KYAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15595394
2regulation of mitochondrial translation (GO:0070129)4.09299202
3DNA double-strand break processing (GO:0000729)3.89532268
4establishment of integrated proviral latency (GO:0075713)3.73921927
5cullin deneddylation (GO:0010388)3.70846286
6protein deneddylation (GO:0000338)3.50488354
7ATP synthesis coupled proton transport (GO:0015986)3.45726041
8energy coupled proton transport, down electrochemical gradient (GO:0015985)3.45726041
9DNA strand elongation involved in DNA replication (GO:0006271)3.44626747
10L-serine metabolic process (GO:0006563)3.44246394
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34114648
12C4-dicarboxylate transport (GO:0015740)3.33463810
13telomere maintenance via semi-conservative replication (GO:0032201)3.29712713
14DNA strand elongation (GO:0022616)3.26936358
15kinetochore assembly (GO:0051382)3.23265004
16termination of RNA polymerase III transcription (GO:0006386)3.20271944
17transcription elongation from RNA polymerase III promoter (GO:0006385)3.20271944
18proteasome assembly (GO:0043248)3.18193589
19oxidative phosphorylation (GO:0006119)3.17125923
20chaperone-mediated protein transport (GO:0072321)3.16667074
21respiratory electron transport chain (GO:0022904)3.13587950
22histone H2A acetylation (GO:0043968)3.09951716
23protein complex biogenesis (GO:0070271)3.06395808
24establishment of viral latency (GO:0019043)3.06384791
25mitochondrial respiratory chain complex assembly (GO:0033108)3.05686457
26electron transport chain (GO:0022900)3.05635137
27DNA replication checkpoint (GO:0000076)3.03988424
28peptidyl-arginine methylation (GO:0018216)2.97363619
29peptidyl-arginine N-methylation (GO:0035246)2.97363619
30peptidyl-arginine omega-N-methylation (GO:0035247)2.92265005
31kinetochore organization (GO:0051383)2.87844119
32chromatin remodeling at centromere (GO:0031055)2.83319130
33spliceosomal snRNP assembly (GO:0000387)2.82581414
34DNA damage response, detection of DNA damage (GO:0042769)2.81091983
35somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80136544
36somatic hypermutation of immunoglobulin genes (GO:0016446)2.80136544
37DNA ligation (GO:0006266)2.79327779
38DNA catabolic process, exonucleolytic (GO:0000738)2.76626700
39presynaptic membrane assembly (GO:0097105)2.75231037
40nucleotide-excision repair, DNA gap filling (GO:0006297)2.75003303
41establishment of protein localization to mitochondrial membrane (GO:0090151)2.74922094
42CENP-A containing nucleosome assembly (GO:0034080)2.74663480
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.73591964
44NADH dehydrogenase complex assembly (GO:0010257)2.73591964
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73591964
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72382593
47viral mRNA export from host cell nucleus (GO:0046784)2.71867521
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70426024
49replication fork processing (GO:0031297)2.69246894
50telomere maintenance via recombination (GO:0000722)2.68880394
51inner mitochondrial membrane organization (GO:0007007)2.68601918
52mitotic recombination (GO:0006312)2.67895587
53mitotic sister chromatid segregation (GO:0000070)2.67462932
54histone arginine methylation (GO:0034969)2.67408126
55regulation of mitotic spindle checkpoint (GO:1903504)2.64611425
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64611425
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64108830
58peptidyl-histidine modification (GO:0018202)2.62096161
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61764574
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.61516956
61postsynaptic membrane organization (GO:0001941)2.60436490
62glyoxylate metabolic process (GO:0046487)2.59151150
63pyrimidine nucleobase catabolic process (GO:0006208)2.58643356
64glycine metabolic process (GO:0006544)2.58499615
65lysine catabolic process (GO:0006554)2.58072715
66lysine metabolic process (GO:0006553)2.58072715
67purine nucleobase biosynthetic process (GO:0009113)2.57959929
68rRNA modification (GO:0000154)2.57829043
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.54018189
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53327716
