

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.47854833 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.14723072 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.72721315 |
| 4 | viral transcription (GO:0019083) | 4.58697533 |
| 5 | formation of translation preinitiation complex (GO:0001731) | 4.54438455 |
| 6 | translational termination (GO:0006415) | 4.53616091 |
| 7 | nucleobase biosynthetic process (GO:0046112) | 4.49122944 |
| 8 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.47113695 |
| 9 | purine nucleobase biosynthetic process (GO:0009113) | 4.28903240 |
| 10 | DNA strand elongation (GO:0022616) | 4.25785950 |
| 11 | DNA replication initiation (GO:0006270) | 4.24421839 |
| 12 | translational elongation (GO:0006414) | 4.20130666 |
| 13 | ribosome biogenesis (GO:0042254) | 4.16266179 |
| 14 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.13397920 |
| 15 | ribosomal small subunit biogenesis (GO:0042274) | 4.08382914 |
| 16 | translational initiation (GO:0006413) | 4.04980096 |
| 17 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.02870987 |
| 18 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.94155732 |
| 19 | ribosomal large subunit biogenesis (GO:0042273) | 3.93092395 |
| 20 | DNA unwinding involved in DNA replication (GO:0006268) | 3.86822547 |
| 21 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.85541961 |
| 22 | protein targeting to ER (GO:0045047) | 3.81768408 |
| 23 | cotranslational protein targeting to membrane (GO:0006613) | 3.81572485 |
| 24 | ribosome assembly (GO:0042255) | 3.78613783 |
| 25 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.76641478 |
| 26 | DNA replication checkpoint (GO:0000076) | 3.69734507 |
| 27 | transcription from mitochondrial promoter (GO:0006390) | 3.67900547 |
| 28 | IMP biosynthetic process (GO:0006188) | 3.66437750 |
| 29 | protein localization to endoplasmic reticulum (GO:0070972) | 3.63465538 |
| 30 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.63443194 |
| 31 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.62341566 |
| 32 | folic acid metabolic process (GO:0046655) | 3.61654094 |
| 33 | pseudouridine synthesis (GO:0001522) | 3.58810357 |
| 34 | rRNA processing (GO:0006364) | 3.58211357 |
| 35 | telomere maintenance via recombination (GO:0000722) | 3.57532985 |
| 36 | proteasome assembly (GO:0043248) | 3.56309076 |
| 37 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.54637498 |
| 38 | viral life cycle (GO:0019058) | 3.52474689 |
| 39 | cellular protein complex disassembly (GO:0043624) | 3.51120686 |
| 40 | GDP-mannose metabolic process (GO:0019673) | 3.50049861 |
| 41 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.48419500 |
| 42 | rRNA metabolic process (GO:0016072) | 3.47372964 |
| 43 | spliceosomal snRNP assembly (GO:0000387) | 3.46241685 |
| 44 | mitotic metaphase plate congression (GO:0007080) | 3.40215750 |
| 45 | mitochondrial RNA metabolic process (GO:0000959) | 3.38430353 |
| 46 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.35133029 |
| 47 | rRNA modification (GO:0000154) | 3.34962723 |
| 48 | translation (GO:0006412) | 3.30256383 |
| 49 | mitotic nuclear envelope disassembly (GO:0007077) | 3.28159882 |
| 50 | protein localization to kinetochore (GO:0034501) | 3.27288783 |
| 51 | protein targeting to mitochondrion (GO:0006626) | 3.26721124 |
| 52 | IMP metabolic process (GO:0046040) | 3.26219498 |
| 53 | mitotic recombination (GO:0006312) | 3.26140003 |
| 54 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.23833404 |
| 55 | telomere maintenance via telomere lengthening (GO:0010833) | 3.22261644 |
| 56 | protein complex disassembly (GO:0043241) | 3.16420760 |
| 57 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.15636036 |
| 58 | termination of RNA polymerase III transcription (GO:0006386) | 3.15636036 |
| 59 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.14523971 |
| 60 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.12236482 |
| 61 | base-excision repair, AP site formation (GO:0006285) | 3.11730398 |
| 62 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.10102138 |
| 63 | cellular component biogenesis (GO:0044085) | 3.07559079 |
| 64 | NIK/NF-kappaB signaling (GO:0038061) | 3.06121597 |
| 65 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.05112493 |
| 66 | CENP-A containing nucleosome assembly (GO:0034080) | 3.04451137 |
| 67 | chaperone-mediated protein transport (GO:0072321) | 3.04176150 |
| 68 | nuclear envelope disassembly (GO:0051081) | 3.02612622 |
| 69 | membrane disassembly (GO:0030397) | 3.02612622 |
| 70 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.02603450 |
| 71 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01619911 |
| 72 | macromolecular complex disassembly (GO:0032984) | 2.99648682 |
| 73 | protein localization to chromosome, centromeric region (GO:0071459) | 2.98205422 |
| 74 | iron-sulfur cluster assembly (GO:0016226) | 2.96349532 |
| 75 | metallo-sulfur cluster assembly (GO:0031163) | 2.96349532 |
| 76 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.96249767 |
| 77 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.96249767 |
| 78 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.95395130 |
| 79 | negative regulation of ligase activity (GO:0051352) | 2.95395130 |
| 80 | regulation of RIG-I signaling pathway (GO:0039535) | 2.94127381 |
| 81 | chromatin remodeling at centromere (GO:0031055) | 2.93690077 |
| 82 | DNA replication-independent nucleosome organization (GO:0034724) | 2.92819615 |
| 83 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.92819615 |
| 84 | regulation of spindle organization (GO:0090224) | 2.90017912 |
| 85 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.88918619 |
| 86 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.88869729 |
