L3HYPDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.91949484
2L-phenylalanine catabolic process (GO:0006559)6.91949484
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.67721968
4L-phenylalanine metabolic process (GO:0006558)6.67721968
5aromatic amino acid family catabolic process (GO:0009074)6.39628066
6tryptophan catabolic process (GO:0006569)5.87742307
7indole-containing compound catabolic process (GO:0042436)5.87742307
8indolalkylamine catabolic process (GO:0046218)5.87742307
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.57105932
10glyoxylate metabolic process (GO:0046487)5.56860697
11tryptophan metabolic process (GO:0006568)5.52514040
12kynurenine metabolic process (GO:0070189)5.26766392
13bile acid biosynthetic process (GO:0006699)5.20100137
14homocysteine metabolic process (GO:0050667)5.08590042
15high-density lipoprotein particle remodeling (GO:0034375)4.97707321
16protein carboxylation (GO:0018214)4.97412146
17peptidyl-glutamic acid carboxylation (GO:0017187)4.97412146
18sulfur amino acid catabolic process (GO:0000098)4.92669407
19cysteine metabolic process (GO:0006534)4.84115019
20serine family amino acid catabolic process (GO:0009071)4.78206323
21alpha-linolenic acid metabolic process (GO:0036109)4.72231797
22aromatic amino acid family metabolic process (GO:0009072)4.67802266
23DNA double-strand break processing (GO:0000729)4.67459946
24amino-acid betaine metabolic process (GO:0006577)4.65852969
25lysine metabolic process (GO:0006553)4.62671521
26lysine catabolic process (GO:0006554)4.62671521
27urea cycle (GO:0000050)4.62444868
28urea metabolic process (GO:0019627)4.62444868
29regulation of fibrinolysis (GO:0051917)4.60351984
30negative regulation of fibrinolysis (GO:0051918)4.56738411
31cellular biogenic amine catabolic process (GO:0042402)4.55104305
32amine catabolic process (GO:0009310)4.55104305
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52938833
34complement activation, alternative pathway (GO:0006957)4.44705895
35alpha-amino acid catabolic process (GO:1901606)4.44464425
36tyrosine metabolic process (GO:0006570)4.44315608
37regulation of protein activation cascade (GO:2000257)4.43838340
38regulation of cholesterol esterification (GO:0010872)4.39855784
39nitrogen cycle metabolic process (GO:0071941)4.37234469
40regulation of triglyceride catabolic process (GO:0010896)4.37055046
41plasma lipoprotein particle remodeling (GO:0034369)4.36365473
42protein-lipid complex remodeling (GO:0034368)4.36365473
43macromolecular complex remodeling (GO:0034367)4.36365473
44reverse cholesterol transport (GO:0043691)4.33376551
45bile acid metabolic process (GO:0008206)4.32305943
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.29946981
47acylglycerol homeostasis (GO:0055090)4.26224251
48triglyceride homeostasis (GO:0070328)4.26224251
49aggressive behavior (GO:0002118)4.24803657
50indolalkylamine metabolic process (GO:0006586)4.18312625
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.17332258
52regulation of complement activation (GO:0030449)4.14381693
53cellular amino acid catabolic process (GO:0009063)4.12164683
54coenzyme catabolic process (GO:0009109)4.10887418
55cellular glucuronidation (GO:0052695)4.10604535
56short-chain fatty acid metabolic process (GO:0046459)4.08758927
57plasma lipoprotein particle clearance (GO:0034381)4.02799123
58aldehyde catabolic process (GO:0046185)4.02665671
59cellular ketone body metabolic process (GO:0046950)4.01939420
60response to nitrosative stress (GO:0051409)3.97521976
61branched-chain amino acid catabolic process (GO:0009083)3.92574824
62fatty acid beta-oxidation (GO:0006635)3.89052723
63phospholipid efflux (GO:0033700)3.87906819
64base-excision repair, AP site formation (GO:0006285)3.87847214
65negative regulation of sterol transport (GO:0032372)3.85097007
66negative regulation of cholesterol transport (GO:0032375)3.85097007
67serine family amino acid metabolic process (GO:0009069)3.84456738
68L-methionine biosynthetic process (GO:0071265)3.83051012
69amino acid salvage (GO:0043102)3.83051012
70L-methionine salvage (GO:0071267)3.83051012
71mannosylation (GO:0097502)3.82482059
72peptidyl-histidine modification (GO:0018202)3.78507132
73uronic acid metabolic process (GO:0006063)3.77984964
74glucuronate metabolic process (GO:0019585)3.77984964
75carboxylic acid catabolic process (GO:0046395)3.77948641
76organic acid catabolic process (GO:0016054)3.77948641
77fatty acid oxidation (GO:0019395)3.76936058
78low-density lipoprotein particle remodeling (GO:0034374)3.75499109
79carnitine metabolic process (GO:0009437)3.75036220
80rRNA modification (GO:0000154)3.73624148
81lipid oxidation (GO:0034440)3.72779758
82ubiquinone biosynthetic process (GO:0006744)3.70219925
83imidazole-containing compound metabolic process (GO:0052803)3.69201437
84cofactor catabolic process (GO:0051187)3.68687608
85fibrinolysis (GO:0042730)3.67825917
86acetyl-CoA metabolic process (GO:0006084)3.67036508
87serine family amino acid biosynthetic process (GO:0009070)3.66097067
88negative regulation of lipase activity (GO:0060192)3.65094672
89arginine metabolic process (GO:0006525)3.65059971
90glycine metabolic process (GO:0006544)3.64893233
91NAD biosynthetic process (GO:0009435)3.61033953
92drug catabolic process (GO:0042737)3.58221745
93benzene-containing compound metabolic process (GO:0042537)3.57266132
94monocarboxylic acid catabolic process (GO:0072329)3.56733177
95glutamate metabolic process (GO:0006536)3.56576997
96cholesterol efflux (GO:0033344)3.56328304
97fatty acid catabolic process (GO:0009062)3.56104372
98cellular modified amino acid catabolic process (GO:0042219)3.55540157
99regulation of bile acid biosynthetic process (GO:0070857)3.55391497
100bile acid and bile salt transport (GO:0015721)3.52226715
101preassembly of GPI anchor in ER membrane (GO:0016254)3.52156030
102branched-chain amino acid metabolic process (GO:0009081)3.50596038
103positive regulation of digestive system process (GO:0060456)3.46569859
104ketone body metabolic process (GO:1902224)3.46406049
105blood coagulation, intrinsic pathway (GO:0007597)3.46105794
106biotin metabolic process (GO:0006768)3.46064551
