L3MBTL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.63696443
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.96643673
3synaptic vesicle maturation (GO:0016188)5.95904922
4locomotory exploration behavior (GO:0035641)5.87957349
5vocalization behavior (GO:0071625)5.72263168
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.59749240
7synaptic vesicle exocytosis (GO:0016079)5.58007943
8glutamate secretion (GO:0014047)5.37757118
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.35690364
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27659383
11regulation of synaptic vesicle exocytosis (GO:2000300)5.11423574
12protein localization to synapse (GO:0035418)4.93595467
13regulation of glutamate receptor signaling pathway (GO:1900449)4.91450852
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.90830033
15neuronal action potential propagation (GO:0019227)4.82789389
16neuron cell-cell adhesion (GO:0007158)4.70487166
17exploration behavior (GO:0035640)4.59604248
18dendritic spine morphogenesis (GO:0060997)4.55929277
19neurotransmitter secretion (GO:0007269)4.53390329
20behavioral response to nicotine (GO:0035095)4.52624677
21regulation of synaptic vesicle transport (GO:1902803)4.50342699
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.47340802
23regulation of neuronal synaptic plasticity (GO:0048168)4.46350861
24glutamate receptor signaling pathway (GO:0007215)4.39930502
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.37211626
26synaptic transmission, glutamatergic (GO:0035249)4.35194974
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.20182664
28proline transport (GO:0015824)4.14757717
29gamma-aminobutyric acid transport (GO:0015812)4.11700124
30layer formation in cerebral cortex (GO:0021819)4.08859270
31positive regulation of membrane potential (GO:0045838)4.07470840
32neuron-neuron synaptic transmission (GO:0007270)4.06781662
33neurotransmitter-gated ion channel clustering (GO:0072578)3.95476742
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90165600
35neuron recognition (GO:0008038)3.86849578
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85791662
37long-term memory (GO:0007616)3.85714956
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83856390
39neurotransmitter transport (GO:0006836)3.75653205
40cellular potassium ion homeostasis (GO:0030007)3.75036641
41regulation of synapse structural plasticity (GO:0051823)3.74719300
42regulation of postsynaptic membrane potential (GO:0060078)3.70763922
43postsynaptic membrane organization (GO:0001941)3.62777543
44synaptic vesicle endocytosis (GO:0048488)3.62329489
45cilium or flagellum-dependent cell motility (GO:0001539)3.62170837
46axonal fasciculation (GO:0007413)3.59384395
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.57818060
48transmission of nerve impulse (GO:0019226)3.56779139
49presynaptic membrane assembly (GO:0097105)3.55199501
50regulation of synaptic plasticity (GO:0048167)3.52253884
51cerebellar Purkinje cell differentiation (GO:0021702)3.51721460
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.51387113
53neuromuscular process controlling posture (GO:0050884)3.50407970
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46135534
55membrane depolarization during action potential (GO:0086010)3.45818319
56regulation of dendritic spine morphogenesis (GO:0061001)3.45772927
57detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44208556
58regulation of neurotransmitter levels (GO:0001505)3.43307288
59regulation of neurotransmitter secretion (GO:0046928)3.41885973
60positive regulation of neurotransmitter secretion (GO:0001956)3.40899330
61regulation of vesicle fusion (GO:0031338)3.37869665
62axoneme assembly (GO:0035082)3.37705571
63neuromuscular process controlling balance (GO:0050885)3.35934220
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35675282
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34760670
66epithelial cilium movement (GO:0003351)3.29757037
67pyrimidine nucleobase catabolic process (GO:0006208)3.29717190
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.29351898
69membrane depolarization (GO:0051899)3.29222109
70long-term synaptic potentiation (GO:0060291)3.28974720
71nonmotile primary cilium assembly (GO:0035058)3.28590194
72activation of protein kinase A activity (GO:0034199)3.28552258
73neuronal ion channel clustering (GO:0045161)3.26973090
74vesicle transport along microtubule (GO:0047496)3.26655068
75presynaptic membrane organization (GO:0097090)3.26647382
76dendrite morphogenesis (GO:0048813)3.26483980
77sodium ion export (GO:0071436)3.25952761
78response to auditory stimulus (GO:0010996)3.25590066
79membrane hyperpolarization (GO:0060081)3.25130857
80auditory behavior (GO:0031223)3.22937263
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22800751
82cell migration in hindbrain (GO:0021535)3.21793765
83dendritic spine organization (GO:0097061)3.21018094
84positive regulation of neurotransmitter transport (GO:0051590)3.20107252
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15959019
86positive regulation of synapse maturation (GO:0090129)3.15748001
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15708896
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12552461
89regulation of neurotransmitter transport (GO:0051588)3.11084342
90axon ensheathment in central nervous system (GO:0032291)3.11002249
