KXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.36667339
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.00465845
3chaperone-mediated protein transport (GO:0072321)3.96259036
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.95666685
5viral transcription (GO:0019083)3.89431340
6maturation of SSU-rRNA (GO:0030490)3.83749871
7ribosomal small subunit biogenesis (GO:0042274)3.81410339
8DNA deamination (GO:0045006)3.78988211
9translational termination (GO:0006415)3.75064031
10proteasome assembly (GO:0043248)3.74199972
11positive regulation of T cell apoptotic process (GO:0070234)3.67458679
12oxidative phosphorylation (GO:0006119)3.64524934
13negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.61780918
14formation of translation preinitiation complex (GO:0001731)3.59795199
15protein maturation by protein folding (GO:0022417)3.57661983
16base-excision repair, AP site formation (GO:0006285)3.56993114
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56852744
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55969103
19cotranslational protein targeting to membrane (GO:0006613)3.47666937
20translational elongation (GO:0006414)3.45774833
21positive regulation of lymphocyte apoptotic process (GO:0070230)3.45346897
22protein targeting to ER (GO:0045047)3.45183958
23macromolecular complex disassembly (GO:0032984)3.42125545
24negative regulation of B cell apoptotic process (GO:0002903)3.41243725
25negative regulation of DNA-templated transcription, elongation (GO:0032785)3.41147964
26ATP synthesis coupled proton transport (GO:0015986)3.40436098
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40436098
28establishment of protein localization to mitochondrion (GO:0072655)3.36050515
29protein localization to endoplasmic reticulum (GO:0070972)3.33402771
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.31392866
31GTP biosynthetic process (GO:0006183)3.30304812
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30259247
33telomere maintenance via semi-conservative replication (GO:0032201)3.25336501
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23766024
35termination of RNA polymerase III transcription (GO:0006386)3.23033904
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.23033904
37regulation of cellular amino acid metabolic process (GO:0006521)3.22015643
38purine deoxyribonucleotide catabolic process (GO:0009155)3.21652279
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21370687
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.19632615
41antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.19124071
42ribosomal large subunit biogenesis (GO:0042273)3.18557288
43purine nucleobase biosynthetic process (GO:0009113)3.18531646
44protein neddylation (GO:0045116)3.18224869
45UTP biosynthetic process (GO:0006228)3.18134567
46translation (GO:0006412)3.15889906
47guanosine-containing compound biosynthetic process (GO:1901070)3.15486967
48GDP-mannose metabolic process (GO:0019673)3.14761155
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14669528
50regulation of mitochondrial translation (GO:0070129)3.13570802
51protein targeting to membrane (GO:0006612)3.13308142
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13225159
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10618341
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09438764
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09438764
56translational initiation (GO:0006413)3.09178739
57deoxyribonucleotide catabolic process (GO:0009264)3.08668249
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08177891
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08177891
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08177891
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07992316
62water-soluble vitamin biosynthetic process (GO:0042364)3.07896587
63DNA strand elongation involved in DNA replication (GO:0006271)3.07776009
64respiratory chain complex IV assembly (GO:0008535)3.05763964
65cytochrome complex assembly (GO:0017004)3.05213627
66pentose metabolic process (GO:0019321)3.04085218
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03832691
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.01546616
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.01546616
70respiratory electron transport chain (GO:0022904)3.00990605
71nucleobase biosynthetic process (GO:0046112)3.00612380
72protein localization to mitochondrion (GO:0070585)3.00388201
73L-methionine salvage (GO:0071267)2.99794719
74L-methionine biosynthetic process (GO:0071265)2.99794719
75amino acid salvage (GO:0043102)2.99794719
76viral life cycle (GO:0019058)2.98804073
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.98657486
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96351057
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.96351057
80protein complex biogenesis (GO:0070271)2.96136769
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95498495
82negative regulation of ligase activity (GO:0051352)2.95498495
83rRNA metabolic process (GO:0016072)2.95076979
84electron transport chain (GO:0022900)2.94749986
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.94609525
86ncRNA 3-end processing (GO:0043628)2.94451572