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.45684330
108nicotinamide nucleotide biosynthetic process (GO:0019359)3.45596679
109pyridine nucleotide biosynthetic process (GO:0019363)3.45596679
110epoxygenase P450 pathway (GO:0019373)3.45095469
111ubiquinone metabolic process (GO:0006743)3.45011294
112positive regulation of lipid catabolic process (GO:0050996)3.44050376
113very-low-density lipoprotein particle assembly (GO:0034379)3.43848780
114daunorubicin metabolic process (GO:0044597)3.41560464
115polyketide metabolic process (GO:0030638)3.41560464
116doxorubicin metabolic process (GO:0044598)3.41560464
117valine metabolic process (GO:0006573)3.39299611
118parental behavior (GO:0060746)3.37643169
119pyrimidine nucleotide catabolic process (GO:0006244)3.37579216
120rRNA methylation (GO:0031167)3.37220236
121flavonoid metabolic process (GO:0009812)3.36854517
122aminoglycoside antibiotic metabolic process (GO:0030647)3.36557318
123DNA integration (GO:0015074)3.34622539
124cholesterol homeostasis (GO:0042632)3.31936596
125GPI anchor metabolic process (GO:0006505)3.30828016
126replication fork processing (GO:0031297)3.29743096
127RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23209156
128positive regulation of prostaglandin secretion (GO:0032308)3.20409593
129GPI anchor biosynthetic process (GO:0006506)3.17238391
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16261314
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15881213
132deoxyribose phosphate catabolic process (GO:0046386)3.13938877
133mitochondrial RNA metabolic process (GO:0000959)3.11144471
134axoneme assembly (GO:0035082)3.11111817
135quinone metabolic process (GO:1901661)3.08112975
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07641158
137xenobiotic catabolic process (GO:0042178)3.02404448
138ADP metabolic process (GO:0046031)3.00956419
139lipopolysaccharide biosynthetic process (GO:0009103)3.00644567
140quinone biosynthetic process (GO:1901663)2.99588553
141maternal behavior (GO:0042711)2.98662215
142purine nucleotide salvage (GO:0032261)2.97402342
143dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.96941058
144deoxyribonucleotide catabolic process (GO:0009264)2.96110785
145positive regulation of vasculogenesis (GO:2001214)2.95952370
146platelet dense granule organization (GO:0060155)2.94085624
147DNA deamination (GO:0045006)2.93124630
148metallo-sulfur cluster assembly (GO:0031163)2.89816558
149iron-sulfur cluster assembly (GO:0016226)2.89816558
150lipopolysaccharide metabolic process (GO:0008653)2.88686727
151histone H2A acetylation (GO:0043968)2.88409456
152positive regulation of icosanoid secretion (GO:0032305)2.87249649
153DNA catabolic process, exonucleolytic (GO:0000738)2.86179664
154protein hydroxylation (GO:0018126)2.84979715
155protein complex biogenesis (GO:0070271)2.84479467
156C-terminal protein lipidation (GO:0006501)2.78962013
157definitive hemopoiesis (GO:0060216)2.78790072
158AMP metabolic process (GO:0046033)2.72920708
159methionine biosynthetic process (GO:0009086)2.72630784
160double-strand break repair via homologous recombination (GO:0000724)2.68248051
161rRNA catabolic process (GO:0016075)2.65103170
162recombinational repair (GO:0000725)2.64812295
163mitochondrial respiratory chain complex assembly (GO:0033108)2.64139987
164tyrosine phosphorylation of STAT protein (GO:0007260)2.62935874
165regulation of meiosis I (GO:0060631)2.62863064
166cytochrome complex assembly (GO:0017004)2.61203481
167mitochondrial DNA replication (GO:0006264)2.60265501
168negative regulation of nitric-oxide synthase activity (GO:0051001)2.59419035
169maturation of 5.8S rRNA (GO:0000460)2.58834601
170epithelial cilium movement (GO:0003351)2.58147368
171negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.57787751
172respiratory chain complex IV assembly (GO:0008535)2.56731534
173negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.56056310
174transcription from mitochondrial promoter (GO:0006390)2.55192418
175pseudouridine synthesis (GO:0001522)2.55090951
176maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.53443086
177positive regulation of catecholamine secretion (GO:0033605)2.52450700
178toxin transport (GO:1901998)2.52275511
179mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51124056
180mitochondrial respiratory chain complex I assembly (GO:0032981)2.51124056
181NADH dehydrogenase complex assembly (GO:0010257)2.51124056
182regulation of prostaglandin secretion (GO:0032306)2.48380703
183positive regulation of fatty acid transport (GO:2000193)2.48138929
184ribosome assembly (GO:0042255)2.47266243
185postreplication repair (GO:0006301)2.46777276
186adenosine metabolic process (GO:0046085)2.45213379
187regulation of skeletal muscle contraction (GO:0014819)2.44870239
188photoreceptor cell maintenance (GO:0045494)2.44527549
189deoxyribose phosphate metabolic process (GO:0019692)2.43326420
190seminiferous tubule development (GO:0072520)2.42796238
191proteasome assembly (GO:0043248)2.42630362
192intraciliary transport (GO:0042073)2.41399276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.65089855
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.73858667
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39704393
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48627150
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.30790843
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.17898257
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41131102
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.31632199
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44387924
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.35297937
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.30964716
12ZNF274_21170338_ChIP-Seq_K562_Hela3.30909538
13IGF1R_20145208_ChIP-Seq_DFB_Human2.88867355
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.87606216
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.83968462
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69226880
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.61446535