91central nervous system myelination (GO:0022010)3.11002249
92regulation of calcium ion-dependent exocytosis (GO:0017158)3.10327071
93glycine transport (GO:0015816)3.10249700
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.10117768
95cilium movement (GO:0003341)3.09597293
96synapse assembly (GO:0007416)3.09380817
97mechanosensory behavior (GO:0007638)3.07255664
98negative regulation of translation, ncRNA-mediated (GO:0040033)3.05863191
99regulation of translation, ncRNA-mediated (GO:0045974)3.05863191
100negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.05863191
101learning (GO:0007612)3.04949577
102calcium ion-dependent exocytosis (GO:0017156)3.04041386
103regulation of cilium movement (GO:0003352)3.03116818
104innervation (GO:0060384)3.02692337
105regulation of dendritic spine development (GO:0060998)3.02020266
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00611291
107indolalkylamine metabolic process (GO:0006586)3.00162907
108cell communication by electrical coupling (GO:0010644)2.97918711
109positive regulation of dendritic spine development (GO:0060999)2.97046119
110regulation of synaptic transmission (GO:0050804)2.96427199
111intraspecies interaction between organisms (GO:0051703)2.96391765
112social behavior (GO:0035176)2.96391765
113positive regulation of synaptic transmission (GO:0050806)2.96055021
114prepulse inhibition (GO:0060134)2.95414465
115synapse organization (GO:0050808)2.95126516
116response to histamine (GO:0034776)2.94541158
117synaptic transmission (GO:0007268)2.93524826
118organelle transport along microtubule (GO:0072384)2.93451185
119behavioral response to ethanol (GO:0048149)2.92590571
120photoreceptor cell maintenance (GO:0045494)2.91378491
121cilium assembly (GO:0042384)2.90244809
122cilium organization (GO:0044782)2.90079656
123protein polyglutamylation (GO:0018095)2.87121735
124nephron epithelium morphogenesis (GO:0072088)2.85211052
125nephron tubule morphogenesis (GO:0072078)2.85211052
126nucleobase catabolic process (GO:0046113)2.81454508
127piRNA metabolic process (GO:0034587)2.81014936
128glycerophospholipid catabolic process (GO:0046475)2.75045123
129neuronal action potential (GO:0019228)2.74956782
130detection of light stimulus involved in visual perception (GO:0050908)2.73640580
131detection of light stimulus involved in sensory perception (GO:0050962)2.73640580
132reflex (GO:0060004)2.72194811
133tryptophan catabolic process (GO:0006569)2.70917327
134indole-containing compound catabolic process (GO:0042436)2.70917327
135indolalkylamine catabolic process (GO:0046218)2.70917327
136intraciliary transport (GO:0042073)2.70236633
137neuromuscular synaptic transmission (GO:0007274)2.69577882
138neural tube formation (GO:0001841)2.67443434
139cilium morphogenesis (GO:0060271)2.66352091
140startle response (GO:0001964)2.62890016
141C4-dicarboxylate transport (GO:0015740)2.62820780
142central nervous system projection neuron axonogenesis (GO:0021952)2.62735110
143DNA methylation involved in gamete generation (GO:0043046)2.60395621
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60119180
145protein localization to cilium (GO:0061512)2.59515543
146central nervous system neuron axonogenesis (GO:0021955)2.59112729
147adult walking behavior (GO:0007628)2.58592811
148regulation of microtubule-based movement (GO:0060632)2.56432205
149regulation of respiratory system process (GO:0044065)2.55530499
150L-fucose catabolic process (GO:0042355)2.52837949
151fucose catabolic process (GO:0019317)2.52837949
152L-fucose metabolic process (GO:0042354)2.52837949
153regulation of collateral sprouting (GO:0048670)2.51930678
154inner ear receptor stereocilium organization (GO:0060122)2.51164688
155male meiosis I (GO:0007141)2.49564386
156appendage development (GO:0048736)2.48492437
157limb development (GO:0060173)2.48492437
158spinal cord motor neuron differentiation (GO:0021522)2.47838252
159primary amino compound metabolic process (GO:1901160)2.47690507
160indole-containing compound metabolic process (GO:0042430)2.44587147
161protein K11-linked deubiquitination (GO:0035871)2.44223932
162response to pheromone (GO:0019236)2.43686450
163cell differentiation in spinal cord (GO:0021515)2.42650892
164cAMP catabolic process (GO:0006198)2.40904516
165detection of mechanical stimulus involved in sensory perception (GO:0050974)2.40836430
166regulation of action potential (GO:0098900)2.40814791
167interkinetic nuclear migration (GO:0022027)2.40557165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05164523
2GBX2_23144817_ChIP-Seq_PC3_Human3.83699846
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03988812
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00024586
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89377269
6REST_21632747_ChIP-Seq_MESCs_Mouse2.70851723
7DROSHA_22980978_ChIP-Seq_HELA_Human2.70445141
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55331035
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55331035
10VDR_22108803_ChIP-Seq_LS180_Human2.55258170
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54859993
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49925893
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.48506413
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47921314
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45384819
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44932761