87GMP metabolic process (GO:0046037)2.94144384
88deoxyribose phosphate catabolic process (GO:0046386)2.92872902
89DNA strand elongation (GO:0022616)2.92463437
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92422265
91iron-sulfur cluster assembly (GO:0016226)2.92102563
92metallo-sulfur cluster assembly (GO:0031163)2.92102563
93telomere maintenance via recombination (GO:0000722)2.92041088
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.89672056
95cellular protein complex disassembly (GO:0043624)2.89023080
96pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88482552
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85136232
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.85136232
99NADH dehydrogenase complex assembly (GO:0010257)2.85136232
100mRNA catabolic process (GO:0006402)2.83546686
101mitochondrial respiratory chain complex assembly (GO:0033108)2.82874116
102ribonucleoprotein complex biogenesis (GO:0022613)2.82741029
103rRNA modification (GO:0000154)2.81925549
104purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.81806811
105nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81397784
106CTP biosynthetic process (GO:0006241)2.81321089
107CTP metabolic process (GO:0046036)2.81321089
108purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80100166
109aerobic respiration (GO:0009060)2.76722032
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.76112032
111nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75518699
112UTP metabolic process (GO:0046051)2.75417912
113pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.75252785
114cellular component biogenesis (GO:0044085)2.73498738
115tooth mineralization (GO:0034505)2.73233433
116T cell apoptotic process (GO:0070231)2.71985893
117tRNA modification (GO:0006400)2.71840335
118RNA catabolic process (GO:0006401)2.71697015
119cytidine catabolic process (GO:0006216)2.70529171
120peptidyl-histidine modification (GO:0018202)2.69197383
121antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.69144444
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68506706
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65917988
124NADH metabolic process (GO:0006734)2.64660878
1257-methylguanosine mRNA capping (GO:0006370)2.59844219
126ubiquinone biosynthetic process (GO:0006744)2.59677915
127quinone biosynthetic process (GO:1901663)2.59677915
128positive regulation of ligase activity (GO:0051351)2.59444826
129response to interferon-beta (GO:0035456)2.56853650
130pseudouridine synthesis (GO:0001522)2.52472563
131IMP biosynthetic process (GO:0006188)2.52205454
132RNA capping (GO:0036260)2.51270110
1337-methylguanosine RNA capping (GO:0009452)2.51270110
134tricarboxylic acid cycle (GO:0006099)2.47517496
135positive regulation of cell cycle arrest (GO:0071158)2.46348505
136DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.46345884
137rRNA processing (GO:0006364)2.45405115
138DNA replication initiation (GO:0006270)2.45066689
139DNA replication checkpoint (GO:0000076)2.44425081
140mitotic recombination (GO:0006312)2.41271890
141protein complex disassembly (GO:0043241)2.41162654
142IMP metabolic process (GO:0046040)2.39800624
143protein targeting to mitochondrion (GO:0006626)2.39161638
144telomere maintenance via telomere lengthening (GO:0010833)2.38624893
145ribosome biogenesis (GO:0042254)2.38510174
146transcription-coupled nucleotide-excision repair (GO:0006283)2.38113848
147transcription from RNA polymerase I promoter (GO:0006360)2.37182512
148termination of RNA polymerase I transcription (GO:0006363)2.36787798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.36629636
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63220114
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51286186
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.28520506
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25712564
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.22892011
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.17584316
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03881952
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.85803778
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84470708
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66832705
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59395064
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.47580137
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41249338
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31766437
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.29475992
17VDR_23849224_ChIP-Seq_CD4+_Human2.24311962
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24266110
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23589531
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16978283
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11293276
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04935240
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02710274
24* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00730325
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00044391
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99189424
