KYAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid, which is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.08544780
2CENP-A containing nucleosome assembly (GO:0034080)5.04739581
3proteasome assembly (GO:0043248)4.80839429
4DNA double-strand break processing (GO:0000729)4.42968140
5regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.40777531
6regulation of mitotic spindle checkpoint (GO:1903504)4.40777531
7regulation of helicase activity (GO:0051095)4.39877154
8histone exchange (GO:0043486)4.36396148
9cullin deneddylation (GO:0010388)4.20168789
10purine nucleobase biosynthetic process (GO:0009113)4.07231430
11protein neddylation (GO:0045116)3.94162580
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92592712
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89481263
14IMP biosynthetic process (GO:0006188)3.87319173
15DNA replication-independent nucleosome organization (GO:0034724)3.82739254
16DNA replication-independent nucleosome assembly (GO:0006336)3.82739254
17protein deneddylation (GO:0000338)3.76178069
18negative regulation of DNA-dependent DNA replication (GO:2000104)3.76071653
19negative regulation of mitotic sister chromatid segregation (GO:0033048)3.73766862
20negative regulation of mitotic sister chromatid separation (GO:2000816)3.73766862
21negative regulation of sister chromatid segregation (GO:0033046)3.73766862
22negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.73766862
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.73766862
24DNA catabolic process, exonucleolytic (GO:0000738)3.70626305
25IMP metabolic process (GO:0046040)3.66514427
26establishment of integrated proviral latency (GO:0075713)3.63425091
27negative regulation of chromosome segregation (GO:0051985)3.62865107
28ribosome assembly (GO:0042255)3.61121701
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.61038756
30negative regulation of ligase activity (GO:0051352)3.60086251
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.60086251
32nucleobase biosynthetic process (GO:0046112)3.59625214
33DNA replication checkpoint (GO:0000076)3.57684496
34mitotic spindle checkpoint (GO:0071174)3.55268349
35regulation of meiosis I (GO:0060631)3.54612014
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52579952
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52579952
38branched-chain amino acid catabolic process (GO:0009083)3.52522995
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51977383
40regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50667904
41regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50667904
42spindle checkpoint (GO:0031577)3.46944645
43mitotic spindle assembly checkpoint (GO:0007094)3.42564772
44respiratory chain complex IV assembly (GO:0008535)3.39387008
45spindle assembly checkpoint (GO:0071173)3.39269863
46DNA ligation (GO:0006266)3.38822688
47non-recombinational repair (GO:0000726)3.38120750
48double-strand break repair via nonhomologous end joining (GO:0006303)3.38120750
49regulation of mitotic sister chromatid separation (GO:0010965)3.36377172
50regulation of mitotic sister chromatid segregation (GO:0033047)3.36377172
51regulation of sister chromatid segregation (GO:0033045)3.36377172
52L-serine metabolic process (GO:0006563)3.30833436
53mitotic G2/M transition checkpoint (GO:0044818)3.30552713
54histone mRNA metabolic process (GO:0008334)3.30480185
55regulation of mitochondrial translation (GO:0070129)3.28754362
56folic acid-containing compound biosynthetic process (GO:0009396)3.26865633
57mitotic metaphase plate congression (GO:0007080)3.26491211
58pteridine-containing compound biosynthetic process (GO:0042559)3.24701901
59negative regulation of DNA recombination (GO:0045910)3.19756803
60nuclear pore complex assembly (GO:0051292)3.15700332
61regulation of chromosome segregation (GO:0051983)3.15150053
62metaphase plate congression (GO:0051310)3.11895166
63somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09667961
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.09667961
65response to X-ray (GO:0010165)3.08386249
66mitotic recombination (GO:0006312)3.07942026
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06499086
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06499086