18FUS_26573619_Chip-Seq_HEK293_Human2.51997951
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36751973
20VDR_23849224_ChIP-Seq_CD4+_Human2.33476633
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27828571
22ELK1_19687146_ChIP-ChIP_HELA_Human2.21727227
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16717714
24FOXP3_21729870_ChIP-Seq_TREG_Human2.14171522
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11978402
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.11495143
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11032963
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.10146130
29GATA1_22025678_ChIP-Seq_K562_Human2.08696061
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95429001
31MYC_18940864_ChIP-ChIP_HL60_Human1.94513559
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.92525889
33EWS_26573619_Chip-Seq_HEK293_Human1.92314297
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84324698
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82799563
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79932077
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79662731
38VDR_22108803_ChIP-Seq_LS180_Human1.77598900
39ER_23166858_ChIP-Seq_MCF-7_Human1.77060756
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.73904853
41GBX2_23144817_ChIP-Seq_PC3_Human1.72239774
42HTT_18923047_ChIP-ChIP_STHdh_Human1.69973871
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65614424
44TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.63895163
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60299899
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53921074
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.51986496
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49184369
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43556073
50CBP_20019798_ChIP-Seq_JUKART_Human1.43556073
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36274747
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35946414
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35618502
54GATA3_26560356_Chip-Seq_TH2_Human1.35131944
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32989385
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.32989385
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32581235
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31446693
59CJUN_26792858_Chip-Seq_BT549_Human1.29809463
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29430808
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28432712
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.26983595
63TP53_22573176_ChIP-Seq_HFKS_Human1.26692695
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25538345
65BRD4_25478319_ChIP-Seq_HGPS_Human1.25286751
66GABP_19822575_ChIP-Seq_HepG2_Human1.22582800
67TAF15_26573619_Chip-Seq_HEK293_Human1.22171010
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18170234
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13805558
70STAT3_23295773_ChIP-Seq_U87_Human1.12268545
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.12098853
72BCAT_22108803_ChIP-Seq_LS180_Human1.10423618
73HNF4A_19822575_ChIP-Seq_HepG2_Human1.10377129
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.09281323
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.08965163
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08538606
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08538606
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07830733
79CDX2_22108803_ChIP-Seq_LS180_Human1.07124359
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07118454
81IRF1_19129219_ChIP-ChIP_H3396_Human1.07048710
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06812851
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06453592
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06396104
85DCP1A_22483619_ChIP-Seq_HELA_Human1.05658044
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04950173
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03940121
88SMAD4_21799915_ChIP-Seq_A2780_Human1.03522456
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.02361029
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02078236
91SOX2_19829295_ChIP-Seq_ESCs_Human1.01837447
92NANOG_19829295_ChIP-Seq_ESCs_Human1.01837447
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01636674
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.01489186
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01458234
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.00894708
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.00287472
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99324337
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99045482
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.98386577
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.98260561
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97235538
103TCF4_22108803_ChIP-Seq_LS180_Human0.97087809
104SCL_19346495_ChIP-Seq_HPC-7_Human0.96650660
105CLOCK_20551151_ChIP-Seq_293T_Human0.95772760
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95368750
107CIITA_25753668_ChIP-Seq_RAJI_Human0.94710327
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94549328
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93057451
110TCF4_23295773_ChIP-Seq_U87_Human0.92795243
111PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92781845
112RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92625550
113CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92073934
114P300_19829295_ChIP-Seq_ESCs_Human0.90128206
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89133359
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88590919
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.84072315
118P53_22387025_ChIP-Seq_ESCs_Mouse0.83794824
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82662651
120PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82493709
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82050535
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81647847
123STAT3_18555785_Chip-Seq_ESCs_Mouse0.81003547
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80390039
