KY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.15108136
2muscle filament sliding (GO:0030049)9.12024386
3actin-myosin filament sliding (GO:0033275)9.12024386
4sarcoplasmic reticulum calcium ion transport (GO:0070296)8.70182044
5actin-mediated cell contraction (GO:0070252)7.55553006
6skeletal muscle contraction (GO:0003009)7.47756008
7skeletal muscle adaptation (GO:0043501)6.69167550
8sarcomere organization (GO:0045214)6.62757348
9plasma membrane repair (GO:0001778)6.59921278
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.19551206
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.73416096
12myofibril assembly (GO:0030239)5.65812647
13actin filament-based movement (GO:0030048)5.60422500
14striated muscle contraction (GO:0006941)5.47887558
15detection of molecule of bacterial origin (GO:0032490)5.35685578
16carnitine shuttle (GO:0006853)5.29818060
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.26032402
18creatine metabolic process (GO:0006600)5.17859805
19glycogen catabolic process (GO:0005980)4.92311783
20skeletal muscle fiber development (GO:0048741)4.74240088
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.66988212
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.64598671
23glucan catabolic process (GO:0009251)4.62466698
24pyrimidine ribonucleoside catabolic process (GO:0046133)4.60682748
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.60302514
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.59401189
27microglial cell activation (GO:0001774)4.52868663
28regulation of cell communication by electrical coupling (GO:0010649)4.51331889
29actomyosin structure organization (GO:0031032)4.46987822
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.42682774
31positive regulation by symbiont of host defense response (GO:0052509)4.40308115
32modulation by symbiont of host defense response (GO:0052031)4.40308115
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40308115
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40308115
35positive regulation by organism of defense response of other organism involved in symbiotic interact4.40308115
36modulation by symbiont of host immune response (GO:0052553)4.40308115
37cardiac muscle contraction (GO:0060048)4.36316713
38fatty acid transmembrane transport (GO:1902001)4.33778182
39muscle contraction (GO:0006936)4.32350851
40cellular polysaccharide catabolic process (GO:0044247)4.30175852
41purine nucleotide salvage (GO:0032261)4.23178678
42cardiac myofibril assembly (GO:0055003)4.20726947
43response to inactivity (GO:0014854)4.15484765
44cytidine deamination (GO:0009972)4.13880785
45cytidine metabolic process (GO:0046087)4.13880785
46cytidine catabolic process (GO:0006216)4.13880785
47polysaccharide catabolic process (GO:0000272)4.08122940
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04484734
49negative regulation of cell killing (GO:0031342)4.04484734
50tricarboxylic acid cycle (GO:0006099)4.02011491
51COPI coating of Golgi vesicle (GO:0048205)4.01567692
52Golgi transport vesicle coating (GO:0048200)4.01567692
53myotube cell development (GO:0014904)3.97364586
54striated muscle atrophy (GO:0014891)3.96919304
55response to muscle activity (GO:0014850)3.94797939
56muscle system process (GO:0003012)3.93346855
57striated muscle adaptation (GO:0014888)3.89825484
58glycogen biosynthetic process (GO:0005978)3.88318671
59glucan biosynthetic process (GO:0009250)3.88318671
60carnitine transmembrane transport (GO:1902603)3.84562315
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.83565377
62macrophage activation (GO:0042116)3.76633971
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.72292236
64glycogen metabolic process (GO:0005977)3.70561359
65skeletal muscle tissue regeneration (GO:0043403)3.68718817
66muscle fiber development (GO:0048747)3.67454330
67positive regulation of gamma-delta T cell activation (GO:0046645)3.66492080
68regulation of B cell receptor signaling pathway (GO:0050855)3.64606956
69cellular glucan metabolic process (GO:0006073)3.63675359
70glucan metabolic process (GO:0044042)3.63675359
71regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.59417832
72regulation of membrane repolarization (GO:0060306)3.59095719
73regulation of striated muscle contraction (GO:0006942)3.58232518
74cellular extravasation (GO:0045123)3.57247811
75regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.55332984
76regulation of calcium ion transmembrane transporter activity (GO:1901019)3.55186975
77regulation of calcium ion transmembrane transport (GO:1903169)3.55186975
78regulation of actin filament-based movement (GO:1903115)3.54875773
79heart contraction (GO:0060047)3.51053553
80heart process (GO:0003015)3.51053553
81positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.50409504
82macrophage activation involved in immune response (GO:0002281)3.50275409
83regulation of relaxation of muscle (GO:1901077)3.48611491
84negative regulation of cAMP-mediated signaling (GO:0043951)3.48577667
85carnitine transport (GO:0015879)3.48041170
86amino-acid betaine transport (GO:0015838)3.48041170
87regulation of acyl-CoA biosynthetic process (GO:0050812)3.46307547
88neutrophil mediated immunity (GO:0002446)3.45392145
89positive regulation of myoblast differentiation (GO:0045663)3.42999410
90neuronal action potential propagation (GO:0019227)3.42978125
91detection of calcium ion (GO:0005513)3.42111798
92cardiac muscle cell development (GO:0055013)3.40841979
93positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.40475565
94muscle atrophy (GO:0014889)3.38746088
95detection of external biotic stimulus (GO:0098581)3.35492410
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.32644221
97negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.31073027
98positive regulation of cation channel activity (GO:2001259)3.30788827