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96892404
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96219770
29FOXP3_21729870_ChIP-Seq_TREG_Human1.92964510
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89463446
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89424617
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88831717
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87761112
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87562422
35XRN2_22483619_ChIP-Seq_HELA_Human1.87100144
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.83705274
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82841308
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81013778
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.80738811
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79558812
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79349590
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78104407
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74477623
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.72645969
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.72402660
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71365624
47GABP_19822575_ChIP-Seq_HepG2_Human1.70597577
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70204672
49* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67505512
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63137867
51BCL6_27268052_Chip-Seq_Bcells_Human1.62580890
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58113085
53ELK1_19687146_ChIP-ChIP_HELA_Human1.55850097
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55757251
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.55564109
56LXR_22292898_ChIP-Seq_THP-1_Human1.53745860
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52798881
58P68_20966046_ChIP-Seq_HELA_Human1.51200795
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50350818
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.46794854
61SPI1_23547873_ChIP-Seq_NB4_Human1.43359179
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42694773
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41848592
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41518917
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.40643558
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38775096
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38376589
68TTF2_22483619_ChIP-Seq_HELA_Human1.36729632
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35510627
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.34699566
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34312770
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32766351
73BCOR_27268052_Chip-Seq_Bcells_Human1.32346422
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.31502350
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30856931
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30340787
77CTCF_20526341_ChIP-Seq_ESCs_Human1.29321435
78MYC_22102868_ChIP-Seq_BL_Human1.28383106
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.27830062
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27683259
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25318767
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24926068
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24614312
84E2F1_20622854_ChIP-Seq_HELA_Human1.22887752
85CIITA_25753668_ChIP-Seq_RAJI_Human1.22600036
86MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21820148
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21656405
88MAF_26560356_Chip-Seq_TH2_Human1.21372530
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.20615659
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20615511
91PHF8_20622854_ChIP-Seq_HELA_Human1.16514221
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13588251
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13172268
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12402843
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11453614
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09872952
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08198976
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07636148
99GATA1_22025678_ChIP-Seq_K562_Human1.06130056
100STAT1_20625510_ChIP-Seq_HELA_Human1.05971111
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05781159
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.05198353
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04625513
104KDM5A_27292631_Chip-Seq_BREAST_Human1.03668183
105AR_21909140_ChIP-Seq_LNCAP_Human1.03424264
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03343363
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.03038919
108SA1_27219007_Chip-Seq_Bcells_Human1.02987170
109CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02476975
110SPI1_20517297_ChIP-Seq_HL60_Human1.02311720
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01966354
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01159966
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01110396
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00305065
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98811453