125ESRRB_18555785_Chip-Seq_ESCs_Mouse0.80280547
126STAT1_17558387_ChIP-Seq_HELA_Human0.79033595
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.78767572
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.78743595
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78290367
130SMAD1_18555785_Chip-Seq_ESCs_Mouse0.78162267
131OCT4_18555785_Chip-Seq_ESCs_Mouse0.77943908
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77910822
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77773142
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.77365142
135AR_20517297_ChIP-Seq_VCAP_Human0.77242245
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.76899162
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.76577111
138P300_18555785_Chip-Seq_ESCs_Mouse0.76311857
139PU1_27457419_Chip-Seq_LIVER_Mouse0.75013400
140ZFX_18555785_Chip-Seq_ESCs_Mouse0.74549110
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74067334
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73796069
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72885827
144TP53_18474530_ChIP-ChIP_U2OS_Human0.72229784
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.71446059
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71385439
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70841164
148NMYC_18555785_Chip-Seq_ESCs_Mouse0.69992119
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.68609348
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.68514231
151PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.67391336
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67331447
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67321973
154SRF_21415370_ChIP-Seq_HL-1_Mouse0.67194418
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.66610330
156BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66562964
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.66186119
158RBPJ_22232070_ChIP-Seq_NCS_Mouse0.66100128
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.65669271
160CMYC_18555785_Chip-Seq_ESCs_Mouse0.65501843
161SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.63312342
162KDM2B_26808549_Chip-Seq_REH_Human0.62799682
163SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.62000956
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61652693
165KLF4_18555785_Chip-Seq_ESCs_Mouse0.61461029
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.61192677
167FOXH1_21741376_ChIP-Seq_EPCs_Human0.60533433
168TP53_20018659_ChIP-ChIP_R1E_Mouse0.60444991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.60984529
2MP0005360_urolithiasis7.29129556
3MP0005085_abnormal_gallbladder_physiolo5.80795497
4MP0005365_abnormal_bile_salt5.69243762
5MP0008875_abnormal_xenobiotic_pharmacok4.35361237
6MP0003806_abnormal_nucleotide_metabolis3.72927324
7MP0003252_abnormal_bile_duct3.53465539
8MP0005332_abnormal_amino_acid3.23588930
9MP0010329_abnormal_lipoprotein_level3.16243479
10MP0003195_calcinosis3.05718167
11MP0008058_abnormal_DNA_repair2.92071979
12MP0004019_abnormal_vitamin_homeostasis2.72517228
13MP0002396_abnormal_hematopoietic_system2.59907272
14MP0000372_irregular_coat_pigmentation2.42538682
15MP0002138_abnormal_hepatobiliary_system2.31589801
16MP0005083_abnormal_biliary_tract2.23687320
17MP0003786_premature_aging2.20376175
18MP0009840_abnormal_foam_cell2.16940803
19MP0005670_abnormal_white_adipose2.08555896
20MP0001666_abnormal_nutrient_absorption2.07349858
21MP0003011_delayed_dark_adaptation2.05753601
22MP0000566_synostosis2.04391918
23MP0006072_abnormal_retinal_apoptosis2.03715199
24MP0002118_abnormal_lipid_homeostasis1.98361089
25MP0005397_hematopoietic_system_phenotyp1.93737661
26MP0001545_abnormal_hematopoietic_system1.93737661
27MP0009697_abnormal_copulation1.93418308
28MP0006054_spinal_hemorrhage1.89082415
29MP0001764_abnormal_homeostasis1.86603666
30MP0002876_abnormal_thyroid_physiology1.82477544
31MP0003186_abnormal_redox_activity1.82375665
32MP0003191_abnormal_cellular_cholesterol1.80959273
33MP0000609_abnormal_liver_physiology1.77208113
34MP0005379_endocrine/exocrine_gland_phen1.74447116
35MP0002160_abnormal_reproductive_system1.74125395
36MP0004484_altered_response_of1.74103883
37MP0000015_abnormal_ear_pigmentation1.73011164
38MP0005464_abnormal_platelet_physiology1.67718341
39MP0003656_abnormal_erythrocyte_physiolo1.65849684
40MP0000465_gastrointestinal_hemorrhage1.60093980
41MP0004808_abnormal_hematopoietic_stem1.59813852
42MP0005319_abnormal_enzyme/_coenzyme1.58988256
43MP0010094_abnormal_chromosome_stability1.54523766
44MP0005451_abnormal_body_composition1.51521699
45MP0002163_abnormal_gland_morphology1.50598767
46MP0002102_abnormal_ear_morphology1.49150115
47MP0003950_abnormal_plasma_membrane1.48943829
48MP0000516_abnormal_urinary_system1.48022372
49MP0005367_renal/urinary_system_phenotyp1.48022372
50MP0005174_abnormal_tail_pigmentation1.44542416
51MP0000749_muscle_degeneration1.43716028
52MP0008438_abnormal_cutaneous_collagen1.42771604
53MP0005084_abnormal_gallbladder_morpholo1.38731588
54MP0004134_abnormal_chest_morphology1.37605618
55MP0005253_abnormal_eye_physiology1.36799976
56MP0005584_abnormal_enzyme/coenzyme_acti1.31760934
57MP0000013_abnormal_adipose_tissue1.30167446
58MP0009643_abnormal_urine_homeostasis1.27242342
59MP0009764_decreased_sensitivity_to1.24995400
60MP0005647_abnormal_sex_gland1.20057366
61MP0008775_abnormal_heart_ventricle1.16418390
62MP0005551_abnormal_eye_electrophysiolog1.15055228
63MP0003868_abnormal_feces_composition1.14550909
64MP0010368_abnormal_lymphatic_system1.11220301
65MP0001835_abnormal_antigen_presentation1.09768512
66MP0004215_abnormal_myocardial_fiber1.08631720
67MP0005410_abnormal_fertilization1.05994870
68MP0005389_reproductive_system_phenotype1.05517445
69MP0008007_abnormal_cellular_replicative1.05177192
70MP0002234_abnormal_pharynx_morphology1.04881262
71MP0002282_abnormal_trachea_morphology1.02677833
72MP0009384_cardiac_valve_regurgitation1.02385445
73MP0000383_abnormal_hair_follicle1.01222035
74MP0001661_extended_life_span1.00326761
75MP0004381_abnormal_hair_follicle0.98979628
76MP0000358_abnormal_cell_content/0.98660111
