KYNU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.46903116
2L-phenylalanine catabolic process (GO:0006559)7.46903116
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.06705673
4L-phenylalanine metabolic process (GO:0006558)7.06705673
5* aromatic amino acid family catabolic process (GO:0009074)6.89148294
6* indole-containing compound catabolic process (GO:0042436)6.33149000
7* indolalkylamine catabolic process (GO:0046218)6.33149000
8* tryptophan catabolic process (GO:0006569)6.33149000
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.07372505
10* kynurenine metabolic process (GO:0070189)6.01559907
11bile acid biosynthetic process (GO:0006699)6.00729407
12* tryptophan metabolic process (GO:0006568)5.90722731
13urea metabolic process (GO:0019627)5.71420889
14urea cycle (GO:0000050)5.71420889
15glyoxylate metabolic process (GO:0046487)5.66744300
16complement activation, alternative pathway (GO:0006957)5.51897300
17high-density lipoprotein particle remodeling (GO:0034375)5.40903370
18alpha-linolenic acid metabolic process (GO:0036109)5.39197692
19negative regulation of fibrinolysis (GO:0051918)5.38679931
20regulation of protein activation cascade (GO:2000257)5.35929574
21regulation of fibrinolysis (GO:0051917)5.33387824
22peptidyl-glutamic acid carboxylation (GO:0017187)5.32733356
23protein carboxylation (GO:0018214)5.32733356
24nitrogen cycle metabolic process (GO:0071941)5.25053814
25cysteine metabolic process (GO:0006534)5.17629704
26sulfur amino acid catabolic process (GO:0000098)5.11713515
27bile acid metabolic process (GO:0008206)5.02892926
28regulation of complement activation (GO:0030449)5.02437610
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.93589633
30serine family amino acid catabolic process (GO:0009071)4.93321381
31cellular response to ethanol (GO:0071361)4.91677543
32* aromatic amino acid family metabolic process (GO:0009072)4.88060453
33homocysteine metabolic process (GO:0050667)4.84492864
34regulation of cholesterol esterification (GO:0010872)4.79436037
35tyrosine metabolic process (GO:0006570)4.74393324
36reverse cholesterol transport (GO:0043691)4.72994444
37regulation of triglyceride catabolic process (GO:0010896)4.68180115
38plasma lipoprotein particle remodeling (GO:0034369)4.68068211
39protein-lipid complex remodeling (GO:0034368)4.68068211
40macromolecular complex remodeling (GO:0034367)4.68068211
41phospholipid efflux (GO:0033700)4.56364429
42* alpha-amino acid catabolic process (GO:1901606)4.49774610
43triglyceride homeostasis (GO:0070328)4.46115871
44acylglycerol homeostasis (GO:0055090)4.46115871
45amino-acid betaine metabolic process (GO:0006577)4.44059719
46negative regulation of sterol transport (GO:0032372)4.41453987
47negative regulation of cholesterol transport (GO:0032375)4.41453987
48coenzyme catabolic process (GO:0009109)4.36799087
49imidazole-containing compound metabolic process (GO:0052803)4.36154678
50* indolalkylamine metabolic process (GO:0006586)4.36021473
51bile acid and bile salt transport (GO:0015721)4.35108810
52lysine catabolic process (GO:0006554)4.34033687
53lysine metabolic process (GO:0006553)4.34033687
54plasma lipoprotein particle clearance (GO:0034381)4.31380646
55* cellular biogenic amine catabolic process (GO:0042402)4.30560302
56* amine catabolic process (GO:0009310)4.30560302
57aldehyde catabolic process (GO:0046185)4.21845085
58cellular glucuronidation (GO:0052695)4.20137475
59cholesterol efflux (GO:0033344)4.16584248
60glycine metabolic process (GO:0006544)4.14781826
61cellular ketone body metabolic process (GO:0046950)4.14692757
62low-density lipoprotein particle remodeling (GO:0034374)4.11727627
63* cellular amino acid catabolic process (GO:0009063)4.09513776
64positive regulation of heat generation (GO:0031652)4.09422148
65glutamate metabolic process (GO:0006536)4.04763226
66ethanol oxidation (GO:0006069)4.04016594
67fibrinolysis (GO:0042730)4.01833891
68arginine metabolic process (GO:0006525)3.98310272
69serine family amino acid metabolic process (GO:0009069)3.96075850
70* benzene-containing compound metabolic process (GO:0042537)3.94833944
71blood coagulation, intrinsic pathway (GO:0007597)3.91395896
72glucuronate metabolic process (GO:0019585)3.85521224
73uronic acid metabolic process (GO:0006063)3.85521224
74complement activation, classical pathway (GO:0006958)3.84573533
75plasma lipoprotein particle assembly (GO:0034377)3.82731319
76signal peptide processing (GO:0006465)3.82486713
77cofactor catabolic process (GO:0051187)3.82441082
78protein activation cascade (GO:0072376)3.81714992
79phospholipid homeostasis (GO:0055091)3.79935476
80complement activation (GO:0006956)3.79760845
81cytolysis (GO:0019835)3.78448303
82serine family amino acid biosynthetic process (GO:0009070)3.74955790
83regulation of establishment of cell polarity (GO:2000114)3.71436809
84negative regulation of interleukin-12 production (GO:0032695)3.69196521
85very-low-density lipoprotein particle assembly (GO:0034379)3.66613223
86positive regulation of lipid catabolic process (GO:0050996)3.66030847
87* NAD biosynthetic process (GO:0009435)3.66007977
88positive regulation of triglyceride lipase activity (GO:0061365)3.65046221
89positive regulation of lipoprotein lipase activity (GO:0051006)3.65046221
90drug catabolic process (GO:0042737)3.64829594
91* cellular modified amino acid catabolic process (GO:0042219)3.63754962
92* dicarboxylic acid biosynthetic process (GO:0043650)3.61812079
93opsonization (GO:0008228)3.60747131
94cholesterol homeostasis (GO:0042632)3.59993757
95acute-phase response (GO:0006953)3.59656044
96negative regulation of lipase activity (GO:0060192)3.58104795
97ketone body metabolic process (GO:1902224)3.57463818
98* organic acid catabolic process (GO:0016054)3.57330896
99* carboxylic acid catabolic process (GO:0046395)3.57330896
100regulation of bile acid biosynthetic process (GO:0070857)3.56825798
101plasma lipoprotein particle organization (GO:0071827)3.55970724
102* nicotinamide nucleotide biosynthetic process (GO:0019359)3.55398180
103* pyridine nucleotide biosynthetic process (GO:0019363)3.55398180
104sterol homeostasis (GO:0055092)3.53944631
105regulation of interleukin-12 biosynthetic process (GO:0045075)3.51040748
106regulation of vitamin D biosynthetic process (GO:0060556)3.48089968
107short-chain fatty acid metabolic process (GO:0046459)3.47755436