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06499086
70somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.06063721
71somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.06063721
72isotype switching (GO:0045190)3.06063721
73protein localization to kinetochore (GO:0034501)3.05872867
74maturation of 5.8S rRNA (GO:0000460)3.01748571
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00769332
76mismatch repair (GO:0006298)2.99223606
77intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99121185
78signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99121185
79regulation of cellular amino acid metabolic process (GO:0006521)2.99011791
80nuclear pore organization (GO:0006999)2.98372458
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97894196
82negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.95140787
83negative regulation of mitosis (GO:0045839)2.94981552
84oxidative phosphorylation (GO:0006119)2.93415867
85signal transduction involved in DNA damage checkpoint (GO:0072422)2.92521573
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.92521573
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.92498977
88telomere maintenance via semi-conservative replication (GO:0032201)2.91909024
89positive regulation of ligase activity (GO:0051351)2.91373085
90establishment of protein localization to mitochondrial membrane (GO:0090151)2.90806651
91establishment of viral latency (GO:0019043)2.90412746
92synapsis (GO:0007129)2.89464112
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.89316338
94RNA-dependent DNA replication (GO:0006278)2.87932016
95regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.87694467
96mitotic sister chromatid cohesion (GO:0007064)2.86987676
97lactate metabolic process (GO:0006089)2.86886648
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.85998508
99DNA damage response, detection of DNA damage (GO:0042769)2.85288022
100regulation of ligase activity (GO:0051340)2.84171181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26280233
2E2F7_22180533_ChIP-Seq_HELA_Human4.00148666
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.71451842
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53407107
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15190744
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.11192491
7ELK1_19687146_ChIP-ChIP_HELA_Human3.08480915
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84525034
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.67084995
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.65096672
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43451423
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31264226
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.26727728
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23007801
15VDR_23849224_ChIP-Seq_CD4+_Human2.20184232
16FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.17343422
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15377149
18PADI4_21655091_ChIP-ChIP_MCF-7_Human2.09375656
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.08602442
20AR_21909140_ChIP-Seq_LNCAP_Human2.02005679
21FOXP3_21729870_ChIP-Seq_TREG_Human2.01868061
22EWS_26573619_Chip-Seq_HEK293_Human2.00819031
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99134625
24FUS_26573619_Chip-Seq_HEK293_Human1.98483452
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98387289
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.97130507
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92735067
28IGF1R_20145208_ChIP-Seq_DFB_Human1.90475536
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87869177
30HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81891624
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74888851
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74315016
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70331033
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67939709
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.58624893
36TAF15_26573619_Chip-Seq_HEK293_Human1.57955979
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.56306359
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56271846