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.42944149
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40447323
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32583780
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31473762
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19125988
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.17675805
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.15445345
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15302863
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.14949925
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14014106
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13748898
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.13396936
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99726794
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92460892
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90971901
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82878684
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.81430529
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79812831
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76956321
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76762642
37TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76762642
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76301484
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76149496
40AR_21572438_ChIP-Seq_LNCaP_Human1.70639812
41SMAD4_21799915_ChIP-Seq_A2780_Human1.69701455
42EWS_26573619_Chip-Seq_HEK293_Human1.63125273
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.56556426
44TAF15_26573619_Chip-Seq_HEK293_Human1.51406227
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.47963515
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.46939505
47ZNF274_21170338_ChIP-Seq_K562_Hela1.44497457
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43167455
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42708617
50BCAT_22108803_ChIP-Seq_LS180_Human1.42305581
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39174994
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35545938
53CBP_20019798_ChIP-Seq_JUKART_Human1.34853810
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34853810
55P300_19829295_ChIP-Seq_ESCs_Human1.33157870
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.32674560
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.32509433
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30153137
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.29582991
60STAT3_23295773_ChIP-Seq_U87_Human1.29524478
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26308776
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.26127957
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.25811787
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24551479
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23650838
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23132617
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22469100
68AR_25329375_ChIP-Seq_VCAP_Human1.22338127
69AR_19668381_ChIP-Seq_PC3_Human1.22006360
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21889673
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21238773
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.19530982
73TP53_22573176_ChIP-Seq_HFKS_Human1.19374615
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19241346
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18909601
76TCF4_23295773_ChIP-Seq_U87_Human1.17644487
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15142404
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14960511
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14885345
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13306302
81TCF4_22108803_ChIP-Seq_LS180_Human1.13112448
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12865370
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12477895
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12367896
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12098458
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10673798
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.09226333
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08817200
89RNF2_27304074_Chip-Seq_NSC_Mouse1.08136302
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.07588819
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06888635
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06817060
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06469248
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.06143788
95TP53_16413492_ChIP-PET_HCT116_Human1.05909310
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04619738
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03152482
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02897846
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02308853
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02307633
101AHR_22903824_ChIP-Seq_MCF-7_Human1.02302247
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.01865969
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01372084
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00597618
105WDR5_24793694_ChIP-Seq_LNCAP_Human1.00446716
106RUNX2_22187159_ChIP-Seq_PCA_Human1.00350898
107IGF1R_20145208_ChIP-Seq_DFB_Human1.00306603