71base-excision repair (GO:0006284)2.53118264
72transcription-coupled nucleotide-excision repair (GO:0006283)2.52773031
73transcription from mitochondrial promoter (GO:0006390)2.50213634
74regulation of double-strand break repair via homologous recombination (GO:0010569)2.49109133
75serine family amino acid biosynthetic process (GO:0009070)2.48980292
76amino acid salvage (GO:0043102)2.48341242
77L-methionine salvage (GO:0071267)2.48341242
78L-methionine biosynthetic process (GO:0071265)2.48341242
79water-soluble vitamin biosynthetic process (GO:0042364)2.47305159
80protein-cofactor linkage (GO:0018065)2.47270266
81presynaptic membrane organization (GO:0097090)2.46864928
82base-excision repair, AP site formation (GO:0006285)2.46815182
83aspartate family amino acid catabolic process (GO:0009068)2.46375710
84cytochrome complex assembly (GO:0017004)2.45001673
85ubiquinone metabolic process (GO:0006743)2.44610771
86mitochondrial RNA metabolic process (GO:0000959)2.44391667
87DNA replication-independent nucleosome assembly (GO:0006336)2.43874063
88DNA replication-independent nucleosome organization (GO:0034724)2.43874063
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.43388157
90neuron cell-cell adhesion (GO:0007158)2.42343902
91spindle checkpoint (GO:0031577)2.42034531
92protein K6-linked ubiquitination (GO:0085020)2.41573486
93negative regulation of DNA recombination (GO:0045910)2.39656628
94protein localization to kinetochore (GO:0034501)2.39503640
95ubiquinone biosynthetic process (GO:0006744)2.39304259
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38382118
97regulation of translational fidelity (GO:0006450)2.38033267
98protein targeting to mitochondrion (GO:0006626)2.37854486
99histone exchange (GO:0043486)2.37632048
100ribosomal small subunit assembly (GO:0000028)2.37058864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.59338596
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59191534
3E2F7_22180533_ChIP-Seq_HELA_Human4.45608241
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73495321
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.57330938
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.40242903
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18431900
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03830707
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95585919
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95304204
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.90494424
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90041897
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.87278746
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70901754
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68387041
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66664126
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.64930498
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55858226
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.54420923
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35297032
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.30684061
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.24927272
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23896166
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11261953
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.06244315
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05084688
27ELK1_19687146_ChIP-ChIP_HELA_Human2.01641967
28VDR_23849224_ChIP-Seq_CD4+_Human2.01608050
29GABP_19822575_ChIP-Seq_HepG2_Human1.93051837
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92653089
31XRN2_22483619_ChIP-Seq_HELA_Human1.90365459
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84207608
33DCP1A_22483619_ChIP-Seq_HELA_Human1.83755191
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81563652
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.79885286
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.76482960
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76440722
38TTF2_22483619_ChIP-Seq_HELA_Human1.76006718
39ZNF274_21170338_ChIP-Seq_K562_Hela1.75734857