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54996884
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54749565
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53843616
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.49310096
43DCP1A_22483619_ChIP-Seq_HELA_Human1.45864925
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45657861
45MYC_18940864_ChIP-ChIP_HL60_Human1.45225968
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.42317748
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40130923
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39160881
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38302076
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37894447
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35495356
52ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32823272
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.30572469
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30264514
55P300_19829295_ChIP-Seq_ESCs_Human1.26944813
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26393033
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25968544
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25866755
59TTF2_22483619_ChIP-Seq_HELA_Human1.23142970
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21893174
61GABP_19822575_ChIP-Seq_HepG2_Human1.21832862
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19625811
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18859498
64ZNF274_21170338_ChIP-Seq_K562_Hela1.18121507
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18102721
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17868635
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.15696590
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15274490
69VDR_22108803_ChIP-Seq_LS180_Human1.10856133
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10685913
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07886677
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07486017
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06954467
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05212569
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05053139
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04816519
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04340761
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.04294738
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03906795
80GATA1_22025678_ChIP-Seq_K562_Human1.03868838
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99295121
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99184117
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.98099031
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97913960
85THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95708726
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95266212
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94450675
88IRF1_19129219_ChIP-ChIP_H3396_Human0.93501290
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.92530943
90CRX_20693478_ChIP-Seq_RETINA_Mouse0.92250485
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89111159
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88522440
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88062972
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88054481
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86519606
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86126820
97NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85253991
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83726085
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82915393
100NANOG_19829295_ChIP-Seq_ESCs_Human0.82053264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage4.36022186
2MP0008058_abnormal_DNA_repair3.77000881
3MP0010094_abnormal_chromosome_stability3.58389413
4MP0004957_abnormal_blastocyst_morpholog3.39517946
5MP0009697_abnormal_copulation3.33914325
6MP0003890_abnormal_embryonic-extraembry3.30523222
7MP0003941_abnormal_skin_development3.17320889
8MP0008057_abnormal_DNA_replication3.09884275
9MP0003693_abnormal_embryo_hatching2.91553263
10MP0003111_abnormal_nucleus_morphology2.68252753
11MP0008877_abnormal_DNA_methylation2.56596745