| 87 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.88435576 |
| 88 | cell cycle G1/S phase transition (GO:0044843) | 2.88435576 |
| 89 | deoxyribonucleotide catabolic process (GO:0009264) | 2.88265199 |
| 90 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.88232470 |
| 91 | pteridine-containing compound biosynthetic process (GO:0042559) | 2.87356169 |
| 92 | mRNA catabolic process (GO:0006402) | 2.86864758 |
| 93 | RNA catabolic process (GO:0006401) | 2.86480836 |
| 94 | purine nucleotide salvage (GO:0032261) | 2.85505495 |
| 95 | deoxyribose phosphate catabolic process (GO:0046386) | 2.85454761 |
| 96 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.83764338 |
| 97 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.83764338 |
| 98 | RNA methylation (GO:0001510) | 2.80342370 |
| 99 | metaphase plate congression (GO:0051310) | 2.80057288 |
| 100 | mitochondrial fusion (GO:0008053) | 2.79445029 |
| 101 | regulation of mitochondrial translation (GO:0070129) | 2.77422389 |
| 102 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 2.77025362 |
| 103 | pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130) | 2.76830422 |
| 104 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.75224915 |
| 105 | protein localization to mitochondrion (GO:0070585) | 2.75110019 |
| 106 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.73682941 |
| 107 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.73632807 |
| 108 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.73632807 |
| 109 | negative regulation of RNA splicing (GO:0033119) | 2.72926179 |
| 110 | ncRNA processing (GO:0034470) | 2.72612165 |
| 111 | viral mRNA export from host cell nucleus (GO:0046784) | 2.71856050 |
| 112 | termination of RNA polymerase I transcription (GO:0006363) | 2.70926729 |
| 113 | rRNA methylation (GO:0031167) | 2.70914287 |
| 114 | protein maturation by protein folding (GO:0022417) | 2.69268124 |
| 115 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.69133702 |
| 116 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.68776508 |
| 117 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.68076956 |
| 118 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.68076956 |
| 119 | positive regulation of ligase activity (GO:0051351) | 2.66776298 |
| 120 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.66522337 |
| 121 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.66522337 |
| 122 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.66522337 |
| 123 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.65645245 |
| 124 | mRNA splicing, via spliceosome (GO:0000398) | 2.65643691 |
| 125 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.65643691 |
| 126 | RNA splicing, via transesterification reactions (GO:0000375) | 2.65256814 |
| 127 | ncRNA metabolic process (GO:0034660) | 2.65253492 |
| 128 | tRNA methylation (GO:0030488) | 2.65199300 |
| 129 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.64582686 |
| 130 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.64582686 |
| 131 | regulation of translational termination (GO:0006449) | 2.63984052 |
| 132 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.63941567 |
| 133 | pyrimidine nucleoside monophosphate metabolic process (GO:0009129) | 2.63925398 |
| 134 | nucleotide salvage (GO:0043173) | 2.63659929 |
| 135 | transcription from RNA polymerase I promoter (GO:0006360) | 2.63606956 |
| 136 | tRNA modification (GO:0006400) | 2.62573978 |
| 137 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 2.61536009 |
| 138 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.60825517 |
| 139 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.57590487 |
| 140 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.56251047 |
| 141 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.55685521 |
| 142 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.54035294 |
| 143 | tRNA processing (GO:0008033) | 2.52738740 |
| 144 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 2.52735304 |
| 145 | negative regulation of B cell apoptotic process (GO:0002903) | 2.52013073 |
| 146 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.51467180 |
| 147 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.49735783 |
| 148 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.49411542 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.46315852 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.24845177 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.17458441 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.02151544 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.95528359 |
| 6 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.94727724 |
| 7 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.88865811 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.88337779 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.80132063 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.79985799 |
| 11 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.75125364 |
| 12 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.70200587 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.67520078 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.62133123 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.46409684 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.36709125 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.27684974 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.24954345 |
| 19 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.15421606 |
| 20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.14241013 |
| 21 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.06891962 |
| 22 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.06765644 |