108sphingoid metabolic process (GO:0046519)3.28417655
109positive regulation of developmental pigmentation (GO:0048087)3.26567253
110lipid translocation (GO:0034204)3.25894324
111phospholipid translocation (GO:0045332)3.25894324
112regulation of heat generation (GO:0031650)3.23143028
113snRNA transcription (GO:0009301)3.22543744
114positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.21917923
115negative regulation of systemic arterial blood pressure (GO:0003085)3.21764412
116regulation of establishment or maintenance of cell polarity (GO:0032878)3.16607158
117monoubiquitinated protein deubiquitination (GO:0035520)3.12019416
118regulation of MHC class I biosynthetic process (GO:0045343)3.10007855
119protein K48-linked deubiquitination (GO:0071108)3.07784109
120regulation of memory T cell differentiation (GO:0043380)3.06656517
121negative regulation of mast cell activation (GO:0033004)3.03193883
122iron ion import (GO:0097286)2.99311312
123positive regulation of defense response to virus by host (GO:0002230)2.98253450
124regulation of interferon-alpha production (GO:0032647)2.98187216
125cellular response to ATP (GO:0071318)2.97268615
126response to peptidoglycan (GO:0032494)2.96420910
127T-helper 1 type immune response (GO:0042088)2.93958954
128superoxide anion generation (GO:0042554)2.90314190
129cellular response to exogenous dsRNA (GO:0071360)2.87079347
130regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.87046029
131flavonoid metabolic process (GO:0009812)2.85992724
132regulation of T-helper 1 cell differentiation (GO:0045625)2.84304505
133striated muscle atrophy (GO:0014891)2.82532251
134regulation of pigment cell differentiation (GO:0050932)2.82398619
135macrophage activation involved in immune response (GO:0002281)2.81566170
136response to type I interferon (GO:0034340)2.81486921
137regulation of hippo signaling (GO:0035330)2.81137074
138endosome to melanosome transport (GO:0035646)2.80771973
139endosome to pigment granule transport (GO:0043485)2.80771973
140detection of molecule of bacterial origin (GO:0032490)2.79692899
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79294097
142regulation of B cell receptor signaling pathway (GO:0050855)2.77938612
143regulation of vitamin metabolic process (GO:0030656)2.77130292
144protein K63-linked deubiquitination (GO:0070536)2.74617496
145hydrogen peroxide biosynthetic process (GO:0050665)2.73925778
146type I interferon signaling pathway (GO:0060337)2.70967353
147cellular response to type I interferon (GO:0071357)2.70967353
148regulation of fever generation (GO:0031620)2.70238169
149regulation of interleukin-12 production (GO:0032655)2.70176084
150positive regulation of interleukin-12 production (GO:0032735)2.69767734
151positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69176910
152regulation of chronic inflammatory response (GO:0002676)2.68241088
153UDP-N-acetylglucosamine metabolic process (GO:0006047)2.68205453
154cytokine biosynthetic process (GO:0042089)2.66860737
155detection of light stimulus involved in sensory perception (GO:0050962)2.65194748
156detection of light stimulus involved in visual perception (GO:0050908)2.65194748
157interferon-gamma-mediated signaling pathway (GO:0060333)2.65169844
158positive regulation of interferon-alpha production (GO:0032727)2.63630078
159cilium or flagellum-dependent cell motility (GO:0001539)2.63440129
160positive regulation of cAMP-mediated signaling (GO:0043950)2.63309163
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63136548
162positive regulation of gamma-delta T cell activation (GO:0046645)2.62425461
163establishment of protein localization to vacuole (GO:0072666)2.62178434
164protein targeting to vacuole (GO:0006623)2.62178434
165protein targeting to lysosome (GO:0006622)2.62178434
166positive regulation of natural killer cell activation (GO:0032816)2.60808003
167regulation of mononuclear cell migration (GO:0071675)2.59685266
168regulation of MHC class II biosynthetic process (GO:0045346)2.58504887
169positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.56226198
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55558955
171positive regulation of type 2 immune response (GO:0002830)2.54968806
172negative regulation of lipid storage (GO:0010888)2.51898670
173cellular extravasation (GO:0045123)2.47683228
174production of molecular mediator involved in inflammatory response (GO:0002532)2.47083388
175positive regulation of NF-kappaB import into nucleus (GO:0042346)2.44145703
176protein K11-linked deubiquitination (GO:0035871)2.43803257
177positive regulation of T-helper 1 type immune response (GO:0002827)2.43730085
178intracellular pH reduction (GO:0051452)2.43680980
179regulation of mast cell activation (GO:0033003)2.43229571
180cytokine metabolic process (GO:0042107)2.41541978
181skeletal muscle adaptation (GO:0043501)2.40695599
182regulation of gamma-delta T cell activation (GO:0046643)2.40323939
183sphingosine metabolic process (GO:0006670)2.37963844
184neural tube formation (GO:0001841)2.37817951
185reactive oxygen species biosynthetic process (GO:1903409)2.37233756
186positive regulation of antigen processing and presentation (GO:0002579)2.37172348
187establishment of protein localization to Golgi (GO:0072600)2.37100978
188positive regulation of T-helper cell differentiation (GO:0045624)2.36283024
189* indole-containing compound metabolic process (GO:0042430)2.34652285
190germinal center formation (GO:0002467)2.34160563
191muscle atrophy (GO:0014889)2.31592377
192response to protozoan (GO:0001562)2.30893698

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.88087119
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.14257914
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.75687062
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.18469490
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.07540354
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.79840546
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.10584011
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79628225
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.79612077
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.59028972
11GBX2_23144817_ChIP-Seq_PC3_Human2.49947562
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49298777