12MP0002254_reproductive_system_inflammat2.49011371
13MP0006292_abnormal_olfactory_placode2.47605758
14MP0003077_abnormal_cell_cycle2.46386396
15MP0008932_abnormal_embryonic_tissue2.39901617
16MP0005075_abnormal_melanosome_morpholog2.24579684
17MP0010352_gastrointestinal_tract_polyps2.18425898
18MP0008007_abnormal_cellular_replicative2.17346959
19MP0006072_abnormal_retinal_apoptosis2.15813890
20MP0002938_white_spotting2.09386684
21MP0003567_abnormal_fetal_cardiomyocyte2.02547752
22MP0003786_premature_aging2.01957298
23MP0001293_anophthalmia2.01350034
24MP0002102_abnormal_ear_morphology1.87744871
25MP0003121_genomic_imprinting1.85047692
26MP0002138_abnormal_hepatobiliary_system1.84390329
27MP0004147_increased_porphyrin_level1.83313294
28MP0003806_abnormal_nucleotide_metabolis1.82564400
29MP0003186_abnormal_redox_activity1.82311009
30MP0005367_renal/urinary_system_phenotyp1.80012995
31MP0000516_abnormal_urinary_system1.80012995
32MP0006035_abnormal_mitochondrial_morpho1.74390660
33MP0005379_endocrine/exocrine_gland_phen1.61448448
34MP0003195_calcinosis1.52845700
35MP0003718_maternal_effect1.51786618
36MP0003011_delayed_dark_adaptation1.48904174
37MP0001730_embryonic_growth_arrest1.41436312
38MP0000569_abnormal_digit_pigmentation1.37381378
39MP0002163_abnormal_gland_morphology1.35873912
40MP0000358_abnormal_cell_content/1.30972701
41MP0010307_abnormal_tumor_latency1.30456000
42MP0001661_extended_life_span1.27964085
43MP0005253_abnormal_eye_physiology1.27439163
44MP0000372_irregular_coat_pigmentation1.26737552
45MP0003937_abnormal_limbs/digits/tail_de1.26557746
46MP0005084_abnormal_gallbladder_morpholo1.23120856
47MP0002084_abnormal_developmental_patter1.22871140
48MP0005220_abnormal_exocrine_pancreas1.22338388
49MP0005380_embryogenesis_phenotype1.21260487
50MP0001672_abnormal_embryogenesis/_devel1.21260487
51MP0000647_abnormal_sebaceous_gland1.20875713
52MP0006036_abnormal_mitochondrial_physio1.20426513
53MP0003787_abnormal_imprinting1.20043849
54MP0001697_abnormal_embryo_size1.19421349
55MP0005408_hypopigmentation1.11452686
56MP0000350_abnormal_cell_proliferation1.08971744
57MP0002837_dystrophic_cardiac_calcinosis1.07830190
58MP0008789_abnormal_olfactory_epithelium1.07706318
59MP0001324_abnormal_eye_pigmentation1.06467773
60MP0001529_abnormal_vocalization1.06355014
61MP0004133_heterotaxia1.04921332
62MP0009672_abnormal_birth_weight1.04862087
63MP0003984_embryonic_growth_retardation0.96049988
64MP0002088_abnormal_embryonic_growth/wei0.94300562
65MP0002085_abnormal_embryonic_tissue0.92965877
66MP0005332_abnormal_amino_acid0.92555150
67MP0002090_abnormal_vision0.92242001
68MP0001286_abnormal_eye_development0.92090521
69MP0001119_abnormal_female_reproductive0.91928149
70MP0001764_abnormal_homeostasis0.84405698
71MP0002751_abnormal_autonomic_nervous0.84081788
72MP0003221_abnormal_cardiomyocyte_apopto0.83263120
73MP0009703_decreased_birth_body0.82987063
74MP0003123_paternal_imprinting0.81164361
75MP0005248_abnormal_Harderian_gland0.80534045
76MP0005391_vision/eye_phenotype0.80147215
77MP0001177_atelectasis0.79366088
78MP0000653_abnormal_sex_gland0.79250481
79MP0002080_prenatal_lethality0.76705438
80MP0001929_abnormal_gametogenesis0.76530432
81MP0000313_abnormal_cell_death0.76344917
82MP0002697_abnormal_eye_size0.70039517
83MP0002233_abnormal_nose_morphology0.69803947
84MP0002095_abnormal_skin_pigmentation0.68911971
85MP0005395_other_phenotype0.68766375
86MP0001145_abnormal_male_reproductive0.68613053
87MP0003136_yellow_coat_color0.67869659
88MP0001853_heart_inflammation0.66116064
89MP0002210_abnormal_sex_determination0.65905479
90MP0003300_gastrointestinal_ulcer0.65405874
91MP0003122_maternal_imprinting0.64353729
92MP0001984_abnormal_olfaction0.64222780
93MP0002796_impaired_skin_barrier0.64028127
94MP0001915_intracranial_hemorrhage0.63717014
95MP0002086_abnormal_extraembryonic_tissu0.63010252
96MP0002277_abnormal_respiratory_mucosa0.60791564
97MP0004215_abnormal_myocardial_fiber0.58836254
98MP0002019_abnormal_tumor_incidence0.57618478
99MP0005394_taste/olfaction_phenotype0.57334920
100MP0005499_abnormal_olfactory_system0.57334920

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.72240784
2Abnormality of the labia minora (HP:0012880)3.30199386
