora (HP:0012880) | 1.96763369 |
| 92 | Abnormal EKG (HP:0003115) | 1.95814513 |
| 93 | Abnormality of salivation (HP:0100755) | 1.95210284 |
| 94 | Congenital sensorineural hearing impairment (HP:0008527) | 1.94275198 |
| 95 | Pheochromocytoma (HP:0002666) | 1.94066105 |
| 96 | Dysmetric saccades (HP:0000641) | 1.93537172 |
| 97 | Status epilepticus (HP:0002133) | 1.92164211 |
| 98 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.91237277 |
| 99 | Nephrogenic diabetes insipidus (HP:0009806) | 1.91175084 |
| 100 | Bradykinesia (HP:0002067) | 1.90877038 |
| 101 | Prolonged QT interval (HP:0001657) | 1.90439695 |
| 102 | Ventricular fibrillation (HP:0001663) | 1.90318549 |
| 103 | Widely spaced teeth (HP:0000687) | 1.90298013 |
| 104 | Generalized myoclonic seizures (HP:0002123) | 1.90143250 |
| 105 | Dyskinesia (HP:0100660) | 1.89926817 |
| 106 | Optic nerve hypoplasia (HP:0000609) | 1.89157787 |
| 107 | Polyphagia (HP:0002591) | 1.88687234 |
| 108 | Abnormality of the corticospinal tract (HP:0002492) | 1.88385517 |
| 109 | Ketoacidosis (HP:0001993) | 1.87383423 |
| 110 | Large for gestational age (HP:0001520) | 1.87379023 |
| 111 | Obstructive sleep apnea (HP:0002870) | 1.86332041 |
| 112 | Urinary urgency (HP:0000012) | 1.86232108 |
| 113 | Poor coordination (HP:0002370) | 1.83781745 |
| 114 | Specific learning disability (HP:0001328) | 1.83177670 |
| 115 | Furrowed tongue (HP:0000221) | 1.81761232 |
| 116 | Pendular nystagmus (HP:0012043) | 1.81144621 |
| 117 | Inappropriate behavior (HP:0000719) | 1.80776515 |
| 118 | Decreased circulating renin level (HP:0003351) | 1.80203721 |
| 119 | Gait ataxia (HP:0002066) | 1.79743232 |
| 120 | Incomplete penetrance (HP:0003829) | 1.76839139 |
| 121 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.75765611 |
| 122 | Thyroid-stimulating hormone excess (HP:0002925) | 1.75686207 |
| 123 | Psychosis (HP:0000709) | 1.75479585 |
| 124 | Retinal dysplasia (HP:0007973) | 1.75180772 |
| 125 | Megalencephaly (HP:0001355) | 1.74597288 |
| 126 | Increased circulating renin level (HP:0000848) | 1.72758677 |
| 127 | Lower limb muscle weakness (HP:0007340) | 1.71633725 |
| 128 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.71110733 |
| 129 | Keratoconus (HP:0000563) | 1.71086017 |
| 130 | Increased corneal curvature (HP:0100692) | 1.71086017 |
| 131 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.70787168 |
| 132 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.70787168 |
| 133 | Clumsiness (HP:0002312) | 1.70197021 |
| 134 | Craniofacial dystonia (HP:0012179) | 1.68278922 |
| 135 | Polyuria (HP:0000103) | 1.68180704 |
| 136 | Abnormality of macular pigmentation (HP:0008002) | 1.67952174 |
| 137 | Failure to thrive in infancy (HP:0001531) | 1.67179555 |
| 138 | Neuroendocrine neoplasm (HP:0100634) | 1.65899430 |
| 139 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.65180244 |
| 140 | Hypomagnesemia (HP:0002917) | 1.63613236 |
| 141 | Oligodactyly (hands) (HP:0001180) | 1.63231361 |
| 142 | Male pseudohermaphroditism (HP:0000037) | 1.59921974 |
| 143 | Abnormality of renin-angiotensin system (HP:0000847) | 1.58306714 |
| 144 | Congenital hepatic fibrosis (HP:0002612) | 1.57494949 |
| 145 | Confusion (HP:0001289) | 1.56751046 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FRK | 5.61912515 |
| 2 | NTRK3 | 4.80028979 |
| 3 | EPHA4 | 3.93293602 |
| 4 | MAP3K9 | 3.20124968 |
| 5 | MAP3K4 | 3.08218562 |
| 6 | MAP2K7 | 3.01426100 |
| 7 | MARK1 | 2.87366169 |
| 8 | MAP4K2 | 2.80330040 |
| 9 | MINK1 | 2.34596201 |
| 10 | CASK | 2.27671463 |
| 11 | TNIK | 2.16754679 |
| 12 | NTRK2 | 2.15400647 |
| 13 | RIPK4 | 2.11863229 |
| 14 | DAPK2 | 2.06757209 |
| 15 | PAK6 | 2.02424341 |
| 16 | GRK1 | 2.00282521 |
| 17 | BMPR1B | 1.88789475 |
| 18 | MAP3K12 | 1.82818293 |
| 19 | PRKD3 | 1.82352267 |
| 20 | MAP2K4 | 1.79739441 |
| 21 | FGFR2 | 1.73668210 |
| 22 | MAPK13 | 1.67702632 |
| 23 | PRPF4B | 1.67361211 |
| 24 | CAMKK1 | 1.61278582 |
| 25 | CAMKK2 | 1.58633850 |
| 26 | SIK2 | 1.57959334 |
| 27 | STK38 | 1.49883543 |
| 28 | NTRK1 | 1.45967373 |
| 29 | DAPK1 | 1.45290857 |