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.29952707
14VDR_22108803_ChIP-Seq_LS180_Human2.26698649
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23589642
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16458953
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14447441
18* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1856981
19ER_23166858_ChIP-Seq_MCF-7_Human1.96085150
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92785655
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88924688
22* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81974400
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76152990
24VDR_24787735_ChIP-Seq_THP-1_Human1.74107596
25AHR_22903824_ChIP-Seq_MCF-7_Human1.73693059
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72336545
27GATA1_22025678_ChIP-Seq_K562_Human1.71172356
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.68618102
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68600902
30STAT3_23295773_ChIP-Seq_U87_Human1.68019981
31* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66308448
32TP53_16413492_ChIP-PET_HCT116_Human1.64504666
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63806770
34ZNF274_21170338_ChIP-Seq_K562_Hela1.63409929
35HTT_18923047_ChIP-ChIP_STHdh_Human1.61502734
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60679300
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56387007
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51674322
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50934270
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.48559761
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.46953599
42IGF1R_20145208_ChIP-Seq_DFB_Human1.45935427
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43637144
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42503442
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42393647
46* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40541051
47TCF4_23295773_ChIP-Seq_U87_Human1.39002182
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38396706
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.36881763
50* P300_19829295_ChIP-Seq_ESCs_Human1.36265258
51SMAD4_21799915_ChIP-Seq_A2780_Human1.35614280
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34176302
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33959951
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32366322
55CBP_20019798_ChIP-Seq_JUKART_Human1.32259161
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32259161
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31864367
58SCL_19346495_ChIP-Seq_HPC-7_Human1.31271259
59* HNF4A_19822575_ChIP-Seq_HepG2_Human1.29083114
60* CJUN_26792858_Chip-Seq_BT549_Human1.28331524
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26411182
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.25896311
63* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25106670
64AR_25329375_ChIP-Seq_VCAP_Human1.24213328
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22628056
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22262654
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22262654
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21062279
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19695583
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18947321
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16755081
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16539974
73* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15955480
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15353637
75* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15325616
76RUNX_20019798_ChIP-Seq_JUKART_Human1.13337965
77GATA3_26560356_Chip-Seq_TH2_Human1.13095168
78DROSHA_22980978_ChIP-Seq_HELA_Human1.12640381
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11981357
80AR_21572438_ChIP-Seq_LNCaP_Human1.11901649
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11853659
82CLOCK_20551151_ChIP-Seq_293T_Human1.10760787
83* IRF8_21731497_ChIP-ChIP_J774_Mouse1.10141642
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.09395620
85* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09191080
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.08183888
87EWS_26573619_Chip-Seq_HEK293_Human1.05599087
88TP63_23658742_ChIP-Seq_EP156T_Human1.05473543
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.05437504
90* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04392019
91EZH2_22144423_ChIP-Seq_EOC_Human1.02611787
92TCF4_22108803_ChIP-Seq_LS180_Human1.02160569
93* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02025017
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.01826840
95* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01701891
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00766992
97* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00030063
98MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99514685
99* IRF8_27001747_Chip-Seq_BMDM_Mouse0.99201447
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93483983
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93098676
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90961979
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86115071
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86115071
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84469151
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81194999
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81099902
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79641735
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77972463
110* GATA4_25053715_ChIP-Seq_YYC3_Human0.76385470
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75196252
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74295868
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72653261
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.72164144
115* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71824530
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70513636
117EGR1_19032775_ChIP-ChIP_M12_Human0.68252248
118BP1_19119308_ChIP-ChIP_Hs578T_Human0.66899964
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64324573
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.64289080
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63639494