108KDM2B_26808549_Chip-Seq_REH_Human1.00235500
109IRF1_19129219_ChIP-ChIP_H3396_Human1.00223811
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00004019
111KDM2B_26808549_Chip-Seq_K562_Human0.99425585
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99042147
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98712934
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98290958
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.97002208
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96055173
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95757421
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.95175319
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94730396
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.94300653
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.93600423
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93584732
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92354795
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92059243
125NANOG_18555785_Chip-Seq_ESCs_Mouse0.91798895
126FUS_26573619_Chip-Seq_HEK293_Human0.90897572
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90329681
128ER_23166858_ChIP-Seq_MCF-7_Human0.90020969
129NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89815760
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88600788
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88486138
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88486041
133RXR_22108803_ChIP-Seq_LS180_Human0.88148920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58609461
2MP0003880_abnormal_central_pattern5.53917658
3MP0003635_abnormal_synaptic_transmissio4.22676747
4MP0004270_analgesia3.96892205
5MP0009745_abnormal_behavioral_response3.45700331
6MP0001968_abnormal_touch/_nociception3.34290988
7MP0002063_abnormal_learning/memory/cond3.29219917
8MP0005423_abnormal_somatic_nervous3.25766586
9MP0002064_seizures3.19166430
10MP0009046_muscle_twitch3.17356664
11MP0002734_abnormal_mechanical_nocicepti2.81836872
12MP0002572_abnormal_emotion/affect_behav2.80818628
13MP0002272_abnormal_nervous_system2.63498498
14MP0001486_abnormal_startle_reflex2.56737657
15MP0002736_abnormal_nociception_after2.53915749
16MP0002735_abnormal_chemical_nociception2.42618880
17MP0001501_abnormal_sleep_pattern2.38584931
18MP0002822_catalepsy2.37793923
19MP0008877_abnormal_DNA_methylation2.37693788
20MP0006292_abnormal_olfactory_placode2.36949556
21MP0001440_abnormal_grooming_behavior2.18566519
22MP0002653_abnormal_ependyma_morphology2.17884219
23MP0002733_abnormal_thermal_nociception2.13064072
24MP0003136_yellow_coat_color2.03127834
25MP0001970_abnormal_pain_threshold2.03092666
26MP0006276_abnormal_autonomic_nervous2.00073145
27MP0002067_abnormal_sensory_capabilities1.99068672
28MP0002184_abnormal_innervation1.89545361
29MP0000778_abnormal_nervous_system1.88335563
30MP0003787_abnormal_imprinting1.87356668
31MP0004811_abnormal_neuron_physiology1.77961837
32MP0004858_abnormal_nervous_system1.75132965
33MP0002638_abnormal_pupillary_reflex1.73347181
34MP0009780_abnormal_chondrocyte_physiolo1.73078887
35MP0002557_abnormal_social/conspecific_i1.70643980
36MP0003329_amyloid_beta_deposits1.70168140
37MP0003879_abnormal_hair_cell1.66467347
38MP0008569_lethality_at_weaning1.65486061
39MP0000955_abnormal_spinal_cord1.63825007
40MP0001986_abnormal_taste_sensitivity1.62756714
41MP0005645_abnormal_hypothalamus_physiol1.61908402
42MP0004924_abnormal_behavior1.61213290
43MP0005386_behavior/neurological_phenoty1.61213290
44MP0004133_heterotaxia1.60549127
45MP0002102_abnormal_ear_morphology1.52181305
46MP0004142_abnormal_muscle_tone1.49705034
47MP0002066_abnormal_motor_capabilities/c1.44431408
48MP0002882_abnormal_neuron_morphology1.43966506
49MP0001984_abnormal_olfaction1.41158283
50MP0002938_white_spotting1.40702765
51MP0004885_abnormal_endolymph1.37585852
52MP0003646_muscle_fatigue1.37535068
53MP0003122_maternal_imprinting1.35884593
54MP0004147_increased_porphyrin_level1.35355778
55MP0005646_abnormal_pituitary_gland1.33415058
56MP0002909_abnormal_adrenal_gland1.33279068
57MP0003633_abnormal_nervous_system1.32180171
58MP0001502_abnormal_circadian_rhythm1.30460432
59MP0002928_abnormal_bile_duct1.30000842
60MP0001529_abnormal_vocalization1.27262867
61MP0008995_early_reproductive_senescence1.27123693
62MP0003890_abnormal_embryonic-extraembry1.26110944
63MP0003195_calcinosis1.25947296
64MP0005253_abnormal_eye_physiology1.24107369
65MP0003283_abnormal_digestive_organ1.20646703
66MP0006072_abnormal_retinal_apoptosis1.18229006
67MP0003631_nervous_system_phenotype1.12398391
68MP0002152_abnormal_brain_morphology1.10617842
69MP0008872_abnormal_physiological_respon1.03778878
70MP0002229_neurodegeneration1.02369568
71MP0003698_abnormal_male_reproductive1.00601522
72MP0001905_abnormal_dopamine_level0.99760183
73MP0000026_abnormal_inner_ear0.97857489
74MP0005174_abnormal_tail_pigmentation0.97573339
75MP0000751_myopathy0.97425159
76MP0001177_atelectasis0.97349274
77MP0008874_decreased_physiological_sensi0.96555352
78MP0004145_abnormal_muscle_electrophysio0.96212517
79MP0001293_anophthalmia0.95816411
80MP0005195_abnormal_posterior_eye0.91934496
81MP0000566_synostosis0.91899798
82MP0002069_abnormal_eating/drinking_beha0.91298683
83MP0004742_abnormal_vestibular_system0.90728337
84MP0003690_abnormal_glial_cell0.90684363
85MP0002234_abnormal_pharynx_morphology0.90059884