| 23 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.02694396 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.99619605 |
| 25 | MYC_22102868_ChIP-Seq_BL_Human | 1.99209293 |
| 26 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.97709259 |
| 27 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.94654902 |
| 28 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90959283 |
| 29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.88964125 |
| 30 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.86178092 |
| 31 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.72442873 |
| 32 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.70668035 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.68645116 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.68070197 |
| 35 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.67771716 |
| 36 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.67516033 |
| 37 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.66331433 |
| 38 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.66016427 |
| 39 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.65065328 |
| 40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.62523611 |
| 41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.62271904 |
| 42 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.59838294 |
| 43 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.58481637 |
| 44 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56210539 |
| 45 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52116100 |
| 46 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.52029846 |
| 47 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.50285020 |
| 48 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.49506958 |
| 49 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.48744051 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.46348111 |
| 51 | * NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.46226008 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.46203646 |
| 53 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.45669357 |
| 54 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.43332210 |
| 55 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.42455199 |
| 56 | * VDR_21846776_ChIP-Seq_THP-1_Human | 1.40592122 |
| 57 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.38715909 |
| 58 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.33992814 |
| 59 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27705704 |
| 60 | * MAF_26560356_Chip-Seq_TH2_Human | 1.26071476 |
| 61 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.25449059 |
| 62 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25306088 |
| 63 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.24250951 |
| 64 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.22910122 |
| 65 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.22150758 |
| 66 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.21428185 |
| 67 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.17450442 |
| 68 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.15503744 |
| 69 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.14298959 |
| 70 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.14207587 |
| 71 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.13731124 |
| 72 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11072027 |
| 73 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.10490299 |
| 74 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10281534 |
| 75 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.10192062 |
| 76 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.09945597 |
| 77 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.07066173 |
| 78 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.06620517 |
| 79 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.04920695 |
| 80 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.03447197 |
| 81 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.01164583 |
| 82 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.00412533 |
| 83 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.99025347 |
| 84 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.98726026 |
| 85 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.97826574 |
| 86 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.97826398 |
| 87 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.96640867 |
| 88 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.96146822 |
| 89 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.95354583 |
| 90 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.93657230 |
| 91 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93436044 |
| 92 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.92628496 |
| 93 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.92546489 |
| 94 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.92497861 |
| 95 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.91841506 |
| 96 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.91687413 |
| 97 | MYB_26560356_Chip-Seq_TH2_Human | 0.91653981 |
| 98 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.91524464 |
| 99 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.90936492 |
| 100 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90787797 |
| 101 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.90469447 |
| 102 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.89507918 |
| 103 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.86021234 |
| 104 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.85560716 |
| 105 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84822818 |