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62867173
123* TAF15_26573619_Chip-Seq_HEK293_Human0.62810072
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.61296451
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61171501
126STAT1_17558387_ChIP-Seq_HELA_Human0.60323377
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60092855
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59573230
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.59401304
130SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59088452
131CEBPB_22108803_ChIP-Seq_LS180_Human0.57725188
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.55593684
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55544140
134RARB_24833708_ChIP-Seq_LIVER_Mouse0.54413574
135CDX2_20551321_ChIP-Seq_CACO-2_Human0.54348898
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.53176942
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.52937883
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.51994335
139ESET_19884257_ChIP-Seq_ESCs_Mouse0.51253488
140ESR1_15608294_ChIP-ChIP_MCF-7_Human0.51213047
141* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51031636
142CBP_21632823_ChIP-Seq_H3396_Human0.50206712
143* AR_20517297_ChIP-Seq_VCAP_Human0.50186894
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.50094847
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49983709
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49839741
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48603571
148CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48582878
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47619886
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.47521116
151* MYC_19915707_ChIP-ChIP_AK7_Human0.47174623
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.47080173
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45416966
154* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.45401241
155CDX2_22108803_ChIP-Seq_LS180_Human0.44786941
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43610102
157* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.43304791
158BRD4_27068464_Chip-Seq_AML-cells_Mouse0.42547652
159BCAT_22108803_ChIP-Seq_LS180_Human0.41640686
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.41438488
161P53_21459846_ChIP-Seq_SAOS-2_Human0.40513575
162GATA2_19941826_ChIP-Seq_K562_Human0.40044113
163SOX2_20726797_ChIP-Seq_SW620_Human0.39964811
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39850893
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.39684691
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.39665742
167* TAF2_19829295_ChIP-Seq_ESCs_Human0.39551772
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.39290014
169FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39105271
170LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.38806157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.04257313
2MP0005360_urolithiasis7.31121627
3MP0005085_abnormal_gallbladder_physiolo6.30457566
4MP0005365_abnormal_bile_salt5.94634259
5MP0008875_abnormal_xenobiotic_pharmacok4.74442176
6MP0003806_abnormal_nucleotide_metabolis4.03626526
7MP0003252_abnormal_bile_duct3.89250472
8MP0000569_abnormal_digit_pigmentation3.73893972
9MP0010329_abnormal_lipoprotein_level3.40351174
10MP0009840_abnormal_foam_cell3.09418051
11MP0003303_peritoneal_inflammation2.99412533
12MP0003646_muscle_fatigue2.94967278
13MP0005083_abnormal_biliary_tract2.89375782
14MP0003195_calcinosis2.83740165
15MP0008057_abnormal_DNA_replication2.73672427
16MP0005332_abnormal_amino_acid2.66750698
17MP0005167_abnormal_blood-brain_barrier2.50562268
18MP0002138_abnormal_hepatobiliary_system2.46588483
19MP0001666_abnormal_nutrient_absorption2.42382637
20MP0005310_abnormal_salivary_gland2.34747433
21MP0003191_abnormal_cellular_cholesterol2.29276960
22MP0005671_abnormal_response_to2.14942795
23MP0004019_abnormal_vitamin_homeostasis2.13097175
24MP0000609_abnormal_liver_physiology2.12428851
25MP0002118_abnormal_lipid_homeostasis2.01767035
26MP0001501_abnormal_sleep_pattern1.95797352
27MP0003950_abnormal_plasma_membrane1.91810996
28MP0006054_spinal_hemorrhage1.88737462
29MP0000371_diluted_coat_color1.84407528
30MP0002452_abnormal_antigen_presenting1.82908359
31MP0000383_abnormal_hair_follicle1.82727176
32MP0003868_abnormal_feces_composition1.81447464
33MP0005319_abnormal_enzyme/_coenzyme1.77729619
34MP0004043_abnormal_pH_regulation1.75152330
35MP0002332_abnormal_exercise_endurance1.75127136
36MP0003045_fibrosis1.73048899
37MP0001764_abnormal_homeostasis1.67714821
38MP0004510_myositis1.65735514
39MP0009697_abnormal_copulation1.60317616
40MP0005451_abnormal_body_composition1.59716903
41MP0005584_abnormal_enzyme/coenzyme_acti1.57012524
42MP0000427_abnormal_hair_cycle1.44724192
43MP0009764_decreased_sensitivity_to1.43290012
44MP0003011_delayed_dark_adaptation1.40089435
45MP0009046_muscle_twitch1.38820682
46MP0002254_reproductive_system_inflammat1.38784596
47MP0003186_abnormal_redox_activity1.36317036
48MP0001819_abnormal_immune_cell1.30002201
49MP0002420_abnormal_adaptive_immunity1.28932806
50MP0002837_dystrophic_cardiac_calcinosis1.26834628
51MP0010155_abnormal_intestine_physiology1.23960827
52MP0003172_abnormal_lysosome_physiology1.23150950
53MP0010678_abnormal_skin_adnexa1.21672729
54MP0003300_gastrointestinal_ulcer1.21301142
55MP0009643_abnormal_urine_homeostasis1.20897845
56MP0001533_abnormal_skeleton_physiology1.20313358
57MP0003183_abnormal_peptide_metabolism1.19012590
58MP0005647_abnormal_sex_gland1.17763352
59MP0002998_abnormal_bone_remodeling1.17546685
60MP0008469_abnormal_protein_level1.16139676
61MP0003656_abnormal_erythrocyte_physiolo1.15356099
62MP0000598_abnormal_liver_morphology1.14369902
63MP0009763_increased_sensitivity_to1.13668575
64MP0002405_respiratory_system_inflammati1.13598071
65MP0000604_amyloidosis1.12630865
66MP0002876_abnormal_thyroid_physiology1.10215264
67MP0001545_abnormal_hematopoietic_system1.09435153
68MP0005397_hematopoietic_system_phenotyp1.09435153
69MP0000343_altered_response_to1.07994814
70MP0001873_stomach_inflammation1.03606887
71MP0009278_abnormal_bone_marrow1.03604700
72MP0008961_abnormal_basal_metabolism0.97252286
73MP0010386_abnormal_urinary_bladder0.96988470
74MP0003436_decreased_susceptibility_to0.96156474
75MP0001835_abnormal_antigen_presentation0.91631125
76MP0002693_abnormal_pancreas_physiology0.91412506