99cellular response to epinephrine stimulus (GO:0071872)3.21447050
100regulation of gamma-delta T cell differentiation (GO:0045586)3.20140001
101COPII vesicle coating (GO:0048208)3.19994913
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.18945588
103cardiac cell development (GO:0055006)3.15837146
104antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14524770
105regulation of skeletal muscle cell differentiation (GO:2001014)3.13073433
106negative regulation of inclusion body assembly (GO:0090084)3.12672175
107regulation of gamma-delta T cell activation (GO:0046643)3.12571628
108regulation of type B pancreatic cell apoptotic process (GO:2000674)3.12012302
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.11383644
110muscle cell cellular homeostasis (GO:0046716)3.11072868
111muscle adaptation (GO:0043500)3.09556230
112regulation of cofactor metabolic process (GO:0051193)3.08964517
113regulation of coenzyme metabolic process (GO:0051196)3.08964517
114regulation of interferon-beta biosynthetic process (GO:0045357)3.04631022
115ventricular cardiac muscle cell action potential (GO:0086005)3.03223107
116striated muscle cell development (GO:0055002)3.02541290
117IMP metabolic process (GO:0046040)2.99701339
118cardiac muscle hypertrophy (GO:0003300)2.98128506
119negative regulation of muscle hypertrophy (GO:0014741)2.97280883
120NADH metabolic process (GO:0006734)2.96048227
121regulation of sequestering of triglyceride (GO:0010889)2.95568396
122response to epinephrine (GO:0071871)2.94623031
123tricarboxylic acid metabolic process (GO:0072350)2.94539594
124response to host immune response (GO:0052572)2.94302497
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94302497
126regulation of oxidative phosphorylation (GO:0002082)2.93926925
127response to activity (GO:0014823)2.92429704
128skeletal muscle tissue development (GO:0007519)2.91923169
129myeloid leukocyte mediated immunity (GO:0002444)2.91523447
130protein maturation by protein folding (GO:0022417)2.90895093
131endocrine pancreas development (GO:0031018)2.90635867
132relaxation of muscle (GO:0090075)2.89652892
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89158558
134negative regulation of muscle contraction (GO:0045932)2.88878625
135negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.88564225
136regulation of necroptotic process (GO:0060544)2.87914662
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85407177
138detection of biotic stimulus (GO:0009595)2.82708901
139regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81860486
140striated muscle hypertrophy (GO:0014897)2.80431338
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.78861179
142negative regulation of T cell mediated immunity (GO:0002710)2.77729020
143regulation of myoblast differentiation (GO:0045661)2.76237716
144regulation of platelet aggregation (GO:0090330)2.72165861
145neural tube formation (GO:0001841)2.69308209
146positive regulation of myotube differentiation (GO:0010831)2.68017015
147response to host (GO:0075136)2.66451282
148response to host defenses (GO:0052200)2.66451282
149response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66451282
150regulation of interleukin-6 biosynthetic process (GO:0045408)2.66164128
151phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62958552
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58328360
153positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57135816
154establishment of protein localization to Golgi (GO:0072600)2.55666697
155macroautophagy (GO:0016236)2.54264796
156muscle hypertrophy (GO:0014896)2.52799993
157regulation of skeletal muscle fiber development (GO:0048742)2.51460051
158protein targeting to Golgi (GO:0000042)2.50723764
159* muscle structure development (GO:0061061)2.48403556
160phagocytosis, recognition (GO:0006910)2.48122463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.51486554
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.49342970
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.96765759
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.81438375
5TBX20_22328084_ChIP-Seq_HEART_Mouse2.61586366
6TBX20_22080862_ChIP-Seq_HEART_Mouse2.61586366
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52425886
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.52168333
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51419194
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46886613
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.43824126
12EZH2_22144423_ChIP-Seq_EOC_Human2.36148182
13GATA1_22025678_ChIP-Seq_K562_Human2.34493254
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33317213
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31334971
16GBX2_23144817_ChIP-Seq_PC3_Human2.27450204
17RUNX_20019798_ChIP-Seq_JUKART_Human2.15955968
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.14396171
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07919196
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07841987
21MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.06587842
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01780842
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99948901
24ZNF263_19887448_ChIP-Seq_K562_Human1.97522066
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.92292768
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.92082543
27ZNF274_21170338_ChIP-Seq_K562_Hela1.91637131
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88075175
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.85236022
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84370617
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.75526761
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.68834286
33DROSHA_22980978_ChIP-Seq_HELA_Human1.68133404