77MP0005503_abnormal_tendon_morphology0.98505765
78MP0010386_abnormal_urinary_bladder0.96635224
79MP0005330_cardiomyopathy0.95872279
80MP0008872_abnormal_physiological_respon0.93322447
81MP0005408_hypopigmentation0.93042944
82MP0005636_abnormal_mineral_homeostasis0.92937179
83MP0002971_abnormal_brown_adipose0.91243437
84MP0009053_abnormal_anal_canal0.91233923
85MP0006036_abnormal_mitochondrial_physio0.90132138
86MP0000598_abnormal_liver_morphology0.89934679
87MP0009250_abnormal_appendicular_skeleto0.89320781
88MP0009763_increased_sensitivity_to0.89142179
89MP0005666_abnormal_adipose_tissue0.88292877
90MP0002928_abnormal_bile_duct0.85510083
91MP0005535_abnormal_body_temperature0.84235678
92MP0004130_abnormal_muscle_cell0.83606759
93MP0003705_abnormal_hypodermis_morpholog0.83001067
94MP0005334_abnormal_fat_pad0.81550184
95MP0002938_white_spotting0.80531496
96MP0001929_abnormal_gametogenesis0.80507170
97MP0009642_abnormal_blood_homeostasis0.80317753
98MP0004084_abnormal_cardiac_muscle0.78685765
99MP0003136_yellow_coat_color0.78581382
100MP0002295_abnormal_pulmonary_circulatio0.78563433
101MP0002128_abnormal_blood_circulation0.77476570
102MP0001756_abnormal_urination0.75438424
103MP0005376_homeostasis/metabolism_phenot0.74793735
104MP0003690_abnormal_glial_cell0.74126657
105MP0003724_increased_susceptibility_to0.72754968
106MP0008469_abnormal_protein_level0.71764342
107MP0005595_abnormal_vascular_smooth0.71292230
108MP0002269_muscular_atrophy0.71153961
109MP0002078_abnormal_glucose_homeostasis0.70861213
110MP0009278_abnormal_bone_marrow0.69872095
111MP0002019_abnormal_tumor_incidence0.69330691
112MP0000613_abnormal_salivary_gland0.69258715
113MP0000689_abnormal_spleen_morphology0.69204648
114MP0003718_maternal_effect0.68286844
115MP0004145_abnormal_muscle_electrophysio0.68093923
116MP0002127_abnormal_cardiovascular_syste0.68047263
117MP0002095_abnormal_skin_pigmentation0.67560098
118MP0009115_abnormal_fat_cell0.66692432
119MP0001270_distended_abdomen0.66317049
120MP0002135_abnormal_kidney_morphology0.65892293
121MP0005623_abnormal_meninges_morphology0.65398872
122MP0002177_abnormal_outer_ear0.64214706
123MP0005395_other_phenotype0.62744735
124MP0002249_abnormal_larynx_morphology0.62234939
125MP0005275_abnormal_skin_tensile0.60464258
126MP0003941_abnormal_skin_development0.58366543
127MP0005448_abnormal_energy_balance0.57988711
128MP0006035_abnormal_mitochondrial_morpho0.57369407
129MP0002136_abnormal_kidney_physiology0.57261929
130MP0002060_abnormal_skin_morphology0.55205441
131MP0006292_abnormal_olfactory_placode0.54824968
132MP0004782_abnormal_surfactant_physiolog0.53635815
133MP0003279_aneurysm0.52967987
134MP0005220_abnormal_exocrine_pancreas0.51598991
135MP0002837_dystrophic_cardiac_calcinosis0.51382555
136MP0004883_abnormal_blood_vessel0.51147061
137MP0000538_abnormal_urinary_bladder0.51094631
138MP0000639_abnormal_adrenal_gland0.50351163
139MP0009765_abnormal_xenobiotic_induced0.50163418
140MP0005248_abnormal_Harderian_gland0.48609806
141MP0001879_abnormal_lymphatic_vessel0.48517577
142MP0000230_abnormal_systemic_arterial0.48478623
143MP0002132_abnormal_respiratory_system0.48273139
144MP0006276_abnormal_autonomic_nervous0.47101248
145MP0005164_abnormal_response_to0.43911786
146MP0001542_abnormal_bone_strength0.43634662
147MP0009379_abnormal_foot_pigmentation0.43490457
148MP0002168_other_aberrant_phenotype0.43153980
149MP0001324_abnormal_eye_pigmentation0.43031208
150MP0004043_abnormal_pH_regulation0.42217295
151MP0002970_abnormal_white_adipose0.41865171
152MP0003953_abnormal_hormone_level0.39907999
153MP0005646_abnormal_pituitary_gland0.39124788
154MP0005266_abnormal_metabolism0.38377350
155MP0004272_abnormal_basement_membrane0.38340613
156MP0001243_abnormal_dermal_layer0.38210034
157MP0004185_abnormal_adipocyte_glucose0.37611524
158MP0006082_CNS_inflammation0.36841858
159MP0000249_abnormal_blood_vessel0.36313581
160MP0002254_reproductive_system_inflammat0.35566727

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.57279863
2Prolonged partial thromboplastin time (HP:0003645)5.79754825
3Deep venous thrombosis (HP:0002625)5.67476082
4Intrahepatic cholestasis (HP:0001406)5.63271416
5Xanthomatosis (HP:0000991)5.28309028
6Hyperglycinuria (HP:0003108)5.25349839
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.17738013
8Hypobetalipoproteinemia (HP:0003563)4.92156039
9Hyperlipoproteinemia (HP:0010980)4.81565042
10Abnormality of serine family amino acid metabolism (HP:0010894)4.71647215
11Abnormality of glycine metabolism (HP:0010895)4.71647215
12Joint hemorrhage (HP:0005261)4.67086795
13Hyperglycinemia (HP:0002154)4.61001939
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.30832351
15Hyperammonemia (HP:0001987)4.27587021
16True hermaphroditism (HP:0010459)4.25631425
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20926380
18Complement deficiency (HP:0004431)4.09502760
19Abnormality of methionine metabolism (HP:0010901)4.07762293
20Ketosis (HP:0001946)4.05987612
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.04425465
22Abnormal protein N-linked glycosylation (HP:0012347)4.04425465
23Abnormal protein glycosylation (HP:0012346)4.04425465
24Abnormal glycosylation (HP:0012345)4.04425465
25Hypoglycemic coma (HP:0001325)3.99951857
26Hypolipoproteinemia (HP:0010981)3.91140087
27Epidermoid cyst (HP:0200040)3.90085393
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.88798713
29Abnormality of pyrimidine metabolism (HP:0004353)3.86032631
30Abnormality of fatty-acid metabolism (HP:0004359)3.82335215
31Pancreatic fibrosis (HP:0100732)3.73752497
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73396635
33Conjugated hyperbilirubinemia (HP:0002908)3.66006623
34Hypoalphalipoproteinemia (HP:0003233)3.65561661
35Pancreatic cysts (HP:0001737)3.61843422
36Abnormality of the common coagulation pathway (HP:0010990)3.52440994
37Renal cortical cysts (HP:0000803)3.50223627
38Hypoproteinemia (HP:0003075)3.47795927
39Abnormality of serum amino acid levels (HP:0003112)3.47666960
40Type I transferrin isoform profile (HP:0003642)3.47485099
41Ketoacidosis (HP:0001993)3.35771896
42Panhypogammaglobulinemia (HP:0003139)3.28875946