116P300_27268052_Chip-Seq_Bcells_Human0.98398140
117CTCF_21964334_Chip-Seq_Bcells_Human0.97971532
118UTX_26944678_Chip-Seq_JUKART_Human0.96497577
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96398190
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96169330
121RXR_22158963_ChIP-Seq_LIVER_Mouse0.95760644
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95339927
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95256679
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94791048
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93871576
126MYC_18940864_ChIP-ChIP_HL60_Human0.93292863
127RARB_24833708_ChIP-Seq_LIVER_Mouse0.92968422
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92412292
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91440722
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91409124
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89360906
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89160105
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87895727
134E2F1_21310950_ChIP-Seq_MCF-7_Human0.87791396
135LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87538240
136TFEB_21752829_ChIP-Seq_HELA_Human0.86277068
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86164419
138VDR_21846776_ChIP-Seq_THP-1_Human0.83468157
139MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82700285
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82585010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.16412124
2MP0006292_abnormal_olfactory_placode3.08012047
3MP0001835_abnormal_antigen_presentation2.91605237
4MP0003693_abnormal_embryo_hatching2.77082273
5MP0009785_altered_susceptibility_to2.59618946
6MP0000678_abnormal_parathyroid_gland2.59454976
7MP0003186_abnormal_redox_activity2.53438167
8MP0005670_abnormal_white_adipose2.30215060
9MP0006036_abnormal_mitochondrial_physio2.28636408
10MP0002139_abnormal_hepatobiliary_system2.11800782
11MP0005360_urolithiasis2.11700002
12MP0001853_heart_inflammation2.11642856
13MP0002396_abnormal_hematopoietic_system2.09160533
14MP0005671_abnormal_response_to2.06302314
15MP0000049_abnormal_middle_ear2.05696886
16MP0003646_muscle_fatigue2.03237245
17MP0002148_abnormal_hypersensitivity_rea2.03215690
18MP0004957_abnormal_blastocyst_morpholog2.01734953
19MP0002653_abnormal_ependyma_morphology2.01408306
20MP0005379_endocrine/exocrine_gland_phen1.95526761
21MP0008057_abnormal_DNA_replication1.88974020
22MP0000685_abnormal_immune_system1.86114889
23MP0005025_abnormal_response_to1.85639293
24MP0002132_abnormal_respiratory_system1.85443507
25MP0003763_abnormal_thymus_physiology1.84709741
26MP0003191_abnormal_cellular_cholesterol1.81127989
27MP0003724_increased_susceptibility_to1.76806996
28MP0005085_abnormal_gallbladder_physiolo1.75412125
29MP0003077_abnormal_cell_cycle1.74076751
30MP0009840_abnormal_foam_cell1.72462529
31MP0005365_abnormal_bile_salt1.71582274
32MP0001764_abnormal_homeostasis1.69824163
33MP0010094_abnormal_chromosome_stability1.69762418
34MP0004147_increased_porphyrin_level1.69309936
35MP0003111_abnormal_nucleus_morphology1.69114614
36MP0009333_abnormal_splenocyte_physiolog1.66184052
37MP0005000_abnormal_immune_tolerance1.63420470
38MP0008058_abnormal_DNA_repair1.62174687
39MP0003436_decreased_susceptibility_to1.60266606
40MP0001800_abnormal_humoral_immune1.59602061
41MP0008875_abnormal_xenobiotic_pharmacok1.59452149
42MP0005410_abnormal_fertilization1.58021780
43MP0006082_CNS_inflammation1.55356753
44MP0002723_abnormal_immune_serum1.54878675
45MP0002163_abnormal_gland_morphology1.53087279
46MP0005387_immune_system_phenotype1.48984164
47MP0001790_abnormal_immune_system1.48984164
48MP0002419_abnormal_innate_immunity1.48737699
49MP0002452_abnormal_antigen_presenting1.47227908
50MP0010030_abnormal_orbit_morphology1.46728614
51MP0001819_abnormal_immune_cell1.45957808
52MP0002420_abnormal_adaptive_immunity1.45300264
53MP0008007_abnormal_cellular_replicative1.44869219
54MP0008469_abnormal_protein_level1.44040339
55MP0009379_abnormal_foot_pigmentation1.42053428
56MP0003656_abnormal_erythrocyte_physiolo1.40729742
57MP0005075_abnormal_melanosome_morpholog1.40685737
58MP0006035_abnormal_mitochondrial_morpho1.40002494
59MP0002398_abnormal_bone_marrow1.38787969
60MP0000681_abnormal_thyroid_gland1.37632891
61MP0009053_abnormal_anal_canal1.35217331
62MP0005332_abnormal_amino_acid1.35139925
63MP0003786_premature_aging1.34698910
64MP0002249_abnormal_larynx_morphology1.33570642
65MP0001545_abnormal_hematopoietic_system1.32497370
66MP0005397_hematopoietic_system_phenotyp1.32497370
67MP0001727_abnormal_embryo_implantation1.30744675
68MP0000689_abnormal_spleen_morphology1.30386704
69MP0005451_abnormal_body_composition1.29967644
70MP0001905_abnormal_dopamine_level1.29173627
71MP0000716_abnormal_immune_system1.26633039
72MP0002722_abnormal_immune_system1.25289218
73MP0003195_calcinosis1.25126271
74MP0010155_abnormal_intestine_physiology1.24769347
75MP0001845_abnormal_inflammatory_respons1.23280001
76MP0002429_abnormal_blood_cell1.22267860
77MP0002405_respiratory_system_inflammati1.19941588
78MP0000858_altered_metastatic_potential1.18671774
79MP0005646_abnormal_pituitary_gland1.17645926
80MP0004145_abnormal_muscle_electrophysio1.17412340