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67112318
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66662039
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65166338
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63442686
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62498663
39VDR_24787735_ChIP-Seq_THP-1_Human1.62248537
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59519309
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58740723
42CTCF_27219007_Chip-Seq_Bcells_Human1.56012692
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54173887
44BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51663157
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50766186
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.45954971
47AR_21572438_ChIP-Seq_LNCaP_Human1.45651307
48* IRF8_27001747_Chip-Seq_BMDM_Mouse1.45542761
49ER_23166858_ChIP-Seq_MCF-7_Human1.44249161
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.41180932
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40549367
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37053255
53SMAD4_21799915_ChIP-Seq_A2780_Human1.36049879
54TP53_16413492_ChIP-PET_HCT116_Human1.35887271
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35648165
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.34559526
57IGF1R_20145208_ChIP-Seq_DFB_Human1.34307483
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32772273
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32577031
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31969149
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.31887520
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.31481919
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31226106
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30176462
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30043631
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30043631
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28580840
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28009137
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27395242
70TAF15_26573619_Chip-Seq_HEK293_Human1.26407991
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25369028
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25077335
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.25053555
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24260119
75SPI1_23127762_ChIP-Seq_K562_Human1.24163793
76FOXH1_21741376_ChIP-Seq_ESCs_Human1.23383135
77* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21724846
78STAT3_23295773_ChIP-Seq_U87_Human1.21254402
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20747139
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20381441
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.20085296
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18551448
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17574460
84* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17476952
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16677500
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16119163
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15957202
88CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15789068
89GATA1_19941826_ChIP-Seq_K562_Human1.15458099
90CREB1_26743006_Chip-Seq_LNCaP_Human1.15285198
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14707262
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.13685637
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.13052586
94OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12914700
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12636423
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12300784
97* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11913896
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11795668
99CLOCK_20551151_ChIP-Seq_293T_Human1.11402211
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11289641
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10656476
102* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10534837
103KDM2B_26808549_Chip-Seq_DND41_Human1.10495392
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10386339
105VDR_22108803_ChIP-Seq_LS180_Human1.09926880
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09866452
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.09626951
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09095365
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08925454
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08375716
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.07988105
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.07487928
113LXR_22292898_ChIP-Seq_THP-1_Human1.06584114
114P300_19829295_ChIP-Seq_ESCs_Human1.06173665
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.06006256
116TCF4_23295773_ChIP-Seq_U87_Human1.05934200
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.05842764
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.05363763
119P53_22387025_ChIP-Seq_ESCs_Mouse1.04122272
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04061809
121OCT4_20526341_ChIP-Seq_ESCs_Human1.03406760
122KDM2B_26808549_Chip-Seq_K562_Human1.03257995
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.03141587
124* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02415137
125RXR_22108803_ChIP-Seq_LS180_Human1.02322430
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01462086
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00633419
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00556241
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.00094757
130KDM2B_26808549_Chip-Seq_REH_Human0.99555944
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.99405198
132GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99221167