77MP0003633_abnormal_nervous_system0.90275660
78MP0005551_abnormal_eye_electrophysiolog0.89901275
79MP0003724_increased_susceptibility_to0.88885661
80MP0009642_abnormal_blood_homeostasis0.88615948
81MP0005636_abnormal_mineral_homeostasis0.87836524
82MP0000716_abnormal_immune_system0.86546657
83MP0005410_abnormal_fertilization0.86183422
84MP0006082_CNS_inflammation0.85606590
85MP0003705_abnormal_hypodermis_morpholog0.85589371
86MP0005174_abnormal_tail_pigmentation0.83849559
87MP0009785_altered_susceptibility_to0.83361314
88MP0001661_extended_life_span0.82611643
89MP0009765_abnormal_xenobiotic_induced0.82162278
90MP0005408_hypopigmentation0.81453576
91MP0005084_abnormal_gallbladder_morpholo0.81304707
92MP0005376_homeostasis/metabolism_phenot0.78773778
93MP0005535_abnormal_body_temperature0.78701030
94MP0010368_abnormal_lymphatic_system0.75940321
95MP0005646_abnormal_pituitary_gland0.75933046
96MP0003690_abnormal_glial_cell0.75912826
97MP0008004_abnormal_stomach_pH0.73538520
98MP0005464_abnormal_platelet_physiology0.73456043
99MP0002078_abnormal_glucose_homeostasis0.72831182
100MP0001968_abnormal_touch/_nociception0.71813400
101MP0000230_abnormal_systemic_arterial0.71533523
102MP0001853_heart_inflammation0.71194582
103MP0002971_abnormal_brown_adipose0.69474688
104MP0003879_abnormal_hair_cell0.69340136
105MP0005334_abnormal_fat_pad0.67820001
106MP0004381_abnormal_hair_follicle0.66555521
107MP0002090_abnormal_vision0.66429484
108MP0004782_abnormal_surfactant_physiolog0.66153033
109MP0005670_abnormal_white_adipose0.64970198
110MP0004233_abnormal_muscle_weight0.64679143
111MP0003631_nervous_system_phenotype0.64490228
112MP0006036_abnormal_mitochondrial_physio0.64436954
113MP0002736_abnormal_nociception_after0.64241591
114MP0005025_abnormal_response_to0.62277243
115MP0000685_abnormal_immune_system0.62095527
116MP0002419_abnormal_innate_immunity0.60700241
117MP0005220_abnormal_exocrine_pancreas0.60443241
118MP0001845_abnormal_inflammatory_respons0.59278584
119MP0005266_abnormal_metabolism0.56159375
120MP0002136_abnormal_kidney_physiology0.54573690
121MP0001790_abnormal_immune_system0.54086182
122MP0005387_immune_system_phenotype0.54086182
123MP0003075_altered_response_to0.53362759
124MP0002928_abnormal_bile_duct0.52706267
125MP0004130_abnormal_muscle_cell0.52232519
126MP0005166_decreased_susceptibility_to0.51865229
127MP0001756_abnormal_urination0.50371311
128MP0005448_abnormal_energy_balance0.49707586
129MP0000639_abnormal_adrenal_gland0.49578731
130MP0003329_amyloid_beta_deposits0.48917318
131MP0001800_abnormal_humoral_immune0.48009413
132MP0005395_other_phenotype0.47996373
133MP0008874_decreased_physiological_sensi0.47235853
134MP0006035_abnormal_mitochondrial_morpho0.45156319
135MP0008873_increased_physiological_sensi0.44363586
136MP0003638_abnormal_response/metabolism_0.43879648
137MP0000249_abnormal_blood_vessel0.43068760
138MP0004947_skin_inflammation0.41536312
139MP0002148_abnormal_hypersensitivity_rea0.41166891
140MP0003718_maternal_effect0.40945451
141MP0004883_abnormal_blood_vessel0.39715026
142MP0005248_abnormal_Harderian_gland0.38805718
143MP0009053_abnormal_anal_canal0.38476130
144MP0005164_abnormal_response_to0.38158416
145MP0002723_abnormal_immune_serum0.36523563
146MP0001881_abnormal_mammary_gland0.35684318
147MP0003953_abnormal_hormone_level0.34924172
148MP0002168_other_aberrant_phenotype0.34855695
149MP0000579_abnormal_nail_morphology0.34811926
150MP0009115_abnormal_fat_cell0.34480240
151MP0005000_abnormal_immune_tolerance0.34324869
152MP0005058_abnormal_lysosome_morphology0.33007024

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.26719063
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19943226
3Deep venous thrombosis (HP:0002625)7.16400867
4Prolonged partial thromboplastin time (HP:0003645)6.79980465
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.54313709
6Xanthomatosis (HP:0000991)6.09312962
7Hypobetalipoproteinemia (HP:0003563)6.07412655
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.76852479
9Complement deficiency (HP:0004431)5.59741472
10Increased cerebral lipofuscin (HP:0011813)5.58178039
11Genetic anticipation (HP:0003743)5.56785539
12Hyperlipoproteinemia (HP:0010980)5.28093787
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)5.14279854
14Joint hemorrhage (HP:0005261)5.12530608
15Epidermoid cyst (HP:0200040)4.62950158
16Hypolipoproteinemia (HP:0010981)4.49694532
17Abnormality of the common coagulation pathway (HP:0010990)4.41833236
18Hyperammonemia (HP:0001987)4.37776753
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23748407
20Hyperglycinemia (HP:0002154)4.22575611
21Fat malabsorption (HP:0002630)4.19670012
22Abnormality of methionine metabolism (HP:0010901)4.16955301
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.16097297
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13563366
25Abnormality of complement system (HP:0005339)4.13244756
26Hyperventilation (HP:0002883)4.12260841
27Abnormality of aspartate family amino acid metabolism (HP:0010899)4.02155638
28Abnormality of pyrimidine metabolism (HP:0004353)3.99387182
29Progressive cerebellar ataxia (HP:0002073)3.96939256
30Ketosis (HP:0001946)3.94919048
31Hypoalphalipoproteinemia (HP:0003233)3.90830367
32Gaze-evoked nystagmus (HP:0000640)3.89749209
33Abnormality of liposaccharide metabolism (HP:0010968)3.84855599
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.84855599
35Abnormality of glycolipid metabolism (HP:0010969)3.84855599
36Conjugated hyperbilirubinemia (HP:0002908)3.83996476
37Hyperglycinuria (HP:0003108)3.69833830
38Clumsiness (HP:0002312)3.68719681
39Abnormality of glycine metabolism (HP:0010895)3.68476250
40Abnormality of serine family amino acid metabolism (HP:0010894)3.68476250
41Abnormality of the intrinsic pathway (HP:0010989)3.59832880
42Hypoglycemic coma (HP:0001325)3.58817773
43Hypercholesterolemia (HP:0003124)3.52679568
44Autoimmune thrombocytopenia (HP:0001973)3.44709487
45Recurrent gram-negative bacterial infections (HP:0005420)3.40319192
46Dysmetric saccades (HP:0000641)3.35685691
47Protruding tongue (HP:0010808)3.34522014
48Recurrent bacterial skin infections (HP:0005406)3.34425917
49Myocardial infarction (HP:0001658)3.30953434
50Retrobulbar optic neuritis (HP:0100654)3.26487399
51Optic neuritis (HP:0100653)3.26487399
52Steatorrhea (HP:0002570)3.23414481