| 106 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.84699806 |
| 107 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.83558340 |
| 108 | MAF_26560356_Chip-Seq_TH1_Human | 0.83395592 |
| 109 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.82883716 |
| 110 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 0.82352830 |
| 111 | UTX_26944678_Chip-Seq_JUKART_Human | 0.82191924 |
| 112 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.82188010 |
| 113 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82094722 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.41445424 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.11890811 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.58542624 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.50128679 |
| 5 | MP0003077_abnormal_cell_cycle | 3.40519015 |
| 6 | MP0008057_abnormal_DNA_replication | 3.11346941 |
| 7 | MP0002396_abnormal_hematopoietic_system | 2.88975454 |
| 8 | MP0008058_abnormal_DNA_repair | 2.56989220 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.36674190 |
| 10 | MP0003806_abnormal_nucleotide_metabolis | 2.22761921 |
| 11 | MP0001730_embryonic_growth_arrest | 2.11026351 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.07830198 |
| 13 | MP0005397_hematopoietic_system_phenotyp | 2.07253473 |
| 14 | MP0001545_abnormal_hematopoietic_system | 2.07253473 |
| 15 | MP0000490_abnormal_crypts_of | 2.00531925 |
| 16 | MP0008932_abnormal_embryonic_tissue | 2.00367727 |
| 17 | MP0005058_abnormal_lysosome_morphology | 1.96939565 |
| 18 | MP0003763_abnormal_thymus_physiology | 1.95124996 |
| 19 | MP0010352_gastrointestinal_tract_polyps | 1.90159551 |
| 20 | MP0004808_abnormal_hematopoietic_stem | 1.85192651 |
| 21 | MP0000350_abnormal_cell_proliferation | 1.84413828 |
| 22 | MP0006054_spinal_hemorrhage | 1.80126140 |
| 23 | MP0003786_premature_aging | 1.67497128 |
| 24 | MP0008260_abnormal_autophagy | 1.60280114 |
| 25 | MP0001661_extended_life_span | 1.57470272 |
| 26 | MP0002398_abnormal_bone_marrow | 1.52504510 |
| 27 | MP0001853_heart_inflammation | 1.51505192 |
| 28 | MP0002019_abnormal_tumor_incidence | 1.50915397 |
| 29 | MP0003123_paternal_imprinting | 1.48428344 |
| 30 | MP0003718_maternal_effect | 1.47275309 |
| 31 | MP0003656_abnormal_erythrocyte_physiolo | 1.46819021 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 1.45104336 |
| 33 | MP0002722_abnormal_immune_system | 1.44388377 |
| 34 | MP0002080_prenatal_lethality | 1.43682527 |
| 35 | MP0009840_abnormal_foam_cell | 1.42731185 |
| 36 | MP0001697_abnormal_embryo_size | 1.42447489 |
| 37 | MP0010307_abnormal_tumor_latency | 1.42426992 |
| 38 | MP0001790_abnormal_immune_system | 1.41031972 |
| 39 | MP0005387_immune_system_phenotype | 1.41031972 |
| 40 | MP0000685_abnormal_immune_system | 1.40823412 |
| 41 | MP0000313_abnormal_cell_death | 1.40576526 |
| 42 | MP0003303_peritoneal_inflammation | 1.40016207 |
| 43 | MP0000689_abnormal_spleen_morphology | 1.39959847 |
| 44 | MP0006036_abnormal_mitochondrial_physio | 1.38558007 |
| 45 | MP0005380_embryogenesis_phenotype | 1.38182119 |
| 46 | MP0001672_abnormal_embryogenesis/_devel | 1.38182119 |
| 47 | MP0003186_abnormal_redox_activity | 1.36778598 |
| 48 | MP0000703_abnormal_thymus_morphology | 1.36052216 |
| 49 | MP0003984_embryonic_growth_retardation | 1.32840288 |
| 50 | MP0003567_abnormal_fetal_cardiomyocyte | 1.29759710 |
| 51 | MP0002088_abnormal_embryonic_growth/wei | 1.29267210 |
| 52 | MP0003221_abnormal_cardiomyocyte_apopto | 1.29221800 |
| 53 | MP0002429_abnormal_blood_cell | 1.21687113 |
| 54 | MP0000358_abnormal_cell_content/ | 1.19073155 |
| 55 | MP0002160_abnormal_reproductive_system | 1.16970707 |
| 56 | MP0000858_altered_metastatic_potential | 1.15413294 |
| 57 | MP0009278_abnormal_bone_marrow | 1.11935196 |
| 58 | MP0003436_decreased_susceptibility_to | 1.11711007 |
| 59 | MP0000716_abnormal_immune_system | 1.11433950 |
| 60 | MP0002086_abnormal_extraembryonic_tissu | 1.11377489 |
| 61 | MP0002419_abnormal_innate_immunity | 1.10426208 |
| 62 | MP0001542_abnormal_bone_strength | 1.10254911 |
| 63 | MP0002132_abnormal_respiratory_system | 1.09711398 |
| 64 | MP0004147_increased_porphyrin_level | 1.08920363 |
| 65 | MP0000015_abnormal_ear_pigmentation | 1.08264389 |
| 66 | MP0004947_skin_inflammation | 1.07596008 |
| 67 | MP0005501_abnormal_skin_physiology | 1.06216942 |
| 68 | MP0000465_gastrointestinal_hemorrhage | 1.02746025 |
| 69 | MP0001835_abnormal_antigen_presentation | 1.02369641 |
| 70 | MP0008995_early_reproductive_senescence | 1.02286450 |
| 71 | MP0001919_abnormal_reproductive_system | 1.01663198 |
| 72 | MP0006035_abnormal_mitochondrial_morpho | 1.01569052 |
| 73 | MP0001800_abnormal_humoral_immune | 1.01077823 |
| 74 | MP0002085_abnormal_embryonic_tissue | 1.00312094 |
| 75 | MP0008877_abnormal_DNA_methylation | 0.99218584 |
| 76 | MP0005671_abnormal_response_to | 0.98736523 |
| 77 | MP0005310_abnormal_salivary_gland | 0.98226320 |
| 78 | MP0002420_abnormal_adaptive_immunity | 0.94493950 |
| 79 | MP0002166_altered_tumor_susceptibility | 0.94383402 |
| 80 | MP0002405_respiratory_system_inflammati | 0.93693077 |
| 81 | MP0005389_reproductive_system_phenotype | 0.93183733 |
| 82 | MP0001819_abnormal_immune_cell | 0.92610774 |
| 83 | MP0004197_abnormal_fetal_growth/weight/ | 0.91973187 |
| 84 | MP0009697_abnormal_copulation | 0.91784926 |
| 85 | MP0002723_abnormal_immune_serum | 0.91239438 |
| 86 | MP0001873_stomach_inflammation | 0.89502646 |
| 87 | MP0002452_abnormal_antigen_presenting | 0.87811495 |
| 88 | MP0009785_altered_susceptibility_to | 0.87716327 |
| 89 | MP0005075_abnormal_melanosome_morpholog | 0.86402810 |
| 90 | MP0003453_abnormal_keratinocyte_physiol | 0.86175837 |
| 91 | MP0000598_abnormal_liver_morphology | 0.85906731 |