86MP0003938_abnormal_ear_development0.89852507
87MP0000383_abnormal_hair_follicle0.89398417
88MP0000569_abnormal_digit_pigmentation0.88927504
89MP0003119_abnormal_digestive_system0.88154022
90MP0000920_abnormal_myelination0.87657704
91MP0005551_abnormal_eye_electrophysiolog0.87281464
92MP0001188_hyperpigmentation0.87184996
93MP0005377_hearing/vestibular/ear_phenot0.87165227
94MP0003878_abnormal_ear_physiology0.87165227
95MP0000427_abnormal_hair_cycle0.85813195
96MP0008789_abnormal_olfactory_epithelium0.85792748
97MP0004085_abnormal_heartbeat0.83300053
98MP0002876_abnormal_thyroid_physiology0.83229753
99MP0003634_abnormal_glial_cell0.82393193
100MP0008875_abnormal_xenobiotic_pharmacok0.79833897
101MP0001963_abnormal_hearing_physiology0.78776842
102MP0003632_abnormal_nervous_system0.78489400
103MP0004510_myositis0.78315077
104MP0002210_abnormal_sex_determination0.78135371
105MP0002752_abnormal_somatic_nervous0.78100827
106MP0000372_irregular_coat_pigmentation0.77790912
107MP0001485_abnormal_pinna_reflex0.77398323
108MP0001929_abnormal_gametogenesis0.74444754
109MP0000631_abnormal_neuroendocrine_gland0.72673376
110MP0000604_amyloidosis0.71814124
111MP0008961_abnormal_basal_metabolism0.71317037
112MP0005623_abnormal_meninges_morphology0.70336405
113MP0003075_altered_response_to0.67612253
114MP0005535_abnormal_body_temperature0.67349296
115MP0004215_abnormal_myocardial_fiber0.66481355
116MP0003137_abnormal_impulse_conducting0.66422945
117MP0005394_taste/olfaction_phenotype0.66396654
118MP0005499_abnormal_olfactory_system0.66396654
119MP0004484_altered_response_of0.64496043
120MP0005167_abnormal_blood-brain_barrier0.63556336
121MP0010234_abnormal_vibrissa_follicle0.62759012
122MP0003121_genomic_imprinting0.61454426
123MP0005409_darkened_coat_color0.60385005
124MP0001664_abnormal_digestion0.59283727
125MP0010769_abnormal_survival0.58968564
126MP0010770_preweaning_lethality0.58955013
127MP0002082_postnatal_lethality0.58955013
128MP0002837_dystrophic_cardiac_calcinosis0.58447670
129MP0003861_abnormal_nervous_system0.57998378
130MP0001943_abnormal_respiration0.57751271
131MP0004043_abnormal_pH_regulation0.57483297
132MP0010768_mortality/aging0.55526150
133MP0010386_abnormal_urinary_bladder0.53055402
134MP0003123_paternal_imprinting0.51969113
135MP0002090_abnormal_vision0.50534234
136MP0004233_abnormal_muscle_weight0.50136914

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57398606
2Myokymia (HP:0002411)6.75990841
3Focal seizures (HP:0007359)6.15437684
4Visual hallucinations (HP:0002367)5.05290998
5Epileptic encephalopathy (HP:0200134)5.05192765
6Febrile seizures (HP:0002373)4.73700594
7Atonic seizures (HP:0010819)4.40389711
8Progressive cerebellar ataxia (HP:0002073)4.34431677
9Pancreatic cysts (HP:0001737)4.26739989
10Supranuclear gaze palsy (HP:0000605)4.17854926
11Generalized tonic-clonic seizures (HP:0002069)4.01865328
12Absence seizures (HP:0002121)3.95828886
13Pancreatic fibrosis (HP:0100732)3.94799562
14True hermaphroditism (HP:0010459)3.91514471
15Dialeptic seizures (HP:0011146)3.76305034
16Action tremor (HP:0002345)3.70209501
17Ankle clonus (HP:0011448)3.69527797
18Nephronophthisis (HP:0000090)3.52229608
19Urinary bladder sphincter dysfunction (HP:0002839)3.47151185
20Broad-based gait (HP:0002136)3.44826142
21Poor eye contact (HP:0000817)3.44637889
22Molar tooth sign on MRI (HP:0002419)3.43171709
23Abnormality of midbrain morphology (HP:0002418)3.43171709
24Type II lissencephaly (HP:0007260)3.33137122
25Mutism (HP:0002300)3.27385281
26Impaired vibration sensation in the lower limbs (HP:0002166)3.25938663
27Cystic liver disease (HP:0006706)3.21977124
28Medial flaring of the eyebrow (HP:0010747)3.16393183
29Congenital stationary night blindness (HP:0007642)3.15307792
30Abnormality of the lower motor neuron (HP:0002366)3.14801731
31Impaired social interactions (HP:0000735)3.09573866
32Abnormal social behavior (HP:0012433)3.09573866
33Gaze-evoked nystagmus (HP:0000640)3.09529103
34Chronic hepatic failure (HP:0100626)3.06913390
35Abnormality of the renal medulla (HP:0100957)3.06218283
36Dysmetria (HP:0001310)3.05791325
37Hemiparesis (HP:0001269)3.00975752
38Dysdiadochokinesis (HP:0002075)2.94838276
39Spastic gait (HP:0002064)2.93449043
40Depression (HP:0000716)2.93001031
41Congenital primary aphakia (HP:0007707)2.90996479
42Postural instability (HP:0002172)2.89591726
43Abnormal eating behavior (HP:0100738)2.88205261
44Hyperventilation (HP:0002883)2.88022097
45Papilledema (HP:0001085)2.87725225
46Genetic anticipation (HP:0003743)2.87202710
47Anxiety (HP:0000739)2.85889667
48Abnormality of the corticospinal tract (HP:0002492)2.79567149
49Cerebellar dysplasia (HP:0007033)2.79471468
50Truncal ataxia (HP:0002078)2.79261712
51Excessive salivation (HP:0003781)2.78237861
52Drooling (HP:0002307)2.78237861
53Status epilepticus (HP:0002133)2.75475766
54Insomnia (HP:0100785)2.72662421
55Diplopia (HP:0000651)2.71681469
56Abnormality of binocular vision (HP:0011514)2.71681469
57Lower limb amyotrophy (HP:0007210)2.71396219
58Urinary urgency (HP:0000012)2.71317303
59Scanning speech (HP:0002168)2.70934439
60Nephrogenic diabetes insipidus (HP:0009806)2.67793903
61Neurofibrillary tangles (HP:0002185)2.67713932
62Impaired smooth pursuit (HP:0007772)2.67555090
63Amblyopia (HP:0000646)2.66534309
64Cerebral inclusion bodies (HP:0100314)2.65448055
65Termporal pattern (HP:0011008)2.64324317