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98819948
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98659768
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98147240
136SCL_19346495_ChIP-Seq_HPC-7_Human0.97945399
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97726159
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97726159
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97258745
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96881968
141SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96695802
142TP63_22573176_ChIP-Seq_HFKS_Human0.96643622
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96259678
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96085279
145* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95574326
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95562229
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95194572
148ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94439041
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92454912
150SA1_27219007_Chip-Seq_Bcells_Human0.91628039
151BCAT_22108803_ChIP-Seq_LS180_Human0.91493699
152KLF4_19829295_ChIP-Seq_ESCs_Human0.90731488
153* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90498527
154SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90283575
155NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90040275
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89781161
157PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89557866
158EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89123211
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89100221
160* REST_18959480_ChIP-ChIP_MESCs_Mouse0.88814550
161RUNX1_27514584_Chip-Seq_MCF-7_Human0.87698188
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86731730
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86427123
164WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86375195
165JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86239269
166FOXA2_19822575_ChIP-Seq_HepG2_Human0.85889753
167RAC3_21632823_ChIP-Seq_H3396_Human0.84556455
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.84288566
169DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83992108
170HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83955047
171CTCF_21964334_Chip-Seq_Bcells_Human0.83360801
172RACK7_27058665_Chip-Seq_MCF-7_Human0.83142556
173AR_19668381_ChIP-Seq_PC3_Human0.82091721
174P68_20966046_ChIP-Seq_HELA_Human0.82028992
175* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81232479
176CBP_20019798_ChIP-Seq_JUKART_Human0.80276545
177IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80276545
178SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78947716
179PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78471751
180SMC4_20622854_ChIP-Seq_HELA_Human0.78363768
181ISL1_27105846_Chip-Seq_CPCs_Mouse0.77902417
182P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77783037
183RXR_22158963_ChIP-Seq_LIVER_Mouse0.77760718
184SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77167420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.54613552
2MP0003646_muscle_fatigue5.68178200
3MP0002837_dystrophic_cardiac_calcinosis5.27308072
4MP0000751_myopathy5.14151333
5* MP0000749_muscle_degeneration4.72086415
6MP0004036_abnormal_muscle_relaxation4.27609359
7MP0000569_abnormal_digit_pigmentation4.16433196
8MP0000747_muscle_weakness3.56762519
9MP0002106_abnormal_muscle_physiology3.55309523
10MP0003724_increased_susceptibility_to3.36144449
11MP0004087_abnormal_muscle_fiber3.01133908
12* MP0000759_abnormal_skeletal_muscle2.98534876
13MP0005369_muscle_phenotype2.95199128
14* MP0002269_muscular_atrophy2.91506074
15MP0004130_abnormal_muscle_cell2.87387645
16MP0000750_abnormal_muscle_regeneration2.83054349
17* MP0005620_abnormal_muscle_contractility2.79863640
18MP0004084_abnormal_cardiac_muscle2.79357836
19MP0005451_abnormal_body_composition2.76145833
20MP0004215_abnormal_myocardial_fiber2.36044566
21MP0004043_abnormal_pH_regulation2.34997394
22MP0004233_abnormal_muscle_weight2.28753129
23MP0008260_abnormal_autophagy2.27556540
24MP0005330_cardiomyopathy2.16076320
25MP0003787_abnormal_imprinting2.14965230
26MP0000013_abnormal_adipose_tissue2.11281566
27MP0003283_abnormal_digestive_organ2.09278309
28MP0009780_abnormal_chondrocyte_physiolo1.97119332
29MP0003656_abnormal_erythrocyte_physiolo1.95329889
30MP0002909_abnormal_adrenal_gland1.93856549
31MP0002877_abnormal_melanocyte_morpholog1.93707170
32MP0006036_abnormal_mitochondrial_physio1.76449490
33MP0002972_abnormal_cardiac_muscle1.74978235
34MP0002693_abnormal_pancreas_physiology1.71305444
35MP0002332_abnormal_exercise_endurance1.65904828
36MP0003303_peritoneal_inflammation1.61555385
37MP0002234_abnormal_pharynx_morphology1.57732137
38MP0004381_abnormal_hair_follicle1.57236345
39MP0003195_calcinosis1.56927938
40MP0002108_abnormal_muscle_morphology1.53026512
41MP0004270_analgesia1.52407931
42MP0004185_abnormal_adipocyte_glucose1.48172520
43MP0002078_abnormal_glucose_homeostasis1.44361397
44MP0000733_abnormal_muscle_development1.39977046
45MP0010630_abnormal_cardiac_muscle1.37543743
46MP0003137_abnormal_impulse_conducting1.33874350
47MP0004484_altered_response_of1.33262576
48MP0005666_abnormal_adipose_tissue1.32432438
49MP0001944_abnormal_pancreas_morphology1.31545052
50MP0000015_abnormal_ear_pigmentation1.28481143
51MP0000678_abnormal_parathyroid_gland1.24110206
52MP0005375_adipose_tissue_phenotype1.23522789
53MP0000003_abnormal_adipose_tissue1.22473697
54MP0008961_abnormal_basal_metabolism1.22090580
55MP0005385_cardiovascular_system_phenoty1.20768675
56MP0001544_abnormal_cardiovascular_syste1.20768675
57MP0004883_abnormal_blood_vessel1.19149237
58MP0005174_abnormal_tail_pigmentation1.16325567
59MP0001835_abnormal_antigen_presentation1.10997254