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74153516
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73759012
42MYC_18940864_ChIP-ChIP_HL60_Human1.69269043
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62704758
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57062261
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52677332
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42351369
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41070542
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40506693
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40322975
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37761673
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33138451
52IGF1R_20145208_ChIP-Seq_DFB_Human1.31998505
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31625546
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.30956227
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.28820709
56KDM5A_27292631_Chip-Seq_BREAST_Human1.14987233
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14614959
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10910173
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10489410
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04206561
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04027167
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03622886
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02607432
64CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01980111
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99481392
66ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98811446
67NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98368125
68IRF1_19129219_ChIP-ChIP_H3396_Human0.97164547
69NANOG_16153702_ChIP-ChIP_HESCs_Human0.96306467
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96182341
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94915220
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93725943
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90519154
74CIITA_25753668_ChIP-Seq_RAJI_Human0.90417781
75SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89971118
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89364511
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88930697
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88821811
79FUS_26573619_Chip-Seq_HEK293_Human0.88505551
80CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87921264
81REST_18959480_ChIP-ChIP_MESCs_Mouse0.87233881
82EZH2_22144423_ChIP-Seq_EOC_Human0.86803055
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84580706
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84521443
85TP53_22573176_ChIP-Seq_HFKS_Human0.83625200
86HTT_18923047_ChIP-ChIP_STHdh_Human0.83534465
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.82785832
88EWS_26573619_Chip-Seq_HEK293_Human0.82752278
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81861567
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80834016
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.78958542
92GBX2_23144817_ChIP-Seq_PC3_Human0.76419618
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75256808
94VDR_22108803_ChIP-Seq_LS180_Human0.74593399
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74365940
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74306973
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73796268
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73538790
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.71031553
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70594977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.07583359
2MP0010094_abnormal_chromosome_stability2.87183353
3MP0008058_abnormal_DNA_repair2.78232550
4MP0003122_maternal_imprinting2.70580890
5MP0003111_abnormal_nucleus_morphology2.43202877
6MP0002736_abnormal_nociception_after2.18512743
7MP0006292_abnormal_olfactory_placode2.16431915
8MP0001968_abnormal_touch/_nociception2.07054218
9MP0001529_abnormal_vocalization1.99275066
10MP0005423_abnormal_somatic_nervous1.97318760
11MP0003693_abnormal_embryo_hatching1.91650633
12MP0003786_premature_aging1.90278899
13MP0008932_abnormal_embryonic_tissue1.90190008