| 92 | MP0002877_abnormal_melanocyte_morpholog | 0.84478305 |
| 93 | MP0004782_abnormal_surfactant_physiolog | 0.84318474 |
| 94 | MP0010155_abnormal_intestine_physiology | 0.83295132 |
| 95 | MP0002084_abnormal_developmental_patter | 0.82930825 |
| 96 | MP0005025_abnormal_response_to | 0.82363150 |
| 97 | MP0001727_abnormal_embryo_implantation | 0.79982465 |
| 98 | MP0009672_abnormal_birth_weight | 0.79239879 |
| 99 | MP0005451_abnormal_body_composition | 0.77296823 |
| 100 | MP0005220_abnormal_exocrine_pancreas | 0.77074903 |
| 101 | MP0005330_cardiomyopathy | 0.76111929 |
| 102 | MP0003191_abnormal_cellular_cholesterol | 0.75652111 |
| 103 | MP0000477_abnormal_intestine_morphology | 0.75041360 |
| 104 | MP0001764_abnormal_homeostasis | 0.74844295 |
| 105 | MP0000750_abnormal_muscle_regeneration | 0.74500403 |
| 106 | MP0003448_altered_tumor_morphology | 0.73745295 |
| 107 | MP0005000_abnormal_immune_tolerance | 0.73276916 |
| 108 | MP0002006_tumorigenesis | 0.72073251 |
| 109 | MP0005384_cellular_phenotype | 0.71734440 |
| 110 | MP0005464_abnormal_platelet_physiology | 0.69748929 |
| 111 | MP0000609_abnormal_liver_physiology | 0.69667234 |
| 112 | MP0001929_abnormal_gametogenesis | 0.69219198 |
| 113 | MP0001845_abnormal_inflammatory_respons | 0.67934087 |
| 114 | MP0005621_abnormal_cell_physiology | 0.67391530 |
| 115 | MP0009764_decreased_sensitivity_to | 0.67148919 |
| 116 | MP0008469_abnormal_protein_level | 0.66797197 |
| 117 | MP0003866_abnormal_defecation | 0.66074496 |
| 118 | MP0003705_abnormal_hypodermis_morpholog | 0.65975945 |
| 119 | MP0005266_abnormal_metabolism | 0.65971922 |
| 120 | MP0002210_abnormal_sex_determination | 0.64410524 |
| 121 | MP0001145_abnormal_male_reproductive | 0.63410905 |
| 122 | MP0005023_abnormal_wound_healing | 0.63277411 |
| 123 | MP0001293_anophthalmia | 0.63251594 |
| 124 | MP0005319_abnormal_enzyme/_coenzyme | 0.62799778 |
| 125 | MP0003724_increased_susceptibility_to | 0.60705754 |
| 126 | MP0010030_abnormal_orbit_morphology | 0.59060744 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.64759314 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.54782865 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.84722707 |
| 4 | Reticulocytopenia (HP:0001896) | 4.39129377 |
| 5 | Increased hepatocellular lipid droplets (HP:0006565) | 3.87756447 |
| 6 | Aplastic anemia (HP:0001915) | 3.75064029 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 3.73945796 |
| 8 | Increased intramyocellular lipid droplets (HP:0012240) | 3.65885107 |
| 9 | Oral leukoplakia (HP:0002745) | 3.65239671 |
| 10 | Breast hypoplasia (HP:0003187) | 3.55025202 |
| 11 | Thrombocytosis (HP:0001894) | 3.51933001 |
| 12 | Multiple enchondromatosis (HP:0005701) | 3.51492652 |
| 13 | Microretrognathia (HP:0000308) | 3.49131034 |
| 14 | Macrocytic anemia (HP:0001972) | 3.45398519 |
| 15 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.37070784 |
| 16 | Increased muscle lipid content (HP:0009058) | 3.35810749 |
| 17 | Mitochondrial inheritance (HP:0001427) | 3.34010052 |
| 18 | Increased CSF lactate (HP:0002490) | 3.32454685 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.31645635 |
| 20 | Pallor (HP:0000980) | 3.25571562 |
| 21 | Testicular atrophy (HP:0000029) | 3.23646086 |
| 22 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.08969127 |
| 23 | Rough bone trabeculation (HP:0100670) | 2.99402611 |
| 24 | Progressive muscle weakness (HP:0003323) | 2.89227925 |
| 25 | Acute necrotizing encephalopathy (HP:0006965) | 2.88558508 |
| 26 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.87427999 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.87427999 |
| 28 | Cerebral hypomyelination (HP:0006808) | 2.87170752 |
| 29 | IgM deficiency (HP:0002850) | 2.85844765 |
| 30 | Colon cancer (HP:0003003) | 2.83249356 |
| 31 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.80301687 |
| 32 | Abnormality of the anterior horn cell (HP:0006802) | 2.78512310 |
| 33 | Degeneration of anterior horn cells (HP:0002398) | 2.78512310 |
| 34 | Trismus (HP:0000211) | 2.76979101 |
| 35 | Selective tooth agenesis (HP:0001592) | 2.70748518 |
| 36 | Acute encephalopathy (HP:0006846) | 2.70055635 |
| 37 | Panhypogammaglobulinemia (HP:0003139) | 2.66348191 |
| 38 | Lactic acidosis (HP:0003128) | 2.60428972 |
| 39 | B lymphocytopenia (HP:0010976) | 2.57477562 |
| 40 | Carpal bone hypoplasia (HP:0001498) | 2.53333525 |
| 41 | Patellar aplasia (HP:0006443) | 2.50868819 |
| 42 | Hypertensive crisis (HP:0100735) | 2.43599413 |
| 43 | Petechiae (HP:0000967) | 2.41773193 |
| 44 | Severe combined immunodeficiency (HP:0004430) | 2.39291029 |
| 45 | Secondary amenorrhea (HP:0000869) | 2.36900289 |
| 46 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.36097617 |
| 47 | Abnormality of reticulocytes (HP:0004312) | 2.34756244 |
| 48 | Exercise intolerance (HP:0003546) | 2.34662202 |
| 49 | Pancytopenia (HP:0001876) | 2.34035636 |
| 50 | IgG deficiency (HP:0004315) | 2.32332954 |
| 51 | Increased serum pyruvate (HP:0003542) | 2.31927253 |
| 52 | Muscle fiber atrophy (HP:0100295) | 2.30785115 |
| 53 | Premature ovarian failure (HP:0008209) | 2.30592757 |
| 54 | Progressive microcephaly (HP:0000253) | 2.27057843 |
| 55 | Increased serum lactate (HP:0002151) | 2.25722588 |
| 56 | Recurrent viral infections (HP:0004429) | 2.25137710 |
| 57 | Myelodysplasia (HP:0002863) | 2.24827152 |
| 58 | Combined immunodeficiency (HP:0005387) | 2.23066365 |
| 59 | Entropion (HP:0000621) | 2.22376444 |
| 60 | Absent thumb (HP:0009777) | 2.20390351 |
| 61 | Neoplasm of the pancreas (HP:0002894) | 2.19396032 |
| 62 | Abnormality of glycolysis (HP:0004366) | 2.17867988 |
| 63 | Hypergonadotropic hypogonadism (HP:0000815) | 2.16937360 |
| 64 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.16630104 |