43Fat malabsorption (HP:0002630)3.27109868
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22939676
45Abnormality of the intrinsic pathway (HP:0010989)3.20161519
46Generalized aminoaciduria (HP:0002909)3.18333549
47Delayed CNS myelination (HP:0002188)3.12840374
48Proximal tubulopathy (HP:0000114)3.12261131
49Dicarboxylic aciduria (HP:0003215)3.12194194
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.12194194
51Nephronophthisis (HP:0000090)3.10638060
52Lethargy (HP:0001254)3.10202107
53Dynein arm defect of respiratory motile cilia (HP:0012255)3.09832587
54Absent/shortened dynein arms (HP:0200106)3.09832587
55Chronic hepatic failure (HP:0100626)3.06939777
56Enlarged kidneys (HP:0000105)3.06238729
57Vascular calcification (HP:0004934)3.04772472
58Cerebral edema (HP:0002181)3.04022415
59Molar tooth sign on MRI (HP:0002419)2.99988835
60Abnormality of midbrain morphology (HP:0002418)2.99988835
61Abnormality of nucleobase metabolism (HP:0010932)2.99750129
62Hypercholesterolemia (HP:0003124)2.98152065
63Abnormality of complement system (HP:0005339)2.93202909
64Cardiovascular calcification (HP:0011915)2.85230649
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79880451
66Metabolic acidosis (HP:0001942)2.75113842
67Dry hair (HP:0011359)2.71509835
68Bile duct proliferation (HP:0001408)2.68836924
69Abnormal biliary tract physiology (HP:0012439)2.68836924
70Autoimmune hemolytic anemia (HP:0001890)2.66841502
71Hepatocellular carcinoma (HP:0001402)2.66652758
72Type II lissencephaly (HP:0007260)2.64651389
73Systemic lupus erythematosus (HP:0002725)2.62141289
74Medial flaring of the eyebrow (HP:0010747)2.58627049
75Hepatocellular necrosis (HP:0001404)2.58609129
76Steatorrhea (HP:0002570)2.56860411
77Abnormality of purine metabolism (HP:0004352)2.56608878
78Hyperbilirubinemia (HP:0002904)2.56580547
79Hypoglycemic seizures (HP:0002173)2.54691768
80Hydroxyprolinuria (HP:0003080)2.54324617
81Abnormality of proline metabolism (HP:0010907)2.54324617
82Glycosuria (HP:0003076)2.53622474
83Abnormality of urine glucose concentration (HP:0011016)2.53622474
84Abnormal ciliary motility (HP:0012262)2.52955136
85Increased mean platelet volume (HP:0011877)2.48143972
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.47737553
87Hypophosphatemic rickets (HP:0004912)2.47481995
88Abnormality of B cell number (HP:0010975)2.43095068
89Abnormal respiratory epithelium morphology (HP:0012253)2.42533772
90Abnormal respiratory motile cilium morphology (HP:0005938)2.42533772
91Opisthotonus (HP:0002179)2.42522792
92Myocardial infarction (HP:0001658)2.41731131
93Abnormality of the renal medulla (HP:0100957)2.41538641
94Cerebellar dysplasia (HP:0007033)2.38856456
95Vomiting (HP:0002013)2.37621454
96Occipital encephalocele (HP:0002085)2.37186427
97Skin nodule (HP:0200036)2.36681720
98Nausea (HP:0002018)2.35727319
99Congenital hepatic fibrosis (HP:0002612)2.35464801
100Hypoplasia of the uterus (HP:0000013)2.33944931
101Pancreatitis (HP:0001733)2.32159450
102Spontaneous abortion (HP:0005268)2.30516417
103Acute encephalopathy (HP:0006846)2.29024740
104Fair hair (HP:0002286)2.27381373
105Male pseudohermaphroditism (HP:0000037)2.25705872
106Postaxial foot polydactyly (HP:0001830)2.23951262
107Prolonged bleeding time (HP:0003010)2.20318239
108Gout (HP:0001997)2.19595048
109Rickets (HP:0002748)2.19493127
110Hypochromic microcytic anemia (HP:0004840)2.19364553
111Abnormal platelet volume (HP:0011876)2.19307623
1123-Methylglutaconic aciduria (HP:0003535)2.17666807
113Mitochondrial inheritance (HP:0001427)2.17021602
114Cystic liver disease (HP:0006706)2.14981664
115Aplasia/Hypoplasia involving the musculature (HP:0001460)2.13753193
116Abnormality of the prostate (HP:0008775)2.12383258
117Symptomatic seizures (HP:0011145)2.05948951
118Menorrhagia (HP:0000132)2.05747639
119Dyschromatopsia (HP:0007641)2.04639526
120Abnormal respiratory motile cilium physiology (HP:0012261)2.02057196
121Increased intramyocellular lipid droplets (HP:0012240)1.98504446
122Increased serum lactate (HP:0002151)1.97787052
123Abnormality of the renal cortex (HP:0011035)1.93623676
124Alkalosis (HP:0001948)1.93360014
125Median cleft lip (HP:0000161)1.91325657
126Abolished electroretinogram (ERG) (HP:0000550)1.89686835
127Cerebral palsy (HP:0100021)1.89445964
128Abnormality of macular pigmentation (HP:0008002)1.89383849
129Increased CSF lactate (HP:0002490)1.88903681
130Abnormal cartilage morphology (HP:0002763)1.88610421
131Hepatic necrosis (HP:0002605)1.87085086
132Increased purine levels (HP:0004368)1.86880965
133Hyperuricemia (HP:0002149)1.86880965
134Elevated hepatic transaminases (HP:0002910)1.86793486
135Keratoconus (HP:0000563)1.86644925
136Increased corneal curvature (HP:0100692)1.86644925
137Irritability (HP:0000737)1.85920987
138Amyloidosis (HP:0011034)1.83762501
139Respiratory distress (HP:0002098)1.83752705
140Increased muscle lipid content (HP:0009058)1.83060095
141Abnormality of the anterior horn cell (HP:0006802)1.80629782
142Degeneration of anterior horn cells (HP:0002398)1.80629782
143B lymphocytopenia (HP:0010976)1.80247022
144Lactic acidosis (HP:0003128)1.80061125
145Abnormal rod and cone electroretinograms (HP:0008323)1.79072358
146Congenital primary aphakia (HP:0007707)1.78357019
147Glomerulonephritis (HP:0000099)1.78337759
148Hypertriglyceridemia (HP:0002155)1.77988006
149Prostate neoplasm (HP:0100787)1.77954773
150Sclerocornea (HP:0000647)1.77732730
151Brushfield spots (HP:0001088)1.76666173
152Neonatal onset (HP:0003623)1.75216518
153Aortic dissection (HP:0002647)1.74315304
154Malnutrition (HP:0004395)1.73645367
155Epistaxis (HP:0000421)1.73591506
156Hypoplastic pelvis (HP:0008839)1.73566401
157Nephrogenic diabetes insipidus (HP:0009806)1.73006488
158Lipid accumulation in hepatocytes (HP:0006561)1.72950600
159Mitral stenosis (HP:0001718)1.72455967
160Abnormality of vitamin metabolism (HP:0100508)1.72110521
161Mesangial abnormality (HP:0001966)1.71945083
162Attenuation of retinal blood vessels (HP:0007843)1.71943227
163Acute necrotizing encephalopathy (HP:0006965)1.71600298
164Abnormal mitochondria in muscle tissue (HP:0008316)1.71571397