66Insidious onset (HP:0003587)2.64324317
67Progressive inability to walk (HP:0002505)2.58559902
68Torticollis (HP:0000473)2.55985404
69Hemiplegia (HP:0002301)2.55295383
70Absent speech (HP:0001344)2.49364384
71Genital tract atresia (HP:0001827)2.49341976
72Vaginal atresia (HP:0000148)2.47215612
73Stereotypic behavior (HP:0000733)2.46068256
74Lower limb muscle weakness (HP:0007340)2.43593350
75Lissencephaly (HP:0001339)2.43533012
76Poor coordination (HP:0002370)2.41942779
77Fetal akinesia sequence (HP:0001989)2.38270338
78Amyotrophic lateral sclerosis (HP:0007354)2.37268515
79Abnormal respiratory motile cilium morphology (HP:0005938)2.36728539
80Abnormal respiratory epithelium morphology (HP:0012253)2.36728539
81Epileptiform EEG discharges (HP:0011182)2.33619899
82Bradykinesia (HP:0002067)2.32234280
83Abnormality of ocular smooth pursuit (HP:0000617)2.31589931
84Polydipsia (HP:0001959)2.29354403
85Abnormal drinking behavior (HP:0030082)2.29354403
86Focal dystonia (HP:0004373)2.28714945
87Polyphagia (HP:0002591)2.27547703
88Intention tremor (HP:0002080)2.25006696
89Abnormality of the renal cortex (HP:0011035)2.24735077
90Retinal dysplasia (HP:0007973)2.24061308
91EEG with generalized epileptiform discharges (HP:0011198)2.22325321
92Impaired vibratory sensation (HP:0002495)2.21416934
93Tubular atrophy (HP:0000092)2.20824413
94Ventricular fibrillation (HP:0001663)2.20035860
95Anencephaly (HP:0002323)2.19572871
96Optic nerve hypoplasia (HP:0000609)2.18630903
97Sclerocornea (HP:0000647)2.16831941
98Inability to walk (HP:0002540)2.16395126
99Intestinal atresia (HP:0011100)2.15283365
100Postaxial foot polydactyly (HP:0001830)2.13758907
101Occipital encephalocele (HP:0002085)2.12899541
102Attenuation of retinal blood vessels (HP:0007843)2.12728521
103Elfin facies (HP:0004428)2.11993025
104Abnormal biliary tract physiology (HP:0012439)2.11892136
105Bile duct proliferation (HP:0001408)2.11892136
106Hypsarrhythmia (HP:0002521)2.10762414
107Aplasia/Hypoplasia of the tongue (HP:0010295)2.09827048
108Clumsiness (HP:0002312)2.09812044
109Pointed chin (HP:0000307)2.09795009
110Abnormal ciliary motility (HP:0012262)2.09007640
111Generalized myoclonic seizures (HP:0002123)2.08838552
112Agitation (HP:0000713)2.07154377
113Craniofacial dystonia (HP:0012179)2.06473156
114Congenital hepatic fibrosis (HP:0002612)2.05969138
115Thyroid-stimulating hormone excess (HP:0002925)2.02897617
116Akinesia (HP:0002304)2.02738711
117Limb dystonia (HP:0002451)2.01911805
118Protruding tongue (HP:0010808)2.00513375
119Clonus (HP:0002169)1.96087278
120Dysmetric saccades (HP:0000641)1.94895880
121Postaxial hand polydactyly (HP:0001162)1.94839015
122Abnormality of the labia minora (HP:0012880)1.94577006
123Short foot (HP:0001773)1.93180268
124Tented upper lip vermilion (HP:0010804)1.92897074
125Oligodactyly (hands) (HP:0001180)1.92548627
126Incomplete penetrance (HP:0003829)1.90995865
127Abnormality of salivation (HP:0100755)1.90810886
128Neuronal loss in central nervous system (HP:0002529)1.89630267
129Hyperacusis (HP:0010780)1.89576635
130Overriding aorta (HP:0002623)1.89352911
131Psychosis (HP:0000709)1.88919684
132Megalencephaly (HP:0001355)1.86017556
133Aqueductal stenosis (HP:0002410)1.84432608
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83996096
135Preaxial hand polydactyly (HP:0001177)1.83739866
136Male pseudohermaphroditism (HP:0000037)1.81511080
137Specific learning disability (HP:0001328)1.81023546
138Bony spicule pigmentary retinopathy (HP:0007737)1.80974270
139Pachygyria (HP:0001302)1.80055885
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79955491
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77769186
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.77769186
143Dandy-Walker malformation (HP:0001305)1.75831110
144Narrow forehead (HP:0000341)1.75731278
145Hypoventilation (HP:0002791)1.74913697
146Abnormality of saccadic eye movements (HP:0000570)1.74402581
147Inappropriate behavior (HP:0000719)1.74021628
148Rib fusion (HP:0000902)1.73835931
149Decreased central vision (HP:0007663)1.73712758
150Pheochromocytoma (HP:0002666)1.73693364
151Absent/shortened dynein arms (HP:0200106)1.72773148
152Dynein arm defect of respiratory motile cilia (HP:0012255)1.72773148
153Abnormal EKG (HP:0003115)1.72081876
154Gait imbalance (HP:0002141)1.71587404
155Aplasia of the phalanges of the hand (HP:0009802)1.69343146
156Abnormal respiratory motile cilium physiology (HP:0012261)1.69171510
157Furrowed tongue (HP:0000221)1.68791339
158Dyskinesia (HP:0100660)1.68322279
159Decreased circulating renin level (HP:0003351)1.67470689
160Supernumerary spleens (HP:0009799)1.66420350
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.66315802
162Abolished electroretinogram (ERG) (HP:0000550)1.65936903
163Polyuria (HP:0000103)1.65927948
164Prolonged QT interval (HP:0001657)1.65458901
165Abnormality of DNA repair (HP:0003254)1.63829645
166Morphological abnormality of the pyramidal tract (HP:0002062)1.63205106
167Widely spaced teeth (HP:0000687)1.61624785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.01984255
2NTRK35.01007377
3EPHA43.92268849
4MAP3K93.90984428
5MARK13.26856296
6MAP3K43.20899926
7CASK3.19452176
8TNIK2.86243951
9MAP2K72.72075992
10MINK12.69179584
11INSRR2.67283357
12DAPK22.49388269
13NTRK22.30631276
14BMPR1B2.19709026
15PAK62.12760710
16WNK32.03451924
17MAP2K42.01587910