81MP0002876_abnormal_thyroid_physiology1.16619874
82MP0005319_abnormal_enzyme/_coenzyme1.15870302
83MP0005389_reproductive_system_phenotype1.15610954
84MP0005058_abnormal_lysosome_morphology1.14541268
85MP0002160_abnormal_reproductive_system1.14508880
86MP0005083_abnormal_biliary_tract1.13850025
87MP0005464_abnormal_platelet_physiology1.12102594
88MP0001542_abnormal_bone_strength1.11543459
89MP0005408_hypopigmentation1.11324727
90MP0003718_maternal_effect1.10470296
91MP0004858_abnormal_nervous_system1.10011672
92MP0004084_abnormal_cardiac_muscle1.09171114
93MP0009643_abnormal_urine_homeostasis1.09116063
94MP0002277_abnormal_respiratory_mucosa1.08582345
95MP0000490_abnormal_crypts_of1.06870610
96MP0008872_abnormal_physiological_respon1.06204825
97MP0002837_dystrophic_cardiac_calcinosis1.04323343
98MP0005584_abnormal_enzyme/coenzyme_acti1.03101504
99MP0001348_abnormal_lacrimal_gland1.02295694
100MP0009764_decreased_sensitivity_to1.01497078
101MP0001919_abnormal_reproductive_system1.01435585
102MP0002019_abnormal_tumor_incidence1.01256659
103MP0005636_abnormal_mineral_homeostasis1.01253139
104MP0000613_abnormal_salivary_gland1.00804546
105MP0002138_abnormal_hepatobiliary_system1.00736670
106MP0001661_extended_life_span1.00485929
107MP0009697_abnormal_copulation0.99315262
108MP0003878_abnormal_ear_physiology0.99182221
109MP0005377_hearing/vestibular/ear_phenot0.99182221
110MP0002006_tumorigenesis0.98901109
111MP0000750_abnormal_muscle_regeneration0.98887624
112MP0002166_altered_tumor_susceptibility0.97776580
113MP0001873_stomach_inflammation0.96743697
114MP0010352_gastrointestinal_tract_polyps0.96732923
115MP0005266_abnormal_metabolism0.96620044
116MP0009765_abnormal_xenobiotic_induced0.96038125
117MP0000749_muscle_degeneration0.94883847
118MP0004782_abnormal_surfactant_physiolog0.94477100
119MP0003938_abnormal_ear_development0.94076035
120MP0004133_heterotaxia0.93418106
121MP0000609_abnormal_liver_physiology0.92836797
122MP0005330_cardiomyopathy0.91797826
123MP0002210_abnormal_sex_determination0.90492727
124MP0004381_abnormal_hair_follicle0.89977082
125MP0000372_irregular_coat_pigmentation0.88506564
126MP0004142_abnormal_muscle_tone0.88355987
127MP0003866_abnormal_defecation0.88051022
128MP0009763_increased_sensitivity_to0.87784435
129MP0002102_abnormal_ear_morphology0.87010688
130MP0000343_altered_response_to0.84817928
131MP0008995_early_reproductive_senescence0.84537590
132MP0005084_abnormal_gallbladder_morpholo0.83351738
133MP0004185_abnormal_adipocyte_glucose0.82892802
134MP0000015_abnormal_ear_pigmentation0.82003407
135MP0009278_abnormal_bone_marrow0.81855502
136MP0003123_paternal_imprinting0.81828402
137MP0000358_abnormal_cell_content/0.81777498
138MP0000313_abnormal_cell_death0.81728481
139MP0003638_abnormal_response/metabolism_0.81660789
140MP0009250_abnormal_appendicular_skeleto0.81511874
141MP0001145_abnormal_male_reproductive0.81233571
142MP0008932_abnormal_embryonic_tissue0.80389338
143MP0001666_abnormal_nutrient_absorption0.80101852
144MP0003828_pulmonary_edema0.78921501
145MP0000703_abnormal_thymus_morphology0.78543306

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.31330166
2Acute necrotizing encephalopathy (HP:0006965)4.15260560
3Hepatocellular necrosis (HP:0001404)4.11638562
4Mitochondrial inheritance (HP:0001427)4.05695586
5Abnormal mitochondria in muscle tissue (HP:0008316)4.03274537
6Increased CSF lactate (HP:0002490)3.84533118
7Acute encephalopathy (HP:0006846)3.80886818
8Abnormality of cells of the erythroid lineage (HP:0012130)3.72123903
9Severe visual impairment (HP:0001141)3.70592930
10Abnormal number of erythroid precursors (HP:0012131)3.69167271
113-Methylglutaconic aciduria (HP:0003535)3.51163580
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47369254
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47369254
14Reticulocytopenia (HP:0001896)3.36736514
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24354540
16Progressive macrocephaly (HP:0004481)3.19773978
17Lipid accumulation in hepatocytes (HP:0006561)3.19346444
18Increased serum lactate (HP:0002151)3.19312278
19Increased hepatocellular lipid droplets (HP:0006565)3.18489507
20Cerebral edema (HP:0002181)3.17672979
21Hyperthyroidism (HP:0000836)3.17346908
22Increased intramyocellular lipid droplets (HP:0012240)3.06402721
23Abnormality of fatty-acid metabolism (HP:0004359)3.05833305
24Lactic acidosis (HP:0003128)3.04921764
25Increased muscle lipid content (HP:0009058)3.02326550
26Generalized aminoaciduria (HP:0002909)2.96288513
27Type I transferrin isoform profile (HP:0003642)2.90177222
28Dicarboxylic aciduria (HP:0003215)2.87521462
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87521462
30Exertional dyspnea (HP:0002875)2.86896194
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.78132728
32Exercise intolerance (HP:0003546)2.76678760
33Renal Fanconi syndrome (HP:0001994)2.76587049
34Microretrognathia (HP:0000308)2.76050047
35Respiratory failure (HP:0002878)2.71607557
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66695226
37Nausea (HP:0002018)2.65499788
38Porencephaly (HP:0002132)2.63365723
39Increased serum pyruvate (HP:0003542)2.61380803
40Abnormality of glycolysis (HP:0004366)2.61380803