| 30 | CDK5 | 1.43357883 |
| 31 | SIK3 | 1.43034216 |
| 32 | KSR2 | 1.39018957 |
| 33 | KSR1 | 1.33100170 |
| 34 | SGK2 | 1.31787195 |
| 35 | PLK2 | 1.30635410 |
| 36 | GRK5 | 1.27579454 |
| 37 | UHMK1 | 1.27427966 |
| 38 | PRKCG | 1.23299085 |
| 39 | SGK494 | 1.21160882 |
| 40 | SGK223 | 1.21160882 |
| 41 | BMPR2 | 1.18992774 |
| 42 | WNK3 | 1.18949475 |
| 43 | MAP3K2 | 1.18526857 |
| 44 | PNCK | 1.16679767 |
| 45 | FES | 1.14497031 |
| 46 | INSRR | 1.09143449 |
| 47 | CAMK2A | 1.06839361 |
| 48 | NUAK1 | 1.05919307 |
| 49 | CDK19 | 1.05476392 |
| 50 | STK39 | 1.02642871 |
| 51 | CAMK1 | 1.01590756 |
| 52 | WNK4 | 0.99370378 |
| 53 | ARAF | 0.96789299 |
| 54 | SGK3 | 0.95816684 |
| 55 | PKN1 | 0.95425167 |
| 56 | PHKG1 | 0.91954597 |
| 57 | PHKG2 | 0.91954597 |
| 58 | MAP3K13 | 0.91259485 |
| 59 | TNK2 | 0.90033761 |
| 60 | CAMK2B | 0.89312726 |
| 61 | PRKCH | 0.87191472 |
| 62 | TAOK3 | 0.86477204 |
| 63 | CSNK1G1 | 0.84453852 |
| 64 | SGK1 | 0.82644150 |
| 65 | STK11 | 0.82223636 |
| 66 | CSNK1G3 | 0.81823676 |
| 67 | TLK1 | 0.81054008 |
| 68 | MARK2 | 0.80995175 |
| 69 | ZAK | 0.80355523 |
| 70 | DYRK1A | 0.80145167 |
| 71 | CAMK1D | 0.78337228 |
| 72 | ACVR1B | 0.76843096 |
| 73 | CDC42BPA | 0.74381192 |
| 74 | PAK3 | 0.73721111 |
| 75 | OXSR1 | 0.72913516 |
| 76 | NEK6 | 0.72690848 |
| 77 | AKT3 | 0.72554106 |
| 78 | WNK1 | 0.71671092 |
| 79 | MAP2K6 | 0.70646309 |
| 80 | CDK18 | 0.70502725 |
| 81 | CAMK1G | 0.70183969 |
| 82 | DYRK2 | 0.69699331 |
| 83 | PINK1 | 0.68320702 |
| 84 | CDK15 | 0.66693109 |
| 85 | MAPKAPK5 | 0.64139044 |
| 86 | CDK14 | 0.63665732 |
| 87 | MAP3K1 | 0.62991169 |
| 88 | CAMK4 | 0.59305846 |
| 89 | ADRBK2 | 0.59207149 |
| 90 | PRKAA1 | 0.59116075 |
| 91 | CSNK1G2 | 0.59053134 |
| 92 | RIPK1 | 0.58849449 |
| 93 | CSNK1A1L | 0.58599687 |
| 94 | CSNK1A1 | 0.58129866 |
| 95 | PRKCE | 0.57532484 |
| 96 | CDK11A | 0.57264135 |
| 97 | RET | 0.56565739 |
| 98 | TAOK1 | 0.56343709 |
| 99 | TYRO3 | 0.56026349 |
| 100 | MAP3K6 | 0.55123367 |
| 101 | CAMK2D | 0.54501789 |
| 102 | ADRBK1 | 0.53602430 |
| 103 | HIPK2 | 0.53584008 |
| 104 | STK38L | 0.53267990 |
| 105 | BRSK2 | 0.52314908 |
| 106 | ALK | 0.51423682 |
| 107 | TIE1 | 0.51035892 |
| 108 | CSNK1D | 0.50702123 |
| 109 | RAF1 | 0.49925469 |
| 110 | RPS6KA3 | 0.48764805 |
| 111 | PDK1 | 0.47063130 |
| 112 | CDK3 | 0.45223599 |
| 113 | LATS2 | 0.45006470 |
| 114 | BRSK1 | 0.44991237 |
| 115 | MAPK10 | 0.43725660 |
| 116 | PRKCA | 0.42712571 |
| 117 | BRAF | 0.42645293 |
| 118 | BCR | 0.42141877 |
| 119 | FYN | 0.40840177 |
| 120 | MUSK | 0.40724229 |
| 121 | PTK2B | 0.40323828 |
| 122 | PRKCZ | 0.39979848 |
| 123 | CAMK2G | 0.39849018 |
| 124 | ERBB3 | 0.38395302 |
| 125 | PRKCB | 0.37561227 |
| 126 | PRKG1 | 0.37323780 |
| 127 | ERBB2 | 0.35782430 |
| 128 | RPS6KA2 | 0.35759286 |
| 129 | PDPK1 | 0.35560044 |
| 130 | PRKACA | 0.35177462 |
| 131 | MKNK2 | 0.33389594 |
| 132 | PLK3 | 0.33054879 |
| 133 | CSNK1E | 0.32481259 |
| 134 | GSK3B | 0.31801461 |
| 135 | MAP2K1 | 0.30693868 |
| 136 | PIK3CA | 0.29430490 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.99049232 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.09950963 |
| 3 | Olfactory transduction_Homo sapiens_hsa04740 | 2.95913482 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.79317375 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.79156618 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.73864676 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.69207026 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.68385756 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.62193494 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.46197563 |
| 11 | Insulin secretion_Homo sapiens_hsa04911 | 2.39553656 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.16017184 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.13263138 |
| 14 | Taste transduction_Homo sapiens_hsa04742 | 2.12514770 |
| 15 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.95467354 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95300776 |