3Abnormality of chromosome stability (HP:0003220)3.25259131
4Acute necrotizing encephalopathy (HP:0006965)3.12632696
5Abnormality of methionine metabolism (HP:0010901)3.12350698
6Rhabdomyosarcoma (HP:0002859)3.01644873
7Acute encephalopathy (HP:0006846)2.95295364
8Volvulus (HP:0002580)2.94240572
9Chromsome breakage (HP:0040012)2.92840374
10Methylmalonic acidemia (HP:0002912)2.92526724
11Medulloblastoma (HP:0002885)2.90035986
12Meckel diverticulum (HP:0002245)2.85913231
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84031906
14Increased hepatocellular lipid droplets (HP:0006565)2.79085842
15Abnormality of serum amino acid levels (HP:0003112)2.78384467
16Progressive macrocephaly (HP:0004481)2.73565435
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.68578898
18Abnormality of aspartate family amino acid metabolism (HP:0010899)2.67031355
19Abnormality of the ileum (HP:0001549)2.65984371
20Abnormal lung lobation (HP:0002101)2.65570704
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.64975449
22Abnormality of alanine metabolism (HP:0010916)2.64975449
23Hyperalaninemia (HP:0003348)2.64975449
24Type I transferrin isoform profile (HP:0003642)2.63911583
25Increased CSF lactate (HP:0002490)2.61599751
26Biliary tract neoplasm (HP:0100574)2.59201770
27Reduced antithrombin III activity (HP:0001976)2.57145931
28Hyperglycinemia (HP:0002154)2.56662965
29Intestinal atresia (HP:0011100)2.55979579
30Agnosia (HP:0010524)2.55710577
31Abnormal mitochondria in muscle tissue (HP:0008316)2.53503766
32Abnormality of glycine metabolism (HP:0010895)2.52906500
33Abnormality of serine family amino acid metabolism (HP:0010894)2.52906500
34Increased serum pyruvate (HP:0003542)2.51265249
35Abnormality of the duodenum (HP:0002246)2.49844123
36Abnormal glycosylation (HP:0012345)2.47729523
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47729523
38Abnormal protein N-linked glycosylation (HP:0012347)2.47729523
39Abnormal protein glycosylation (HP:0012346)2.47729523
40Lipid accumulation in hepatocytes (HP:0006561)2.46316002
41Cerebral edema (HP:0002181)2.43649116
42Abnormality of the preputium (HP:0100587)2.40522000
43Small intestinal stenosis (HP:0012848)2.38586696
44Duodenal stenosis (HP:0100867)2.38586696
45Mitochondrial inheritance (HP:0001427)2.38244020
46Ovarian neoplasm (HP:0100615)2.32062759
47Aplastic anemia (HP:0001915)2.31055934
48Hyperinsulinemic hypoglycemia (HP:0000825)2.25135249
49Hyperglycinuria (HP:0003108)2.24313548
50Neoplasm of the colon (HP:0100273)2.23283067
51Stenosis of the external auditory canal (HP:0000402)2.23268153
52Methylmalonic aciduria (HP:0012120)2.21822456
53Pancreatic islet-cell hyperplasia (HP:0004510)2.20575088
54Intrahepatic cholestasis (HP:0001406)2.18707369
55Neoplasm of the adrenal gland (HP:0100631)2.17856369
56IgM deficiency (HP:0002850)2.17457503
57Abnormality of vitamin B metabolism (HP:0004340)2.16294452
58Nephroblastoma (Wilms tumor) (HP:0002667)2.15388639
59Embryonal renal neoplasm (HP:0011794)2.14947681
60Hypoglycemic seizures (HP:0002173)2.13176721
61Median cleft lip (HP:0000161)2.13106311
62Abnormality of glycolysis (HP:0004366)2.07480674
63Gonadotropin excess (HP:0000837)2.07425322
64Pancreatic fibrosis (HP:0100732)2.06334525
65Degeneration of anterior horn cells (HP:0002398)2.02560313
66Abnormality of the anterior horn cell (HP:0006802)2.02560313
67True hermaphroditism (HP:0010459)2.00992362
68Supernumerary spleens (HP:0009799)2.00718394
69Postnatal microcephaly (HP:0005484)2.00668267
70Sloping forehead (HP:0000340)1.99032495
71Breast carcinoma (HP:0003002)1.97435700
72Abnormality of the fovea (HP:0000493)1.96373519
73Abnormality of the vitamin B12 metabolism (HP:0004341)1.94763036
74Neoplasm of the small intestine (HP:0100833)1.94730392
75Lethargy (HP:0001254)1.94510744
76Symptomatic seizures (HP:0011145)1.94455966
77Pancreatic cysts (HP:0001737)1.94075202
78Hepatocellular necrosis (HP:0001404)1.91783511
79Aplasia/Hypoplasia of the fovea (HP:0008060)1.90404284
80Hypoplasia of the fovea (HP:0007750)1.90404284
81Medial flaring of the eyebrow (HP:0010747)1.90146241
82Clubbing of toes (HP:0100760)1.88760247
83Single umbilical artery (HP:0001195)1.87010828
84Abnormality of the fetal cardiovascular system (HP:0010948)1.87010828