53Systemic lupus erythematosus (HP:0002725)3.21169898
54Fair hair (HP:0002286)3.17841738
55Hyperbilirubinemia (HP:0002904)3.17364484
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13944374
57Abnormality of fatty-acid metabolism (HP:0004359)3.13608605
58Spontaneous abortion (HP:0005268)3.10230638
59Abnormality of nucleobase metabolism (HP:0010932)3.07597331
60Pancreatic cysts (HP:0001737)3.01073908
61Hypochromic microcytic anemia (HP:0004840)3.00984967
62Abnormality of serum amino acid levels (HP:0003112)2.96284663
63Orchitis (HP:0100796)2.92597547
64Vacuolated lymphocytes (HP:0001922)2.91134680
65Delayed CNS myelination (HP:0002188)2.89307873
66Hepatocellular carcinoma (HP:0001402)2.86811962
67Recurrent abscess formation (HP:0002722)2.85367425
68Attenuation of retinal blood vessels (HP:0007843)2.73877233
69Congenital sensorineural hearing impairment (HP:0008527)2.73469713
70Ketoacidosis (HP:0001993)2.72680286
71Stomatitis (HP:0010280)2.71969983
72Skin nodule (HP:0200036)2.69566643
73Vascular calcification (HP:0004934)2.62582319
74Metabolic acidosis (HP:0001942)2.62415571
75Abnormality of purine metabolism (HP:0004352)2.61702405
76Prostate neoplasm (HP:0100787)2.61678581
77Gingival bleeding (HP:0000225)2.61573455
78Mitral stenosis (HP:0001718)2.61268543
79Generalized hypopigmentation of hair (HP:0011358)2.59809397
80Glomerulonephritis (HP:0000099)2.58406146
81Urinary bladder sphincter dysfunction (HP:0002839)2.54416647
82Abnormality of macrophages (HP:0004311)2.46554659
83Dysostosis multiplex (HP:0000943)2.46345560
84Acanthocytosis (HP:0001927)2.46133103
85Hematochezia (HP:0002573)2.41602175
86Myositis (HP:0100614)2.40750690
87Lethargy (HP:0001254)2.40400635
88Hypoglycemic seizures (HP:0002173)2.39131535
89Amyloidosis (HP:0011034)2.34694984
90Dicarboxylic aciduria (HP:0003215)2.32687243
91Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32687243
92Abnormality of polysaccharide metabolism (HP:0011012)2.30542842
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30542842
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30542842
95Spastic diplegia (HP:0001264)2.30417678
96Congenital stationary night blindness (HP:0007642)2.30366391
97Abnormal gallbladder morphology (HP:0012437)2.29646338
98Esophageal varix (HP:0002040)2.29645209
99Irritability (HP:0000737)2.29610140
100Cardiovascular calcification (HP:0011915)2.28998153
101Abnormality of the renal cortex (HP:0011035)2.27736957
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27229217
103Abnormality of alanine metabolism (HP:0010916)2.27229217
104Hyperalaninemia (HP:0003348)2.27229217
105Menorrhagia (HP:0000132)2.24531957
106Neonatal onset (HP:0003623)2.22880560
107Abolished electroretinogram (ERG) (HP:0000550)2.22471060
108Cholelithiasis (HP:0001081)2.21375410
109Thrombophlebitis (HP:0004418)2.21333771
110Cerebral edema (HP:0002181)2.21231105
111Widely spaced teeth (HP:0000687)2.20104621
112Mediastinal lymphadenopathy (HP:0100721)2.19856174
113Abnormality of the hepatic vasculature (HP:0006707)2.17520698
114Pancreatitis (HP:0001733)2.16667365
115True hermaphroditism (HP:0010459)2.15672138
116Mucopolysacchariduria (HP:0008155)2.15535921
117Urinary glycosaminoglycan excretion (HP:0003541)2.15535921
118Loss of speech (HP:0002371)2.15399749
119Gout (HP:0001997)2.14077224
120Keratoconjunctivitis sicca (HP:0001097)2.12915840
121Keratoconjunctivitis (HP:0001096)2.12803495
122Hemorrhage of the eye (HP:0011885)2.12723712
123Pancreatic fibrosis (HP:0100732)2.10999036
124Absent speech (HP:0001344)2.08105003
125Enlarged kidneys (HP:0000105)2.07179585
126Sensorimotor neuropathy (HP:0007141)2.06757596
127Autoimmune hemolytic anemia (HP:0001890)2.06441574
128Inappropriate behavior (HP:0000719)2.05781858
129Tubular atrophy (HP:0000092)2.05626889
130Abnormality of T cell number (HP:0011839)2.05458035
131Aplasia/Hypoplasia of the tibia (HP:0005772)2.04832689
132Chronic hepatic failure (HP:0100626)2.03103125
133Febrile seizures (HP:0002373)2.02335063
134Generalized aminoaciduria (HP:0002909)2.01871706
135Abnormal gallbladder physiology (HP:0012438)2.00770584
136Cholecystitis (HP:0001082)2.00770584
137Hemoptysis (HP:0002105)2.00769486
138Hydroxyprolinuria (HP:0003080)2.00765457
139Abnormality of proline metabolism (HP:0010907)2.00765457
140Renal cortical cysts (HP:0000803)2.00240078
141Hypophosphatemic rickets (HP:0004912)1.99710031
142Malnutrition (HP:0004395)1.99274582
143Absence seizures (HP:0002121)1.98562860
144Dialeptic seizures (HP:0011146)1.98547623
145Rickets (HP:0002748)1.98114060
146Progressive visual loss (HP:0000529)1.96865322
147Opisthotonus (HP:0002179)1.96055485
148Disinhibition (HP:0000734)1.95888699
149Abnormal enzyme/coenzyme activity (HP:0012379)1.95095498
150Eczematoid dermatitis (HP:0000976)1.94950260
151Nephritis (HP:0000123)1.94655974
152Abnormality of iron homeostasis (HP:0011031)1.93031416
153Bony spicule pigmentary retinopathy (HP:0007737)1.92396254
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91883998
155Abnormality of the periventricular white matter (HP:0002518)1.91663405
156Portal hypertension (HP:0001409)1.91260548
157Macroglossia (HP:0000158)1.91166000
158Abnormality of binocular vision (HP:0011514)1.91140594
159Diplopia (HP:0000651)1.91140594
160Vomiting (HP:0002013)1.90491076
161Facial diplegia (HP:0001349)1.89558620
162Alkalosis (HP:0001948)1.89362084
163Impaired smooth pursuit (HP:0007772)1.89177855
164Poikilocytosis (HP:0004447)1.88535255
165Abnormality of transition element cation homeostasis (HP:0011030)1.88448469
166Decreased circulating renin level (HP:0003351)1.87352175
167Hyperinsulinemic hypoglycemia (HP:0000825)1.87264091
168Elevated hepatic transaminases (HP:0002910)1.86585899
169Pulmonary embolism (HP:0002204)1.86415572
170Macular degeneration (HP:0000608)1.86180880
171Abnormality of the gallbladder (HP:0005264)1.86102214
172Late onset (HP:0003584)1.85924047
173Recurrent skin infections (HP:0001581)1.85601685
174Brushfield spots (HP:0001088)1.84596319
175Stomach cancer (HP:0012126)1.84301914
176Progressive inability to walk (HP:0002505)1.83974680
177T lymphocytopenia (HP:0005403)1.83361150
178Central scotoma (HP:0000603)1.81027160
179Elevated alkaline phosphatase (HP:0003155)1.80369070
180Gangrene (HP:0100758)1.79918623
181Recurrent fungal infections (HP:0002841)1.79643832
182Pulmonary infiltrates (HP:0002113)1.76639418