| 17 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.94338864 |
| 18 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.88902719 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.88653264 |
| 20 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.78181690 |
| 21 | Long-term depression_Homo sapiens_hsa04730 | 1.76389303 |
| 22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.74181450 |
| 23 | Renin secretion_Homo sapiens_hsa04924 | 1.71768805 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.71257595 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.64928755 |
| 26 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.54646819 |
| 27 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.47825230 |
| 28 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.46811789 |
| 29 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.45367897 |
| 30 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.38995035 |
| 31 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.34015877 |
| 32 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.32385710 |
| 33 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.31446696 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.30229199 |
| 35 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.30165798 |
| 36 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28391140 |
| 37 | Phototransduction_Homo sapiens_hsa04744 | 1.27176442 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.19277098 |
| 39 | Gap junction_Homo sapiens_hsa04540 | 1.17829016 |
| 40 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.15741215 |
| 41 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.12325544 |
| 42 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.07230964 |
| 43 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.06928809 |
| 44 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.05658856 |
| 45 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.05361605 |
| 46 | Axon guidance_Homo sapiens_hsa04360 | 1.01307835 |
| 47 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.99914124 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.99645335 |
| 49 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.99400803 |
| 50 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.97273915 |
| 51 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.96281917 |
| 52 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.95214127 |
| 53 | ABC transporters_Homo sapiens_hsa02010 | 0.94823539 |
| 54 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93579118 |
| 55 | Glioma_Homo sapiens_hsa05214 | 0.93218922 |
| 56 | Melanogenesis_Homo sapiens_hsa04916 | 0.93119624 |
| 57 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.89503346 |
| 58 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.85951077 |
| 59 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.84199439 |
| 60 | Circadian rhythm_Homo sapiens_hsa04710 | 0.82782440 |
| 61 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.82531990 |
| 62 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.81195945 |
| 63 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.80399254 |
| 64 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.77370045 |
| 65 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.77086756 |
| 66 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.76993451 |
| 67 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.75990600 |
| 68 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.74000349 |
| 69 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.73940432 |
| 70 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.71285842 |
| 71 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71249554 |
| 72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.69574438 |
| 73 | Bile secretion_Homo sapiens_hsa04976 | 0.69376242 |
| 74 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.69277933 |
| 75 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.68777773 |
| 76 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.67577445 |
| 77 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.67317249 |