165Elevated erythrocyte sedimentation rate (HP:0003565)1.71370205
166Aplasia/hypoplasia of the uterus (HP:0008684)1.70925934
167Reduced antithrombin III activity (HP:0001976)1.70290301
168Abnormality of renal resorption (HP:0011038)1.68986850
169Renal Fanconi syndrome (HP:0001994)1.68952113
170Recurrent gram-negative bacterial infections (HP:0005420)1.66632087
171Severe visual impairment (HP:0001141)1.65937457
172Methylmalonic acidemia (HP:0002912)1.65739196
173Petechiae (HP:0000967)1.65685106
174Hyperinsulinemic hypoglycemia (HP:0000825)1.64989751
175Pancytopenia (HP:0001876)1.64694934
176Purpura (HP:0000979)1.64132658
177Tachypnea (HP:0002789)1.63703799
178Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63434658
179Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63259009
180CNS demyelination (HP:0007305)1.61826255
181Postaxial hand polydactyly (HP:0001162)1.61202967
182Aortic regurgitation (HP:0001659)1.59275125
183Neonatal respiratory distress (HP:0002643)1.57406876
184Sloping forehead (HP:0000340)1.57313169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.26606899
2INSRR3.45147793
3MUSK3.34429828
4MAP4K23.24788763
5EIF2AK32.79835344
6SIK12.64605478
7STK38L2.59993550
8TAOK32.54835811
9STK162.49409419
10IRAK32.35732484
11ERN12.21613762
12ZAK2.19280271
13FGFR42.17689742
14ERBB41.96773628
15VRK21.95561556
16EPHA31.86505805
17BRSK21.78570400
18NEK91.75631696
19EPHB21.74300401
20LATS11.74027485
21ABL21.72432084
22TEC1.71968697
23CASK1.70643008
24GRK11.63068954
25NME21.55057896
26TIE11.54548971
27JAK31.54133218
28SCYL21.51317779
29BMPR1B1.45886628
30MAP3K141.43948812
31EIF2AK21.39078202
32MST1R1.38824946
33LATS21.38757950
34PIK3CG1.37664218
35AKT31.29624139
36CCNB11.28090430
37KIT1.21782960
38BMPR21.21580582
39WNK31.21339602
40BLK1.20013472
41PIK3CA1.18940507
42PBK1.15448083
43MARK31.14465546
44PIM21.14386950
45VRK11.12842640
46TLK11.11522100
47NUAK11.11003202
48FGFR21.09989893
49IRAK21.09068993
50MAPK111.08785151
51MAP2K31.06947262
52IRAK11.04786628
53PINK11.03776396
54FRK1.03180811
55ITK0.97923267
56PKN10.96197845
57TRPM70.94424474
58WNK40.93212342
59MYLK0.91899451
60PDGFRA0.86688035
61MAP3K60.85989794
62TGFBR20.84761565
63PRKAA20.84418958
64FLT30.84055170
65EIF2AK10.84009389
66MAPKAPK30.83402370
67IKBKB0.83387564
68SGK20.81431883
69IRAK40.78901461
70TNK20.78414131
71MAPK120.76897431
72TBK10.75976492
73PRKCZ0.75244758
74SGK2230.75022036
75SGK4940.75022036
76STK30.73549987
77PLK40.73379876
78CDC70.73115595
79STK390.72242652
80MST40.71586071
81PLK20.70728629
82PLK10.70539014
83MAP3K40.70019922
84MAP2K40.68854450
85PTK2B0.67998106
86YES10.67895455
87TAOK20.67723945
88ATR0.67598554
89CSNK1G20.66560900
90TGFBR10.65056089
91BTK0.64181723
92MAPK130.63593826
93OBSCN0.63212232
94MAPK150.62662895
95MAPK70.62494082
96PRKD20.62304050
97MOS0.62017876
98ERBB30.61156195
99ADRBK10.60986056
100OXSR10.60645870
101IKBKE0.60482579
102CAMK2G0.60264171
103MAP2K70.58693665
104KDR0.58293012
105BUB10.57269974
106DYRK20.56663732
107NME10.56143139
108BRAF0.55641675
109CSNK1G10.55407732
110RPS6KA40.54796877
111MET0.54574990
112WEE10.53812771
113PRKCE0.51803385
114MAPK40.51479483
115MAP2K60.50607311
116MAP4K10.50009784
117ABL10.48582251
118NEK10.48538513
119MAPKAPK50.48471073
120ILK0.48470426
121MAP3K50.47189989
122SRPK10.46605402
123ADRBK20.46111860
124GRK70.46025621
125PRKACG0.45225370
126TAF10.44538484
127IGF1R0.43753789
128ATM0.43491986
129MKNK10.43448515
130ERBB20.43294227
131RAF10.43204293
132RPS6KA50.42992697
133CDK30.42245105
134CAMKK20.41952102
135TYK20.41718515
136BCR0.41099936
137PLK30.40794092
138LCK0.40495139
139GSK3A0.40031279
140PRKACA0.39810130
141PRKCQ0.39473352
142TTK0.39378848
143FGFR10.39184787
144PRKD10.38755089
145CSNK1G30.36845508
146CAMK2A0.34803269
147EPHA20.34648812
148CSNK1A1L0.33578164
149TXK0.33060726
150NEK60.32648355
151CDK90.32628372
152CDK80.32315217
153JAK10.30423153
154PRKAA10.29495211

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.89192963
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10628187
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.84297611
4Fatty acid degradation_Homo sapiens_hsa000712.74829614
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70125553
6Tryptophan metabolism_Homo sapiens_hsa003802.68143177
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61504379
8Propanoate metabolism_Homo sapiens_hsa006402.59266122
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50327631
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45031638
11Complement and coagulation cascades_Homo sapiens_hsa046102.44610074
12Nitrogen metabolism_Homo sapiens_hsa009102.41621263
13Arginine biosynthesis_Homo sapiens_hsa002202.40311081
14Peroxisome_Homo sapiens_hsa041462.38980170
15Proteasome_Homo sapiens_hsa030502.37366319
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35459550
17Fanconi anemia pathway_Homo sapiens_hsa034602.35111288
18Butanoate metabolism_Homo sapiens_hsa006502.27082397
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17929299
20Fatty acid metabolism_Homo sapiens_hsa012122.13407391
21beta-Alanine metabolism_Homo sapiens_hsa004102.08734801
22PPAR signaling pathway_Homo sapiens_hsa033202.07987477
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07156519
24Chemical carcinogenesis_Homo sapiens_hsa052042.02854399
25Steroid hormone biosynthesis_Homo sapiens_hsa001402.01969731
26Non-homologous end-joining_Homo sapiens_hsa034501.97740063
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92116831
28Homologous recombination_Homo sapiens_hsa034401.89659173
29Retinol metabolism_Homo sapiens_hsa008301.89370225
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.88790719
31Histidine metabolism_Homo sapiens_hsa003401.88591215
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86518359
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81106156
34Fatty acid elongation_Homo sapiens_hsa000621.80205172
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.71974915
36RNA polymerase_Homo sapiens_hsa030201.70597564
37RNA degradation_Homo sapiens_hsa030181.68769895
38Base excision repair_Homo sapiens_hsa034101.67379852
39N-Glycan biosynthesis_Homo sapiens_hsa005101.66310256