| 65 | Abnormality of alanine metabolism (HP:0010916) | 2.16630104 |
| 66 | Hyperalaninemia (HP:0003348) | 2.16630104 |
| 67 | Premature graying of hair (HP:0002216) | 2.16492395 |
| 68 | Reduced antithrombin III activity (HP:0001976) | 2.14325389 |
| 69 | Abnormality of T cell physiology (HP:0011840) | 2.14079869 |
| 70 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.13383426 |
| 71 | Abnormality of B cell number (HP:0010975) | 2.11749014 |
| 72 | Type 2 muscle fiber atrophy (HP:0003554) | 2.11450565 |
| 73 | Microvesicular hepatic steatosis (HP:0001414) | 2.10447671 |
| 74 | Slender long bone (HP:0003100) | 2.10225757 |
| 75 | Poor head control (HP:0002421) | 2.08814490 |
| 76 | Abnormality of DNA repair (HP:0003254) | 2.08361006 |
| 77 | Abnormal trabecular bone morphology (HP:0100671) | 2.07174251 |
| 78 | Agammaglobulinemia (HP:0004432) | 2.05588412 |
| 79 | Abnormality of the preputium (HP:0100587) | 2.05382670 |
| 80 | Cellular immunodeficiency (HP:0005374) | 2.05061717 |
| 81 | Megaloblastic anemia (HP:0001889) | 2.04209701 |
| 82 | Progressive macrocephaly (HP:0004481) | 2.03234719 |
| 83 | Increased serum ferritin (HP:0003281) | 2.02559403 |
| 84 | Opisthotonus (HP:0002179) | 2.02246921 |
| 85 | Lymphoma (HP:0002665) | 2.02143481 |
| 86 | Bone marrow hypocellularity (HP:0005528) | 2.01953566 |
| 87 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.01488506 |
| 88 | Basal cell carcinoma (HP:0002671) | 2.00731865 |
| 89 | Abnormality of T cells (HP:0002843) | 2.00219605 |
| 90 | Sparse eyelashes (HP:0000653) | 1.99436946 |
| 91 | Abnormality of the costochondral junction (HP:0000919) | 1.98986324 |
| 92 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.97815463 |
| 93 | Rhabdomyolysis (HP:0003201) | 1.97770904 |
| 94 | Type I transferrin isoform profile (HP:0003642) | 1.97321779 |
| 95 | Poikiloderma (HP:0001029) | 1.96673600 |
| 96 | CNS hypomyelination (HP:0003429) | 1.96562154 |
| 97 | 11 pairs of ribs (HP:0000878) | 1.95144978 |
| 98 | Ureteral duplication (HP:0000073) | 1.94855799 |
| 99 | IgA deficiency (HP:0002720) | 1.93835228 |
| 100 | Dyschromatopsia (HP:0007641) | 1.93615014 |
| 101 | Cerebral edema (HP:0002181) | 1.92233642 |
| 102 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.87340059 |
| 103 | Abnormality of lateral ventricle (HP:0030047) | 1.87307619 |
| 104 | Hepatic necrosis (HP:0002605) | 1.87087078 |
| 105 | Abnormality of chromosome stability (HP:0003220) | 1.86675449 |
| 106 | Recurrent fungal infections (HP:0002841) | 1.86299384 |
| 107 | Glossoptosis (HP:0000162) | 1.85354484 |
| 108 | Hepatosplenomegaly (HP:0001433) | 1.85269700 |
| 109 | Nausea (HP:0002018) | 1.85240641 |
| 110 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.84707728 |
| 111 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.84707728 |
| 112 | Abnormal protein glycosylation (HP:0012346) | 1.84707728 |
| 113 | Abnormal glycosylation (HP:0012345) | 1.84707728 |
| 114 | Obstructive lung disease (HP:0006536) | 1.84362975 |
| 115 | Chronic obstructive pulmonary disease (HP:0006510) | 1.84362975 |
| 116 | Meckel diverticulum (HP:0002245) | 1.84086601 |
| 117 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.83436294 |
| 118 | Increased IgM level (HP:0003496) | 1.81655705 |
| 119 | Granulocytopenia (HP:0001913) | 1.81297533 |
| 120 | Seborrheic dermatitis (HP:0001051) | 1.81108060 |
| 121 | Reduced subcutaneous adipose tissue (HP:0003758) | 1.80397640 |
| 122 | Squamous cell carcinoma (HP:0002860) | 1.79790697 |
| 123 | Abnormality of the pons (HP:0007361) | 1.79647545 |
| 124 | Polycythemia (HP:0001901) | 1.78555702 |
| 125 | Hypoplasia of the pons (HP:0012110) | 1.78244502 |
| 126 | Medulloblastoma (HP:0002885) | 1.77348185 |
| 127 | Exertional dyspnea (HP:0002875) | 1.77280235 |
| 128 | Neutropenia (HP:0001875) | 1.77173523 |
| 129 | Abnormality of iron homeostasis (HP:0011031) | 1.76961912 |
| 130 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.76944804 |
| 131 | Single umbilical artery (HP:0001195) | 1.76944804 |
| 132 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.76944804 |
| 133 | Gastrointestinal stroma tumor (HP:0100723) | 1.76330622 |
| 134 | Mediastinal lymphadenopathy (HP:0100721) | 1.76126537 |
| 135 | Lymphopenia (HP:0001888) | 1.75573154 |
| 136 | Abnormality of the ileum (HP:0001549) | 1.75496693 |
| 137 | Hepatocellular necrosis (HP:0001404) | 1.74269680 |
| 138 | Dicarboxylic aciduria (HP:0003215) | 1.74026643 |
| 139 | Abnormality of the umbilical cord (HP:0010881) | 1.73278558 |
| 140 | Pustule (HP:0200039) | 1.72562756 |
| 141 | Respiratory difficulties (HP:0002880) | 1.72453047 |
| 142 | Overlapping toe (HP:0001845) | 1.72135380 |
| 143 | Death in infancy (HP:0001522) | 1.70851770 |
| 144 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.70624100 |
| 145 | Amaurosis fugax (HP:0100576) | 1.70514152 |
| 146 | Prominent nose (HP:0000448) | 1.70456741 |
| 147 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.70419640 |
| 148 | Cleft eyelid (HP:0000625) | 1.69864676 |
| 149 | Microcytic anemia (HP:0001935) | 1.68618322 |
| 150 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.67810392 |
| 151 | Impulsivity (HP:0100710) | 1.67343046 |
| 152 | Ragged-red muscle fibers (HP:0003200) | 1.65836210 |
| 153 | Chronic otitis media (HP:0000389) | 1.64760335 |
| 154 | Areflexia of lower limbs (HP:0002522) | 1.61569044 |
| 155 | Hyperglycinemia (HP:0002154) | 1.60789976 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.41867943 |
| 2 | WEE1 | 3.73906846 |
| 3 | NME2 | 3.69342442 |
| 4 | EIF2AK1 | 3.22829592 |
| 5 | VRK2 | 3.06064653 |
| 6 | CDC7 | 2.61395684 |
| 7 | STK16 | 2.55197324 |
| 8 | ACVR1B | 2.35321434 |
| 9 | NEK2 | 2.35199299 |
| 10 | TESK2 | 2.26524114 |
| 11 | RPS6KA4 | 2.21829605 |