14MP0006276_abnormal_autonomic_nervous1.90136276
15MP0001984_abnormal_olfaction1.87405926
16MP0009046_muscle_twitch1.85862533
17MP0002102_abnormal_ear_morphology1.85236035
18MP0003121_genomic_imprinting1.84858706
19MP0008877_abnormal_DNA_methylation1.73424883
20MP0004957_abnormal_blastocyst_morpholog1.69863212
21MP0003195_calcinosis1.65983278
22MP0005645_abnormal_hypothalamus_physiol1.64424974
23MP0006035_abnormal_mitochondrial_morpho1.63904414
24MP0008789_abnormal_olfactory_epithelium1.62602775
25MP0005499_abnormal_olfactory_system1.57870123
26MP0005394_taste/olfaction_phenotype1.57870123
27MP0001293_anophthalmia1.57851612
28MP0004270_analgesia1.52597190
29MP0009697_abnormal_copulation1.50009282
30MP0002938_white_spotting1.47409869
31MP0003136_yellow_coat_color1.46718574
32MP0006036_abnormal_mitochondrial_physio1.44951087
33MP0003283_abnormal_digestive_organ1.44728911
34MP0010030_abnormal_orbit_morphology1.44511517
35MP0005551_abnormal_eye_electrophysiolog1.40758756
36MP0008995_early_reproductive_senescence1.38831078
37MP0000372_irregular_coat_pigmentation1.38816565
38MP0004859_abnormal_synaptic_plasticity1.37278537
39MP0002234_abnormal_pharynx_morphology1.34858429
40MP0003077_abnormal_cell_cycle1.33354912
41MP0002064_seizures1.32941066
42MP0002837_dystrophic_cardiac_calcinosis1.31581278
43MP0000778_abnormal_nervous_system1.28072119
44MP0004133_heterotaxia1.26563434
45MP0002272_abnormal_nervous_system1.26529556
46MP0001764_abnormal_homeostasis1.25745385
47MP0001486_abnormal_startle_reflex1.25358124
48MP0003718_maternal_effect1.24339823
49MP0004142_abnormal_muscle_tone1.22620575
50MP0002734_abnormal_mechanical_nocicepti1.22064362
51MP0003806_abnormal_nucleotide_metabolis1.19368320
52MP0009745_abnormal_behavioral_response1.19315283
53MP0005360_urolithiasis1.19295099
54MP0004147_increased_porphyrin_level1.17733955
55MP0003890_abnormal_embryonic-extraembry1.16915304
56MP0003635_abnormal_synaptic_transmissio1.16759579
57MP0003123_paternal_imprinting1.16301573
58MP0002653_abnormal_ependyma_morphology1.13565341
59MP0008875_abnormal_xenobiotic_pharmacok1.10930203
60MP0008007_abnormal_cellular_replicative1.10576276
61MP0003186_abnormal_redox_activity1.10498332
62MP0002751_abnormal_autonomic_nervous1.09834860
63MP0000358_abnormal_cell_content/1.08587801
64MP0000631_abnormal_neuroendocrine_gland1.05284932
65MP0003119_abnormal_digestive_system1.04828330
66MP0003937_abnormal_limbs/digits/tail_de1.04625913
67MP0000955_abnormal_spinal_cord1.03713622
68MP0005365_abnormal_bile_salt1.02774798
69MP0005187_abnormal_penis_morphology1.01513946
70MP0002572_abnormal_emotion/affect_behav1.01312647
71MP0002233_abnormal_nose_morphology1.01037519
72MP0002735_abnormal_chemical_nociception0.99787728
73MP0003787_abnormal_imprinting0.98984498
74MP0005253_abnormal_eye_physiology0.98872399
75MP0001929_abnormal_gametogenesis0.97889345
76MP0006072_abnormal_retinal_apoptosis0.97027727
77MP0003698_abnormal_male_reproductive0.96838792
78MP0002067_abnormal_sensory_capabilities0.94790028
79MP0002557_abnormal_social/conspecific_i0.94732132
80MP0005085_abnormal_gallbladder_physiolo0.93874248
81MP0002210_abnormal_sex_determination0.92473762
82MP0002063_abnormal_learning/memory/cond0.91620316
83MP0003861_abnormal_nervous_system0.89935620
84MP0004145_abnormal_muscle_electrophysio0.88909284
85MP0002184_abnormal_innervation0.87853577
86MP0003646_muscle_fatigue0.86603908
87MP0003137_abnormal_impulse_conducting0.86072295
88MP0000653_abnormal_sex_gland0.84881463
89MP0008872_abnormal_physiological_respon0.84784939
90MP0002752_abnormal_somatic_nervous0.84288135
91MP0005332_abnormal_amino_acid0.83831440
92MP0002697_abnormal_eye_size0.81687689
93MP0002733_abnormal_thermal_nociception0.80852042
94MP0001145_abnormal_male_reproductive0.79410552
95MP0002882_abnormal_neuron_morphology0.78649797
96MP0002822_catalepsy0.78389949
97MP0005391_vision/eye_phenotype0.77968944
98MP0005646_abnormal_pituitary_gland0.77285818
99MP0003011_delayed_dark_adaptation0.77222281
100MP0002152_abnormal_brain_morphology0.76186862

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.88432383
2Acute encephalopathy (HP:0006846)3.85081039
3Abnormal mitochondria in muscle tissue (HP:0008316)3.69208596