18MAP3K122.00478503
19NTRK11.96678135
20ADRBK21.94732758
21MAP4K21.78299445
22PINK11.73013890
23KSR21.66597736
24CAMKK11.61566314
25GRK11.60933732
26RIPK41.54163724
27PRKD31.51739016
28CDK51.51276127
29WNK41.50437330
30MAPK131.50424859
31DAPK11.50153200
32PNCK1.44652377
33STK381.41825769
34CDK191.40247576
35SIK21.39238830
36KSR11.33505415
37DYRK21.30215096
38ACVR1B1.29204421
39GRK51.29010363
40PRPF4B1.24637325
41TYRO31.20729459
42PLK21.20224897
43MAPK151.19487127
44TAOK11.19200788
45NUAK11.18396110
46LATS21.16341209
47ZAK1.08417558
48PRKCG1.06616111
49PHKG11.06583951
50PHKG21.06583951
51FES1.04039843
52UHMK11.03990990
53BRD41.03876666
54TAOK31.03446479
55LIMK11.02675934
56CDC42BPA1.02298278
57STK110.99486823
58CAMK10.99327517
59CAMK1D0.97808507
60CAMK2A0.96853669
61CAMKK20.89805383
62OXSR10.86934964
63BCR0.85508249
64MAP3K20.83495324
65NEK20.83014864
66MAP3K130.82818535
67STK38L0.82759482
68PRKCH0.82623153
69AKT30.81553196
70ALK0.81042539
71RET0.80254503
72CSNK1G20.79288153
73ADRBK10.78979163
74CDK180.78738071
75MARK20.78534952
76CDK150.77758473
77TRIM280.74653442
78LMTK20.73636189
79CDK140.73297649
80SGK2230.72416595
81SGK4940.72416595
82CAMK2B0.72092973
83SGK10.71123198
84CDK11A0.67973126
85NME10.67452707
86MKNK20.66762456
87PRKAA10.65657663
88CDK120.65397167
89MAP2K60.64386079
90ERBB20.64126624
91CDK30.63705902
92ARAF0.63514929
93CAMK1G0.63251707
94MARK30.62878935
95PAK30.60867917
96SGK20.56605622
97BRSK20.56129096
98PTK2B0.55982716
99WNK10.55832372
100SGK30.53138112
101DYRK1A0.52805698
102PIK3CA0.51458688
103RPS6KA30.50880201
104FGR0.50477340
105PDK10.50306176
106TLK10.50181979
107DMPK0.49363025
108BMPR20.48496513
109TEC0.47914401
110MAP3K60.47797811
111CAMK2D0.47656669
112TNK20.47406166
113PRKACA0.47378684
114PDPK10.46825030
115TIE10.46131372
116PLK40.46056487
117MAP3K70.45665346
118RAF10.45411585
119FYN0.45109064
120CSNK1G10.45066755
121OBSCN0.44681410
122PRKCE0.44526413
123FGFR20.44482060
124PKN10.44213633
125ROCK20.44135236
126CAMK40.44079000
127STK390.43891968
128MAPK100.42432731
129NEK60.42409538
130MAP3K10.42353409
131CSNK1D0.40945425
132DYRK30.40603456
133TGFBR10.40531159
134PRKACB0.40227081
135CSNK1A10.39627894
136NLK0.39518552
137PRKCZ0.39255094
138PRKG10.39152428
139DYRK1B0.37728028
140SIK30.36329046
141DAPK30.36173012
142PRKCB0.34643979
143CAMK2G0.34643511
144CSNK1E0.34531463
145GRK70.31312177
146FER0.31003981
147RPS6KA20.30476179
148CSNK1A1L0.28989919

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98718024
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47879569
3Olfactory transduction_Homo sapiens_hsa047402.75244104
4GABAergic synapse_Homo sapiens_hsa047272.73203779
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72365031
6Circadian entrainment_Homo sapiens_hsa047132.70121446
7Glutamatergic synapse_Homo sapiens_hsa047242.69541683
8Long-term potentiation_Homo sapiens_hsa047202.56668859
9Morphine addiction_Homo sapiens_hsa050322.52945258
10Amphetamine addiction_Homo sapiens_hsa050312.38932821
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22364986
12Salivary secretion_Homo sapiens_hsa049702.19411710
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13356163
14Dopaminergic synapse_Homo sapiens_hsa047282.11208626
15Linoleic acid metabolism_Homo sapiens_hsa005912.09117352
16Butanoate metabolism_Homo sapiens_hsa006502.02309176
17Insulin secretion_Homo sapiens_hsa049112.00616607
18Cholinergic synapse_Homo sapiens_hsa047251.84955764
19Gastric acid secretion_Homo sapiens_hsa049711.81047153
20Taste transduction_Homo sapiens_hsa047421.80627488
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79790888
22Ether lipid metabolism_Homo sapiens_hsa005651.75166886
23Renin secretion_Homo sapiens_hsa049241.70577722
24Serotonergic synapse_Homo sapiens_hsa047261.69818581
25ABC transporters_Homo sapiens_hsa020101.69066936
26Long-term depression_Homo sapiens_hsa047301.68898862
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66693739
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64167719
29Oxytocin signaling pathway_Homo sapiens_hsa049211.63166670
30Calcium signaling pathway_Homo sapiens_hsa040201.61582968
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60136346
32Cocaine addiction_Homo sapiens_hsa050301.59425116
33Fanconi anemia pathway_Homo sapiens_hsa034601.46659739
34GnRH signaling pathway_Homo sapiens_hsa049121.44676020
35Collecting duct acid secretion_Homo sapiens_hsa049661.43384774
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42969487
37Type II diabetes mellitus_Homo sapiens_hsa049301.38146856
38Axon guidance_Homo sapiens_hsa043601.32658812
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30815243
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.29300243
41Gap junction_Homo sapiens_hsa045401.28719127
42Homologous recombination_Homo sapiens_hsa034401.28650755
43cAMP signaling pathway_Homo sapiens_hsa040241.28643194
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25207856
45Regulation of autophagy_Homo sapiens_hsa041401.23025976
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20620129
47Tryptophan metabolism_Homo sapiens_hsa003801.19070466
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17604049
49Glioma_Homo sapiens_hsa052141.16622161
50Lysine degradation_Homo sapiens_hsa003101.16162249
51Estrogen signaling pathway_Homo sapiens_hsa049151.14146522
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13529187