60MP0003221_abnormal_cardiomyocyte_apopto1.10216582
61MP0002277_abnormal_respiratory_mucosa1.09771412
62MP0002132_abnormal_respiratory_system1.06521210
63MP0003121_genomic_imprinting1.05952758
64MP0002971_abnormal_brown_adipose1.04680727
65MP0003122_maternal_imprinting1.03517230
66MP0008775_abnormal_heart_ventricle1.02971024
67MP0002419_abnormal_innate_immunity1.02784664
68MP0004085_abnormal_heartbeat1.02594780
69MP0001800_abnormal_humoral_immune1.01013567
70MP0004142_abnormal_muscle_tone0.98392881
71MP0000427_abnormal_hair_cycle0.95431423
72MP0008877_abnormal_DNA_methylation0.95064399
73MP0005266_abnormal_metabolism0.90357718
74MP0005167_abnormal_blood-brain_barrier0.90045364
75MP0002896_abnormal_bone_mineralization0.89848513
76MP0003436_decreased_susceptibility_to0.88347860
77MP0001958_emphysema0.86014688
78MP0005275_abnormal_skin_tensile0.80862478
79MP0001299_abnormal_eye_distance/0.80826441
80MP0000685_abnormal_immune_system0.78854864
81MP0003172_abnormal_lysosome_physiology0.78847805
82MP0002127_abnormal_cardiovascular_syste0.77821183
83MP0006138_congestive_heart_failure0.77035973
84MP0005670_abnormal_white_adipose0.76771577
85MP0002723_abnormal_immune_serum0.76590846
86MP0006035_abnormal_mitochondrial_morpho0.75326730
87MP0005025_abnormal_response_to0.74162983
88MP0001765_abnormal_ion_homeostasis0.74063564
89MP0005376_homeostasis/metabolism_phenot0.74060766
90MP0009764_decreased_sensitivity_to0.73652502
91MP0000230_abnormal_systemic_arterial0.73292218
92MP0000465_gastrointestinal_hemorrhage0.72510776
93MP0005379_endocrine/exocrine_gland_phen0.71530554
94MP0004510_myositis0.70867143
95MP0003763_abnormal_thymus_physiology0.68948128
96MP0006276_abnormal_autonomic_nervous0.68624035
97MP0005535_abnormal_body_temperature0.67718942
98MP0005164_abnormal_response_to0.67529672
99MP0008004_abnormal_stomach_pH0.66936091
100MP0002420_abnormal_adaptive_immunity0.66819967
101MP0000266_abnormal_heart_morphology0.65908178
102MP0003806_abnormal_nucleotide_metabolis0.65151223
103MP0002067_abnormal_sensory_capabilities0.65098848
104MP0003959_abnormal_lean_body0.64930531
105MP0001819_abnormal_immune_cell0.64505770
106MP0005334_abnormal_fat_pad0.64125296
107MP0006072_abnormal_retinal_apoptosis0.63613542
108MP0002452_abnormal_antigen_presenting0.62949272
109MP0003690_abnormal_glial_cell0.62658657
110MP0003045_fibrosis0.62355530
111MP0005464_abnormal_platelet_physiology0.61581243
112MP0005075_abnormal_melanosome_morpholog0.60901850
113MP0003828_pulmonary_edema0.60209299
114MP0005187_abnormal_penis_morphology0.58605801
115MP0008874_decreased_physiological_sensi0.58247828
116MP0001533_abnormal_skeleton_physiology0.57288845
117MP0002166_altered_tumor_susceptibility0.56873009
118MP0009785_altered_susceptibility_to0.56401786
119MP0005166_decreased_susceptibility_to0.55329198
120MP0003953_abnormal_hormone_level0.52981187
121MP0003633_abnormal_nervous_system0.52143914
122MP0002638_abnormal_pupillary_reflex0.51873493
123MP0001486_abnormal_startle_reflex0.51746690
124MP0005452_abnormal_adipose_tissue0.51146939
125MP0002168_other_aberrant_phenotype0.50063366
126MP0000372_irregular_coat_pigmentation0.49951063
127MP0009672_abnormal_birth_weight0.49565802
128MP0010386_abnormal_urinary_bladder0.49023291
129MP0005595_abnormal_vascular_smooth0.48774516
130MP0001661_extended_life_span0.48420168
131MP0005387_immune_system_phenotype0.48044277
132MP0001790_abnormal_immune_system0.48044277
133MP0002405_respiratory_system_inflammati0.47765666
134MP0004134_abnormal_chest_morphology0.45999825
135MP0003950_abnormal_plasma_membrane0.44198290
136MP0008569_lethality_at_weaning0.44132605
137MP0005083_abnormal_biliary_tract0.43533583
138MP0005220_abnormal_exocrine_pancreas0.42945950
139MP0003705_abnormal_hypodermis_morpholog0.42583062
140MP0005448_abnormal_energy_balance0.40636526
141MP0002118_abnormal_lipid_homeostasis0.37630795
142MP0001270_distended_abdomen0.36961767
143MP0001879_abnormal_lymphatic_vessel0.36323621
144MP0003252_abnormal_bile_duct0.35512907
145MP0003948_abnormal_gas_homeostasis0.34798219
146MP0005165_increased_susceptibility_to0.34656543
147MP0003300_gastrointestinal_ulcer0.34163290
148MP0002089_abnormal_postnatal_growth/wei0.28794947
149MP0005646_abnormal_pituitary_gland0.27252579
150MP0005636_abnormal_mineral_homeostasis0.27203911
151MP0009643_abnormal_urine_homeostasis0.27152792
152MP0004858_abnormal_nervous_system0.26915321
153MP0005257_abnormal_intraocular_pressure0.26222623
154MP0000762_abnormal_tongue_morphology0.26095459
155MP0003879_abnormal_hair_cell0.26081237
156MP0005645_abnormal_hypothalamus_physiol0.25932332
157MP0000462_abnormal_digestive_system0.25840258

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.44936675
2Exercise-induced muscle cramps (HP:0003710)7.72106666
3Muscle fiber inclusion bodies (HP:0100299)7.61300114
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.25530338
5Muscle hypertrophy of the lower extremities (HP:0008968)6.98255689
6Nemaline bodies (HP:0003798)6.68215500
7Calf muscle hypertrophy (HP:0008981)6.39930609
8Type 1 muscle fiber predominance (HP:0003803)5.77588170
9Myoglobinuria (HP:0002913)5.74451543
10Myopathic facies (HP:0002058)5.60489705
11Distal arthrogryposis (HP:0005684)5.41173216
12Difficulty running (HP:0009046)5.20735862
13Muscle fiber splitting (HP:0003555)4.94767252
14Round ear (HP:0100830)4.70355940
15Ulnar deviation of the wrist (HP:0003049)4.67537313
16Hyporeflexia of lower limbs (HP:0002600)4.64237706
17Muscle stiffness (HP:0003552)4.34326425
18Abnormality of the left ventricular outflow tract (HP:0011103)4.28596645
19Subaortic stenosis (HP:0001682)4.28596645
20EMG: myopathic abnormalities (HP:0003458)4.24730295
21Myotonia (HP:0002486)4.24129878
22Abnormality of the calf musculature (HP:0001430)4.23667929
23Rhabdomyolysis (HP:0003201)4.20743907