41Aplastic anemia (HP:0001915)2.60303378
42Pendular nystagmus (HP:0012043)2.59659133
43Lethargy (HP:0001254)2.58043785
44Absent thumb (HP:0009777)2.56796603
45Reduced antithrombin III activity (HP:0001976)2.52401975
46Recurrent abscess formation (HP:0002722)2.48814768
47Macrocytic anemia (HP:0001972)2.46803134
48Respiratory difficulties (HP:0002880)2.46504151
49Multiple enchondromatosis (HP:0005701)2.44873221
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43720897
51Glycosuria (HP:0003076)2.43311751
52Abnormality of urine glucose concentration (HP:0011016)2.43311751
53Truncus arteriosus (HP:0001660)2.43214144
54Microvesicular hepatic steatosis (HP:0001414)2.42608118
55Cleft eyelid (HP:0000625)2.42263419
56Hypertensive crisis (HP:0100735)2.41708015
57Petechiae (HP:0000967)2.40990906
58CNS demyelination (HP:0007305)2.40394619
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37653382
60Abnormality of pyrimidine metabolism (HP:0004353)2.36949042
61Thrombocytosis (HP:0001894)2.36617057
62Rough bone trabeculation (HP:0100670)2.33878683
63Elevated erythrocyte sedimentation rate (HP:0003565)2.33807575
64Sclerocornea (HP:0000647)2.31271947
65Prolonged neonatal jaundice (HP:0006579)2.30336763
66Cerebral hypomyelination (HP:0006808)2.30162323
67IgM deficiency (HP:0002850)2.29727978
68Rhabdomyolysis (HP:0003201)2.27179321
69Abnormal rod and cone electroretinograms (HP:0008323)2.26053727
70Horseshoe kidney (HP:0000085)2.23032426
71Hyperglycinuria (HP:0003108)2.18757909
72Recurrent bacterial skin infections (HP:0005406)2.18333862
73Pallor (HP:0000980)2.17290726
74Asplenia (HP:0001746)2.17242127
75Hyperglycinemia (HP:0002154)2.16923379
76Short femoral neck (HP:0100864)2.15174555
77Opisthotonus (HP:0002179)2.12881046
78Pancreatic fibrosis (HP:0100732)2.11671665
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.11449849
80Aplasia/Hypoplasia of the spleen (HP:0010451)2.10722857
81Hyperammonemia (HP:0001987)2.09235358
82Visual hallucinations (HP:0002367)2.05831290
83Pancytopenia (HP:0001876)2.05632802
84Hypoglycemic coma (HP:0001325)2.05471566
85Abnormality of DNA repair (HP:0003254)2.03454188
86Hypoplasia of the uterus (HP:0000013)2.02797166
87Esophageal neoplasm (HP:0100751)2.02252580
88Neoplasm of head and neck (HP:0012288)2.02252580
89Palpitations (HP:0001962)2.00363710
90Vacuolated lymphocytes (HP:0001922)1.99828030
91Methylmalonic acidemia (HP:0002912)1.98523008
92Pancreatic cysts (HP:0001737)1.98446101
93Abnormality of glycolipid metabolism (HP:0010969)1.96127646
94Abnormality of liposaccharide metabolism (HP:0010968)1.96127646
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.96127646
96Abnormality of subcutaneous fat tissue (HP:0001001)1.95749604
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94553655
98Abnormal protein N-linked glycosylation (HP:0012347)1.94553655
99Abnormal protein glycosylation (HP:0012346)1.94553655
100Abnormal glycosylation (HP:0012345)1.94553655
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94122158
102Renal cortical cysts (HP:0000803)1.93737286
103Abnormality of serine family amino acid metabolism (HP:0010894)1.92179855
104Abnormality of glycine metabolism (HP:0010895)1.92179855
105Concave nail (HP:0001598)1.91951717
106Oral leukoplakia (HP:0002745)1.91687215
107Obstructive lung disease (HP:0006536)1.91202677
108Chronic obstructive pulmonary disease (HP:0006510)1.91202677
109Proximal tubulopathy (HP:0000114)1.90702752
110Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89983716
111IgG deficiency (HP:0004315)1.89445104
112Neutropenia (HP:0001875)1.88843947
113Abnormality of reticulocytes (HP:0004312)1.88758967
114Abnormal number of incisors (HP:0011064)1.88216459
115Dysautonomia (HP:0002459)1.87614189
116Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86065086
117Short 1st metacarpal (HP:0010034)1.86065086
118Tinnitus (HP:0000360)1.85247972
119Aplasia/hypoplasia of the uterus (HP:0008684)1.85196698
120Poor head control (HP:0002421)1.85147108
121Testicular atrophy (HP:0000029)1.84808793
122Cerebral palsy (HP:0100021)1.84634688
123Leukodystrophy (HP:0002415)1.84178585
124Metabolic acidosis (HP:0001942)1.83276282
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82099577
126Ragged-red muscle fibers (HP:0003200)1.80844892
127Squamous cell carcinoma (HP:0002860)1.80253882
128Abnormality of serum amino acid levels (HP:0003112)1.79986300
129Carpal bone hypoplasia (HP:0001498)1.79217452
130Vomiting (HP:0002013)1.78904449
131Autoimmune thrombocytopenia (HP:0001973)1.78348026
132Redundant skin (HP:0001582)1.78202787
133Severe muscular hypotonia (HP:0006829)1.76684460
134Hepatosplenomegaly (HP:0001433)1.76478172
135Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.75676285
136Gliosis (HP:0002171)1.74338013
137Increased IgM level (HP:0003496)1.73983721
138Methylmalonic aciduria (HP:0012120)1.73963492
139Abnormality of the proximal phalanges of the hand (HP:0009834)1.72496761
140Emotional lability (HP:0000712)1.72272591
141Progressive muscle weakness (HP:0003323)1.72238537
142Hyperalaninemia (HP:0003348)1.71847666
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71847666
144Abnormality of macrophages (HP:0004311)1.70189650
145Birth length less than 3rd percentile (HP:0003561)1.68978265