4Hyperglycinemia (HP:0002154)3.36821815
5Mitochondrial inheritance (HP:0001427)3.28250392
6Progressive macrocephaly (HP:0004481)3.26643402
7Increased CSF lactate (HP:0002490)3.19267764
8Hepatocellular necrosis (HP:0001404)3.11085766
9Increased serum pyruvate (HP:0003542)3.07015050
10Abnormality of glycolysis (HP:0004366)3.05400219
11Cerebral edema (HP:0002181)2.93056057
12Hepatic necrosis (HP:0002605)2.91028717
13Abnormal gallbladder physiology (HP:0012438)2.89587266
14Cholecystitis (HP:0001082)2.89587266
15Abnormality of the labia minora (HP:0012880)2.83178615
16Retinal dysplasia (HP:0007973)2.75340828
17Cerebral hypomyelination (HP:0006808)2.62004622
18Abnormal number of erythroid precursors (HP:0012131)2.56147722
19Microvesicular hepatic steatosis (HP:0001414)2.53886678
20Increased serum lactate (HP:0002151)2.46042928
21Reticulocytopenia (HP:0001896)2.44220067
22Methylmalonic aciduria (HP:0012120)2.43252997
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.41527614
24Meckel diverticulum (HP:0002245)2.40000043
25Lactic acidosis (HP:0003128)2.37142271
26Chromsome breakage (HP:0040012)2.37038073
27Medial flaring of the eyebrow (HP:0010747)2.35472941
28Abnormality of the ileum (HP:0001549)2.31311629
29Abnormality of serum amino acid levels (HP:0003112)2.30785896
30Increased hepatocellular lipid droplets (HP:0006565)2.29708398
31Abnormal lung lobation (HP:0002101)2.25811795
32Pancreatic fibrosis (HP:0100732)2.25188646
33Cortical dysplasia (HP:0002539)2.22176413
34Hypothermia (HP:0002045)2.20258344
35Abnormality of chromosome stability (HP:0003220)2.19813692
363-Methylglutaconic aciduria (HP:0003535)2.19261267
37Colon cancer (HP:0003003)2.18297116
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.16676432
39Exercise intolerance (HP:0003546)2.14414272
40Myokymia (HP:0002411)2.13083323
41Gait imbalance (HP:0002141)2.12813288
42Lipid accumulation in hepatocytes (HP:0006561)2.11305769
43Abnormality of serine family amino acid metabolism (HP:0010894)2.11086675
44Abnormality of glycine metabolism (HP:0010895)2.11086675
45Anophthalmia (HP:0000528)2.10361274
46Abnormality of cells of the erythroid lineage (HP:0012130)2.07865720
47Pancreatic cysts (HP:0001737)2.05166159
48True hermaphroditism (HP:0010459)2.05059404
49Congenital primary aphakia (HP:0007707)2.04035831
50Hypoplastic pelvis (HP:0008839)2.00783129
51Leukodystrophy (HP:0002415)2.00123805
52Optic disc pallor (HP:0000543)1.99387813
53Prolonged partial thromboplastin time (HP:0003645)1.97898395
54CNS hypomyelination (HP:0003429)1.97642135
55Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96520801
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.95370862
57Decreased activity of mitochondrial respiratory chain (HP:0008972)1.95370862
58Sclerocornea (HP:0000647)1.94371199
59Respiratory failure (HP:0002878)1.91110200
60Type II lissencephaly (HP:0007260)1.90753266
61Bile duct proliferation (HP:0001408)1.88886360
62Abnormal biliary tract physiology (HP:0012439)1.88886360
63Limb dystonia (HP:0002451)1.88386847
64Ependymoma (HP:0002888)1.87900904
65Duodenal stenosis (HP:0100867)1.86876091
66Small intestinal stenosis (HP:0012848)1.86876091
67Abnormality of the preputium (HP:0100587)1.86853606
68Postaxial foot polydactyly (HP:0001830)1.85933731
69Lethargy (HP:0001254)1.84522450
70Nephrogenic diabetes insipidus (HP:0009806)1.83983576
71Bilateral microphthalmos (HP:0007633)1.83325446
72Preaxial hand polydactyly (HP:0001177)1.83292365
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83031396
74Abnormality of alanine metabolism (HP:0010916)1.83031396
75Hyperalaninemia (HP:0003348)1.83031396
76Oligodactyly (hands) (HP:0001180)1.82922921
77Hyperglycinuria (HP:0003108)1.82416283
78Abnormality of the duodenum (HP:0002246)1.81379841
79Abnormal protein glycosylation (HP:0012346)1.80841666
80Abnormal glycosylation (HP:0012345)1.80841666
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80841666
82Abnormal protein N-linked glycosylation (HP:0012347)1.80841666
83Vaginal atresia (HP:0000148)1.80099677
84Genital tract atresia (HP:0001827)1.79613602
85Emotional lability (HP:0000712)1.78952910
86Type I transferrin isoform profile (HP:0003642)1.78772996