24Sudden death (HP:0001699)4.04927625
25Increased connective tissue (HP:0009025)4.03077900
26Hyperinsulinemic hypoglycemia (HP:0000825)3.71211149
27Asymmetric septal hypertrophy (HP:0001670)3.70735562
28Calcaneovalgus deformity (HP:0001848)3.62382690
29Absent phalangeal crease (HP:0006109)3.59061721
30Hyperkalemia (HP:0002153)3.53763581
31Difficulty climbing stairs (HP:0003551)3.41539563
32Fetal akinesia sequence (HP:0001989)3.37962838
33Abnormality of skeletal muscle fiber size (HP:0012084)3.33976487
34Deformed tarsal bones (HP:0008119)3.22211490
35Insulin-resistant diabetes mellitus (HP:0000831)3.15238475
36Increased variability in muscle fiber diameter (HP:0003557)3.15133882
37Neck muscle weakness (HP:0000467)3.12817494
38Rimmed vacuoles (HP:0003805)3.08761555
39Hypoglycemic coma (HP:0001325)2.97961607
40Ventricular tachycardia (HP:0004756)2.96418093
41Abnormal finger flexion creases (HP:0006143)2.93712946
42Ketoacidosis (HP:0001993)2.91843218
43Large for gestational age (HP:0001520)2.81213505
44Hyperglycemia (HP:0003074)2.79413891
45Areflexia of lower limbs (HP:0002522)2.74533692
46Malignant hyperthermia (HP:0002047)2.72931596
47EMG: neuropathic changes (HP:0003445)2.69924991
48Frequent falls (HP:0002359)2.67437343
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.66605729
50Optic neuritis (HP:0100653)2.65198606
51Retrobulbar optic neuritis (HP:0100654)2.65198606
52Neoplasm of the heart (HP:0100544)2.64115638
53Shoulder girdle muscle weakness (HP:0003547)2.62659531
54Pelvic girdle muscle weakness (HP:0003749)2.59558057
55Long clavicles (HP:0000890)2.58962088
56Abnormality of the hip-girdle musculature (HP:0001445)2.58836577
57Abnormality of the musculature of the pelvis (HP:0001469)2.58836577
58Orchitis (HP:0100796)2.58065490
59Recurrent bacterial skin infections (HP:0005406)2.53669673
60Abnormality of the neuromuscular junction (HP:0003398)2.50118445
61Fatigable weakness (HP:0003473)2.50118445
62Mildly elevated creatine phosphokinase (HP:0008180)2.48306749
63Hypoglycemic seizures (HP:0002173)2.48162405
64Bundle branch block (HP:0011710)2.47730283
65Metatarsus adductus (HP:0001840)2.44590759
66Hypoplastic ischia (HP:0003175)2.43266700
67Peritonitis (HP:0002586)2.42419841
68Eczematoid dermatitis (HP:0000976)2.41457981
69Proximal amyotrophy (HP:0007126)2.41422392
70Pancreatic islet-cell hyperplasia (HP:0004510)2.41073964
71Gastrointestinal infarctions (HP:0005244)2.40899516
72Late onset (HP:0003584)2.37859472
73Myositis (HP:0100614)2.35342575
74Abnormality of the calcaneus (HP:0008364)2.34268958
75Hypokalemia (HP:0002900)2.32363083
76Abnormality of potassium homeostasis (HP:0011042)2.28265924
77Prolonged QT interval (HP:0001657)2.24192742
78Palpitations (HP:0001962)2.24058038
79Muscular dystrophy (HP:0003560)2.23743422
80Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22487274
81Spontaneous hematomas (HP:0007420)2.20495856
82Hip contracture (HP:0003273)2.19967836
83Abnormality of the ischium (HP:0003174)2.16319696
84Abnormality of the foot musculature (HP:0001436)2.16211321
85Keratoconjunctivitis sicca (HP:0001097)2.16169073
86Progressive muscle weakness (HP:0003323)2.14206249
87Dilated cardiomyopathy (HP:0001644)2.12622411
88Lipoatrophy (HP:0100578)2.12472589
89Weak cry (HP:0001612)2.12018182
90Foot dorsiflexor weakness (HP:0009027)2.11631496
91Recurrent abscess formation (HP:0002722)2.09994911
92Symptomatic seizures (HP:0011145)2.07980765
93Abnormality of the pancreatic islet cells (HP:0006476)2.07230951
94Abnormality of endocrine pancreas physiology (HP:0012093)2.07230951
95Postural instability (HP:0002172)2.05523782
96Mask-like facies (HP:0000298)2.03669361
97Gowers sign (HP:0003391)2.02777826
98Chest pain (HP:0100749)2.01323102
99Distal lower limb muscle weakness (HP:0009053)2.00605613
100T lymphocytopenia (HP:0005403)1.99684934
101Keratoconjunctivitis (HP:0001096)1.98753006
102Generalized muscle weakness (HP:0003324)1.98014762
103Limb-girdle muscle weakness (HP:0003325)1.97120047
104Limb-girdle muscle atrophy (HP:0003797)1.96876126
105Abnormality of T cell number (HP:0011839)1.93862701
106Facial diplegia (HP:0001349)1.93312881
107Heart block (HP:0012722)1.92949053
108Gout (HP:0001997)1.88938228
109Gingival bleeding (HP:0000225)1.88905613
110Type 2 muscle fiber atrophy (HP:0003554)1.88743618
111Ventricular arrhythmia (HP:0004308)1.88045126
112Ketosis (HP:0001946)1.87903969
113Popliteal pterygium (HP:0009756)1.87683540
114Centrally nucleated skeletal muscle fibers (HP:0003687)1.87570080
115Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86978843
116Right ventricular cardiomyopathy (HP:0011663)1.86098128
117Paralysis (HP:0003470)1.84848880
118Scapular winging (HP:0003691)1.84302965
119Toxemia of pregnancy (HP:0100603)1.84213790
120Stomatitis (HP:0010280)1.83063699
121Hypochromic microcytic anemia (HP:0004840)1.82794323
122Atrial fibrillation (HP:0005110)1.82297595
123Abnormal atrioventricular conduction (HP:0005150)1.79991038
124Ventricular fibrillation (HP:0001663)1.78921459
125Febrile seizures (HP:0002373)1.77493619
126Spinal rigidity (HP:0003306)1.76261238
127Syncope (HP:0001279)1.75989567
128Nonprogressive disorder (HP:0003680)1.70507595
129Abnormality of the shoulder girdle musculature (HP:0001435)1.70001041
130Primary atrial arrhythmia (HP:0001692)1.69880162
131Insulin resistance (HP:0000855)1.69862049
132Bulbar palsy (HP:0001283)1.69638031
133Papillary thyroid carcinoma (HP:0002895)1.69395789
134Slender build (HP:0001533)1.68262702
135Left ventricular hypertrophy (HP:0001712)1.68027471
136Abnormality of the endocardium (HP:0004306)1.66931721
137Arterial thrombosis (HP:0004420)1.66500067
138Ulnar deviation of finger (HP:0009465)1.62640021
139Breech presentation (HP:0001623)1.58675806
140Gingivitis (HP:0000230)1.56692424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.79371068