146Optic disc pallor (HP:0000543)1.68168313
147Eczematoid dermatitis (HP:0000976)1.66952598
148Hypobetalipoproteinemia (HP:0003563)1.65285592
149Abnormality of renal resorption (HP:0011038)1.63341942
150Myoglobinuria (HP:0002913)1.63301195
151Increased serum ferritin (HP:0003281)1.62288430

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.13047356
2NME23.47618348
3BUB13.42494725
4STK163.06022048
5WEE12.81348391
6BCKDK2.65808319
7EIF2AK12.58229459
8SMG12.48730117
9PIM22.47246380
10MAP4K12.18441760
11IRAK32.03787573
12TXK2.00957673
13TSSK61.98667282
14EIF2AK31.92264269
15BRSK21.90337207
16IRAK41.83477886
17TYK21.77219411
18MAP3K141.72616685
19TBK11.66352800
20MYLK1.65108688
21VRK11.61942925
22NEK11.53427465
23LIMK11.51488023
24OBSCN1.49504259
25ZAK1.49005652
26TEC1.48407699
27BLK1.47155535
28PRKD21.46880603
29MST41.43535159
30IKBKB1.43337889
31GRK11.41296446
32IKBKE1.36548332
33PDK31.32265331
34PDK41.32265331
35FLT31.30042978
36CDK191.29030293
37MAP3K121.28549387
38BTK1.28447687
39KIT1.26131399
40MAP4K21.25850132
41ZAP701.22762244
42TESK21.22371261
43ARAF1.15477164
44MAP2K31.14980084
45SRPK11.13427075
46ACVR1B1.12204304
47DAPK31.10795948
48NUAK11.09364137
49ADRBK21.09146768
50ILK1.08232520
51DAPK11.08053483
52CDK81.06567356
53PIM11.06503872
54PLK41.05243403
55KDR1.00919358
56STK40.97189688
57MAP3K30.94887172
58TLK10.93488499
59CCNB10.91990106
60CDC70.90937972
61NEK90.90934905
62NLK0.90854965
63ERN10.89603141
64MAPKAPK30.88818751
65JAK30.88061529
66RPS6KA40.88059324
67SYK0.87865953
68TRIB30.86234073
69CLK10.85939284
70PAK10.85761642
71PDK20.85221224
72MAP3K110.84822995
73MAP3K80.84531009
74TAF10.83104536
75CSNK1G30.81863515
76CDK70.81124479
77CHEK20.80966862
78PRKCI0.80864474
79DYRK20.80831810
80RPS6KB20.79642362
81EIF2AK20.75703078
82NME10.75322784
83AURKB0.75260837
84PLK10.74785612
85NEK20.74251919
86BRSK10.74250344
87EPHA20.73992186
88PBK0.73493292
89BRAF0.73141403
90ATR0.72149125
91GRK60.72128233
92MUSK0.72017515
93CSF1R0.71261029
94RPS6KA60.69036124
95PASK0.66827340
96TGFBR10.64830329
97GRK70.63039286
98ABL20.62962043
99PIK3CG0.62861069
100TTK0.62017557
101TAOK20.61843869
102PINK10.61648264
103INSRR0.60665441
104WNK40.60257569
105STK240.60189210
106BMX0.59940686
107DYRK30.59915572
108TIE10.59709574
109CSNK2A10.59303629
110IRAK10.58718156
111RPS6KA50.57701901
112CDK40.57325239
113LRRK20.56310459
114MAP2K60.56128548
115AURKA0.55773363
116ITK0.55298777
117FES0.54921737
118HIPK20.54605661
119LYN0.54509805
120MAPK110.54266704
121FGFR40.52779326
122MAPKAPK50.52341389
123RPS6KC10.51764362
124RPS6KL10.51764362
125STK100.48942583
126CSNK2A20.48875488
127CHUK0.48387000
128BMPR1B0.47826704
129TNK20.45395794
130TESK10.45360910
131JAK10.44330435
132MAP2K20.42358554
133GRK50.40202490
134EPHB10.39206008
135CHEK10.36754987
136CSNK1A1L0.36680515
137CDK90.35710664
138PRKD30.33060065
139MAPKAPK20.32936571
140LMTK20.30752014
141PAK40.30504983
142CSNK1G10.29544863
143AKT20.28988819

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.65659030
2Proteasome_Homo sapiens_hsa030503.59962300
3DNA replication_Homo sapiens_hsa030302.95842680
4RNA polymerase_Homo sapiens_hsa030202.73626756
5Oxidative phosphorylation_Homo sapiens_hsa001902.43512819
6Mismatch repair_Homo sapiens_hsa034302.30444460
7Parkinsons disease_Homo sapiens_hsa050122.29034295
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21727427
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17152910
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17019175
11Pyrimidine metabolism_Homo sapiens_hsa002402.07497483
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05317720
13Base excision repair_Homo sapiens_hsa034101.88988050
14Homologous recombination_Homo sapiens_hsa034401.77469974
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71945139
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68688858
17Protein export_Homo sapiens_hsa030601.64946951
18Nucleotide excision repair_Homo sapiens_hsa034201.64037283
19Huntingtons disease_Homo sapiens_hsa050161.54005224
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.52699247
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50613061
22Folate biosynthesis_Homo sapiens_hsa007901.47689639
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44883734
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44784067
25Carbon metabolism_Homo sapiens_hsa012001.34389328
26Alzheimers disease_Homo sapiens_hsa050101.32669232
27Spliceosome_Homo sapiens_hsa030401.32454893
28Pentose phosphate pathway_Homo sapiens_hsa000301.32091794
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.29534249
30Propanoate metabolism_Homo sapiens_hsa006401.26364451
31RNA transport_Homo sapiens_hsa030131.24472393
32Vitamin B6 metabolism_Homo sapiens_hsa007501.23613297
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23521850
34One carbon pool by folate_Homo sapiens_hsa006701.23058586
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22415415
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19665569
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15121201
38Fatty acid elongation_Homo sapiens_hsa000621.14992010
39Peroxisome_Homo sapiens_hsa041461.13500701
40Glutathione metabolism_Homo sapiens_hsa004801.11895346