85Abnormal umbilical cord blood vessels (HP:0011403)1.87010828
86Poor head control (HP:0002421)1.85325706
87Congenital, generalized hypertrichosis (HP:0004540)1.83580662
88Abnormal biliary tract morphology (HP:0012440)1.81583623
89Megaloblastic anemia (HP:0001889)1.80821762
90Uterine neoplasm (HP:0010784)1.78672517
91Increased serum lactate (HP:0002151)1.76853745
92Lactic acidosis (HP:0003128)1.75207419
93Neoplasm of striated muscle (HP:0009728)1.74676703
94Postaxial foot polydactyly (HP:0001830)1.74234918
95Bifid tongue (HP:0010297)1.73018245
96Ependymoma (HP:0002888)1.72061466
97Triphalangeal thumb (HP:0001199)1.71455228
98Multiple enchondromatosis (HP:0005701)1.69264352
99Genital tract atresia (HP:0001827)1.69065594
100Renal Fanconi syndrome (HP:0001994)1.68588340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.54331244
2PBK3.26155453
3MST43.15576027
4TRIM282.91561638
5TTK2.84218882
6MKNK12.81352808
7ZAK2.78789681
8EIF2AK32.73653241
9SRPK12.54303070
10MKNK22.41107906
11PLK32.40357710
12PLK42.37344833
13BCR2.37052457
14NUAK12.15439987
15NEK12.10638952
16TSSK62.03931219
17CDC72.02480335
18EIF2AK11.90120262
19TNIK1.83034526
20WEE11.81890833
21ERBB31.77443320
22ACVR1B1.75463708
23WNK31.73533371
24BMPR1B1.70470539
25CDK191.68166230
26STK31.50257511
27MAP4K21.49873987
28VRK21.47732800
29BRSK21.43010442
30LATS11.40010116
31PLK11.36063925
32TAF11.32419614
33VRK11.30727396
34GRK11.26845531
35CSNK1G11.17266872
36EIF2AK21.13684018
37PLK21.13150333
38STK38L1.11863206
39PASK1.11486642
40PDK21.08463372
41NLK1.07111136
42SIK31.06664746
43OXSR10.97939440
44MAP3K120.93988312
45STK160.93549825
46CSNK1G30.91651765
47FRK0.90490577
48CHEK20.90390008
49STK100.89638132
50STK40.83420614
51PAK40.82101887
52STK390.75588142
53ATR0.74931042
54CSNK1G20.73633489
55NEK90.73493230
56RPS6KA40.73214440
57FGFR10.71653367
58CDK60.68394873
59ATM0.68177954
60TGFBR10.67409212
61ALK0.65541344
62AURKB0.63460097
63CSNK1A1L0.62011856
64IRAK20.60758197
65DYRK30.60714365
66STK240.58690096
67BRSK10.57904488
68ADRBK20.57864772
69BMPR20.55125693
70YES10.54477949
71TXK0.54146181
72BCKDK0.53885695
73DYRK20.53753058
74NME10.52111766
75PINK10.50259224
76CHEK10.48104635
77CSNK2A10.47539222
78IRAK10.47154288
79CDK30.44118954
80NEK20.43033155
81CSNK2A20.42601878
82MAP3K80.41725913
83FER0.40903616
84MAP3K40.40647800
85PRKCE0.40263995
86NME20.38599208
87BRD40.37606845
88FGFR20.36277599
89TEC0.35957178
90TGFBR20.35519836
91SCYL20.32180895
92CDK70.28511832
93PAK30.27763068
94ERBB40.26754694
95EGFR0.25130506
96CLK10.23956948
97PRKDC0.23506440
98DAPK10.22128438
99CSNK1A10.21675300
100CSNK1E0.21554407

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.11709475
2Protein export_Homo sapiens_hsa030603.74036185
3Mismatch repair_Homo sapiens_hsa034303.38934849
4Non-homologous end-joining_Homo sapiens_hsa034503.20814639
5Propanoate metabolism_Homo sapiens_hsa006402.66084976
6Homologous recombination_Homo sapiens_hsa034402.54378769
7DNA replication_Homo sapiens_hsa030302.49123252
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25481236
9RNA transport_Homo sapiens_hsa030132.05339872
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04219546
11Fanconi anemia pathway_Homo sapiens_hsa034602.03838087
12One carbon pool by folate_Homo sapiens_hsa006702.01333765
13Basal transcription factors_Homo sapiens_hsa030221.99636001
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98769805
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93585425
16Oxidative phosphorylation_Homo sapiens_hsa001901.93466745
17Nucleotide excision repair_Homo sapiens_hsa034201.91811335
18Steroid biosynthesis_Homo sapiens_hsa001001.88380749
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86472506
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85510022
21RNA polymerase_Homo sapiens_hsa030201.84389704
22Fatty acid elongation_Homo sapiens_hsa000621.84340874
23Sulfur metabolism_Homo sapiens_hsa009201.78317797
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.68095410
25Vitamin B6 metabolism_Homo sapiens_hsa007501.67245555
26Spliceosome_Homo sapiens_hsa030401.65882716
27Pyruvate metabolism_Homo sapiens_hsa006201.65295348
28RNA degradation_Homo sapiens_hsa030181.65270644
29Cell cycle_Homo sapiens_hsa041101.63645891