2TTN5.80657371
3PHKG25.26632368
4PHKG15.26632368
5INSRR3.67452354
6PIK3CG2.92844427
7NME12.83028635
8BLK2.24757432
9TRIB32.22301521
10PDK42.18479391
11PDK32.18479391
12MAP2K32.04455474
13DMPK1.88436861
14PINK11.88248763
15PASK1.87073916
16NEK11.81632985
17RIPK41.79013754
18BCKDK1.71537409
19IRAK41.70090688
20MAP3K71.69888628
21PTK2B1.61276335
22PIK3CA1.59253302
23PRKD31.53639947
24SGK21.44440013
25FGR1.42382024
26GRK61.39060485
27CSK1.36586440
28IRAK11.29339546
29KSR11.27347293
30PDK21.24447925
31IKBKE1.22547255
32MUSK1.22399551
33MAPK151.21434528
34MARK21.21258698
35HIPK21.21001426
36MARK11.20993663
37MAP2K41.15941741
38MAPK121.14163277
39MAP3K11.13639170
40PRKAA11.10225299
41FGFR31.09031757
42RAF11.08841522
43TAOK31.05696976
44MAPK131.04326620
45TYK21.02248544
46SYK1.01573400
47FES0.99959061
48TXK0.99328024
49ZAP700.97774904
50PRKAA20.96046255
51MAP2K60.93232745
52CAMK40.90271545
53GRK50.89573923
54ERN10.88654069
55PKN20.88437906
56FLT30.88301176
57MAP3K60.88132804
58HCK0.87621726
59MAP3K30.87301437
60PDGFRA0.85567129
61SIK10.84563981
62IRAK20.84553322
63TNK20.83759314
64MAP3K20.83150143
65CCNB10.83012909
66PTK60.82309091
67STK240.80783958
68DYRK1A0.77999655
69JAK30.76067498
70YES10.75802666
71SGK2230.73112584
72SGK4940.73112584
73WNK40.70776068
74RIPK10.70418710
75PLK20.68716556
76TAOK10.66857121
77PRKCH0.65743620
78CDC42BPA0.65686119
79PRKD10.65530887
80MAPKAPK30.65434679
81CAMK2D0.64376410
82MAPK70.63324003
83ADRBK10.61117471
84MARK30.60526441
85NLK0.60358078
86PAK30.60267360
87MAP4K10.59685408
88BTK0.59339446
89TIE10.58262866
90STK40.58079620
91LYN0.57296619
92FRK0.56538129
93MOS0.55181135
94DAPK20.54439089
95NEK90.54096018
96LMTK20.54076745
97CAMKK20.54058479
98TEC0.53022122
99FGFR20.51810682
100ACVR1B0.49862505
101KSR20.49309066
102DYRK1B0.49282986
103EPHB10.48594530
104ERBB20.47986932
105CAMK10.47759661
106CAMK2G0.47539968
107WNK10.45142981
108NTRK10.43561292
109WNK30.43127231
110GRK70.42403311
111MAP3K100.39920112
112PRKACA0.38046059
113MAPK110.37642236
114ERBB30.37119690
115UHMK10.36836944
116MAP3K50.36565490
117TGFBR20.36317097
118SGK10.36200763
119DYRK30.35840323
120PRKD20.35129562
121CASK0.35106127
122ILK0.34945522
123RPS6KA30.34635377
124LCK0.34531907
125NTRK30.34042035
126JAK20.33530236
127CAMK1G0.33303080
128OXSR10.32587869
129PRKACG0.32381422
130AKT30.32192545
131ZAK0.32025238
132RET0.29900562
133TRPM70.29687154
134ROCK10.28862041
135PRKACB0.27893718
136PRKG10.27877557
137PDPK10.27780148
138RPS6KA20.27768705
139PAK60.27617340
140PTK20.27053629
141AKT20.25448766
142SCYL20.24347817
143MTOR0.23854304
144MYLK0.23838919
145LATS10.21800507
146MAP2K20.21484179
147FER0.21454766
148EPHA30.20663977
149SGK30.19452206
150PKN10.19225892
151PDK10.18846842
152MAP3K110.17702656
153CAMK2A0.16693730
154MAP2K10.16521471
155STK110.15391859
156JAK10.14502123

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.72277782
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.35098517
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.20629409
4Cardiac muscle contraction_Homo sapiens_hsa042602.95465944
5Dilated cardiomyopathy_Homo sapiens_hsa054142.89170776
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.62301545
7Insulin secretion_Homo sapiens_hsa049112.42384040
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25235982
9Glucagon signaling pathway_Homo sapiens_hsa049222.25020345
10Starch and sucrose metabolism_Homo sapiens_hsa005002.13414776
11Type II diabetes mellitus_Homo sapiens_hsa049302.09504368
12Insulin resistance_Homo sapiens_hsa049312.00585850
13Circadian rhythm_Homo sapiens_hsa047101.95968635
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78185708
15Insulin signaling pathway_Homo sapiens_hsa049101.77290082
16Osteoclast differentiation_Homo sapiens_hsa043801.72062843
17Propanoate metabolism_Homo sapiens_hsa006401.70446104
18Sulfur metabolism_Homo sapiens_hsa009201.64179190
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54626839
20Leishmaniasis_Homo sapiens_hsa051401.54594413
21Protein export_Homo sapiens_hsa030601.54072011
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50983049
23Tuberculosis_Homo sapiens_hsa051521.50649509
24Oxytocin signaling pathway_Homo sapiens_hsa049211.50035656
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49425426
26Alzheimers disease_Homo sapiens_hsa050101.48750508
27Platelet activation_Homo sapiens_hsa046111.44551311
28Galactose metabolism_Homo sapiens_hsa000521.43114108
29Fatty acid degradation_Homo sapiens_hsa000711.42602533
30Parkinsons disease_Homo sapiens_hsa050121.41026639
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39078582
32Non-small cell lung cancer_Homo sapiens_hsa052231.37639862
33Carbon metabolism_Homo sapiens_hsa012001.36228974
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36182146
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34319577
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.33819042
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32714811
38AMPK signaling pathway_Homo sapiens_hsa041521.30619784
39B cell receptor signaling pathway_Homo sapiens_hsa046621.30534658
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27816679
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27532093
42Calcium signaling pathway_Homo sapiens_hsa040201.26341948
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26042322
44Oxidative phosphorylation_Homo sapiens_hsa001901.25971722
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24803350
46Malaria_Homo sapiens_hsa051441.21645414
47Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20832190
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19908775
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15901228
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.13386527