53ErbB signaling pathway_Homo sapiens_hsa040121.11084257
54Propanoate metabolism_Homo sapiens_hsa006401.09121893
55Basal transcription factors_Homo sapiens_hsa030221.07262730
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06833868
57Melanogenesis_Homo sapiens_hsa049161.04490600
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03090103
59Cardiac muscle contraction_Homo sapiens_hsa042601.01211274
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97271903
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95164081
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.92785798
63Hedgehog signaling pathway_Homo sapiens_hsa043400.91393671
64Phototransduction_Homo sapiens_hsa047440.89472819
65Dorso-ventral axis formation_Homo sapiens_hsa043200.89321435
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.85011923
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84816427
68Vibrio cholerae infection_Homo sapiens_hsa051100.84593003
69Basal cell carcinoma_Homo sapiens_hsa052170.83086215
70Glycerolipid metabolism_Homo sapiens_hsa005610.82442637
71Oocyte meiosis_Homo sapiens_hsa041140.80685370
72Choline metabolism in cancer_Homo sapiens_hsa052310.79491019
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78661138
74Pancreatic secretion_Homo sapiens_hsa049720.78624938
75Nitrogen metabolism_Homo sapiens_hsa009100.76803044
76MAPK signaling pathway_Homo sapiens_hsa040100.75648138
77Dilated cardiomyopathy_Homo sapiens_hsa054140.72938430
78Thyroid hormone synthesis_Homo sapiens_hsa049180.69500588
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68714048
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68435714
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68335857
82Steroid biosynthesis_Homo sapiens_hsa001000.67326023
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65153904
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65078690
85Ras signaling pathway_Homo sapiens_hsa040140.62939280
86Selenocompound metabolism_Homo sapiens_hsa004500.62011657
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61387551
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.61386179
89VEGF signaling pathway_Homo sapiens_hsa043700.59330972
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.58971430
91RNA polymerase_Homo sapiens_hsa030200.58763851
92beta-Alanine metabolism_Homo sapiens_hsa004100.57880998
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57077895
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.56576998
95Inositol phosphate metabolism_Homo sapiens_hsa005620.55794466
96Glucagon signaling pathway_Homo sapiens_hsa049220.55238833
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.54978558
98Histidine metabolism_Homo sapiens_hsa003400.54807405
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54701130
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53503119
101Arachidonic acid metabolism_Homo sapiens_hsa005900.53010363
102Rap1 signaling pathway_Homo sapiens_hsa040150.52093266
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52023885
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51913293
105Circadian rhythm_Homo sapiens_hsa047100.51530151
106RNA degradation_Homo sapiens_hsa030180.51133190
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50140961
108Bile secretion_Homo sapiens_hsa049760.49951008
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49424587
110Alcoholism_Homo sapiens_hsa050340.49019610
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47653337
112Endocytosis_Homo sapiens_hsa041440.46979970
113Type I diabetes mellitus_Homo sapiens_hsa049400.46791591
114Wnt signaling pathway_Homo sapiens_hsa043100.46188162
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43128348
116mTOR signaling pathway_Homo sapiens_hsa041500.43016223
117Huntingtons disease_Homo sapiens_hsa050160.42468084
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42130952
119Oxidative phosphorylation_Homo sapiens_hsa001900.42058393
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41470058
121Chemical carcinogenesis_Homo sapiens_hsa052040.41341983
122Ovarian steroidogenesis_Homo sapiens_hsa049130.41077904
123Prion diseases_Homo sapiens_hsa050200.41029247
124Peroxisome_Homo sapiens_hsa041460.39945909
125Renal cell carcinoma_Homo sapiens_hsa052110.39849603
126Insulin signaling pathway_Homo sapiens_hsa049100.38138836
127Endometrial cancer_Homo sapiens_hsa052130.37868282
128Hippo signaling pathway_Homo sapiens_hsa043900.37686647
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37587910
130Fatty acid metabolism_Homo sapiens_hsa012120.37482799
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36058363
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35413132
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35123852
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34908974
135Non-small cell lung cancer_Homo sapiens_hsa052230.34043771
136Chemokine signaling pathway_Homo sapiens_hsa040620.33653898
137Alzheimers disease_Homo sapiens_hsa050100.32928640
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32436489
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31532552
140African trypanosomiasis_Homo sapiens_hsa051430.30587482
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27345178
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.24167777

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