87Occipital encephalocele (HP:0002085)1.78179606
88Sloping forehead (HP:0000340)1.76972051
89Poikiloderma (HP:0001029)1.76600184
90Abnormality of methionine metabolism (HP:0010901)1.75977229
91Focal motor seizures (HP:0011153)1.74084351
92Hypoglycemic coma (HP:0001325)1.73378281
93Increased intramyocellular lipid droplets (HP:0012240)1.72852034
94Hypobetalipoproteinemia (HP:0003563)1.72069114
95Synostosis involving the elbow (HP:0003938)1.71782178
96Humeroradial synostosis (HP:0003041)1.71782178
97Abnormality of DNA repair (HP:0003254)1.71767849
98Methylmalonic acidemia (HP:0002912)1.70922021
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70715437
100Triphalangeal thumb (HP:0001199)1.68121244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.25354685
2NEK13.39100942
3MAP4K23.11298814
4VRK22.90891672
5CDC72.36157444
6MAP3K42.34530364
7BCKDK2.31278573
8ZAK2.29633460
9TRIM282.22670965
10MAP2K72.15765441
11TTK1.94664249
12WNK31.93822565
13SRPK11.90305141
14EPHA41.82893847
15MARK11.82336091
16PLK31.81886620
17MAP3K121.80981222
18PDK21.80702200
19CCNB11.76851171
20VRK11.72512919
21DYRK21.69705931
22STK161.63322780
23CDK191.61002297
24NME11.56651789
25TLK11.54335163
26BMPR1B1.52643795
27CDK81.52363058
28TESK21.52054211
29CASK1.51904466
30MAP2K41.49109694
31CSNK1G31.44519644
32MAPK131.44376094
33BRSK11.43730469
34PLK11.42052246
35ATR1.36433145
36PASK1.35416129
37EIF2AK11.33422328
38CSNK1G11.33026847
39CSNK1G21.23719381
40NUAK11.23659382
41PBK1.21053750
42MINK11.19809066
43CSNK1A1L1.17999176
44PLK41.11700929
45EIF2AK31.08471645
46WEE11.02735831
47UHMK11.02428766
48TSSK60.98702604
49NEK20.96972283
50PKN10.93512815
51BRSK20.93192225
52LIMK10.91623408
53MAP3K100.91470394
54CHEK20.90650100
55PINK10.87975856
56NTRK30.87793198
57BCR0.84582539
58MKNK10.84149966
59WNK40.79371959
60DAPK10.79216010
61FRK0.78940447
62PHKG20.76201668
63PHKG10.76201668
64SIK20.75256448
65MAP3K110.70628469
66FGFR20.69520428
67RAF10.69202357
68RPS6KA50.67113591
69CDK30.66413799
70NTRK20.64990782
71AURKB0.64368666
72PRKCG0.63484055
73PLK20.63440245
74PAK60.63241542
75ATM0.63095872
76AURKA0.61217505
77ERBB40.60497227
78CAMKK20.59830559
79KDR0.55202987
80MAP3K50.49067877
81CDK180.47095191
82CDK140.46142076
83OXSR10.46141983
84CDK150.43869179
85CDK11A0.43019363
86CDK10.42907979
87CSNK2A10.42143979
88CSNK2A20.41867730
89CSNK1A10.41365886
90ALK0.40952160
91PRKDC0.40781503
92CAMK2A0.39473965
93CHEK10.37976350
94CDK20.37687893
95FGFR10.35102758
96CDK50.34775216
97PNCK0.33796877
98CAMKK10.32186531
99GRK10.30869838
100BRAF0.30869750

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.71183798
2DNA replication_Homo sapiens_hsa030302.71072732
3Mismatch repair_Homo sapiens_hsa034302.69720610
4Parkinsons disease_Homo sapiens_hsa050122.50402799
5RNA polymerase_Homo sapiens_hsa030202.45254489
6Homologous recombination_Homo sapiens_hsa034402.37121564
7Proteasome_Homo sapiens_hsa030502.30655710
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23483824
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21485892
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07377346
11Non-homologous end-joining_Homo sapiens_hsa034501.99654905
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98392403
13Base excision repair_Homo sapiens_hsa034101.97843748
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.96497912
15Biosynthesis of amino acids_Homo sapiens_hsa012301.92376626
16Ribosome_Homo sapiens_hsa030101.82631116
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78449893
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78156244
19Fanconi anemia pathway_Homo sapiens_hsa034601.77584274
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70541429
21Huntingtons disease_Homo sapiens_hsa050161.70491907
22Propanoate metabolism_Homo sapiens_hsa006401.60557089
23Steroid biosynthesis_Homo sapiens_hsa001001.60487840
24Pyruvate metabolism_Homo sapiens_hsa006201.59050850
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55046998
26Butanoate metabolism_Homo sapiens_hsa006501.54196226
27Carbon metabolism_Homo sapiens_hsa012001.50067712
28Nucleotide excision repair_Homo sapiens_hsa034201.49013629
29Fatty acid elongation_Homo sapiens_hsa000621.48429974