183Cystic liver disease (HP:0006706)1.76061167
184Inability to walk (HP:0002540)1.75283998
185Arterial thrombosis (HP:0004420)1.72916751
186Abnormality of the renal medulla (HP:0100957)1.72780904
187Joint swelling (HP:0001386)1.71382104
188Vasculitis (HP:0002633)1.70582898
189Abnormality of alkaline phosphatase activity (HP:0004379)1.70193097
190Molar tooth sign on MRI (HP:0002419)1.69065638
191Abnormality of midbrain morphology (HP:0002418)1.69065638
192Furrowed tongue (HP:0000221)1.68965997
193Global brain atrophy (HP:0002283)1.67268824
194Abnormality of the prostate (HP:0008775)1.67035366
195Elevated erythrocyte sedimentation rate (HP:0003565)1.65171413
196IgA deficiency (HP:0002720)1.64775190
197Abnormality of the pericardium (HP:0001697)1.62999115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.44877667
2ACVR1B4.66602056
3FGFR44.14400343
4SIK13.93309839
5ERN13.85071917
6MAP3K143.16622247
7TAOK33.11875172
8INSRR2.92487427
9ERBB42.80829147
10TYK22.63092584
11BMPR1B2.53362078
12BLK2.47285154
13GRK72.06310682
14TBK12.04505414
15NEK92.00550391
16MST1R1.90208000
17MAP3K131.84321743
18PBK1.80629868
19MAPK111.75409731
20IRAK31.68580959
21JAK11.66961817
22PIK3CG1.64003828
23MAP2K41.61692927
24MATK1.57654847
25FLT31.51590289
26ABL21.50859080
27OXSR11.50452928
28TXK1.44239740
29JAK21.38397196
30IKBKE1.37641530
31IKBKB1.33921808
32DDR21.32573038
33TRPM71.26602255
34JAK31.25457635
35AKT31.24125056
36PTK61.24047962
37CSK1.18190357
38DAPK21.16547619
39CSF1R1.13477252
40FRK1.13086979
41GRK61.10533153
42EPHB11.09033303
43PRKAA21.08044767
44EPHA31.06577046
45TGFBR11.05868050
46MAP3K101.01031251
47MAP3K71.00917495
48MELK0.97169461
49LATS10.96421054
50CHUK0.94331066
51PRKCQ0.93964724
52CAMKK20.93582710
53MAPK40.93498243
54ADRBK10.92831022
55PDK20.90419600
56KDR0.89981943
57PKN20.89546456
58PRKCZ0.87342365
59MARK30.86803874
60MKNK20.85943123
61PKN10.85771496
62CDC42BPA0.84941795
63IRAK40.83637971
64ZAK0.82493294
65FGFR20.82313398
66IRAK10.81817446
67MAP4K10.80188233
68MAPK120.75446595
69PIK3CA0.74796789
70SYK0.74739042
71FGFR30.74634694
72GRK10.72597121
73TEC0.71914077
74CAMK1G0.71542193
75MAP2K30.70552160
76MAPKAPK30.69871205
77MAPK150.69666612
78ERBB20.69493742
79FER0.68824628
80PRKACG0.67960095
81PINK10.66946015
82TNK20.66710002
83TRIB30.65760065
84MAP2K60.63616256
85CDK120.60856590
86KIT0.60840615
87CAMK1D0.58507717
88BMPR20.58265700
89BTK0.57126158
90LYN0.56559193
91CDK60.56020389
92SIK20.55420089
93STK390.54159147
94CAMK2G0.52868189
95MAPK70.52655416
96IGF1R0.52185809
97MAP3K50.52099894
98LCK0.51060724
99NLK0.50680471
100RIPK40.50556776
101IRAK20.50093084
102PRKAA10.50067997
103PDPK10.48975475
104TIE10.48651004
105HCK0.48342389
106DYRK1B0.47828807
107STK38L0.47481511
108GSK3A0.46154287
109ABL10.45141664
110EIF2AK20.44748176
111MET0.44725523
112TAOK20.44108934
113NEK60.43063660
114RPS6KA60.42548628
115STK40.42464414
116MAP3K30.42353453
117PRKCE0.41254218
118TGFBR20.39838354
119SGK30.39751464
120NUAK10.39410155
121STK380.38618534
122PTK2B0.38531822
123TLK10.37430582
124SGK20.37063210
125ADRBK20.37016365
126EGFR0.36845122
127PIM10.36839003
128MAPK130.36410076
129NTRK30.36179148
130PDK10.35650689
131RPS6KB20.34798776
132PDGFRB0.34574146
133MAP4K20.34124881
134PRKCD0.33382302
135ITK0.32914245
136STK30.30369776
137MAPKAPK50.29809302
138MKNK10.29198475
139CDK40.28831518
140ZAP700.28222544
141TYRO30.27930831
142BMX0.27536645
143CAMK40.26894247
144WNK40.26611977
145FGR0.26440531
146NME20.24676379
147MAPK30.24366193

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.71335160
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.70651754
3Nitrogen metabolism_Homo sapiens_hsa009103.49176895
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31433869
5Arginine biosynthesis_Homo sapiens_hsa002203.07958078
6Complement and coagulation cascades_Homo sapiens_hsa046102.90729683
7* Tryptophan metabolism_Homo sapiens_hsa003802.68798991
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59475691
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48618264
10Asthma_Homo sapiens_hsa053102.46932520
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46060390
12Fatty acid degradation_Homo sapiens_hsa000712.39201997
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34037701
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30183975
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20389194
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20335245
17Rheumatoid arthritis_Homo sapiens_hsa053232.19197138
18Peroxisome_Homo sapiens_hsa041462.13320157
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10661917
20Staphylococcus aureus infection_Homo sapiens_hsa051502.05253073
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.03442913
22Butanoate metabolism_Homo sapiens_hsa006502.01653902
23Histidine metabolism_Homo sapiens_hsa003401.99071213
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.95737895
25Chemical carcinogenesis_Homo sapiens_hsa052041.90661574
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88100156
27Lysosome_Homo sapiens_hsa041421.87402480
28Autoimmune thyroid disease_Homo sapiens_hsa053201.86126917
29PPAR signaling pathway_Homo sapiens_hsa033201.83641452
30TNF signaling pathway_Homo sapiens_hsa046681.82636663
31Propanoate metabolism_Homo sapiens_hsa006401.81088398
32Retinol metabolism_Homo sapiens_hsa008301.74984565
33Type I diabetes mellitus_Homo sapiens_hsa049401.74831118
34beta-Alanine metabolism_Homo sapiens_hsa004101.73634777
35Osteoclast differentiation_Homo sapiens_hsa043801.72865585
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.71407295
37Caffeine metabolism_Homo sapiens_hsa002321.70111245
38Fatty acid metabolism_Homo sapiens_hsa012121.69441834
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69341193
40Phenylalanine metabolism_Homo sapiens_hsa003601.67073141
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66919817
42Tuberculosis_Homo sapiens_hsa051521.54756442
43Selenocompound metabolism_Homo sapiens_hsa004501.50993100
44Tyrosine metabolism_Homo sapiens_hsa003501.48854347
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47908923
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45789846
47Bile secretion_Homo sapiens_hsa049761.42670014
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38905672
49Fatty acid elongation_Homo sapiens_hsa000621.30179254