| 78 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.67262679 |
| 79 | Protein export_Homo sapiens_hsa03060 | 0.65103349 |
| 80 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63129033 |
| 81 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.62758684 |
| 82 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.62327769 |
| 83 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.60062974 |
| 84 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.59576794 |
| 85 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.59343726 |
| 86 | * Ras signaling pathway_Homo sapiens_hsa04014 | 0.58770475 |
| 87 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.55607489 |
| 88 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.53030990 |
| 89 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.52883031 |
| 90 | Alcoholism_Homo sapiens_hsa05034 | 0.52173432 |
| 91 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.51988855 |
| 92 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50564561 |
| 93 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.50517719 |
| 94 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.49580043 |
| 95 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.48814583 |
| 96 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.48337061 |
| 97 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48033102 |
| 98 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.47064385 |
| 99 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.46991742 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.46948407 |
| 101 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.46501886 |
| 102 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.46496148 |
| 103 | Parkinsons disease_Homo sapiens_hsa05012 | 0.45677755 |
| 104 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45357300 |
| 105 | Histidine metabolism_Homo sapiens_hsa00340 | 0.44008023 |
| 106 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42430264 |
| 107 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.41953617 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41882777 |
| 109 | RNA degradation_Homo sapiens_hsa03018 | 0.41546337 |
| 110 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.40986760 |
| 111 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.40950768 |
| 112 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.39878784 |
| 113 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.39396395 |
| 114 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.39310921 |
| 115 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.39244987 |
| 116 | Endometrial cancer_Homo sapiens_hsa05213 | 0.39205239 |
| 117 | Mineral absorption_Homo sapiens_hsa04978 | 0.39179644 |
| 118 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.36797011 |
| 119 | Basal transcription factors_Homo sapiens_hsa03022 | 0.36789475 |
| 120 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36765047 |
| 121 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.36458147 |
| 122 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.36278312 |
| 123 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.34467230 |
| 124 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.33275878 |
| 125 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32711133 |
| 126 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.32345052 |
| 127 | Lysine degradation_Homo sapiens_hsa00310 | 0.32152730 |
| 128 | Endocytosis_Homo sapiens_hsa04144 | 0.31876120 |
| 129 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.30346068 |
| 130 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29587531 |
| 131 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28791090 |
| 132 | Alzheimers disease_Homo sapiens_hsa05010 | 0.28329641 |
| 133 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.27048465 |
| 134 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26218636 |
| 135 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25887342 |
| 136 | Prion diseases_Homo sapiens_hsa05020 | 0.25638699 |
| 137 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.25594045 |