30Sulfur relay system_Homo sapiens_hsa041221.46896959
31One carbon pool by folate_Homo sapiens_hsa006701.45510238
32Alzheimers disease_Homo sapiens_hsa050101.45379980
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43179150
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39811640
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39135210
36Protein export_Homo sapiens_hsa030601.35905231
37RNA transport_Homo sapiens_hsa030131.33541568
38Pyrimidine metabolism_Homo sapiens_hsa002401.32631276
39Nicotine addiction_Homo sapiens_hsa050331.29868557
40Spliceosome_Homo sapiens_hsa030401.29076450
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27512478
42RNA degradation_Homo sapiens_hsa030181.26561488
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.25207207
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22086547
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.21688927
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14808993
47Cardiac muscle contraction_Homo sapiens_hsa042601.11906440
48Purine metabolism_Homo sapiens_hsa002301.11287391
49Phototransduction_Homo sapiens_hsa047441.09274241
50Peroxisome_Homo sapiens_hsa041461.06808705
51Fatty acid metabolism_Homo sapiens_hsa012121.04075173
52Vitamin B6 metabolism_Homo sapiens_hsa007501.00403492
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99178833
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96828843
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95501525
56Arginine biosynthesis_Homo sapiens_hsa002200.92935264
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91953848
58Cell cycle_Homo sapiens_hsa041100.87651955
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87632440
60Selenocompound metabolism_Homo sapiens_hsa004500.86065075
61Basal transcription factors_Homo sapiens_hsa030220.85931269
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.84982746
63Metabolic pathways_Homo sapiens_hsa011000.84814640
64Oocyte meiosis_Homo sapiens_hsa041140.79925896
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79142818
66GABAergic synapse_Homo sapiens_hsa047270.78509093
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77677411
68Phenylalanine metabolism_Homo sapiens_hsa003600.77110167
69Caffeine metabolism_Homo sapiens_hsa002320.74519007
70Synaptic vesicle cycle_Homo sapiens_hsa047210.71276941
71Fatty acid degradation_Homo sapiens_hsa000710.70243859
72Folate biosynthesis_Homo sapiens_hsa007900.68660510
73Pentose phosphate pathway_Homo sapiens_hsa000300.68578131
74Arginine and proline metabolism_Homo sapiens_hsa003300.67659101
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.65394640
76Alcoholism_Homo sapiens_hsa050340.63397423
77mRNA surveillance pathway_Homo sapiens_hsa030150.62160416
78Collecting duct acid secretion_Homo sapiens_hsa049660.57885655
79Lysine degradation_Homo sapiens_hsa003100.52985903
80Tyrosine metabolism_Homo sapiens_hsa003500.50294240
81Tryptophan metabolism_Homo sapiens_hsa003800.49525382
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.47491413
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43503789
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41928476
85beta-Alanine metabolism_Homo sapiens_hsa004100.41173962
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40945666
87Morphine addiction_Homo sapiens_hsa050320.40198025
88Retinol metabolism_Homo sapiens_hsa008300.39665206
89Regulation of autophagy_Homo sapiens_hsa041400.38942725
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38831918
91Galactose metabolism_Homo sapiens_hsa000520.37881886
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37667234
93Fructose and mannose metabolism_Homo sapiens_hsa000510.36609595
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36364839
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34556222
96Chemical carcinogenesis_Homo sapiens_hsa052040.33555646
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31571010
98Glutathione metabolism_Homo sapiens_hsa004800.31121116
99Glutamatergic synapse_Homo sapiens_hsa047240.29729548
100N-Glycan biosynthesis_Homo sapiens_hsa005100.28405593

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