| 12 | PBK | 2.20069749 |
| 13 | DYRK3 | 2.04045282 |
| 14 | KDR | 2.02974208 |
| 15 | PIM2 | 2.02294053 |
| 16 | MAP4K1 | 1.98153984 |
| 17 | EIF2AK3 | 1.94765684 |
| 18 | BCKDK | 1.92129948 |
| 19 | EEF2K | 1.91601406 |
| 20 | BRSK2 | 1.87121198 |
| 21 | TSSK6 | 1.77971144 |
| 22 | SCYL2 | 1.70482918 |
| 23 | SMG1 | 1.63621966 |
| 24 | MAP2K3 | 1.61200483 |
| 25 | SRPK1 | 1.57118366 |
| 26 | RPS6KB2 | 1.52610873 |
| 27 | VRK1 | 1.50845422 |
| 28 | MAP3K11 | 1.48092042 |
| 29 | PRPF4B | 1.47902994 |
| 30 | CDK7 | 1.45802875 |
| 31 | CDK4 | 1.37803850 |
| 32 | TTK | 1.37368253 |
| 33 | PASK | 1.37030237 |
| 34 | PLK1 | 1.35569197 |
| 35 | PLK4 | 1.35548460 |
| 36 | ERN1 | 1.34576768 |
| 37 | AURKB | 1.33568736 |
| 38 | TGFBR1 | 1.33400839 |
| 39 | MAP3K10 | 1.32685304 |
| 40 | PDK2 | 1.30993163 |
| 41 | MAP3K8 | 1.30750424 |
| 42 | NEK1 | 1.29420792 |
| 43 | MAP4K2 | 1.22999184 |
| 44 | ARAF | 1.22722333 |
| 45 | ZAP70 | 1.19256294 |
| 46 | FLT3 | 1.18101470 |
| 47 | STK10 | 1.17996198 |
| 48 | TRIB3 | 1.15225494 |
| 49 | MAPKAPK3 | 1.14946009 |
| 50 | ATR | 1.14121428 |
| 51 | PKN2 | 1.12264546 |
| 52 | BRSK1 | 1.07262713 |
| 53 | PAK4 | 1.06330176 |
| 54 | IRAK4 | 1.03451021 |
| 55 | LRRK2 | 1.02501000 |
| 56 | DAPK1 | 1.01728489 |
| 57 | MKNK1 | 0.98484076 |
| 58 | NUAK1 | 0.98032718 |
| 59 | IKBKE | 0.97868695 |
| 60 | AURKA | 0.97548939 |
| 61 | MAP3K14 | 0.97545992 |
| 62 | MAP3K3 | 0.95960897 |
| 63 | CHEK2 | 0.95131813 |
| 64 | NME1 | 0.92206075 |
| 65 | CDK8 | 0.91866218 |
| 66 | JAK3 | 0.91198899 |
| 67 | BTK | 0.89634156 |
| 68 | PIM1 | 0.89238826 |
| 69 | CSNK1G3 | 0.84257029 |
| 70 | CLK1 | 0.83297601 |
| 71 | EIF2AK2 | 0.78458059 |
| 72 | TYK2 | 0.77967522 |
| 73 | DAPK3 | 0.77284748 |
| 74 | TRIM28 | 0.77068969 |
| 75 | TEC | 0.76903772 |
| 76 | TAF1 | 0.75246207 |
| 77 | FES | 0.75208438 |
| 78 | CHEK1 | 0.72781680 |
| 79 | TAOK2 | 0.71397298 |
| 80 | TLK1 | 0.70103228 |
| 81 | MAPK15 | 0.69361417 |
| 82 | MKNK2 | 0.66806101 |
| 83 | MATK | 0.65953798 |
| 84 | BLK | 0.64358640 |
| 85 | CCNB1 | 0.64161563 |
| 86 | RAF1 | 0.62094407 |
| 87 | CSNK2A2 | 0.61989931 |
| 88 | EPHA2 | 0.61917760 |
| 89 | ILK | 0.61904703 |
| 90 | BRAF | 0.60137640 |
| 91 | PAK1 | 0.59652404 |
| 92 | STK4 | 0.59570988 |
| 93 | CSNK1A1L | 0.58965777 |
| 94 | KIT | 0.58595328 |
| 95 | IRAK2 | 0.58595322 |
| 96 | GRK6 | 0.58197996 |
| 97 | MARK3 | 0.58180876 |
| 98 | RPS6KA5 | 0.56980811 |
| 99 | CSNK2A1 | 0.56217805 |
| 100 | MAP3K1 | 0.55825745 |
| 101 | MAPK11 | 0.55527984 |
| 102 | PLK3 | 0.54376262 |
| 103 | MAP2K2 | 0.53103076 |
| 104 | CDK2 | 0.52873974 |
| 105 | RIPK4 | 0.52576608 |
| 106 | NLK | 0.51722965 |
| 107 | MAP3K5 | 0.50092699 |
| 108 | ABL2 | 0.49751085 |
| 109 | TESK1 | 0.49663415 |
| 110 | IKBKB | 0.47553573 |
| 111 | TBK1 | 0.47309275 |
| 112 | CDK12 | 0.46150028 |
| 113 | MAP2K7 | 0.46004307 |
| 114 | CSNK1G1 | 0.45121720 |
| 115 | CSNK1G2 | 0.42953273 |
| 116 | TAOK1 | 0.41115475 |
| 117 | ATM | 0.40511641 |
| 118 | IRAK3 | 0.39750360 |
| 119 | CDK6 | 0.37752849 |
| 120 | ALK | 0.37078036 |
| 121 | TXK | 0.37070144 |
| 122 | PAK2 | 0.34460661 |
| 123 | ZAK | 0.33886767 |
| 124 | CSF1R | 0.33705089 |
| 125 | CDK19 | 0.32620729 |
| 126 | TIE1 | 0.31172503 |
| 127 | SYK | 0.31033689 |
| 128 | AKT2 | 0.30557165 |
| 129 | LYN | 0.29228177 |
| 130 | MAPKAPK2 | 0.27465166 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.62174154 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.04448443 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.53736869 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.48281573 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.45688413 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 3.42074673 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.98710815 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.76075574 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.70897013 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.69651067 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.48551355 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.29198779 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.20145237 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.19733538 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.15852288 |
| 16 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.74655863 |
| 17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.68475670 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.57269597 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.57031475 |
| 20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.54173016 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.45292433 |
| 22 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.39447249 |
| 23 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.37635399 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.35444331 |
| 25 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.32917475 |
| 26 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.32668178 |
| 27 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.30536320 |
| 28 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.24965110 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.24178005 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.15148545 |
| 31 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.12992316 |
| 32 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.12918967 |
| 33 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.09066294 |
| 34 | Protein export_Homo sapiens_hsa03060 | 1.08176231 |
| 35 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.07914336 |
| 36 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.04934945 |
| 37 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.04303440 |