50Influenza A_Homo sapiens_hsa051641.29167875
51Steroid biosynthesis_Homo sapiens_hsa001001.27309220
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26232754
53Sulfur metabolism_Homo sapiens_hsa009201.25587520
54Starch and sucrose metabolism_Homo sapiens_hsa005001.25268935
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.24129149
56ABC transporters_Homo sapiens_hsa020101.23035680
57Other glycan degradation_Homo sapiens_hsa005111.20983711
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.20427878
59Pyruvate metabolism_Homo sapiens_hsa006201.18947060
60Folate biosynthesis_Homo sapiens_hsa007901.17339155
61Sphingolipid metabolism_Homo sapiens_hsa006001.16167702
62Toxoplasmosis_Homo sapiens_hsa051451.14515312
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13944894
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05538196
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04668369
66Fat digestion and absorption_Homo sapiens_hsa049751.03829680
67Biosynthesis of amino acids_Homo sapiens_hsa012301.01970315
68Hematopoietic cell lineage_Homo sapiens_hsa046401.00505697
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.97693652
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95606571
71Antigen processing and presentation_Homo sapiens_hsa046120.93813007
72Carbon metabolism_Homo sapiens_hsa012000.93805237
73Dorso-ventral axis formation_Homo sapiens_hsa043200.93687703
74Arginine and proline metabolism_Homo sapiens_hsa003300.91798092
75Ether lipid metabolism_Homo sapiens_hsa005650.91695943
76Chemokine signaling pathway_Homo sapiens_hsa040620.91536340
77Vitamin digestion and absorption_Homo sapiens_hsa049770.90540108
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87591022
79Type II diabetes mellitus_Homo sapiens_hsa049300.85946263
80Vitamin B6 metabolism_Homo sapiens_hsa007500.85038453
81Mineral absorption_Homo sapiens_hsa049780.84776458
82Herpes simplex infection_Homo sapiens_hsa051680.82784895
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81069217
84Measles_Homo sapiens_hsa051620.80464455
85Sulfur relay system_Homo sapiens_hsa041220.79302463
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.78356990
87B cell receptor signaling pathway_Homo sapiens_hsa046620.75577394
88Lysine degradation_Homo sapiens_hsa003100.74398784
89One carbon pool by folate_Homo sapiens_hsa006700.74276577
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70645062
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64314941
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64203165
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63698174
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62746130
95Phototransduction_Homo sapiens_hsa047440.62729479
96Morphine addiction_Homo sapiens_hsa050320.62234076
97Glycerolipid metabolism_Homo sapiens_hsa005610.58523505
98Viral myocarditis_Homo sapiens_hsa054160.57723648
99Prolactin signaling pathway_Homo sapiens_hsa049170.57693713
100Glutathione metabolism_Homo sapiens_hsa004800.57655882
101Platelet activation_Homo sapiens_hsa046110.56318759
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54666086
103Fatty acid biosynthesis_Homo sapiens_hsa000610.52972746
104Phagosome_Homo sapiens_hsa041450.52320237
105Prion diseases_Homo sapiens_hsa050200.50810808
106Taste transduction_Homo sapiens_hsa047420.50798764
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49630963
108Pentose phosphate pathway_Homo sapiens_hsa000300.47355132
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44855940
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43589514
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42735738
112Calcium signaling pathway_Homo sapiens_hsa040200.42580399
113Primary immunodeficiency_Homo sapiens_hsa053400.42552461
114Salmonella infection_Homo sapiens_hsa051320.42348268
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42240123
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42071227
117Nicotine addiction_Homo sapiens_hsa050330.41686950
118* Metabolic pathways_Homo sapiens_hsa011000.40658754
119Hepatitis B_Homo sapiens_hsa051610.39900635
120Olfactory transduction_Homo sapiens_hsa047400.39691985
121T cell receptor signaling pathway_Homo sapiens_hsa046600.39597047
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.39143072
123Salivary secretion_Homo sapiens_hsa049700.38997970
124Homologous recombination_Homo sapiens_hsa034400.38942293
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.27056636
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22835507
127Insulin resistance_Homo sapiens_hsa049310.21029562
128Linoleic acid metabolism_Homo sapiens_hsa005910.17091614
129Galactose metabolism_Homo sapiens_hsa000520.15474197
130Fructose and mannose metabolism_Homo sapiens_hsa000510.13431725
131African trypanosomiasis_Homo sapiens_hsa051430.12943554
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11989280
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10513463
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09283609
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.08754884
136Graft-versus-host disease_Homo sapiens_hsa053320.07235234
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.04104404
138Allograft rejection_Homo sapiens_hsa053300.00998238
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.00657215
140Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1479288
141Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1426549
142Regulation of autophagy_Homo sapiens_hsa04140-0.1423844
143Leishmaniasis_Homo sapiens_hsa05140-0.1422361
144Legionellosis_Homo sapiens_hsa05134-0.1208291
145Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1200818
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1184819
147Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.1165253
148Malaria_Homo sapiens_hsa05144-0.1128386
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1063315
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0797780
151AMPK signaling pathway_Homo sapiens_hsa04152-0.0781686
152Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0744470
153Hepatitis C_Homo sapiens_hsa05160-0.0502698
154Glucagon signaling pathway_Homo sapiens_hsa04922-0.0191915
155Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0028835
156Pertussis_Homo sapiens_hsa05133-0.0011217

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