40Staphylococcus aureus infection_Homo sapiens_hsa051501.62852123
41Phenylalanine metabolism_Homo sapiens_hsa003601.60074560
42Pyruvate metabolism_Homo sapiens_hsa006201.53970984
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53777505
44Tyrosine metabolism_Homo sapiens_hsa003501.48331945
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47768589
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47105287
47Sulfur metabolism_Homo sapiens_hsa009201.46602828
48Caffeine metabolism_Homo sapiens_hsa002321.43625363
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42759356
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.41934953
51Starch and sucrose metabolism_Homo sapiens_hsa005001.36764368
52Folate biosynthesis_Homo sapiens_hsa007901.33391997
53Basal transcription factors_Homo sapiens_hsa030221.31697328
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27316924
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.24519557
56Selenocompound metabolism_Homo sapiens_hsa004501.23396362
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22003379
58Nucleotide excision repair_Homo sapiens_hsa034201.21206941
59Carbon metabolism_Homo sapiens_hsa012001.17143659
60* Arginine and proline metabolism_Homo sapiens_hsa003301.15631962
61Protein export_Homo sapiens_hsa030601.14218638
62Steroid biosynthesis_Homo sapiens_hsa001001.08704561
63Vitamin digestion and absorption_Homo sapiens_hsa049771.08074381
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07770461
65Bile secretion_Homo sapiens_hsa049761.06544408
66ABC transporters_Homo sapiens_hsa020100.98715703
67Glutathione metabolism_Homo sapiens_hsa004800.97209331
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95317329
69Vitamin B6 metabolism_Homo sapiens_hsa007500.95300877
70Biosynthesis of amino acids_Homo sapiens_hsa012300.94802438
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94354568
72One carbon pool by folate_Homo sapiens_hsa006700.94183268
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91469509
74DNA replication_Homo sapiens_hsa030300.90459159
75Olfactory transduction_Homo sapiens_hsa047400.89332143
76Lysine degradation_Homo sapiens_hsa003100.88975234
77Fat digestion and absorption_Homo sapiens_hsa049750.88846602
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.87667836
79Primary immunodeficiency_Homo sapiens_hsa053400.86752942
80Sulfur relay system_Homo sapiens_hsa041220.86456420
81Fatty acid biosynthesis_Homo sapiens_hsa000610.85941478
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81425802
83Graft-versus-host disease_Homo sapiens_hsa053320.80250884
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79443578
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.77981362
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76078491
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69722341
88Glycerolipid metabolism_Homo sapiens_hsa005610.68721284
89RNA transport_Homo sapiens_hsa030130.67786207
90Metabolic pathways_Homo sapiens_hsa011000.65633480
91Hematopoietic cell lineage_Homo sapiens_hsa046400.65209564
92Asthma_Homo sapiens_hsa053100.64104651
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63650815
94Allograft rejection_Homo sapiens_hsa053300.59381596
95ECM-receptor interaction_Homo sapiens_hsa045120.58283169
96Autoimmune thyroid disease_Homo sapiens_hsa053200.53099960
97Platelet activation_Homo sapiens_hsa046110.52878596
98Mismatch repair_Homo sapiens_hsa034300.51522671
99p53 signaling pathway_Homo sapiens_hsa041150.48813609
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48697453
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48360457
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47947561
103Phototransduction_Homo sapiens_hsa047440.46671229
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41495502
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41299915
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41295388
107Pentose phosphate pathway_Homo sapiens_hsa000300.40916620
108Circadian rhythm_Homo sapiens_hsa047100.38485427
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37521230
110Spliceosome_Homo sapiens_hsa030400.37446313
111Arachidonic acid metabolism_Homo sapiens_hsa005900.36634734
112Linoleic acid metabolism_Homo sapiens_hsa005910.36044325
113Oxidative phosphorylation_Homo sapiens_hsa001900.35997709
114Herpes simplex infection_Homo sapiens_hsa051680.31974706
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29540787
116Galactose metabolism_Homo sapiens_hsa000520.23242508
117Parkinsons disease_Homo sapiens_hsa050120.17063334
118Prion diseases_Homo sapiens_hsa050200.14925039
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.14644699
120Pyrimidine metabolism_Homo sapiens_hsa002400.13265091
121Fructose and mannose metabolism_Homo sapiens_hsa000510.11988698
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07935154
123Ovarian steroidogenesis_Homo sapiens_hsa049130.06475878
124Alzheimers disease_Homo sapiens_hsa050100.04665256
125Insulin resistance_Homo sapiens_hsa049310.04612088
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02538392
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.01249976
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.00485193
129Regulation of autophagy_Homo sapiens_hsa04140-0.1686322
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.1651577
131Ether lipid metabolism_Homo sapiens_hsa00565-0.1601769
132Renin-angiotensin system_Homo sapiens_hsa04614-0.1519871
133Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1471091
134Purine metabolism_Homo sapiens_hsa00230-0.1235508
135Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1153518
136AMPK signaling pathway_Homo sapiens_hsa04152-0.1103393
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.1032709
138Protein digestion and absorption_Homo sapiens_hsa04974-0.0988452
139Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0862302
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0814208
141Glucagon signaling pathway_Homo sapiens_hsa04922-0.0688961
142Huntingtons disease_Homo sapiens_hsa05016-0.0176134

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