41Purine metabolism_Homo sapiens_hsa002301.11003342
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07755601
43Sulfur relay system_Homo sapiens_hsa041221.06092098
44Biosynthesis of amino acids_Homo sapiens_hsa012301.05034157
45Fatty acid degradation_Homo sapiens_hsa000711.04144035
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01588388
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00899035
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.00597810
49Primary immunodeficiency_Homo sapiens_hsa053400.98399770
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95408504
51Allograft rejection_Homo sapiens_hsa053300.94569559
52Pyruvate metabolism_Homo sapiens_hsa006200.94397835
53Legionellosis_Homo sapiens_hsa051340.93310645
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92639666
55Graft-versus-host disease_Homo sapiens_hsa053320.92256259
56Basal transcription factors_Homo sapiens_hsa030220.91686573
57RNA degradation_Homo sapiens_hsa030180.91404942
58Autoimmune thyroid disease_Homo sapiens_hsa053200.90443289
59beta-Alanine metabolism_Homo sapiens_hsa004100.90437600
60Non-homologous end-joining_Homo sapiens_hsa034500.90176035
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.89780326
62N-Glycan biosynthesis_Homo sapiens_hsa005100.89499398
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88923259
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.88057653
65Antigen processing and presentation_Homo sapiens_hsa046120.85203629
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85144053
67Fructose and mannose metabolism_Homo sapiens_hsa000510.84972616
68Fanconi anemia pathway_Homo sapiens_hsa034600.84962807
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82431164
70Phenylalanine metabolism_Homo sapiens_hsa003600.82421272
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82395913
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81642338
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78900762
74Metabolic pathways_Homo sapiens_hsa011000.76382751
75Other glycan degradation_Homo sapiens_hsa005110.75625200
76Chemical carcinogenesis_Homo sapiens_hsa052040.75540161
77Galactose metabolism_Homo sapiens_hsa000520.74034569
78Herpes simplex infection_Homo sapiens_hsa051680.73806759
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73669623
80Cell cycle_Homo sapiens_hsa041100.72364256
81Tryptophan metabolism_Homo sapiens_hsa003800.70062754
82Measles_Homo sapiens_hsa051620.69221113
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69137253
84Arginine and proline metabolism_Homo sapiens_hsa003300.68089060
85Histidine metabolism_Homo sapiens_hsa003400.66471004
86Epstein-Barr virus infection_Homo sapiens_hsa051690.66014181
87Systemic lupus erythematosus_Homo sapiens_hsa053220.65707204
88Selenocompound metabolism_Homo sapiens_hsa004500.63392606
89Arachidonic acid metabolism_Homo sapiens_hsa005900.63364374
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.62583345
91Fatty acid metabolism_Homo sapiens_hsa012120.62519775
92Sulfur metabolism_Homo sapiens_hsa009200.61726860
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.61683280
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60468952
95Type I diabetes mellitus_Homo sapiens_hsa049400.57536568
96Regulation of autophagy_Homo sapiens_hsa041400.56326124
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56326063
98Phototransduction_Homo sapiens_hsa047440.55395084
99Caffeine metabolism_Homo sapiens_hsa002320.55275269
100Staphylococcus aureus infection_Homo sapiens_hsa051500.54882516
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.53954294
102Cardiac muscle contraction_Homo sapiens_hsa042600.53612954
103p53 signaling pathway_Homo sapiens_hsa041150.53417595
104Leishmaniasis_Homo sapiens_hsa051400.52868781
105Tyrosine metabolism_Homo sapiens_hsa003500.52565016
106Hematopoietic cell lineage_Homo sapiens_hsa046400.51104418
107Retinol metabolism_Homo sapiens_hsa008300.50204426
108Rheumatoid arthritis_Homo sapiens_hsa053230.47491116
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.47163956
110Starch and sucrose metabolism_Homo sapiens_hsa005000.42253905
111Bladder cancer_Homo sapiens_hsa052190.41612330
112Asthma_Homo sapiens_hsa053100.41268302
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40831583
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40667350
115Shigellosis_Homo sapiens_hsa051310.39034373
116Collecting duct acid secretion_Homo sapiens_hsa049660.37472207
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36087670
118Lysosome_Homo sapiens_hsa041420.33824230
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33509723
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32370541
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29562549
122HTLV-I infection_Homo sapiens_hsa051660.26727107
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26351980
124Melanoma_Homo sapiens_hsa052180.22295101
125Basal cell carcinoma_Homo sapiens_hsa052170.19044407
126Apoptosis_Homo sapiens_hsa042100.18827737
127Vibrio cholerae infection_Homo sapiens_hsa051100.18361061
128Viral carcinogenesis_Homo sapiens_hsa052030.17054866

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