30Parkinsons disease_Homo sapiens_hsa050121.60721807
31Base excision repair_Homo sapiens_hsa034101.60582726
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59977476
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48081402
34Folate biosynthesis_Homo sapiens_hsa007901.42512202
35Selenocompound metabolism_Homo sapiens_hsa004501.39980478
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35071557
37Ribosome_Homo sapiens_hsa030101.27737754
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27049511
39Glutathione metabolism_Homo sapiens_hsa004801.18944017
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18574236
41Pyrimidine metabolism_Homo sapiens_hsa002401.16193012
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15366669
43Huntingtons disease_Homo sapiens_hsa050161.06496211
44Purine metabolism_Homo sapiens_hsa002301.04885402
45Carbon metabolism_Homo sapiens_hsa012001.00321269
46mRNA surveillance pathway_Homo sapiens_hsa030150.95904897
47Butanoate metabolism_Homo sapiens_hsa006500.92041032
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91750914
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86225755
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85281507
51N-Glycan biosynthesis_Homo sapiens_hsa005100.79013933
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78228169
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77595620
54Alzheimers disease_Homo sapiens_hsa050100.76500433
55Oocyte meiosis_Homo sapiens_hsa041140.75843775
56Fatty acid metabolism_Homo sapiens_hsa012120.75280336
57Fatty acid degradation_Homo sapiens_hsa000710.75142972
58p53 signaling pathway_Homo sapiens_hsa041150.73601965
59Metabolic pathways_Homo sapiens_hsa011000.72943482
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71603176
61Peroxisome_Homo sapiens_hsa041460.70676152
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70501863
63Caffeine metabolism_Homo sapiens_hsa002320.70291385
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69810127
65Biosynthesis of amino acids_Homo sapiens_hsa012300.69611182
66beta-Alanine metabolism_Homo sapiens_hsa004100.67293122
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61996124
68Phototransduction_Homo sapiens_hsa047440.60890146
69Retinol metabolism_Homo sapiens_hsa008300.56013976
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.54507945
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.52263607
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51324196
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49839089
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49760716
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47472247
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.47019884
77Chemical carcinogenesis_Homo sapiens_hsa052040.47007497
78Ether lipid metabolism_Homo sapiens_hsa005650.44253614
79TGF-beta signaling pathway_Homo sapiens_hsa043500.44235871
80Regulation of autophagy_Homo sapiens_hsa041400.43734132
81Type I diabetes mellitus_Homo sapiens_hsa049400.42527383
82Tryptophan metabolism_Homo sapiens_hsa003800.37964235
83Collecting duct acid secretion_Homo sapiens_hsa049660.37870585
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36454224
85Vitamin digestion and absorption_Homo sapiens_hsa049770.36141735
86Epstein-Barr virus infection_Homo sapiens_hsa051690.32942414
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32895044
88Arginine and proline metabolism_Homo sapiens_hsa003300.30238669
89Asthma_Homo sapiens_hsa053100.27506339
90Wnt signaling pathway_Homo sapiens_hsa043100.26806096
91Legionellosis_Homo sapiens_hsa051340.25878596
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.25009777
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24283759
94Nitrogen metabolism_Homo sapiens_hsa009100.24176072
95Basal cell carcinoma_Homo sapiens_hsa052170.23684764
96Hedgehog signaling pathway_Homo sapiens_hsa043400.18837353
97Arachidonic acid metabolism_Homo sapiens_hsa005900.17392515
98Herpes simplex infection_Homo sapiens_hsa051680.16112458
99Starch and sucrose metabolism_Homo sapiens_hsa005000.15984565
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15316691

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