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11945577
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.07931866
53Glioma_Homo sapiens_hsa052141.07630004
54Endometrial cancer_Homo sapiens_hsa052131.05473812
55Chemokine signaling pathway_Homo sapiens_hsa040621.05438706
56Legionellosis_Homo sapiens_hsa051341.04968065
57T cell receptor signaling pathway_Homo sapiens_hsa046601.04149559
58Staphylococcus aureus infection_Homo sapiens_hsa051500.98877839
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.98816933
60Fatty acid metabolism_Homo sapiens_hsa012120.97802787
61Acute myeloid leukemia_Homo sapiens_hsa052210.97364069
62Nitrogen metabolism_Homo sapiens_hsa009100.97078687
63Renin secretion_Homo sapiens_hsa049240.95417567
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.95257592
65Fructose and mannose metabolism_Homo sapiens_hsa000510.95229278
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94197071
67Gastric acid secretion_Homo sapiens_hsa049710.93689845
68Pyruvate metabolism_Homo sapiens_hsa006200.92881264
69Pancreatic secretion_Homo sapiens_hsa049720.92796671
70Olfactory transduction_Homo sapiens_hsa047400.91257517
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90299431
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89017107
73Measles_Homo sapiens_hsa051620.85702366
74Butanoate metabolism_Homo sapiens_hsa006500.83797635
75Toxoplasmosis_Homo sapiens_hsa051450.83497571
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82538198
77Type I diabetes mellitus_Homo sapiens_hsa049400.80630968
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80246562
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80186798
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79079364
81GnRH signaling pathway_Homo sapiens_hsa049120.77972246
82Circadian entrainment_Homo sapiens_hsa047130.77624828
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77062297
84Viral myocarditis_Homo sapiens_hsa054160.76296374
85Notch signaling pathway_Homo sapiens_hsa043300.75353139
86mTOR signaling pathway_Homo sapiens_hsa041500.75173180
87Inositol phosphate metabolism_Homo sapiens_hsa005620.74719664
88Morphine addiction_Homo sapiens_hsa050320.74013653
89Cholinergic synapse_Homo sapiens_hsa047250.73546371
90ErbB signaling pathway_Homo sapiens_hsa040120.73508779
91Long-term potentiation_Homo sapiens_hsa047200.72390509
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70920577
93Choline metabolism in cancer_Homo sapiens_hsa052310.69403458
94TNF signaling pathway_Homo sapiens_hsa046680.69081692
95Tight junction_Homo sapiens_hsa045300.68842690
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.68177620
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.65952397
98Huntingtons disease_Homo sapiens_hsa050160.64588429
99Pancreatic cancer_Homo sapiens_hsa052120.64571893
100Arginine and proline metabolism_Homo sapiens_hsa003300.61692504
101Amphetamine addiction_Homo sapiens_hsa050310.61603423
102Focal adhesion_Homo sapiens_hsa045100.61495700
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60527196
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59991167
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.59977915
106Amoebiasis_Homo sapiens_hsa051460.57957602
107Hepatitis B_Homo sapiens_hsa051610.57668451
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56543237
109FoxO signaling pathway_Homo sapiens_hsa040680.55905791
110Tryptophan metabolism_Homo sapiens_hsa003800.55854497
111Hepatitis C_Homo sapiens_hsa051600.55291818
112Influenza A_Homo sapiens_hsa051640.54826671
113Cocaine addiction_Homo sapiens_hsa050300.53881667
114Biosynthesis of amino acids_Homo sapiens_hsa012300.53836084
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53401986
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52538441
117Chronic myeloid leukemia_Homo sapiens_hsa052200.52017712
118ABC transporters_Homo sapiens_hsa020100.51016249
119Lysine degradation_Homo sapiens_hsa003100.49511994
120Prolactin signaling pathway_Homo sapiens_hsa049170.49101570
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49096585
122Dopaminergic synapse_Homo sapiens_hsa047280.47053089
123Dorso-ventral axis formation_Homo sapiens_hsa043200.46924143
124cAMP signaling pathway_Homo sapiens_hsa040240.46863464
125GABAergic synapse_Homo sapiens_hsa047270.45425243
126Fat digestion and absorption_Homo sapiens_hsa049750.44752673
127Taste transduction_Homo sapiens_hsa047420.44731422
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43960430
129MAPK signaling pathway_Homo sapiens_hsa040100.43065705
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40706987
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40293638
132Regulation of autophagy_Homo sapiens_hsa041400.40236105
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36383543
134Estrogen signaling pathway_Homo sapiens_hsa049150.35887910
135Vibrio cholerae infection_Homo sapiens_hsa051100.35114856
136Renal cell carcinoma_Homo sapiens_hsa052110.34055561
137Fatty acid elongation_Homo sapiens_hsa000620.32727585
138Melanogenesis_Homo sapiens_hsa049160.32609652
139VEGF signaling pathway_Homo sapiens_hsa043700.32305806
140Selenocompound metabolism_Homo sapiens_hsa004500.31070133
141Gap junction_Homo sapiens_hsa045400.30521652
142Phenylalanine metabolism_Homo sapiens_hsa003600.30430083
143Thyroid hormone synthesis_Homo sapiens_hsa049180.29494857
144Serotonergic synapse_Homo sapiens_hsa047260.26890206
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25444731
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25125042
147Long-term depression_Homo sapiens_hsa047300.25062984
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24762101
149Salivary secretion_Homo sapiens_hsa049700.24225612
150Adherens junction_Homo sapiens_hsa045200.22107527

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