| 38 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.97620709 |
| 39 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.95661521 |
| 40 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.93342461 |
| 41 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.92952893 |
| 42 | Allograft rejection_Homo sapiens_hsa05330 | 0.88537943 |
| 43 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.88335563 |
| 44 | Other glycan degradation_Homo sapiens_hsa00511 | 0.86338346 |
| 45 | Alzheimers disease_Homo sapiens_hsa05010 | 0.85141163 |
| 46 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.83949591 |
| 47 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.83413852 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.81221243 |
| 49 | Carbon metabolism_Homo sapiens_hsa01200 | 0.81211425 |
| 50 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.78949910 |
| 51 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.78190166 |
| 52 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.77968454 |
| 53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.75115783 |
| 54 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75050393 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.72459248 |
| 56 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.71503018 |
| 57 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.69117172 |
| 58 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.67766343 |
| 59 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.65443001 |
| 60 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.65266822 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.63994791 |
| 62 | Thyroid cancer_Homo sapiens_hsa05216 | 0.63292283 |
| 63 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.62422894 |
| 64 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.59997548 |
| 65 | HTLV-I infection_Homo sapiens_hsa05166 | 0.59809356 |
| 66 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.59727846 |
| 67 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.59093122 |
| 68 | Alcoholism_Homo sapiens_hsa05034 | 0.56802522 |
| 69 | Measles_Homo sapiens_hsa05162 | 0.55306288 |
| 70 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.54355962 |
| 71 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.54101566 |
| 72 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.53902846 |
| 73 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.53233499 |
| 74 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.50736303 |
| 75 | Apoptosis_Homo sapiens_hsa04210 | 0.50265069 |
| 76 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.49883260 |
| 77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.49244912 |
| 78 | Asthma_Homo sapiens_hsa05310 | 0.48169244 |
| 79 | Shigellosis_Homo sapiens_hsa05131 | 0.47259566 |
| 80 | Lysosome_Homo sapiens_hsa04142 | 0.46823505 |
| 81 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.46590836 |
| 82 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.44544171 |
| 83 | Huntingtons disease_Homo sapiens_hsa05016 | 0.44103533 |
| 84 | Parkinsons disease_Homo sapiens_hsa05012 | 0.43931523 |
| 85 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.43398826 |
| 86 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.43251363 |
| 87 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.41256200 |
| 88 | Hepatitis B_Homo sapiens_hsa05161 | 0.41150337 |
| 89 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.39677725 |
| 90 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.38486171 |
| 91 | Metabolic pathways_Homo sapiens_hsa01100 | 0.38383858 |
| 92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37554470 |
| 93 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.37266535 |
| 94 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36988583 |
| 95 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.36567082 |
| 96 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.34726184 |
| 97 | Galactose metabolism_Homo sapiens_hsa00052 | 0.34502574 |
| 98 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.32947977 |
| 99 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.31782236 |
| 100 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.31016197 |
| 101 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28759809 |
| 102 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.27613599 |
| 103 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26870450 |
| 104 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.26270238 |
| 105 | Influenza A_Homo sapiens_hsa05164 | 0.26122434 |
| 106 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.25524984 |
| 107 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.21598030 |
| 108 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.19448657 |
| 109 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.19084593 |
| 110 | Leishmaniasis_Homo sapiens_hsa05140 | 0.18566428 |
| 111 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.18216646 |
| 112 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.16920746 |
| 113 | Colorectal cancer_Homo sapiens_hsa05210 | 0.16750979 |
| 114 | Bladder cancer_Homo sapiens_hsa05219 | 0.15391459 |
| 115 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.14875834 |
| 116 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.14782214 |
| 117 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.14672837 |
| 118 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.14480980 |
| 119 | Viral myocarditis_Homo sapiens_hsa05416 | 0.14417626 |
| 120 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.14334461 |
| 121 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.13163624 |
| 122 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.13118387 |
| 123 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.12844802 |

